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Patent code US10150759

Compile Data Set for Download or QSAR
Found 3 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM310221
PNG
(US10150759, Compound 4)
Show SMILES CCC(C)n1cc(C)c2c(cc(cc12)-c1ccc(nc1)N1CCNCC1)C(=O)NCc1c(C)[nH]c(C)cc1=O
Show InChI InChI=1S/C31H38N6O2/c1-6-21(4)37-18-19(2)30-25(31(39)34-17-26-22(5)35-20(3)13-28(26)38)14-24(15-27(30)37)23-7-8-29(33-16-23)36-11-9-32-10-12-36/h7-8,13-16,18,21,32H,6,9-12,17H2,1-5H3,(H,34,39)(H,35,38)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 28n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....


US Patent US10150759 (2018)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM310219
PNG
(US10150759, Compound 1)
Show SMILES CC(C)n1ncc2c(cc(nc12)C1=CC(C)(C)NC(C)(C)C1)C(=O)NCc1c(C)[nH]c(C)cc1=O
Show InChI InChI=1S/C27H36N6O2/c1-15(2)33-24-21(14-29-33)19(25(35)28-13-20-17(4)30-16(3)9-23(20)34)10-22(31-24)18-11-26(5,6)32-27(7,8)12-18/h9-11,14-15,32H,12-13H2,1-8H3,(H,28,35)(H,30,34)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 6.60E+3n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....


US Patent US10150759 (2018)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM310220
PNG
(US10150759, Compound 2)
Show SMILES CC(C)n1ncc2c(cc(nc12)C1CC(C)(C)NC(C)(C)C1)C(=O)NCc1c(C)[nH]c(C)cc1=O
Show InChI InChI=1S/C27H38N6O2/c1-15(2)33-24-21(14-29-33)19(25(35)28-13-20-17(4)30-16(3)9-23(20)34)10-22(31-24)18-11-26(5,6)32-27(7,8)12-18/h9-10,14-15,18,32H,11-13H2,1-8H3,(H,28,35)(H,30,34)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 7.10E+3n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....


US Patent US10150759 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%