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Patent code US10150763

Compile Data Set for Download or QSAR
Found 76 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histone deacetylase 6


(Homo sapiens (human))
BDBM310701
PNG
(US10150763, Example A)
Show SMILES Cc1nsc(n1)N(CCCCCCC(=O)NO)c1ccccn1
Show InChI InChI=1S/C15H21N5O2S/c1-12-17-15(23-19-12)20(13-8-5-6-10-16-13)11-7-3-2-4-9-14(21)18-22/h5-6,8,10,22H,2-4,7,9,11H2,1H3,(H,18,21)
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n/an/a 1.76n/an/an/an/an/an/a



Karus Therapeutics Limited

US Patent


Assay Description
The assay is described in WO2008/062201.


US Patent US10150763 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM310701
PNG
(US10150763, Example A)
Show SMILES Cc1nsc(n1)N(CCCCCCC(=O)NO)c1ccccn1
Show InChI InChI=1S/C15H21N5O2S/c1-12-17-15(23-19-12)20(13-8-5-6-10-16-13)11-7-3-2-4-9-14(21)18-22/h5-6,8,10,22H,2-4,7,9,11H2,1H3,(H,18,21)
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n/an/a 226n/an/an/an/an/an/a



Karus Therapeutics Limited

US Patent


Assay Description
The assay is described in WO2008/062201.


US Patent US10150763 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM310707
PNG
(N-Hydroxy-7-(pyridin-2-yl(1,3,4-thiadiazol-2-yl)am...)
Show SMILES ONC(=O)CCCCCCN(c1nncs1)c1ccccn1
Show InChI InChI=1S/C14H19N5O2S/c20-13(18-21)8-3-1-2-6-10-19(14-17-16-11-22-14)12-7-4-5-9-15-12/h4-5,7,9,11,21H,1-3,6,8,10H2,(H,18,20)
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Karus Therapeutics Limited

US Patent


Assay Description
The assay is described in WO2008/062201.


US Patent US10150763 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (human))
BDBM310725
PNG
(7-((4-(4-Fluorophenyl)pyridin-2-yl)(1-methyl-1H-py...)
Show SMILES Cn1ccc(n1)N(CCCCCCC(=O)NO)c1cc(ccn1)-c1ccc(F)cc1
Show InChI InChI=1S/C22H26FN5O2/c1-27-15-12-20(25-27)28(14-5-3-2-4-6-22(29)26-30)21-16-18(11-13-24-21)17-7-9-19(23)10-8-17/h7-13,15-16,30H,2-6,14H2,1H3,(H,26,29)
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Karus Therapeutics Limited

US Patent


Assay Description
The assay is described in WO2008/062201.


US Patent US10150763 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (human))
BDBM310728
PNG
(8-((5-Fluoropyridin-2-yl)(3-(trifluoromethyl)1,2,4...)
Show SMILES ONC(=O)CCCCCCCN(c1nc(ns1)C(F)(F)F)c1ccccn1
Show InChI InChI=1S/C16H20F3N5O2S/c17-16(18,19)14-21-15(27-23-14)24(12-8-5-6-10-20-12)11-7-3-1-2-4-9-13(25)22-26/h5-6,8,10,26H,1-4,7,9,11H2,(H,22,25)
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Karus Therapeutics Limited

US Patent


Assay Description
The assay is described in WO2008/062201.


US Patent US10150763 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM310702
PNG
(N-Hydroxy-7-[(3-methyl-1,2,4-thiadiazol-5-yl)(pyri...)
Show SMILES Cc1nsc(n1)N(CCCCCCC(=O)NO)c1cccnc1
Show InChI InChI=1S/C15H21N5O2S/c1-12-17-15(23-19-12)20(13-7-6-9-16-11-13)10-5-3-2-4-8-14(21)18-22/h6-7,9,11,22H,2-5,8,10H2,1H3,(H,18,21)
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Karus Therapeutics Limited

US Patent


Assay Description
The assay is described in WO2008/062201.


US Patent US10150763 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (human))
BDBM310703
PNG
(N-Hydroxy-7-((3-methyl-1,2,4-oxadiazol-5-yl)(pyrid...)
Show SMILES Cc1noc(n1)N(CCCCCCC(=O)NO)c1ccccn1
Show InChI InChI=1S/C15H21N5O3/c1-12-17-15(23-19-12)20(13-8-5-6-10-16-13)11-7-3-2-4-9-14(21)18-22/h5-6,8,10,22H,2-4,7,9,11H2,1H3,(H,18,21)
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Karus Therapeutics Limited

US Patent


Assay Description
The assay is described in WO2008/062201.


US Patent US10150763 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (human))
BDBM310705
PNG
(N-Hydroxy-7-((1-methyl-1H-pyrazol-3-yl)(pyridin-2-...)
Show SMILES Cn1ccc(n1)N(CCCCCCC(=O)NO)c1ccccn1
Show InChI InChI=1S/C16H23N5O2/c1-20-13-10-15(18-20)21(14-8-5-6-11-17-14)12-7-3-2-4-9-16(22)19-23/h5-6,8,10-11,13,23H,2-4,7,9,12H2,1H3,(H,19,22)
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Karus Therapeutics Limited

US Patent


Assay Description
The assay is described in WO2008/062201.


US Patent US10150763 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (human))
BDBM310710
PNG
(N-Hydroxy-8-((5-methyl-1,3,4-thiadiazol-2-yl)(pyri...)
Show SMILES Cc1nnc(s1)N(CCCCCCCC(=O)NO)c1ccccn1
Show InChI InChI=1S/C16H23N5O2S/c1-13-18-19-16(24-13)21(14-9-6-7-11-17-14)12-8-4-2-3-5-10-15(22)20-23/h6-7,9,11,23H,2-5,8,10,12H2,1H3,(H,20,22)
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Karus Therapeutics Limited

US Patent


Assay Description
The assay is described in WO2008/062201.


US Patent US10150763 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (human))
BDBM310723
PNG
(7-(Benzo[d]oxazol-2-yl(5-fluoropyridin-2-yl)amino)...)
Show SMILES ONC(=O)CCCCCCN(c1nc2ccccc2o1)c1ccc(F)cn1
Show InChI InChI=1S/C19H21FN4O3/c20-14-10-11-17(21-13-14)24(12-6-2-1-3-9-18(25)23-26)19-22-15-7-4-5-8-16(15)27-19/h4-5,7-8,10-11,13,26H,1-3,6,9,12H2,(H,23,25)
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Karus Therapeutics Limited

US Patent


Assay Description
The assay is described in WO2008/062201.


US Patent US10150763 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM310725
PNG
(7-((4-(4-Fluorophenyl)pyridin-2-yl)(1-methyl-1H-py...)
Show SMILES Cn1ccc(n1)N(CCCCCCC(=O)NO)c1cc(ccn1)-c1ccc(F)cc1
Show InChI InChI=1S/C22H26FN5O2/c1-27-15-12-20(25-27)28(14-5-3-2-4-6-22(29)26-30)21-16-18(11-13-24-21)17-7-9-19(23)10-8-17/h7-13,15-16,30H,2-6,14H2,1H3,(H,26,29)
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Karus Therapeutics Limited

US Patent


Assay Description
The assay is described in WO2008/062201.


US Patent US10150763 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (human))
BDBM310732
PNG
(8-((4-(4-Fluorophenyl)-pyridin-2-yl)(3-methyl-1,2,...)
Show SMILES Cc1nsc(n1)N(CCCCCCCC(=O)NO)c1cc(ccn1)-c1ccc(F)cc1
Show InChI InChI=1S/C22H26FN5O2S/c1-16-25-22(31-27-16)28(14-6-4-2-3-5-7-21(29)26-30)20-15-18(12-13-24-20)17-8-10-19(23)11-9-17/h8-13,15,30H,2-7,14H2,1H3,(H,26,29)
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Karus Therapeutics Limited

US Patent


Assay Description
The assay is described in WO2008/062201.


US Patent US10150763 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (human))
BDBM310733
PNG
(7-((5-Fluoropyridin-2-yl)(3-(trifluoromethyl)1,2,4...)
Show SMILES ONC(=O)CCCCCCN(c1nc(ns1)C(F)(F)F)c1ccc(F)cn1
Show InChI InChI=1S/C15H17F4N5O2S/c16-10-6-7-11(20-9-10)24(8-4-2-1-3-5-12(25)22-26)14-21-13(23-27-14)15(17,18)19/h6-7,9,26H,1-5,8H2,(H,22,25)
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Karus Therapeutics Limited

US Patent


Assay Description
The assay is described in WO2008/062201.


US Patent US10150763 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (human))
BDBM310737
PNG
(N-Hydroxy-7-(pyridin-2-yl(thiazol-2-yl)amino)hepta...)
Show SMILES ONC(=O)CCCCCCN(c1nccs1)c1ccccn1
Show InChI InChI=1S/C15H20N4O2S/c20-14(18-21)8-3-1-2-6-11-19(15-17-10-12-22-15)13-7-4-5-9-16-13/h4-5,7,9-10,12,21H,1-3,6,8,11H2,(H,18,20)
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Karus Therapeutics Limited

US Patent


Assay Description
The assay is described in WO2008/062201.


US Patent US10150763 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (human))
BDBM310708
PNG
(N-Hydroxy-8-(pyridin-2-yl(1,3,4-thiadiazol-2-yl)am...)
Show SMILES ONC(=O)CCCCCCCN(c1nncs1)c1ccccn1
Show InChI InChI=1S/C15H21N5O2S/c21-14(19-22)9-4-2-1-3-7-11-20(15-18-17-12-23-15)13-8-5-6-10-16-13/h5-6,8,10,12,22H,1-4,7,9,11H2,(H,19,21)
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Karus Therapeutics Limited

US Patent


Assay Description
The assay is described in WO2008/062201.


US Patent US10150763 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (human))
BDBM310709
PNG
(N-Hydroxy-7-((5-methyl-1,3,4-thiadiazol-2-yl)(pyri...)
Show SMILES Cc1nnc(s1)N(CCCCCCC(=O)NO)c1ccccn1
Show InChI InChI=1S/C15H21N5O2S/c1-12-17-18-15(23-12)20(13-8-5-6-10-16-13)11-7-3-2-4-9-14(21)19-22/h5-6,8,10,22H,2-4,7,9,11H2,1H3,(H,19,21)
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Karus Therapeutics Limited

US Patent


Assay Description
The assay is described in WO2008/062201.


US Patent US10150763 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM310711
PNG
(7-(Benzo[d]oxazol-2-yl(pyridin-2-yl)amino)-N-hydro...)
Show SMILES ONC(=O)CCCCCCN(c1nc2ccccc2o1)c1ccccn1
Show InChI InChI=1S/C19H22N4O3/c24-18(22-25)12-3-1-2-8-14-23(17-11-6-7-13-20-17)19-21-15-9-4-5-10-16(15)26-19/h4-7,9-11,13,25H,1-3,8,12,14H2,(H,22,24)
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Karus Therapeutics Limited

US Patent


Assay Description
The assay is described in WO2008/062201.


US Patent US10150763 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (human))
BDBM310714
PNG
(N-Hydroxy-8-((1-methyl-1H-benzo[d]imidazol-2-yl)(p...)
Show SMILES Cn1c(nc2ccccc12)N(CCCCCCCC(=O)NO)c1ccccn1
Show InChI InChI=1S/C21H27N5O2/c1-25-18-12-7-6-11-17(18)23-21(25)26(19-13-8-9-15-22-19)16-10-4-2-3-5-14-20(27)24-28/h6-9,11-13,15,28H,2-5,10,14,16H2,1H3,(H,24,27)
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Karus Therapeutics Limited

US Patent


Assay Description
The assay is described in WO2008/062201.


US Patent US10150763 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (human))
BDBM310715
PNG
(N-Hydroxy-7-(pyridin-2-yl(1,2,4-thiadiazol-5-yl)am...)
Show SMILES ONC(=O)CCCCCCN(c1ncns1)c1ccccn1
Show InChI InChI=1S/C14H19N5O2S/c20-13(18-21)8-3-1-2-6-10-19(14-16-11-17-22-14)12-7-4-5-9-15-12/h4-5,7,9,11,21H,1-3,6,8,10H2,(H,18,20)
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Karus Therapeutics Limited

US Patent


Assay Description
The assay is described in WO2008/062201.


US Patent US10150763 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (human))
BDBM310719
PNG
(7-((5-Fluoropyridin-2-yl)(1-methyl-1H-benzo[d]imid...)
Show SMILES Cn1c(nc2ccccc12)N(CCCCCCC(=O)NO)c1ccc(F)cn1
Show InChI InChI=1S/C20H24FN5O2/c1-25-17-9-6-5-8-16(17)23-20(25)26(18-12-11-15(21)14-22-18)13-7-3-2-4-10-19(27)24-28/h5-6,8-9,11-12,14,28H,2-4,7,10,13H2,1H3,(H,24,27)
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Karus Therapeutics Limited

US Patent


Assay Description
The assay is described in WO2008/062201.


US Patent US10150763 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (human))
BDBM310720
PNG
(8-((5-Fluoropyridin-2-yl)(1-methyl-1H-benzo[d]imid...)
Show SMILES Cn1c(nc2ccccc12)N(CCCCCCC(=O)C(=O)NO)c1ccc(F)cn1
Show InChI InChI=1S/C21H24FN5O3/c1-26-17-9-6-5-8-16(17)24-21(26)27(19-12-11-15(22)14-23-19)13-7-3-2-4-10-18(28)20(29)25-30/h5-6,8-9,11-12,14,30H,2-4,7,10,13H2,1H3,(H,25,29)
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Karus Therapeutics Limited

US Patent


Assay Description
The assay is described in WO2008/062201.


US Patent US10150763 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (human))
BDBM310731
PNG
(7-((4-(4-Fluorophenyl)pyridin-2-yl)(3-methyl-1,2,4...)
Show SMILES Cc1nsc(n1)N(CCCCCCC(=O)NO)c1cc(ccn1)-c1ccc(F)cc1
Show InChI InChI=1S/C21H24FN5O2S/c1-15-24-21(30-26-15)27(13-5-3-2-4-6-20(28)25-29)19-14-17(11-12-23-19)16-7-9-18(22)10-8-16/h7-12,14,29H,2-6,13H2,1H3,(H,25,28)
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n/an/a<500n/an/an/an/an/an/a



Karus Therapeutics Limited

US Patent


Assay Description
The assay is described in WO2008/062201.


US Patent US10150763 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (human))
BDBM310735
PNG
(7-(Benzo[d]thiazol-2-yl(pyridin-2-yl)amino)-N-hydr...)
Show SMILES ONC(=O)CCCCCCN(c1nc2ccccc2s1)c1ccccn1
Show InChI InChI=1S/C19H22N4O2S/c24-18(22-25)12-3-1-2-8-14-23(17-11-6-7-13-20-17)19-21-15-9-4-5-10-16(15)26-19/h4-7,9-11,13,25H,1-3,8,12,14H2,(H,22,24)
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Karus Therapeutics Limited

US Patent


Assay Description
The assay is described in WO2008/062201.


US Patent US10150763 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM310705
PNG
(N-Hydroxy-7-((1-methyl-1H-pyrazol-3-yl)(pyridin-2-...)
Show SMILES Cn1ccc(n1)N(CCCCCCC(=O)NO)c1ccccn1
Show InChI InChI=1S/C16H23N5O2/c1-20-13-10-15(18-20)21(14-8-5-6-11-17-14)12-7-3-2-4-9-16(22)19-23/h5-6,8,10-11,13,23H,2-4,7,9,12H2,1H3,(H,19,22)
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Karus Therapeutics Limited

US Patent


Assay Description
The assay is described in WO2008/062201.


US Patent US10150763 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (human))
BDBM310706
PNG
(N-Hydroxy-8-((1-methyl-1H-pyrazol-3-yl)(pyridin-2-...)
Show SMILES Cn1ccc(n1)N(CCCCCCCC(=O)NO)c1ccccn1
Show InChI InChI=1S/C17H25N5O2/c1-21-14-11-16(19-21)22(15-9-6-7-12-18-15)13-8-4-2-3-5-10-17(23)20-24/h6-7,9,11-12,14,24H,2-5,8,10,13H2,1H3,(H,20,23)
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Karus Therapeutics Limited

US Patent


Assay Description
The assay is described in WO2008/062201.


US Patent US10150763 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (human))
BDBM310707
PNG
(N-Hydroxy-7-(pyridin-2-yl(1,3,4-thiadiazol-2-yl)am...)
Show SMILES ONC(=O)CCCCCCN(c1nncs1)c1ccccn1
Show InChI InChI=1S/C14H19N5O2S/c20-13(18-21)8-3-1-2-6-10-19(14-17-16-11-22-14)12-7-4-5-9-15-12/h4-5,7,9,11,21H,1-3,6,8,10H2,(H,18,20)
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Karus Therapeutics Limited

US Patent


Assay Description
The assay is described in WO2008/062201.


US Patent US10150763 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (human))
BDBM310717
PNG
(7-((5-Fluoropyridin-2-yl)(3-methyl-1,2,4-oxadiazol...)
Show SMILES Cc1noc(n1)N(CCCCCCC(=O)NO)c1ccc(F)cn1
Show InChI InChI=1S/C15H20FN5O3/c1-11-18-15(24-20-11)21(13-8-7-12(16)10-17-13)9-5-3-2-4-6-14(22)19-23/h7-8,10,23H,2-6,9H2,1H3,(H,19,22)
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Karus Therapeutics Limited

US Patent


Assay Description
The assay is described in WO2008/062201.


US Patent US10150763 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (human))
BDBM310724
PNG
(8-(Benzo[d]oxazol-2-yl(5-fluoropyridin-2-yl)amino)...)
Show SMILES ONC(=O)CCCCCCCN(c1nc2ccccc2o1)c1ccc(F)cn1
Show InChI InChI=1S/C20H23FN4O3/c21-15-11-12-18(22-14-15)25(13-7-3-1-2-4-10-19(26)24-27)20-23-16-8-5-6-9-17(16)28-20/h5-6,8-9,11-12,14,27H,1-4,7,10,13H2,(H,24,26)
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Karus Therapeutics Limited

US Patent


Assay Description
The assay is described in WO2008/062201.


US Patent US10150763 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (human))
BDBM310727
PNG
(7-((5-Fluoropyridin-2-yl)(3-(trifluoromethyl)1,2,4...)
Show SMILES ONC(=O)CCCCCCN(c1nc(ns1)C(F)(F)F)c1ccccn1
Show InChI InChI=1S/C15H18F3N5O2S/c16-15(17,18)13-20-14(26-22-13)23(11-7-4-5-9-19-11)10-6-2-1-3-8-12(24)21-25/h4-5,7,9,25H,1-3,6,8,10H2,(H,21,24)
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Karus Therapeutics Limited

US Patent


Assay Description
The assay is described in WO2008/062201.


US Patent US10150763 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (human))
BDBM310711
PNG
(7-(Benzo[d]oxazol-2-yl(pyridin-2-yl)amino)-N-hydro...)
Show SMILES ONC(=O)CCCCCCN(c1nc2ccccc2o1)c1ccccn1
Show InChI InChI=1S/C19H22N4O3/c24-18(22-25)12-3-1-2-8-14-23(17-11-6-7-13-20-17)19-21-15-9-4-5-10-16(15)26-19/h4-7,9-11,13,25H,1-3,8,12,14H2,(H,22,24)
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Karus Therapeutics Limited

US Patent


Assay Description
The assay is described in WO2008/062201.


US Patent US10150763 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (human))
BDBM310721
PNG
(7-((5-Fluoropyridin-2-yl)(1-methyl-1H-pyrazol-3-yl...)
Show SMILES Cn1ccc(n1)N(CCCCCCC(=O)NO)c1ccc(F)cn1
Show InChI InChI=1S/C16H22FN5O2/c1-21-11-9-15(19-21)22(14-8-7-13(17)12-18-14)10-5-3-2-4-6-16(23)20-24/h7-9,11-12,24H,2-6,10H2,1H3,(H,20,23)
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Karus Therapeutics Limited

US Patent


Assay Description
The assay is described in WO2008/062201.


US Patent US10150763 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (human))
BDBM310722
PNG
(8-((5-Fluoropyridin-2-yl)(1-methyl-1H-pyrazol-3-yl...)
Show SMILES Cn1ccc(n1)N(CCCCCCCC(=O)NO)c1ccc(F)cn1
Show InChI InChI=1S/C17H24FN5O2/c1-22-12-10-16(20-22)23(15-9-8-14(18)13-19-15)11-6-4-2-3-5-7-17(24)21-25/h8-10,12-13,25H,2-7,11H2,1H3,(H,21,24)
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Karus Therapeutics Limited

US Patent


Assay Description
The assay is described in WO2008/062201.


US Patent US10150763 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (human))
BDBM310702
PNG
(N-Hydroxy-7-[(3-methyl-1,2,4-thiadiazol-5-yl)(pyri...)
Show SMILES Cc1nsc(n1)N(CCCCCCC(=O)NO)c1cccnc1
Show InChI InChI=1S/C15H21N5O2S/c1-12-17-15(23-19-12)20(13-7-6-9-16-11-13)10-5-3-2-4-8-14(21)18-22/h6-7,9,11,22H,2-5,8,10H2,1H3,(H,18,21)
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Karus Therapeutics Limited

US Patent


Assay Description
The assay is described in WO2008/062201.


US Patent US10150763 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (human))
BDBM310704
PNG
(N-Hydroxy-8-((3-methyl-1,2,4-oxadiazol-5-yl)(pyrid...)
Show SMILES Cc1noc(n1)N(CCCCCCCC(=O)NO)c1ccccn1
Show InChI InChI=1S/C16H23N5O3/c1-13-18-16(24-20-13)21(14-9-6-7-11-17-14)12-8-4-2-3-5-10-15(22)19-23/h6-7,9,11,23H,2-5,8,10,12H2,1H3,(H,19,22)
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Karus Therapeutics Limited

US Patent


Assay Description
The assay is described in WO2008/062201.


US Patent US10150763 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (human))
BDBM310716
PNG
(N-Hydroxy-8-(pyridin-2-yl(1,2,4-thiadiazol-5-yl)am...)
Show SMILES ONC(=O)CCCCCCCN(c1ncns1)c1ccccn1
Show InChI InChI=1S/C15H21N5O2S/c21-14(19-22)9-4-2-1-3-7-11-20(15-17-12-18-23-15)13-8-5-6-10-16-13/h5-6,8,10,12,22H,1-4,7,9,11H2,(H,19,21)
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Karus Therapeutics Limited

US Patent


Assay Description
The assay is described in WO2008/062201.


US Patent US10150763 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM310703
PNG
(N-Hydroxy-7-((3-methyl-1,2,4-oxadiazol-5-yl)(pyrid...)
Show SMILES Cc1noc(n1)N(CCCCCCC(=O)NO)c1ccccn1
Show InChI InChI=1S/C15H21N5O3/c1-12-17-15(23-19-12)20(13-8-5-6-10-16-13)11-7-3-2-4-9-14(21)18-22/h5-6,8,10,22H,2-4,7,9,11H2,1H3,(H,18,21)
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Karus Therapeutics Limited

US Patent


Assay Description
The assay is described in WO2008/062201.


US Patent US10150763 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (human))
BDBM310713
PNG
(N-Hydroxy-7-((1-methyl-1H-benzo[d]imidazol-2-yl)(p...)
Show SMILES Cn1c(nc2ccccc12)N(CCCCCCC(=O)NO)c1ccccn1
Show InChI InChI=1S/C20H25N5O2/c1-24-17-11-6-5-10-16(17)22-20(24)25(18-12-7-8-14-21-18)15-9-3-2-4-13-19(26)23-27/h5-8,10-12,14,27H,2-4,9,13,15H2,1H3,(H,23,26)
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Karus Therapeutics Limited

US Patent


Assay Description
The assay is described in WO2008/062201.


US Patent US10150763 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (human))
BDBM310729
PNG
(7-((5-Fluoropyridin-2-yl)(3-methyl-1,2,4-thiadiazo...)
Show SMILES Cc1nsc(n1)N(CCCCCCC(=O)NO)c1ccc(F)cn1
Show InChI InChI=1S/C15H20FN5O2S/c1-11-18-15(24-20-11)21(13-8-7-12(16)10-17-13)9-5-3-2-4-6-14(22)19-23/h7-8,10,23H,2-6,9H2,1H3,(H,19,22)
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Karus Therapeutics Limited

US Patent


Assay Description
The assay is described in WO2008/062201.


US Patent US10150763 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (human))
BDBM310730
PNG
(8-((5-Fluoropyridin-2-yl)(3-methyl-1,2,4-thiadiazo...)
Show SMILES Cc1nsc(n1)N(CCCCCCCC(=O)NO)c1ccc(F)cn1
Show InChI InChI=1S/C16H22FN5O2S/c1-12-19-16(25-21-12)22(14-9-8-13(17)11-18-14)10-6-4-2-3-5-7-15(23)20-24/h8-9,11,24H,2-7,10H2,1H3,(H,20,23)
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Karus Therapeutics Limited

US Patent


Assay Description
The assay is described in WO2008/062201.


US Patent US10150763 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (human))
BDBM310736
PNG
(8-(Benzo[d]thiazol-2-yl(pyridin-2-yl)amino)-N-hydr...)
Show SMILES ONC(=O)CCCCCCCN(c1nc2ccccc2s1)c1ccccn1
Show InChI InChI=1S/C20H24N4O2S/c25-19(23-26)13-4-2-1-3-9-15-24(18-12-7-8-14-21-18)20-22-16-10-5-6-11-17(16)27-20/h5-8,10-12,14,26H,1-4,9,13,15H2,(H,23,25)
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Karus Therapeutics Limited

US Patent


Assay Description
The assay is described in WO2008/062201.


US Patent US10150763 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (human))
BDBM310738
PNG
(US10150763, Example LL)
Show SMILES ONC(=O)CCCCCCCN(c1nccs1)c1ccccn1
Show InChI InChI=1S/C16H22N4O2S/c21-15(19-22)9-4-2-1-3-7-12-20(16-18-11-13-23-16)14-8-5-6-10-17-14/h5-6,8,10-11,13,22H,1-4,7,9,12H2,(H,19,21)
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Karus Therapeutics Limited

US Patent


Assay Description
The assay is described in WO2008/062201.


US Patent US10150763 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (human))
BDBM310712
PNG
(8-(Benzo[d]oxazol-2-yl(pyridin-2-yl)amino)-N-hydro...)
Show SMILES ONC(=O)CCCCCCCN(c1nc2ccccc2o1)c1ccccn1
Show InChI InChI=1S/C20H24N4O3/c25-19(23-26)13-4-2-1-3-9-15-24(18-12-7-8-14-21-18)20-22-16-10-5-6-11-17(16)27-20/h5-8,10-12,14,26H,1-4,9,13,15H2,(H,23,25)
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Karus Therapeutics Limited

US Patent


Assay Description
The assay is described in WO2008/062201.


US Patent US10150763 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (human))
BDBM310718
PNG
(8-((5-Fluoropyridin-2-yl)(3-methyl-1,2,4-oxadiazol...)
Show SMILES Cc1noc(n1)N(CCCCCCCC(=O)NO)c1ccc(F)cn1
Show InChI InChI=1S/C16H22FN5O3/c1-12-19-16(25-21-12)22(14-9-8-13(17)11-18-14)10-6-4-2-3-5-7-15(23)20-24/h8-9,11,24H,2-7,10H2,1H3,(H,20,23)
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Karus Therapeutics Limited

US Patent


Assay Description
The assay is described in WO2008/062201.


US Patent US10150763 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (human))
BDBM310726
PNG
(8-((4-(4-Fluorophenyl)pyridin-2-yl)(1-methyl-1H-py...)
Show SMILES Cn1ccc(n1)N(CCCCCCCC(=O)NO)c1cc(ccn1)-c1ccc(F)cc1
Show InChI InChI=1S/C23H28FN5O2/c1-28-16-13-21(26-28)29(15-6-4-2-3-5-7-23(30)27-31)22-17-19(12-14-25-22)18-8-10-20(24)11-9-18/h8-14,16-17,31H,2-7,15H2,1H3,(H,27,30)
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Karus Therapeutics Limited

US Patent


Assay Description
The assay is described in WO2008/062201.


US Patent US10150763 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (human))
BDBM310734
PNG
(8-((5-Fluoropyridin-2-yl)(3-(trifluoromethyl)1,2,4...)
Show SMILES ONC(=O)CCCCCCCN(c1nc(ns1)C(F)(F)F)c1ccc(F)cn1
Show InChI InChI=1S/C16H19F4N5O2S/c17-11-7-8-12(21-10-11)25(15-22-14(24-28-15)16(18,19)20)9-5-3-1-2-4-6-13(26)23-27/h7-8,10,27H,1-6,9H2,(H,23,26)
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Karus Therapeutics Limited

US Patent


Assay Description
The assay is described in WO2008/062201.


US Patent US10150763 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM310729
PNG
(7-((5-Fluoropyridin-2-yl)(3-methyl-1,2,4-thiadiazo...)
Show SMILES Cc1nsc(n1)N(CCCCCCC(=O)NO)c1ccc(F)cn1
Show InChI InChI=1S/C15H20FN5O2S/c1-11-18-15(24-20-11)21(13-8-7-12(16)10-17-13)9-5-3-2-4-6-14(22)19-23/h7-8,10,23H,2-6,9H2,1H3,(H,19,22)
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Karus Therapeutics Limited

US Patent


Assay Description
The assay is described in WO2008/062201.


US Patent US10150763 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM310709
PNG
(N-Hydroxy-7-((5-methyl-1,3,4-thiadiazol-2-yl)(pyri...)
Show SMILES Cc1nnc(s1)N(CCCCCCC(=O)NO)c1ccccn1
Show InChI InChI=1S/C15H21N5O2S/c1-12-17-18-15(23-12)20(13-8-5-6-10-16-13)11-7-3-2-4-9-14(21)19-22/h5-6,8,10,22H,2-4,7,9,11H2,1H3,(H,19,21)
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Karus Therapeutics Limited

US Patent


Assay Description
The assay is described in WO2008/062201.


US Patent US10150763 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM310733
PNG
(7-((5-Fluoropyridin-2-yl)(3-(trifluoromethyl)1,2,4...)
Show SMILES ONC(=O)CCCCCCN(c1nc(ns1)C(F)(F)F)c1ccc(F)cn1
Show InChI InChI=1S/C15H17F4N5O2S/c16-10-6-7-11(20-9-10)24(8-4-2-1-3-5-12(25)22-26)14-21-13(23-27-14)15(17,18)19/h6-7,9,26H,1-5,8H2,(H,22,25)
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Karus Therapeutics Limited

US Patent


Assay Description
The assay is described in WO2008/062201.


US Patent US10150763 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM310715
PNG
(N-Hydroxy-7-(pyridin-2-yl(1,2,4-thiadiazol-5-yl)am...)
Show SMILES ONC(=O)CCCCCCN(c1ncns1)c1ccccn1
Show InChI InChI=1S/C14H19N5O2S/c20-13(18-21)8-3-1-2-6-10-19(14-16-11-17-22-14)12-7-4-5-9-15-12/h4-5,7,9,11,21H,1-3,6,8,10H2,(H,18,20)
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Karus Therapeutics Limited

US Patent


Assay Description
The assay is described in WO2008/062201.


US Patent US10150763 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM310719
PNG
(7-((5-Fluoropyridin-2-yl)(1-methyl-1H-benzo[d]imid...)
Show SMILES Cn1c(nc2ccccc12)N(CCCCCCC(=O)NO)c1ccc(F)cn1
Show InChI InChI=1S/C20H24FN5O2/c1-25-17-9-6-5-8-16(17)23-20(25)26(18-12-11-15(21)14-22-18)13-7-3-2-4-10-19(27)24-28/h5-6,8-9,11-12,14,28H,2-4,7,10,13H2,1H3,(H,24,27)
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Karus Therapeutics Limited

US Patent


Assay Description
The assay is described in WO2008/062201.


US Patent US10150763 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM310736
PNG
(8-(Benzo[d]thiazol-2-yl(pyridin-2-yl)amino)-N-hydr...)
Show SMILES ONC(=O)CCCCCCCN(c1nc2ccccc2s1)c1ccccn1
Show InChI InChI=1S/C20H24N4O2S/c25-19(23-26)13-4-2-1-3-9-15-24(18-12-7-8-14-21-18)20-22-16-10-5-6-11-17(16)27-20/h5-8,10-12,14,26H,1-4,9,13,15H2,(H,23,25)
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Karus Therapeutics Limited

US Patent


Assay Description
The assay is described in WO2008/062201.


US Patent US10150763 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM310727
PNG
(7-((5-Fluoropyridin-2-yl)(3-(trifluoromethyl)1,2,4...)
Show SMILES ONC(=O)CCCCCCN(c1nc(ns1)C(F)(F)F)c1ccccn1
Show InChI InChI=1S/C15H18F3N5O2S/c16-15(17,18)13-20-14(26-22-13)23(11-7-4-5-9-19-11)10-6-2-1-3-8-12(24)21-25/h4-5,7,9,25H,1-3,6,8,10H2,(H,21,24)
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Karus Therapeutics Limited

US Patent


Assay Description
The assay is described in WO2008/062201.


US Patent US10150763 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM310738
PNG
(US10150763, Example LL)
Show SMILES ONC(=O)CCCCCCCN(c1nccs1)c1ccccn1
Show InChI InChI=1S/C16H22N4O2S/c21-15(19-22)9-4-2-1-3-7-12-20(16-18-11-13-23-16)14-8-5-6-10-17-14/h5-6,8,10-11,13,22H,1-4,7,9,12H2,(H,19,21)
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Karus Therapeutics Limited

US Patent


Assay Description
The assay is described in WO2008/062201.


US Patent US10150763 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM310731
PNG
(7-((4-(4-Fluorophenyl)pyridin-2-yl)(3-methyl-1,2,4...)
Show SMILES Cc1nsc(n1)N(CCCCCCC(=O)NO)c1cc(ccn1)-c1ccc(F)cc1
Show InChI InChI=1S/C21H24FN5O2S/c1-15-24-21(30-26-15)27(13-5-3-2-4-6-20(28)25-29)19-14-17(11-12-23-19)16-7-9-18(22)10-8-16/h7-12,14,29H,2-6,13H2,1H3,(H,25,28)
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Karus Therapeutics Limited

US Patent


Assay Description
The assay is described in WO2008/062201.


US Patent US10150763 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM310710
PNG
(N-Hydroxy-8-((5-methyl-1,3,4-thiadiazol-2-yl)(pyri...)
Show SMILES Cc1nnc(s1)N(CCCCCCCC(=O)NO)c1ccccn1
Show InChI InChI=1S/C16H23N5O2S/c1-13-18-19-16(24-13)21(14-9-6-7-11-17-14)12-8-4-2-3-5-10-15(22)20-23/h6-7,9,11,23H,2-5,8,10,12H2,1H3,(H,20,22)
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Karus Therapeutics Limited

US Patent


Assay Description
The assay is described in WO2008/062201.


US Patent US10150763 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM310734
PNG
(8-((5-Fluoropyridin-2-yl)(3-(trifluoromethyl)1,2,4...)
Show SMILES ONC(=O)CCCCCCCN(c1nc(ns1)C(F)(F)F)c1ccc(F)cn1
Show InChI InChI=1S/C16H19F4N5O2S/c17-11-7-8-12(21-10-11)25(15-22-14(24-28-15)16(18,19)20)9-5-3-1-2-4-6-13(26)23-27/h7-8,10,27H,1-6,9H2,(H,23,26)
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Karus Therapeutics Limited

US Patent


Assay Description
The assay is described in WO2008/062201.


US Patent US10150763 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM310730
PNG
(8-((5-Fluoropyridin-2-yl)(3-methyl-1,2,4-thiadiazo...)
Show SMILES Cc1nsc(n1)N(CCCCCCCC(=O)NO)c1ccc(F)cn1
Show InChI InChI=1S/C16H22FN5O2S/c1-12-19-16(25-21-12)22(14-9-8-13(17)11-18-14)10-6-4-2-3-5-7-15(23)20-24/h8-9,11,24H,2-7,10H2,1H3,(H,20,23)
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Karus Therapeutics Limited

US Patent


Assay Description
The assay is described in WO2008/062201.


US Patent US10150763 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM310721
PNG
(7-((5-Fluoropyridin-2-yl)(1-methyl-1H-pyrazol-3-yl...)
Show SMILES Cn1ccc(n1)N(CCCCCCC(=O)NO)c1ccc(F)cn1
Show InChI InChI=1S/C16H22FN5O2/c1-21-11-9-15(19-21)22(14-8-7-13(17)12-18-14)10-5-3-2-4-6-16(23)20-24/h7-9,11-12,24H,2-6,10H2,1H3,(H,20,23)
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Karus Therapeutics Limited

US Patent


Assay Description
The assay is described in WO2008/062201.


US Patent US10150763 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM310735
PNG
(7-(Benzo[d]thiazol-2-yl(pyridin-2-yl)amino)-N-hydr...)
Show SMILES ONC(=O)CCCCCCN(c1nc2ccccc2s1)c1ccccn1
Show InChI InChI=1S/C19H22N4O2S/c24-18(22-25)12-3-1-2-8-14-23(17-11-6-7-13-20-17)19-21-15-9-4-5-10-16(15)26-19/h4-7,9-11,13,25H,1-3,8,12,14H2,(H,22,24)
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Karus Therapeutics Limited

US Patent


Assay Description
The assay is described in WO2008/062201.


US Patent US10150763 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM310706
PNG
(N-Hydroxy-8-((1-methyl-1H-pyrazol-3-yl)(pyridin-2-...)
Show SMILES Cn1ccc(n1)N(CCCCCCCC(=O)NO)c1ccccn1
Show InChI InChI=1S/C17H25N5O2/c1-21-14-11-16(19-21)22(15-9-6-7-12-18-15)13-8-4-2-3-5-10-17(23)20-24/h6-7,9,11-12,14,24H,2-5,8,10,13H2,1H3,(H,20,23)
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Karus Therapeutics Limited

US Patent


Assay Description
The assay is described in WO2008/062201.


US Patent US10150763 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM310714
PNG
(N-Hydroxy-8-((1-methyl-1H-benzo[d]imidazol-2-yl)(p...)
Show SMILES Cn1c(nc2ccccc12)N(CCCCCCCC(=O)NO)c1ccccn1
Show InChI InChI=1S/C21H27N5O2/c1-25-18-12-7-6-11-17(18)23-21(25)26(19-13-8-9-15-22-19)16-10-4-2-3-5-14-20(27)24-28/h6-9,11-13,15,28H,2-5,10,14,16H2,1H3,(H,24,27)
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Karus Therapeutics Limited

US Patent


Assay Description
The assay is described in WO2008/062201.


US Patent US10150763 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM310723
PNG
(7-(Benzo[d]oxazol-2-yl(5-fluoropyridin-2-yl)amino)...)
Show SMILES ONC(=O)CCCCCCN(c1nc2ccccc2o1)c1ccc(F)cn1
Show InChI InChI=1S/C19H21FN4O3/c20-14-10-11-17(21-13-14)24(12-6-2-1-3-9-18(25)23-26)19-22-15-7-4-5-8-16(15)27-19/h4-5,7-8,10-11,13,26H,1-3,6,9,12H2,(H,23,25)
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Karus Therapeutics Limited

US Patent


Assay Description
The assay is described in WO2008/062201.


US Patent US10150763 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM310708
PNG
(N-Hydroxy-8-(pyridin-2-yl(1,3,4-thiadiazol-2-yl)am...)
Show SMILES ONC(=O)CCCCCCCN(c1nncs1)c1ccccn1
Show InChI InChI=1S/C15H21N5O2S/c21-14(19-22)9-4-2-1-3-7-11-20(15-18-17-12-23-15)13-8-5-6-10-16-13/h5-6,8,10,12,22H,1-4,7,9,11H2,(H,19,21)
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Karus Therapeutics Limited

US Patent


Assay Description
The assay is described in WO2008/062201.


US Patent US10150763 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM310704
PNG
(N-Hydroxy-8-((3-methyl-1,2,4-oxadiazol-5-yl)(pyrid...)
Show SMILES Cc1noc(n1)N(CCCCCCCC(=O)NO)c1ccccn1
Show InChI InChI=1S/C16H23N5O3/c1-13-18-16(24-20-13)21(14-9-6-7-11-17-14)12-8-4-2-3-5-10-15(22)19-23/h6-7,9,11,23H,2-5,8,10,12H2,1H3,(H,19,22)
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Karus Therapeutics Limited

US Patent


Assay Description
The assay is described in WO2008/062201.


US Patent US10150763 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM310737
PNG
(N-Hydroxy-7-(pyridin-2-yl(thiazol-2-yl)amino)hepta...)
Show SMILES ONC(=O)CCCCCCN(c1nccs1)c1ccccn1
Show InChI InChI=1S/C15H20N4O2S/c20-14(18-21)8-3-1-2-6-11-19(15-17-10-12-22-15)13-7-4-5-9-16-13/h4-5,7,9-10,12,21H,1-3,6,8,11H2,(H,18,20)
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Karus Therapeutics Limited

US Patent


Assay Description
The assay is described in WO2008/062201.


US Patent US10150763 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM310716
PNG
(N-Hydroxy-8-(pyridin-2-yl(1,2,4-thiadiazol-5-yl)am...)
Show SMILES ONC(=O)CCCCCCCN(c1ncns1)c1ccccn1
Show InChI InChI=1S/C15H21N5O2S/c21-14(19-22)9-4-2-1-3-7-11-20(15-17-12-18-23-15)13-8-5-6-10-16-13/h5-6,8,10,12,22H,1-4,7,9,11H2,(H,19,21)
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Karus Therapeutics Limited

US Patent


Assay Description
The assay is described in WO2008/062201.


US Patent US10150763 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM310718
PNG
(8-((5-Fluoropyridin-2-yl)(3-methyl-1,2,4-oxadiazol...)
Show SMILES Cc1noc(n1)N(CCCCCCCC(=O)NO)c1ccc(F)cn1
Show InChI InChI=1S/C16H22FN5O3/c1-12-19-16(25-21-12)22(14-9-8-13(17)11-18-14)10-6-4-2-3-5-7-15(23)20-24/h8-9,11,24H,2-7,10H2,1H3,(H,20,23)
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n/an/a 5.50E+3n/an/an/an/an/an/a



Karus Therapeutics Limited

US Patent


Assay Description
The assay is described in WO2008/062201.


US Patent US10150763 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM310720
PNG
(8-((5-Fluoropyridin-2-yl)(1-methyl-1H-benzo[d]imid...)
Show SMILES Cn1c(nc2ccccc12)N(CCCCCCC(=O)C(=O)NO)c1ccc(F)cn1
Show InChI InChI=1S/C21H24FN5O3/c1-26-17-9-6-5-8-16(17)24-21(26)27(19-12-11-15(22)14-23-19)13-7-3-2-4-10-18(28)20(29)25-30/h5-6,8-9,11-12,14,30H,2-4,7,10,13H2,1H3,(H,25,29)
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Karus Therapeutics Limited

US Patent


Assay Description
The assay is described in WO2008/062201.


US Patent US10150763 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM310732
PNG
(8-((4-(4-Fluorophenyl)-pyridin-2-yl)(3-methyl-1,2,...)
Show SMILES Cc1nsc(n1)N(CCCCCCCC(=O)NO)c1cc(ccn1)-c1ccc(F)cc1
Show InChI InChI=1S/C22H26FN5O2S/c1-16-25-22(31-27-16)28(14-6-4-2-3-5-7-21(29)26-30)20-15-18(12-13-24-20)17-8-10-19(23)11-9-17/h8-13,15,30H,2-7,14H2,1H3,(H,26,29)
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Karus Therapeutics Limited

US Patent


Assay Description
The assay is described in WO2008/062201.


US Patent US10150763 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM310713
PNG
(N-Hydroxy-7-((1-methyl-1H-benzo[d]imidazol-2-yl)(p...)
Show SMILES Cn1c(nc2ccccc12)N(CCCCCCC(=O)NO)c1ccccn1
Show InChI InChI=1S/C20H25N5O2/c1-24-17-11-6-5-10-16(17)22-20(24)25(18-12-7-8-14-21-18)15-9-3-2-4-13-19(26)23-27/h5-8,10-12,14,27H,2-4,9,13,15H2,1H3,(H,23,26)
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Karus Therapeutics Limited

US Patent


Assay Description
The assay is described in WO2008/062201.


US Patent US10150763 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM310724
PNG
(8-(Benzo[d]oxazol-2-yl(5-fluoropyridin-2-yl)amino)...)
Show SMILES ONC(=O)CCCCCCCN(c1nc2ccccc2o1)c1ccc(F)cn1
Show InChI InChI=1S/C20H23FN4O3/c21-15-11-12-18(22-14-15)25(13-7-3-1-2-4-10-19(26)24-27)20-23-16-8-5-6-9-17(16)28-20/h5-6,8-9,11-12,14,27H,1-4,7,10,13H2,(H,24,26)
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n/an/a 5.50E+3n/an/an/an/an/an/a



Karus Therapeutics Limited

US Patent


Assay Description
The assay is described in WO2008/062201.


US Patent US10150763 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM310726
PNG
(8-((4-(4-Fluorophenyl)pyridin-2-yl)(1-methyl-1H-py...)
Show SMILES Cn1ccc(n1)N(CCCCCCCC(=O)NO)c1cc(ccn1)-c1ccc(F)cc1
Show InChI InChI=1S/C23H28FN5O2/c1-28-16-13-21(26-28)29(15-6-4-2-3-5-7-23(30)27-31)22-17-19(12-14-25-22)18-8-10-20(24)11-9-18/h8-14,16-17,31H,2-7,15H2,1H3,(H,27,30)
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Karus Therapeutics Limited

US Patent


Assay Description
The assay is described in WO2008/062201.


US Patent US10150763 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM310722
PNG
(8-((5-Fluoropyridin-2-yl)(1-methyl-1H-pyrazol-3-yl...)
Show SMILES Cn1ccc(n1)N(CCCCCCCC(=O)NO)c1ccc(F)cn1
Show InChI InChI=1S/C17H24FN5O2/c1-22-12-10-16(20-22)23(15-9-8-14(18)13-19-15)11-6-4-2-3-5-7-17(24)21-25/h8-10,12-13,25H,2-7,11H2,1H3,(H,21,24)
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Karus Therapeutics Limited

US Patent


Assay Description
The assay is described in WO2008/062201.


US Patent US10150763 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM310717
PNG
(7-((5-Fluoropyridin-2-yl)(3-methyl-1,2,4-oxadiazol...)
Show SMILES Cc1noc(n1)N(CCCCCCC(=O)NO)c1ccc(F)cn1
Show InChI InChI=1S/C15H20FN5O3/c1-11-18-15(24-20-11)21(13-8-7-12(16)10-17-13)9-5-3-2-4-6-14(22)19-23/h7-8,10,23H,2-6,9H2,1H3,(H,19,22)
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Karus Therapeutics Limited

US Patent


Assay Description
The assay is described in WO2008/062201.


US Patent US10150763 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM310728
PNG
(8-((5-Fluoropyridin-2-yl)(3-(trifluoromethyl)1,2,4...)
Show SMILES ONC(=O)CCCCCCCN(c1nc(ns1)C(F)(F)F)c1ccccn1
Show InChI InChI=1S/C16H20F3N5O2S/c17-16(18,19)14-21-15(27-23-14)24(12-8-5-6-10-20-12)11-7-3-1-2-4-9-13(25)22-26/h5-6,8,10,26H,1-4,7,9,11H2,(H,22,25)
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Karus Therapeutics Limited

US Patent


Assay Description
The assay is described in WO2008/062201.


US Patent US10150763 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM310712
PNG
(8-(Benzo[d]oxazol-2-yl(pyridin-2-yl)amino)-N-hydro...)
Show SMILES ONC(=O)CCCCCCCN(c1nc2ccccc2o1)c1ccccn1
Show InChI InChI=1S/C20H24N4O3/c25-19(23-26)13-4-2-1-3-9-15-24(18-12-7-8-14-21-18)20-22-16-10-5-6-11-17(16)27-20/h5-8,10-12,14,26H,1-4,9,13,15H2,(H,23,25)
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Karus Therapeutics Limited

US Patent


Assay Description
The assay is described in WO2008/062201.


US Patent US10150763 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%