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Patent code US10155764

Compile Data Set for Download or QSAR
Found 114 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311486
PNG
(CHEM-US-00192 | US10155764, Example 65B)
Show SMILES C[C@@H](Nc1nn(C)c(=O)c2cccnc12)[C@H](N(C)C)c1ccccc1
Show InChI InChI=1S/C19H23N5O/c1-13(17(23(2)3)14-9-6-5-7-10-14)21-18-16-15(11-8-12-20-16)19(25)24(4)22-18/h5-13,17H,1-4H3,(H,21,22)/t13-,17+/m1/s1
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n/an/a 19n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311498
PNG
(CHEM-US-00210 | US10155764, Example 74A)
Show SMILES C[C@H](Nc1nn(C)c(=O)c2cccnc12)[C@@H](N(C)C)c1ccc(cc1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C25H27N5O3S/c1-17(27-24-22-21(11-8-16-26-22)25(31)30(4)28-24)23(29(2)3)18-12-14-20(15-13-18)34(32,33)19-9-6-5-7-10-19/h5-17,23H,1-4H3,(H,27,28)/t17-,23+/m0/s1
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n/an/a 20n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311480
PNG
(CHEM-US-00186 | US10155764, Example 60)
Show SMILES C[C@H](Nc1nn(C)c(=O)c2ccccc12)[C@@H](N(C)C)c1ccccn1
Show InChI InChI=1S/C19H23N5O/c1-13(17(23(2)3)16-11-7-8-12-20-16)21-18-14-9-5-6-10-15(14)19(25)24(4)22-18/h5-13,17H,1-4H3,(H,21,22)/t13-,17+/m0/s1
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n/an/a 21n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311495
PNG
(CHEM-US-00207 | US10155764, Example 73A)
Show SMILES C[C@H](Nc1nn(C)c(=O)c2ccccc12)[C@@H](N(C)C)c1ccccc1
Show InChI InChI=1S/C20H24N4O/c1-14(18(23(2)3)15-10-6-5-7-11-15)21-19-16-12-8-9-13-17(16)20(25)24(4)22-19/h5-14,18H,1-4H3,(H,21,22)/t14-,18+/m0/s1
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n/an/a 23n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311483
PNG
(CHEM-US-00189 | US10155764, Example 63)
Show SMILES C[C@H](Nc1nn(C)c(=O)c2ccccc12)[C@@H](N(C)C)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C26H28N4O2/c1-18(27-25-22-12-8-9-13-23(22)26(31)30(4)28-25)24(29(2)3)19-14-16-21(17-15-19)32-20-10-6-5-7-11-20/h5-18,24H,1-4H3,(H,27,28)/t18-,24+/m0/s1
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n/an/a 25n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311512
PNG
(CHEM-US-00232 | US10155764, Example 87)
Show SMILES C[C@H](Nc1nn(C)c(=O)c2cccnc12)[C@@H](N(C)C)c1ccc(cc1)C(=O)OCc1ccccc1
Show InChI InChI=1S/C27H29N5O3/c1-18(29-25-23-22(11-8-16-28-23)26(33)32(4)30-25)24(31(2)3)20-12-14-21(15-13-20)27(34)35-17-19-9-6-5-7-10-19/h5-16,18,24H,17H2,1-4H3,(H,29,30)/t18-,24+/m0/s1
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n/an/a 29n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311511
PNG
(US10155764, Example 86)
Show SMILES CC(C)OC(=O)c1ccc(cc1)[C@@H]([C@H](C)Nc1nn(C)c(=O)c2cccnc12)N(C)C
Show InChI InChI=1S/C23H29N5O3/c1-14(2)31-23(30)17-11-9-16(10-12-17)20(27(4)5)15(3)25-21-19-18(8-7-13-24-19)22(29)28(6)26-21/h7-15,20H,1-6H3,(H,25,26)/t15-,20+/m0/s1
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GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311479
PNG
(CHEM-US-00185 | US10155764, Example 59)
Show SMILES CC(C)Oc1ccc(cc1)[C@@H]([C@H](C)Nc1nn(C)c(=O)c2ccccc12)N(C)C
Show InChI InChI=1S/C23H30N4O2/c1-15(2)29-18-13-11-17(12-14-18)21(26(4)5)16(3)24-22-19-9-7-8-10-20(19)23(28)27(6)25-22/h7-16,21H,1-6H3,(H,24,25)/t16-,21+/m0/s1
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n/an/a 33n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311490
PNG
(CHEM-US-00202 | US10155764, Example 70A)
Show SMILES C[C@H](Nc1nn(C)c(=O)c2cccc(C)c12)[C@@H](N(C)C)c1ccccc1
Show InChI InChI=1S/C21H26N4O/c1-14-10-9-13-17-18(14)20(23-25(5)21(17)26)22-15(2)19(24(3)4)16-11-7-6-8-12-16/h6-13,15,19H,1-5H3,(H,22,23)/t15-,19+/m0/s1
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n/an/a 36n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311502
PNG
(US10155764, Example 77)
Show SMILES C[C@H](Nc1nn(C)c(=O)c2ccccc12)[C@@H](N(C)C)c1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C27H30N4O2/c1-19(28-26-23-12-8-9-13-24(23)27(32)31(4)29-26)25(30(2)3)21-14-16-22(17-15-21)33-18-20-10-6-5-7-11-20/h5-17,19,25H,18H2,1-4H3,(H,28,29)/t19-,25+/m0/s1
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n/an/a 36n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311478
PNG
(CHEM-US-00184 | US10155764, Example 58)
Show SMILES CC[C@H](Nc1nn(C)c(=O)c2cccnc12)[C@@H](N(C)C)c1ccccc1
Show InChI InChI=1S/C20H25N5O/c1-5-16(18(24(2)3)14-10-7-6-8-11-14)22-19-17-15(12-9-13-21-17)20(26)25(4)23-19/h6-13,16,18H,5H2,1-4H3,(H,22,23)/t16-,18-/m0/s1
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GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311448
PNG
(CHEM-US-00145 | US10155764, Example 34)
Show SMILES CN(C)[C@H]1CN(CC[C@@H]1Nc1nn(C)c(=O)c2ccccc12)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H26ClN5O/c1-26(2)20-14-28(16-10-8-15(23)9-11-16)13-12-19(20)24-21-17-6-4-5-7-18(17)22(29)27(3)25-21/h4-11,19-20H,12-14H2,1-3H3,(H,24,25)/t19-,20-/m0/s1
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GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311497
PNG
(CHEM-US-00209 | US10155764, Example 74)
Show SMILES CC(Nc1nn(C)c(=O)c2cccnc12)C(N(C)C)c1ccc(cc1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C25H27N5O3S/c1-17(27-24-22-21(11-8-16-26-22)25(31)30(4)28-24)23(29(2)3)18-12-14-20(15-13-18)34(32,33)19-9-6-5-7-10-19/h5-17,23H,1-4H3,(H,27,28)
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GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311476
PNG
(CHEM-US-00182 | US10155764, Example 56)
Show SMILES CC[C@H](Nc1nn(C)c(=O)c2ccccc12)[C@@H](N(C)C)c1ccccc1
Show InChI InChI=1S/C21H26N4O/c1-5-18(19(24(2)3)15-11-7-6-8-12-15)22-20-16-13-9-10-14-17(16)21(26)25(4)23-20/h6-14,18-19H,5H2,1-4H3,(H,22,23)/t18-,19-/m0/s1
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GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311412
PNG
(US10155764, Example 8A)
Show SMILES C[C@@H](CN(C)C)Nc1nn(C)c(=O)c2cccnc12
Show InChI InChI=1S/C13H19N5O/c1-9(8-17(2)3)15-12-11-10(6-5-7-14-11)13(19)18(4)16-12/h5-7,9H,8H2,1-4H3,(H,15,16)/t9-/m0/s1
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GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311501
PNG
(US10155764, Example 76)
Show SMILES C[C@H](Nc1nn(C)c(=O)c2ccccc12)[C@@H](N(C)C)c1ccc(O)cc1
Show InChI InChI=1S/C20H24N4O2/c1-13(18(23(2)3)14-9-11-15(25)12-10-14)21-19-16-7-5-6-8-17(16)20(26)24(4)22-19/h5-13,18,25H,1-4H3,(H,21,22)/t13-,18+/m0/s1
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GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311503
PNG
(CHEM-US-00222 | US10155764, Example 78)
Show SMILES C[C@H](Nc1nn(C)c(=O)c2ccccc12)[C@@H](N(C)C)c1ccc(OCC2CC2)cc1
Show InChI InChI=1S/C24H30N4O2/c1-16(25-23-20-7-5-6-8-21(20)24(29)28(4)26-23)22(27(2)3)18-11-13-19(14-12-18)30-15-17-9-10-17/h5-8,11-14,16-17,22H,9-10,15H2,1-4H3,(H,25,26)/t16-,22+/m0/s1
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GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311403
PNG
(US10155764, Example 1A)
Show SMILES CN(C)[C@H](CNc1nn(C)c(=O)c2cccnc12)c1ccccc1
Show InChI InChI=1S/C18H21N5O/c1-22(2)15(13-8-5-4-6-9-13)12-20-17-16-14(10-7-11-19-16)18(24)23(3)21-17/h4-11,15H,12H2,1-3H3,(H,20,21)/t15-/m1/s1
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GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311472
PNG
(CHEM-US-00174 | US10155764, Example 54 | US1015576...)
Show SMILES CN(C)[C@H]1CCCC[C@H]1Nc1nn(C)c(=O)c2ccccc12
Show InChI InChI=1S/C17H24N4O/c1-20(2)15-11-7-6-10-14(15)18-16-12-8-4-5-9-13(12)17(22)21(3)19-16/h4-5,8-9,14-15H,6-7,10-11H2,1-3H3,(H,18,19)/t14-,15+/m1/s1
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n/an/a 45n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311505
PNG
(CHEM-US-00224 | US10155764, Example 80)
Show SMILES C[C@H](Nc1nn(C)c(=O)c2ccccc12)[C@@H](N(C)C)c1ccc(Oc2ccccn2)cc1
Show InChI InChI=1S/C25H27N5O2/c1-17(27-24-20-9-5-6-10-21(20)25(31)30(4)28-24)23(29(2)3)18-12-14-19(15-13-18)32-22-11-7-8-16-26-22/h5-17,23H,1-4H3,(H,27,28)/t17-,23+/m0/s1
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GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311433
PNG
(CHEM-US-00130 | US10155764, Example 22A)
Show SMILES CN(C)[C@H](CNc1nn(C)c(=O)c2ccccc12)c1ccccc1
Show InChI InChI=1S/C19H22N4O/c1-22(2)17(14-9-5-4-6-10-14)13-20-18-15-11-7-8-12-16(15)19(24)23(3)21-18/h4-12,17H,13H2,1-3H3,(H,20,21)/t17-/m1/s1
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n/an/a 47n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311510
PNG
(CHEM-US-00230 | US10155764, Example 85)
Show SMILES CNC(=O)c1ccc(cc1)[C@@H]([C@H](C)Nc1nn(C)c(=O)c2cccnc12)N(C)C
Show InChI InChI=1S/C21H26N6O2/c1-13(18(26(3)4)14-8-10-15(11-9-14)20(28)22-2)24-19-17-16(7-6-12-23-17)21(29)27(5)25-19/h6-13,18H,1-5H3,(H,22,28)(H,24,25)/t13-,18+/m0/s1
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n/an/a 50n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311509
PNG
(CHEM-US-00229 | US10155764, Example 84)
Show SMILES C[C@H](Nc1nn(C)c(=O)c2cccnc12)[C@@H](N(C)C)c1ccc(cc1)C(=O)N(C)Cc1ccccc1
Show InChI InChI=1S/C28H32N6O2/c1-19(30-26-24-23(12-9-17-29-24)28(36)34(5)31-26)25(32(2)3)21-13-15-22(16-14-21)27(35)33(4)18-20-10-7-6-8-11-20/h6-17,19,25H,18H2,1-5H3,(H,30,31)/t19-,25+/m0/s1
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n/an/a 56n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311424
PNG
(US10155764, Example 16A)
Show SMILES CN(C)[C@H]1CCC[C@H]1Nc1nn(C)c(=O)c2cccnc12
Show InChI InChI=1S/C15H21N5O/c1-19(2)12-8-4-7-11(12)17-14-13-10(6-5-9-16-13)15(21)20(3)18-14/h5-6,9,11-12H,4,7-8H2,1-3H3,(H,17,18)/t11-,12+/m1/s1
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n/an/a 57n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311507
PNG
(US10155764, Example 82)
Show SMILES C[C@H](Nc1nn(C)c(=O)c2cccnc12)[C@@H](N(C)C)c1ccc(cc1)C(=O)N1CCOCC1
Show InChI InChI=1S/C24H30N6O3/c1-16(26-22-20-19(6-5-11-25-20)24(32)29(4)27-22)21(28(2)3)17-7-9-18(10-8-17)23(31)30-12-14-33-15-13-30/h5-11,16,21H,12-15H2,1-4H3,(H,26,27)/t16-,21+/m0/s1
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n/an/a 59n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311475
PNG
(US10155764, Example 55)
Show SMILES C[C@H](Nc1nn(C)c(=O)c2ccccc12)[C@@H](N(C)C)c1ccc(cc1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C26H28N4O3S/c1-18(27-25-22-12-8-9-13-23(22)26(31)30(4)28-25)24(29(2)3)19-14-16-21(17-15-19)34(32,33)20-10-6-5-7-11-20/h5-18,24H,1-4H3,(H,27,28)/t18-,24+/m0/s1
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n/an/a 61n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311482
PNG
(CHEM-US-00188 | US10155764, Example 62)
Show SMILES COc1ccc(cn1)[C@@H]([C@H](C)Nc1nn(C)c(=O)c2ccccc12)N(C)C
Show InChI InChI=1S/C20H25N5O2/c1-13(18(24(2)3)14-10-11-17(27-5)21-12-14)22-19-15-8-6-7-9-16(15)20(26)25(4)23-19/h6-13,18H,1-5H3,(H,22,23)/t13-,18+/m0/s1
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n/an/a 63n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311431
PNG
(CHEM-US-00128 | US10155764, Example 21)
Show SMILES COc1ccc(cc1)C(CNc1nn(C)c(=O)c2ccccc12)N(C)C
Show InChI InChI=1S/C20H24N4O2/c1-23(2)18(14-9-11-15(26-4)12-10-14)13-21-19-16-7-5-6-8-17(16)20(25)24(3)22-19/h5-12,18H,13H2,1-4H3,(H,21,22)
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GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311440
PNG
(CHEM-US-00137 | US10155764, Example 28)
Show SMILES CC(CN(C)C)Nc1nn(C)c(=O)c2ccccc12
Show InChI InChI=1S/C14H20N4O/c1-10(9-17(2)3)15-13-11-7-5-6-8-12(11)14(19)18(4)16-13/h5-8,10H,9H2,1-4H3,(H,15,16)
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n/an/a 66n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311444
PNG
(CHEM-US-00141 | US10155764, Example 32 | US1015576...)
Show SMILES CN(C)C1CN(CCC1Nc1nn(C)c(=O)c2cccnc12)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H25ClN6O/c1-26(2)18-13-28(15-8-6-14(22)7-9-15)12-10-17(18)24-20-19-16(5-4-11-23-19)21(29)27(3)25-20/h4-9,11,17-18H,10,12-13H2,1-3H3,(H,24,25)
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n/an/a 69n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311508
PNG
(CHEM-US-00228 | US10155764, Example 83)
Show SMILES C[C@H](Nc1nn(C)c(=O)c2cccnc12)[C@@H](N(C)C)c1ccc(cc1)C(=O)N1CCCC1
Show InChI InChI=1S/C24H30N6O2/c1-16(26-22-20-19(8-7-13-25-20)24(32)29(4)27-22)21(28(2)3)17-9-11-18(12-10-17)23(31)30-14-5-6-15-30/h7-13,16,21H,5-6,14-15H2,1-4H3,(H,26,27)/t16-,21+/m0/s1
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n/an/a 71n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311411
PNG
(US10155764, Example 7B)
Show SMILES C[C@H](CNc1nn(C)c(=O)c2cccnc12)N(C)C
Show InChI InChI=1S/C13H19N5O/c1-9(17(2)3)8-15-12-11-10(6-5-7-14-11)13(19)18(4)16-12/h5-7,9H,8H2,1-4H3,(H,15,16)/t9-/m1/s1
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GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311504
PNG
(CHEM-US-00223 | US10155764, Example 79)
Show SMILES COc1ccc(cc1)[C@@H]([C@H](C)Nc1nn(C)c(=O)c2ccccc12)N(C)C
Show InChI InChI=1S/C21H26N4O2/c1-14(19(24(2)3)15-10-12-16(27-5)13-11-15)22-20-17-8-6-7-9-18(17)21(26)25(4)23-20/h6-14,19H,1-5H3,(H,22,23)/t14-,19+/m0/s1
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n/an/a 73n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311477
PNG
(CHEM-US-00183 | US10155764, Example 57)
Show SMILES C[C@H](Nc1nn(C)c(=O)c2ccccc12)[C@@H](N(C)C)c1cnn(c1)-c1ccccc1
Show InChI InChI=1S/C23H26N6O/c1-16(25-22-19-12-8-9-13-20(19)23(30)28(4)26-22)21(27(2)3)17-14-24-29(15-17)18-10-6-5-7-11-18/h5-16,21H,1-4H3,(H,25,26)/t16-,21+/m0/s1
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n/an/a 75n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311422
PNG
(US10155764, Example 15A)
Show SMILES CN(C)[C@H]1CCCC[C@H]1Nc1nn(C)c(=O)c2cccnc12
Show InChI InChI=1S/C16H23N5O/c1-20(2)13-9-5-4-8-12(13)18-15-14-11(7-6-10-17-14)16(22)21(3)19-15/h6-7,10,12-13H,4-5,8-9H2,1-3H3,(H,18,19)/t12-,13+/m1/s1
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n/an/a 78n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311513
PNG
(US10155764, Example 88)
Show SMILES C[C@H](Nc1nn(C)c(=O)c2ccccc12)[C@@H](N(C)C)c1ccc(=O)[nH]c1
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n/an/a 80n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311493
PNG
(CHEM-US-00205 | US10155764, Example 71B)
Show SMILES C[C@@H](Nc1nn(C)c(=O)c2[nH]ccc12)[C@H](N(C)C)c1ccccc1
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GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311402
PNG
(US10155764, Example 1)
Show SMILES CN(C)C(CNc1nn(C)c(=O)c2cccnc12)c1ccccc1
Show InChI InChI=1S/C18H21N5O/c1-22(2)15(13-8-5-4-6-9-13)12-20-17-16-14(10-7-11-19-16)18(24)23(3)21-17/h4-11,15H,12H2,1-3H3,(H,20,21)
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GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311481
PNG
(CHEM-US-00187 | US10155764, Example 61)
Show SMILES C[C@H](Nc1nn(C)c(=O)c2ccccc12)[C@@H](N(C)C)c1cccnc1
Show InChI InChI=1S/C19H23N5O/c1-13(17(23(2)3)14-8-7-11-20-12-14)21-18-15-9-5-6-10-16(15)19(25)24(4)22-18/h5-13,17H,1-4H3,(H,21,22)/t13-,17+/m0/s1
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GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311409
PNG
(US10155764, Example 6)
Show SMILES CN(C)CCNc1nn(C)c(=O)c2c(F)cccc12
Show InChI InChI=1S/C13H17FN4O/c1-17(2)8-7-15-12-9-5-4-6-10(14)11(9)13(19)18(3)16-12/h4-6H,7-8H2,1-3H3,(H,15,16)
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n/an/a 87n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311455
PNG
(CHEM-US-00152 | US10155764, Example 39B)
Show SMILES CC[C@H](CNc1nn(C)c(=O)c2ccccc12)N(C)C
Show InChI InChI=1S/C15H22N4O/c1-5-11(18(2)3)10-16-14-12-8-6-7-9-13(12)15(20)19(4)17-14/h6-9,11H,5,10H2,1-4H3,(H,16,17)/t11-/m1/s1
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n/an/a 89n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311506
PNG
(US10155764, Example 81)
Show SMILES C[C@H](Nc1nn(C)c(=O)c2cccnc12)[C@@H](N(C)C)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C20H23N5O3/c1-12(17(24(2)3)13-7-9-14(10-8-13)20(27)28)22-18-16-15(6-5-11-21-16)19(26)25(4)23-18/h5-12,17H,1-4H3,(H,22,23)(H,27,28)/t12-,17+/m0/s1
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n/an/a 98n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311494
PNG
(CHEM-US-00206 | US10155764, Example 72)
Show SMILES C[C@H](Nc1nn(C)c(=O)c2cccnc12)[C@@H](N(C)C)c1cccc(NC(C)=O)c1
Show InChI InChI=1S/C21H26N6O2/c1-13(19(26(3)4)15-8-6-9-16(12-15)24-14(2)28)23-20-18-17(10-7-11-22-18)21(29)27(5)25-20/h6-13,19H,1-5H3,(H,23,25)(H,24,28)/t13-,19+/m0/s1
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n/an/a 99n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311430
PNG
(US10155764, Example 20)
Show SMILES CN(C)C(CNc1nn(C)c(=O)c2ccccc12)c1ccc(F)cc1
Show InChI InChI=1S/C19H21FN4O/c1-23(2)17(13-8-10-14(20)11-9-13)12-21-18-15-6-4-5-7-16(15)19(25)24(3)22-18/h4-11,17H,12H2,1-3H3,(H,21,22)
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n/an/a 110n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311437
PNG
(CHEM-US-00134 | US10155764, Example 25)
Show SMILES CN(C)C(CNc1nn(C)c(=O)c2ccccc12)c1ccccc1Cl
Show InChI InChI=1S/C19H21ClN4O/c1-23(2)17(15-10-6-7-11-16(15)20)12-21-18-13-8-4-5-9-14(13)19(25)24(3)22-18/h4-11,17H,12H2,1-3H3,(H,21,22)
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n/an/a 110n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311472
PNG
(CHEM-US-00174 | US10155764, Example 54 | US1015576...)
Show SMILES CN(C)[C@H]1CCCC[C@H]1Nc1nn(C)c(=O)c2ccccc12
Show InChI InChI=1S/C17H24N4O/c1-20(2)15-11-7-6-10-14(15)18-16-12-8-4-5-9-13(12)17(22)21(3)19-16/h4-5,8-9,14-15H,6-7,10-11H2,1-3H3,(H,18,19)/t14-,15+/m1/s1
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n/an/a 110n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311438
PNG
(CHEM-US-00135 | US10155764, Example 26)
Show SMILES CN(C)C(CNc1nn(C)c(=O)c2ccccc12)c1ccccc1F
Show InChI InChI=1S/C19H21FN4O/c1-23(2)17(15-10-6-7-11-16(15)20)12-21-18-13-8-4-5-9-14(13)19(25)24(3)22-18/h4-11,17H,12H2,1-3H3,(H,21,22)
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GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311439
PNG
(CHEM-US-00136 | US10155764, Example 27)
Show SMILES CN(C)C(CNc1nn(C)c(=O)c2ccccc12)c1ccc(Cl)cc1
Show InChI InChI=1S/C19H21ClN4O/c1-23(2)17(13-8-10-14(20)11-9-13)12-21-18-15-6-4-5-7-16(15)19(25)24(3)22-18/h4-11,17H,12H2,1-3H3,(H,21,22)
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n/an/a 120n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311500
PNG
(CHEM-US-00212 | US10155764, Example 75)
Show SMILES CC(Nc1nn(C)c(=O)c2cccnc12)C(N(C)C)c1cn(C)nn1
Show InChI InChI=1S/C16H22N8O/c1-10(14(22(2)3)12-9-23(4)21-19-12)18-15-13-11(7-6-8-17-13)16(25)24(5)20-15/h6-10,14H,1-5H3,(H,18,20)
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n/an/a 130n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311408
PNG
(US10155764, Example 5)
Show SMILES CN(C)CCNc1nn(C)c(=O)c2cccc(F)c12
Show InChI InChI=1S/C13H17FN4O/c1-17(2)8-7-15-12-11-9(5-4-6-10(11)14)13(19)18(3)16-12/h4-6H,7-8H2,1-3H3,(H,15,16)
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n/an/a 130n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311451
PNG
(CHEM-US-00148 | US10155764, Example 37)
Show SMILES CN(C)C(CNc1nn(C)c(=O)c2CCCc12)c1ccccc1
Show InChI InChI=1S/C18H24N4O/c1-21(2)16(13-8-5-4-6-9-13)12-19-17-14-10-7-11-15(14)18(23)22(3)20-17/h4-6,8-9,16H,7,10-12H2,1-3H3,(H,19,20)
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n/an/a 130n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311432
PNG
(CHEM-US-00129 | US10155764, Example 22)
Show SMILES CN(C)C(CNc1nn(C)c(=O)c2ccccc12)c1ccccc1
Show InChI InChI=1S/C19H22N4O/c1-22(2)17(14-9-5-4-6-10-14)13-20-18-15-11-7-8-12-16(15)19(24)23(3)21-18/h4-12,17H,13H2,1-3H3,(H,20,21)
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n/an/a 140n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311444
PNG
(CHEM-US-00141 | US10155764, Example 32 | US1015576...)
Show SMILES CN(C)C1CN(CCC1Nc1nn(C)c(=O)c2cccnc12)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H25ClN6O/c1-26(2)18-13-28(15-8-6-14(22)7-9-15)12-10-17(18)24-20-19-16(5-4-11-23-19)21(29)27(3)25-20/h4-9,11,17-18H,10,12-13H2,1-3H3,(H,24,25)
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n/an/a 140n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311405
PNG
(US10155764, Example 2)
Show SMILES CN(C)CCNc1nn(C)c(=O)c2cccnc12
Show InChI InChI=1S/C12H17N5O/c1-16(2)8-7-14-11-10-9(5-4-6-13-10)12(18)17(3)15-11/h4-6H,7-8H2,1-3H3,(H,14,15)
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n/an/a 140n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311444
PNG
(CHEM-US-00141 | US10155764, Example 32 | US1015576...)
Show SMILES CN(C)C1CN(CCC1Nc1nn(C)c(=O)c2cccnc12)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H25ClN6O/c1-26(2)18-13-28(15-8-6-14(22)7-9-15)12-10-17(18)24-20-19-16(5-4-11-23-19)21(29)27(3)25-20/h4-9,11,17-18H,10,12-13H2,1-3H3,(H,24,25)
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GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311441
PNG
(CHEM-US-00138 | US10155764, Example 29)
Show SMILES CN(C)CCNc1nn(C)c(=O)c2ccccc12
Show InChI InChI=1S/C13H18N4O/c1-16(2)9-8-14-12-10-6-4-5-7-11(10)13(18)17(3)15-12/h4-7H,8-9H2,1-3H3,(H,14,15)
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n/an/a 150n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311419
PNG
(US10155764, Example 13)
Show SMILES CC(CN(C)C)Nc1nn(C)c(=O)c2cnccc12
Show InChI InChI=1S/C13H19N5O/c1-9(8-17(2)3)15-12-10-5-6-14-7-11(10)13(19)18(4)16-12/h5-7,9H,8H2,1-4H3,(H,15,16)
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GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311487
PNG
(US10155764, Example 68)
Show SMILES COC(=O)c1ccc(cc1)[C@@H]([C@H](C)Nc1nn(C)c(=O)c2cccnc12)N(C)C
Show InChI InChI=1S/C21H25N5O3/c1-13(18(25(2)3)14-8-10-15(11-9-14)21(28)29-5)23-19-17-16(7-6-12-22-17)20(27)26(4)24-19/h6-13,18H,1-5H3,(H,23,24)/t13-,18+/m0/s1
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n/an/a 160n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311489
PNG
(CHEM-US-00201 | US10155764, Example 69B)
Show SMILES C[C@@H](Nc1nn(C)c(=O)c2c(C)cccc12)[C@H](N(C)C)c1ccccc1
Show InChI InChI=1S/C21H26N4O/c1-14-10-9-13-17-18(14)21(26)25(5)23-20(17)22-15(2)19(24(3)4)16-11-7-6-8-12-16/h6-13,15,19H,1-5H3,(H,22,23)/t15-,19+/m1/s1
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n/an/a 170n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311447
PNG
(CHEM-US-00144 | US10155764, Example 33)
Show SMILES CN(C)[C@H]1CN(CC[C@H]1Nc1nn(C)c(=O)c2ccccc12)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H26ClN5O/c1-26(2)20-14-28(16-10-8-15(23)9-11-16)13-12-19(20)24-21-17-6-4-5-7-18(17)22(29)27(3)25-21/h4-11,19-20H,12-14H2,1-3H3,(H,24,25)/t19-,20+/m1/s1
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n/an/a 170n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311416
PNG
(US10155764, Example 11A)
Show SMILES CN(C)[C@@H]1CCCC[C@H]1Nc1nn(C)c(=O)c2cccnc12
Show InChI InChI=1S/C16H23N5O/c1-20(2)13-9-5-4-8-12(13)18-15-14-11(7-6-10-17-14)16(22)21(3)19-15/h6-7,10,12-13H,4-5,8-9H2,1-3H3,(H,18,19)/t12-,13-/m1/s1
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n/an/a 180n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311453
PNG
(CHEM-US-00150 | US10155764, Example 39)
Show SMILES CCC(CNc1nn(C)c(=O)c2ccccc12)N(C)C
Show InChI InChI=1S/C15H22N4O/c1-5-11(18(2)3)10-16-14-12-8-6-7-9-13(12)15(20)19(4)17-14/h6-9,11H,5,10H2,1-4H3,(H,16,17)
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GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311418
PNG
(US10155764, Example 12)
Show SMILES CC(CN(C)C)Nc1nn(C)c(=O)c2ccncc12
Show InChI InChI=1S/C13H19N5O/c1-9(8-17(2)3)15-12-11-7-14-6-5-10(11)13(19)18(4)16-12/h5-7,9H,8H2,1-4H3,(H,15,16)
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n/an/a 220n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311415
PNG
(US10155764, Example 10)
Show SMILES CN(C)C(CNc1nn(C)c(=O)c2[nH]ccc12)c1ccccc1
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n/an/a 240n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311460
PNG
(CHEM-US-00157 | US10155764, Example 44)
Show SMILES CN1CCC(C1)Nc1nn(C)c(=O)c2ccccc12
Show InChI InChI=1S/C14H18N4O/c1-17-8-7-10(9-17)15-13-11-5-3-4-6-12(11)14(19)18(2)16-13/h3-6,10H,7-9H2,1-2H3,(H,15,16)
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n/an/a 260n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311427
PNG
(US10155764, Example 17B)
Show SMILES CCn1nc(N[C@@H](C)CN(C)C)c2ccccc2c1=O
Show InChI InChI=1S/C15H22N4O/c1-5-19-15(20)13-9-7-6-8-12(13)14(17-19)16-11(2)10-18(3)4/h6-9,11H,5,10H2,1-4H3,(H,16,17)/t11-/m0/s1
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US Patent
n/an/a 280n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311484
PNG
(CHEM-US-00190 | US10155764, Example 64)
Show SMILES C[C@H](Nc1nn(C)c(=O)c2cccnc12)[C@@H](N(C)C)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C25H27N5O2/c1-17(27-24-22-21(11-8-16-26-22)25(31)30(4)28-24)23(29(2)3)18-12-14-20(15-13-18)32-19-9-6-5-7-10-19/h5-17,23H,1-4H3,(H,27,28)/t17-,23+/m0/s1
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n/an/a 290n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311406
PNG
(US10155764, Example 3)
Show SMILES COc1ccc2c(c1)c(NCCN(C)C)nn(C)c2=O
Show InChI InChI=1S/C14H20N4O2/c1-17(2)8-7-15-13-12-9-10(20-4)5-6-11(12)14(19)18(3)16-13/h5-6,9H,7-8H2,1-4H3,(H,15,16)
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n/an/a 410n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311466
PNG
(CHEM-US-00163 | US10155764, Example 48)
Show SMILES CN(C)CCOc1nn(C)c(=O)c2ccccc12
Show InChI InChI=1S/C13H17N3O2/c1-15(2)8-9-18-12-10-6-4-5-7-11(10)13(17)16(3)14-12/h4-7H,8-9H2,1-3H3
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n/an/a 450n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311407
PNG
(US10155764, Example 4)
Show SMILES COc1ccc2c(NCCN(C)C)nn(C)c(=O)c2c1
Show InChI InChI=1S/C14H20N4O2/c1-17(2)8-7-15-13-11-6-5-10(20-4)9-12(11)14(19)18(3)16-13/h5-6,9H,7-8H2,1-4H3,(H,15,16)
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US Patent
n/an/a 470n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311454
PNG
(CHEM-US-00151 | US10155764, Example 39A)
Show SMILES CC[C@@H](CNc1nn(C)c(=O)c2ccccc12)N(C)C
Show InChI InChI=1S/C15H22N4O/c1-5-11(18(2)3)10-16-14-12-8-6-7-9-13(12)15(20)19(4)17-14/h6-9,11H,5,10H2,1-4H3,(H,16,17)/t11-/m0/s1
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n/an/a 550n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311434
PNG
(CHEM-US-00131 | US10155764, Example 22B)
Show SMILES CN(C)[C@@H](CNc1nn(C)c(=O)c2ccccc12)c1ccccc1
Show InChI InChI=1S/C19H22N4O/c1-22(2)17(14-9-5-4-6-10-14)13-20-18-15-11-7-8-12-16(15)19(24)23(3)21-18/h4-12,17H,13H2,1-3H3,(H,20,21)/t17-/m0/s1
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n/an/a 550n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311496
PNG
(CHEM-US-00208 | US10155764, Example 73B)
Show SMILES C[C@@H](Nc1nn(C)c(=O)c2ccccc12)[C@H](N(C)C)c1ccccc1
Show InChI InChI=1S/C20H24N4O/c1-14(18(23(2)3)15-10-6-5-7-11-15)21-19-16-12-8-9-13-17(16)20(25)24(4)22-19/h5-14,18H,1-4H3,(H,21,22)/t14-,18+/m1/s1
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n/an/a 680n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311452
PNG
(CHEM-US-00149 | US10155764, Example 38)
Show SMILES CN(C)C(CNc1nn(C)c(=O)c2ccccc12)C1CCCCC1
Show InChI InChI=1S/C19H28N4O/c1-22(2)17(14-9-5-4-6-10-14)13-20-18-15-11-7-8-12-16(15)19(24)23(3)21-18/h7-8,11-12,14,17H,4-6,9-10,13H2,1-3H3,(H,20,21)
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n/an/a 700n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311459
PNG
(CHEM-US-00156 | US10155764, Example 43)
Show SMILES CN1CCCC(C1)Nc1nn(C)c(=O)c2ccccc12
Show InChI InChI=1S/C15H20N4O/c1-18-9-5-6-11(10-18)16-14-12-7-3-4-8-13(12)15(20)19(2)17-14/h3-4,7-8,11H,5-6,9-10H2,1-2H3,(H,16,17)
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n/an/a 790n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311469
PNG
(CHEM-US-00169 | US10155764, Example 51)
Show SMILES CN(CCNc1nn(C)c(=O)c2ccccc12)C1COC1
Show InChI InChI=1S/C15H20N4O2/c1-18(11-9-21-10-11)8-7-16-14-12-5-3-4-6-13(12)15(20)19(2)17-14/h3-6,11H,7-10H2,1-2H3,(H,16,17)
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n/an/a 800n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311470
PNG
(US10155764, Example 52)
Show SMILES CN(C)[C@@H]1CCCC[C@H]1Nc1nn(C)c(=O)c2ccccc12
Show InChI InChI=1S/C17H24N4O/c1-20(2)15-11-7-6-10-14(15)18-16-12-8-4-5-9-13(12)17(22)21(3)19-16/h4-5,8-9,14-15H,6-7,10-11H2,1-3H3,(H,18,19)/t14-,15-/m1/s1
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n/an/a 820n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311450
PNG
(CHEM-US-00147 | US10155764, Example 36)
Show SMILES CN(C)C(CNc1nn(C)c(=O)c2CCCCc12)c1ccccc1
Show InChI InChI=1S/C19H26N4O/c1-22(2)17(14-9-5-4-6-10-14)13-20-18-15-11-7-8-12-16(15)19(24)23(3)21-18/h4-6,9-10,17H,7-8,11-13H2,1-3H3,(H,20,21)
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n/an/a 820n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311515
PNG
(US10155764, Example 90)
Show SMILES CC(CN(C)C)Nc1nn(C)c(=O)c2CCN(Cc12)c1ccc(Cl)cc1
Show InChI InChI=1S/C19H26ClN5O/c1-13(11-23(2)3)21-18-17-12-25(15-7-5-14(20)6-8-15)10-9-16(17)19(26)24(4)22-18/h5-8,13H,9-12H2,1-4H3,(H,21,22)
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n/an/a 820n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311425
PNG
(US10155764, Example 16B)
Show SMILES CN(C)[C@@H]1CCC[C@@H]1Nc1nn(C)c(=O)c2cccnc12
Show InChI InChI=1S/C15H21N5O/c1-19(2)12-8-4-7-11(12)17-14-13-10(6-5-9-16-13)15(21)20(3)18-14/h5-6,9,11-12H,4,7-8H2,1-3H3,(H,17,18)/t11-,12+/m0/s1
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n/an/a 860n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311410
PNG
(US10155764, Example 7A)
Show SMILES C[C@@H](CNc1nn(C)c(=O)c2cccnc12)N(C)C
Show InChI InChI=1S/C13H19N5O/c1-9(17(2)3)8-15-12-11-10(6-5-7-14-11)13(19)18(4)16-12/h5-7,9H,8H2,1-4H3,(H,15,16)/t9-/m0/s1
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GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311414
PNG
(US10155764, Example 9)
Show SMILES CN(C)CCSc1nn(C)c(=O)c2ccccc12
Show InChI InChI=1S/C13H17N3OS/c1-15(2)8-9-18-12-10-6-4-5-7-11(10)13(17)16(3)14-12/h4-7H,8-9H2,1-3H3
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GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311436
PNG
(CHEM-US-00133 | US10155764, Example 24)
Show SMILES Cn1nc(NCCN2CCCC2)c2ccccc2c1=O
Show InChI InChI=1S/C15H20N4O/c1-18-15(20)13-7-3-2-6-12(13)14(17-18)16-8-11-19-9-4-5-10-19/h2-3,6-7H,4-5,8-11H2,1H3,(H,16,17)
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GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311468
PNG
(CHEM-US-00168 | US10155764, Example 50)
Show SMILES Cn1nc(NCCN2CCC2)c2ccccc2c1=O
Show InChI InChI=1S/C14H18N4O/c1-17-14(19)12-6-3-2-5-11(12)13(16-17)15-7-10-18-8-4-9-18/h2-3,5-6H,4,7-10H2,1H3,(H,15,16)
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GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311461
PNG
(CHEM-US-00158 | US10155764, Example 45)
Show SMILES CN1CCCCC(C1)Nc1nn(C)c(=O)c2ccccc12
Show InChI InChI=1S/C16H22N4O/c1-19-10-6-5-7-12(11-19)17-15-13-8-3-4-9-14(13)16(21)20(2)18-15/h3-4,8-9,12H,5-7,10-11H2,1-2H3,(H,17,18)
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n/an/a 1.20E+3n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311514
PNG
(US10155764, Example 89)
Show SMILES CC(CN(C)C)Nc1nn(C)c(=O)c2CN(CCc12)c1ccc(Cl)cc1
Show InChI InChI=1S/C19H26ClN5O/c1-13(11-23(2)3)21-18-16-9-10-25(15-7-5-14(20)6-8-15)12-17(16)19(26)24(4)22-18/h5-8,13H,9-12H2,1-4H3,(H,21,22)
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GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311428
PNG
(US10155764, Example 18)
Show SMILES CN1CC(C1)Nc1nn(C)c(=O)c2cccnc12
Show InChI InChI=1S/C12H15N5O/c1-16-6-8(7-16)14-11-10-9(4-3-5-13-10)12(18)17(2)15-11/h3-5,8H,6-7H2,1-2H3,(H,14,15)
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GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311423
PNG
(US10155764, Example 15B)
Show SMILES CN(C)[C@@H]1CCCC[C@@H]1Nc1nn(C)c(=O)c2cccnc12
Show InChI InChI=1S/C16H23N5O/c1-20(2)13-9-5-4-8-12(13)18-15-14-11(7-6-10-17-14)16(22)21(3)19-15/h6-7,10,12-13H,4-5,8-9H2,1-3H3,(H,18,19)/t12-,13+/m0/s1
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GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311421
PNG
(US10155764, Example 14B)
Show SMILES Cn1nc(N[C@H]2CCCC[C@H]2N)c2ncccc2c1=O
Show InChI InChI=1S/C14H19N5O/c1-19-14(20)9-5-4-8-16-12(9)13(18-19)17-11-7-3-2-6-10(11)15/h4-5,8,10-11H,2-3,6-7,15H2,1H3,(H,17,18)/t10-,11+/m1/s1
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GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311442
PNG
(CHEM-US-00139 | US10155764, Example 30)
Show SMILES CN1CCCC1CNc1nn(C)c(=O)c2ccccc12
Show InChI InChI=1S/C15H20N4O/c1-18-9-5-6-11(18)10-16-14-12-7-3-4-8-13(12)15(20)19(2)17-14/h3-4,7-8,11H,5-6,9-10H2,1-2H3,(H,16,17)
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n/an/a 1.70E+3n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311491
PNG
(CHEM-US-00203 | US10155764, Example 70B)
Show SMILES C[C@@H](Nc1nn(C)c(=O)c2cccc(C)c12)[C@H](N(C)C)c1ccccc1
Show InChI InChI=1S/C21H26N4O/c1-14-10-9-13-17-18(14)20(23-25(5)21(17)26)22-15(2)19(24(3)4)16-11-7-6-8-12-16/h6-13,15,19H,1-5H3,(H,22,23)/t15-,19+/m1/s1
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GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311485
PNG
(CHEM-US-00191 | US10155764, Example 65A)
Show SMILES C[C@H](Nc1nn(C)c(=O)c2cccnc12)[C@@H](N(C)C)c1ccccc1
Show InChI InChI=1S/C19H23N5O/c1-13(17(23(2)3)14-9-6-5-7-10-14)21-18-16-15(11-8-12-20-16)19(25)24(4)22-18/h5-13,17H,1-4H3,(H,21,22)/t13-,17+/m0/s1
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n/an/a 1.90E+3n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311471
PNG
(CHEM-US-00173 | US10155764, Example 53)
Show SMILES CN(C)[C@@H]1CCC[C@H]1Nc1nn(C)c(=O)c2ccccc12
Show InChI InChI=1S/C16H22N4O/c1-19(2)14-10-6-9-13(14)17-15-11-7-4-5-8-12(11)16(21)20(3)18-15/h4-5,7-8,13-14H,6,9-10H2,1-3H3,(H,17,18)/t13-,14-/m1/s1
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n/an/a 2.10E+3n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311457
PNG
(CHEM-US-00154 | US10155764, Example 41)
Show SMILES Cn1nc(NCCN2CCCCC2)c2ccccc2c1=O
Show InChI InChI=1S/C16H22N4O/c1-19-16(21)14-8-4-3-7-13(14)15(18-19)17-9-12-20-10-5-2-6-11-20/h3-4,7-8H,2,5-6,9-12H2,1H3,(H,17,18)
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GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311404
PNG
(US10155764, Example 1B)
Show SMILES CN(C)[C@@H](CNc1nn(C)c(=O)c2cccnc12)c1ccccc1
Show InChI InChI=1S/C18H21N5O/c1-22(2)15(13-8-5-4-6-9-13)12-20-17-16-14(10-7-11-19-16)18(24)23(3)21-17/h4-11,15H,12H2,1-3H3,(H,20,21)/t15-/m0/s1
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GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311499
PNG
(CHEM-US-00211 | US10155764, Example 74B)
Show SMILES C[C@@H](Nc1nn(C)c(=O)c2cccnc12)[C@H](N(C)C)c1ccc(cc1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C25H27N5O3S/c1-17(27-24-22-21(11-8-16-26-22)25(31)30(4)28-24)23(29(2)3)18-12-14-20(15-13-18)34(32,33)19-9-6-5-7-10-19/h5-17,23H,1-4H3,(H,27,28)/t17-,23+/m1/s1
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n/an/a 2.30E+3n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311435
PNG
(CHEM-US-00132 | US10155764, Example 23)
Show SMILES CCN(CC)CCNc1nn(C)c(=O)c2ccccc12
Show InChI InChI=1S/C15H22N4O/c1-4-19(5-2)11-10-16-14-12-8-6-7-9-13(12)15(20)18(3)17-14/h6-9H,4-5,10-11H2,1-3H3,(H,16,17)
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GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311464
PNG
(CHEM-US-00161 | US10155764, Example 47A)
Show SMILES CN(C)[C@H]1[C@H](Cc2ccccc12)Nc1nn(C)c(=O)c2ccccc12
Show InChI InChI=1S/C20H22N4O/c1-23(2)18-14-9-5-4-8-13(14)12-17(18)21-19-15-10-6-7-11-16(15)20(25)24(3)22-19/h4-11,17-18H,12H2,1-3H3,(H,21,22)/t17-,18+/m0/s1
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GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311429
PNG
(US10155764, Example 19)
Show SMILES Cn1nc(NC2CNC2)c2ncccc2c1=O
Show InChI InChI=1S/C11H13N5O/c1-16-11(17)8-3-2-4-13-9(8)10(15-16)14-7-5-12-6-7/h2-4,7,12H,5-6H2,1H3,(H,14,15)
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n/an/a 3.40E+3n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311467
PNG
(US10155764, Example 49)
Show SMILES COCCN(C)CCNc1nn(C)c(=O)c2ccccc12
Show InChI InChI=1S/C15H22N4O2/c1-18(10-11-21-3)9-8-16-14-12-6-4-5-7-13(12)15(20)19(2)17-14/h4-7H,8-11H2,1-3H3,(H,16,17)
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GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311462
PNG
(CHEM-US-00159 | US10155764, Example 46A)
Show SMILES CN(C)[C@H]1[C@H](Cc2ccccc12)Nc1nn(C)c(=O)c2cccnc12
Show InChI InChI=1S/C19H21N5O/c1-23(2)17-13-8-5-4-7-12(13)11-15(17)21-18-16-14(9-6-10-20-16)19(25)24(3)22-18/h4-10,15,17H,11H2,1-3H3,(H,21,22)/t15-,17+/m0/s1
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n/an/a 4.80E+3n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311420
PNG
(US10155764, Example 14A)
Show SMILES Cn1nc(N[C@@H]2CCCC[C@@H]2N)c2ncccc2c1=O
Show InChI InChI=1S/C14H19N5O/c1-19-14(20)9-5-4-8-16-12(9)13(18-19)17-11-7-3-2-6-10(11)15/h4-5,8,10-11H,2-3,6-7,15H2,1H3,(H,17,18)/t10-,11+/m0/s1
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GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311413
PNG
(US10155764, Example 8B)
Show SMILES C[C@H](CN(C)C)Nc1nn(C)c(=O)c2cccnc12
Show InChI InChI=1S/C13H19N5O/c1-9(8-17(2)3)15-12-11-10(6-5-7-14-11)13(19)18(4)16-12/h5-7,9H,8H2,1-4H3,(H,15,16)/t9-/m1/s1
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GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311488
PNG
(CHEM-US-00200 | US10155764, Example 69A)
Show SMILES C[C@H](Nc1nn(C)c(=O)c2c(C)cccc12)[C@@H](N(C)C)c1ccccc1
Show InChI InChI=1S/C21H26N4O/c1-14-10-9-13-17-18(14)21(26)25(5)23-20(17)22-15(2)19(24(3)4)16-11-7-6-8-12-16/h6-13,15,19H,1-5H3,(H,22,23)/t15-,19+/m0/s1
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GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311463
PNG
(CHEM-US-00160 | US10155764, Example 46B)
Show SMILES CN(C)[C@@H]1[C@@H](Cc2ccccc12)Nc1nn(C)c(=O)c2cccnc12
Show InChI InChI=1S/C19H21N5O/c1-23(2)17-13-8-5-4-7-12(13)11-15(17)21-18-16-14(9-6-10-20-16)19(25)24(3)22-18/h4-10,15,17H,11H2,1-3H3,(H,21,22)/t15-,17+/m1/s1
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GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311492
PNG
(CHEM-US-00204 | US10155764, Example 71A)
Show SMILES C[C@H](Nc1nn(C)c(=O)c2[nH]ccc12)[C@@H](N(C)C)c1ccccc1
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GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311426
PNG
(US10155764, Example 17A)
Show SMILES CCn1nc(N[C@H](C)CN(C)C)c2ccccc2c1=O
Show InChI InChI=1S/C15H22N4O/c1-5-19-15(20)13-9-7-6-8-12(13)14(17-19)16-11(2)10-18(3)4/h6-9,11H,5,10H2,1-4H3,(H,16,17)/t11-/m1/s1
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n/an/a>5.00E+3n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311465
PNG
(CHEM-US-00162 | US10155764, Example 47B)
Show SMILES CN(C)[C@@H]1[C@@H](Cc2ccccc12)Nc1nn(C)c(=O)c2ccccc12
Show InChI InChI=1S/C20H22N4O/c1-23(2)18-14-9-5-4-8-13(14)12-17(18)21-19-15-10-6-7-11-16(15)20(25)24(3)22-19/h4-11,17-18H,12H2,1-3H3,(H,21,22)/t17-,18+/m1/s1
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n/an/a>5.00E+3n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311417
PNG
(US10155764, Example 11B)
Show SMILES CN(C)[C@H]1CCCC[C@@H]1Nc1nn(C)c(=O)c2cccnc12
Show InChI InChI=1S/C16H23N5O/c1-20(2)13-9-5-4-8-12(13)18-15-14-11(7-6-10-17-14)16(22)21(3)19-15/h6-7,10,12-13H,4-5,8-9H2,1-3H3,(H,18,19)/t12-,13-/m0/s1
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n/an/a>5.00E+3n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311443
PNG
(CHEM-US-00140 | US10155764, Example 31)
Show SMILES C\C=C\Cn1nc(NC(C)CN(C)C)c2ccccc2c1=O
Show InChI InChI=1S/C17H24N4O/c1-5-6-11-21-17(22)15-10-8-7-9-14(15)16(19-21)18-13(2)12-20(3)4/h5-10,13H,11-12H2,1-4H3,(H,18,19)/b6-5+
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n/an/a 8.10E+3n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311456
PNG
(CHEM-US-00153 | US10155764, Example 40)
Show SMILES CC(C)NCCNc1nn(C)c(=O)c2ccccc12
Show InChI InChI=1S/C14H20N4O/c1-10(2)15-8-9-16-13-11-6-4-5-7-12(11)14(19)18(3)17-13/h4-7,10,15H,8-9H2,1-3H3,(H,16,17)
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n/an/a 9.40E+3n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311458
PNG
(CHEM-US-00155 | US10155764, Example 42)
Show SMILES CN1CCN(CCNc2nn(C)c(=O)c3ccccc23)CC1
Show InChI InChI=1S/C16H23N5O/c1-19-9-11-21(12-10-19)8-7-17-15-13-5-3-4-6-14(13)16(22)20(2)18-15/h3-6H,7-12H2,1-2H3,(H,17,18)
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n/an/a 9.60E+3n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311474
PNG
(CHEM-US-00176 | US10155764, Example 54B)
Show SMILES CN(C)[C@@H]1CCCC[C@@H]1Nc1nn(C)c(=O)c2ccccc12
Show InChI InChI=1S/C17H24N4O/c1-20(2)15-11-7-6-10-14(15)18-16-12-8-4-5-9-13(12)17(22)21(3)19-16/h4-5,8-9,14-15H,6-7,10-11H2,1-3H3,(H,18,19)/t14-,15+/m0/s1
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n/an/a 1.10E+4n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
PCAF (aa 719-832)


(Homo sapiens (human))
BDBM311449
PNG
(CHEM-US-00146 | US10155764, Example 35)
Show SMILES Cn1nc(N[C@@H]2CCCC[C@H]2N)c2ccccc2c1=O
Show InChI InChI=1S/C15H20N4O/c1-19-15(20)11-7-3-2-6-10(11)14(18-19)17-13-9-5-4-8-12(13)16/h2-3,6-7,12-13H,4-5,8-9,16H2,1H3,(H,17,18)/t12-,13-/m1/s1
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n/an/a 1.20E+4n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...


US Patent US10155764 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%