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Patent code US10150760

Compile Data Set for Download or QSAR

Found 390 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Apelin receptor


(Homo sapiens)
BDBM310228
PNG
(US10150760, Example 15.0 | US10150760, Example 16....)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cn2)nnc1C1CCOCC1
Show InChI InChI=1S/C22H27FN6O5S/c1-14(11-19-24-12-16(23)13-25-19)35(30,31)28-22-27-26-21(15-7-9-34-10-8-15)29(22)20-17(32-2)5-4-6-18(20)33-3/h4-6,12-15H,7-11H2,1-3H3,(H,27,28)/t14-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US10150760 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM310277
PNG
(US10150760, Example 73.0 | US10150760, Example 74....)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2OCC[C@H]2C)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C23H29ClN6O6S/c1-13-9-10-36-19(13)22-27-28-23(30(22)18-16(33-3)7-6-8-17(18)34-4)29-37(31,32)14(2)20(35-5)21-25-11-15(24)12-26-21/h6-8,11-14,19-20H,9-10H2,1-5H3,(H,28,29)/t13-,14+,19+,20+/m1/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US10150760 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM310279
PNG
(US10150760, Example 75.0 | US10150760, Example 76....)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(Cl)cn2)nnc1[C@H]1OCC[C@H]1C
Show InChI InChI=1S/C23H29ClN6O5S/c1-13-9-10-35-20(13)22-27-28-23(30(22)19-17(33-4)7-6-8-18(19)34-5)29-36(31,32)15(3)14(2)21-25-11-16(24)12-26-21/h6-8,11-15,20H,9-10H2,1-5H3,(H,28,29)/t13-,14+,15+,20+/m1/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US10150760 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM310299
PNG
(US10150760, Example 95.0 | US10150760, Example 96....)
Show SMILES COc1ncnc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@@H](OC(C)C)c2ncc(C)cn2)nnc1[C@H]1CCCO1
Show InChI InChI=1S/C23H32N8O6S/c1-13(2)37-18(19-24-10-14(3)11-25-19)15(4)38(32,33)30-23-29-28-20(16-8-7-9-36-16)31(23)17-21(34-5)26-12-27-22(17)35-6/h10-13,15-16,18H,7-9H2,1-6H3,(H,29,30)/t15-,16+,18+/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US10150760 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM310305
PNG
(US10150760, Example 101.0 | US10150760, Example 10...)
Show SMILES COc1ncnc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(Cl)cn2)nnc1[C@H]1CCCOC1
Show InChI InChI=1S/C21H27ClN8O5S/c1-12(17-23-8-15(22)9-24-17)13(2)36(31,32)29-21-28-27-18(14-6-5-7-35-10-14)30(21)16-19(33-3)25-11-26-20(16)34-4/h8-9,11-14H,5-7,10H2,1-4H3,(H,28,29)/t12-,13-,14-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US10150760 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM310310
PNG
(US10150760, Example 106.0 | US10150760, Example 10...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2cnc(C)cn2)nnc1[C@H]1CCCCO1
Show InChI InChI=1S/C24H32N6O5S/c1-15-13-26-18(14-25-15)16(2)17(3)36(31,32)29-24-28-27-23(21-9-6-7-12-35-21)30(24)22-19(33-4)10-8-11-20(22)34-5/h8,10-11,13-14,16-17,21H,6-7,9,12H2,1-5H3,(H,28,29)/t16-,17-,21+/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US10150760 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM310312
PNG
(Preparation of (1R,2S)-1-(5-chloropyrimidin-2-yl)-...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2CCC(C)(C)O2)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C24H31ClN6O6S/c1-14(20(36-6)21-26-12-15(25)13-27-21)38(32,33)30-23-29-28-22(18-10-11-24(2,3)37-18)31(23)19-16(34-4)8-7-9-17(19)35-5/h7-9,12-14,18,20H,10-11H2,1-6H3,(H,29,30)/t14-,18+,20-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US10150760 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM310325
PNG
(US10150760, Example 121.0 | US10150760, Example 12...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(C)cn2)nnc1[C@@H]1CCO[C@@H]1C
Show InChI InChI=1S/C24H32N6O5S/c1-14-12-25-22(26-13-14)15(2)17(4)36(31,32)29-24-28-27-23(18-10-11-35-16(18)3)30(24)21-19(33-5)8-7-9-20(21)34-6/h7-9,12-13,15-18H,10-11H2,1-6H3,(H,28,29)/t15-,16+,17-,18+/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US10150760 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM310325
PNG
(US10150760, Example 121.0 | US10150760, Example 12...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(C)cn2)nnc1[C@@H]1CCO[C@@H]1C
Show InChI InChI=1S/C24H32N6O5S/c1-14-12-25-22(26-13-14)15(2)17(4)36(31,32)29-24-28-27-23(18-10-11-35-16(18)3)30(24)21-19(33-5)8-7-9-20(21)34-6/h7-9,12-13,15-18H,10-11H2,1-6H3,(H,28,29)/t15-,16+,17-,18+/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US10150760 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM310338
PNG
(US10150760, Example 134.0 | US10150760, Example 13...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2cnc(C)cn2)nnc1[C@H]1CCCOC1
Show InChI InChI=1S/C24H32N6O5S/c1-15-12-26-19(13-25-15)16(2)17(3)36(31,32)29-24-28-27-23(18-8-7-11-35-14-18)30(24)22-20(33-4)9-6-10-21(22)34-5/h6,9-10,12-13,16-18H,7-8,11,14H2,1-5H3,(H,28,29)/t16-,17-,18-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US10150760 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM310340
PNG
(US10150760, Example 136.0 | US10150760, Example 13...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@@H](OC(C)C)c2ncc(C)cn2)nnc1[C@H]1CCCOC1
Show InChI InChI=1S/C26H36N6O6S/c1-16(2)38-23(24-27-13-17(3)14-28-24)18(4)39(33,34)31-26-30-29-25(19-9-8-12-37-15-19)32(26)22-20(35-5)10-7-11-21(22)36-6/h7,10-11,13-14,16,18-19,23H,8-9,12,15H2,1-6H3,(H,30,31)/t18-,19-,23+/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US10150760 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM310342
PNG
(US10150760, Example 138.0 | US10150760, Example 13...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2CCC(C)(C)O2)n1-c1c(OC)ncnc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C22H29ClN8O6S/c1-12(16(34-4)17-24-9-13(23)10-25-17)38(32,33)30-21-29-28-18(14-7-8-22(2,3)37-14)31(21)15-19(35-5)26-11-27-20(15)36-6/h9-12,14,16H,7-8H2,1-6H3,(H,29,30)/t12-,14+,16-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US10150760 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM310353
PNG
(US10150760, Example 173.0 | US10150760, Example 17...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(cn2)C#N)nnc1[C@H]1CCOC1
Show InChI InChI=1S/C23H27N7O5S/c1-14(21-25-11-16(10-24)12-26-21)15(2)36(31,32)29-23-28-27-22(17-8-9-35-13-17)30(23)20-18(33-3)6-5-7-19(20)34-4/h5-7,11-12,14-15,17H,8-9,13H2,1-4H3,(H,28,29)/t14-,15-,17-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US10150760 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM310364
PNG
(US10150760, Example 184.0)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(C)cn2)nnc1[C@H]1CCS(=O)(=O)C1
Show InChI InChI=1S/C23H30N6O6S2/c1-14-11-24-21(25-12-14)15(2)16(3)37(32,33)28-23-27-26-22(17-9-10-36(30,31)13-17)29(23)20-18(34-4)7-6-8-19(20)35-5/h6-8,11-12,15-17H,9-10,13H2,1-5H3,(H,27,28)/t15-,16-,17-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US10150760 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM310373
PNG
(US10150760, Example 193.0 | US10150760, Example 19...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](O)c2ncc(C)cn2)nnc1[C@@H]1CCCCO1
Show InChI InChI=1S/C23H30N6O6S/c1-14-12-24-21(25-13-14)20(30)15(2)36(31,32)28-23-27-26-22(18-8-5-6-11-35-18)29(23)19-16(33-3)9-7-10-17(19)34-4/h7,9-10,12-13,15,18,20,30H,5-6,8,11H2,1-4H3,(H,27,28)/t15-,18-,20-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US10150760 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM310381
PNG
(US10150760, Example 201.0 | US10150760, Example 20...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@@H]2COCCO2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C23H30N6O7S/c1-14-11-24-21(25-12-14)20(34-5)15(2)37(30,31)28-23-27-26-22(18-13-35-9-10-36-18)29(23)19-16(32-3)7-6-8-17(19)33-4/h6-8,11-12,15,18,20H,9-10,13H2,1-5H3,(H,27,28)/t15-,18-,20-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US10150760 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM310389
PNG
(US10150760, Example 209.0 | US10150760, Example 21...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@@H](OC(C)C)c2ncc(C)cn2)nnc1[C@H]1CCC(C)(C)O1
Show InChI InChI=1S/C27H38N6O6S/c1-16(2)38-23(24-28-14-17(3)15-29-24)18(4)40(34,35)32-26-31-30-25(21-12-13-27(5,6)39-21)33(26)22-19(36-7)10-9-11-20(22)37-8/h9-11,14-16,18,21,23H,12-13H2,1-8H3,(H,31,32)/t18-,21+,23+/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US10150760 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM310391
PNG
(US10150760, Example 211.0 | US10150760, Example 21...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@@H](OC(C)C)c2cnc(C)cn2)nnc1[C@H]1CCCCO1
Show InChI InChI=1S/C26H36N6O6S/c1-16(2)38-24(19-15-27-17(3)14-28-19)18(4)39(33,34)31-26-30-29-25(22-10-7-8-13-37-22)32(26)23-20(35-5)11-9-12-21(23)36-6/h9,11-12,14-16,18,22,24H,7-8,10,13H2,1-6H3,(H,30,31)/t18-,22+,24+/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US10150760 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM310403
PNG
(US10150760, Example 223.0 | US10150760, Example 22...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(C)cn2)nnc1[C@H]1CCCS1
Show InChI InChI=1S/C23H30N6O4S2/c1-14-12-24-21(25-13-14)15(2)16(3)35(30,31)28-23-27-26-22(19-10-7-11-34-19)29(23)20-17(32-4)8-6-9-18(20)33-5/h6,8-9,12-13,15-16,19H,7,10-11H2,1-5H3,(H,27,28)/t15-,16-,19+/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US10150760 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM310424
PNG
(US10150760, Example 247.0 | US10150760, Example 24...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@@H]2COCCO2)n1C1CCOCC1)c1ncc(Cl)cn1
Show InChI InChI=1S/C19H27ClN6O6S/c1-12(16(29-2)17-21-9-13(20)10-22-17)33(27,28)25-19-24-23-18(15-11-31-7-8-32-15)26(19)14-3-5-30-6-4-14/h9-10,12,14-16H,3-8,11H2,1-2H3,(H,24,25)/t12-,15-,16-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US10150760 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM310437
PNG
(US10150760, Example 260.0 | US10150760, Example 26...)
Show SMILES CC(C)O[C@H]([C@H](C)S(=O)(=O)Nc1nnc([C@@H]2CCCO2)n1C1CCOCC1)c1cnc(C)cn1
Show InChI InChI=1S/C22H34N6O5S/c1-14(2)33-20(18-13-23-15(3)12-24-18)16(4)34(29,30)27-22-26-25-21(19-6-5-9-32-19)28(22)17-7-10-31-11-8-17/h12-14,16-17,19-20H,5-11H2,1-4H3,(H,26,27)/t16-,19-,20+/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US10150760 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM310437
PNG
(US10150760, Example 260.0 | US10150760, Example 26...)
Show SMILES CC(C)O[C@H]([C@H](C)S(=O)(=O)Nc1nnc([C@@H]2CCCO2)n1C1CCOCC1)c1cnc(C)cn1
Show InChI InChI=1S/C22H34N6O5S/c1-14(2)33-20(18-13-23-15(3)12-24-18)16(4)34(29,30)27-22-26-25-21(19-6-5-9-32-19)28(22)17-7-10-31-11-8-17/h12-14,16-17,19-20H,5-11H2,1-4H3,(H,26,27)/t16-,19-,20+/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US10150760 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM310448
PNG
(US10150760, Example 271.0 | US10150760, Example 27...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@@H]2COCCO2)n1C1(C)CC1)c1ncc(Cl)cn1
Show InChI InChI=1S/C18H25ClN6O5S/c1-11(14(28-3)15-20-8-12(19)9-21-15)31(26,27)24-17-23-22-16(13-10-29-6-7-30-13)25(17)18(2)4-5-18/h8-9,11,13-14H,4-7,10H2,1-3H3,(H,23,24)/t11-,13-,14-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US10150760 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM310466
PNG
(US10150760, Example 289.0 | US10150760, Example 29...)
Show SMILES COCC1(CC1)n1c(NS(=O)(=O)[C@@H](C)[C@H](OC)c2ncc(Cl)cn2)nnc1[C@H]1CCC(C)(C)O1
Show InChI InChI=1S/C21H31ClN6O5S/c1-13(16(32-5)17-23-10-14(22)11-24-17)34(29,30)27-19-26-25-18(15-6-7-20(2,3)33-15)28(19)21(8-9-21)12-31-4/h10-11,13,15-16H,6-9,12H2,1-5H3,(H,26,27)/t13-,15+,16-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US10150760 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM310470
PNG
(US10150760, Example 293.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@@H]2CN(C)C(=O)C2)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C23H28ClN7O6S/c1-13(20(37-5)21-25-10-15(24)11-26-21)38(33,34)29-23-28-27-22(14-9-18(32)30(2)12-14)31(23)19-16(35-3)7-6-8-17(19)36-4/h6-8,10-11,13-14,20H,9,12H2,1-5H3,(H,28,29)/t13-,14-,20-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US10150760 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM310478
PNG
(US10150760, Example 301.0 | US10150760, Example 30...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2COCCO2)n1C(C)C)c1ncc(Cl)cn1
Show InChI InChI=1S/C17H25ClN6O5S/c1-10(2)24-16(13-9-28-5-6-29-13)21-22-17(24)23-30(25,26)11(3)14(27-4)15-19-7-12(18)8-20-15/h7-8,10-11,13-14H,5-6,9H2,1-4H3,(H,22,23)/t11-,13+,14-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US10150760 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM310478
PNG
(US10150760, Example 301.0 | US10150760, Example 30...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2COCCO2)n1C(C)C)c1ncc(Cl)cn1
Show InChI InChI=1S/C17H25ClN6O5S/c1-10(2)24-16(13-9-28-5-6-29-13)21-22-17(24)23-30(25,26)11(3)14(27-4)15-19-7-12(18)8-20-15/h7-8,10-11,13-14H,5-6,9H2,1-4H3,(H,22,23)/t11-,13+,14-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US10150760 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM310481
PNG
(US10150760, Example 304.0 | US10150760, Example 34...)
Show SMILES COCC1(CC1)n1c(NS(=O)(=O)[C@@H](C)[C@H](OC)c2ncc(Cl)cn2)nnc1[C@H]1COCCO1
Show InChI InChI=1S/C19H27ClN6O6S/c1-12(15(30-3)16-21-8-13(20)9-22-16)33(27,28)25-18-24-23-17(14-10-31-6-7-32-14)26(18)19(4-5-19)11-29-2/h8-9,12,14-15H,4-7,10-11H2,1-3H3,(H,24,25)/t12-,14+,15-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US10150760 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM310526
PNG
(US10150760, Example 352.0)
Show SMILES CC(C)O[C@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2CC[C@@H](C)O2)n1C1CC1)c1ncc(Cl)cn1
Show InChI InChI=1S/C20H29ClN6O4S/c1-11(2)30-17(18-22-9-14(21)10-23-18)13(4)32(28,29)26-20-25-24-19(27(20)15-6-7-15)16-8-5-12(3)31-16/h9-13,15-17H,5-8H2,1-4H3,(H,25,26)/t12-,13+,16-,17-/m1/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US10150760 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM310534
PNG
(US10150760, Example 360.0 | US10150760, Example 36...)
Show SMILES COCC(COC)n1c(NS(=O)(=O)[C@@H](C)[C@@H](OC(C)C)c2ncc(F)cn2)nnc1[C@H]1CC[C@@H](C)O1
Show InChI InChI=1S/C22H35FN6O6S/c1-13(2)34-19(20-24-9-16(23)10-25-20)15(4)36(30,31)28-22-27-26-21(18-8-7-14(3)35-18)29(22)17(11-32-5)12-33-6/h9-10,13-15,17-19H,7-8,11-12H2,1-6H3,(H,27,28)/t14-,15+,18-,19-/m1/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US10150760 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM310544
PNG
(US10150760, Example 370.0 | US10150760, Example 37...)
Show SMILES COCC(COC)n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(OC)cn2)nnc1[C@H]1CC[C@@H](C)O1
Show InChI InChI=1S/C21H34N6O6S/c1-13-7-8-18(33-13)20-24-25-21(27(20)16(11-30-4)12-31-5)26-34(28,29)15(3)14(2)19-22-9-17(32-6)10-23-19/h9-10,13-16,18H,7-8,11-12H2,1-6H3,(H,25,26)/t13-,14+,15+,18-/m1/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US10150760 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM310554
PNG
(US10150760, Example 380.0 | US10150760, Example 38...)
Show SMILES COCC(COC)n1c(NS(=O)(=O)[C@@H](C)[C@H](OC)c2ccc(Cl)cn2)nnc1[C@H]1CC[C@@H](C)O1
Show InChI InChI=1S/C21H32ClN5O6S/c1-13-6-9-18(33-13)20-24-25-21(27(20)16(11-30-3)12-31-4)26-34(28,29)14(2)19(32-5)17-8-7-15(22)10-23-17/h7-8,10,13-14,16,18-19H,6,9,11-12H2,1-5H3,(H,25,26)/t13-,14+,18-,19+/m1/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US10150760 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM310567
PNG
(US10150760, Example 395.0 | US10150760, Example 39...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(F)cn2)nnc1[C@@H]1COC(C)(C)C1
Show InChI InChI=1S/C24H31FN6O5S/c1-14(21-26-11-17(25)12-27-21)15(2)37(32,33)30-23-29-28-22(16-10-24(3,4)36-13-16)31(23)20-18(34-5)8-7-9-19(20)35-6/h7-9,11-12,14-16H,10,13H2,1-6H3,(H,29,30)/t14-,15-,16-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US10150760 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM310573
PNG
(US10150760, Example 401.0 | US10150760, Example 40...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2CCOC2)n1Cc1ccon1)c1ncc(Cl)cn1
Show InChI InChI=1S/C18H22ClN7O5S/c1-11(15(29-2)16-20-7-13(19)8-21-16)32(27,28)25-18-23-22-17(12-3-5-30-10-12)26(18)9-14-4-6-31-24-14/h4,6-8,11-12,15H,3,5,9-10H2,1-2H3,(H,23,25)/t11-,12-,15-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US10150760 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM310577
PNG
(US10150760, Example 405.0 | US10150760, Example 40...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(C2CCC(=O)N2C)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C23H28ClN7O6S/c1-13(20(37-5)21-25-11-14(24)12-26-21)38(33,34)29-23-28-27-22(15-9-10-18(32)30(15)2)31(23)19-16(35-3)7-6-8-17(19)36-4/h6-8,11-13,15,20H,9-10H2,1-5H3,(H,28,29)/t13-,15?,20-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US10150760 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM310589
PNG
(US10150760, Example 417.0 | US10150760, Example 41...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@@H](OC(C)C)c2ncc(C)cn2)nnc1C1CCC(=O)N1C
Show InChI InChI=1S/C26H35N7O6S/c1-15(2)39-23(24-27-13-16(3)14-28-24)17(4)40(35,36)31-26-30-29-25(18-11-12-21(34)32(18)5)33(26)22-19(37-6)9-8-10-20(22)38-7/h8-10,13-15,17-18,23H,11-12H2,1-7H3,(H,30,31)/t17-,18?,23+/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US10150760 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM310602
PNG
(US10150760, Example 436.0)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)c2ccccc2)nnc1[C@H]1CCCO1
Show InChI InChI=1S/C22H26N4O5S/c1-15(16-9-5-4-6-10-16)32(27,28)25-22-24-23-21(19-13-8-14-31-19)26(22)20-17(29-2)11-7-12-18(20)30-3/h4-7,9-12,15,19H,8,13-14H2,1-3H3,(H,24,25)/t15-,19-/m1/s1
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n/an/an/an/a 2.65E+3n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US10150760 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM310607
PNG
(US10150760, Example 441.0 | US10150760, Example 44...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(Cl)cn2)nnc1[C@@H]1CO[C@@H](C)C1
Show InChI InChI=1S/C23H29ClN6O5S/c1-13-9-16(12-35-13)22-27-28-23(30(22)20-18(33-4)7-6-8-19(20)34-5)29-36(31,32)15(3)14(2)21-25-10-17(24)11-26-21/h6-8,10-11,13-16H,9,12H2,1-5H3,(H,28,29)/t13-,14-,15-,16-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US10150760 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM310228
PNG
(US10150760, Example 15.0 | US10150760, Example 16....)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cn2)nnc1C1CCOCC1
Show InChI InChI=1S/C22H27FN6O5S/c1-14(11-19-24-12-16(23)13-25-19)35(30,31)28-22-27-26-21(15-7-9-34-10-8-15)29(22)20-17(32-2)5-4-6-18(20)33-3/h4-6,12-15H,7-11H2,1-3H3,(H,27,28)/t14-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US10150760 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM310237
PNG
(Preparation of (2S,3R)-3-(5-cyano-2-pyrimidinyl)-N...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(Cl)cn2)nnc1[C@@H]1CCCO1
Show InChI InChI=1S/C22H27ClN6O5S/c1-13(20-24-11-15(23)12-25-20)14(2)35(30,31)28-22-27-26-21(18-9-6-10-34-18)29(22)19-16(32-3)7-5-8-17(19)33-4/h5,7-8,11-14,18H,6,9-10H2,1-4H3,(H,27,28)/t13-,14-,18-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US10150760 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM310242
PNG
(US10150760, Example 37.0)
Show SMILES COc1ncnc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ccc(Cl)cn2)nnc1[C@@H]1CCOC1
Show InChI InChI=1S/C21H26ClN7O5S/c1-12(16-6-5-15(22)9-23-16)13(2)35(30,31)28-21-27-26-18(14-7-8-34-10-14)29(21)17-19(32-3)24-11-25-20(17)33-4/h5-6,9,11-14H,7-8,10H2,1-4H3,(H,27,28)/t12-,13-,14+/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US10150760 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM310246
PNG
(US10150760, Example 41.0)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(Cl)cn2)nnc1[C@@H]1CCN(C1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C27H36ClN7O6S/c1-16(23-29-13-19(28)14-30-23)17(2)42(37,38)33-25-32-31-24(18-11-12-34(15-18)26(36)41-27(3,4)5)35(25)22-20(39-6)9-8-10-21(22)40-7/h8-10,13-14,16-18H,11-12,15H2,1-7H3,(H,32,33)/t16-,17-,18+/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US10150760 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM310255
PNG
(US10150760, Example 51.0 | US10150760, Example 52....)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2CCCO2)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C22H27ClN6O6S/c1-13(19(34-4)20-24-11-14(23)12-25-20)36(30,31)28-22-27-26-21(17-9-6-10-35-17)29(22)18-15(32-2)7-5-8-16(18)33-3/h5,7-8,11-13,17,19H,6,9-10H2,1-4H3,(H,27,28)/t13-,17+,19-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US10150760 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM310268
PNG
(US10150760, Example 64.0 | US10150760, Example 65....)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2CCCOC2)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C23H29ClN6O6S/c1-14(20(35-4)21-25-11-16(24)12-26-21)37(31,32)29-23-28-27-22(15-7-6-10-36-13-15)30(23)19-17(33-2)8-5-9-18(19)34-3/h5,8-9,11-12,14-15,20H,6-7,10,13H2,1-4H3,(H,28,29)/t14-,15-,20-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US10150760 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM310270
PNG
(US10150760, Example 66.0 | US10150760, Example 67....)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@@H](OC(C)C)c2cnc(C)cn2)nnc1[C@H]1CCCO1
Show InChI InChI=1S/C25H34N6O6S/c1-15(2)37-23(18-14-26-16(3)13-27-18)17(4)38(32,33)30-25-29-28-24(21-11-8-12-36-21)31(25)22-19(34-5)9-7-10-20(22)35-6/h7,9-10,13-15,17,21,23H,8,11-12H2,1-6H3,(H,29,30)/t17-,21+,23+/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US10150760 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM310277
PNG
(US10150760, Example 73.0 | US10150760, Example 74....)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2OCC[C@H]2C)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C23H29ClN6O6S/c1-13-9-10-36-19(13)22-27-28-23(30(22)18-16(33-3)7-6-8-17(18)34-4)29-37(31,32)14(2)20(35-5)21-25-11-15(24)12-26-21/h6-8,11-14,19-20H,9-10H2,1-5H3,(H,28,29)/t13-,14+,19+,20+/m1/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US10150760 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM310281
PNG
(US10150760, Example 77.0 | US10150760, Example 78....)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2CC[C@@H](C)O2)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C23H29ClN6O6S/c1-13-9-10-18(36-13)22-27-28-23(30(22)19-16(33-3)7-6-8-17(19)34-4)29-37(31,32)14(2)20(35-5)21-25-11-15(24)12-26-21/h6-8,11-14,18,20H,9-10H2,1-5H3,(H,28,29)/t13-,14+,18-,20+/m1/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US10150760 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM310301
PNG
(US10150760, Example 97.0 | US10150760, Example 98....)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@@H](OC(C)C)c2ncc(C)cn2)nnc1[C@H]1CCCO1
Show InChI InChI=1S/C25H34N6O6S/c1-15(2)37-22(23-26-13-16(3)14-27-23)17(4)38(32,33)30-25-29-28-24(20-11-8-12-36-20)31(25)21-18(34-5)9-7-10-19(21)35-6/h7,9-10,13-15,17,20,22H,8,11-12H2,1-6H3,(H,29,30)/t17-,20+,22+/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US10150760 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM310316
PNG
(US10150760, Example 112.0 | US10150760, Example 11...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2CCCCO2)n1C1(C)CC1)c1ncc(Cl)cn1
Show InChI InChI=1S/C19H27ClN6O4S/c1-12(15(29-3)16-21-10-13(20)11-22-16)31(27,28)25-18-24-23-17(14-6-4-5-9-30-14)26(18)19(2)7-8-19/h10-12,14-15H,4-9H2,1-3H3,(H,24,25)/t12-,14+,15-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US10150760 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM310328
PNG
(US10150760, Example 124.0 | US10150760, Example 12...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2CCOC2)n1C1(C)CC1)c1ncc(Cl)cn1
Show InChI InChI=1S/C18H25ClN6O4S/c1-11(14(28-3)15-20-8-13(19)9-21-15)30(26,27)24-17-23-22-16(12-4-7-29-10-12)25(17)18(2)5-6-18/h8-9,11-12,14H,4-7,10H2,1-3H3,(H,23,24)/t11-,12-,14-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US10150760 (2018)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%