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Patent code US10155727

Compile Data Set for Download or QSAR

Found 217 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glutamate receptor ionotropic, NMDA 2B


(Rattus norvegicus (Rat))
BDBM50201022
PNG
(CHEMBL3897632 | US10155727, Example 6)
Show SMILES FC(F)Oc1cc(ccc1Cl)-c1cnn(Cc2cc[nH]n2)c1
Show InChI InChI=1S/C14H11ClF2N4O/c15-12-2-1-9(5-13(12)22-14(16)17)10-6-19-21(7-10)8-11-3-4-18-20-11/h1-7,14H,8H2,(H,18,20)
PDB

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n/an/a 5.21n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
After thawing on the day of the assay, a 5 ml membrane aliquot was centrifuged at 48000 g for 30 min at 4 C. The pellet was resuspended in 5 ml of 5...


US Patent US10155727 (2018)

More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50201022
PNG
(CHEMBL3897632 | US10155727, Example 6)
Show SMILES FC(F)Oc1cc(ccc1Cl)-c1cnn(Cc2cc[nH]n2)c1
Show InChI InChI=1S/C14H11ClF2N4O/c15-12-2-1-9(5-13(12)22-14(16)17)10-6-19-21(7-10)8-11-3-4-18-20-11/h1-7,14H,8H2,(H,18,20)
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n/an/a 5.21n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
After thawing on the day of the assay, the membrane suspension was diluted further with 20 mM HEPES/0.1 mM KCl/pH 7.2.The incubation mixture of 200 &...


US Patent US10155727 (2018)

More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50201028
PNG
(CHEMBL3954438 | US10155727, Example 18)
Show SMILES FC(F)Oc1cc(ccc1F)-c1cnn(Cc2cc[nH]n2)c1
Show InChI InChI=1S/C14H11F3N4O/c15-12-2-1-9(5-13(12)22-14(16)17)10-6-19-21(7-10)8-11-3-4-18-20-11/h1-7,14H,8H2,(H,18,20)
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n/an/a 8.01n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
After thawing on the day of the assay, the membrane suspension was diluted further with 20 mM HEPES/0.1 mM KCl/pH 7.2.The incubation mixture of 200 &...


US Patent US10155727 (2018)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Rattus norvegicus (Rat))
BDBM50201028
PNG
(CHEMBL3954438 | US10155727, Example 18)
Show SMILES FC(F)Oc1cc(ccc1F)-c1cnn(Cc2cc[nH]n2)c1
Show InChI InChI=1S/C14H11F3N4O/c15-12-2-1-9(5-13(12)22-14(16)17)10-6-19-21(7-10)8-11-3-4-18-20-11/h1-7,14H,8H2,(H,18,20)
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n/an/a 8.01n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
After thawing on the day of the assay, a 5 ml membrane aliquot was centrifuged at 48000 g for 30 min at 4 C. The pellet was resuspended in 5 ml of 5...


US Patent US10155727 (2018)

More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50201023
PNG
(CHEMBL3927856 | US10155727, Example 7)
Show SMILES FC(F)Oc1cc(ccc1Cl)-c1cnn(Cc2cn[nH]c2)c1
Show InChI InChI=1S/C14H11ClF2N4O/c15-12-2-1-10(3-13(12)22-14(16)17)11-6-20-21(8-11)7-9-4-18-19-5-9/h1-6,8,14H,7H2,(H,18,19)
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n/an/a 8.23n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
After thawing on the day of the assay, the membrane suspension was diluted further with 20 mM HEPES/0.1 mM KCl/pH 7.2.The incubation mixture of 200 &...


US Patent US10155727 (2018)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Rattus norvegicus (Rat))
BDBM50201023
PNG
(CHEMBL3927856 | US10155727, Example 7)
Show SMILES FC(F)Oc1cc(ccc1Cl)-c1cnn(Cc2cn[nH]c2)c1
Show InChI InChI=1S/C14H11ClF2N4O/c15-12-2-1-10(3-13(12)22-14(16)17)11-6-20-21(8-11)7-9-4-18-19-5-9/h1-6,8,14H,7H2,(H,18,19)
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n/an/a 8.23n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
After thawing on the day of the assay, a 5 ml membrane aliquot was centrifuged at 48000 g for 30 min at 4 C. The pellet was resuspended in 5 ml of 5...


US Patent US10155727 (2018)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Rattus norvegicus (Rat))
BDBM310990
PNG
(US10155727, Example 44)
Show SMILES CC(F)(F)c1cc(ccc1F)-c1cnn(Cc2cc[nH]n2)c1
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n/an/a 17.1n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
After thawing on the day of the assay, a 5 ml membrane aliquot was centrifuged at 48000 g for 30 min at 4 C. The pellet was resuspended in 5 ml of 5...


US Patent US10155727 (2018)

More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM310990
PNG
(US10155727, Example 44)
Show SMILES CC(F)(F)c1cc(ccc1F)-c1cnn(Cc2cc[nH]n2)c1
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n/an/a 17.1n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
After thawing on the day of the assay, the membrane suspension was diluted further with 20 mM HEPES/0.1 mM KCl/pH 7.2.The incubation mixture of 200 &...


US Patent US10155727 (2018)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Rattus norvegicus (Rat))
BDBM310981
PNG
(US10155727, Example 35)
Show SMILES FC(F)c1cc(ccc1F)-c1cnn(Cc2cc[nH]n2)c1
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n/an/a 17.6n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
After thawing on the day of the assay, a 5 ml membrane aliquot was centrifuged at 48000 g for 30 min at 4 C. The pellet was resuspended in 5 ml of 5...


US Patent US10155727 (2018)

More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM310981
PNG
(US10155727, Example 35)
Show SMILES FC(F)c1cc(ccc1F)-c1cnn(Cc2cc[nH]n2)c1
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n/an/a 17.6n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
After thawing on the day of the assay, the membrane suspension was diluted further with 20 mM HEPES/0.1 mM KCl/pH 7.2.The incubation mixture of 200 &...


US Patent US10155727 (2018)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Rattus norvegicus (Rat))
BDBM310959
PNG
(US10155727, Example 13)
Show SMILES Cc1cc(Cn2cc(cn2)-c2ccc(Cl)c(OC(F)F)c2)[nH]n1
PDB

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n/an/a 22.1n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
After thawing on the day of the assay, a 5 ml membrane aliquot was centrifuged at 48000 g for 30 min at 4 C. The pellet was resuspended in 5 ml of 5...


US Patent US10155727 (2018)

More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM310959
PNG
(US10155727, Example 13)
Show SMILES Cc1cc(Cn2cc(cn2)-c2ccc(Cl)c(OC(F)F)c2)[nH]n1
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n/an/a 22.1n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
After thawing on the day of the assay, the membrane suspension was diluted further with 20 mM HEPES/0.1 mM KCl/pH 7.2.The incubation mixture of 200 &...


US Patent US10155727 (2018)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Rattus norvegicus (Rat))
BDBM310966
PNG
(US10155727, Example 20)
Show SMILES CCc1[nH]ncc1Cn1cc(cn1)-c1ccc(F)c(OC(F)F)c1
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n/an/a 22.2n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
After thawing on the day of the assay, a 5 ml membrane aliquot was centrifuged at 48000 g for 30 min at 4 C. The pellet was resuspended in 5 ml of 5...


US Patent US10155727 (2018)

More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM310966
PNG
(US10155727, Example 20)
Show SMILES CCc1[nH]ncc1Cn1cc(cn1)-c1ccc(F)c(OC(F)F)c1
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n/an/a 22.2n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
After thawing on the day of the assay, the membrane suspension was diluted further with 20 mM HEPES/0.1 mM KCl/pH 7.2.The incubation mixture of 200 &...


US Patent US10155727 (2018)

More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM311032
PNG
(US10155727, Example 93)
Show SMILES CC(F)(F)c1cccc(c1)-c1cnn(Cc2cc[nH]n2)c1
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n/an/a 25.2n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
After thawing on the day of the assay, the membrane suspension was diluted further with 20 mM HEPES/0.1 mM KCl/pH 7.2.The incubation mixture of 200 &...


US Patent US10155727 (2018)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Rattus norvegicus (Rat))
BDBM311032
PNG
(US10155727, Example 93)
Show SMILES CC(F)(F)c1cccc(c1)-c1cnn(Cc2cc[nH]n2)c1
PDB

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n/an/a 25.2n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
After thawing on the day of the assay, a 5 ml membrane aliquot was centrifuged at 48000 g for 30 min at 4 C. The pellet was resuspended in 5 ml of 5...


US Patent US10155727 (2018)

More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50201025
PNG
(CHEMBL3975087 | US10155727, Example 26)
Show SMILES FC(F)c1cc(ccc1Cl)-c1cnn(Cc2cc[nH]n2)c1
Show InChI InChI=1S/C14H11ClF2N4/c15-13-2-1-9(5-12(13)14(16)17)10-6-19-21(7-10)8-11-3-4-18-20-11/h1-7,14H,8H2,(H,18,20)
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n/an/a 30.1n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
After thawing on the day of the assay, the membrane suspension was diluted further with 20 mM HEPES/0.1 mM KCl/pH 7.2.The incubation mixture of 200 &...


US Patent US10155727 (2018)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Rattus norvegicus (Rat))
BDBM50201025
PNG
(CHEMBL3975087 | US10155727, Example 26)
Show SMILES FC(F)c1cc(ccc1Cl)-c1cnn(Cc2cc[nH]n2)c1
Show InChI InChI=1S/C14H11ClF2N4/c15-13-2-1-9(5-12(13)14(16)17)10-6-19-21(7-10)8-11-3-4-18-20-11/h1-7,14H,8H2,(H,18,20)
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n/an/a 30.1n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
After thawing on the day of the assay, a 5 ml membrane aliquot was centrifuged at 48000 g for 30 min at 4 C. The pellet was resuspended in 5 ml of 5...


US Patent US10155727 (2018)

More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM310962
PNG
(US10155727, Example 16)
Show SMILES Cc1[nH]ncc1Cn1cc(cn1)-c1ccc(Cl)c(OC(F)F)c1
PDB
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n/an/a 41.1n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
After thawing on the day of the assay, the membrane suspension was diluted further with 20 mM HEPES/0.1 mM KCl/pH 7.2.The incubation mixture of 200 &...


US Patent US10155727 (2018)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Rattus norvegicus (Rat))
BDBM310962
PNG
(US10155727, Example 16)
Show SMILES Cc1[nH]ncc1Cn1cc(cn1)-c1ccc(Cl)c(OC(F)F)c1
PDB

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n/an/a 41.1n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
After thawing on the day of the assay, a 5 ml membrane aliquot was centrifuged at 48000 g for 30 min at 4 C. The pellet was resuspended in 5 ml of 5...


US Patent US10155727 (2018)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Rattus norvegicus (Rat))
BDBM311030
PNG
(US10155727, Example 91)
Show SMILES CCc1c[nH]nc1Cn1cc(cn1)-c1ccc(F)c(OC(F)F)c1
PDB

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n/an/a 43.8n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
After thawing on the day of the assay, a 5 ml membrane aliquot was centrifuged at 48000 g for 30 min at 4 C. The pellet was resuspended in 5 ml of 5...


US Patent US10155727 (2018)

More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM311030
PNG
(US10155727, Example 91)
Show SMILES CCc1c[nH]nc1Cn1cc(cn1)-c1ccc(F)c(OC(F)F)c1
PDB
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n/an/a 43.8n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
After thawing on the day of the assay, the membrane suspension was diluted further with 20 mM HEPES/0.1 mM KCl/pH 7.2.The incubation mixture of 200 &...


US Patent US10155727 (2018)

More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM310986
PNG
(US10155727, Example 40)
Show SMILES CCc1cc(Cn2cc(cn2)-c2ccc(F)c(c2)C(F)F)n[nH]1
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n/an/a 47n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
After thawing on the day of the assay, the membrane suspension was diluted further with 20 mM HEPES/0.1 mM KCl/pH 7.2.The incubation mixture of 200 &...


US Patent US10155727 (2018)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Rattus norvegicus (Rat))
BDBM310986
PNG
(US10155727, Example 40)
Show SMILES CCc1cc(Cn2cc(cn2)-c2ccc(F)c(c2)C(F)F)n[nH]1
PDB

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n/an/a 47n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
After thawing on the day of the assay, a 5 ml membrane aliquot was centrifuged at 48000 g for 30 min at 4 C. The pellet was resuspended in 5 ml of 5...


US Patent US10155727 (2018)

More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50201026
PNG
(CHEMBL3983077 | US10155727, Example 17)
Show SMILES CCc1[nH]ncc1Cn1cc(cn1)-c1ccc(Cl)c(OC(F)F)c1
Show InChI InChI=1S/C16H15ClF2N4O/c1-2-14-12(6-20-22-14)9-23-8-11(7-21-23)10-3-4-13(17)15(5-10)24-16(18)19/h3-8,16H,2,9H2,1H3,(H,20,22)
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n/an/a 56n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
After thawing on the day of the assay, the membrane suspension was diluted further with 20 mM HEPES/0.1 mM KCl/pH 7.2.The incubation mixture of 200 &...


US Patent US10155727 (2018)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Rattus norvegicus (Rat))
BDBM50201026
PNG
(CHEMBL3983077 | US10155727, Example 17)
Show SMILES CCc1[nH]ncc1Cn1cc(cn1)-c1ccc(Cl)c(OC(F)F)c1
Show InChI InChI=1S/C16H15ClF2N4O/c1-2-14-12(6-20-22-14)9-23-8-11(7-21-23)10-3-4-13(17)15(5-10)24-16(18)19/h3-8,16H,2,9H2,1H3,(H,20,22)
PDB

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n/an/a 56n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
After thawing on the day of the assay, a 5 ml membrane aliquot was centrifuged at 48000 g for 30 min at 4 C. The pellet was resuspended in 5 ml of 5...


US Patent US10155727 (2018)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Rattus norvegicus (Rat))
BDBM311034
PNG
(US10155727, Example 95)
Show SMILES CCn1cncc1Cn1cc(cn1)-c1ccc(Cl)c(c1)C(F)F
Show InChI InChI=1S/C16H15ClF2N4/c1-2-22-10-20-7-13(22)9-23-8-12(6-21-23)11-3-4-15(17)14(5-11)16(18)19/h3-8,10,16H,2,9H2,1H3
PDB

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n/an/a 63.5n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
After thawing on the day of the assay, a 5 ml membrane aliquot was centrifuged at 48000 g for 30 min at 4 C. The pellet was resuspended in 5 ml of 5...


US Patent US10155727 (2018)

More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM311034
PNG
(US10155727, Example 95)
Show SMILES CCn1cncc1Cn1cc(cn1)-c1ccc(Cl)c(c1)C(F)F
Show InChI InChI=1S/C16H15ClF2N4/c1-2-22-10-20-7-13(22)9-23-8-12(6-21-23)11-3-4-15(17)14(5-11)16(18)19/h3-8,10,16H,2,9H2,1H3
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n/an/a 63.5n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
After thawing on the day of the assay, the membrane suspension was diluted further with 20 mM HEPES/0.1 mM KCl/pH 7.2.The incubation mixture of 200 &...


US Patent US10155727 (2018)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Rattus norvegicus (Rat))
BDBM310948
PNG
(US10155727, Example 1)
Show SMILES Cc1n[nH]c(C)c1CCn1cc(cn1)-c1ccc(Cl)c(OC(F)F)c1
PDB

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n/an/a 65.5n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
After thawing on the day of the assay, a 5 ml membrane aliquot was centrifuged at 48000 g for 30 min at 4 C. The pellet was resuspended in 5 ml of 5...


US Patent US10155727 (2018)

More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM310948
PNG
(US10155727, Example 1)
Show SMILES Cc1n[nH]c(C)c1CCn1cc(cn1)-c1ccc(Cl)c(OC(F)F)c1
PDB
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n/an/a 65.5n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
After thawing on the day of the assay, the membrane suspension was diluted further with 20 mM HEPES/0.1 mM KCl/pH 7.2.The incubation mixture of 200 &...


US Patent US10155727 (2018)

More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM311031
PNG
(US10155727, Example 92)
Show SMILES CCc1c[nH]nc1Cn1cc(cn1)-c1ccc(F)c(c1)C(F)F
PDB
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n/an/a 71.2n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
After thawing on the day of the assay, the membrane suspension was diluted further with 20 mM HEPES/0.1 mM KCl/pH 7.2.The incubation mixture of 200 &...


US Patent US10155727 (2018)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Rattus norvegicus (Rat))
BDBM311031
PNG
(US10155727, Example 92)
Show SMILES CCc1c[nH]nc1Cn1cc(cn1)-c1ccc(F)c(c1)C(F)F
PDB

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n/an/a 71.2n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
After thawing on the day of the assay, a 5 ml membrane aliquot was centrifuged at 48000 g for 30 min at 4 C. The pellet was resuspended in 5 ml of 5...


US Patent US10155727 (2018)

More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM310960
PNG
(US10155727, Example 14)
Show SMILES CCc1cc(Cn2cc(cn2)-c2ccc(Cl)c(OC(F)F)c2)n[nH]1
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n/an/a 76.2n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
After thawing on the day of the assay, the membrane suspension was diluted further with 20 mM HEPES/0.1 mM KCl/pH 7.2.The incubation mixture of 200 &...


US Patent US10155727 (2018)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Rattus norvegicus (Rat))
BDBM310960
PNG
(US10155727, Example 14)
Show SMILES CCc1cc(Cn2cc(cn2)-c2ccc(Cl)c(OC(F)F)c2)n[nH]1
PDB

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n/an/a 76.2n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
After thawing on the day of the assay, a 5 ml membrane aliquot was centrifuged at 48000 g for 30 min at 4 C. The pellet was resuspended in 5 ml of 5...


US Patent US10155727 (2018)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Rattus norvegicus (Rat))
BDBM311035
PNG
(US10155727, Example 96)
Show SMILES CCn1cncc1Cn1cc(cn1)-c1ccc(F)c(C)c1
Show InChI InChI=1S/C16H17FN4/c1-3-20-11-18-8-15(20)10-21-9-14(7-19-21)13-4-5-16(17)12(2)6-13/h4-9,11H,3,10H2,1-2H3
PDB

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n/an/a 77.8n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
After thawing on the day of the assay, a 5 ml membrane aliquot was centrifuged at 48000 g for 30 min at 4 C. The pellet was resuspended in 5 ml of 5...


US Patent US10155727 (2018)

More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM311035
PNG
(US10155727, Example 96)
Show SMILES CCn1cncc1Cn1cc(cn1)-c1ccc(F)c(C)c1
Show InChI InChI=1S/C16H17FN4/c1-3-20-11-18-8-15(20)10-21-9-14(7-19-21)13-4-5-16(17)12(2)6-13/h4-9,11H,3,10H2,1-2H3
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n/an/a 77.8n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
After thawing on the day of the assay, the membrane suspension was diluted further with 20 mM HEPES/0.1 mM KCl/pH 7.2.The incubation mixture of 200 &...


US Patent US10155727 (2018)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Rattus norvegicus (Rat))
BDBM50201021
PNG
(CHEMBL3966599 | US10155727, Example 2)
Show SMILES Cn1ccc(Cn2cc(cn2)-c2ccc(Cl)c(OC(F)F)c2)n1
Show InChI InChI=1S/C15H13ClF2N4O/c1-21-5-4-12(20-21)9-22-8-11(7-19-22)10-2-3-13(16)14(6-10)23-15(17)18/h2-8,15H,9H2,1H3
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n/an/a 78.4n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
After thawing on the day of the assay, a 5 ml membrane aliquot was centrifuged at 48000 g for 30 min at 4 C. The pellet was resuspended in 5 ml of 5...


US Patent US10155727 (2018)

More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50201021
PNG
(CHEMBL3966599 | US10155727, Example 2)
Show SMILES Cn1ccc(Cn2cc(cn2)-c2ccc(Cl)c(OC(F)F)c2)n1
Show InChI InChI=1S/C15H13ClF2N4O/c1-21-5-4-12(20-21)9-22-8-11(7-19-22)10-2-3-13(16)14(6-10)23-15(17)18/h2-8,15H,9H2,1H3
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n/an/a 78.4n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
After thawing on the day of the assay, the membrane suspension was diluted further with 20 mM HEPES/0.1 mM KCl/pH 7.2.The incubation mixture of 200 &...


US Patent US10155727 (2018)

More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM311001
PNG
(US10155727, Example 56)
Show SMILES Cc1cc(ccc1F)-c1cnn(Cc2cc[nH]n2)c1
PDB
MMDB

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n/an/a 78.7n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
After thawing on the day of the assay, the membrane suspension was diluted further with 20 mM HEPES/0.1 mM KCl/pH 7.2.The incubation mixture of 200 &...


US Patent US10155727 (2018)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Rattus norvegicus (Rat))
BDBM311001
PNG
(US10155727, Example 56)
Show SMILES Cc1cc(ccc1F)-c1cnn(Cc2cc[nH]n2)c1
PDB

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n/an/a 78.7n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
After thawing on the day of the assay, a 5 ml membrane aliquot was centrifuged at 48000 g for 30 min at 4 C. The pellet was resuspended in 5 ml of 5...


US Patent US10155727 (2018)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Rattus norvegicus (Rat))
BDBM311015
PNG
(US10155727, Example 72)
Show SMILES FS(F)(F)(F)(F)c1cccc(c1)-c1cnn(Cc2cc[nH]n2)c1
PDB

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n/an/a 95.1n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
After thawing on the day of the assay, a 5 ml membrane aliquot was centrifuged at 48000 g for 30 min at 4 C. The pellet was resuspended in 5 ml of 5...


US Patent US10155727 (2018)

More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM311015
PNG
(US10155727, Example 72)
Show SMILES FS(F)(F)(F)(F)c1cccc(c1)-c1cnn(Cc2cc[nH]n2)c1
PDB
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n/an/a 95.1n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
After thawing on the day of the assay, the membrane suspension was diluted further with 20 mM HEPES/0.1 mM KCl/pH 7.2.The incubation mixture of 200 &...


US Patent US10155727 (2018)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Rattus norvegicus (Rat))
BDBM310985
PNG
(US10155727, Example 39)
Show SMILES Cc1cc(Cn2cc(cn2)-c2ccc(F)c(c2)C(F)F)[nH]n1
PDB

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n/an/a 102n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
After thawing on the day of the assay, a 5 ml membrane aliquot was centrifuged at 48000 g for 30 min at 4 C. The pellet was resuspended in 5 ml of 5...


US Patent US10155727 (2018)

More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM310985
PNG
(US10155727, Example 39)
Show SMILES Cc1cc(Cn2cc(cn2)-c2ccc(F)c(c2)C(F)F)[nH]n1
PDB
MMDB

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n/an/a 102n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
After thawing on the day of the assay, the membrane suspension was diluted further with 20 mM HEPES/0.1 mM KCl/pH 7.2.The incubation mixture of 200 &...


US Patent US10155727 (2018)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Rattus norvegicus (Rat))
BDBM310992
PNG
(US10155727, Example 46)
Show SMILES CCc1[nH]ncc1Cn1cc(cn1)-c1ccc(F)c(c1)C(C)(F)F
PDB

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n/an/a 106n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
After thawing on the day of the assay, a 5 ml membrane aliquot was centrifuged at 48000 g for 30 min at 4 C. The pellet was resuspended in 5 ml of 5...


US Patent US10155727 (2018)

More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM310992
PNG
(US10155727, Example 46)
Show SMILES CCc1[nH]ncc1Cn1cc(cn1)-c1ccc(F)c(c1)C(C)(F)F
PDB
MMDB

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n/an/a 106n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
After thawing on the day of the assay, the membrane suspension was diluted further with 20 mM HEPES/0.1 mM KCl/pH 7.2.The incubation mixture of 200 &...


US Patent US10155727 (2018)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Rattus norvegicus (Rat))
BDBM310987
PNG
(US10155727, Example 41)
Show SMILES CCCc1cc(Cn2cc(cn2)-c2ccc(F)c(c2)C(F)F)n[nH]1
PDB

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n/an/a 114n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
After thawing on the day of the assay, a 5 ml membrane aliquot was centrifuged at 48000 g for 30 min at 4 C. The pellet was resuspended in 5 ml of 5...


US Patent US10155727 (2018)

More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM310987
PNG
(US10155727, Example 41)
Show SMILES CCCc1cc(Cn2cc(cn2)-c2ccc(F)c(c2)C(F)F)n[nH]1
PDB
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n/an/a 114n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
After thawing on the day of the assay, the membrane suspension was diluted further with 20 mM HEPES/0.1 mM KCl/pH 7.2.The incubation mixture of 200 &...


US Patent US10155727 (2018)

More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50201024
PNG
(CHEMBL3936854 | US10155727, Example 4)
Show SMILES Cn1cc(Cn2cc(cn2)-c2ccc(Cl)c(OC(F)F)c2)cn1
Show InChI InChI=1S/C15H13ClF2N4O/c1-21-7-10(5-19-21)8-22-9-12(6-20-22)11-2-3-13(16)14(4-11)23-15(17)18/h2-7,9,15H,8H2,1H3
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n/an/a 119n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
After thawing on the day of the assay, the membrane suspension was diluted further with 20 mM HEPES/0.1 mM KCl/pH 7.2.The incubation mixture of 200 &...


US Patent US10155727 (2018)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Rattus norvegicus (Rat))
BDBM50201024
PNG
(CHEMBL3936854 | US10155727, Example 4)
Show SMILES Cn1cc(Cn2cc(cn2)-c2ccc(Cl)c(OC(F)F)c2)cn1
Show InChI InChI=1S/C15H13ClF2N4O/c1-21-7-10(5-19-21)8-22-9-12(6-20-22)11-2-3-13(16)14(4-11)23-15(17)18/h2-7,9,15H,8H2,1H3
PDB

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n/an/a 119n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
After thawing on the day of the assay, a 5 ml membrane aliquot was centrifuged at 48000 g for 30 min at 4 C. The pellet was resuspended in 5 ml of 5...


US Patent US10155727 (2018)

More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 217 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%