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Patent code US10155731

Compile Data Set for Download or QSAR
Found 131 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Renin


(Homo sapiens (human))
BDBM212579
PNG
(US10155731, Example 270 | US9278944, 270)
Show SMILES COC(=O)NCCCn1nc([C@@H](C)N(C2CC2)C(=O)[C@H]2CNCCO2)c2ccc(C)nc12
Show InChI InChI=1S/C22H32N6O4/c1-14-5-8-17-19(26-27(20(17)25-14)11-4-9-24-22(30)31-3)15(2)28(16-6-7-16)21(29)18-13-23-10-12-32-18/h5,8,15-16,18,23H,4,6-7,9-13H2,1-3H3,(H,24,30)/t15-,18-/m1/s1
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n/an/a 0.400n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212499
PNG
(US10155731, Example 57 | US9278944, 57)
Show SMILES COCCCn1nc(C)c2c(cc(cc12)[C@@H](C)N(C1CC1)C(=O)[C@H]1CNCCO1)C(F)(F)F
Show InChI InChI=1S/C23H31F3N4O3/c1-14-21-18(23(24,25)26)11-16(12-19(21)29(28-14)8-4-9-32-3)15(2)30(17-5-6-17)22(31)20-13-27-7-10-33-20/h11-12,15,17,20,27H,4-10,13H2,1-3H3/t15-,20-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212584
PNG
(US10155731, Example 284 | US9278944, 284)
Show SMILES COC(=O)NCCCc1cc(cc(OC)n1)[C@@H](C)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C21H32N4O5/c1-14(25(17-6-7-17)20(26)18-13-22-9-10-30-18)15-11-16(24-19(12-15)28-2)5-4-8-23-21(27)29-3/h11-12,14,17-18,22H,4-10,13H2,1-3H3,(H,23,27)/t14-,18-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212482
PNG
(US10155731, Example 36 | US9278944, 36)
Show SMILES COCCCCn1cc([C@@H](C)N(C2CC2)C(=O)[C@H]2CNCCO2)c2ccc(C)nc12
Show InChI InChI=1S/C23H34N4O3/c1-16-6-9-19-20(15-26(22(19)25-16)11-4-5-12-29-3)17(2)27(18-7-8-18)23(28)21-14-24-10-13-30-21/h6,9,15,17-18,21,24H,4-5,7-8,10-14H2,1-3H3/t17-,21-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212512
PNG
(US10155731, Example 70 | US9278944, 70)
Show SMILES COCCCn1nc(C)c2c(F)cc(cc12)[C@@H](C)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C22H31FN4O3/c1-14-21-18(23)11-16(12-19(21)26(25-14)8-4-9-29-3)15(2)27(17-5-6-17)22(28)20-13-24-7-10-30-20/h11-12,15,17,20,24H,4-10,13H2,1-3H3/t15-,20-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212532
PNG
(US10155731, Example 97 | US9278944, 97)
Show SMILES COCCCCn1nc([C@@H](C)N(C2CC2)C(=O)[C@H]2CNCCO2)c2ccccc12
Show InChI InChI=1S/C22H32N4O3/c1-16(26(17-9-10-17)22(27)20-15-23-11-14-29-20)21-18-7-3-4-8-19(18)25(24-21)12-5-6-13-28-2/h3-4,7-8,16-17,20,23H,5-6,9-15H2,1-2H3/t16-,20-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212506
PNG
(US10155731, Example 64 | US9278944, 64)
Show SMILES COCCCCn1cc([C@@H](C)N(C2CC2)C(=O)[C@H]2CNCCO2)c2cccnc12
Show InChI InChI=1S/C22H32N4O3/c1-16(26(17-7-8-17)22(27)20-14-23-10-13-29-20)19-15-25(11-3-4-12-28-2)21-18(19)6-5-9-24-21/h5-6,9,15-17,20,23H,3-4,7-8,10-14H2,1-2H3/t16-,20-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212582
PNG
(US10155731, Example 280 | US9278944, 280)
Show SMILES COC(=O)NCCCc1cc(cnc1OC)[C@@H](C)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C21H32N4O5/c1-14(25(17-6-7-17)20(26)18-13-22-9-10-30-18)16-11-15(19(28-2)24-12-16)5-4-8-23-21(27)29-3/h11-12,14,17-18,22H,4-10,13H2,1-3H3,(H,23,27)/t14-,18-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212516
PNG
(US10155731, Example 78 | US9278944, 78)
Show SMILES COCCCn1cc(C)c2ccc(cc12)[C@@H](C)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C23H33N3O3/c1-16-15-25(10-4-11-28-3)21-13-18(5-8-20(16)21)17(2)26(19-6-7-19)23(27)22-14-24-9-12-29-22/h5,8,13,15,17,19,22,24H,4,6-7,9-12,14H2,1-3H3/t17-,22-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212517
PNG
(US10155731, Example 79 | US9278944, 79)
Show SMILES COCCCCn1cc([C@@H](C)N(C2CC2)C(=O)[C@H]2CNCCO2)c2cc(F)cnc12
Show InChI InChI=1S/C22H31FN4O3/c1-15(27(17-5-6-17)22(28)20-13-24-7-10-30-20)19-14-26(8-3-4-9-29-2)21-18(19)11-16(23)12-25-21/h11-12,14-15,17,20,24H,3-10,13H2,1-2H3/t15-,20-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212575
PNG
(US10155731, Example 152 | US9278944, 152)
Show SMILES COCCCCn1cc([C@@H](C)N(C2CC2)C(=O)[C@H]2CNCCO2)c2nccc(C)c12
Show InChI InChI=1S/C23H34N4O3/c1-16-8-9-25-21-19(15-26(22(16)21)11-4-5-12-29-3)17(2)27(18-6-7-18)23(28)20-14-24-10-13-30-20/h8-9,15,17-18,20,24H,4-7,10-14H2,1-3H3/t17-,20-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212466
PNG
(US10155731, Example 10 | US9278944, 10)
Show SMILES COCCCn1nc(C)c2ccc(cc12)[C@@H](C)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C22H32N4O3/c1-15-19-8-5-17(13-20(19)25(24-15)10-4-11-28-3)16(2)26(18-6-7-18)22(27)21-14-23-9-12-29-21/h5,8,13,16,18,21,23H,4,6-7,9-12,14H2,1-3H3/t16-,21-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM311173
PNG
(US10155731, Example 304)
Show SMILES COC(=O)NCCCc1cc(cc(OC(C)C)n1)[C@@H](C)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C23H36N4O5/c1-15(2)32-21-13-17(12-18(26-21)6-5-9-25-23(29)30-4)16(3)27(19-7-8-19)22(28)20-14-24-10-11-31-20/h12-13,15-16,19-20,24H,5-11,14H2,1-4H3,(H,25,29)/t16-,20-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212485
PNG
(US10155731, Example 39 | US9278944, 39)
Show SMILES COCCCn1nc(C)c2c(Cl)cc(cc12)[C@@H](C)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C22H31ClN4O3/c1-14-21-18(23)11-16(12-19(21)26(25-14)8-4-9-29-3)15(2)27(17-5-6-17)22(28)20-13-24-7-10-30-20/h11-12,15,17,20,24H,4-10,13H2,1-3H3/t15-,20-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212477
PNG
(US10155731, Example 28 | US9278944, 28)
Show SMILES COCCCn1cc(Cl)c2ccc(cc12)[C@@H](C)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C22H30ClN3O3/c1-15(26(17-5-6-17)22(27)21-13-24-8-11-29-21)16-4-7-18-19(23)14-25(20(18)12-16)9-3-10-28-2/h4,7,12,14-15,17,21,24H,3,5-6,8-11,13H2,1-2H3/t15-,21-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212488
PNG
(US10155731, Example 42 | US9278944, 42)
Show SMILES COC(=O)NCCCn1cc(C(C)N(C2CC2)C(=O)[C@H]2CNCCO2)c2cccnc12
Show InChI InChI=1S/C22H31N5O4/c1-15(27(16-6-7-16)21(28)19-13-23-10-12-31-19)18-14-26(11-4-9-25-22(29)30-2)20-17(18)5-3-8-24-20/h3,5,8,14-16,19,23H,4,6-7,9-13H2,1-2H3,(H,25,29)/t15?,19-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212509
PNG
(US10155731, Example 67 | US9278944, 67)
Show SMILES COC(=O)NCCOc1cc(cc2ccccc12)[C@@H](C)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C24H31N3O5/c1-16(27(19-7-8-19)23(28)22-15-25-9-11-32-22)18-13-17-5-3-4-6-20(17)21(14-18)31-12-10-26-24(29)30-2/h3-6,13-14,16,19,22,25H,7-12,15H2,1-2H3,(H,26,29)/t16-,22-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM311171
PNG
(US10155731, Example 299)
Show SMILES COCCOc1cc(cc(CCCNC(=O)OC)n1)[C@@H](C)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C23H36N4O6/c1-16(27(19-6-7-19)22(28)20-15-24-9-10-32-20)17-13-18(5-4-8-25-23(29)31-3)26-21(14-17)33-12-11-30-2/h13-14,16,19-20,24H,4-12,15H2,1-3H3,(H,25,29)/t16-,20-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212489
PNG
(US10155731, Example 43 | US9278944, 43)
Show SMILES COCCCOc1cc(cc2occc12)[C@@H](C)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C22H30N2O5/c1-15(24(17-4-5-17)22(25)21-14-23-7-11-29-21)16-12-19(27-9-3-8-26-2)18-6-10-28-20(18)13-16/h6,10,12-13,15,17,21,23H,3-5,7-9,11,14H2,1-2H3/t15-,21-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212497
PNG
(US10155731, Example 55 | US9278944, 55)
Show SMILES COCCCOc1cc(cc2OCCc12)[C@@H](C)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C22H32N2O5/c1-15(24(17-4-5-17)22(25)21-14-23-7-11-29-21)16-12-19(27-9-3-8-26-2)18-6-10-28-20(18)13-16/h12-13,15,17,21,23H,3-11,14H2,1-2H3/t15-,21-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212501
PNG
(US10155731, Example 59 | US9278944, 59)
Show SMILES COCCCn1ccc2ccc(cc12)[C@@H](C)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C22H31N3O3/c1-16(25(19-6-7-19)22(26)21-15-23-9-13-28-21)18-5-4-17-8-11-24(20(17)14-18)10-3-12-27-2/h4-5,8,11,14,16,19,21,23H,3,6-7,9-10,12-13,15H2,1-2H3/t16-,21-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212487
PNG
(US10155731, Example 41 | US9278944, 41)
Show SMILES COCCCn1nc(C)c2c(C)cc(cc12)[C@@H](C)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C23H34N4O3/c1-15-12-18(13-20-22(15)16(2)25-26(20)9-5-10-29-4)17(3)27(19-6-7-19)23(28)21-14-24-8-11-30-21/h12-13,17,19,21,24H,5-11,14H2,1-4H3/t17-,21-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212538
PNG
(US10155731, Example 103 | US9278944, 103)
Show SMILES COCCCOc1cc(cc2ccoc12)[C@@H](C)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C22H30N2O5/c1-15(24(18-4-5-18)22(25)20-14-23-7-11-28-20)17-12-16-6-10-29-21(16)19(13-17)27-9-3-8-26-2/h6,10,12-13,15,18,20,23H,3-5,7-9,11,14H2,1-2H3/t15-,20-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212508
PNG
(US10155731, Example 66 | US9278944, 66)
Show SMILES COC(=O)NCCOc1cc(cc2ccccc12)C(C)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C24H31N3O5/c1-16(27(19-7-8-19)23(28)22-15-25-9-11-32-22)18-13-17-5-3-4-6-20(17)21(14-18)31-12-10-26-24(29)30-2/h3-6,13-14,16,19,22,25H,7-12,15H2,1-2H3,(H,26,29)/t16?,22-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212563
PNG
(US10155731, Example 276 | US9278944, 139 | US92789...)
Show SMILES COCCCCc1cc(ccc1OC)[C@@H](C)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C22H34N2O4/c1-16(24(19-8-9-19)22(25)21-15-23-11-13-28-21)17-7-10-20(27-3)18(14-17)6-4-5-12-26-2/h7,10,14,16,19,21,23H,4-6,8-9,11-13,15H2,1-3H3/t16-,21-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212563
PNG
(US10155731, Example 276 | US9278944, 139 | US92789...)
Show SMILES COCCCCc1cc(ccc1OC)[C@@H](C)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C22H34N2O4/c1-16(24(19-8-9-19)22(25)21-15-23-11-13-28-21)17-7-10-20(27-3)18(14-17)6-4-5-12-26-2/h7,10,14,16,19,21,23H,4-6,8-9,11-13,15H2,1-3H3/t16-,21-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212586
PNG
(US10155731, Example 286 | US9278944, 286)
Show SMILES CCc1cc(cc(CCCNC(=O)OC)n1)[C@@H](C)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C22H34N4O4/c1-4-17-12-16(13-18(25-17)6-5-9-24-22(28)29-3)15(2)26(19-7-8-19)21(27)20-14-23-10-11-30-20/h12-13,15,19-20,23H,4-11,14H2,1-3H3,(H,24,28)/t15-,20-/m1/s1
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n/an/a 3n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212550
PNG
(US10155731, Example 124 | US9278944, 124)
Show SMILES COCCCn1ncc2ccc(cc12)[C@@H](C)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C21H30N4O3/c1-15(25(18-6-7-18)21(26)20-14-22-8-11-28-20)16-4-5-17-13-23-24(19(17)12-16)9-3-10-27-2/h4-5,12-13,15,18,20,22H,3,6-11,14H2,1-2H3/t15-,20-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM311172
PNG
(US10155731, Example 301)
Show SMILES COCCCc1cc(cc(CCCNC(=O)OC)n1)[C@@H](C)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C24H38N4O5/c1-17(28(21-8-9-21)23(29)22-16-25-11-13-33-22)18-14-19(6-4-10-26-24(30)32-3)27-20(15-18)7-5-12-31-2/h14-15,17,21-22,25H,4-13,16H2,1-3H3,(H,26,30)/t17-,22-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212554
PNG
(US10155731, Example 128 | US9278944, 128)
Show SMILES COCCCCn1nc([C@@H](C)N(C2CC2)C(=O)[C@H]2CNCCO2)c2cccnc12
Show InChI InChI=1S/C21H31N5O3/c1-15(26(16-7-8-16)21(27)18-14-22-10-13-29-18)19-17-6-5-9-23-20(17)25(24-19)11-3-4-12-28-2/h5-6,9,15-16,18,22H,3-4,7-8,10-14H2,1-2H3/t15-,18-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212577
PNG
(US10155731, Example 268 | US9278944, 268)
Show SMILES COC(=O)NCCCn1nc([C@@H](C)N(C2CC2)C(=O)[C@H]2CNCCO2)c2cccnc12
Show InChI InChI=1S/C21H30N6O4/c1-14(27(15-6-7-15)20(28)17-13-22-10-12-31-17)18-16-5-3-8-23-19(16)26(25-18)11-4-9-24-21(29)30-2/h3,5,8,14-15,17,22H,4,6-7,9-13H2,1-2H3,(H,24,29)/t14-,17-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212580
PNG
(US10155731, Example 271 | US9278944, 271)
Show SMILES COC(=O)NCCCn1nc([C@H](C)N(C2CC2)C(=O)[C@H]2CNCCO2)c2ccc(C)nc12
Show InChI InChI=1S/C22H32N6O4/c1-14-5-8-17-19(26-27(20(17)25-14)11-4-9-24-22(30)31-3)15(2)28(16-6-7-16)21(29)18-13-23-10-12-32-18/h5,8,15-16,18,23H,4,6-7,9-13H2,1-3H3,(H,24,30)/t15-,18+/m0/s1
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MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212484
PNG
(US10155731, Example 38 | US9278944, 38)
Show SMILES COCCCCn1cc([C@@H](C)N(C2CC2)C(=O)[C@H]2CNCCO2)c2c(F)ccnc12
Show InChI InChI=1S/C22H31FN4O3/c1-15(27(16-5-6-16)22(28)19-13-24-9-12-30-19)17-14-26(10-3-4-11-29-2)21-20(17)18(23)7-8-25-21/h7-8,14-16,19,24H,3-6,9-13H2,1-2H3/t15-,19-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212526
PNG
(US10155731, Example 89 | US9278944, 89)
Show SMILES COCCCOc1cc(cc(Br)c1OC)[C@@H](C)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C21H31BrN2O5/c1-14(24(16-5-6-16)21(25)19-13-23-7-10-29-19)15-11-17(22)20(27-3)18(12-15)28-9-4-8-26-2/h11-12,14,16,19,23H,4-10,13H2,1-3H3/t14-,19-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212565
PNG
(US10155731, Example 141 | US9278944, 141)
Show SMILES COCCCn1nc(F)c2ccc(cc12)[C@@H](C)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C21H29FN4O3/c1-14(26(16-5-6-16)21(27)19-13-23-8-11-29-19)15-4-7-17-18(12-15)25(24-20(17)22)9-3-10-28-2/h4,7,12,14,16,19,23H,3,5-6,8-11,13H2,1-2H3/t14-,19-/m1/s1
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n/an/a 4n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212545
PNG
(US10155731, Example 114 | US9278944, 114)
Show SMILES COCCCCn1cc(C(C)N(C2CC2)C(=O)[C@H]2CNCCO2)c2ncccc12
Show InChI InChI=1S/C22H32N4O3/c1-16(26(17-7-8-17)22(27)20-14-23-10-13-29-20)18-15-25(11-3-4-12-28-2)19-6-5-9-24-21(18)19/h5-6,9,15-17,20,23H,3-4,7-8,10-14H2,1-2H3/t16?,20-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212494
PNG
(US10155731, Example 52 | US9278944, 52)
Show SMILES COc1cc(nc2ccccc12)[C@@H](C)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C20H25N3O3/c1-13(17-11-18(25-2)15-5-3-4-6-16(15)22-17)23(14-7-8-14)20(24)19-12-21-9-10-26-19/h3-6,11,13-14,19,21H,7-10,12H2,1-2H3/t13-,19-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212533
PNG
(US10155731, Example 98 | US9278944, 98)
Show SMILES COCCCCn1nc([C@H](C)N(C2CC2)C(=O)[C@H]2CNCCO2)c2ccccc12
Show InChI InChI=1S/C22H32N4O3/c1-16(26(17-9-10-17)22(27)20-15-23-11-14-29-20)21-18-7-3-4-8-19(18)25(24-21)12-5-6-13-28-2/h3-4,7-8,16-17,20,23H,5-6,9-15H2,1-2H3/t16-,20+/m0/s1
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n/an/a 4.40n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212568
PNG
(US10155731, Example 144 | US9278944, 144)
Show SMILES COCCCOc1nc(nc2ccccc12)[C@@H](C)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C22H30N4O4/c1-15(26(16-8-9-16)22(27)19-14-23-10-13-29-19)20-24-18-7-4-3-6-17(18)21(25-20)30-12-5-11-28-2/h3-4,6-7,15-16,19,23H,5,8-14H2,1-2H3/t15-,19-/m1/s1
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n/an/a 4.80n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212478
PNG
(US10155731, Example 29 | US9278944, 29)
Show SMILES COCCCn1cc(Cl)c2ccc(cc12)[C@H](C)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C22H30ClN3O3/c1-15(26(17-5-6-17)22(27)21-13-24-8-11-29-21)16-4-7-18-19(23)14-25(20(18)12-16)9-3-10-28-2/h4,7,12,14-15,17,21,24H,3,5-6,8-11,13H2,1-2H3/t15-,21+/m0/s1
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MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212585
PNG
(US10155731, Example 285 | US9278944, 285)
Show SMILES COC(=O)NCCCc1cc(cc(OC)n1)[C@H](C)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C21H32N4O5/c1-14(25(17-6-7-17)20(26)18-13-22-9-10-30-18)15-11-16(24-19(12-15)28-2)5-4-8-23-21(27)29-3/h11-12,14,17-18,22H,4-10,13H2,1-3H3,(H,23,27)/t14-,18+/m0/s1
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MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212561
PNG
(US10155731, Example 137 | US9278944, 137)
Show SMILES COCCCn1cc(Cl)c2cnc(cc12)[C@@H](C)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C21H29ClN4O3/c1-14(26(15-4-5-15)21(27)20-12-23-6-9-29-20)18-10-19-16(11-24-18)17(22)13-25(19)7-3-8-28-2/h10-11,13-15,20,23H,3-9,12H2,1-2H3/t14-,20-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212507
PNG
(US10155731, Example 65 | US9278944, 65)
Show SMILES COCCCCn1cc([C@H](C)N(C2CC2)C(=O)[C@H]2CNCCO2)c2cccnc12
Show InChI InChI=1S/C22H32N4O3/c1-16(26(17-7-8-17)22(27)20-14-23-10-13-29-20)19-15-25(11-3-4-12-28-2)21-18(19)6-5-9-24-21/h5-6,9,15-17,20,23H,3-4,7-8,10-14H2,1-2H3/t16-,20+/m0/s1
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MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212578
PNG
(US10155731, Example 269 | US9278944, 269)
Show SMILES COC(=O)NCCCn1nc([C@H](C)N(C2CC2)C(=O)[C@H]2CNCCO2)c2cccnc12
Show InChI InChI=1S/C21H30N6O4/c1-14(27(15-6-7-15)20(28)17-13-22-10-12-31-17)18-16-5-3-8-23-19(16)26(25-18)11-4-9-24-21(29)30-2/h3,5,8,14-15,17,22H,4,6-7,9-13H2,1-2H3,(H,24,29)/t14-,17+/m0/s1
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n/an/a 6.60n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212483
PNG
(US10155731, Example 37 | US9278944, 37)
Show SMILES COCCCCn1cc([C@H](C)N(C2CC2)C(=O)[C@H]2CNCCO2)c2c(F)ccnc12
Show InChI InChI=1S/C22H31FN4O3/c1-15(27(16-5-6-16)22(28)19-13-24-9-12-30-19)17-14-26(10-3-4-11-29-2)21-20(17)18(23)7-8-25-21/h7-8,14-16,19,24H,3-6,9-13H2,1-2H3/t15-,19+/m0/s1
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n/an/a 6.60n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212552
PNG
(US10155731, Example 126 | US9278944, 126)
Show SMILES COCCCOc1cc(cc(Cl)c1OC)[C@@H](C)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C21H31ClN2O5/c1-14(24(16-5-6-16)21(25)19-13-23-7-10-29-19)15-11-17(22)20(27-3)18(12-15)28-9-4-8-26-2/h11-12,14,16,19,23H,4-10,13H2,1-3H3/t14-,19-/m1/s1
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n/an/a 6.60n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212583
PNG
(US10155731, Example 281 | US9278944, 281)
Show SMILES COC(=O)NCCCc1cc(cnc1OC)[C@H](C)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C21H32N4O5/c1-14(25(17-6-7-17)20(26)18-13-22-9-10-30-18)16-11-15(19(28-2)24-12-16)5-4-8-23-21(27)29-3/h11-12,14,17-18,22H,4-10,13H2,1-3H3,(H,23,27)/t14-,18+/m0/s1
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n/an/a 6.70n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212481
PNG
(US10155731, Example 35 | US9278944, 35)
Show SMILES COCCCOc1cc2[C@@H](CCc2cc1Br)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C21H29BrN2O4/c1-26-8-2-9-27-19-12-16-14(11-17(19)22)3-6-18(16)24(15-4-5-15)21(25)20-13-23-7-10-28-20/h11-12,15,18,20,23H,2-10,13H2,1H3/t18-,20-/m1/s1
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n/an/a 6.80n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212502
PNG
(US10155731, Example 60 | US9278944, 60)
Show SMILES COCCCN1CCc2ccc(cc12)[C@@H](C)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C22H33N3O3/c1-16(25(19-6-7-19)22(26)21-15-23-9-13-28-21)18-5-4-17-8-11-24(20(17)14-18)10-3-12-27-2/h4-5,14,16,19,21,23H,3,6-13,15H2,1-2H3/t16-,21-/m1/s1
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n/an/a 7n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212524
PNG
(US10155731, Example 87 | US9278944, 87)
Show SMILES COCCCCn1cc([C@H](C)N(C2CC2)C(=O)[C@H]2CNCCO2)c2ccc(C)nc12
Show InChI InChI=1S/C23H34N4O3/c1-16-6-9-19-20(15-26(22(19)25-16)11-4-5-12-29-3)17(2)27(18-7-8-18)23(28)21-14-24-10-13-30-21/h6,9,15,17-18,21,24H,4-5,7-8,10-14H2,1-3H3/t17-,21+/m0/s1
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n/an/a 7n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212534
PNG
(US10155731, Example 99 | US9278944, 99)
Show SMILES COCCCn1nc([C@@H](C)N(C2CC2)C(=O)[C@H]2CNCCO2)c2ccccc12
Show InChI InChI=1S/C21H30N4O3/c1-15(25(16-8-9-16)21(26)19-14-22-10-13-28-19)20-17-6-3-4-7-18(17)24(23-20)11-5-12-27-2/h3-4,6-7,15-16,19,22H,5,8-14H2,1-2H3/t15-,19-/m1/s1
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n/an/a 7.30n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212465
PNG
(US10155731, Example 9 | US9278944, 9)
Show SMILES COCCCOc1cc(OC)cc(c1)[C@@H](C)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C21H32N2O5/c1-15(23(17-5-6-17)21(24)20-14-22-7-10-28-20)16-11-18(26-3)13-19(12-16)27-9-4-8-25-2/h11-13,15,17,20,22H,4-10,14H2,1-3H3/t15-,20-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212540
PNG
(US10155731, Example 105 | US9278944, 105)
Show SMILES COCCCOc1cc(cc2CCOc12)[C@@H](C)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C22H32N2O5/c1-15(24(18-4-5-18)22(25)20-14-23-7-11-28-20)17-12-16-6-10-29-21(16)19(13-17)27-9-3-8-26-2/h12-13,15,18,20,23H,3-11,14H2,1-2H3/t15-,20-/m1/s1
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n/an/a 8.10n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212518
PNG
(US10155731, Example 80 | US9278944, 80)
Show SMILES COCCCCn1cc([C@H](C)N(C2CC2)C(=O)[C@H]2CNCCO2)c2cc(F)cnc12
Show InChI InChI=1S/C22H31FN4O3/c1-15(27(17-5-6-17)22(28)20-13-24-7-10-30-20)19-14-26(8-3-4-9-29-2)21-18(19)11-16(23)12-25-21/h11-12,14-15,17,20,24H,3-10,13H2,1-2H3/t15-,20+/m0/s1
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n/an/a 8.40n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212471
PNG
(US10155731, Example 21 | US9278944, 21)
Show SMILES COCCCOc1cc(ccc1OC)[C@@H](C)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C21H32N2O5/c1-15(23(17-6-7-17)21(24)20-14-22-9-12-28-20)16-5-8-18(26-3)19(13-16)27-11-4-10-25-2/h5,8,13,15,17,20,22H,4,6-7,9-12,14H2,1-3H3/t15-,20-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212491
PNG
(US10155731, Example 45 | US9278944, 45)
Show SMILES COCCCOc1cc(OCCCOC)cc(c1)[C@@H](C)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C24H38N2O6/c1-18(26(20-6-7-20)24(27)23-17-25-8-13-32-23)19-14-21(30-11-4-9-28-2)16-22(15-19)31-12-5-10-29-3/h14-16,18,20,23,25H,4-13,17H2,1-3H3/t18-,23-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212573
PNG
(US10155731, Example 150 | US9278944, 150)
Show SMILES COCCCOc1cc(ccc1OC(C)C)[C@@H](C)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C23H36N2O5/c1-16(2)30-20-9-6-18(14-21(20)28-12-5-11-27-4)17(3)25(19-7-8-19)23(26)22-15-24-10-13-29-22/h6,9,14,16-17,19,22,24H,5,7-8,10-13,15H2,1-4H3/t17-,22-/m1/s1
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n/an/a 8.70n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212564
PNG
(US10155731, Example 140 | US9278944, 140)
Show SMILES COCCCn1cc(C)c2cnc(cc12)C(C)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C22H32N4O3/c1-15-14-25(8-4-9-28-3)20-11-19(24-12-18(15)20)16(2)26(17-5-6-17)22(27)21-13-23-7-10-29-21/h11-12,14,16-17,21,23H,4-10,13H2,1-3H3/t16?,21-/m1/s1
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n/an/a 10n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212470
PNG
(US10155731, Example 19 | US9278944, 19)
Show SMILES COCCCOc1cc(ccc1C)[C@@H](C)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C21H32N2O4/c1-15-5-6-17(13-19(15)26-11-4-10-25-3)16(2)23(18-7-8-18)21(24)20-14-22-9-12-27-20/h5-6,13,16,18,20,22H,4,7-12,14H2,1-3H3/t16-,20-/m1/s1
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n/an/a 10n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212559
PNG
(US10155731, Example 135 | US9278944, 135)
Show SMILES COCCCOc1cc(ccc1OC(F)F)[C@@H](C)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C21H30F2N2O5/c1-14(25(16-5-6-16)20(26)19-13-24-8-11-29-19)15-4-7-17(30-21(22)23)18(12-15)28-10-3-9-27-2/h4,7,12,14,16,19,21,24H,3,5-6,8-11,13H2,1-2H3/t14-,19-/m1/s1
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n/an/a 11n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212522
PNG
(US10155731, Example 85 | US9278944, 85)
Show SMILES COCCCOc1cc(cc(F)c1OC)[C@@H](C)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C21H31FN2O5/c1-14(24(16-5-6-16)21(25)19-13-23-7-10-29-19)15-11-17(22)20(27-3)18(12-15)28-9-4-8-26-2/h11-12,14,16,19,23H,4-10,13H2,1-3H3/t14-,19-/m1/s1
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n/an/a 11n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM311174
PNG
(US10155731, Example 305)
Show SMILES CCc1nc(cc2n(CCCOC)cc(c12)C(F)(F)F)[C@@H](C)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C24H33F3N4O3/c1-4-18-22-17(24(25,26)27)14-30(9-5-10-33-3)20(22)12-19(29-18)15(2)31(16-6-7-16)23(32)21-13-28-8-11-34-21/h12,14-16,21,28H,4-11,13H2,1-3H3/t15-,21-/m1/s1
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n/an/a 12n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212551
PNG
(US10155731, Example 125 | US9278944, 125)
Show SMILES COCCCn1ncc2ccc(cc12)[C@H](C)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C21H30N4O3/c1-15(25(18-6-7-18)21(26)20-14-22-8-11-28-20)16-4-5-17-13-23-24(19(17)12-16)9-3-10-27-2/h4-5,12-13,15,18,20,22H,3,6-11,14H2,1-2H3/t15-,20+/m0/s1
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n/an/a 12n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212562
PNG
(US10155731, Example 138 | US9278944, 138)
Show SMILES COCCCn1cc(Cl)c2cnc(cc12)[C@H](C)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C21H29ClN4O3/c1-14(26(15-4-5-15)21(27)20-12-23-6-9-29-20)18-10-19-16(11-24-18)17(22)13-25(19)7-3-8-28-2/h10-11,13-15,20,23H,3-9,12H2,1-2H3/t14-,20+/m0/s1
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n/an/a 12n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212479
PNG
(BDBM212504 | US10155731, Example 62 | US9278944, 3...)
Show SMILES COCCCn1cc(Cl)c2ccc(cc12)[C@@H](C)N(C1CC1)C(=O)[C@H]1CNCCN1
Show InChI InChI=1S/C22H31ClN4O2/c1-15(27(17-5-6-17)22(28)20-13-24-8-9-25-20)16-4-7-18-19(23)14-26(21(18)12-16)10-3-11-29-2/h4,7,12,14-15,17,20,24-25H,3,5-6,8-11,13H2,1-2H3/t15-,20-/m1/s1
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n/an/a 12n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212462
PNG
(US10155731, Example 6 | US9278944, 6)
Show SMILES COCCCOc1cc(OC)cc(c1)C(C)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C21H32N2O5/c1-15(23(17-5-6-17)21(24)20-14-22-7-10-28-20)16-11-18(26-3)13-19(12-16)27-9-4-8-25-2/h11-13,15,17,20,22H,4-10,14H2,1-3H3/t15?,20-/m1/s1
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n/an/a 13n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212463
PNG
(US10155731, Example 7 | US9278944, 7)
Show SMILES C[C@@H](N(C1CC1)C(=O)[C@H]1CNCCO1)c1ccc2ccccc2c1
Show InChI InChI=1S/C20H24N2O2/c1-14(16-7-6-15-4-2-3-5-17(15)12-16)22(18-8-9-18)20(23)19-13-21-10-11-24-19/h2-7,12,14,18-19,21H,8-11,13H2,1H3/t14-,19-/m1/s1
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n/an/a 13n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212572
PNG
(US10155731, Example 149 | US9278944, 149)
Show SMILES CCOc1ccc(cc1OCCCOC)[C@@H](C)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C22H34N2O5/c1-4-27-19-9-6-17(14-20(19)28-12-5-11-26-3)16(2)24(18-7-8-18)22(25)21-15-23-10-13-29-21/h6,9,14,16,18,21,23H,4-5,7-8,10-13,15H2,1-3H3/t16-,21-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212486
PNG
(US10155731, Example 40 | US9278944, 40)
Show SMILES COCCCn1nc(C)c2c(Cl)cc(cc12)[C@H](C)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C22H31ClN4O3/c1-14-21-18(23)11-16(12-19(21)26(25-14)8-4-9-29-3)15(2)27(17-5-6-17)22(28)20-13-24-7-10-30-20/h11-12,15,17,20,24H,4-10,13H2,1-3H3/t15-,20+/m0/s1
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n/an/a 14n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212503
PNG
(US10155731, Example 61 | US9278944, 61)
Show SMILES COCCCn1ccc2ccc(cc12)[C@H](C)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C22H31N3O3/c1-16(25(19-6-7-19)22(26)21-15-23-9-13-28-21)18-5-4-17-8-11-24(20(17)14-18)10-3-12-27-2/h4-5,8,11,14,16,19,21,23H,3,6-7,9-10,12-13,15H2,1-2H3/t16-,21+/m0/s1
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MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212553
PNG
(US10155731, Example 127 | US9278944, 127)
Show SMILES COCCCOc1cc(cc(Cl)c1OC)C(C)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C21H31ClN2O5/c1-14(24(16-5-6-16)21(25)19-13-23-7-10-29-19)15-11-17(22)20(27-3)18(12-15)28-9-4-8-26-2/h11-12,14,16,19,23H,4-10,13H2,1-3H3/t14?,19-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212528
PNG
(US10155731, Example 91 | US9278944, 91)
Show SMILES COCCCn1nc(C)c2c(Cl)cc(cc12)C(C)N(C1CC1)C(=O)[C@H]1CNCCN1
Show InChI InChI=1S/C22H32ClN5O2/c1-14-21-18(23)11-16(12-20(21)27(26-14)9-4-10-30-3)15(2)28(17-5-6-17)22(29)19-13-24-7-8-25-19/h11-12,15,17,19,24-25H,4-10,13H2,1-3H3/t15?,19-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212520
PNG
(US10155731, Example 82 | US9278944, 82)
Show SMILES COCCCn1cc(C)c2ccc(cc12)[C@@H](C)N(C1CC1)C(=O)[C@H]1CNCCN1
Show InChI InChI=1S/C23H34N4O2/c1-16-15-26(11-4-12-29-3)22-13-18(5-8-20(16)22)17(2)27(19-6-7-19)23(28)21-14-24-9-10-25-21/h5,8,13,15,17,19,21,24-25H,4,6-7,9-12,14H2,1-3H3/t17-,21-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212547
PNG
(US10155731, Example 116 | US9278944, 116)
Show SMILES COCCCCn1cc(C(C)N(C2CC2)C(=O)C2CCNC2)c2ccc(C)nc12
Show InChI InChI=1S/C23H34N4O2/c1-16-6-9-20-21(15-26(22(20)25-16)12-4-5-13-29-3)17(2)27(19-7-8-19)23(28)18-10-11-24-14-18/h6,9,15,17-19,24H,4-5,7-8,10-14H2,1-3H3
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MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212556
PNG
(US10155731, Example 133 | US9278944, 132)
Show SMILES COCCCOc1cc(ccc1OCc1ccccc1)[C@@H](C)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C27H36N2O5/c1-20(29(23-10-11-23)27(30)26-18-28-13-16-33-26)22-9-12-24(25(17-22)32-15-6-14-31-2)34-19-21-7-4-3-5-8-21/h3-5,7-9,12,17,20,23,26,28H,6,10-11,13-16,18-19H2,1-2H3/t20-,26-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212523
PNG
(US10155731, Example 86 | US9278944, 86)
Show SMILES COCCCOc1cc(cc(c1)C(F)(F)F)[C@@H](C)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C21H29F3N2O4/c1-14(26(17-4-5-17)20(27)19-13-25-6-9-30-19)15-10-16(21(22,23)24)12-18(11-15)29-8-3-7-28-2/h10-12,14,17,19,25H,3-9,13H2,1-2H3/t14-,19-/m1/s1
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n/an/a 16n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212500
PNG
(US10155731, Example 58 | US9278944, 58)
Show SMILES COCCCn1nc(C)c2c(cc(cc12)[C@H](C)N(C1CC1)C(=O)[C@H]1CNCCO1)C(F)(F)F
Show InChI InChI=1S/C23H31F3N4O3/c1-14-21-18(23(24,25)26)11-16(12-19(21)29(28-14)8-4-9-32-3)15(2)30(17-5-6-17)22(31)20-13-27-7-10-33-20/h11-12,15,17,20,27H,4-10,13H2,1-3H3/t15-,20+/m0/s1
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n/an/a 16n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212571
PNG
(US10155731, Example 147 | US9278944, 147)
Show SMILES COCCOCCn1nc([C@@H](C)N(C2CC2)C(=O)[C@H]2CNCCO2)c2ccccc12
Show InChI InChI=1S/C22H32N4O4/c1-16(26(17-7-8-17)22(27)20-15-23-9-11-30-20)21-18-5-3-4-6-19(18)25(24-21)10-12-29-14-13-28-2/h3-6,16-17,20,23H,7-15H2,1-2H3/t16-,20-/m1/s1
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n/an/a 16n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212492
PNG
(US10155731, Example 46 | US9278944, 46)
Show SMILES COCCCOc1cc(OCCCOC)cc(c1)C(C)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C24H38N2O6/c1-18(26(20-6-7-20)24(27)23-17-25-8-13-32-23)19-14-21(30-11-4-9-28-2)16-22(15-19)31-12-5-10-29-3/h14-16,18,20,23,25H,4-13,17H2,1-3H3/t18?,23-/m1/s1
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n/an/a 17n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212566
PNG
(US10155731, Example 142 | US9278944, 142)
Show SMILES COCCCn1nc(F)c2ccc(cc12)[C@H](C)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C21H29FN4O3/c1-14(26(16-5-6-16)21(27)19-13-23-8-11-29-19)15-4-7-17-18(12-15)25(24-20(17)22)9-3-10-28-2/h4,7,12,14,16,19,23H,3,5-6,8-11,13H2,1-2H3/t14-,19+/m0/s1
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n/an/a 17n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212474
PNG
(US10155731, Example 25 | US9278944, 25)
Show SMILES COCCCOc1cc(C)cc(c1)[C@@H](C)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C21H32N2O4/c1-15-11-17(13-19(12-15)26-9-4-8-25-3)16(2)23(18-5-6-18)21(24)20-14-22-7-10-27-20/h11-13,16,18,20,22H,4-10,14H2,1-3H3/t16-,20-/m1/s1
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n/an/a 19n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212548
PNG
(US10155731, Example 122 | US9278944, 122)
Show SMILES COCCCOc1cc(cc2occc12)[C@H](C)N(C1CC1)C(=O)C1CCNC1
Show InChI InChI=1S/C22H30N2O4/c1-15(24(18-4-5-18)22(25)16-6-8-23-14-16)17-12-20(27-10-3-9-26-2)19-7-11-28-21(19)13-17/h7,11-13,15-16,18,23H,3-6,8-10,14H2,1-2H3/t15-,16?/m0/s1
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n/an/a 19n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212556
PNG
(US10155731, Example 133 | US9278944, 132)
Show SMILES COCCCOc1cc(ccc1OCc1ccccc1)[C@@H](C)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C27H36N2O5/c1-20(29(23-10-11-23)27(30)26-18-28-13-16-33-26)22-9-12-24(25(17-22)32-15-6-14-31-2)34-19-21-7-4-3-5-8-21/h3-5,7-9,12,17,20,23,26,28H,6,10-11,13-16,18-19H2,1-2H3/t20-,26-/m1/s1
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n/an/a 20n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212511
PNG
(US10155731, Example 69 | US9278944, 69)
Show SMILES COCCCn1nc(C)c2c(C)cc(cc12)[C@H](C)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C23H34N4O3/c1-15-12-18(13-20-22(15)16(2)25-26(20)9-5-10-29-4)17(3)27(19-6-7-19)23(28)21-14-24-8-11-30-21/h12-13,17,19,21,24H,5-11,14H2,1-4H3/t17-,21+/m0/s1
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n/an/a 21n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212513
PNG
(US10155731, Example 71 | US9278944, 71)
Show SMILES COCCCn1nc(C)c2c(F)cc(cc12)[C@H](C)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C22H31FN4O3/c1-14-21-18(23)11-16(12-19(21)26(25-14)8-4-9-29-3)15(2)27(17-5-6-17)22(28)20-13-24-7-10-30-20/h11-12,15,17,20,24H,4-10,13H2,1-3H3/t15-,20+/m0/s1
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n/an/a 21n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212519
PNG
(US10155731, Example 81 | US9278944, 81)
Show SMILES COCCCOc1cc(cc2occc12)[C@@H](C)N(C1CC1)C(=O)[C@H]1CNCCN1
Show InChI InChI=1S/C22H31N3O4/c1-15(25(17-4-5-17)22(26)19-14-23-7-8-24-19)16-12-20(28-10-3-9-27-2)18-6-11-29-21(18)13-16/h6,11-13,15,17,19,23-24H,3-5,7-10,14H2,1-2H3/t15-,19-/m1/s1
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n/an/a 25n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212570
PNG
(US10155731, Example 146 | US9278944, 146)
Show SMILES COCCCn1ccc2ncc(cc12)[C@@H](C)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C21H30N4O3/c1-15(25(17-4-5-17)21(26)20-14-22-7-11-28-20)16-12-19-18(23-13-16)6-9-24(19)8-3-10-27-2/h6,9,12-13,15,17,20,22H,3-5,7-8,10-11,14H2,1-2H3/t15-,20-/m1/s1
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n/an/a 28n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212536
PNG
(US10155731, Example 101 | US9278944, 101)
Show SMILES COCCCOc1cc(cc2onc(C)c12)[C@@H](C)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C22H31N3O5/c1-14-21-18(28-9-4-8-27-3)11-16(12-19(21)30-24-14)15(2)25(17-5-6-17)22(26)20-13-23-7-10-29-20/h11-12,15,17,20,23H,4-10,13H2,1-3H3/t15-,20-/m1/s1
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n/an/a 29n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212490
PNG
(US10155731, Example 44 | US9278944, 44)
Show SMILES COCCCOc1cc(cc2occc12)[C@H](C)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C22H30N2O5/c1-15(24(17-4-5-17)22(25)21-14-23-7-11-29-21)16-12-19(27-9-3-8-26-2)18-6-10-28-20(18)13-16/h6,10,12-13,15,17,21,23H,3-5,7-9,11,14H2,1-2H3/t15-,21+/m0/s1
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n/an/a 30n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212479
PNG
(BDBM212504 | US10155731, Example 62 | US9278944, 3...)
Show SMILES COCCCn1cc(Cl)c2ccc(cc12)[C@@H](C)N(C1CC1)C(=O)[C@H]1CNCCN1
Show InChI InChI=1S/C22H31ClN4O2/c1-15(27(17-5-6-17)22(28)20-13-24-8-9-25-20)16-4-7-18-19(23)14-26(21(18)12-16)10-3-11-29-2/h4,7,12,14-15,17,20,24-25H,3,5-6,8-11,13H2,1-2H3/t15-,20-/m1/s1
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n/an/a 30n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212496
PNG
(US10155731, Example 54 | US9278944, 54)
Show SMILES COc1cc(cc2ccccc12)[C@H](C)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C21H26N2O3/c1-14(16-11-15-5-3-4-6-18(15)19(12-16)25-2)23(17-7-8-17)21(24)20-13-22-9-10-26-20/h3-6,11-12,14,17,20,22H,7-10,13H2,1-2H3/t14-,20+/m0/s1
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n/an/a 31n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212560
PNG
(US10155731, Example 136 | US9278944, 136)
Show SMILES COCCCn1ccc2cnc(cc12)C(C)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C21H30N4O3/c1-15(25(17-4-5-17)21(26)20-14-22-7-11-28-20)18-12-19-16(13-23-18)6-9-24(19)8-3-10-27-2/h6,9,12-13,15,17,20,22H,3-5,7-8,10-11,14H2,1-2H3/t15?,20-/m1/s1
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n/an/a 33n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212574
PNG
(US10155731, Example 151 | US9278944, 151)
Show SMILES COCCCOc1ccc(cc1OCCCOC)[C@@H](C)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C24H38N2O6/c1-18(26(20-7-8-20)24(27)23-17-25-10-15-32-23)19-6-9-21(30-13-4-11-28-2)22(16-19)31-14-5-12-29-3/h6,9,16,18,20,23,25H,4-5,7-8,10-15,17H2,1-3H3/t18-,23-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212498
PNG
(US10155731, Example 56 | US9278944, 56)
Show SMILES COCCCOc1cc(cc2OCCc12)[C@H](C)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C22H32N2O5/c1-15(24(17-4-5-17)22(25)21-14-23-7-11-29-21)16-12-19(27-9-3-8-26-2)18-6-10-28-20(18)13-16/h12-13,15,17,21,23H,3-11,14H2,1-2H3/t15-,21+/m0/s1
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n/an/a 35n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212587
PNG
(US10155731, Example 287 | US9278944, 287)
Show SMILES CCc1cc(cc(CCCNC(=O)OC)n1)[C@H](C)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C22H34N4O4/c1-4-17-12-16(13-18(25-17)6-5-9-24-22(28)29-3)15(2)26(19-7-8-19)21(27)20-14-23-10-11-30-20/h12-13,15,19-20,23H,4-11,14H2,1-3H3,(H,24,28)/t15-,20+/m0/s1
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n/an/a 35n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212515
PNG
(US10155731, Example 76 | US9278944, 76)
Show SMILES COCCCOc1cc(cc2occc12)C(C)N(C1CC1)C(=O)[C@H]1CNCCN1
Show InChI InChI=1S/C22H31N3O4/c1-15(25(17-4-5-17)22(26)19-14-23-7-8-24-19)16-12-20(28-10-3-9-27-2)18-6-11-29-21(18)13-16/h6,11-13,15,17,19,23-24H,3-5,7-10,14H2,1-2H3/t15?,19-/m1/s1
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n/an/a 37n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM311113
PNG
(US10155731, Example 93)
Show SMILES COCCCn1cc(C)c2c(C)cc(cc12)[C@@H](C)N(C1CC1)C(=O)[C@H]1CNCCN1
Show InChI InChI=1S/C24H36N4O2/c1-16-12-19(13-22-23(16)17(2)15-27(22)10-5-11-30-4)18(3)28(20-6-7-20)24(29)21-14-25-8-9-26-21/h12-13,15,18,20-21,25-26H,5-11,14H2,1-4H3/t18-,21-/m1/s1
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n/an/a 41n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212535
PNG
(US10155731, Example 100 | US9278944, 100)
Show SMILES COCCCn1nc([C@H](C)N(C2CC2)C(=O)[C@H]2CNCCO2)c2ccccc12
Show InChI InChI=1S/C21H30N4O3/c1-15(25(16-8-9-16)21(26)19-14-22-10-13-28-19)20-17-6-3-4-7-18(17)24(23-20)11-5-12-27-2/h3-4,6-7,15-16,19,22H,5,8-14H2,1-2H3/t15-,19+/m0/s1
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n/an/a 41n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212549
PNG
(US10155731, Example 123 | US9278944, 123)
Show SMILES COCCCOc1cc(cc2occc12)C(C)N(C1CC1)C(=O)C1CCNC1
Show InChI InChI=1S/C22H30N2O4/c1-15(24(18-4-5-18)22(25)16-6-8-23-14-16)17-12-20(27-10-3-9-26-2)19-7-11-28-21(19)13-17/h7,11-13,15-16,18,23H,3-6,8-10,14H2,1-2H3
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n/an/a 42n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212555
PNG
(US10155731, Example 129 | US9278944, 129)
Show SMILES COCCCCn1nc([C@H](C)N(C2CC2)C(=O)[C@H]2CNCCO2)c2cccnc12
Show InChI InChI=1S/C21H31N5O3/c1-15(26(16-7-8-16)21(27)18-14-22-10-13-29-18)19-17-6-5-9-23-20(17)25(24-19)11-3-4-12-28-2/h5-6,9,15-16,18,22H,3-4,7-8,10-14H2,1-2H3/t15-,18+/m0/s1
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n/an/a 42n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212469
PNG
(US10155731, Example 18 | US9278944, 18)
Show SMILES COCCCOc1ccc2CC[C@@H](N(C3CC3)C(=O)[C@H]3CNCCO3)c2c1
Show InChI InChI=1S/C21H30N2O4/c1-25-10-2-11-26-17-7-3-15-4-8-19(18(15)13-17)23(16-5-6-16)21(24)20-14-22-9-12-27-20/h3,7,13,16,19-20,22H,2,4-6,8-12,14H2,1H3/t19-,20-/m1/s1
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n/an/a 44n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212576
PNG
(US10155731, Example 153 | US9278944, 153)
Show SMILES COCCCCn1cc([C@H](C)N(C2CC2)C(=O)[C@H]2CNCCO2)c2nccc(C)c12
Show InChI InChI=1S/C23H34N4O3/c1-16-8-9-25-21-19(15-26(22(16)21)11-4-5-12-29-3)17(2)27(18-6-7-18)23(28)20-14-24-10-13-30-20/h8-9,15,17-18,20,24H,4-7,10-14H2,1-3H3/t17-,20+/m0/s1
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n/an/a 46n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212525
PNG
(US10155731, Example 88 | US9278944, 88)
Show SMILES COCCCOc1cc2[C@@H](CCCc2cc1Br)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C22H31BrN2O4/c1-27-9-3-10-28-20-13-17-15(12-18(20)23)4-2-5-19(17)25(16-6-7-16)22(26)21-14-24-8-11-29-21/h12-13,16,19,21,24H,2-11,14H2,1H3/t19-,21-/m1/s1
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n/an/a 52n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212567
PNG
(US10155731, Example 143 | US9278944, 143)
Show SMILES COCCCn1nc(C)c2ccc(cc12)[C@@H](C)N(C1CC1)C(=O)[C@H]1CNCCN1
Show InChI InChI=1S/C22H33N5O2/c1-15-19-8-5-17(13-21(19)26(25-15)11-4-12-29-3)16(2)27(18-6-7-18)22(28)20-14-23-9-10-24-20/h5,8,13,16,18,20,23-24H,4,6-7,9-12,14H2,1-3H3/t16-,20-/m1/s1
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n/an/a 58n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212529
PNG
(US10155731, Example 92 | US9278944, 92)
Show SMILES COCCCn1nc(C)c2c(Cl)cc(cc12)[C@H](C)N(C1CC1)C(=O)[C@H]1CNCCN1
Show InChI InChI=1S/C22H32ClN5O2/c1-14-21-18(23)11-16(12-20(21)27(26-14)9-4-10-30-3)15(2)28(17-5-6-17)22(29)19-13-24-7-8-25-19/h11-12,15,17,19,24-25H,4-10,13H2,1-3H3/t15-,19+/m0/s1
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n/an/a 62n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212569
PNG
(US10155731, Example 145 | US9278944, 145)
Show SMILES COCCCOc1nc(nc2ccccc12)[C@H](C)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C22H30N4O4/c1-15(26(16-8-9-16)22(27)19-14-23-10-13-29-19)20-24-18-7-4-3-6-17(18)21(25-20)30-12-5-11-28-2/h3-4,6-7,15-16,19,23H,5,8-14H2,1-2H3/t15-,19+/m0/s1
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n/an/a 63n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212543
PNG
(US10155731, Example 110 | US9278944, 110)
Show SMILES COCCCOc1cc(cc2cnn(C)c12)[C@@H](C)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C22H32N4O4/c1-15(26(18-5-6-18)22(27)20-14-23-7-10-30-20)16-11-17-13-24-25(2)21(17)19(12-16)29-9-4-8-28-3/h11-13,15,18,20,23H,4-10,14H2,1-3H3/t15-,20-/m1/s1
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n/an/a 67n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212527
PNG
(US10155731, Example 90 | US9278944, 90)
Show SMILES COCCCOc1cc(cc(Br)c1OC)[C@H](C)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C21H31BrN2O5/c1-14(24(16-5-6-16)21(25)19-13-23-7-10-29-19)15-11-17(22)20(27-3)18(12-15)28-9-4-8-26-2/h11-12,14,16,19,23H,4-10,13H2,1-3H3/t14-,19+/m0/s1
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n/an/a 71n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212495
PNG
(US10155731, Example 53 | US9278944, 53)
Show SMILES COc1cc(nc2ccccc12)[C@H](C)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C20H25N3O3/c1-13(17-11-18(25-2)15-5-3-4-6-16(15)22-17)23(14-7-8-14)20(24)19-12-21-9-10-26-19/h3-6,11,13-14,19,21H,7-10,12H2,1-2H3/t13-,19+/m0/s1
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n/an/a 72n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212467
PNG
(US10155731, Example 12 | US9278944, 12)
Show SMILES COc1cc(OC)cc(c1)C(C)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C18H26N2O4/c1-12(13-8-15(22-2)10-16(9-13)23-3)20(14-4-5-14)18(21)17-11-19-6-7-24-17/h8-10,12,14,17,19H,4-7,11H2,1-3H3/t12?,17-/m1/s1
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n/an/a 73n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212514
PNG
(US10155731, Example 75 | US9278944, 75)
Show SMILES COCCCn1nc(C)c2ccc(cc12)C(C)N(C1CC1)C(=O)[C@H]1CNCCN1
Show InChI InChI=1S/C22H33N5O2/c1-15-19-8-5-17(13-21(19)26(25-15)11-4-12-29-3)16(2)27(18-6-7-18)22(28)20-14-23-9-10-24-20/h5,8,13,16,18,20,23-24H,4,6-7,9-12,14H2,1-3H3/t16?,20-/m1/s1
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n/an/a 78n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212546
PNG
(US10155731, Example 115 | US9278944, 115)
Show SMILES COCCCCn1cc(C(C)N(C2CC2)C(=O)C2CCNC2)c2cc(F)cnc12
Show InChI InChI=1S/C22H31FN4O2/c1-15(27(18-5-6-18)22(28)16-7-8-24-12-16)20-14-26(9-3-4-10-29-2)21-19(20)11-17(23)13-25-21/h11,13-16,18,24H,3-10,12H2,1-2H3
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n/an/a 87n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212539
PNG
(US10155731, Example 104 | US9278944, 104)
Show SMILES COCCCOc1cc(cc2ccoc12)[C@H](C)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C22H30N2O5/c1-15(24(18-4-5-18)22(25)20-14-23-7-11-28-20)17-12-16-6-10-29-21(16)19(13-17)27-9-3-8-26-2/h6,10,12-13,15,18,20,23H,3-5,7-9,11,14H2,1-2H3/t15-,20+/m0/s1
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n/an/a 89n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212493
PNG
(US10155731, Example 49 | US9278944, 49)
Show SMILES COc1cc(cc(Cl)c1OC)[C@@H](C)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C18H25ClN2O4/c1-11(12-8-14(19)17(24-3)15(9-12)23-2)21(13-4-5-13)18(22)16-10-20-6-7-25-16/h8-9,11,13,16,20H,4-7,10H2,1-3H3/t11-,16-/m1/s1
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n/an/a 89n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212531
PNG
(US10155731, Example 94 | US9278944, 94)
Show SMILES COCCCn1nc(C)c2c(C)cc(cc12)C(C)N(C1CC1)C(=O)[C@H]1CNCCN1
Show InChI InChI=1S/C23H35N5O2/c1-15-12-18(13-21-22(15)16(2)26-27(21)10-5-11-30-4)17(3)28(19-6-7-19)23(29)20-14-24-8-9-25-20/h12-13,17,19-20,24-25H,5-11,14H2,1-4H3/t17?,20-/m1/s1
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n/an/a 120n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212510
PNG
(US10155731, Example 68 | US9278944, 68)
Show SMILES COCCCn1nc(C)c2ccc(cc12)C(C)N(C1CC1)C(=O)C1CCNC1
Show InChI InChI=1S/C22H32N4O2/c1-15-20-8-5-17(13-21(20)25(24-15)11-4-12-28-3)16(2)26(19-6-7-19)22(27)18-9-10-23-14-18/h5,8,13,16,18-19,23H,4,6-7,9-12,14H2,1-3H3
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n/an/a 140n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212468
PNG
(US10155731, Example 17 | US9278944, 17)
Show SMILES COCCCn1nc(C)c2ccc(cc12)[C@H](C)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C22H32N4O3/c1-15-19-8-5-17(13-20(19)25(24-15)10-4-11-28-3)16(2)26(18-6-7-18)22(27)21-14-23-9-12-29-21/h5,8,13,16,18,21,23H,4,6-7,9-12,14H2,1-3H3/t16-,21+/m0/s1
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n/an/a 210n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM311175
PNG
(US10155731, Example 306)
Show SMILES CCc1nc(cc2n(CCCOC)cc(c12)C(F)(F)F)[C@H](C)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C24H33F3N4O3/c1-4-18-22-17(24(25,26)27)14-30(9-5-10-33-3)20(22)12-19(29-18)15(2)31(16-6-7-16)23(32)21-13-28-8-11-34-21/h12,14-16,21,28H,4-11,13H2,1-3H3/t15-,21+/m0/s1
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n/an/a 230n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212473
PNG
(US10155731, Example 24 | US9278944, 24)
Show SMILES COCCCOc1cc(ccc1OC)[C@H](C)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C21H32N2O5/c1-15(23(17-6-7-17)21(24)20-14-22-9-12-28-20)16-5-8-18(26-3)19(13-16)27-11-4-10-25-2/h5,8,13,15,17,20,22H,4,6-7,9-12,14H2,1-3H3/t15-,20+/m0/s1
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n/an/a 240n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212558
PNG
(US10155731, Example 134 | US9278944, 134)
Show SMILES COCCCn1nc(C)c2c(cc(cc12)[C@H](C)N(C1CC1)C(=O)[C@H]1CNCCO1)-c1c(C)noc1C
Show InChI InChI=1S/C27H37N5O4/c1-16-26-22(25-17(2)30-36-19(25)4)13-20(14-23(26)31(29-16)10-6-11-34-5)18(3)32(21-7-8-21)27(33)24-15-28-9-12-35-24/h13-14,18,21,24,28H,6-12,15H2,1-5H3/t18-,24+/m0/s1
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n/an/a 250n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212472
PNG
(US10155731, Example 22 | US9278944, 22)
Show SMILES COCCCOc1cc(ccc1C)[C@H](C)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C21H32N2O4/c1-15-5-6-17(13-19(15)26-11-4-10-25-3)16(2)23(18-7-8-18)21(24)20-14-22-9-12-27-20/h5-6,13,16,18,20,22H,4,7-12,14H2,1-3H3/t16-,20+/m0/s1
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n/an/a 270n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212537
PNG
(US10155731, Example 102 | US9278944, 102)
Show SMILES COCCCOc1cc(cc2onc(C)c12)[C@H](C)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C22H31N3O5/c1-14-21-18(28-9-4-8-27-3)11-16(12-19(21)30-24-14)15(2)25(17-5-6-17)22(26)20-13-23-7-10-29-20/h11-12,15,17,20,23H,4-10,13H2,1-3H3/t15-,20+/m0/s1
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n/an/a 290n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212476
PNG
(US10155731, Example 27 | US9278944, 27)
Show SMILES COCCCOc1ccc2CC[C@H](N(C3CC3)C(=O)[C@H]3CNCCO3)c2c1
Show InChI InChI=1S/C21H30N2O4/c1-25-10-2-11-26-17-7-3-15-4-8-19(18(15)13-17)23(16-5-6-16)21(24)20-14-22-9-12-27-20/h3,7,13,16,19-20,22H,2,4-6,8-12,14H2,1H3/t19-,20+/m0/s1
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n/an/a 300n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212475
PNG
(US10155731, Example 26 | US9278944, 26)
Show SMILES COCCCOc1cc(C)cc(c1)[C@H](C)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C21H32N2O4/c1-15-11-17(13-19(12-15)26-9-4-8-25-3)16(2)23(18-5-6-18)21(24)20-14-22-7-10-27-20/h11-13,16,18,20,22H,4-10,14H2,1-3H3/t16-,20+/m0/s1
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n/an/a 320n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212521
PNG
(US10155731, Example 83 | US9278944, 83)
Show SMILES COCCCn1cc(C)c2ccc(cc12)[C@H](C)N(C1CC1)C(=O)[C@H]1CNCCN1
Show InChI InChI=1S/C23H34N4O2/c1-16-15-26(11-4-12-29-3)22-13-18(5-8-20(16)22)17(2)27(19-6-7-19)23(28)21-14-24-9-10-25-21/h5,8,13,15,17,19,21,24-25H,4,6-7,9-12,14H2,1-3H3/t17-,21+/m0/s1
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n/an/a 330n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212464
PNG
(US10155731, Example 8 | US9278944, 8)
Show SMILES C[C@H](N(C1CC1)C(=O)[C@H]1CNCCO1)c1ccc2ccccc2c1
Show InChI InChI=1S/C20H24N2O2/c1-14(16-7-6-15-4-2-3-5-17(15)12-16)22(18-8-9-18)20(23)19-13-21-10-11-24-19/h2-7,12,14,18-19,21H,8-11,13H2,1H3/t14-,19+/m0/s1
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n/an/a 490n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212542
PNG
(US10155731, Example 109 | US9278944, 109)
Show SMILES COCCCOc1cc(cc2cnn(C)c12)[C@H](C)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C22H32N4O4/c1-15(26(18-5-6-18)22(27)20-14-23-7-10-30-20)16-11-17-13-24-25(2)21(17)19(12-16)29-9-4-8-28-3/h11-13,15,18,20,23H,4-10,14H2,1-3H3/t15-,20+/m0/s1
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n/an/a 500n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212541
PNG
(US10155731, Example 106 | US9278944, 106)
Show SMILES COCCCOc1cc(cc2CCOc12)[C@H](C)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C22H32N2O5/c1-15(24(18-4-5-18)22(25)20-14-23-7-11-28-20)17-12-16-6-10-29-21(16)19(13-17)27-9-3-8-26-2/h12-13,15,18,20,23H,3-11,14H2,1-2H3/t15-,20+/m0/s1
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n/an/a 530n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212544
PNG
(US10155731, Example 113 | US9278944, 113)
Show SMILES COc1cccc2CCC(Cc12)N(C1CC1)C(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C19H26N2O3/c1-23-17-4-2-3-13-5-6-15(11-16(13)17)21(14-7-8-14)19(22)18-12-20-9-10-24-18/h2-4,14-15,18,20H,5-12H2,1H3/t15?,18-/m1/s1
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n/an/a 540n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212480
PNG
(BDBM212505 | US10155731, Example 63 | US9278944, 3...)
Show SMILES COCCCn1cc(Cl)c2ccc(cc12)[C@H](C)N(C1CC1)C(=O)[C@H]1CNCCN1
Show InChI InChI=1S/C22H31ClN4O2/c1-15(27(17-5-6-17)22(28)20-13-24-8-9-25-20)16-4-7-18-19(23)14-26(21(18)12-16)10-3-11-29-2/h4,7,12,14-15,17,20,24-25H,3,5-6,8-11,13H2,1-2H3/t15-,20+/m0/s1
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n/an/a 580n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
Renin


(Homo sapiens (human))
BDBM212480
PNG
(BDBM212505 | US10155731, Example 63 | US9278944, 3...)
Show SMILES COCCCn1cc(Cl)c2ccc(cc12)[C@H](C)N(C1CC1)C(=O)[C@H]1CNCCN1
Show InChI InChI=1S/C22H31ClN4O2/c1-15(27(17-5-6-17)22(28)20-13-24-8-9-25-20)16-4-7-18-19(23)14-26(21(18)12-16)10-3-11-29-2/h4,7,12,14-15,17,20,24-25H,3,5-6,8-11,13H2,1-2H3/t15-,20+/m0/s1
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n/an/a 800n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION; SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.

US Patent


Assay Description
A substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluorophotom...


US Patent US10155731 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%