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Patent code US10155763

Compile Data Set for Download or QSAR
Found 7 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
TGF-beta receptor type I


(Homo sapiens)
BDBM311398
PNG
(US10155763, Example 6)
Show SMILES Cc1cccc(n1)-c1nc2NCCn2c1-c1cc2cnccc2s1
Show InChI InChI=1S/C18H15N5S/c1-11-3-2-4-13(21-11)16-17(23-8-7-20-18(23)22-16)15-9-12-10-19-6-5-14(12)24-15/h2-6,9-10H,7-8H2,1H3,(H,20,22)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 6.10n/an/an/an/an/an/a



TIUMBIO CO., LTD.

US Patent


Assay Description
The kinase activity of ALK5 was assessed by measuring radiolabelled phosphate[33P] incorporation into the generic substrate, casein. The kinase domai...


US Patent US10155763 (2018)

More data for this
Ligand-Target Pair
TGF-beta receptor type I


(Homo sapiens)
BDBM311395
PNG
(US10155763, Example 2)
Show SMILES Cc1cccc(n1)-c1nc2NCCn2c1-c1ccc2nccnc2c1
Show InChI InChI=1S/C19H16N6/c1-12-3-2-4-15(23-12)17-18(25-10-9-22-19(25)24-17)13-5-6-14-16(11-13)21-8-7-20-14/h2-8,11H,9-10H2,1H3,(H,22,24)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 6.60n/an/an/an/an/an/a



TIUMBIO CO., LTD.

US Patent


Assay Description
The kinase activity of ALK5 was assessed by measuring radiolabelled phosphate[33P] incorporation into the generic substrate, casein. The kinase domai...


US Patent US10155763 (2018)

More data for this
Ligand-Target Pair
TGF-beta receptor type I


(Homo sapiens)
BDBM311399
PNG
(US10155763, Example 7)
Show SMILES Cc1cccc(n1)-c1nc2NCCn2c1-c1ccc2ncsc2c1
Show InChI InChI=1S/C18H15N5S/c1-11-3-2-4-14(21-11)16-17(23-8-7-19-18(23)22-16)12-5-6-13-15(9-12)24-10-20-13/h2-6,9-10H,7-8H2,1H3,(H,19,22)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 10.3n/an/an/an/an/an/a



TIUMBIO CO., LTD.

US Patent


Assay Description
The kinase activity of ALK5 was assessed by measuring radiolabelled phosphate[33P] incorporation into the generic substrate, casein. The kinase domai...


US Patent US10155763 (2018)

More data for this
Ligand-Target Pair
TGF-beta receptor type I


(Homo sapiens)
BDBM311400
PNG
(US10155763, Example 9)
Show SMILES Cc1cccc(n1)-c1nc2NCCn2c1-c1ccc2ncnn2c1
Show InChI InChI=1S/C17H15N7/c1-11-3-2-4-13(21-11)15-16(23-8-7-18-17(23)22-15)12-5-6-14-19-10-20-24(14)9-12/h2-6,9-10H,7-8H2,1H3,(H,18,22)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 11.5n/an/an/an/an/an/a



TIUMBIO CO., LTD.

US Patent


Assay Description
The kinase activity of ALK5 was assessed by measuring radiolabelled phosphate[33P] incorporation into the generic substrate, casein. The kinase domai...


US Patent US10155763 (2018)

More data for this
Ligand-Target Pair
TGF-beta receptor type I


(Homo sapiens)
BDBM311397
PNG
(US10155763, Example 4)
Show SMILES Cc1cccc(n1)-c1nc2NCCn2c1-c1ccc2ncccc2c1
Show InChI InChI=1S/C20H17N5/c1-13-4-2-6-17(23-13)18-19(25-11-10-22-20(25)24-18)15-7-8-16-14(12-15)5-3-9-21-16/h2-9,12H,10-11H2,1H3,(H,22,24)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 12.1n/an/an/an/an/an/a



TIUMBIO CO., LTD.

US Patent


Assay Description
The kinase activity of ALK5 was assessed by measuring radiolabelled phosphate[33P] incorporation into the generic substrate, casein. The kinase domai...


US Patent US10155763 (2018)

More data for this
Ligand-Target Pair
TGF-beta receptor type I


(Homo sapiens)
BDBM311396
PNG
(US10155763, Example 3)
Show SMILES Cc1cccc(n1)-c1nc2NCCCn2c1-c1ccc2nccnc2c1
Show InChI InChI=1S/C20H18N6/c1-13-4-2-5-16(24-13)18-19(26-11-3-8-23-20(26)25-18)14-6-7-15-17(12-14)22-10-9-21-15/h2,4-7,9-10,12H,3,8,11H2,1H3,(H,23,25)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 31.6n/an/an/an/an/an/a



TIUMBIO CO., LTD.

US Patent


Assay Description
The kinase activity of ALK5 was assessed by measuring radiolabelled phosphate[33P] incorporation into the generic substrate, casein. The kinase domai...


US Patent US10155763 (2018)

More data for this
Ligand-Target Pair
TGF-beta receptor type I


(Homo sapiens)
BDBM311401
PNG
(US10155763, Example 15)
Show SMILES CN(C)CCOc1cnc2ccc(cc2n1)-c1c(nc2NCCn12)-c1cccc(C)n1
Show InChI InChI=1S/C23H25N7O/c1-15-5-4-6-18(26-15)21-22(30-10-9-24-23(30)28-21)16-7-8-17-19(13-16)27-20(14-25-17)31-12-11-29(2)3/h4-8,13-14H,9-12H2,1-3H3,(H,24,28)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 38.1n/an/an/an/an/an/a



TIUMBIO CO., LTD.

US Patent


Assay Description
The kinase activity of ALK5 was assessed by measuring radiolabelled phosphate[33P] incorporation into the generic substrate, casein. The kinase domai...


US Patent US10155763 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%