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Patent code US10150767

Compile Data Set for Download or QSAR
Found 46 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM310899
PNG
(4-[4-(1-hydroxy-1-methyl-ethyl)phenyl]-6-methyl-1H...)
Show SMILES Cn1cc(-c2ccc(cc2)C(C)(C)O)c2cc[nH]c2c1=O
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US Patent
n/an/a 21n/an/an/an/an/an/a



Genentech, Inc.; Constellation Pharmaceuticals Inc.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10150767 (2018)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM310892
PNG
(N-(2-methoxyethyl)-4-(6-methyl-7-oxo-1H-pyrrolo[2,...)
Show SMILES COCCNC(=O)c1ccc(cc1)-c1cn(C)c(=O)c2[nH]ccc12
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US Patent
n/an/a 24n/an/an/an/an/an/a



Genentech, Inc.; Constellation Pharmaceuticals Inc.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10150767 (2018)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM310896
PNG
(7-(6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl)-1...)
Show SMILES Cn1cc(-c2ccc3NC(=O)CCNc3c2)c2cc[nH]c2c1=O
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US Patent
n/an/a 25n/an/an/an/an/an/a



Genentech, Inc.; Constellation Pharmaceuticals Inc.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10150767 (2018)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM310895
PNG
(3-methyl-7-(6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridi...)
Show SMILES CC1CNc2cc(ccc2NC1=O)-c1cn(C)c(=O)c2[nH]ccc12
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US Patent
n/an/a 31n/an/an/an/an/an/a



Genentech, Inc.; Constellation Pharmaceuticals Inc.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10150767 (2018)

More data for this
Ligand-Target Pair
CECR2 (aa 424-538)


(Homo sapiens (human))
BDBM310905
PNG
(2-methyl-7-(6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridi...)
Show SMILES CC1Oc2cc(ccc2NC1=O)-c1cn(C)c(=O)c2[nH]ccc12
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US Patent
n/an/a 36n/an/an/an/an/an/a



Genentech, Inc.; Constellation Pharmaceuticals Inc.

US Patent


Assay Description
His/Flag epitope tagged CECR2424-538 was cloned, expressed, and purified to homogeneity. CECR2 binding and inhibition was assessed by monitoring the ...


US Patent US10150767 (2018)

More data for this
Ligand-Target Pair
BRD4 BD1 (aa 42-168)


(Homo sapiens (human))
BDBM310889
PNG
(4-(6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl)-N...)
Show SMILES Cn1cc(-c2ccc(cc2)C(=O)Nc2cccnc2)c2cc[nH]c2c1=O
PDB

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n/an/a 51n/an/an/an/an/an/a



Genentech, Inc.; Constellation Pharmaceuticals Inc.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...


US Patent US10150767 (2018)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM310898
PNG
(N,N-dimethyl-3-(6-methyl-7-oxo-1H-pyrrolo[2,3-c]py...)
Show SMILES CN(C)C(=O)c1cccc(c1)-c1cn(C)c(=O)c2[nH]ccc12
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n/an/a 53n/an/an/an/an/an/a



Genentech, Inc.; Constellation Pharmaceuticals Inc.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10150767 (2018)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM310902
PNG
(6-methyl-4-[4-(1-methyl-4-piperidyl)phenyl]-1H-pyr...)
Show SMILES CN1CCC(CC1)c1ccc(cc1)-c1cn(C)c(=O)c2[nH]ccc12
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US Patent
n/an/a 53n/an/an/an/an/an/a



Genentech, Inc.; Constellation Pharmaceuticals Inc.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10150767 (2018)

More data for this
Ligand-Target Pair
CECR2 (aa 424-538)


(Homo sapiens (human))
BDBM310911
PNG
(6-methyl-4-(2-methyl-3,4-dihydro-1H-isoquinolin-6-...)
Show SMILES Cn1cc(-c2ccc3CNCCc3c2)c2cc[nH]c2c1=O
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n/an/a 54n/an/an/an/an/an/a



Genentech, Inc.; Constellation Pharmaceuticals Inc.

US Patent


Assay Description
His/Flag epitope tagged CECR2424-538 was cloned, expressed, and purified to homogeneity. CECR2 binding and inhibition was assessed by monitoring the ...


US Patent US10150767 (2018)

More data for this
Ligand-Target Pair
BRD4 BD1 (aa 42-168)


(Homo sapiens (human))
BDBM310880
PNG
(7-(6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl)-4...)
Show SMILES Cn1cc(-c2ccc3NC(=O)CC(Nc3c2)c2cccs2)c2cc[nH]c2c1=O
PDB

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US Patent
n/an/a 58n/an/an/an/an/an/a



Genentech, Inc.; Constellation Pharmaceuticals Inc.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...


US Patent US10150767 (2018)

More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (human))
BDBM310915
PNG
(N-benzyl-4-(6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridi...)
Show SMILES Cn1cc(-c2cccc(c2)C(=O)NCc2ccccc2)c2cc[nH]c2c1=O
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n/an/a 63n/an/an/an/an/an/a



Genentech, Inc.; Constellation Pharmaceuticals Inc.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10150767 (2018)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM310903
PNG
(6-methyl-4-[4-[(1-methyl-4-piperidyl)methyl]phenyl...)
Show SMILES CN1CCC(Cc2ccc(cc2)-c2cn(C)c(=O)c3[nH]ccc23)CC1
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n/an/a 64n/an/an/an/an/an/a



Genentech, Inc.; Constellation Pharmaceuticals Inc.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10150767 (2018)

More data for this
Ligand-Target Pair
CECR2 (aa 424-538)


(Homo sapiens (human))
BDBM310910
PNG
(4-(6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl)-N...)
Show SMILES Cn1cc(-c2ccc(cc2)C(=O)Nc2ccccc2)c2cc[nH]c2c1=O
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n/an/a 75n/an/an/an/an/an/a



Genentech, Inc.; Constellation Pharmaceuticals Inc.

US Patent


Assay Description
His/Flag epitope tagged CECR2424-538 was cloned, expressed, and purified to homogeneity. CECR2 binding and inhibition was assessed by monitoring the ...


US Patent US10150767 (2018)

More data for this
Ligand-Target Pair
BRD4 BD1 (aa 42-168)


(Homo sapiens (human))
BDBM310879
PNG
(2-(6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl)-5...)
Show SMILES Cn1cc(C2CC3C=CNN3C3C(CCCC3=O)N2)c2cc[nH]c2c1=O
PDB

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US Patent
n/an/a 81n/an/an/an/an/an/a



Genentech, Inc.; Constellation Pharmaceuticals Inc.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...


US Patent US10150767 (2018)

More data for this
Ligand-Target Pair
BRD4 BD1 (aa 42-168)


(Homo sapiens (human))
BDBM310884
PNG
(4-[4-(3-fluoroazetidine-1-carbonyl)phenyl]-6-methy...)
Show SMILES Cn1cc(-c2ccc(cc2)C(=O)N2CC(F)C2)c2cc[nH]c2c1=O
PDB

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US Patent
n/an/a 84n/an/an/an/an/an/a



Genentech, Inc.; Constellation Pharmaceuticals Inc.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...


US Patent US10150767 (2018)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM310894
PNG
(US10150767, Example 6 | tert-butyl N-[4-(6-methyl-...)
Show SMILES CC(C)(C)OC(=O)Nc1ccc(cc1)-c1c[nH]c(=O)c2[nH]ccc12
Show InChI InChI=1S/C18H17N3O3/c1-18(2,3)24-17(23)21-12-6-4-11(5-7-12)14-10-20-16(22)15-13(14)8-9-19-15/h4-10H,1-3H3,(H,21,23)
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n/an/a 85n/an/an/an/an/an/a



Genentech, Inc.; Constellation Pharmaceuticals Inc.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10150767 (2018)

More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (human))
BDBM310913
PNG
(N-methyl-3-(6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridi...)
Show SMILES CNC(=O)c1cccc(c1)-c1cn(C)c(=O)c2[nH]ccc12
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US Patent
n/an/a 96n/an/an/an/an/an/a



Genentech, Inc.; Constellation Pharmaceuticals Inc.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10150767 (2018)

More data for this
Ligand-Target Pair
BRD4 BD1 (aa 42-168)


(Homo sapiens (human))
BDBM310874
PNG
(US10150767, Example 4 | tert-butyl 6-(6-methyl-7-o...)
Show SMILES Cn1cc(-c2ccc3N(CCCc3c2)C(=O)OC(C)(C)C)c2cc[nH]c2c1=O
PDB

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US Patent
n/an/a 110n/an/an/an/an/an/a



Genentech, Inc.; Constellation Pharmaceuticals Inc.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...


US Patent US10150767 (2018)

More data for this
Ligand-Target Pair
BRD4 BD1 (aa 42-168)


(Homo sapiens (human))
BDBM310876
PNG
(3-methyl-6-(6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridi...)
Show SMILES CC1Nc2cc(ccc2NC1=O)-c1cn(C)c(=O)c2[nH]ccc12
PDB

GoogleScholar
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PC sid
UniChem
US Patent
n/an/a 110n/an/an/an/an/an/a



Genentech, Inc.; Constellation Pharmaceuticals Inc.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...


US Patent US10150767 (2018)

More data for this
Ligand-Target Pair
BRD4 BD1 (aa 42-168)


(Homo sapiens (human))
BDBM310878
PNG
(3-isopropyl-6-(6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyr...)
Show SMILES CC(C)C1Nc2cc(ccc2NC1=O)-c1cn(C)c(=O)c2[nH]ccc12
PDB

GoogleScholar
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PC sid
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US Patent
n/an/a 110n/an/an/an/an/an/a



Genentech, Inc.; Constellation Pharmaceuticals Inc.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...


US Patent US10150767 (2018)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM310901
PNG
(6-cyclopropyl-4-(4-(2-hydroxypropan-2-yl)phenyl)-1...)
Show SMILES CC(C)(O)c1ccc(cc1)-c1cn(C2CC2)c(=O)c2[nH]ccc12
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PC sid
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US Patent
n/an/a 110n/an/an/an/an/an/a



Genentech, Inc.; Constellation Pharmaceuticals Inc.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10150767 (2018)

More data for this
Ligand-Target Pair
CECR2 (aa 424-538)


(Homo sapiens (human))
BDBM310909
PNG
(4-[4-(3,3-difluoroazetidine-1-carbonyl)phenyl]-6-m...)
Show SMILES Cn1cc(-c2ccc(cc2)C(=O)N2CC(F)(F)C2)c2cc[nH]c2c1=O
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PC sid
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US Patent
n/an/a 130n/an/an/an/an/an/a



Genentech, Inc.; Constellation Pharmaceuticals Inc.

US Patent


Assay Description
His/Flag epitope tagged CECR2424-538 was cloned, expressed, and purified to homogeneity. CECR2 binding and inhibition was assessed by monitoring the ...


US Patent US10150767 (2018)

More data for this
Ligand-Target Pair
CECR2 (aa 424-538)


(Homo sapiens (human))
BDBM310912
PNG
(3-(2,6-dimethyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-y...)
Show SMILES CN(C)C(=O)c1cccc(c1)-c1cn(C)c(=O)c2[nH]c(C)cc12
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US Patent
n/an/a 130n/an/an/an/an/an/a



Genentech, Inc.; Constellation Pharmaceuticals Inc.

US Patent


Assay Description
His/Flag epitope tagged CECR2424-538 was cloned, expressed, and purified to homogeneity. CECR2 binding and inhibition was assessed by monitoring the ...


US Patent US10150767 (2018)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM310893
PNG
(US10150767, Example 5 | tert-butyl 7-(6-methyl-7-o...)
Show SMILES CC(C)(C)OC(=O)N1CCCc2ccc(cc12)-c1c[nH]c(=O)c2[nH]ccc12
Show InChI InChI=1S/C21H21N3O3/c1-21(2,3)27-20(26)24-10-4-5-13-6-7-14(11-17(13)24)16-12-23-19(25)18-15(16)8-9-22-18/h6-9,11-12H,4-5,10H2,1-3H3
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n/an/a 130n/an/an/an/an/an/a



Genentech, Inc.; Constellation Pharmaceuticals Inc.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10150767 (2018)

More data for this
Ligand-Target Pair
BRD4 BD1 (aa 42-168)


(Homo sapiens (human))
BDBM310882
PNG
(3-(6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl)be...)
Show SMILES Cn1cc(-c2cccc(c2)C#N)c2cc[nH]c2c1=O
PDB

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PC sid
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US Patent
n/an/a 150n/an/an/an/an/an/a



Genentech, Inc.; Constellation Pharmaceuticals Inc.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...


US Patent US10150767 (2018)

More data for this
Ligand-Target Pair
CECR2 (aa 424-538)


(Homo sapiens (human))
BDBM310904
PNG
(3-methoxy-N-[4-(6-methyl-7-oxo-1H-pyrrolo[2,3-c]py...)
Show SMILES COCCC(=O)Nc1ccc(cc1)-c1cn(C)c(=O)c2[nH]ccc12
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US Patent
n/an/a 170n/an/an/an/an/an/a



Genentech, Inc.; Constellation Pharmaceuticals Inc.

US Patent


Assay Description
His/Flag epitope tagged CECR2424-538 was cloned, expressed, and purified to homogeneity. CECR2 binding and inhibition was assessed by monitoring the ...


US Patent US10150767 (2018)

More data for this
Ligand-Target Pair
BRD4 BD1 (aa 42-168)


(Homo sapiens (human))
BDBM310886
PNG
(6-methyl-4-[4-(4-methylpiperidine-1-carbonyl)pheny...)
Show SMILES CN1CCN(CC1)C(=O)c1ccc(cc1)-c1cn(C)c(=O)c2[nH]ccc12
PDB

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n/an/a 170n/an/an/an/an/an/a



Genentech, Inc.; Constellation Pharmaceuticals Inc.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...


US Patent US10150767 (2018)

More data for this
Ligand-Target Pair
BRD4 BD1 (aa 42-168)


(Homo sapiens (human))
BDBM310877
PNG
(4-methyl-7-(6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridi...)
Show SMILES CC1CC(=O)Nc2ccc(cc2N1)-c1cn(C)c(=O)c2[nH]ccc12
PDB

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PC sid
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US Patent
n/an/a 170n/an/an/an/an/an/a



Genentech, Inc.; Constellation Pharmaceuticals Inc.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...


US Patent US10150767 (2018)

More data for this
Ligand-Target Pair
BRD4 BD1 (aa 42-168)


(Homo sapiens (human))
BDBM310881
PNG
(3-(6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl)be...)
Show SMILES Cn1cc(-c2cccc(c2)C(N)=O)c2cc[nH]c2c1=O
PDB

GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/a 180n/an/an/an/an/an/a



Genentech, Inc.; Constellation Pharmaceuticals Inc.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...


US Patent US10150767 (2018)

More data for this
Ligand-Target Pair
BRD4 BD1 (aa 42-168)


(Homo sapiens (human))
BDBM310891
PNG
(N-(cyanomethyl)-N-methyl-4-(6-methyl-7-oxo-1H-pyrr...)
Show SMILES CN(CC#N)C(=O)c1ccc(cc1)-c1cn(C)c(=O)c2[nH]ccc12
PDB

GoogleScholar
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PC sid
UniChem
US Patent
n/an/a 200n/an/an/an/an/an/a



Genentech, Inc.; Constellation Pharmaceuticals Inc.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...


US Patent US10150767 (2018)

More data for this
Ligand-Target Pair
BRD4 BD1 (aa 42-168)


(Homo sapiens (human))
BDBM310873
PNG
(6-methyl-4-(2-oxoindolin-5-yl)-1H-pyrrolo[2,3-c]py...)
Show SMILES Cn1cc(-c2ccc3NC(=O)Cc3c2)c2cc[nH]c2c1=O
PDB

GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/a 210n/an/an/an/an/an/a



Genentech, Inc.; Constellation Pharmaceuticals Inc.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...


US Patent US10150767 (2018)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM310897
PNG
(N,N-dimethyl-3-(7-oxo-6-propyl-1H-pyrrolo[2,3-c]py...)
Show SMILES CCCn1cc(-c2cccc(c2)C(=O)N(C)C)c2cc[nH]c2c1=O
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PC sid
UniChem
US Patent
n/an/a 238n/an/an/an/an/an/a



Genentech, Inc.; Constellation Pharmaceuticals Inc.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10150767 (2018)

More data for this
Ligand-Target Pair
CECR2 (aa 424-538)


(Homo sapiens (human))
BDBM310908
PNG
(6-methyl-4-(4-(4-methyl-3-oxopiperazine-1-carbonyl...)
Show SMILES CN1CCN(CC1=O)C(=O)c1ccc(cc1)-c1cn(C)c(=O)c2[nH]ccc12
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n/an/a 240n/an/an/an/an/an/a



Genentech, Inc.; Constellation Pharmaceuticals Inc.

US Patent


Assay Description
His/Flag epitope tagged CECR2424-538 was cloned, expressed, and purified to homogeneity. CECR2 binding and inhibition was assessed by monitoring the ...


US Patent US10150767 (2018)

More data for this
Ligand-Target Pair
BRD4 BD1 (aa 42-168)


(Homo sapiens (human))
BDBM310886
PNG
(6-methyl-4-[4-(4-methylpiperidine-1-carbonyl)pheny...)
Show SMILES CN1CCN(CC1)C(=O)c1ccc(cc1)-c1cn(C)c(=O)c2[nH]ccc12
PDB

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n/an/a 260n/an/an/an/an/an/a



Genentech, Inc.; Constellation Pharmaceuticals Inc.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...


US Patent US10150767 (2018)

More data for this
Ligand-Target Pair
BRD4 BD1 (aa 42-168)


(Homo sapiens (human))
BDBM310885
PNG
(6-methyl-4-[4-(pyrrolidine-1-carbonyl)phenyl]-1H-p...)
Show SMILES Cn1cc(-c2ccc(cc2)C(=O)N2CCCC2)c2cc[nH]c2c1=O
PDB

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US Patent
n/an/a 280n/an/an/an/an/an/a



Genentech, Inc.; Constellation Pharmaceuticals Inc.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...


US Patent US10150767 (2018)

More data for this
Ligand-Target Pair
BRD4 BD1 (aa 42-168)


(Homo sapiens (human))
BDBM310875
PNG
(8-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyr...)
Show SMILES Cn1cc(-c2ccc3NC(=O)C4CCC(=O)N4c3c2)c2cc[nH]c2c1=O
PDB

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US Patent
n/an/a 310n/an/an/an/an/an/a



Genentech, Inc.; Constellation Pharmaceuticals Inc.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...


US Patent US10150767 (2018)

More data for this
Ligand-Target Pair
BRD4 BD1 (aa 42-168)


(Homo sapiens (human))
BDBM310887
PNG
(4-[4-(4-acetylpiperazine-1-carbonyl)phenyl]-6-meth...)
Show SMILES Cn1cc(-c2ccc(cc2)C(=O)N2CCN(CC(N)=O)CC2)c2cc[nH]c2c1=O
PDB

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US Patent
n/an/a 320n/an/an/an/an/an/a



Genentech, Inc.; Constellation Pharmaceuticals Inc.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...


US Patent US10150767 (2018)

More data for this
Ligand-Target Pair
BRD4 BD1 (aa 42-168)


(Homo sapiens (human))
BDBM310890
PNG
(N-methyl-4-(6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridi...)
Show SMILES CN(C(=O)c1ccc(cc1)-c1cn(C)c(=O)c2[nH]ccc12)c1ccccc1
PDB

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n/an/a 340n/an/an/an/an/an/a



Genentech, Inc.; Constellation Pharmaceuticals Inc.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...


US Patent US10150767 (2018)

More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (human))
BDBM310914
PNG
(6-methyl-4-[4-(morpholine-4-carbonyl)phenyl]-1H-py...)
Show SMILES Cn1cc(-c2ccc(cc2)C(=O)N2CCOCC2)c2cc[nH]c2c1=O
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n/an/a 350n/an/an/an/an/an/a



Genentech, Inc.; Constellation Pharmaceuticals Inc.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10150767 (2018)

More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (human))
BDBM310917
PNG
(6-methyl-4-[3-[(1-methyl-4-piperidyl)methyl]phenyl...)
Show SMILES CN1CCC(Cc2cccc(c2)-c2cn(C)c(=O)c3[nH]ccc23)CC1
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n/an/a 440n/an/an/an/an/an/a



Genentech, Inc.; Constellation Pharmaceuticals Inc.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10150767 (2018)

More data for this
Ligand-Target Pair
BRD4 BD1 (aa 42-168)


(Homo sapiens (human))
BDBM310872
PNG
(6-methyl-4-phenyl-1H-pyrrolo[2,3-c]pyridin-7(6H)-o...)
Show SMILES Cn1cc(-c2ccccc2)c2cc[nH]c2c1=O
PDB

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n/an/a 540n/an/an/an/an/an/a



Genentech, Inc.; Constellation Pharmaceuticals Inc.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...


US Patent US10150767 (2018)

More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (human))
BDBM310916
PNG
(6-methyl-4-[3-(1-methyl-4-piperidyl)phenyl]-1H-pyr...)
Show SMILES CN1CCC(CC1)c1cccc(c1)-c1cn(C)c(=O)c2[nH]ccc12
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n/an/a 680n/an/an/an/an/an/a



Genentech, Inc.; Constellation Pharmaceuticals Inc.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10150767 (2018)

More data for this
Ligand-Target Pair
BRD4 BD1 (aa 42-168)


(Homo sapiens (human))
BDBM310883
PNG
(4-[4-(hydroxymethyl)phenyl]-6-methyl-1H-pyrrolo[2,...)
Show SMILES Cn1cc(-c2ccc(CO)cc2)c2cc[nH]c2c1=O
PDB

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n/an/a 710n/an/an/an/an/an/a



Genentech, Inc.; Constellation Pharmaceuticals Inc.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...


US Patent US10150767 (2018)

More data for this
Ligand-Target Pair
CECR2 (aa 424-538)


(Homo sapiens (human))
BDBM310906
PNG
(N,N-dimethyl-4-(6-methyl-7-oxo-1H-pyrrolo[2,3-c]py...)
Show SMILES CN(C)C(=O)c1ccc(cc1)-c1cn(C)c(=O)c2[nH]ccc12
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n/an/a 730n/an/an/an/an/an/a



Genentech, Inc.; Constellation Pharmaceuticals Inc.

US Patent


Assay Description
His/Flag epitope tagged CECR2424-538 was cloned, expressed, and purified to homogeneity. CECR2 binding and inhibition was assessed by monitoring the ...


US Patent US10150767 (2018)

More data for this
Ligand-Target Pair
CECR2 (aa 424-538)


(Homo sapiens (human))
BDBM310907
PNG
(3-(6-ethyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl)-N,...)
Show SMILES CCn1cc(-c2cccc(c2)C(=O)N(C)C)c2cc[nH]c2c1=O
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n/an/a 1.30E+3n/an/an/an/an/an/a



Genentech, Inc.; Constellation Pharmaceuticals Inc.

US Patent


Assay Description
His/Flag epitope tagged CECR2424-538 was cloned, expressed, and purified to homogeneity. CECR2 binding and inhibition was assessed by monitoring the ...


US Patent US10150767 (2018)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM310900
PNG
(4-[4-(1-hydroxy-1-methyl-ethyl)phenyl]-6-isopropyl...)
Show SMILES CC(C)n1cc(-c2ccc(cc2)C(C)(C)O)c2cc[nH]c2c1=O
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n/an/a 4.10E+3n/an/an/an/an/an/a



Genentech, Inc.; Constellation Pharmaceuticals Inc.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10150767 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%