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Patent code US10155972

Compile Data Set for Download or QSAR
Found 10 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tryptophan 2,3-dioxygenase


(Homo sapiens)
BDBM311863
PNG
(US10155972, Compound Incyte 1)
Show SMILES Nc1nonc1\C(Nc1cc(F)cc(Cl)c1)=N/O
Show InChI InChI=1S/C9H7ClFN5O2/c10-4-1-5(11)3-6(2-4)13-9(14-17)7-8(12)16-18-15-7/h1-3,17H,(H2,12,16)(H,13,14)
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/a 398n/an/an/an/an/an/a



Iomet Pharma Ltd.

US Patent


Assay Description
In two separate assays, 0.045 μg/μl of human IDO protein was pre-incubated for 10 min at RT with test compounds NewLink 1 and Incyte 1 in t...


US Patent US10155972 (2018)

More data for this
Ligand-Target Pair
Tryptophan 2,3-dioxygenase


(Homo sapiens)
BDBM50126144
PNG
(CHEMBL3629569 | US10155972, Compound NewLink 1)
Show SMILES OC(CC1c2ccccc2-c2cncn12)C1CCCCC1
Show InChI InChI=1S/C18H22N2O/c21-18(13-6-2-1-3-7-13)10-16-14-8-4-5-9-15(14)17-11-19-12-20(16)17/h4-5,8-9,11-13,16,18,21H,1-3,6-7,10H2
PDB

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PDB
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US Patent
n/an/a 398n/an/an/an/an/an/a



Iomet Pharma Ltd.

US Patent


Assay Description
In two separate assays, 0.045 μg/μl of human IDO protein was pre-incubated for 10 min at RT with test compounds NewLink 1 and Incyte 1 in t...


US Patent US10155972 (2018)

More data for this
Ligand-Target Pair
htdo biochemical assay


(Homo sapiens)
BDBM50126144
PNG
(CHEMBL3629569 | US10155972, Compound NewLink 1)
Show SMILES OC(CC1c2ccccc2-c2cncn12)C1CCCCC1
Show InChI InChI=1S/C18H22N2O/c21-18(13-6-2-1-3-7-13)10-16-14-8-4-5-9-15(14)17-11-19-12-20(16)17/h4-5,8-9,11-13,16,18,21H,1-3,6-7,10H2
PDB

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US Patent
n/an/a 501n/an/an/an/an/an/a



Iomet Pharma Ltd.

US Patent


Assay Description
In two separate assays, 2.5 μg/μl of human TDO protein was pre-incubated for 10 minutes at RT with test compounds 680C91 and LM10 in the pr...


US Patent US10155972 (2018)

More data for this
Ligand-Target Pair
htdo biochemical assay


(Homo sapiens)
BDBM311863
PNG
(US10155972, Compound Incyte 1)
Show SMILES Nc1nonc1\C(Nc1cc(F)cc(Cl)c1)=N/O
Show InChI InChI=1S/C9H7ClFN5O2/c10-4-1-5(11)3-6(2-4)13-9(14-17)7-8(12)16-18-15-7/h1-3,17H,(H2,12,16)(H,13,14)
PDB

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PC sid
UniChem
US Patent
n/an/a 2.51E+3n/an/an/an/an/an/a



Iomet Pharma Ltd.

US Patent


Assay Description
In two separate assays, 2.5 μg/μl of human TDO protein was pre-incubated for 10 minutes at RT with test compounds 680C91 and LM10 in the pr...


US Patent US10155972 (2018)

More data for this
Ligand-Target Pair
Tryptophan 2,3-dioxygenase


(Homo sapiens)
BDBM311866
PNG
(US10155972, IOmet compound B)
Show SMILES CS(=O)(=O)N1CCC(=CC1)c1c[nH]c2ccccc12
PDB

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n/an/a 3.98E+3n/an/an/an/an/an/a



Iomet Pharma Ltd.

US Patent


Assay Description
In two separate assays, 2.5 μg/μl of human TDO protein was pre-incubated for 10 minutes at RT with test compounds 680C91 and LM10 in the pr...


US Patent US10155972 (2018)

More data for this
Ligand-Target Pair
Tryptophan 2,3-dioxygenase


(Homo sapiens)
BDBM311865
PNG
(US10155972, IOmet compound A)
Show SMILES NS(=O)(=O)N1CCC(=CC1)c1c[nH]c2cc(F)ccc12
PDB

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PC sid
UniChem
US Patent
n/an/a 6.31E+3n/an/an/an/an/an/a



Iomet Pharma Ltd.

US Patent


Assay Description
In two separate assays, 2.5 μg/μl of human TDO protein was pre-incubated for 10 minutes at RT with test compounds 680C91 and LM10 in the pr...


US Patent US10155972 (2018)

More data for this
Ligand-Target Pair
htdo biochemical assay


(Homo sapiens)
BDBM311862
PNG
(US10155972, Compound LM10)
Show SMILES Fc1ccc2c(\C=C\c3nnn[nH]3)c[nH]c2c1
Show InChI InChI=1S/C11H6FN5/c12-8-2-3-9-7(6-13-10(9)5-8)1-4-11-14-16-17-15-11/h1-6H/b7-1+
PDB

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US Patent
n/an/a 7.94E+3n/an/an/an/an/an/a



Iomet Pharma Ltd.

US Patent


Assay Description
In two separate assays, 2.5 μg/μl of human TDO protein was pre-incubated for 10 minutes at RT with test compounds 680C91 and LM10 in the pr...


US Patent US10155972 (2018)

More data for this
Ligand-Target Pair
htdo biochemical assay


(Homo sapiens)
BDBM50289137
PNG
(6-Fluoro-3-((E)-2-pyridin-3-yl-vinyl)-1H-indole | ...)
Show SMILES Fc1ccc2c(\C=C\c3cccnc3)c[nH]c2c1
Show InChI InChI=1S/C15H11FN2/c16-13-5-6-14-12(10-18-15(14)8-13)4-3-11-2-1-7-17-9-11/h1-10,18H/b4-3+
PDB

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CHEMBL
PC cid
PC sid
UniChem

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US Patent
n/an/a 1.00E+4n/an/an/an/an/an/a



Iomet Pharma Ltd.

US Patent


Assay Description
In two separate assays, 2.5 μg/μl of human TDO protein was pre-incubated for 10 minutes at RT with test compounds 680C91 and LM10 in the pr...


US Patent US10155972 (2018)

More data for this
Ligand-Target Pair
Tryptophan 2,3-dioxygenase


(Homo sapiens)
BDBM311866
PNG
(US10155972, IOmet compound B)
Show SMILES CS(=O)(=O)N1CCC(=CC1)c1c[nH]c2ccccc12
PDB

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UniChem
US Patent
n/an/a<1.26E+5n/an/an/an/an/an/a



Iomet Pharma Ltd.

US Patent


Assay Description
In two separate assays, 0.045 μg/μl of human IDO protein was pre-incubated for 10 min at RT with test compounds NewLink 1 and Incyte 1 in t...


US Patent US10155972 (2018)

More data for this
Ligand-Target Pair
Tryptophan 2,3-dioxygenase


(Homo sapiens)
BDBM311865
PNG
(US10155972, IOmet compound A)
Show SMILES NS(=O)(=O)N1CCC(=CC1)c1c[nH]c2cc(F)ccc12
PDB

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UniChem
US Patent
n/an/a<1.26E+5n/an/an/an/an/an/a



Iomet Pharma Ltd.

US Patent


Assay Description
In two separate assays, 0.045 μg/μl of human IDO protein was pre-incubated for 10 min at RT with test compounds NewLink 1 and Incyte 1 in t...


US Patent US10155972 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%