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Patent code US10155769

Compile Data Set for Download or QSAR
Found 91 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311805
PNG
(7-(4-Fluorophenyl)-8-(7-chloro-1H-indazol-5-yl)-2-...)
Show SMILES Fc1ccc(cc1)-c1ccn2nc(nc2c1-c1cc(Cl)c2[nH]ncc2c1)C(F)(F)F
PDB

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UniChem
US Patent
n/an/a 0.0100n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311771
PNG
(2-Cyclopentyl-7-(4-fluorophenyl)-8-(7-methyl-1H-in...)
Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(ccn2nc(nc12)C1CCCC1)-c1ccc(F)cc1
PDB

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US Patent
n/an/a 0.0160n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311766
PNG
(2-Cyclobutyl-7-(4-fluorophenyl)-8-(7-methyl-1H-ind...)
Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(ccn2nc(nc12)C1CCC1)-c1ccc(F)cc1
PDB

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US Patent
n/an/a 0.0250n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311848
PNG
(8-(7-Chloro-1H-indazol-5-yl)-2-isopropyl-7-(triflu...)
Show SMILES CC(C)c1cn2ccc(c(-c3cc(Cl)c4[nH]ncc4c3)c2n1)C(F)(F)F
PDB

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US Patent
n/an/a 0.0250n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311811
PNG
(7-Isopropyl-8-(7-methyl-1H-indazol-5-yl)-2-(triflu...)
Show SMILES CC(C)c1ccn2nc(nc2c1-c1cc(C)c2[nH]ncc2c1)C(F)(F)F
PDB

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US Patent
n/an/a 0.0320n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311806
PNG
(7-(4-Fluorophenyl)-8-(7-methyl-1H-indazol-5-yl)-2-...)
Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(ccn2nc(nc12)C(F)(F)F)-c1ccc(F)cc1
PDB

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US Patent
n/an/a 0.0320n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311808
PNG
(2-(Difluoromethyl)-7-(4-fluorophenyl)-8-(7-methyl-...)
Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(ccn2nc(nc12)C(F)F)-c1ccc(F)cc1
PDB

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PC sid
UniChem
US Patent
n/an/a 0.0320n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311847
PNG
(5-(2,7-Bis(trifluoromethyl)imidazo[1,2-a]pyridin-8...)
Show SMILES FC(F)(F)c1cn2ccc(c(-c3cc(Cl)c4[nH]ncc4c3)c2n1)C(F)(F)F
PDB

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US Patent
n/an/a 0.0500n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311768
PNG
(7-Cyclopentyl-8-(7-methyl-1H-indazol-5-yl)-2-(trif...)
Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(ccn2nc(nc12)C(F)(F)F)C1CCCC1
PDB

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US Patent
n/an/a 0.0790n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311810
PNG
(2-Cyclopropyl-7-(4-fluorophenyl)-8-(7-methyl-1H-in...)
Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(ccn2nc(nc12)C1CC1)-c1ccc(F)cc1
PDB

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US Patent
n/an/a 0.0790n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311828
PNG
(8-(7-Chloro-1H-indazol-5-yl)-2-isopropyl-7-(triflu...)
Show SMILES CC(C)c1cn2cnc(c(-c3cc(Cl)c4[nH]ncc4c3)c2n1)C(F)(F)F
PDB

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US Patent
n/an/a 0.100n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311849
PNG
(2-Isopropyl-8-(7-methyl-1H-indazol-5-yl)-7-(triflu...)
Show SMILES CC(C)c1cn2ccc(c(-c3cc(C)c4[nH]ncc4c3)c2n1)C(F)(F)F
PDB

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US Patent
n/an/a 0.100n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311829
PNG
(8-(7-Chloro-1H-indazol-5-yl)-2-cyclopropyl-7-(trif...)
Show SMILES FC(F)(F)c1ncn2cc(nc2c1-c1cc(Cl)c2[nH]ncc2c1)C1CC1
PDB

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US Patent
n/an/a 0.126n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311843
PNG
(3-Chloro-8-(7-chloro-1H-indazol-5-yl)-2-cyclopropy...)
Show SMILES FC(F)(F)c1ncn2c(Cl)c(nc2c1-c1cc(Cl)c2[nH]ncc2c1)C1CC1
PDB

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US Patent
n/an/a 0.126n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311799
PNG
(8-(7-Chloro-1H-indazol-5-yl)-2-isopropyl-7-(triflu...)
Show SMILES CC(C)c1nc2c(-c3cc(Cl)c4[nH]ncc4c3)c(ccn2n1)C(F)(F)F
PDB

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PC sid
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US Patent
n/an/a 0.126n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311845
PNG
(5-(2,7-Bis(trifluoromethyl)imidazo[1,2-a]pyridin-8...)
Show SMILES FC(F)(F)c1cn2ccc(c(-c3cc4CC(=O)Nc4c(Cl)c3)c2n1)C(F)(F)F
Show InChI InChI=1S/C17H8ClF6N3O/c18-10-4-7(3-8-5-12(28)26-14(8)10)13-9(16(19,20)21)1-2-27-6-11(17(22,23)24)25-15(13)27/h1-4,6H,5H2,(H,26,28)
PDB

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US Patent
n/an/a 0.158n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311792
PNG
(8-(7-Chloro-1H-indazol-5-yl)-2-cyclopropyl-7-(trif...)
Show SMILES FC(F)(F)c1ccn2nc(nc2c1-c1cc(Cl)c2[nH]ncc2c1)C1CC1
PDB

UniProtKB/SwissProt

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PC sid
UniChem
US Patent
n/an/a 0.158n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311833
PNG
(8-(7-Chloro-1H-indazol-5-yl)-7-isopropyl-2-(triflu...)
Show SMILES CC(C)c1ncn2cc(nc2c1-c1cc(Cl)c2[nH]ncc2c1)C(F)(F)F
PDB

UniProtKB/SwissProt

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PC sid
UniChem
US Patent
n/an/a 0.158n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311793
PNG
(2-Cyclopropyl-8-(7-methyl-1H-indazol-5-yl)-7-(trif...)
Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(ccn2nc(nc12)C1CC1)C(F)(F)F
PDB

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US Patent
n/an/a 0.200n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311767
PNG
(6-(7-(4-Fluorophenyl)-2-(trifluoromethyl)-[1,2,4]t...)
Show SMILES Fc1ccc(cc1)-c1ccn2nc(nc2c1-c1ccc2[nH]c(=O)sc2c1)C(F)(F)F
PDB

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US Patent
n/an/a 0.251n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311830
PNG
(2-Cyclopropyl-8-(7-methyl-1H-indazol-5-yl)-7-(trif...)
Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(ncn2cc(nc12)C1CC1)C(F)(F)F
PDB

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UniChem
US Patent
n/an/a 0.251n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311781
PNG
(8-(7-Chloro-1H-indazol-5-yl)-2,7-bis(trifluorometh...)
Show SMILES FC(F)(F)c1nc2c(-c3cc(Cl)c4[nH]ncc4c3)c(ccn2n1)C(F)(F)F
PDB

UniProtKB/SwissProt

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PC sid
UniChem
US Patent
n/an/a 0.251n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311850
PNG
(2-Cyclopropyl-8-(7-methyl-1H-indazol-5-yl)-7-(trif...)
Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(ccn2cc(nc12)C1CC1)C(F)(F)F
PDB

UniProtKB/SwissProt

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PC sid
UniChem
US Patent
n/an/a 0.251n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311831
PNG
(7-Chloro-5-[2-cyclopropyl-7-(trifluoromethyl)imida...)
Show SMILES FC(F)(F)c1ncn2cc(nc2c1-c1cc2CC(=O)Nc2c(Cl)c1)C1CC1
Show InChI InChI=1S/C18H12ClF3N4O/c19-11-4-9(3-10-5-13(27)25-15(10)11)14-16(18(20,21)22)23-7-26-6-12(8-1-2-8)24-17(14)26/h3-4,6-8H,1-2,5H2,(H,25,27)
PDB

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US Patent
n/an/a 0.316n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311783
PNG
(5-(2,7-Bis(trifluoromethyl)-[1,2,4]triazolo[1,5-a]...)
Show SMILES FC(F)(F)c1nc2c(-c3cc4CC(=O)Nc4c(Cl)c3)c(ccn2n1)C(F)(F)F
Show InChI InChI=1S/C16H7ClF6N4O/c17-9-4-6(3-7-5-10(28)24-12(7)9)11-8(15(18,19)20)1-2-27-13(11)25-14(26-27)16(21,22)23/h1-4H,5H2,(H,24,28)
PDB

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US Patent
n/an/a 0.316n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311769
PNG
(7-(Azetidin-1-yl)-8-(7-methyl-1H-indazol-5-yl)-2-(...)
Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(ccn2nc(nc12)C(F)(F)F)N1CCC1
PDB

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US Patent
n/an/a 0.316n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311834
PNG
(8-(7-Chloro-1H-indazol-5-yl)-2-(difluoromethyl)-7-...)
Show SMILES CC(C)c1ncn2cc(nc2c1-c1cc(Cl)c2[nH]ncc2c1)C(F)F
PDB

UniProtKB/SwissProt

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PC sid
UniChem
US Patent
n/an/a 0.316n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311824
PNG
(5-(2,7-Bis(trifluoromethyl)imidazo[1,2-a]pyridin-8...)
Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(ccn2cc(nc12)C(F)(F)F)C(F)(F)F
PDB

UniProtKB/SwissProt

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PC sid
UniChem
US Patent
n/an/a 0.316n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311844
PNG
(8-(7-Chloro-1H-indazol-5-yl)-2-cyclopropyl-3-fluor...)
Show SMILES Fc1c(nc2c(-c3cc(Cl)c4[nH]ncc4c3)c(ncn12)C(F)(F)F)C1CC1
PDB

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PC sid
UniChem
US Patent
n/an/a 0.316n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311754
PNG
(8-(7-Chloro-1H-indazol-5-yl)-2-(difluoromethyl)-7-...)
Show SMILES FC(F)c1nc2c(-c3cc(Cl)c4[nH]ncc4c3)c(ccn2n1)C(F)(F)F
PDB

UniProtKB/SwissProt

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PC sid
UniChem
US Patent
n/an/a 0.316n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311775
PNG
(8-(7-Chloro-1H-indazol-5-yl)-2,7-bis(trifluorometh...)
Show SMILES FC(F)(F)c1nc2c(-c3cc(Cl)c4[nH]ncc4c3)c(ncn2n1)C(F)(F)F
PDB

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n/an/a 0.316n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311785
PNG
(8-(7-Chloro-1H-indazol-5-yl)-7-(difluoromethyl)-2-...)
Show SMILES FC(F)c1ccn2nc(nc2c1-c1cc(Cl)c2[nH]ncc2c1)C(F)(F)F
PDB

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n/an/a 0.398n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311846
PNG
(5-(2,7-Bis(trifluoromethyl)imidazo[1,2-a]pyridin-8...)
Show SMILES Cc1cc(cc2CC(=O)Nc12)-c1c(ccn2cc(nc12)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C18H11F6N3O/c1-8-4-9(5-10-6-13(28)26-15(8)10)14-11(17(19,20)21)2-3-27-7-12(18(22,23)24)25-16(14)27/h2-5,7H,6H2,1H3,(H,26,28)
PDB

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n/an/a 0.398n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311796
PNG
(8-(7-Chloro-1H-indazol-5-yl)-2-ethyl-7-(trifluorom...)
Show SMILES CCc1nc2c(-c3cc(Cl)c4[nH]ncc4c3)c(ccn2n1)C(F)(F)F
PDB

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n/an/a 0.398n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311776
PNG
(8-(7-Chloro-1H-indazol-5-yl)-2-(difluoromethyl)-7-...)
Show SMILES FC(F)c1nc2c(-c3cc(Cl)c4[nH]ncc4c3)c(ncn2n1)C(F)(F)F
PDB

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n/an/a 0.398n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311851
PNG
(2-Ethyl-8-(7-methyl-1H-indazol-5-yl)-7-(trifluorom...)
Show SMILES CCc1cn2ccc(c(-c3cc(C)c4[nH]ncc4c3)c2n1)C(F)(F)F
PDB

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n/an/a 0.398n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311826
PNG
(8-(7-Chloro-1H-indazol-5-yl)-2-ethyl-7-(trifluorom...)
Show SMILES CCc1cn2cnc(c(-c3cc(Cl)c4[nH]ncc4c3)c2n1)C(F)(F)F
PDB

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n/an/a 0.501n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311852
PNG
(2-(Difluoromethyl)-8-(7-methyl-1H-indazol-5-yl)-7-...)
Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(ccn2cc(nc12)C(F)F)C(F)(F)F
PDB

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n/an/a 0.501n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311782
PNG
(8-(7-Methyl-1H-indazol-5-yl)-2,7-bis(trifluorometh...)
Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(ccn2nc(nc12)C(F)(F)F)C(F)(F)F
PDB

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n/an/a 0.501n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311787
PNG
(7-Chloro-5-(7-(difluoromethyl)-2-(trifluoromethyl)...)
Show SMILES FC(F)c1ccn2nc(nc2c1-c1cc2CC(=O)Nc2c(Cl)c1)C(F)(F)F
Show InChI InChI=1S/C16H8ClF5N4O/c17-9-4-6(3-7-5-10(27)23-12(7)9)11-8(13(18)19)1-2-26-14(11)24-15(25-26)16(20,21)22/h1-4,13H,5H2,(H,23,27)
PDB

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n/an/a 0.631n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311842
PNG
(8-(7-Chloro-1H-indazol-5-yl)-7-cyclopropyl-2-(difl...)
Show SMILES Cc1nc(C2CC2)c(-c2cc(Cl)c3[nH]ncc3c2)c2nc(cn12)C(F)F
PDB

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n/an/a 0.631n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311786
PNG
(8-(7-Methyl-1H-indazol-5-yl)-7-(difluoromethyl)-2-...)
Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(ccn2nc(nc12)C(F)(F)F)C(F)F
PDB

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n/an/a 0.631n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311801
PNG
(5-[2-Isopropyl-7-(trifluoromethyl)-[1,2,4]triazolo...)
Show SMILES CC(C)c1nc2c(-c3cc4CC(=O)Nc4c(C)c3)c(ccn2n1)C(F)(F)F
Show InChI InChI=1S/C19H17F3N4O/c1-9(2)17-24-18-15(13(19(20,21)22)4-5-26(18)25-17)11-6-10(3)16-12(7-11)8-14(27)23-16/h4-7,9H,8H2,1-3H3,(H,23,27)
PDB

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n/an/a 0.631n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311790
PNG
(7-Ethyl-8-(7-methyl-1H-indazol-5-yl)-2-(trifluorom...)
Show SMILES CCc1ccn2nc(nc2c1-c1cc(C)c2[nH]ncc2c1)C(F)(F)F
PDB

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n/an/a 0.794n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311784
PNG
(5-(2,7-Bis(trifluoromethyl)-[1,2,4]triazolo[1,5-a]...)
Show SMILES Cc1cc(cc2CC(=O)Nc12)-c1c(ccn2nc(nc12)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C17H10F6N4O/c1-7-4-8(5-9-6-11(28)24-13(7)9)12-10(16(18,19)20)2-3-27-14(12)25-15(26-27)17(21,22)23/h2-5H,6H2,1H3,(H,24,28)
PDB

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n/an/a 0.794n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311835
PNG
(8-(7-Chloro-1H-indazol-5-yl)-7-ethyl-2-(trifluorom...)
Show SMILES CCc1ncn2cc(nc2c1-c1cc(Cl)c2[nH]ncc2c1)C(F)(F)F
PDB

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n/an/a 0.794n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311778
PNG
(8-(7-Methyl-1H-indazol-5-yl)-2-(difluoromethyl)-7-...)
Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(ccn2nc(nc12)C(F)F)C(F)(F)F
PDB

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Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311773
PNG
(7-Methyl-5-[7-methyl-2-(trifluoromethyl)imidazo[1,...)
Show SMILES Cc1cc(cc2CC(=O)Nc12)-c1c(C)ccn2nc(nc12)C(F)(F)F
Show InChI InChI=1S/C17H13F3N4O/c1-8-3-4-24-15(22-16(23-24)17(18,19)20)13(8)10-5-9(2)14-11(6-10)7-12(25)21-14/h3-6H,7H2,1-2H3,(H,21,25)
PDB

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Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311839
PNG
(8-(7-Chloro-1H-indazol-5-yl)-7-cyclopropyl-2-(trif...)
Show SMILES FC(F)(F)c1cn2cnc(C3CC3)c(-c3cc(Cl)c4[nH]ncc4c3)c2n1
PDB

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Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311803
PNG
(7-Chloro-8-(7-chloro-1H-indazol-5-yl)-2-(trifluoro...)
Show SMILES FC(F)(F)c1nc2c(c(Cl)ccn2n1)-c1cc(Cl)c2[nH]ncc2c1
PDB

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Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311804
PNG
(7-(4-Fluorophenyl)-8-(7-fluoro-1H-indazol-5-yl)-2-...)
Show SMILES Fc1ccc(cc1)-c1ccn2nc(nc2c1-c1cc(F)c2[nH]ncc2c1)C(F)(F)F
PDB

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Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311788
PNG
(7-Methyl-5-(7-(difluoromethyl)-2-(trifluoromethyl)...)
Show SMILES Cc1cc(cc2CC(=O)Nc12)-c1c(ccn2nc(nc12)C(F)(F)F)C(F)F
Show InChI InChI=1S/C17H11F5N4O/c1-7-4-8(5-9-6-11(27)23-13(7)9)12-10(14(18)19)2-3-26-15(12)24-16(25-26)17(20,21)22/h2-5,14H,6H2,1H3,(H,23,27)
PDB

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Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311822
PNG
(7-Chloro-8-(7-methyl-1H-indazol-5-yl)-2-(trifluoro...)
Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(Cl)ccn2cc(nc12)C(F)(F)F
PDB

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Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311825
PNG
(8-(7-Methyl-1H-indazol-5-yl)-2,7-bis(trifluorometh...)
Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(ncn2cc(nc12)C(F)(F)F)C(F)(F)F
PDB

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n/an/a 1.26n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311837
PNG
(8-(7-Chloro-1H-indazol-5-yl)-2-(difluoromethyl)-7-...)
Show SMILES CCc1ncn2cc(nc2c1-c1cc(Cl)c2[nH]ncc2c1)C(F)F
PDB

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Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311779
PNG
(7-Chloro-5-(2-(difluoromethyl)-7-(trifluoromethyl)...)
Show SMILES FC(F)c1nc2c(-c3cc4CC(=O)Nc4c(Cl)c3)c(ccn2n1)C(F)(F)F
Show InChI InChI=1S/C16H8ClF5N4O/c17-9-4-6(3-7-5-10(27)23-12(7)9)11-8(16(20,21)22)1-2-26-15(11)24-14(25-26)13(18)19/h1-4,13H,5H2,(H,23,27)
PDB

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n/an/a 1.26n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311841
PNG
(8-(7-Chloro-1H-indazol-5-yl)-7-cyclopropyl-5-methy...)
Show SMILES Cc1nc(C2CC2)c(-c2cc(Cl)c3[nH]ncc3c2)c2nc(cn12)C(F)(F)F
PDB

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Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311797
PNG
(2-Ethyl-8-(7-methyl-1H-indazol-5-yl)-7-(trifluorom...)
Show SMILES CCc1nc2c(-c3cc(C)c4[nH]ncc4c3)c(ccn2n1)C(F)(F)F
PDB

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n/an/a 1.58n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311827
PNG
(2-Ethyl-8-(7-methyl-1H-indazol-5-yl)-7-(trifluorom...)
Show SMILES CCc1cn2cnc(c(-c3cc(C)c4[nH]ncc4c3)c2n1)C(F)(F)F
PDB

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n/an/a 1.58n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311798
PNG
(5-[2-Ethyl-7-(trifluoromethyl)-[1,2,4]triazolo[1,5...)
Show SMILES CCc1nc2c(-c3cc4CC(=O)Nc4c(C)c3)c(ccn2n1)C(F)(F)F
Show InChI InChI=1S/C18H15F3N4O/c1-3-13-22-17-15(12(18(19,20)21)4-5-25(17)24-13)10-6-9(2)16-11(7-10)8-14(26)23-16/h4-7H,3,8H2,1-2H3,(H,23,26)
PDB

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n/an/a 2n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311836
PNG
(7-Ethyl-8-(7-methyl-1H-indazol-5-yl)-2-(trifluorom...)
Show SMILES CCc1ncn2cc(nc2c1-c1cc(C)c2[nH]ncc2c1)C(F)(F)F
PDB

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Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311809
PNG
(7-(4-Fluorophenyl)-2-(methoxymethyl)-8-(7-methyl-1...)
Show SMILES COCc1nc2c(-c3cc(C)c4[nH]ncc4c3)c(ccn2n1)-c1ccc(F)cc1
PDB

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n/an/a 2n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311777
PNG
(2-(Difluoromethyl)-8-(7-methyl-1H-indazol-5-yl)-7-...)
Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(ncn2nc(nc12)C(F)F)C(F)(F)F
PDB

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Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311800
PNG
(2-Isopropyl-8-(7-methyl-1H-indazol-5-yl)-7-(triflu...)
Show SMILES CC(C)c1nc2c(-c3cc(C)c4[nH]ncc4c3)c(ccn2n1)C(F)(F)F
PDB

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Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311770
PNG
(7-(3-Fluoroazetidin-1-yl)-8-(7-methyl-1H-indazol-5...)
Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(ccn2nc(nc12)C(F)(F)F)N1CC(F)C1
PDB

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n/an/a 2.51n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311840
PNG
(8-(7-Chloro-1H-indazol-5-yl)-7-cyclopropyl-2-(difl...)
Show SMILES FC(F)c1cn2cnc(C3CC3)c(-c3cc(Cl)c4[nH]ncc4c3)c2n1
PDB

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n/an/a 2.51n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311780
PNG
(7-Methyl-5-(2-(difluoromethyl)-7-(trifluoromethyl)...)
Show SMILES Cc1cc(cc2CC(=O)Nc12)-c1c(ccn2nc(nc12)C(F)F)C(F)(F)F
Show InChI InChI=1S/C17H11F5N4O/c1-7-4-8(5-9-6-11(27)23-13(7)9)12-10(17(20,21)22)2-3-26-16(12)24-15(25-26)14(18)19/h2-5,14H,6H2,1H3,(H,23,27)
PDB

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n/an/a 2.51n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311764
PNG
(7-Chloro-8-(7-methyl-1H-indazol-5-yl)-2-(trifluoro...)
Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(Cl)ccn2nc(nc12)C(F)(F)F
PDB

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n/an/a 3.16n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311838
PNG
(8-(7-Chloro-1H-indazol-5-yl)-7-methyl-2-(trifluoro...)
Show SMILES Cc1ncn2cc(nc2c1-c1cc(Cl)c2[nH]ncc2c1)C(F)(F)F
PDB

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n/an/a 3.16n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311774
PNG
(5-(7-(4-Fluorophenyl)-2-(trifluoromethyl)imidazo[1...)
Show SMILES Fc1ccc(cc1)-c1ccn2nc(nc2c1-c1ccc2[nH]ncc2c1)C(F)(F)F
PDB

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n/an/a 3.16n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311789
PNG
(7-Methyl-8-(7-methyl-1H-indazol-5-yl)-2-(trifluoro...)
Show SMILES Cc1ccn2nc(nc2c1-c1cc(C)c2[nH]ncc2c1)C(F)(F)F
PDB

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n/an/a 3.98n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311794
PNG
(8-(7-Chloro-1H-indazol-5-yl)-2-methyl-7-(trifluoro...)
Show SMILES Cc1nc2c(-c3cc(Cl)c4[nH]ncc4c3)c(ccn2n1)C(F)(F)F
PDB

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n/an/a 5.01n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311821
PNG
(7-Methoxy-8-(7-methyl-1H-indazol-5-yl)-2-(trifluor...)
Show SMILES COc1ccn2cc(nc2c1-c1cc(C)c2[nH]ncc2c1)C(F)(F)F
PDB

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n/an/a 7.94n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311853
PNG
(2-Methyl-8-(7-methyl-1H-indazol-5-yl)-7-(trifluoro...)
Show SMILES Cc1cn2ccc(c(-c3cc(C)c4[nH]ncc4c3)c2n1)C(F)(F)F
PDB

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n/an/a 7.94n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311765
PNG
(6-(2,7-Bis(trifluoromethyl)-[1,2,4]triazolo[1,5-a]...)
Show SMILES FC(F)(F)c1nc2c(-c3ccc4[nH]c(=O)sc4c3)c(ccn2n1)C(F)(F)F
PDB

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n/an/a 7.94n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311814
PNG
(7-Methyl-8-(7-methyl-1H-indazol-5-yl)-2-(trifluoro...)
Show SMILES Cc1ccn2cc(nc2c1-c1cc(C)c2[nH]ncc2c1)C(F)(F)F
PDB

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n/an/a 10n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311818
PNG
(7-Methyl-8-(7-methyl-1H-indazol-5-yl)-2-phenyl-imi...)
Show SMILES Cc1ccn2cc(nc2c1-c1cc(C)c2[nH]ncc2c1)-c1ccccc1
PDB

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n/an/a 12.6n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311795
PNG
(2-Methyl-8-(7-methyl-1H-indazol-5-yl)-7-(trifluoro...)
Show SMILES Cc1nc2c(-c3cc(C)c4[nH]ncc4c3)c(ccn2n1)C(F)(F)F
PDB

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n/an/a 12.6n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311820
PNG
(5-[7-Methoxy-2-(trifluoromethyl)imidazo[1,2-a]pyri...)
Show SMILES COc1ccn2cc(nc2c1-c1cc2CC(=O)Nc2c(C)c1)C(F)(F)F
Show InChI InChI=1S/C18H14F3N3O2/c1-9-5-10(6-11-7-14(25)23-16(9)11)15-12(26-2)3-4-24-8-13(18(19,20)21)22-17(15)24/h3-6,8H,7H2,1-2H3,(H,23,25)
PDB

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n/an/a 15.8n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311772
PNG
(8-(7-Methyl-1H-indazol-5-yl)-2-(trifluoromethyl)-[...)
Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(ccn2nc(nc12)C(F)(F)F)C#N
PDB

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Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311807
PNG
(8-(3-Fluoro-1H-indazol-5-yl)-7-(4-fluorophenyl)-2-...)
Show SMILES Fc1n[nH]c2ccc(cc12)-c1c(ccn2nc(nc12)C(F)(F)F)-c1ccc(F)cc1
PDB

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n/an/a 25.1n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311791
PNG
(7-Methoxy-8-(7-methyl-1H-indazol-5-yl)-2-(trifluor...)
Show SMILES COc1ccn2nc(nc2c1-c1cc(C)c2[nH]ncc2c1)C(F)(F)F
PDB

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n/an/a 25.1n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311819
PNG
(2-Cyclopropyl-7-methyl-8-(7-methyl-1H-indazol-5-yl...)
Show SMILES Cc1ccn2cc(nc2c1-c1cc(C)c2[nH]ncc2c1)C1CC1
PDB

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n/an/a 25.1n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311823
PNG
(5-(2,7-Bis(trifluoromethyl)imidazo[1,2-a]pyridin-8...)
Show SMILES FC(F)(F)c1cn2ccc(c(-c3ccc4[nH]ncc4c3)c2n1)C(F)(F)F
PDB

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n/an/a 31.6n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311815
PNG
(2-tert-Butyl-7-methyl-8-(7-methyl-1H-indazol-5-yl)...)
Show SMILES Cc1ccn2cc(nc2c1-c1cc(C)c2[nH]ncc2c1)C(C)(C)C
PDB

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n/an/a 31.6n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311817
PNG
(7-Methyl-5-(7-methyl-2-phenyl-imidazo[1,2-a]pyridi...)
Show SMILES Cc1cc(cc2CC(=O)Nc12)-c1c(C)ccn2cc(nc12)-c1ccccc1
Show InChI InChI=1S/C23H19N3O/c1-14-8-9-26-13-19(16-6-4-3-5-7-16)24-23(26)21(14)17-10-15(2)22-18(11-17)12-20(27)25-22/h3-11,13H,12H2,1-2H3,(H,25,27)
PDB

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n/an/a 39.8n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311813
PNG
(7-Fluoro-5-[7-methyl-2-(trifluoromethyl)imidazo[1,...)
Show SMILES Cc1ccn2cc(nc2c1-c1cc2CC(=O)Nc2c(F)c1)C(F)(F)F
Show InChI InChI=1S/C17H11F4N3O/c1-8-2-3-24-7-12(17(19,20)21)22-16(24)14(8)9-4-10-6-13(25)23-15(10)11(18)5-9/h2-5,7H,6H2,1H3,(H,23,25)
PDB

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n/an/a 63.1n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311812
PNG
(8-(1H-Indazol-5-yl)-7-methyl-2-(trifluoromethyl)im...)
Show SMILES Cc1ccn2cc(nc2c1-c1ccc2[nH]ncc2c1)C(F)(F)F
PDB

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n/an/a 63.1n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311816
PNG
(5-(2-tert-Butyl-7-methyl-imidazo[1,2-a]pyridin-8-y...)
Show SMILES Cc1cc(cc2CC(=O)Nc12)-c1c(C)ccn2cc(nc12)C(C)(C)C
Show InChI InChI=1S/C21H23N3O/c1-12-6-7-24-11-16(21(3,4)5)22-20(24)18(12)14-8-13(2)19-15(9-14)10-17(25)23-19/h6-9,11H,10H2,1-5H3,(H,23,25)
PDB

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n/an/a 79.4n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311802
PNG
(2-Isopropyl-7-methyl-8-(7-methyl-1H-indazol-5-yl)-...)
Show SMILES CC(C)c1nc2c(c(C)ccn2n1)-c1cc(C)c2[nH]ncc2c1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 126n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM311832
PNG
(5-[2-Cyclopropyl-7-(trifluoromethyl)imidazo[1,2-c]...)
Show SMILES Fc1cc(cc2CC(=O)Nc12)-c1c(ncn2cc(nc12)C1CC1)C(F)(F)F
Show InChI InChI=1S/C18H12F4N4O/c19-11-4-9(3-10-5-13(27)25-15(10)11)14-16(18(20,21)22)23-7-26-6-12(8-1-2-8)24-17(14)26/h3-4,6-8H,1-2,5H2,(H,25,27)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 5.01E+3n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...


US Patent US10155769 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%