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Patent code US10150766

Compile Data Set for Download or QSAR
Found 102 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM310833
PNG
(US10150766, Example 25)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1ccn[nH]1)N3C(=O)c1ccc(F)c(Cl)c1Cl
PDB

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20n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM310870
PNG
(US10150766, Example 64)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1ccccn1)N3C(=O)c1ccc(Cl)c(F)c1Cl
Show InChI InChI=1S/C23H19Cl2FN4O/c1-12-28-21(17-6-2-3-10-27-17)15-11-13-5-4-7-18(22(15)29-12)30(13)23(31)14-8-9-16(24)20(26)19(14)25/h2-3,6,8-10,13,18H,4-5,7,11H2,1H3/t13-,18+/m0/s1
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20n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM310837
PNG
(US10150766, Example 29)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1ccn[nH]1)N3C(=O)c1cccc(Cl)c1Cl
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20n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM310811
PNG
(US10150766, Example 2)
Show SMILES Cc1nc2C3CCCC(Cc2c(n1)-c1ccn[nH]1)N3C(=O)c1cccc(c1Cl)C(F)(F)F
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22.4n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM310854
PNG
(US10150766, Example 48)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1cnccn1)N3C(=O)c1cccc(Cl)c1Cl
Show InChI InChI=1S/C22H19Cl2N5O/c1-12-27-20(17-11-25-8-9-26-17)15-10-13-4-2-7-18(21(15)28-12)29(13)22(30)14-5-3-6-16(23)19(14)24/h3,5-6,8-9,11,13,18H,2,4,7,10H2,1H3/t13-,18+/m0/s1
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25.1n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM310851
PNG
(US10150766, Example 45)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1ncccn1)N3C(=O)c1cccc(Cl)c1Cl
Show InChI InChI=1S/C22H19Cl2N5O/c1-12-27-19-15(20(28-12)21-25-9-4-10-26-21)11-13-5-2-8-17(19)29(13)22(30)14-6-3-7-16(23)18(14)24/h3-4,6-7,9-10,13,17H,2,5,8,11H2,1H3/t13-,17+/m0/s1
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25.1n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM310847
PNG
(US10150766, Example 41)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1ncccn1)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C23H19ClF3N5O/c1-12-30-19-15(20(31-12)21-28-9-4-10-29-21)11-13-5-2-8-17(19)32(13)22(33)14-6-3-7-16(18(14)24)23(25,26)27/h3-4,6-7,9-10,13,17H,2,5,8,11H2,1H3/t13-,17+/m0/s1
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29.5n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM310852
PNG
(US10150766, Example 46)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1cnccn1)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C23H19ClF3N5O/c1-12-30-20(17-11-28-8-9-29-17)15-10-13-4-2-7-18(21(15)31-12)32(13)22(33)14-5-3-6-16(19(14)24)23(25,26)27/h3,5-6,8-9,11,13,18H,2,4,7,10H2,1H3/t13-,18+/m0/s1
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31.6n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM310810
PNG
(US10150766, Example 1)
Show SMILES Cc1nc2C3CCCC(Cc2c(n1)-c1ccn[nH]1)N3C(=O)c1cccc(Cl)c1Cl
PDB

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31.6n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM310859
PNG
(US10150766, Example 53)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1ccc(F)cc1)N3C(=O)c1cccc(c1C)C(F)(F)F
Show InChI InChI=1S/C26H23F4N3O/c1-14-19(6-4-7-21(14)26(28,29)30)25(34)33-18-5-3-8-22(33)24-20(13-18)23(31-15(2)32-24)16-9-11-17(27)12-10-16/h4,6-7,9-12,18,22H,3,5,8,13H2,1-2H3/t18-,22+/m0/s1
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31.6n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM310829
PNG
(US10150766, Example 21)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1ccn[nH]1)N3C(=O)c1cccc(c1C)C(F)(F)F
PDB

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31.6n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM310831
PNG
(US10150766, Example 23)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1ccn[nH]1)N3C(=O)c1ccc(Cl)c(F)c1Cl
PDB

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31.6n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM310827
PNG
(US10150766, Example 19)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1ccn[nH]1)N3C(=O)c1cccc(c1Cl)C(F)(F)F
PDB

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33.1n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM310853
PNG
(US10150766, Example 47)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1cnccn1)N3C(=O)c1ccc(Cl)c(F)c1Cl
Show InChI InChI=1S/C22H18Cl2FN5O/c1-11-28-20(16-10-26-7-8-27-16)14-9-12-3-2-4-17(21(14)29-11)30(12)22(31)13-5-6-15(23)19(25)18(13)24/h5-8,10,12,17H,2-4,9H2,1H3/t12-,17+/m0/s1
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39.8n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM310869
PNG
(US10150766, Example 63)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1ccccn1)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C24H20ClF3N4O/c1-13-30-21(18-9-2-3-11-29-18)16-12-14-6-4-10-19(22(16)31-13)32(14)23(33)15-7-5-8-17(20(15)25)24(26,27)28/h2-3,5,7-9,11,14,19H,4,6,10,12H2,1H3/t14-,19+/m0/s1
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39.8n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM310857
PNG
(US10150766, Example 51)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1ccc(F)cc1)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C25H20ClF4N3O/c1-13-31-22(14-8-10-15(27)11-9-14)18-12-16-4-2-7-20(23(18)32-13)33(16)24(34)17-5-3-6-19(21(17)26)25(28,29)30/h3,5-6,8-11,16,20H,2,4,7,12H2,1H3/t16-,20+/m0/s1
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44.7n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM310871
PNG
(US10150766, Example 65)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1ccccn1)N3C(=O)c1cccc(Cl)c1Cl
Show InChI InChI=1S/C23H20Cl2N4O/c1-13-27-21(18-9-2-3-11-26-18)16-12-14-6-4-10-19(22(16)28-13)29(14)23(30)15-7-5-8-17(24)20(15)25/h2-3,5,7-9,11,14,19H,4,6,10,12H2,1H3/t14-,19+/m0/s1
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49n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM310850
PNG
(US10150766, Example 44)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1ncccn1)N3C(=O)c1ccc(Cl)c(F)c1Cl
Show InChI InChI=1S/C22H18Cl2FN5O/c1-11-28-19-14(20(29-11)21-26-8-3-9-27-21)10-12-4-2-5-16(19)30(12)22(31)13-6-7-15(23)18(25)17(13)24/h3,6-9,12,16H,2,4-5,10H2,1H3/t12-,16+/m0/s1
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50.1n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM310858
PNG
(US10150766, Example 52)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1ccc(F)cc1)N3C(=O)c1ccnc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C24H19ClF4N4O/c1-12-31-20(13-5-7-14(26)8-6-13)17-11-15-3-2-4-18(21(17)32-12)33(15)23(34)16-9-10-30-22(19(16)25)24(27,28)29/h5-10,15,18H,2-4,11H2,1H3/t15-,18+/m0/s1
PDB

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60.3n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM310834
PNG
(US10150766, Example 26)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1ccn[nH]1)N3C(=O)c1cccc(c1F)C(F)(F)F
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63.1n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM310868
PNG
(US10150766, Example 62)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1ccccn1)N3C(=O)c1cccc(c1C)C(F)(F)F
Show InChI InChI=1S/C25H23F3N4O/c1-14-17(8-6-9-19(14)25(26,27)28)24(33)32-16-7-5-11-21(32)23-18(13-16)22(30-15(2)31-23)20-10-3-4-12-29-20/h3-4,6,8-10,12,16,21H,5,7,11,13H2,1-2H3/t16-,21+/m0/s1
PDB

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63.1n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM310860
PNG
(US10150766, Example 54)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1ccc(F)cc1)N3C(=O)c1ccc(Cl)c(F)c1Cl
Show InChI InChI=1S/C24H19Cl2F2N3O/c1-12-29-22(13-5-7-14(27)8-6-13)17-11-15-3-2-4-19(23(17)30-12)31(15)24(32)16-9-10-18(25)21(28)20(16)26/h5-10,15,19H,2-4,11H2,1H3/t15-,19+/m0/s1
PDB

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72.4n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM310867
PNG
(US10150766, Example 61)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1ccccn1)N3C(=O)c1ccnc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C23H19ClF3N5O/c1-12-30-19(16-6-2-3-9-28-16)15-11-13-5-4-7-17(20(15)31-12)32(13)22(33)14-8-10-29-21(18(14)24)23(25,26)27/h2-3,6,8-10,13,17H,4-5,7,11H2,1H3/t13-,17+/m0/s1
PDB

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93.3n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM310856
PNG
(US10150766, Example 50)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1cnccn1)N3C(=O)c1cccc(c1C)C(F)(F)F
Show InChI InChI=1S/C24H22F3N5O/c1-13-16(6-4-7-18(13)24(25,26)27)23(33)32-15-5-3-8-20(32)22-17(11-15)21(30-14(2)31-22)19-12-28-9-10-29-19/h4,6-7,9-10,12,15,20H,3,5,8,11H2,1-2H3/t15-,20+/m0/s1
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93.3n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM310864
PNG
(US10150766, Example 58)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1ccnn1C)N3C(=O)c1ccc(Cl)c(F)c1Cl
Show InChI InChI=1S/C22H20Cl2FN5O/c1-11-27-20(16-8-9-26-29(16)2)14-10-12-4-3-5-17(21(14)28-11)30(12)22(31)13-6-7-15(23)19(25)18(13)24/h6-9,12,17H,3-5,10H2,1-2H3/t12-,17+/m0/s1
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93.3n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM310862
PNG
(US10150766, Example 56)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1ccnn1C)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C23H21ClF3N5O/c1-12-29-20(17-9-10-28-31(17)2)15-11-13-5-3-8-18(21(15)30-12)32(13)22(33)14-6-4-7-16(19(14)24)23(25,26)27/h4,6-7,9-10,13,18H,3,5,8,11H2,1-2H3/t13-,18+/m0/s1
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100n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM310861
PNG
(US10150766, Example 55)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1ccc(F)cc1)N3C(=O)c1cccc(Cl)c1Cl
Show InChI InChI=1S/C24H20Cl2FN3O/c1-13-28-22(14-8-10-15(27)11-9-14)18-12-16-4-2-7-20(23(18)29-13)30(16)24(31)17-5-3-6-19(25)21(17)26/h3,5-6,8-11,16,20H,2,4,7,12H2,1H3/t16-,20+/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM310828
PNG
(US10150766, Example 20)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1ccn[nH]1)N3C(=O)c1ccc(Cl)cc1Cl
PDB

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120n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM310836
PNG
(US10150766, Example 28)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1ccn[nH]1)N3C(=O)c1ccc(Cl)cc1F
PDB

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Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM310832
PNG
(US10150766, Example 24)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1ccn[nH]1)N3C(=O)c1ccnc(c1Cl)C(F)(F)F
PDB

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126n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM310848
PNG
(US10150766, Example 42)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1ncccn1)N3C(=O)c1ccnc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C22H18ClF3N6O/c1-11-30-17-14(18(31-11)20-28-7-3-8-29-20)10-12-4-2-5-15(17)32(12)21(33)13-6-9-27-19(16(13)23)22(24,25)26/h3,6-9,12,15H,2,4-5,10H2,1H3/t12-,15+/m0/s1
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126n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM310849
PNG
(US10150766, Example 43)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1ncccn1)N3C(=O)c1cccc(c1C)C(F)(F)F
Show InChI InChI=1S/C24H22F3N5O/c1-13-16(7-4-8-18(13)24(25,26)27)23(33)32-15-6-3-9-19(32)20-17(12-15)21(31-14(2)30-20)22-28-10-5-11-29-22/h4-5,7-8,10-11,15,19H,3,6,9,12H2,1-2H3/t15-,19+/m0/s1
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126n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM310865
PNG
(US10150766, Example 59)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1ccnn1C)N3C(=O)c1cccc(Cl)c1Cl
Show InChI InChI=1S/C22H21Cl2N5O/c1-12-26-20(17-9-10-25-28(17)2)15-11-13-5-3-8-18(21(15)27-12)29(13)22(30)14-6-4-7-16(23)19(14)24/h4,6-7,9-10,13,18H,3,5,8,11H2,1-2H3/t13-,18+/m0/s1
PDB

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135n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM310835
PNG
(US10150766, Example 27)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1ccn[nH]1)N3C(=O)c1ccnc(c1F)C(F)(F)F
PDB

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151n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM310863
PNG
(US10150766, Example 57)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1ccnn1C)N3C(=O)c1cccc(c1C)C(F)(F)F
Show InChI InChI=1S/C24H24F3N5O/c1-13-16(7-5-8-18(13)24(25,26)27)23(33)32-15-6-4-9-20(32)22-17(12-15)21(29-14(2)30-22)19-10-11-28-31(19)3/h5,7-8,10-11,15,20H,4,6,9,12H2,1-3H3/t15-,20+/m0/s1
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190n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM310855
PNG
(US10150766, Example 49)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1cnccn1)N3C(=O)c1ccnc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C22H18ClF3N6O/c1-11-30-18(15-10-27-7-8-28-15)14-9-12-3-2-4-16(19(14)31-11)32(12)21(33)13-5-6-29-20(17(13)23)22(24,25)26/h5-8,10,12,16H,2-4,9H2,1H3/t12-,16+/m0/s1
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200n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM310838
PNG
(US10150766, Example 30)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1cnn(C)c1)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C23H21ClF3N5O/c1-12-29-20(13-10-28-31(2)11-13)16-9-14-5-3-8-18(21(16)30-12)32(14)22(33)15-6-4-7-17(19(15)24)23(25,26)27/h4,6-7,10-11,14,18H,3,5,8-9H2,1-2H3/t14-,18+/m0/s1
PDB

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251n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM310830
PNG
(US10150766, Example 22)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1ccn[nH]1)N3C(=O)c1ccc(F)cc1Cl
PDB

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316n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM310820
PNG
(US10150766, Example 11)
Show SMILES Cc1nc2[C@@H]3CCC[C@H](Cc2c(n1)-c1ccn[nH]1)N3C(=O)c1cccc(Cl)c1Cl
PDB

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501n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM310819
PNG
(US10150766, Example 10)
Show SMILES Cc1nc2[C@@H]3CCC[C@H](Cc2c(n1)-c1ccn[nH]1)N3C(=O)c1ccc(Cl)c(F)c1Cl
PDB

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631n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM310862
PNG
(US10150766, Example 56)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1ccnn1C)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C23H21ClF3N5O/c1-12-29-20(17-9-10-28-31(17)2)15-11-13-5-3-8-18(21(15)30-12)32(13)22(33)14-6-4-7-16(19(14)24)23(25,26)27/h4,6-7,9-10,13,18H,3,5,8,11H2,1-2H3/t13-,18+/m0/s1
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n/an/a 11.6n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM310827
PNG
(US10150766, Example 19)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1ccn[nH]1)N3C(=O)c1cccc(c1Cl)C(F)(F)F
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Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM310852
PNG
(US10150766, Example 46)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1cnccn1)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C23H19ClF3N5O/c1-12-30-20(17-11-28-8-9-29-17)15-10-13-4-2-7-18(21(15)31-12)32(13)22(33)14-5-3-6-16(19(14)24)23(25,26)27/h3,5-6,8-9,11,13,18H,2,4,7,10H2,1H3/t13-,18+/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM310847
PNG
(US10150766, Example 41)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1ncccn1)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C23H19ClF3N5O/c1-12-30-19-15(20(31-12)21-28-9-4-10-29-21)11-13-5-2-8-17(19)32(13)22(33)14-6-3-7-16(18(14)24)23(25,26)27/h3-4,6-7,9-10,13,17H,2,5,8,11H2,1H3/t13-,17+/m0/s1
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n/an/a 15.8n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM310857
PNG
(US10150766, Example 51)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1ccc(F)cc1)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C25H20ClF4N3O/c1-13-31-22(14-8-10-15(27)11-9-14)18-12-16-4-2-7-20(23(18)32-13)33(16)24(34)17-5-3-6-19(21(17)26)25(28,29)30/h3,5-6,8-11,16,20H,2,4,7,12H2,1H3/t16-,20+/m0/s1
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n/an/a 16.6n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM310833
PNG
(US10150766, Example 25)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1ccn[nH]1)N3C(=O)c1ccc(F)c(Cl)c1Cl
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Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM310832
PNG
(US10150766, Example 24)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1ccn[nH]1)N3C(=O)c1ccnc(c1Cl)C(F)(F)F
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Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM310869
PNG
(US10150766, Example 63)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1ccccn1)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C24H20ClF3N4O/c1-13-30-21(18-9-2-3-11-29-18)16-12-14-6-4-10-19(22(16)31-13)32(14)23(33)15-7-5-8-17(20(15)25)24(26,27)28/h2-3,5,7-9,11,14,19H,4,6,10,12H2,1H3/t14-,19+/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM310829
PNG
(US10150766, Example 21)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1ccn[nH]1)N3C(=O)c1cccc(c1C)C(F)(F)F
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Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM310834
PNG
(US10150766, Example 26)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1ccn[nH]1)N3C(=O)c1cccc(c1F)C(F)(F)F
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Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM310849
PNG
(US10150766, Example 43)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1ncccn1)N3C(=O)c1cccc(c1C)C(F)(F)F
Show InChI InChI=1S/C24H22F3N5O/c1-13-16(7-4-8-18(13)24(25,26)27)23(33)32-15-6-3-9-19(32)20-17(12-15)21(31-14(2)30-20)22-28-10-5-11-29-22/h4-5,7-8,10-11,15,19H,3,6,9,12H2,1-2H3/t15-,19+/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM310867
PNG
(US10150766, Example 61)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1ccccn1)N3C(=O)c1ccnc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C23H19ClF3N5O/c1-12-30-19(16-6-2-3-9-28-16)15-11-13-5-4-7-17(20(15)31-12)32(13)22(33)14-8-10-29-21(18(14)24)23(25,26)27/h2-3,6,8-10,13,17H,4-5,7,11H2,1H3/t13-,17+/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM310868
PNG
(US10150766, Example 62)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1ccccn1)N3C(=O)c1cccc(c1C)C(F)(F)F
Show InChI InChI=1S/C25H23F3N4O/c1-14-17(8-6-9-19(14)25(26,27)28)24(33)32-16-7-5-11-21(32)23-18(13-16)22(30-15(2)31-23)20-10-3-4-12-29-20/h3-4,6,8-10,12,16,21H,5,7,11,13H2,1-2H3/t16-,21+/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM310854
PNG
(US10150766, Example 48)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1cnccn1)N3C(=O)c1cccc(Cl)c1Cl
Show InChI InChI=1S/C22H19Cl2N5O/c1-12-27-20(17-11-25-8-9-26-17)15-10-13-4-2-7-18(21(15)28-12)29(13)22(30)14-5-3-6-16(23)19(14)24/h3,5-6,8-9,11,13,18H,2,4,7,10H2,1H3/t13-,18+/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM310856
PNG
(US10150766, Example 50)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1cnccn1)N3C(=O)c1cccc(c1C)C(F)(F)F
Show InChI InChI=1S/C24H22F3N5O/c1-13-16(6-4-7-18(13)24(25,26)27)23(33)32-15-5-3-8-20(32)22-17(11-15)21(30-14(2)31-22)19-12-28-9-10-29-19/h4,6-7,9-10,12,15,20H,3,5,8,11H2,1-2H3/t15-,20+/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM310858
PNG
(US10150766, Example 52)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1ccc(F)cc1)N3C(=O)c1ccnc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C24H19ClF4N4O/c1-12-31-20(13-5-7-14(26)8-6-13)17-11-15-3-2-4-18(21(17)32-12)33(15)23(34)16-9-10-30-22(19(16)25)24(27,28)29/h5-10,15,18H,2-4,11H2,1H3/t15-,18+/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM310822
PNG
(US10150766, Example 13)
Show SMILES Cc1nc2[C@@H]3CCC[C@H](Cc2c(n1)-c1ccc(F)cc1)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C25H20ClF4N3O/c1-13-31-22(14-8-10-15(27)11-9-14)18-12-16-4-2-7-20(23(18)32-13)33(16)24(34)17-5-3-6-19(21(17)26)25(28,29)30/h3,5-6,8-11,16,20H,2,4,7,12H2,1H3/t16-,20+/m1/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM310823
PNG
(US10150766, Example 15)
Show SMILES Cc1nc2[C@@H]3CCC[C@H](Cc2c(n1)-c1ccc(F)cc1)N3C(=O)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C24H20Cl2FN3O/c1-13-28-22(14-5-8-16(27)9-6-14)19-12-17-3-2-4-21(23(19)29-13)30(17)24(31)18-10-7-15(25)11-20(18)26/h5-11,17,21H,2-4,12H2,1H3/t17-,21+/m1/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM310810
PNG
(US10150766, Example 1)
Show SMILES Cc1nc2C3CCCC(Cc2c(n1)-c1ccn[nH]1)N3C(=O)c1cccc(Cl)c1Cl
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Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM310851
PNG
(US10150766, Example 45)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1ncccn1)N3C(=O)c1cccc(Cl)c1Cl
Show InChI InChI=1S/C22H19Cl2N5O/c1-12-27-19-15(20(28-12)21-25-9-4-10-26-21)11-13-5-2-8-17(19)29(13)22(30)14-6-3-7-16(23)18(14)24/h3-4,6-7,9-10,13,17H,2,5,8,11H2,1H3/t13-,17+/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM310835
PNG
(US10150766, Example 27)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1ccn[nH]1)N3C(=O)c1ccnc(c1F)C(F)(F)F
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Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM310855
PNG
(US10150766, Example 49)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1cnccn1)N3C(=O)c1ccnc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C22H18ClF3N6O/c1-11-30-18(15-10-27-7-8-28-15)14-9-12-3-2-4-16(19(14)31-11)32(12)21(33)13-5-6-29-20(17(13)23)22(24,25)26/h5-8,10,12,16H,2-4,9H2,1H3/t12-,16+/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM310848
PNG
(US10150766, Example 42)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1ncccn1)N3C(=O)c1ccnc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C22H18ClF3N6O/c1-11-30-17-14(18(31-11)20-28-7-3-8-29-20)10-12-4-2-5-15(17)32(12)21(33)13-6-9-27-19(16(13)23)22(24,25)26/h3,6-9,12,15H,2,4-5,10H2,1H3/t12-,15+/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM310871
PNG
(US10150766, Example 65)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1ccccn1)N3C(=O)c1cccc(Cl)c1Cl
Show InChI InChI=1S/C23H20Cl2N4O/c1-13-27-21(18-9-2-3-11-26-18)16-12-14-6-4-10-19(22(16)28-13)29(14)23(30)15-7-5-8-17(24)20(15)25/h2-3,5,7-9,11,14,19H,4,6,10,12H2,1H3/t14-,19+/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM310859
PNG
(US10150766, Example 53)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1ccc(F)cc1)N3C(=O)c1cccc(c1C)C(F)(F)F
Show InChI InChI=1S/C26H23F4N3O/c1-14-19(6-4-7-21(14)26(28,29)30)25(34)33-18-5-3-8-22(33)24-20(13-18)23(31-15(2)32-24)16-9-11-17(27)12-10-16/h4,6-7,9-12,18,22H,3,5,8,13H2,1-2H3/t18-,22+/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM310837
PNG
(US10150766, Example 29)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1ccn[nH]1)N3C(=O)c1cccc(Cl)c1Cl
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Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM310861
PNG
(US10150766, Example 55)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1ccc(F)cc1)N3C(=O)c1cccc(Cl)c1Cl
Show InChI InChI=1S/C24H20Cl2FN3O/c1-13-28-22(14-8-10-15(27)11-9-14)18-12-16-4-2-7-20(23(18)29-13)30(16)24(31)17-5-3-6-19(25)21(17)26/h3,5-6,8-11,16,20H,2,4,7,12H2,1H3/t16-,20+/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM310853
PNG
(US10150766, Example 47)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1cnccn1)N3C(=O)c1ccc(Cl)c(F)c1Cl
Show InChI InChI=1S/C22H18Cl2FN5O/c1-11-28-20(16-10-26-7-8-27-16)14-9-12-3-2-4-17(21(14)29-11)30(12)22(31)13-5-6-15(23)19(25)18(13)24/h5-8,10,12,17H,2-4,9H2,1H3/t12-,17+/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM310850
PNG
(US10150766, Example 44)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1ncccn1)N3C(=O)c1ccc(Cl)c(F)c1Cl
Show InChI InChI=1S/C22H18Cl2FN5O/c1-11-28-19-14(20(29-11)21-26-8-3-9-27-21)10-12-4-2-5-16(19)30(12)22(31)13-6-7-15(23)18(25)17(13)24/h3,6-9,12,16H,2,4-5,10H2,1H3/t12-,16+/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM310860
PNG
(US10150766, Example 54)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1ccc(F)cc1)N3C(=O)c1ccc(Cl)c(F)c1Cl
Show InChI InChI=1S/C24H19Cl2F2N3O/c1-12-29-22(13-5-7-14(27)8-6-13)17-11-15-3-2-4-19(23(17)30-12)31(15)24(32)16-9-10-18(25)21(28)20(16)26/h5-10,15,19H,2-4,11H2,1H3/t15-,19+/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM310870
PNG
(US10150766, Example 64)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1ccccn1)N3C(=O)c1ccc(Cl)c(F)c1Cl
Show InChI InChI=1S/C23H19Cl2FN4O/c1-12-28-21(17-6-2-3-10-27-17)15-11-13-5-4-7-18(22(15)29-12)30(13)23(31)14-8-9-16(24)20(26)19(14)25/h2-3,6,8-10,13,18H,4-5,7,11H2,1H3/t13-,18+/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM310831
PNG
(US10150766, Example 23)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1ccn[nH]1)N3C(=O)c1ccc(Cl)c(F)c1Cl
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Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM310863
PNG
(US10150766, Example 57)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1ccnn1C)N3C(=O)c1cccc(c1C)C(F)(F)F
Show InChI InChI=1S/C24H24F3N5O/c1-13-16(7-5-8-18(13)24(25,26)27)23(33)32-15-6-4-9-20(32)22-17(12-15)21(29-14(2)30-22)19-10-11-28-31(19)3/h5,7-8,10-11,15,20H,4,6,9,12H2,1-3H3/t15-,20+/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM310817
PNG
(US10150766, Example 8)
Show SMILES Cc1nc2[C@@H]3CCC[C@H](Cc2c(n1)-c1ccn[nH]1)N3C(=O)c1cccc(c1F)C(F)(F)F
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Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM310866
PNG
(US10150766, Example 60)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1ccnn1C)N3C(=O)c1ccnc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C22H20ClF3N6O/c1-11-29-18(15-7-9-28-31(15)2)14-10-12-4-3-5-16(19(14)30-11)32(12)21(33)13-6-8-27-20(17(13)23)22(24,25)26/h6-9,12,16H,3-5,10H2,1-2H3/t12-,16+/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM310864
PNG
(US10150766, Example 58)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1ccnn1C)N3C(=O)c1ccc(Cl)c(F)c1Cl
Show InChI InChI=1S/C22H20Cl2FN5O/c1-11-27-20(16-8-9-26-29(16)2)14-10-12-4-3-5-17(21(14)28-11)30(12)22(31)13-6-7-15(23)19(25)18(13)24/h6-9,12,17H,3-5,10H2,1-2H3/t12-,17+/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM310812
PNG
(US10150766, Example 3)
Show SMILES Cc1nc2[C@@H]3CCC[C@H](Cc2c(n1)-c1ccn[nH]1)N3C(=O)c1cccc(c1Cl)C(F)(F)F
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Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM310816
PNG
(US10150766, Example 7)
Show SMILES Cc1nc2[C@@H]3CCC[C@H](Cc2c(n1)-c1ccn[nH]1)N3C(=O)c1ccnc(c1Cl)C(F)(F)F
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Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM310820
PNG
(US10150766, Example 11)
Show SMILES Cc1nc2[C@@H]3CCC[C@H](Cc2c(n1)-c1ccn[nH]1)N3C(=O)c1cccc(Cl)c1Cl
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Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM310813
PNG
(US10150766, Example 4)
Show SMILES Cc1nc2[C@@H]3CCC[C@H](Cc2c(n1)-c1ccn[nH]1)N3C(=O)c1ccc(F)c(Cl)c1Cl
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Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM310815
PNG
(US10150766, Example 6)
Show SMILES Cc1nc2[C@@H]3CCC[C@H](Cc2c(n1)-c1ccn[nH]1)N3C(=O)c1cccc(c1C)C(F)(F)F
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Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM310865
PNG
(US10150766, Example 59)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1ccnn1C)N3C(=O)c1cccc(Cl)c1Cl
Show InChI InChI=1S/C22H21Cl2N5O/c1-12-26-20(17-9-10-25-28(17)2)15-11-13-5-3-8-18(21(15)27-12)29(13)22(30)14-6-4-7-16(23)19(14)24/h4,6-7,9-10,13,18H,3,5,8,11H2,1-2H3/t13-,18+/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM310825
PNG
(US10150766, Example 17)
Show SMILES Cc1nc2[C@@H]3CCC[C@H](Cc2c(n1)-c1ccc(F)cc1)N3C(=O)c1ccc(F)c(Cl)c1Cl
Show InChI InChI=1S/C24H19Cl2F2N3O/c1-12-29-22(13-5-7-14(27)8-6-13)17-11-15-3-2-4-19(23(17)30-12)31(15)24(32)16-9-10-18(28)21(26)20(16)25/h5-10,15,19H,2-4,11H2,1H3/t15-,19+/m1/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM310819
PNG
(US10150766, Example 10)
Show SMILES Cc1nc2[C@@H]3CCC[C@H](Cc2c(n1)-c1ccn[nH]1)N3C(=O)c1ccc(Cl)c(F)c1Cl
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Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM310836
PNG
(US10150766, Example 28)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1ccn[nH]1)N3C(=O)c1ccc(Cl)cc1F
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Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM310824
PNG
(US10150766, Example 16)
Show SMILES Cc1nc2[C@@H]3CCC[C@H](Cc2c(n1)-c1ccc(F)cc1)N3C(=O)c1ccc(F)cc1Cl
Show InChI InChI=1S/C24H20ClF2N3O/c1-13-28-22(14-5-7-15(26)8-6-14)19-12-17-3-2-4-21(23(19)29-13)30(17)24(31)18-10-9-16(27)11-20(18)25/h5-11,17,21H,2-4,12H2,1H3/t17-,21+/m1/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM310846
PNG
(US10150766, Example 39)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1cnn(C)c1)N3C(=O)c1cccc(c1C)C(F)(F)F
Show InChI InChI=1S/C24H24F3N5O/c1-13-17(7-5-8-19(13)24(25,26)27)23(33)32-16-6-4-9-20(32)22-18(10-16)21(29-14(2)30-22)15-11-28-31(3)12-15/h5,7-8,11-12,16,20H,4,6,9-10H2,1-3H3/t16-,20+/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM310826
PNG
(US10150766, Example 18)
Show SMILES Cc1nc2[C@@H]3CCC[C@H](Cc2c(n1)-c1ccc(F)cc1)N3C(=O)c1ccnc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C24H19ClF4N4O/c1-12-31-20(13-5-7-14(26)8-6-13)17-11-15-3-2-4-18(21(17)32-12)33(15)23(34)16-9-10-30-22(19(16)25)24(27,28)29/h5-10,15,18H,2-4,11H2,1H3/t15-,18+/m1/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM310839
PNG
(US10150766, Example 31)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1cnn(C)c1)N3C(=O)c1cccc(Cl)c1Cl
Show InChI InChI=1S/C22H21Cl2N5O/c1-12-26-20(13-10-25-28(2)11-13)16-9-14-5-3-8-18(21(16)27-12)29(14)22(30)15-6-4-7-17(23)19(15)24/h4,6-7,10-11,14,18H,3,5,8-9H2,1-2H3/t14-,18+/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM310840
PNG
(US10150766, Example 32)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1cnn(C)c1)N3C(=O)c1ccnc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C22H20ClF3N6O/c1-11-29-18(12-9-28-31(2)10-12)15-8-13-4-3-5-16(19(15)30-11)32(13)21(33)14-6-7-27-20(17(14)23)22(24,25)26/h6-7,9-10,13,16H,3-5,8H2,1-2H3/t13-,16+/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM310842
PNG
(US10150766, Example 34)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1cnn(C)c1)N3C(=O)c1cccc(c1F)C(F)(F)F
Show InChI InChI=1S/C23H21F4N5O/c1-12-29-20(13-10-28-31(2)11-13)16-9-14-5-3-8-18(21(16)30-12)32(14)22(33)15-6-4-7-17(19(15)24)23(25,26)27/h4,6-7,10-11,14,18H,3,5,8-9H2,1-2H3/t14-,18+/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM310845
PNG
(US10150766, Example 38)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1cnn(C)c1)N3C(=O)c1ccc(Cl)cc1F
Show InChI InChI=1S/C22H21ClFN5O/c1-12-26-20(13-10-25-28(2)11-13)17-9-15-4-3-5-19(21(17)27-12)29(15)22(30)16-7-6-14(23)8-18(16)24/h6-8,10-11,15,19H,3-5,9H2,1-2H3/t15-,19+/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM310818
PNG
(US10150766, Example 9)
Show SMILES Cc1nc2[C@@H]3CCC[C@H](Cc2c(n1)-c1ccn[nH]1)N3C(=O)c1ccc(F)cc1Cl
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Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM310838
PNG
(US10150766, Example 30)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1cnn(C)c1)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C23H21ClF3N5O/c1-12-29-20(13-10-28-31(2)11-13)16-9-14-5-3-8-18(21(16)30-12)32(14)22(33)15-6-4-7-17(19(15)24)23(25,26)27/h4,6-7,10-11,14,18H,3,5,8-9H2,1-2H3/t14-,18+/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM310843
PNG
(US10150766, Example 35)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1cnn(C)c1)N3C(=O)c1ccc(Cl)c(F)c1Cl
Show InChI InChI=1S/C22H20Cl2FN5O/c1-11-27-20(12-9-26-29(2)10-12)15-8-13-4-3-5-17(21(15)28-11)30(13)22(31)14-6-7-16(23)19(25)18(14)24/h6-7,9-10,13,17H,3-5,8H2,1-2H3/t13-,17+/m0/s1
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US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM310841
PNG
(US10150766, Example 33)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1cnn(C)c1)N3C(=O)c1ccc(F)c(Cl)c1Cl
Show InChI InChI=1S/C22H20Cl2FN5O/c1-11-27-20(12-9-26-29(2)10-12)15-8-13-4-3-5-17(21(15)28-11)30(13)22(31)14-6-7-16(25)19(24)18(14)23/h6-7,9-10,13,17H,3-5,8H2,1-2H3/t13-,17+/m0/s1
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US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM310844
PNG
(US10150766, Example 37)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1cnn(C)c1)N3C(=O)c1ccnc(c1F)C(F)(F)F
Show InChI InChI=1S/C22H20F4N6O/c1-11-29-18(12-9-28-31(2)10-12)15-8-13-4-3-5-16(19(15)30-11)32(13)21(33)14-6-7-27-20(17(14)23)22(24,25)26/h6-7,9-10,13,16H,3-5,8H2,1-2H3/t13-,16+/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM310830
PNG
(US10150766, Example 22)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1ccn[nH]1)N3C(=O)c1ccc(F)cc1Cl
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UniProtKB/SwissProt

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n/an/a>1.00E+4n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM310821
PNG
(US10150766, Example 12)
Show SMILES Cc1nc2[C@@H]3CCC[C@H](Cc2c(n1)-c1ccn[nH]1)N3C(=O)c1ccc(Cl)cc1F
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UniProtKB/SwissProt

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n/an/a>1.00E+4n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM310814
PNG
(US10150766, Example 5)
Show SMILES Cc1nc2[C@@H]3CCC[C@H](Cc2c(n1)-c1ccn[nH]1)N3C(=O)c1ccc(Cl)cc1Cl
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UniProtKB/SwissProt

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US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM310828
PNG
(US10150766, Example 20)
Show SMILES Cc1nc2[C@H]3CCC[C@@H](Cc2c(n1)-c1ccn[nH]1)N3C(=O)c1ccc(Cl)cc1Cl
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n/an/a 1.10E+4n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM310823
PNG
(US10150766, Example 15)
Show SMILES Cc1nc2[C@@H]3CCC[C@H](Cc2c(n1)-c1ccc(F)cc1)N3C(=O)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C24H20Cl2FN3O/c1-13-28-22(14-5-8-16(27)9-6-14)19-12-17-3-2-4-21(23(19)29-13)30(17)24(31)18-10-7-15(25)11-20(18)26/h5-11,17,21H,2-4,12H2,1H3/t17-,21+/m1/s1
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n/an/a 3.60E+4n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10150766 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%