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Patent code US10166216

Compile Data Set for Download or QSAR
Found 151 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313078
PNG
(N3-(3-fluoro-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-...)
Show SMILES Nc1nc(Nc2ccc(OCCN3CCCC3)c(F)c2)nn1-c1ccccn1
Show InChI InChI=1S/C19H22FN7O/c20-15-13-14(6-7-16(15)28-12-11-26-9-3-4-10-26)23-19-24-18(21)27(25-19)17-5-1-2-8-22-17/h1-2,5-8,13H,3-4,9-12H2,(H3,21,23,24,25)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313083
PNG
(N3-(3-chloro-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-...)
Show SMILES Nc1nc(Nc2ccc(OCCN3CCCC3)c(Cl)c2)nn1-c1nccc2ccccc12
Show InChI InChI=1S/C23H24ClN7O/c24-19-15-17(7-8-20(19)32-14-13-30-11-3-4-12-30)27-23-28-22(25)31(29-23)21-18-6-2-1-5-16(18)9-10-26-21/h1-2,5-10,15H,3-4,11-14H2,(H3,25,27,28,29)
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313136
PNG
(1-(isoquinolin-1-yl)-N3-(4-(1-methylpiperidin-4-yl...)
Show SMILES CN1CCC(CC1)c1ccc(Nc2nc(N)n(n2)-c2nccc3ccccc23)cc1
Show InChI InChI=1S/C23H25N7/c1-29-14-11-17(12-15-29)16-6-8-19(9-7-16)26-23-27-22(24)30(28-23)21-20-5-3-2-4-18(20)10-13-25-21/h2-10,13,17H,11-12,14-15H2,1H3,(H3,24,26,27,28)
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313145
PNG
(1-(7-methylthieno[3,2-d]pyrimidin-4-yl)-N3-(4-(4-(...)
Show SMILES Cc1csc2c(ncnc12)-n1nc(Nc2ccc(cc2)C(=O)N2CCN(CC2)C2CCCC2)nc1N
Show InChI InChI=1S/C25H29N9OS/c1-16-14-36-21-20(16)27-15-28-22(21)34-24(26)30-25(31-34)29-18-8-6-17(7-9-18)23(35)33-12-10-32(11-13-33)19-4-2-3-5-19/h6-9,14-15,19H,2-5,10-13H2,1H3,(H3,26,29,30,31)
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313015
PNG
(N-{2-[(4aR,6S,8aR)-2-amino-6-methyl-4,4a,5,6-tetra...)
Show SMILES Nc1nc(Nc2ccc(OCCN3CCCC3)cc2)nn1-c1nncc2ccccc12
Show InChI InChI=1S/C22H24N8O/c23-21-26-22(28-30(21)20-19-6-2-1-5-16(19)15-24-27-20)25-17-7-9-18(10-8-17)31-14-13-29-11-3-4-12-29/h1-2,5-10,15H,3-4,11-14H2,(H3,23,25,26,28)
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313084
PNG
(1-(6-fluoroquinazolin-4-yl)-N3-(4-(2-(pyrrolidin-1...)
Show SMILES Nc1nc(Nc2ccc(OCCN3CCCC3)cc2)nn1-c1ncnc2ccc(F)cc12
Show InChI InChI=1S/C22H23FN8O/c23-15-3-8-19-18(13-15)20(26-14-25-19)31-21(24)28-22(29-31)27-16-4-6-17(7-5-16)32-12-11-30-9-1-2-10-30/h3-8,13-14H,1-2,9-12H2,(H3,24,27,28,29)
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313085
PNG
(N3-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-1-(thieno...)
Show SMILES Nc1nc(Nc2ccc(OCCN3CCCC3)cc2)nn1-c1nccc2ccsc12
Show InChI InChI=1S/C21H23N7OS/c22-20-25-21(26-28(20)19-18-15(7-9-23-19)8-14-30-18)24-16-3-5-17(6-4-16)29-13-12-27-10-1-2-11-27/h3-9,14H,1-2,10-13H2,(H3,22,24,25,26)
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313092
PNG
(1-(benzothieno[3,2-d]pyrimidin-4-yl)-N3-(4-(2-(pyr...)
Show SMILES Nc1nc(Nc2ccc(OCCN3CCCC3)cc2)nn1-c1ncnc2sc3ccccc3c12
Show InChI InChI=1S/C24H24N8OS/c25-23-29-24(28-16-7-9-17(10-8-16)33-14-13-31-11-3-4-12-31)30-32(23)21-20-18-5-1-2-6-19(18)34-22(20)27-15-26-21/h1-2,5-10,15H,3-4,11-14H2,(H3,25,28,29,30)
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313099
PNG
(5-(5-amino-3-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyla...)
Show SMILES Nc1nc(Nc2ccc(OCCN3CCCC3)cc2)nn1-c1nccc2[nH]c(=O)ccc12
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313128
PNG
(N3-(3-chloro-4-morpholinophenyl)-1-(6,7-dimethoxyq...)
Show SMILES COc1cc2ncnc(-n3nc(Nc4ccc(N5CCOCC5)c(Cl)c4)nc3N)c2cc1OC
Show InChI InChI=1S/C22H23ClN8O3/c1-32-18-10-14-16(11-19(18)33-2)25-12-26-20(14)31-21(24)28-22(29-31)27-13-3-4-17(15(23)9-13)30-5-7-34-8-6-30/h3-4,9-12H,5-8H2,1-2H3,(H3,24,27,28,29)
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313131
PNG
(1-(6,7-dimethoxyquinazolin-4-yl)-N3-(3-fluoro-4-mo...)
Show SMILES COc1cc2ncnc(-n3nc(Nc4ccc(N5CCOCC5)c(F)c4)nc3N)c2cc1OC
Show InChI InChI=1S/C22H23FN8O3/c1-32-18-10-14-16(11-19(18)33-2)25-12-26-20(14)31-21(24)28-22(29-31)27-13-3-4-17(15(23)9-13)30-5-7-34-8-6-30/h3-4,9-12H,5-8H2,1-2H3,(H3,24,27,28,29)
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313132
PNG
(1-(isoquinolin-1-yl)-N3-(4-((4-methylpiperazin-1-y...)
Show SMILES CN1CCN(Cc2ccc(Nc3nc(N)n(n3)-c3nccc4ccccc34)cc2)CC1
Show InChI InChI=1S/C23H26N8/c1-29-12-14-30(15-13-29)16-17-6-8-19(9-7-17)26-23-27-22(24)31(28-23)21-20-5-3-2-4-18(20)10-11-25-21/h2-11H,12-16H2,1H3,(H3,24,26,27,28)
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313137
PNG
(1-(6,7-dimethoxyquinazolin-4-yl)-N3-(4-(1-methylpi...)
Show SMILES COc1cc2ncnc(-n3nc(Nc4ccc(cc4)C4CCN(C)CC4)nc3N)c2cc1OC
Show InChI InChI=1S/C24H28N8O2/c1-31-10-8-16(9-11-31)15-4-6-17(7-5-15)28-24-29-23(25)32(30-24)22-18-12-20(33-2)21(34-3)13-19(18)26-14-27-22/h4-7,12-14,16H,8-11H2,1-3H3,(H3,25,28,29,30)
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313143
PNG
(1-(6,7-dimethoxyisoquinolin-1-yl)-N3-(4-(1-methylp...)
Show SMILES COc1cc2ccnc(-n3nc(Nc4ccc(cc4)C4CCN(C)CC4)nc3N)c2cc1OC
Show InChI InChI=1S/C25H29N7O2/c1-31-12-9-17(10-13-31)16-4-6-19(7-5-16)28-25-29-24(26)32(30-25)23-20-15-22(34-3)21(33-2)14-18(20)8-11-27-23/h4-8,11,14-15,17H,9-10,12-13H2,1-3H3,(H3,26,28,29,30)
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313144
PNG
(1-(6,7-dimethoxyquinazolin-4-yl)-N3-(4-(4-(cyclope...)
Show SMILES COc1cc2ncnc(-n3nc(Nc4ccc(cc4)C(=O)N4CCN(CC4)C4CCCC4)nc3N)c2cc1OC
Show InChI InChI=1S/C28H33N9O3/c1-39-23-15-21-22(16-24(23)40-2)30-17-31-25(21)37-27(29)33-28(34-37)32-19-9-7-18(8-10-19)26(38)36-13-11-35(12-14-36)20-5-3-4-6-20/h7-10,15-17,20H,3-6,11-14H2,1-2H3,(H3,29,32,33,34)
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313149
PNG
(1-(7-methyl-2-chlorothieno[3,2-d] pyrimidin-4-yl)-...)
Show SMILES CCN(CC)C1CCN(C1)c1ccc(Nc2nc(N)n(n2)-c2nc(Cl)nc3c(C)csc23)cc1F
Show InChI InChI=1S/C23H27ClFN9S/c1-4-32(5-2)15-8-9-33(11-15)17-7-6-14(10-16(17)25)27-23-30-22(26)34(31-23)20-19-18(13(3)12-35-19)28-21(24)29-20/h6-7,10,12,15H,4-5,8-9,11H2,1-3H3,(H3,26,27,30,31)
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313168
PNG
(1-(6,7-dimethoxy-quinazolin-4-yl)-N3-(7-pyrrolidin...)
Show SMILES COc1cc2ncnc(-n3nc(Nc4ccc5CCC(CCc5c4)N4CCCC4)nc3N)c2cc1OC
Show InChI InChI=1S/C27H32N8O2/c1-36-23-14-21-22(15-24(23)37-2)29-16-30-25(21)35-26(28)32-27(33-35)31-19-8-5-17-6-9-20(10-7-18(17)13-19)34-11-3-4-12-34/h5,8,13-16,20H,3-4,6-7,9-12H2,1-2H3,(H3,28,31,32,33)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM312994
PNG
(N3-(3-chloro-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-...)
Show SMILES Nc1nc(Nc2ccc(OCCN3CCCC3)c(Cl)c2)nn1-c1ccccn1
Show InChI InChI=1S/C19H22ClN7O/c20-15-13-14(6-7-16(15)28-12-11-26-9-3-4-10-26)23-19-24-18(21)27(25-19)17-5-1-2-8-22-17/h1-2,5-8,13H,3-4,9-12H2,(H3,21,23,24,25)
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313062
PNG
(N3-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-1-(quinol...)
Show SMILES Nc1nc(Nc2ccc(OCCN3CCCC3)cc2)nn1-c1ccc2ccccc2n1
Show InChI InChI=1S/C23H25N7O/c24-22-27-23(28-30(22)21-12-7-17-5-1-2-6-20(17)26-21)25-18-8-10-19(11-9-18)31-16-15-29-13-3-4-14-29/h1-2,5-12H,3-4,13-16H2,(H3,24,25,27,28)
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313073
PNG
(1-(6-phenylthieno[3,2-d]pyrimidin-4-yl)-N3-(4-(2-(...)
Show SMILES Nc1nc(Nc2ccc(OCCN3CCCC3)cc2)nn1-c1ncnc2cc(sc12)-c1ccccc1
Show InChI InChI=1S/C26H26N8OS/c27-25-31-26(30-19-8-10-20(11-9-19)35-15-14-33-12-4-5-13-33)32-34(25)24-23-21(28-17-29-24)16-22(36-23)18-6-2-1-3-7-18/h1-3,6-11,16-17H,4-5,12-15H2,(H3,27,30,31,32)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313082
PNG
(1-(5,6,7,8-tetrahydrobenzo[4.,5]thieno[2,3-d]pyrim...)
Show SMILES Nc1nc(Nc2ccc(OCCN3CCCC3)cc2)nn1-c1ncnc2sc3CCCCc3c12
Show InChI InChI=1S/C24H28N8OS/c25-23-29-24(28-16-7-9-17(10-8-16)33-14-13-31-11-3-4-12-31)30-32(23)21-20-18-5-1-2-6-19(18)34-22(20)27-15-26-21/h7-10,15H,1-6,11-14H2,(H3,25,28,29,30)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313086
PNG
(1-(2-methylquinazolin-4-yl)-N3-(4-(2-(pyrrolidin-1...)
Show SMILES Cc1nc(-n2nc(Nc3ccc(OCCN4CCCC4)cc3)nc2N)c2ccccc2n1
Show InChI InChI=1S/C23H26N8O/c1-16-25-20-7-3-2-6-19(20)21(26-16)31-22(24)28-23(29-31)27-17-8-10-18(11-9-17)32-15-14-30-12-4-5-13-30/h2-3,6-11H,4-5,12-15H2,1H3,(H3,24,27,28,29)
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313098
PNG
(1-(6,7-dimethoxyisoquinolin-1-yl)-N3-(4-(2-(pyrrol...)
Show SMILES COc1cc2ccnc(-n3nc(Nc4ccc(OCCN5CCCC5)cc4)nc3N)c2cc1OC
Show InChI InChI=1S/C25H29N7O3/c1-33-21-15-17-9-10-27-23(20(17)16-22(21)34-2)32-24(26)29-25(30-32)28-18-5-7-19(8-6-18)35-14-13-31-11-3-4-12-31/h5-10,15-16H,3-4,11-14H2,1-2H3,(H3,26,28,29,30)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313103
PNG
(1-(2,6-dichlorothieno[3,2-d]pyrimidin-4-yl)-N3-(4-...)
Show SMILES Nc1nc(Nc2ccc(OCCN3CCCC3)cc2)nn1-c1nc(Cl)nc2cc(Cl)sc12
Show InChI InChI=1S/C20H20Cl2N8OS/c21-15-11-14-16(32-15)17(26-18(22)25-14)30-19(23)27-20(28-30)24-12-3-5-13(6-4-12)31-10-9-29-7-1-2-8-29/h3-6,11H,1-2,7-10H2,(H3,23,24,27,28)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313109
PNG
(1-(6-chloroquinazolin-4-yl)-N5-(4-(4-methylpiperaz...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2nc(N)nn2-c2ncnc3ccc(Cl)cc23)cc1
Show InChI InChI=1S/C21H22ClN9/c1-29-8-10-30(11-9-29)16-5-3-15(4-6-16)26-21-27-20(23)28-31(21)19-17-12-14(22)2-7-18(17)24-13-25-19/h2-7,12-13H,8-11H2,1H3,(H3,23,26,27,28)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313146
PNG
(1-(7-methyl-2-chlorothieno[3,2-d] pyrimidin-4-yl)-...)
Show SMILES Cc1csc2c(nc(Cl)nc12)-n1nc(Nc2ccc(cc2)C(=O)NCCN2CCCC2)nc1N
Show InChI InChI=1S/C22H24ClN9OS/c1-13-12-34-17-16(13)27-20(23)28-18(17)32-21(24)29-22(30-32)26-15-6-4-14(5-7-15)19(33)25-8-11-31-9-2-3-10-31/h4-7,12H,2-3,8-11H2,1H3,(H,25,33)(H3,24,26,29,30)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313162
PNG
(1-(7-methylthieno[3,2-d]pyrimidin-4-yl)-N3-(4-(1-(...)
Show SMILES Cc1csc2c(ncnc12)-n1nc(Nc2ccc(cc2)C2CCN(CC2)C2CC3CCC2C3)nc1N
Show InChI InChI=1S/C27H32N8S/c1-16-14-36-24-23(16)29-15-30-25(24)35-26(28)32-27(33-35)31-21-6-4-18(5-7-21)19-8-10-34(11-9-19)22-13-17-2-3-20(22)12-17/h4-7,14-15,17,19-20,22H,2-3,8-13H2,1H3,(H3,28,31,32,33)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM312999
PNG
(N3-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-1-(quinox...)
Show SMILES Nc1nc(Nc2ccc(OCCN3CCCC3)cc2)nn1-c1cnc2ccccc2n1
Show InChI InChI=1S/C22H24N8O/c23-21-27-22(28-30(21)20-15-24-18-5-1-2-6-19(18)26-20)25-16-7-9-17(10-8-16)31-14-13-29-11-3-4-12-29/h1-2,5-10,15H,3-4,11-14H2,(H3,23,25,27,28)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313066
PNG
(1-(6,7-dimethoxyquinazolin-4-yl)-N3-(4-(2-(pyrroli...)
Show SMILES COc1cc2ncnc(-n3nc(Nc4ccc(OCCN5CCCC5)cc4)nc3N)c2cc1OC
Show InChI InChI=1S/C24H28N8O3/c1-33-20-13-18-19(14-21(20)34-2)26-15-27-22(18)32-23(25)29-24(30-32)28-16-5-7-17(8-6-16)35-12-11-31-9-3-4-10-31/h5-8,13-15H,3-4,9-12H2,1-2H3,(H3,25,28,29,30)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313096
PNG
(1-(5,6-dihydrobenzo[h]cinnolin-3-yl)-N3-(4-(2-(pyr...)
Show SMILES Nc1nc(Nc2ccc(OCCN3CCCC3)cc2)nn1-c1cc2CCc3ccccc3-c2nn1
Show InChI InChI=1S/C26H28N8O/c27-25-29-26(28-20-9-11-21(12-10-20)35-16-15-33-13-3-4-14-33)32-34(25)23-17-19-8-7-18-5-1-2-6-22(18)24(19)31-30-23/h1-2,5-6,9-12,17H,3-4,7-8,13-16H2,(H3,27,28,29,32)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313104
PNG
(1-(2-chlorothieno[2,3-d]pyrimidin-4-yl)-N3-(4-(2-p...)
Show SMILES Nc1nc(Nc2ccc(OCCN3CCCC3)cc2)nn1-c1nc(Cl)nc2sccc12
Show InChI InChI=1S/C20H21ClN8OS/c21-18-24-16(15-7-12-31-17(15)25-18)29-19(22)26-20(27-29)23-13-3-5-14(6-4-13)30-11-10-28-8-1-2-9-28/h3-7,12H,1-2,8-11H2,(H3,22,23,26,27)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313105
PNG
(1-(2-chlorothieno[3,2-d]pyrimidin-4-yl)-N3-(4-(2-p...)
Show SMILES Nc1nc(Nc2ccc(OCCN3CCCC3)cc2)nn1-c1nc(Cl)nc2ccsc12
Show InChI InChI=1S/C20H21ClN8OS/c21-18-24-15-7-12-31-16(15)17(25-18)29-19(22)26-20(27-29)23-13-3-5-14(6-4-13)30-11-10-28-8-1-2-9-28/h3-7,12H,1-2,8-11H2,(H3,22,23,26,27)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313138
PNG
(4-(5-amino-3-(4-(1-methylpiperidin-4-yl)phenylamin...)
Show SMILES COc1cc2c(ncnc2cc1O)-n1nc(Nc2ccc(cc2)C2CCN(C)CC2)nc1N
Show InChI InChI=1S/C23H26N8O2/c1-30-9-7-15(8-10-30)14-3-5-16(6-4-14)27-23-28-22(24)31(29-23)21-17-11-20(33-2)19(32)12-18(17)25-13-26-21/h3-6,11-13,15,32H,7-10H2,1-2H3,(H3,24,27,28,29)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313158
PNG
(1-(2-chloro-6-methoxy-quinoxalin-3-yl)-N3-(3-fluor...)
Show SMILES COc1ccc2nc(Cl)c(nc2c1)-n1nc(Nc2ccc(N3CCC(CC3)N3CCCC3)c(F)c2)nc1N
Show InChI InChI=1S/C26H29ClFN9O/c1-38-18-5-6-20-21(15-18)32-24(23(27)31-20)37-25(29)33-26(34-37)30-16-4-7-22(19(28)14-16)36-12-8-17(9-13-36)35-10-2-3-11-35/h4-7,14-15,17H,2-3,8-13H2,1H3,(H3,29,30,33,34)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313167
PNG
(1-(7-methyl-2-chlorothieno[3,2-d] pyrimidin-4-yl)-...)
Show SMILES Cc1csc2c(nc(Cl)nc12)-n1nc(Nc2ccc3CCC(CCc3c2)N2CCCC2)nc1N
Show InChI InChI=1S/C24H27ClN8S/c1-14-13-34-20-19(14)28-22(25)29-21(20)33-23(26)30-24(31-33)27-17-7-4-15-5-8-18(9-6-16(15)12-17)32-10-2-3-11-32/h4,7,12-13,18H,2-3,5-6,8-11H2,1H3,(H3,26,27,30,31)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313016
PNG
(N-{2-[(4aR,6S,8aR)-2-amino-6-methyl-4,4a,5,6-tetra...)
Show SMILES Nc1nc(Nc2ccc(OCCN3CCCC3)cc2)nn1-c1cc(ccn1)C(F)(F)F
Show InChI InChI=1S/C20H22F3N7O/c21-20(22,23)14-7-8-25-17(13-14)30-18(24)27-19(28-30)26-15-3-5-16(6-4-15)31-12-11-29-9-1-2-10-29/h3-8,13H,1-2,9-12H2,(H3,24,26,27,28)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313027
PNG
(N-{2-[(4aR,6S,8aR)-2-amino-6-methyl-4,4a,5,6-tetra...)
Show SMILES Nc1nc(Nc2ccc(OCCN3CCCC3)cc2)nn1-c1nc(Cl)nc2ccccc12
Show InChI InChI=1S/C22H23ClN8O/c23-20-26-18-6-2-1-5-17(18)19(27-20)31-21(24)28-22(29-31)25-15-7-9-16(10-8-15)32-14-13-30-11-3-4-12-30/h1-2,5-10H,3-4,11-14H2,(H3,24,25,28,29)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313071
PNG
(1-(isoquinolin-1-yl)-N3-(4-(2-(pyrrolidin-1-yl)eth...)
Show SMILES Nc1nc(Nc2ccc(OCCN3CCCC3)cc2)nn1-c1nccc2ccccc12
Show InChI InChI=1S/C23H25N7O/c24-22-27-23(28-30(22)21-20-6-2-1-5-17(20)11-12-25-21)26-18-7-9-19(10-8-18)31-16-15-29-13-3-4-14-29/h1-2,5-12H,3-4,13-16H2,(H3,24,26,27,28)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313075
PNG
(N3-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-1-(thieno...)
Show SMILES Nc1nc(Nc2ccc(OCCN3CCCC3)cc2)nn1-c1ncnc2ccsc12
Show InChI InChI=1S/C20H22N8OS/c21-19-25-20(26-28(19)18-17-16(7-12-30-17)22-13-23-18)24-14-3-5-15(6-4-14)29-11-10-27-8-1-2-9-27/h3-7,12-13H,1-2,8-11H2,(H3,21,24,25,26)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313130
PNG
(N3-(3-fluoro-4-morpholinophenyl)-1-(isoquinolin-1-...)
Show SMILES Nc1nc(Nc2ccc(N3CCOCC3)c(F)c2)nn1-c1nccc2ccccc12
Show InChI InChI=1S/C21H20FN7O/c22-17-13-15(5-6-18(17)28-9-11-30-12-10-28)25-21-26-20(23)29(27-21)19-16-4-2-1-3-14(16)7-8-24-19/h1-8,13H,9-12H2,(H3,23,25,26,27)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313142
PNG
(1-(6,7-dimethoxyquinazolin-4-yl)-N3-(4-((4-methylp...)
Show SMILES COc1cc2ncnc(-n3nc(Nc4ccc(CN5CCN(C)CC5)cc4)nc3N)c2cc1OC
Show InChI InChI=1S/C24H29N9O2/c1-31-8-10-32(11-9-31)14-16-4-6-17(7-5-16)28-24-29-23(25)33(30-24)22-18-12-20(34-2)21(35-3)13-19(18)26-15-27-22/h4-7,12-13,15H,8-11,14H2,1-3H3,(H3,25,28,29,30)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313151
PNG
(1-(phenanthridin-6-yl)-N3-(4-(1-methylpiperidin-4-...)
Show SMILES CN1CCC(CC1)c1ccc(Nc2nc(N)n(n2)-c2nc3ccccc3c3ccccc23)cc1
Show InChI InChI=1S/C27H27N7/c1-33-16-14-19(15-17-33)18-10-12-20(13-11-18)29-27-31-26(28)34(32-27)25-23-8-3-2-6-21(23)22-7-4-5-9-24(22)30-25/h2-13,19H,14-17H2,1H3,(H3,28,29,31,32)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313152
PNG
(1-(phenanthridin-6-yl)-N3-(3-methyl-4-(4-pyrrolidi...)
Show SMILES Cc1cc(Nc2nc(N)n(n2)-c2nc3ccccc3c3ccccc23)ccc1N1CCC(CC1)N1CCCC1
Show InChI InChI=1S/C31H34N8/c1-21-20-22(12-13-28(21)38-18-14-23(15-19-38)37-16-6-7-17-37)33-31-35-30(32)39(36-31)29-26-10-3-2-8-24(26)25-9-4-5-11-27(25)34-29/h2-5,8-13,20,23H,6-7,14-19H2,1H3,(H3,32,33,35,36)
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313160
PNG
(1-(4-phenylpyridin-2-yl)-N3-(3-fluoro-4-(4-(pyrrol...)
Show SMILES Nc1nc(Nc2ccc(N3CCC(CC3)N3CCCC3)c(F)c2)nn1-c1cc(ccn1)-c1ccccc1
Show InChI InChI=1S/C28H31FN8/c29-24-19-22(8-9-25(24)36-16-11-23(12-17-36)35-14-4-5-15-35)32-28-33-27(30)37(34-28)26-18-21(10-13-31-26)20-6-2-1-3-7-20/h1-3,6-10,13,18-19,23H,4-5,11-12,14-17H2,(H3,30,32,33,34)
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313169
PNG
(1-(7-methyl-2-chlorothieno[3,2-d] pyrimidin-4-yl)-...)
Show SMILES CN(C1CC2CCC1C2)C1CCc2ccc(Nc3nc(N)n(n3)-c3nc(Cl)nc4c(C)csc34)cc2CC1
Show InChI InChI=1S/C28H33ClN8S/c1-15-14-38-24-23(15)32-26(29)33-25(24)37-27(30)34-28(35-37)31-20-8-5-17-6-9-21(10-7-18(17)13-20)36(2)22-12-16-3-4-19(22)11-16/h5,8,13-14,16,19,21-22H,3-4,6-7,9-12H2,1-2H3,(H3,30,31,34,35)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313171
PNG
(1-(6,7-dimethoxyquinazolin-4-yl)-N3-(7-(N-bicyclo[...)
Show SMILES COc1cc2ncnc(-n3nc(Nc4ccc5CCC(CCc5c4)NC4CC5CCC4C5)nc3N)c2cc1OC
Show InChI InChI=1S/C30H36N8O2/c1-39-26-14-23-25(15-27(26)40-2)32-16-33-28(23)38-29(31)36-30(37-38)35-22-10-6-18-5-8-21(9-7-19(18)13-22)34-24-12-17-3-4-20(24)11-17/h6,10,13-17,20-21,24,34H,3-5,7-9,11-12H2,1-2H3,(H3,31,35,36,37)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313079
PNG
(N3-(3-fluroo-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-...)
Show SMILES Nc1nc(Nc2ccc(OCCN3CCCC3)c(F)c2)nn1-c1nccc2ccccc12
Show InChI InChI=1S/C23H24FN7O/c24-19-15-17(7-8-20(19)32-14-13-30-11-3-4-12-30)27-23-28-22(25)31(29-23)21-18-6-2-1-5-16(18)9-10-26-21/h1-2,5-10,15H,3-4,11-14H2,(H3,25,27,28,29)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313080
PNG
(N3-(3-chloro-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-...)
Show SMILES COc1cc2ncnc(-n3nc(Nc4ccc(OCCN5CCCC5)c(Cl)c4)nc3N)c2cc1OC
Show InChI InChI=1S/C24H27ClN8O3/c1-34-20-12-16-18(13-21(20)35-2)27-14-28-22(16)33-23(26)30-24(31-33)29-15-5-6-19(17(25)11-15)36-10-9-32-7-3-4-8-32/h5-6,11-14H,3-4,7-10H2,1-2H3,(H3,26,29,30,31)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313081
PNG
(1-(2-chloro-7-methylthieno[3,2-d]pyrimidin-4-yl)-N...)
Show SMILES Cc1csc2c(nc(Cl)nc12)-n1nc(Nc2ccc(OCCN3CCCC3)cc2)nc1N
Show InChI InChI=1S/C21H23ClN8OS/c1-13-12-32-17-16(13)25-19(22)26-18(17)30-20(23)27-21(28-30)24-14-4-6-15(7-5-14)31-11-10-29-8-2-3-9-29/h4-7,12H,2-3,8-11H2,1H3,(H3,23,24,27,28)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313108
PNG
(N5-(4-(4-cyclohexylpiperazin-1-yl)phenyl)-1-(6,7-d...)
Show SMILES COc1cc2ncnc(-n3nc(N)nc3Nc3ccc(cc3)N3CCN(CC3)C3CCCCC3)c2cc1OC
Show InChI InChI=1S/C28H35N9O2/c1-38-24-16-22-23(17-25(24)39-2)30-18-31-26(22)37-28(33-27(29)34-37)32-19-8-10-21(11-9-19)36-14-12-35(13-15-36)20-6-4-3-5-7-20/h8-11,16-18,20H,3-7,12-15H2,1-2H3,(H3,29,32,33,34)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313133
PNG
(N3-(4-((R)-3-(dimethylamino) pyrrolidin-1-yl)pheny...)
Show SMILES CN(C)[C@@H]1CCN(C1)c1ccc(Nc2nc(N)n(n2)-c2nccc3ccccc23)cc1
Show InChI InChI=1S/C23H26N8/c1-29(2)19-12-14-30(15-19)18-9-7-17(8-10-18)26-23-27-22(24)31(28-23)21-20-6-4-3-5-16(20)11-13-25-21/h3-11,13,19H,12,14-15H2,1-2H3,(H3,24,26,27,28)/t19-/m1/s1
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313148
PNG
(1-(7-methyl-2-chlorothieno[3,2-d] pyrimidin-4-yl)-...)
Show SMILES Cc1csc2c(nc(Cl)nc12)-n1nc(Nc2ccc(N3CCC(CC3)N3CCCCC3)c(F)c2)nc1N
Show InChI InChI=1S/C25H29ClFN9S/c1-15-14-37-21-20(15)30-23(26)31-22(21)36-24(28)32-25(33-36)29-16-5-6-19(18(27)13-16)35-11-7-17(8-12-35)34-9-3-2-4-10-34/h5-6,13-14,17H,2-4,7-12H2,1H3,(H3,28,29,32,33)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313009
PNG
(N-{2-[(4aR,6S,8aR)-2-amino-6-methyl-4,4a,5,6-tetra...)
Show SMILES Nc1nc(Nc2ccc(OCCN3CCCCC3)cc2)nn1-c1cccc(Cl)n1
Show InChI InChI=1S/C20H24ClN7O/c21-17-5-4-6-18(24-17)28-19(22)25-20(26-28)23-15-7-9-16(10-8-15)29-14-13-27-11-2-1-3-12-27/h4-10H,1-3,11-14H2,(H3,22,23,25,26)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313011
PNG
(N-{2-[(4aR,6S,8aR)-2-amino-6-methyl-4,4a,5,6-tetra...)
Show SMILES CC1CCCN1CCOc1ccc(Nc2nc(N)n(n2)-c2cnc3ccccc3n2)cc1
Show InChI InChI=1S/C23H26N8O/c1-16-5-4-12-30(16)13-14-32-18-10-8-17(9-11-18)26-23-28-22(24)31(29-23)21-15-25-19-6-2-3-7-20(19)27-21/h2-3,6-11,15-16H,4-5,12-14H2,1H3,(H3,24,26,28,29)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313076
PNG
(N3-(3-fluoro-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-...)
Show SMILES Nc1nc(Nc2ccc(OCCN3CCCC3)c(F)c2)nn1-c1cnc2ccccc2n1
Show InChI InChI=1S/C22H23FN8O/c23-16-13-15(7-8-19(16)32-12-11-30-9-3-4-10-30)26-22-28-21(24)31(29-22)20-14-25-17-5-1-2-6-18(17)27-20/h1-2,5-8,13-14H,3-4,9-12H2,(H3,24,26,28,29)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313088
PNG
(N3-(3-chloro-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-...)
Show SMILES Nc1nc(Nc2ccc(OCCN3CCCC3)c(Cl)c2)nn1-c1ncnc2sc3CCCCc3c12
Show InChI InChI=1S/C24H27ClN8OS/c25-17-13-15(7-8-18(17)34-12-11-32-9-3-4-10-32)29-24-30-23(26)33(31-24)21-20-16-5-1-2-6-19(16)35-22(20)28-14-27-21/h7-8,13-14H,1-6,9-12H2,(H3,26,29,30,31)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313127
PNG
(1-(6,7-dimethoxyquinazolin-4-yl)-N3-(4-morpholinop...)
Show SMILES COc1cc2ncnc(-n3nc(Nc4ccc(cc4)N4CCOCC4)nc3N)c2cc1OC
Show InChI InChI=1S/C22H24N8O3/c1-31-18-11-16-17(12-19(18)32-2)24-13-25-20(16)30-21(23)27-22(28-30)26-14-3-5-15(6-4-14)29-7-9-33-10-8-29/h3-6,11-13H,7-10H2,1-2H3,(H3,23,26,27,28)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313134
PNG
(N3-(4-((S)-3-(dimethylamino) pyrrolidin-1-yl)pheny...)
Show SMILES CN(C)[C@H]1CCN(C1)c1ccc(Nc2nc(N)n(n2)-c2nccc3ccccc23)cc1
Show InChI InChI=1S/C23H26N8/c1-29(2)19-12-14-30(15-19)18-9-7-17(8-10-18)26-23-27-22(24)31(28-23)21-20-6-4-3-5-16(20)11-13-25-21/h3-11,13,19H,12,14-15H2,1-2H3,(H3,24,26,27,28)/t19-/m0/s1
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313161
PNG
(1-(7-methylthieno[3,2-d]pyrimidin-4-yl)-N3-(3-fluo...)
Show SMILES Cc1csc2c(ncnc12)-n1nc(Nc2ccc(N3CCC(CC3)N3CC4CCC3C4)c(F)c2)nc1N
Show InChI InChI=1S/C26H30FN9S/c1-15-13-37-23-22(15)29-14-30-24(23)36-25(28)32-26(33-36)31-17-3-5-21(20(27)11-17)34-8-6-18(7-9-34)35-12-16-2-4-19(35)10-16/h3,5,11,13-14,16,18-19H,2,4,6-10,12H2,1H3,(H3,28,31,32,33)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313172
PNG
(1-(6,7-dimethoxy-quinazolin-4-yl)-N3-(7-(N-methyl-...)
Show SMILES COc1cc2ncnc(-n3nc(Nc4ccc5CCC(CCc5c4)N(C)C4CC5CCC4C5)nc3N)c2cc1OC
Show InChI InChI=1S/C31H38N8O2/c1-38(26-13-18-4-5-21(26)12-18)23-10-7-19-6-9-22(14-20(19)8-11-23)35-31-36-30(32)39(37-31)29-24-15-27(40-2)28(41-3)16-25(24)33-17-34-29/h6,9,14-18,21,23,26H,4-5,7-8,10-13H2,1-3H3,(H3,32,35,36,37)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313029
PNG
(N-{2-[(4aR,6S,8aR)-2-amino-6-methyl-4,4a,5,6-tetra...)
Show SMILES Nc1nc(Nc2ccc(OCCN3CCCC3)c(Cl)c2)nn1-c1nc2ccccc2s1
Show InChI InChI=1S/C21H22ClN7OS/c22-15-13-14(7-8-17(15)30-12-11-28-9-3-4-10-28)24-20-26-19(23)29(27-20)21-25-16-5-1-2-6-18(16)31-21/h1-2,5-8,13H,3-4,9-12H2,(H3,23,24,26,27)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313065
PNG
(1-(2-chloro-6,7-dimethoxyquinazolin-4-yl)-N3-(4-(2...)
Show SMILES COc1cc2nc(Cl)nc(-n3nc(Nc4ccc(OCCN5CCCC5)cc4)nc3N)c2cc1OC
Show InChI InChI=1S/C24H27ClN8O3/c1-34-19-13-17-18(14-20(19)35-2)28-22(25)29-21(17)33-23(26)30-24(31-33)27-15-5-7-16(8-6-15)36-12-11-32-9-3-4-10-32/h5-8,13-14H,3-4,9-12H2,1-2H3,(H3,26,27,30,31)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313067
PNG
(N3-(4-(2-(2,5-dimethylpyrrolidin-1-yl)ethoxy)pheny...)
Show SMILES CC1CCC(C)N1CCOc1ccc(Nc2nc(N)n(n2)-c2cnc3ccccc3n2)cc1
Show InChI InChI=1S/C24H28N8O/c1-16-7-8-17(2)31(16)13-14-33-19-11-9-18(10-12-19)27-24-29-23(25)32(30-24)22-15-26-20-5-3-4-6-21(20)28-22/h3-6,9-12,15-17H,7-8,13-14H2,1-2H3,(H3,25,27,29,30)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313069
PNG
(1-(6-chloroquinazolin-4-yl)-N3-(4-(2-(pyrrolidin-1...)
Show SMILES Nc1nc(Nc2ccc(OCCN3CCCC3)cc2)nn1-c1ncnc2ccc(Cl)cc12
Show InChI InChI=1S/C22H23ClN8O/c23-15-3-8-19-18(13-15)20(26-14-25-19)31-21(24)28-22(29-31)27-16-4-6-17(7-5-16)32-12-11-30-9-1-2-10-30/h3-8,13-14H,1-2,9-12H2,(H3,24,27,28,29)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313070
PNG
(1-(2-chloro-6,7-dihydro-5H-cyclopenta[d]pyrimidin-...)
Show SMILES Nc1nc(Nc2ccc(OCCN3CCCC3)cc2)nn1-c1nc(Cl)nc2CCCc12
Show InChI InChI=1S/C21H25ClN8O/c22-19-25-17-5-3-4-16(17)18(26-19)30-20(23)27-21(28-30)24-14-6-8-15(9-7-14)31-13-12-29-10-1-2-11-29/h6-9H,1-5,10-13H2,(H3,23,24,27,28)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313072
PNG
(N3-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-1-(thieno...)
Show SMILES Nc1nc(Nc2ccc(OCCN3CCCC3)cc2)nn1-c1ncnc2sccc12
Show InChI InChI=1S/C20H22N8OS/c21-19-25-20(26-28(19)17-16-7-12-30-18(16)23-13-22-17)24-14-3-5-15(6-4-14)29-11-10-27-8-1-2-9-27/h3-7,12-13H,1-2,8-11H2,(H3,21,24,25,26)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313077
PNG
(1-(benzo[d]thiazol-2-yl)-N3-(3-fluoro-4-(2-(pyrrol...)
Show SMILES Nc1nc(Nc2ccc(OCCN3CCCC3)c(F)c2)nn1-c1nc2ccccc2s1
Show InChI InChI=1S/C21H22FN7OS/c22-15-13-14(7-8-17(15)30-12-11-28-9-3-4-10-28)24-20-26-19(23)29(27-20)21-25-16-5-1-2-6-18(16)31-21/h1-2,5-8,13H,3-4,9-12H2,(H3,23,24,26,27)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313087
PNG
(1-(6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyri...)
Show SMILES Nc1nc(Nc2ccc(OCCN3CCCC3)cc2)nn1-c1ncnc2sc3CCCc3c12
Show InChI InChI=1S/C23H26N8OS/c24-22-28-23(27-15-6-8-16(9-7-15)32-13-12-30-10-1-2-11-30)29-31(22)20-19-17-4-3-5-18(17)33-21(19)26-14-25-20/h6-9,14H,1-5,10-13H2,(H3,24,27,28,29)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313089
PNG
(N3-(3-fluoro-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-...)
Show SMILES Nc1nc(Nc2ccc(OCCN3CCCC3)c(F)c2)nn1-c1ncnc2sc3CCCCc3c12
Show InChI InChI=1S/C24H27FN8OS/c25-17-13-15(7-8-18(17)34-12-11-32-9-3-4-10-32)29-24-30-23(26)33(31-24)21-20-16-5-1-2-6-19(16)35-22(20)28-14-27-21/h7-8,13-14H,1-6,9-12H2,(H3,26,29,30,31)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313090
PNG
(1-(furo[3,2-c]pyridin-4-yl)-N3-(4-(2-(pyrrolidin-1...)
Show SMILES Nc1nc(Nc2ccc(OCCN3CCCC3)cc2)nn1-c1nccc2occc12
Show InChI InChI=1S/C21H23N7O2/c22-20-25-21(26-28(20)19-17-8-13-30-18(17)7-9-23-19)24-15-3-5-16(6-4-15)29-14-12-27-10-1-2-11-27/h3-9,13H,1-2,10-12,14H2,(H3,22,24,25,26)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313111
PNG
(N5-(4-(4-(bicyclo[2.2.1]heptan-2-yl)piperazin-1-yl...)
Show SMILES COc1cc2ncnc(-n3nc(N)nc3Nc3ccc(cc3)N3CCN(CC3)C3CC4CCC3C4)c2cc1OC
Show InChI InChI=1S/C29H35N9O2/c1-39-25-15-22-23(16-26(25)40-2)31-17-32-27(22)38-29(34-28(30)35-38)33-20-5-7-21(8-6-20)36-9-11-37(12-10-36)24-14-18-3-4-19(24)13-18/h5-8,15-19,24H,3-4,9-14H2,1-2H3,(H3,30,33,34,35)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313113
PNG
(1-(phenanthridin-6-yl)-N5-(3-fluoro-4-(4-cyclopent...)
Show SMILES Nc1nc(Nc2ccc(N3CCN(CC3)C3CCCC3)c(F)c2)n(n1)-c1nc2ccccc2c2ccccc12
Show InChI InChI=1S/C30H31FN8/c31-25-19-20(13-14-27(25)38-17-15-37(16-18-38)21-7-1-2-8-21)33-30-35-29(32)36-39(30)28-24-11-4-3-9-22(24)23-10-5-6-12-26(23)34-28/h3-6,9-14,19,21H,1-2,7-8,15-18H2,(H3,32,33,35,36)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313124
PNG
(1-(6,7-dimethoxyquinazolin-4-yl)-N3-(4-(1-methylpi...)
Show SMILES COc1cc2ncnc(-n3nc(Nc4ccc(OC5CCCN(C)C5)cc4)nc3N)c2cc1OC
Show InChI InChI=1S/C24H28N8O3/c1-31-10-4-5-17(13-31)35-16-8-6-15(7-9-16)28-24-29-23(25)32(30-24)22-18-11-20(33-2)21(34-3)12-19(18)26-14-27-22/h6-9,11-12,14,17H,4-5,10,13H2,1-3H3,(H3,25,28,29,30)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313125
PNG
(1-(isoquinolin-1-yl)-N3-(4-(1-methylpiperidin-3-yl...)
Show SMILES CN1CCCC(C1)Oc1ccc(Nc2nc(N)n(n2)-c2nccc3ccccc23)cc1
Show InChI InChI=1S/C23H25N7O/c1-29-14-4-6-19(15-29)31-18-10-8-17(9-11-18)26-23-27-22(24)30(28-23)21-20-7-3-2-5-16(20)12-13-25-21/h2-3,5,7-13,19H,4,6,14-15H2,1H3,(H3,24,26,27,28)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313140
PNG
(1-(6,7-dimethoxyquinazolin-4-yl)-N3-(4-((S)-3-(dim...)
Show SMILES COc1cc2ncnc(-n3nc(Nc4ccc(cc4)N4CC[C@@H](C4)N(C)C)nc3N)c2cc1OC
Show InChI InChI=1S/C24H29N9O2/c1-31(2)17-9-10-32(13-17)16-7-5-15(6-8-16)28-24-29-23(25)33(30-24)22-18-11-20(34-3)21(35-4)12-19(18)26-14-27-22/h5-8,11-12,14,17H,9-10,13H2,1-4H3,(H3,25,28,29,30)/t17-/m0/s1
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313147
PNG
(1-(6,7-dimethoxyquinazolin-4-yl)-N3-(3-fluoro-4-(4...)
Show SMILES COc1cc2ncnc(-n3nc(Nc4ccc(N5CCC(CC5)N5CCCCC5)c(F)c4)nc3N)c2cc1OC
Show InChI InChI=1S/C28H34FN9O2/c1-39-24-15-20-22(16-25(24)40-2)31-17-32-26(20)38-27(30)34-28(35-38)33-18-6-7-23(21(29)14-18)37-12-8-19(9-13-37)36-10-4-3-5-11-36/h6-7,14-17,19H,3-5,8-13H2,1-2H3,(H3,30,33,34,35)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313163
PNG
(1-(7-methylthieno[3,2-d]pyrimidin-4-yl)-N3-(3-fluo...)
Show SMILES Cc1csc2c(ncnc12)-n1nc(Nc2ccccc2C2CCN(CC2F)[C@H]2C[C@@H]3CC[C@H]2C3)nc1N
Show InChI InChI=1S/C27H31FN8S/c1-15-13-37-24-23(15)30-14-31-25(24)36-26(29)33-27(34-36)32-21-5-3-2-4-19(21)18-8-9-35(12-20(18)28)22-11-16-6-7-17(22)10-16/h2-5,13-14,16-18,20,22H,6-12H2,1H3,(H3,29,32,33,34)/t16-,17+,18?,20?,22+/m1/s1
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313170
PNG
(1-(7-methyl-2-chlorothieno[3,2-d] pyrimidin-4-yl)-...)
Show SMILES Cc1csc2c(nc(Cl)nc12)-n1nc(Nc2ccc3CCC(CCc3c2)NC2CC3CCC2C3)nc1N
Show InChI InChI=1S/C27H31ClN8S/c1-14-13-37-23-22(14)32-25(28)33-24(23)36-26(29)34-27(35-36)31-20-9-5-16-4-7-19(8-6-17(16)12-20)30-21-11-15-2-3-18(21)10-15/h5,9,12-13,15,18-19,21,30H,2-4,6-8,10-11H2,1H3,(H3,29,31,34,35)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313030
PNG
(N-{2-[(4aR,6S,8aR)-2-amino-6-methyl-4,4a,5,6-tetra...)
Show SMILES Cn1c(nc2ccccc12)-n1nc(Nc2ccc(OCCN3CCCC3)c(Cl)c2)nc1N
Show InChI InChI=1S/C22H25ClN8O/c1-29-18-7-3-2-6-17(18)26-22(29)31-20(24)27-21(28-31)25-15-8-9-19(16(23)14-15)32-13-12-30-10-4-5-11-30/h2-3,6-9,14H,4-5,10-13H2,1H3,(H3,24,25,27,28)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313074
PNG
(N3-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-1-(2-(tri...)
Show SMILES Nc1nc(Nc2ccc(OCCN3CCCC3)cc2)nn1-c1nc(nc2ccccc12)C(F)(F)F
Show InChI InChI=1S/C23H23F3N8O/c24-23(25,26)20-29-18-6-2-1-5-17(18)19(30-20)34-21(27)31-22(32-34)28-15-7-9-16(10-8-15)35-14-13-33-11-3-4-12-33/h1-2,5-10H,3-4,11-14H2,(H3,27,28,31,32)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313106
PNG
(N3-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-1-(6,7,8,...)
Show SMILES Nc1nc(Nc2ccc(OCCN3CCCC3)cc2)nn1-c1ncnc2sc3CCCCCc3c12
Show InChI InChI=1S/C25H30N8OS/c26-24-30-25(29-17-8-10-18(11-9-17)34-15-14-32-12-4-5-13-32)31-33(24)22-21-19-6-2-1-3-7-20(19)35-23(21)28-16-27-22/h8-11,16H,1-7,12-15H2,(H3,26,29,30,31)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313023
PNG
(N-{2-[(4aR,6S,8aR)-2-amino-6-methyl-4,4a,5,6-tetra...)
Show SMILES COC(=O)C1CCCN1CCOc1ccc(Nc2nc(N)n(n2)-c2cnc3ccccc3n2)cc1
Show InChI InChI=1S/C24H26N8O3/c1-34-22(33)20-7-4-12-31(20)13-14-35-17-10-8-16(9-11-17)27-24-29-23(25)32(30-24)21-15-26-18-5-2-3-6-19(18)28-21/h2-3,5-6,8-11,15,20H,4,7,12-14H2,1H3,(H3,25,27,29,30)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313112
PNG
(1-(6-(1,1-dimethylethyl)thieno[3,2-d]pyrimidin-4-y...)
Show SMILES CC(C)(C)c1cc2ncnc(-n3nc(N)nc3Nc3ccc(cc3)N3CCN(CC3)C3CC4CCC3C4)c2s1
Show InChI InChI=1S/C29H37N9S/c1-29(2,3)24-16-22-25(39-24)26(32-17-31-22)38-28(34-27(30)35-38)33-20-6-8-21(9-7-20)36-10-12-37(13-11-36)23-15-18-4-5-19(23)14-18/h6-9,16-19,23H,4-5,10-15H2,1-3H3,(H3,30,33,34,35)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313150
PNG
(1-(8-methoxy-5,5-dimethyl-5H-chromeno[4,3-c] pyrid...)
Show SMILES COc1ccc-2c(OC(C)(C)c3cc(nnc-23)-n2nc(Nc3ccc(N4CCC(CC4)N4CCN(C)CC4)c(F)c3)nc2N)c1
Show InChI InChI=1S/C32H39FN10O2/c1-32(2)24-19-28(37-38-29(24)23-7-6-22(44-4)18-27(23)45-32)43-30(34)36-31(39-43)35-20-5-8-26(25(33)17-20)42-11-9-21(10-12-42)41-15-13-40(3)14-16-41/h5-8,17-19,21H,9-16H2,1-4H3,(H3,34,35,36,39)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313019
PNG
(N-{2-[(4aR,6S,8aR)-2-amino-6-methyl-4,4a,5,6-tetra...)
Show SMILES Nc1nc(Nc2ccc(OCCN3CCCC3)cc2)nn1-c1ncccc1C(F)(F)F
Show InChI InChI=1S/C20H22F3N7O/c21-20(22,23)16-4-3-9-25-17(16)30-18(24)27-19(28-30)26-14-5-7-15(8-6-14)31-13-12-29-10-1-2-11-29/h3-9H,1-2,10-13H2,(H3,24,26,27,28)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313091
PNG
(1-(2-methyl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3...)
Show SMILES Cc1nc(-n2nc(Nc3ccc(OCCN4CCCC4)cc3)nc2N)c2c3CCCCc3sc2n1
Show InChI InChI=1S/C25H30N8OS/c1-16-27-22(21-19-6-2-3-7-20(19)35-23(21)28-16)33-24(26)30-25(31-33)29-17-8-10-18(11-9-17)34-15-14-32-12-4-5-13-32/h8-11H,2-7,12-15H2,1H3,(H3,26,29,30,31)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313095
PNG
(1-(5,6,6a,7,8,9,10,10a-octahydrobenzo[h]quinazolin...)
Show SMILES Nc1nc(Nc2ccc(OCCN3CCCC3)cc2)nn1-c1ncc2CCC3CCCCC3c2n1
Show InChI InChI=1S/C26H34N8O/c27-24-31-25(29-20-9-11-21(12-10-20)35-16-15-33-13-3-4-14-33)32-34(24)26-28-17-19-8-7-18-5-1-2-6-22(18)23(19)30-26/h9-12,17-18,22H,1-8,13-16H2,(H3,27,29,31,32)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313117
PNG
((S)-ethyl 4-(5-amino-1-(2-(2-(pyrrolidin-1-ylmeth...)
Show SMILES CCOC(=O)c1ccc(Nc2nc(N)n(n2)-c2ccnc(c2)N2CCC[C@H]2CN2CCCC2)cc1
Show InChI InChI=1S/C25H32N8O2/c1-2-35-23(34)18-7-9-19(10-8-18)28-25-29-24(26)33(30-25)20-11-12-27-22(16-20)32-15-5-6-21(32)17-31-13-3-4-14-31/h7-12,16,21H,2-6,13-15,17H2,1H3,(H3,26,28,29,30)/t21-/m0/s1
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313139
PNG
(1-(5,6-dihydrobenzo[h] cinnolin-3-yl)-N3-(3-fluoro...)
Show SMILES Nc1nc(Nc2ccc(N3CCC(CC3)N3CCCC3)c(F)c2)nn1-c1cc2CCc3ccccc3-c2nn1
Show InChI InChI=1S/C29H32FN9/c30-24-18-21(9-10-25(24)38-15-11-22(12-16-38)37-13-3-4-14-37)32-29-33-28(31)39(36-29)26-17-20-8-7-19-5-1-2-6-23(19)27(20)35-34-26/h1-2,5-6,9-10,17-18,22H,3-4,7-8,11-16H2,(H3,31,32,33,36)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313159
PNG
(1-(6-phenylpyridazin-3-yl)-N3-(3-fluoro-4-(4-(pyrr...)
Show SMILES Nc1nc(Nc2ccc(N3CCC(CC3)N3CCCC3)c(F)c2)nn1-c1ccc(nn1)-c1ccccc1
Show InChI InChI=1S/C27H30FN9/c28-22-18-20(8-10-24(22)36-16-12-21(13-17-36)35-14-4-5-15-35)30-27-31-26(29)37(34-27)25-11-9-23(32-33-25)19-6-2-1-3-7-19/h1-3,6-11,18,21H,4-5,12-17H2,(H3,29,30,31,34)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313007
PNG
(N-{2-[(4aR,6S,8aR)-2-amino-6-methyl-4,4a,5,6-tetra...)
Show SMILES Nc1nc(Nc2ccc(OCCN3CCCC3)cc2)nn1-c1ccc(Cl)cn1
Show InChI InChI=1S/C19H22ClN7O/c20-14-3-8-17(22-13-14)27-18(21)24-19(25-27)23-15-4-6-16(7-5-15)28-12-11-26-9-1-2-10-26/h3-8,13H,1-2,9-12H2,(H3,21,23,24,25)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313020
PNG
(N-{2-[(4aR,6S,8aR)-2-amino-6-methyl-4,4a,5,6-tetra...)
Show SMILES COc1cccc(n1)-n1nc(Nc2ccc(OCCN3CCCC3)cc2)nc1N
Show InChI InChI=1S/C20H25N7O2/c1-28-18-6-4-5-17(23-18)27-19(21)24-20(25-27)22-15-7-9-16(10-8-15)29-14-13-26-11-2-3-12-26/h4-10H,2-3,11-14H2,1H3,(H3,21,22,24,25)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313093
PNG
(1-(5,6-dihydrobenzo[h]quinazolin-2-yl)-N3-(4-(2-(p...)
Show SMILES Nc1nc(Nc2ccc(OCCN3CCCC3)cc2)nn1-c1ncc2CCc3ccccc3-c2n1
Show InChI InChI=1S/C26H28N8O/c27-24-31-25(29-20-9-11-21(12-10-20)35-16-15-33-13-3-4-14-33)32-34(24)26-28-17-19-8-7-18-5-1-2-6-22(18)23(19)30-26/h1-2,5-6,9-12,17H,3-4,7-8,13-16H2,(H3,27,29,31,32)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313126
PNG
(1-(isoquinolin-1-yl)-N3-(4-morpholinophenyl)-1H-1,...)
Show SMILES Nc1nc(Nc2ccc(cc2)N2CCOCC2)nn1-c1nccc2ccccc12
Show InChI InChI=1S/C21H21N7O/c22-20-25-21(24-16-5-7-17(8-6-16)27-11-13-29-14-12-27)26-28(20)19-18-4-2-1-3-15(18)9-10-23-19/h1-10H,11-14H2,(H3,22,24,25,26)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313164
PNG
(N5-(4-((1-methylpyrrolidin-2-yl)methoxy)phenyl)-1-...)
Show SMILES CN1CCCC1COc1ccc(Nc2nc(N)nn2-c2cnc3ccccc3n2)cc1
Show InChI InChI=1S/C22H24N8O/c1-29-12-4-5-16(29)14-31-17-10-8-15(9-11-17)25-22-27-21(23)28-30(22)20-13-24-18-6-2-3-7-19(18)26-20/h2-3,6-11,13,16H,4-5,12,14H2,1H3,(H3,23,25,27,28)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313031
PNG
(1-(6-chloropyridazin-3-yl)-N3-(4-(2-(pyrrolidin-1-...)
Show SMILES Nc1nc(Nc2ccc(OCCN3CCCC3)cc2)nn1-c1ccc(Cl)nn1
Show InChI InChI=1S/C18H21ClN8O/c19-15-7-8-16(24-23-15)27-17(20)22-18(25-27)21-13-3-5-14(6-4-13)28-12-11-26-9-1-2-10-26/h3-8H,1-2,9-12H2,(H3,20,21,22,25)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313025
PNG
(N-{2-[(4aR,6S,8aR)-2-amino-6-methyl-4,4a,5,6-tetra...)
Show SMILES CNc1cccc(n1)-n1nc(Nc2ccc(OCCN3CCCCC3)cc2)nc1N
Show InChI InChI=1S/C21H28N8O/c1-23-18-6-5-7-19(25-18)29-20(22)26-21(27-29)24-16-8-10-17(11-9-16)30-15-14-28-12-3-2-4-13-28/h5-11H,2-4,12-15H2,1H3,(H,23,25)(H3,22,24,26,27)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313100
PNG
(US10166216, Compound 79 | benzyl 3-(5-amino-3-(4-(...)
Show SMILES Nc1nc(Nc2ccc(OCCN3CCCC3)cc2)nn1-c1cc2CN(CCc2nn1)C(=O)OCc1ccccc1
Show InChI InChI=1S/C29H33N9O3/c30-27-32-28(31-23-8-10-24(11-9-23)40-17-16-36-13-4-5-14-36)35-38(27)26-18-22-19-37(15-12-25(22)33-34-26)29(39)41-20-21-6-2-1-3-7-21/h1-3,6-11,18H,4-5,12-17,19-20H2,(H3,30,31,32,35)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313120
PNG
(1-(pyridin-2-yl)-N3-(3,4,5-trimethoxyphenyl)-1H-1,...)
Show SMILES COc1cc(Nc2nc(N)n(n2)-c2ccccn2)cc(OC)c1OC
Show InChI InChI=1S/C16H18N6O3/c1-23-11-8-10(9-12(24-2)14(11)25-3)19-16-20-15(17)22(21-16)13-6-4-5-7-18-13/h4-9H,1-3H3,(H3,17,19,20,21)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313165
PNG
(1-(6,7-dimethoxyquinazolin-4-yl)-N5-(4-(1-methylpi...)
Show SMILES COc1cc2ncnc(-n3nc(N)nc3Nc3ccc(OC4CCCN(C)C4)cc3)c2cc1OC
Show InChI InChI=1S/C24H28N8O3/c1-31-10-4-5-17(13-31)35-16-8-6-15(7-9-16)28-24-29-23(25)30-32(24)22-18-11-20(33-2)21(34-3)12-19(18)26-14-27-22/h6-9,11-12,14,17H,4-5,10,13H2,1-3H3,(H3,25,28,29,30)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313173
PNG
(1-(7-methyl-2-chlorothieno[3,2-d] pyrimidin-4-yl)-...)
Show SMILES CCN(CC)CCC1CCCc2ccc(Nc3nc(N)n(n3)-c3nc(Cl)nc4c(C)csc34)cc2C1O
Show InChI InChI=1S/C26H33ClN8OS/c1-4-34(5-2)12-11-17-8-6-7-16-9-10-18(13-19(16)21(17)36)29-26-32-25(28)35(33-26)23-22-20(15(3)14-37-22)30-24(27)31-23/h9-10,13-14,17,21,36H,4-8,11-12H2,1-3H3,(H3,28,29,32,33)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM312997
PNG
(N3-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-1-(4-(tri...)
Show SMILES Nc1nc(Nc2ccc(OCCN3CCCC3)cc2)nn1-c1nccc(n1)C(F)(F)F
Show InChI InChI=1S/C19H21F3N8O/c20-19(21,22)15-7-8-24-18(26-15)30-16(23)27-17(28-30)25-13-3-5-14(6-4-13)31-12-11-29-9-1-2-10-29/h3-8H,1-2,9-12H2,(H3,23,25,27,28)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313003
PNG
(N-{2-[(4aR,6S,8aR)-2-amino-6-methyl-4,4a,5,6-tetra...)
Show SMILES Nc1nc(Nc2ccc(OCCN3CCCC3)cc2)nn1-c1cnccn1
Show InChI InChI=1S/C18H22N8O/c19-17-23-18(24-26(17)16-13-20-7-8-21-16)22-14-3-5-15(6-4-14)27-12-11-25-9-1-2-10-25/h3-8,13H,1-2,9-12H2,(H3,19,22,23,24)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313006
PNG
(N-{2-[(4aR,6S,8aR)-2-amino-6-methyl-4,4a,5,6-tetra...)
Show SMILES Nc1nc(Nc2ccc(OCCN3CCCC3)cc2)nn1-c1cccc(Cl)n1
Show InChI InChI=1S/C19H22ClN7O/c20-16-4-3-5-17(23-16)27-18(21)24-19(25-27)22-14-6-8-15(9-7-14)28-13-12-26-10-1-2-11-26/h3-9H,1-2,10-13H2,(H3,21,22,24,25)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313028
PNG
(N-{2-[(4aR,6S,8aR)-2-amino-6-methyl-4,4a,5,6-tetra...)
Show SMILES Nc1nc(Nc2ccc(OCCN3CCCC3)cc2)nn1-c1nc(nc2ccccc12)N1CCOCC1
Show InChI InChI=1S/C26H31N9O2/c27-24-31-25(28-19-7-9-20(10-8-19)37-18-13-33-11-3-4-12-33)32-35(24)23-21-5-1-2-6-22(21)29-26(30-23)34-14-16-36-17-15-34/h1-2,5-10H,3-4,11-18H2,(H3,27,28,31,32)
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313094
PNG
(1-(7-tert-butyl-5,6,7,8-tetrahydrobenzo[4,5]thieno...)
Show SMILES CC(C)(C)C1CCc2c(C1)sc1ncnc(-n3nc(Nc4ccc(OCCN5CCCC5)cc4)nc3N)c21
Show InChI InChI=1S/C28H36N8OS/c1-28(2,3)18-6-11-21-22(16-18)38-25-23(21)24(30-17-31-25)36-26(29)33-27(34-36)32-19-7-9-20(10-8-19)37-15-14-35-12-4-5-13-35/h7-10,17-18H,4-6,11-16H2,1-3H3,(H3,29,32,33,34)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313101
PNG
(N3-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-1-(5,6,7,...)
Show SMILES Nc1nc(Nc2ccc(OCCN3CCCC3)cc2)nn1-c1cc2CNCCc2nn1
Show InChI InChI=1S/C21H27N9O/c22-20-25-21(28-30(20)19-13-15-14-23-8-7-18(15)26-27-19)24-16-3-5-17(6-4-16)31-12-11-29-9-1-2-10-29/h3-6,13,23H,1-2,7-12,14H2,(H3,22,24,25,28)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM312995
PNG
(1-(pyridin-2-yl)-N3-(4-(2-(pyrrolidin-1-yl)ethoxy)...)
Show SMILES Nc1nc(Nc2ccc(OCCN3CCCC3)cc2)nn1-c1ccccn1
Show InChI InChI=1S/C19H23N7O/c20-18-23-19(24-26(18)17-5-1-2-10-21-17)22-15-6-8-16(9-7-15)27-14-13-25-11-3-4-12-25/h1-2,5-10H,3-4,11-14H2,(H3,20,22,23,24)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313129
PNG
(N3-(3-chloro-4-morpholinophenyl)-1-(6-chloroquinaz...)
Show SMILES Nc1nc(Nc2ccc(N3CCOCC3)c(Cl)c2)nn1-c1ncnc2ccc(Cl)cc12
Show InChI InChI=1S/C20H18Cl2N8O/c21-12-1-3-16-14(9-12)18(25-11-24-16)30-19(23)27-20(28-30)26-13-2-4-17(15(22)10-13)29-5-7-31-8-6-29/h1-4,9-11H,5-8H2,(H3,23,26,27,28)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313010
PNG
(N-{2-[(4aR,6S,8aR)-2-amino-6-methyl-4,4a,5,6-tetra...)
Show SMILES Nc1nc(Nc2ccc(OCCN3CCCCC3)cc2)nn1-c1cccc(n1)N1CCOCC1
Show InChI InChI=1S/C24H32N8O2/c25-23-28-24(29-32(23)22-6-4-5-21(27-22)31-14-16-33-17-15-31)26-19-7-9-20(10-8-19)34-18-13-30-11-2-1-3-12-30/h4-10H,1-3,11-18H2,(H3,25,26,28,29)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313026
PNG
(N-{2-[(4aR,6S,8aR)-2-amino-6-methyl-4,4a,5,6-tetra...)
Show SMILES CN(C)c1cccc(n1)-n1nc(Nc2ccc(OCCN3CCCCC3)cc2)nc1N
Show InChI InChI=1S/C22H30N8O/c1-28(2)19-7-6-8-20(25-19)30-21(23)26-22(27-30)24-17-9-11-18(12-10-17)31-16-15-29-13-4-3-5-14-29/h6-12H,3-5,13-16H2,1-2H3,(H3,23,24,26,27)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313153
PNG
(1-(7-methyl-2-chlorothieno[3,2-d] pyrimidin-4-yl)-...)
Show SMILES Cc1csc2c(nc(Cl)nc12)-n1nc(Nc2ccc(N3Cc4ccccc4C3)c(F)c2)nc1N
Show InChI InChI=1S/C23H18ClFN8S/c1-12-11-34-19-18(12)28-21(24)29-20(19)33-22(26)30-23(31-33)27-15-6-7-17(16(25)8-15)32-9-13-4-2-3-5-14(13)10-32/h2-8,11H,9-10H2,1H3,(H3,26,27,30,31)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM312993
PNG
(1-(4-isopropylphenyl)-N3-(4-(2-(piperidin-1-yl)eth...)
Show SMILES CC(C)c1ccc(cc1)-n1nc(Nc2ccc(OCCN3CCCCC3)cc2)nc1N
Show InChI InChI=1S/C24H32N6O/c1-18(2)19-6-10-21(11-7-19)30-23(25)27-24(28-30)26-20-8-12-22(13-9-20)31-17-16-29-14-4-3-5-15-29/h6-13,18H,3-5,14-17H2,1-2H3,(H3,25,26,27,28)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313141
PNG
(4-(5-amino-3-(4-(1-methylpiperidin-4-yl)phenylamin...)
Show SMILES CN1CCC(CC1)c1ccc(Nc2nc(N)n(n2)-c2ncnc3cc(O)c(O)cc23)cc1
Show InChI InChI=1S/C22H24N8O2/c1-29-8-6-14(7-9-29)13-2-4-15(5-3-13)26-22-27-21(23)30(28-22)20-16-10-18(31)19(32)11-17(16)24-12-25-20/h2-5,10-12,14,31-32H,6-9H2,1H3,(H3,23,26,27,28)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313064
PNG
(US10166216, Compound 43 | methyl 1-(2-(4-(5-amino-...)
Show SMILES COC(=O)C1CCCN1CCOc1ccc(Nc2nc(N)n(n2)-c2nc3ccccc3s2)cc1
Show InChI InChI=1S/C23H25N7O3S/c1-32-20(31)18-6-4-12-29(18)13-14-33-16-10-8-15(9-11-16)25-22-27-21(24)30(28-22)23-26-17-5-2-3-7-19(17)34-23/h2-3,5,7-11,18H,4,6,12-14H2,1H3,(H3,24,25,27,28)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313001
PNG
(N-{2-[(4aR,6S,8aR)-2-amino-6-methyl-4,4a,5,6-tetra...)
Show SMILES Nc1nc(Nc2ccc(OCCN3CCCC3)cc2)nn1-c1nc2ccccc2s1
Show InChI InChI=1S/C21H23N7OS/c22-19-25-20(26-28(19)21-24-17-5-1-2-6-18(17)30-21)23-15-7-9-16(10-8-15)29-14-13-27-11-3-4-12-27/h1-2,5-10H,3-4,11-14H2,(H3,22,23,25,26)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313110
PNG
(1-(benzo[d]thiazol-2-yl)-N5-(4-(4-(bicyclo[2.2.1]h...)
Show SMILES Nc1nc(Nc2ccc(cc2)N2CCN(CC2)C2CC3CCC2C3)n(n1)-c1nc2ccccc2s1
Show InChI InChI=1S/C26H30N8S/c27-24-30-25(34(31-24)26-29-21-3-1-2-4-23(21)35-26)28-19-7-9-20(10-8-19)32-11-13-33(14-12-32)22-16-17-5-6-18(22)15-17/h1-4,7-10,17-18,22H,5-6,11-16H2,(H3,27,28,30,31)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313156
PNG
(1-phenyl-N3-(4-(methylaminocarbonyl)-phenyl)-N5-me...)
Show SMILES CNC(=O)c1ccc(Nc2nc(NC)n(n2)-c2ccc(cc2)C(C)C)cc1
Show InChI InChI=1S/C20H24N6O/c1-13(2)14-7-11-17(12-8-14)26-20(22-4)24-19(25-26)23-16-9-5-15(6-10-16)18(27)21-3/h5-13H,1-4H3,(H,21,27)(H2,22,23,24,25)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM312998
PNG
(4-(5-amino-3-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyla...)
Show SMILES Nc1nc(Nc2ccc(OCCN3CCCC3)cc2)nn1-c1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C20H25N7O3S/c21-19-24-20(25-27(19)16-5-9-18(10-6-16)31(22,28)29)23-15-3-7-17(8-4-15)30-14-13-26-11-1-2-12-26/h3-10H,1-2,11-14H2,(H2,22,28,29)(H3,21,23,24,25)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313114
PNG
(N3-(4-methoxyphenyl)-1-(pyridin-2-yl)-1H-1,2,4-tri...)
Show SMILES COc1ccc(Nc2nc(N)n(n2)-c2ccccn2)cc1
Show InChI InChI=1S/C14H14N6O/c1-21-11-7-5-10(6-8-11)17-14-18-13(15)20(19-14)12-4-2-3-9-16-12/h2-9H,1H3,(H3,15,17,18,19)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313115
PNG
(US10166216, Compound 143 | ethyl 4-(5-amino-1-(2-c...)
Show SMILES CCOC(=O)c1ccc(Nc2nc(N)n(n2)-c2ccnc(Cl)c2)cc1
Show InChI InChI=1S/C16H15ClN6O2/c1-2-25-14(24)10-3-5-11(6-4-10)20-16-21-15(18)23(22-16)12-7-8-19-13(17)9-12/h3-9H,2H2,1H3,(H3,18,20,21,22)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313154
PNG
(1-(6,7-dimethoxyquinazolin-4-yl)-N3-(3-fluoro-4-(i...)
Show SMILES COc1cc2ncnc(-n3nc(Nc4ccc(N5Cc6ccccc6C5)c(F)c4)nc3N)c2cc1OC
Show InChI InChI=1S/C26H23FN8O2/c1-36-22-10-18-20(11-23(22)37-2)29-14-30-24(18)35-25(28)32-26(33-35)31-17-7-8-21(19(27)9-17)34-12-15-5-3-4-6-16(15)13-34/h3-11,14H,12-13H2,1-2H3,(H3,28,31,32,33)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313155
PNG
(1-(4-isopropylphenyl)-N3-(4-morpholinophenyl)-1H-1...)
Show SMILES CC(C)c1ccc(cc1)-n1nc(Nc2ccc(cc2)N2CCOCC2)nc1N
Show InChI InChI=1S/C21H26N6O/c1-15(2)16-3-7-19(8-4-16)27-20(22)24-21(25-27)23-17-5-9-18(10-6-17)26-11-13-28-14-12-26/h3-10,15H,11-14H2,1-2H3,(H3,22,23,24,25)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313013
PNG
(N-{2-[(4aR,6S,8aR)-2-amino-6-methyl-4,4a,5,6-tetra...)
Show SMILES CC1CCCN1CCOc1ccc(Nc2nc(N)n(n2)-c2nc3ccccc3n2C)cc1
Show InChI InChI=1S/C23H28N8O/c1-16-6-5-13-30(16)14-15-32-18-11-9-17(10-12-18)25-22-27-21(24)31(28-22)23-26-19-7-3-4-8-20(19)29(23)2/h3-4,7-12,16H,5-6,13-15H2,1-2H3,(H3,24,25,27,28)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313014
PNG
(N-{2-[(4aR,6S,8aR)-2-amino-6-methyl-4,4a,5,6-tetra...)
Show SMILES CC1CCCN1CCOc1ccc(Nc2nc(N)n(n2)-c2nc3ccccc3[nH]2)cc1
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313021
PNG
(N-{2-[(4aR,6S,8aR)-2-amino-6-methyl-4,4a,5,6-tetra...)
Show SMILES Nc1nc(Nc2ccc(OCCN3CCCC3)cc2)nn1-c1nc2ccccc2[nH]1
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313024
PNG
(N-{2-[(4aR,6S,8aR)-2-amino-6-methyl-4,4a,5,6-tetra...)
Show SMILES Nc1nc(Nc2ccc(OCCN3CCCC3)cc2)nn1-c1ccccc1F
Show InChI InChI=1S/C20H23FN6O/c21-17-5-1-2-6-18(17)27-19(22)24-20(25-27)23-15-7-9-16(10-8-15)28-14-13-26-11-3-4-12-26/h1-2,5-10H,3-4,11-14H2,(H3,22,23,24,25)
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313068
PNG
(1-(pyrimidin-2-yl)-N3-(4-(2-(pyrrolidin-1-yl)ethox...)
Show SMILES Nc1nc(Nc2ccc(OCCN3CCCC3)cc2)nn1-c1ncccn1
Show InChI InChI=1S/C18H22N8O/c19-16-23-17(24-26(16)18-20-8-3-9-21-18)22-14-4-6-15(7-5-14)27-13-12-25-10-1-2-11-25/h3-9H,1-2,10-13H2,(H3,19,22,23,24)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313102
PNG
(1-(7-(benzyloxy)-6-methoxyquinazolin-4-yl)-N3-(4-(...)
Show SMILES COc1cc2c(ncnc2cc1OCc1ccccc1)-n1nc(Nc2ccc(OCCN3CCCC3)cc2)nc1N
Show InChI InChI=1S/C30H32N8O3/c1-39-26-17-24-25(18-27(26)41-19-21-7-3-2-4-8-21)32-20-33-28(24)38-29(31)35-30(36-38)34-22-9-11-23(12-10-22)40-16-15-37-13-5-6-14-37/h2-4,7-12,17-18,20H,5-6,13-16,19H2,1H3,(H3,31,34,35,36)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313119
PNG
(1-(4-(5-amino-1-(2-fluorophenyl)-1H-1,2,4-triazol-...)
Show SMILES CC(=O)c1ccc(Nc2nc(N)n(n2)-c2ccccc2F)cc1
Show InChI InChI=1S/C16H14FN5O/c1-10(23)11-6-8-12(9-7-11)19-16-20-15(18)22(21-16)14-5-3-2-4-13(14)17/h2-9H,1H3,(H3,18,19,20,21)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313121
PNG
(1-(pyridin-2-yl)-N3-(3,4,5-trifluorophenyl)-1H-1,2...)
Show SMILES Nc1nc(Nc2cc(F)c(F)c(F)c2)nn1-c1ccccn1
Show InChI InChI=1S/C13H9F3N6/c14-8-5-7(6-9(15)11(8)16)19-13-20-12(17)22(21-13)10-3-1-2-4-18-10/h1-6H,(H3,17,19,20,21)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313005
PNG
(N-{2-[(4aR,6S,8aR)-2-amino-6-methyl-4,4a,5,6-tetra...)
Show SMILES Nc1nc(Nc2ccc(OCCN3CCCCC3)cc2)nn1-c1ccnc(c1)N1CCOCC1
Show InChI InChI=1S/C24H32N8O2/c25-23-28-24(29-32(23)20-8-9-26-22(18-20)31-13-15-33-16-14-31)27-19-4-6-21(7-5-19)34-17-12-30-10-2-1-3-11-30/h4-9,18H,1-3,10-17H2,(H3,25,27,28,29)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313008
PNG
(N-{2-[(4aR,6S,8aR)-2-amino-6-methyl-4,4a,5,6-tetra...)
Show SMILES Nc1nc(Nc2ccc(OCCN3CCCC3)cc2)nn1-c1ncccc1Cl
Show InChI InChI=1S/C19H22ClN7O/c20-16-4-3-9-22-17(16)27-18(21)24-19(25-27)23-14-5-7-15(8-6-14)28-13-12-26-10-1-2-11-26/h3-9H,1-2,10-13H2,(H3,21,23,24,25)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313018
PNG
(N-{2-[(4aR,6S,8aR)-2-amino-6-methyl-4,4a,5,6-tetra...)
Show SMILES Nc1nc(Nc2ccc(OCCN3CCCCC3)cc2)nn1-c1ccccc1F
Show InChI InChI=1S/C21H25FN6O/c22-18-6-2-3-7-19(18)28-20(23)25-21(26-28)24-16-8-10-17(11-9-16)29-15-14-27-12-4-1-5-13-27/h2-3,6-11H,1,4-5,12-15H2,(H3,23,24,25,26)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313022
PNG
(N-{2-[(4aR,6S,8aR)-2-amino-6-methyl-4,4a,5,6-tetra...)
Show SMILES Nc1nc(Nc2ccc(OCCN3CCCC3)cc2)nn1-c1ccc(Br)cn1
Show InChI InChI=1S/C19H22BrN7O/c20-14-3-8-17(22-13-14)27-18(21)24-19(25-27)23-15-4-6-16(7-5-15)28-12-11-26-9-1-2-10-26/h3-8,13H,1-2,9-12H2,(H3,21,23,24,25)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313118
PNG
((S)-4-(5-amino-1-(2-(2-(pyrrolidin-1-ylmethyl)pyrr...)
Show SMILES Nc1nc(Nc2ccc(cc2)C(O)=O)nn1-c1ccnc(c1)N1CCC[C@H]1CN1CCCC1
Show InChI InChI=1S/C23H28N8O2/c24-22-27-23(26-17-7-5-16(6-8-17)21(32)33)28-31(22)18-9-10-25-20(14-18)30-13-3-4-19(30)15-29-11-1-2-12-29/h5-10,14,19H,1-4,11-13,15H2,(H,32,33)(H3,24,26,27,28)/t19-/m0/s1
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313135
PNG
(1-(isoquinolin-1-yl)-N3-(4-(oxazol-5-yl)phenyl)-1H...)
Show SMILES Nc1nc(Nc2ccc(cc2)-c2cnco2)nn1-c1nccc2ccccc12
Show InChI InChI=1S/C20H15N7O/c21-19-25-20(24-15-7-5-14(6-8-15)17-11-22-12-28-17)26-27(19)18-16-4-2-1-3-13(16)9-10-23-18/h1-12H,(H3,21,24,25,26)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313012
PNG
(N-{2-[(4aR,6S,8aR)-2-amino-6-methyl-4,4a,5,6-tetra...)
Show SMILES CC1CCCN1CCOc1ccc(Nc2nc(N)n(n2)-c2nc3ccccc3s2)cc1
Show InChI InChI=1S/C22H25N7OS/c1-15-5-4-12-28(15)13-14-30-17-10-8-16(9-11-17)24-21-26-20(23)29(27-21)22-25-18-6-2-3-7-19(18)31-22/h2-3,6-11,15H,4-5,12-14H2,1H3,(H3,23,24,26,27)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313122
PNG
(3-(5-amino-1-(pyridin-2-yl)-1H-1,2,4-triazol-3-yla...)
Show SMILES Nc1nc(Nc2cccc(O)c2)nn1-c1ccccn1
Show InChI InChI=1S/C13H12N6O/c14-12-17-13(16-9-4-3-5-10(20)8-9)18-19(12)11-6-1-2-7-15-11/h1-8,20H,(H3,14,16,17,18)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313157
PNG
(1-phenyl-N3-(4-(ethyloxocarbonyl) phenyl)-N5-methy...)
Show SMILES CCOC(=O)c1ccc(Nc2nc(NC)n(n2)-c2ccc(cc2)C(C)C)cc1
Show InChI InChI=1S/C21H25N5O2/c1-5-28-19(27)16-6-10-17(11-7-16)23-20-24-21(22-4)26(25-20)18-12-8-15(9-13-18)14(2)3/h6-14H,5H2,1-4H3,(H2,22,23,24,25)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313166
PNG
(1-(isoquinolin-1-yl)-N5-(4-morpholinophenyl)-1H-1,...)
Show SMILES Nc1nc(Nc2ccc(cc2)N2CCOCC2)n(n1)-c1nccc2ccccc12
Show InChI InChI=1S/C21H21N7O/c22-20-25-21(24-16-5-7-17(8-6-16)27-11-13-29-14-12-27)28(26-20)19-18-4-2-1-3-15(18)9-10-23-19/h1-10H,11-14H2,(H3,22,24,25,26)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM312992
PNG
(1-phneyl-N3-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-1...)
Show SMILES Nc1nc(Nc2ccc(OCCN3CCCCC3)cc2)nn1-c1ccccc1
Show InChI InChI=1S/C21H26N6O/c22-20-24-21(25-27(20)18-7-3-1-4-8-18)23-17-9-11-19(12-10-17)28-16-15-26-13-5-2-6-14-26/h1,3-4,7-12H,2,5-6,13-16H2,(H3,22,23,24,25)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM312996
PNG
(N5-methyl-1-(pyridin-2-yl)-N3-(4-(2-(pyrrolidin-1-...)
Show SMILES CNc1nc(Nc2ccc(OCCN3CCCC3)cc2)nn1-c1ccccn1
Show InChI InChI=1S/C20H25N7O/c1-21-20-24-19(25-27(20)18-6-2-3-11-22-18)23-16-7-9-17(10-8-16)28-15-14-26-12-4-5-13-26/h2-3,6-11H,4-5,12-15H2,1H3,(H2,21,23,24,25)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313000
PNG
(1-(2-chloropyridin-4-yl)-N3-(4-(2-(piperidin-1-yl)...)
Show SMILES Nc1nc(Nc2ccc(OCCN3CCCCC3)cc2)nn1-c1ccnc(Cl)c1
Show InChI InChI=1S/C20H24ClN7O/c21-18-14-16(8-9-23-18)28-19(22)25-20(26-28)24-15-4-6-17(7-5-15)29-13-12-27-10-2-1-3-11-27/h4-9,14H,1-3,10-13H2,(H3,22,24,25,26)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313063
PNG
(2-(5-amino-3-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyla...)
Show SMILES Cc1cc(O)nc(n1)-n1nc(Nc2ccc(OCCN3CCCC3)cc2)nc1N
Show InChI InChI=1S/C19H24N8O2/c1-13-12-16(28)23-19(21-13)27-17(20)24-18(25-27)22-14-4-6-15(7-5-14)29-11-10-26-8-2-3-9-26/h4-7,12H,2-3,8-11H2,1H3,(H,21,23,28)(H3,20,22,24,25)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313116
PNG
(1-(4-(5-amino-1-(quinoxalin-2-yl)-1H-1,2,4-triazol...)
Show SMILES CC(=O)c1ccc(Nc2nc(N)n(n2)-c2cnc3ccccc3n2)cc1
Show InChI InChI=1S/C18H15N7O/c1-11(26)12-6-8-13(9-7-12)21-18-23-17(19)25(24-18)16-10-20-14-4-2-3-5-15(14)22-16/h2-10H,1H3,(H3,19,21,23,24)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313004
PNG
(N-{2-[(4aR,6S,8aR)-2-amino-6-methyl-4,4a,5,6-tetra...)
Show SMILES Cn1c(nc2ccccc12)-n1nc(Nc2ccc(OCCN3CCCC3)cc2)nc1N
Show InChI InChI=1S/C22H26N8O/c1-28-19-7-3-2-6-18(19)25-22(28)30-20(23)26-21(27-30)24-16-8-10-17(11-9-16)31-15-14-29-12-4-5-13-29/h2-3,6-11H,4-5,12-15H2,1H3,(H3,23,24,26,27)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313017
PNG
(N-{2-[(4aR,6S,8aR)-2-amino-6-methyl-4,4a,5,6-tetra...)
Show SMILES CC1CCCN1CCOc1ccc(Nc2nc(N)n(n2)-c2ccccc2F)cc1
Show InChI InChI=1S/C21H25FN6O/c1-15-5-4-12-27(15)13-14-29-17-10-8-16(9-11-17)24-21-25-20(23)28(26-21)19-7-3-2-6-18(19)22/h2-3,6-11,15H,4-5,12-14H2,1H3,(H3,23,24,25,26)
PDB

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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313123
PNG
(3-(4-(5-amino-1-(quinoxalin-2-yl)-1H-1,2,4-triazol...)
Show SMILES Nc1nc(Nc2ccc(CCC(=O)N3CCCC3)cc2)nn1-c1cnc2ccccc2n1
Show InChI InChI=1S/C23H24N8O/c24-22-28-23(29-31(22)20-15-25-18-5-1-2-6-19(18)27-20)26-17-10-7-16(8-11-17)9-12-21(32)30-13-3-4-14-30/h1-2,5-8,10-11,15H,3-4,9,12-14H2,(H3,24,26,28,29)
PDB

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UniChem
US Patent
n/an/a>2.00E+4n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313097
PNG
(2-(5-amino-3-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyla...)
Show SMILES Nc1nc(Nc2ccc(OCCN3CCCC3)cc2)nn1-c1nc(O)c2CCCCc2n1
Show InChI InChI=1S/C22H28N8O2/c23-20-27-21(28-30(20)22-25-18-6-2-1-5-17(18)19(31)26-22)24-15-7-9-16(10-8-15)32-14-13-29-11-3-4-12-29/h7-10H,1-6,11-14H2,(H,25,26,31)(H3,23,24,27,28)
PDB

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n/an/a>2.00E+4n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313107
PNG
(1-phenyl-N5-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-1...)
Show SMILES Nc1nc(Nc2ccc(OCCN3CCCCC3)cc2)n(n1)-c1ccccc1
Show InChI InChI=1S/C21H26N6O/c22-20-24-21(27(25-20)18-7-3-1-4-8-18)23-17-9-11-19(12-10-17)28-16-15-26-13-5-2-6-14-26/h1,3-4,7-12H,2,5-6,13-16H2,(H3,22,23,24,25)
PDB

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US Patent
n/an/a>2.00E+4n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%