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Patent code US10167280

Compile Data Set for Download or QSAR
Found 108 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Coagulation factor XI


(Homo sapiens (human))
BDBM313715
PNG
(5-({2-[4-(5-Chloro-2-cyanophenyl)-5-methoxy-2-oxop...)
Show SMILES CNC(=O)c1ccc(NC(=O)C(Cc2ccn(C)n2)n2cc(OC)c(cc2=O)-c2cc(Cl)ccc2C#N)cn1
Show InChI InChI=1S/C27H24ClN7O4/c1-30-26(37)22-7-6-19(14-31-22)32-27(38)23(11-18-8-9-34(2)33-18)35-15-24(39-3)21(12-25(35)36)20-10-17(28)5-4-16(20)13-29/h4-10,12,14-15,23H,11H2,1-3H3,(H,30,37)(H,32,38)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313704
PNG
(US10167280, Example 21 | US10167280, Example 44 | ...)
Show SMILES COc1cn(C(Cc2ccncc2)C(=O)Nc2ccc(nc2)C(N)=O)c(=O)cc1-c1cc(Cl)ccc1C#N
Show InChI InChI=1S/C27H21ClN6O4/c1-38-24-15-34(25(35)12-21(24)20-11-18(28)3-2-17(20)13-29)23(10-16-6-8-31-9-7-16)27(37)33-19-4-5-22(26(30)36)32-14-19/h2-9,11-12,14-15,23H,10H2,1H3,(H2,30,36)(H,33,37)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313714
PNG
(5-({2-[4-(5-Chloro-2-cyanophenyl)-5-methoxy-2-oxop...)
Show SMILES COc1cn(C(Cc2ccn(C)n2)C(=O)Nc2ccc(nc2)C(N)=O)c(=O)cc1-c1cc(Cl)ccc1C#N
Show InChI InChI=1S/C26H22ClN7O4/c1-33-8-7-17(32-33)10-22(26(37)31-18-5-6-21(25(29)36)30-13-18)34-14-23(38-2)20(11-24(34)35)19-9-16(27)4-3-15(19)12-28/h3-9,11,13-14,22H,10H2,1-2H3,(H2,29,36)(H,31,37)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313714
PNG
(5-({2-[4-(5-Chloro-2-cyanophenyl)-5-methoxy-2-oxop...)
Show SMILES COc1cn(C(Cc2ccn(C)n2)C(=O)Nc2ccc(nc2)C(N)=O)c(=O)cc1-c1cc(Cl)ccc1C#N
Show InChI InChI=1S/C26H22ClN7O4/c1-33-8-7-17(32-33)10-22(26(37)31-18-5-6-21(25(29)36)30-13-18)34-14-23(38-2)20(11-24(34)35)19-9-16(27)4-3-15(19)12-28/h3-9,11,13-14,22H,10H2,1-2H3,(H2,29,36)(H,31,37)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313723
PNG
(5-({2-[4-(5-Chloro-2-cyanophenyl)-5-methoxy-2-oxop...)
Show SMILES COc1cn(C(Cc2cc(C)on2)C(=O)Nc2ccc(nc2)C(N)=O)c(=O)cc1-c1cc(Cl)ccc1C#N
Show InChI InChI=1S/C26H21ClN6O5/c1-14-7-18(32-38-14)9-22(26(36)31-17-5-6-21(25(29)35)30-12-17)33-13-23(37-2)20(10-24(33)34)19-8-16(27)4-3-15(19)11-28/h3-8,10,12-13,22H,9H2,1-2H3,(H2,29,35)(H,31,36)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313715
PNG
(5-({2-[4-(5-Chloro-2-cyanophenyl)-5-methoxy-2-oxop...)
Show SMILES CNC(=O)c1ccc(NC(=O)C(Cc2ccn(C)n2)n2cc(OC)c(cc2=O)-c2cc(Cl)ccc2C#N)cn1
Show InChI InChI=1S/C27H24ClN7O4/c1-30-26(37)22-7-6-19(14-31-22)32-27(38)23(11-18-8-9-34(2)33-18)35-15-24(39-3)21(12-25(35)36)20-10-17(28)5-4-16(20)13-29/h4-10,12,14-15,23H,11H2,1-3H3,(H,30,37)(H,32,38)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313721
PNG
(5-({2-[4-(5-Chloro-2-cyanophenyl)-5-methoxy-2-oxop...)
Show SMILES CNC(=O)c1ccc(NC(=O)C(CCOC)n2cc(OC)c(cc2=O)-c2cc(Cl)ccc2C#N)cn1
Show InChI InChI=1S/C25H24ClN5O5/c1-28-24(33)20-7-6-17(13-29-20)30-25(34)21(8-9-35-2)31-14-22(36-3)19(11-23(31)32)18-10-16(26)5-4-15(18)12-27/h4-7,10-11,13-14,21H,8-9H2,1-3H3,(H,28,33)(H,30,34)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313719
PNG
(5-({2-[4-(5-Chloro-2-cyanophenyl)-5-methoxy-2-oxop...)
Show SMILES COCCC(C(=O)Nc1ccc(nc1)C(N)=O)n1cc(OC)c(cc1=O)-c1cc(Cl)ccc1C#N
Show InChI InChI=1S/C24H22ClN5O5/c1-34-8-7-20(24(33)29-16-5-6-19(23(27)32)28-12-16)30-13-21(35-2)18(10-22(30)31)17-9-15(25)4-3-14(17)11-26/h3-6,9-10,12-13,20H,7-8H2,1-2H3,(H2,27,32)(H,29,33)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313704
PNG
(US10167280, Example 21 | US10167280, Example 44 | ...)
Show SMILES COc1cn(C(Cc2ccncc2)C(=O)Nc2ccc(nc2)C(N)=O)c(=O)cc1-c1cc(Cl)ccc1C#N
Show InChI InChI=1S/C27H21ClN6O4/c1-38-24-15-34(25(35)12-21(24)20-11-18(28)3-2-17(20)13-29)23(10-16-6-8-31-9-7-16)27(37)33-19-4-5-22(26(30)36)32-14-19/h2-9,11-12,14-15,23H,10H2,1H3,(H2,30,36)(H,33,37)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313703
PNG
(US10167280, Example 8)
Show SMILES COc1cn(C(Cc2cccnc2)C(=O)Nc2ccc(nc2)C(N)=O)c(=O)cc1-c1cc(Cl)ccc1C#N
Show InChI InChI=1S/C27H21ClN6O4/c1-38-24-15-34(25(35)11-21(24)20-10-18(28)5-4-17(20)12-29)23(9-16-3-2-8-31-13-16)27(37)33-19-6-7-22(26(30)36)32-14-19/h2-8,10-11,13-15,23H,9H2,1H3,(H2,30,36)(H,33,37)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313712
PNG
(US10167280, Example 17 | US10167280, Example 22)
Show SMILES COc1cn(C(Cc2cnco2)C(=O)Nc2ccc(nc2)C(N)=O)c(=O)cc1-c1cc(Cl)ccc1C#N
Show InChI InChI=1S/C25H19ClN6O5/c1-36-22-12-32(23(33)8-19(22)18-6-15(26)3-2-14(18)9-27)21(7-17-11-29-13-37-17)25(35)31-16-4-5-20(24(28)34)30-10-16/h2-6,8,10-13,21H,7H2,1H3,(H2,28,34)(H,31,35)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313721
PNG
(5-({2-[4-(5-Chloro-2-cyanophenyl)-5-methoxy-2-oxop...)
Show SMILES CNC(=O)c1ccc(NC(=O)C(CCOC)n2cc(OC)c(cc2=O)-c2cc(Cl)ccc2C#N)cn1
Show InChI InChI=1S/C25H24ClN5O5/c1-28-24(33)20-7-6-17(13-29-20)30-25(34)21(8-9-35-2)31-14-22(36-3)19(11-23(31)32)18-10-16(26)5-4-15(18)12-27/h4-7,10-11,13-14,21H,8-9H2,1-3H3,(H,28,33)(H,30,34)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313719
PNG
(5-({2-[4-(5-Chloro-2-cyanophenyl)-5-methoxy-2-oxop...)
Show SMILES COCCC(C(=O)Nc1ccc(nc1)C(N)=O)n1cc(OC)c(cc1=O)-c1cc(Cl)ccc1C#N
Show InChI InChI=1S/C24H22ClN5O5/c1-34-8-7-20(24(33)29-16-5-6-19(23(27)32)28-12-16)30-13-21(35-2)18(10-22(30)31)17-9-15(25)4-3-14(17)11-26/h3-6,9-10,12-13,20H,7-8H2,1-2H3,(H2,27,32)(H,29,33)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313712
PNG
(US10167280, Example 17 | US10167280, Example 22)
Show SMILES COc1cn(C(Cc2cnco2)C(=O)Nc2ccc(nc2)C(N)=O)c(=O)cc1-c1cc(Cl)ccc1C#N
Show InChI InChI=1S/C25H19ClN6O5/c1-36-22-12-32(23(33)8-19(22)18-6-15(26)3-2-14(18)9-27)21(7-17-11-29-13-37-17)25(35)31-16-4-5-20(24(28)34)30-10-16/h2-6,8,10-13,21H,7H2,1H3,(H2,28,34)(H,31,35)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313721
PNG
(5-({2-[4-(5-Chloro-2-cyanophenyl)-5-methoxy-2-oxop...)
Show SMILES CNC(=O)c1ccc(NC(=O)C(CCOC)n2cc(OC)c(cc2=O)-c2cc(Cl)ccc2C#N)cn1
Show InChI InChI=1S/C25H24ClN5O5/c1-28-24(33)20-7-6-17(13-29-20)30-25(34)21(8-9-35-2)31-14-22(36-3)19(11-23(31)32)18-10-16(26)5-4-15(18)12-27/h4-7,10-11,13-14,21H,8-9H2,1-3H3,(H,28,33)(H,30,34)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313701
PNG
(US10167280, Example 23 | US10167280, Example 6)
Show SMILES COc1cn(C(Cc2ccccn2)C(=O)Nc2ccc(nc2)C(N)=O)c(=O)cc1-c1cc(Cl)ccc1C#N
Show InChI InChI=1S/C27H21ClN6O4/c1-38-24-15-34(25(35)12-21(24)20-10-17(28)6-5-16(20)13-29)23(11-18-4-2-3-9-31-18)27(37)33-19-7-8-22(26(30)36)32-14-19/h2-10,12,14-15,23H,11H2,1H3,(H2,30,36)(H,33,37)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313701
PNG
(US10167280, Example 23 | US10167280, Example 6)
Show SMILES COc1cn(C(Cc2ccccn2)C(=O)Nc2ccc(nc2)C(N)=O)c(=O)cc1-c1cc(Cl)ccc1C#N
Show InChI InChI=1S/C27H21ClN6O4/c1-38-24-15-34(25(35)12-21(24)20-10-17(28)6-5-16(20)13-29)23(11-18-4-2-3-9-31-18)27(37)33-19-7-8-22(26(30)36)32-14-19/h2-10,12,14-15,23H,11H2,1H3,(H2,30,36)(H,33,37)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313719
PNG
(5-({2-[4-(5-Chloro-2-cyanophenyl)-5-methoxy-2-oxop...)
Show SMILES COCCC(C(=O)Nc1ccc(nc1)C(N)=O)n1cc(OC)c(cc1=O)-c1cc(Cl)ccc1C#N
Show InChI InChI=1S/C24H22ClN5O5/c1-34-8-7-20(24(33)29-16-5-6-19(23(27)32)28-12-16)30-13-21(35-2)18(10-22(30)31)17-9-15(25)4-3-14(17)11-26/h3-6,9-10,12-13,20H,7-8H2,1-2H3,(H2,27,32)(H,29,33)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313704
PNG
(US10167280, Example 21 | US10167280, Example 44 | ...)
Show SMILES COc1cn(C(Cc2ccncc2)C(=O)Nc2ccc(nc2)C(N)=O)c(=O)cc1-c1cc(Cl)ccc1C#N
Show InChI InChI=1S/C27H21ClN6O4/c1-38-24-15-34(25(35)12-21(24)20-11-18(28)3-2-17(20)13-29)23(10-16-6-8-31-9-7-16)27(37)33-19-4-5-22(26(30)36)32-14-19/h2-9,11-12,14-15,23H,10H2,1H3,(H2,30,36)(H,33,37)
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n/an/a 8n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313721
PNG
(5-({2-[4-(5-Chloro-2-cyanophenyl)-5-methoxy-2-oxop...)
Show SMILES CNC(=O)c1ccc(NC(=O)C(CCOC)n2cc(OC)c(cc2=O)-c2cc(Cl)ccc2C#N)cn1
Show InChI InChI=1S/C25H24ClN5O5/c1-28-24(33)20-7-6-17(13-29-20)30-25(34)21(8-9-35-2)31-14-22(36-3)19(11-23(31)32)18-10-16(26)5-4-15(18)12-27/h4-7,10-11,13-14,21H,8-9H2,1-3H3,(H,28,33)(H,30,34)
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n/an/a 8n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313724
PNG
(5-({2-[4-(2-Cyano-5-methylphenyl)-5-methoxy-2-oxop...)
Show SMILES CNC(=O)c1ccc(NC(=O)C(Cc2ccn(C)n2)n2cc(OC)c(cc2=O)-c2cc(C)ccc2C#N)cn1
Show InChI InChI=1S/C28H27N7O4/c1-17-5-6-18(14-29)21(11-17)22-13-26(36)35(16-25(22)39-4)24(12-19-9-10-34(3)33-19)28(38)32-20-7-8-23(31-15-20)27(37)30-2/h5-11,13,15-16,24H,12H2,1-4H3,(H,30,37)(H,32,38)
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n/an/a 8.20n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313719
PNG
(5-({2-[4-(5-Chloro-2-cyanophenyl)-5-methoxy-2-oxop...)
Show SMILES COCCC(C(=O)Nc1ccc(nc1)C(N)=O)n1cc(OC)c(cc1=O)-c1cc(Cl)ccc1C#N
Show InChI InChI=1S/C24H22ClN5O5/c1-34-8-7-20(24(33)29-16-5-6-19(23(27)32)28-12-16)30-13-21(35-2)18(10-22(30)31)17-9-15(25)4-3-14(17)11-26/h3-6,9-10,12-13,20H,7-8H2,1-2H3,(H2,27,32)(H,29,33)
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n/an/a 8.60n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313723
PNG
(5-({2-[4-(5-Chloro-2-cyanophenyl)-5-methoxy-2-oxop...)
Show SMILES COc1cn(C(Cc2cc(C)on2)C(=O)Nc2ccc(nc2)C(N)=O)c(=O)cc1-c1cc(Cl)ccc1C#N
Show InChI InChI=1S/C26H21ClN6O5/c1-14-7-18(32-38-14)9-22(26(36)31-17-5-6-21(25(29)35)30-12-17)33-13-23(37-2)20(10-24(33)34)19-8-16(27)4-3-15(19)11-28/h3-8,10,12-13,22H,9H2,1-2H3,(H2,29,35)(H,31,36)
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n/an/a 8.60n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313704
PNG
(US10167280, Example 21 | US10167280, Example 44 | ...)
Show SMILES COc1cn(C(Cc2ccncc2)C(=O)Nc2ccc(nc2)C(N)=O)c(=O)cc1-c1cc(Cl)ccc1C#N
Show InChI InChI=1S/C27H21ClN6O4/c1-38-24-15-34(25(35)12-21(24)20-11-18(28)3-2-17(20)13-29)23(10-16-6-8-31-9-7-16)27(37)33-19-4-5-22(26(30)36)32-14-19/h2-9,11-12,14-15,23H,10H2,1H3,(H2,30,36)(H,33,37)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313724
PNG
(5-({2-[4-(2-Cyano-5-methylphenyl)-5-methoxy-2-oxop...)
Show SMILES CNC(=O)c1ccc(NC(=O)C(Cc2ccn(C)n2)n2cc(OC)c(cc2=O)-c2cc(C)ccc2C#N)cn1
Show InChI InChI=1S/C28H27N7O4/c1-17-5-6-18(14-29)21(11-17)22-13-26(36)35(16-25(22)39-4)24(12-19-9-10-34(3)33-19)28(38)32-20-7-8-23(31-15-20)27(37)30-2/h5-11,13,15-16,24H,12H2,1-4H3,(H,30,37)(H,32,38)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313703
PNG
(US10167280, Example 8)
Show SMILES COc1cn(C(Cc2cccnc2)C(=O)Nc2ccc(nc2)C(N)=O)c(=O)cc1-c1cc(Cl)ccc1C#N
Show InChI InChI=1S/C27H21ClN6O4/c1-38-24-15-34(25(35)11-21(24)20-10-18(28)5-4-17(20)12-29)23(9-16-3-2-8-31-13-16)27(37)33-19-6-7-22(26(30)36)32-14-19/h2-8,10-11,13-15,23H,9H2,1H3,(H2,30,36)(H,33,37)
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n/an/a 11n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313727
PNG
(5-({2-[4-(5-Chloro-2-cyanophenyl)-5-methoxy-2-oxop...)
Show SMILES CNC(=O)c1ccc(NC(=O)C(Cc2cnco2)n2cc(OC)c(cc2=O)-c2cc(Cl)ccc2C#N)cn1
Show InChI InChI=1S/C26H21ClN6O5/c1-29-25(35)21-6-5-17(11-31-21)32-26(36)22(8-18-12-30-14-38-18)33-13-23(37-2)20(9-24(33)34)19-7-16(27)4-3-15(19)10-28/h3-7,9,11-14,22H,8H2,1-2H3,(H,29,35)(H,32,36)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313726
PNG
(5-({2-[4-(5-Chloro-2-cyanophenyl)-5-methoxy-2-oxop...)
Show SMILES COc1cn(C(Cc2ccn(C)n2)C(=O)Nc2cnc(C(N)=O)c(F)c2)c(=O)cc1-c1cc(Cl)ccc1C#N
Show InChI InChI=1S/C26H21ClFN7O4/c1-34-6-5-16(33-34)9-21(26(38)32-17-8-20(28)24(25(30)37)31-12-17)35-13-22(39-2)19(10-23(35)36)18-7-15(27)4-3-14(18)11-29/h3-8,10,12-13,21H,9H2,1-2H3,(H2,30,37)(H,32,38)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313700
PNG
(US10167280, Example 5)
Show SMILES CNC(=O)c1ccc(NC(=O)C(C[C@@H]2CCCCO2)n2cc(Cl)c(cc2=O)-c2cc(Cl)ccc2C#N)cn1
Show InChI InChI=1S/C27H25Cl2N5O4/c1-31-26(36)23-8-7-18(14-32-23)33-27(37)24(11-19-4-2-3-9-38-19)34-15-22(29)21(12-25(34)35)20-10-17(28)6-5-16(20)13-30/h5-8,10,12,14-15,19,24H,2-4,9,11H2,1H3,(H,31,36)(H,33,37)/t19-,24?/m0/s1
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313727
PNG
(5-({2-[4-(5-Chloro-2-cyanophenyl)-5-methoxy-2-oxop...)
Show SMILES CNC(=O)c1ccc(NC(=O)C(Cc2cnco2)n2cc(OC)c(cc2=O)-c2cc(Cl)ccc2C#N)cn1
Show InChI InChI=1S/C26H21ClN6O5/c1-29-25(35)21-6-5-17(11-31-21)32-26(36)22(8-18-12-30-14-38-18)33-13-23(37-2)20(9-24(33)34)19-7-16(27)4-3-15(19)10-28/h3-7,9,11-14,22H,8H2,1-2H3,(H,29,35)(H,32,36)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313728
PNG
(5-({2-[4-(2-Cyano-5-methylphenyl)-5-methoxy-2-oxop...)
Show SMILES COCCC(C(=O)Nc1ccc(nc1)C(N)=O)n1cc(OC)c(cc1=O)-c1cc(C)ccc1C#N
Show InChI InChI=1S/C25H25N5O5/c1-15-4-5-16(12-26)18(10-15)19-11-23(31)30(14-22(19)35-3)21(8-9-34-2)25(33)29-17-6-7-20(24(27)32)28-13-17/h4-7,10-11,13-14,21H,8-9H2,1-3H3,(H2,27,32)(H,29,33)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313731
PNG
(5-({2-[4-(5-Chloro-2-cyanophenyl)-5-methoxy-2-oxop...)
Show SMILES COc1cn(C(Cc2ncco2)C(=O)Nc2ccc(nc2)C(N)=O)c(=O)cc1-c1cc(Cl)ccc1C#N
Show InChI InChI=1S/C25H19ClN6O5/c1-36-21-13-32(23(33)9-18(21)17-8-15(26)3-2-14(17)11-27)20(10-22-29-6-7-37-22)25(35)31-16-4-5-19(24(28)34)30-12-16/h2-9,12-13,20H,10H2,1H3,(H2,28,34)(H,31,35)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313732
PNG
(5-({2-[4-(5-Chloro-2-cyanophenyl)-5-methoxy-2-oxop...)
Show SMILES COc1cn(C(Cc2cnco2)C(=O)Nc2cnc(C(N)=O)c(F)c2)c(=O)cc1-c1cc(Cl)ccc1C#N
Show InChI InChI=1S/C25H18ClFN6O5/c1-37-21-11-33(22(34)7-18(21)17-4-14(26)3-2-13(17)8-28)20(6-16-10-30-12-38-16)25(36)32-15-5-19(27)23(24(29)35)31-9-15/h2-5,7,9-12,20H,6H2,1H3,(H2,29,35)(H,32,36)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313733
PNG
(5-({2-[4-(5-Chloro-2-cyanophenyl)-5-methoxy-2-oxop...)
Show SMILES CNC(=O)c1ccc(NC(=O)C(Cc2coc(C)n2)n2cc(OC)c(cc2=O)-c2cc(Cl)ccc2C#N)cn1
Show InChI InChI=1S/C27H23ClN6O5/c1-15-32-19(14-39-15)9-23(27(37)33-18-6-7-22(31-12-18)26(36)30-2)34-13-24(38-3)21(10-25(34)35)20-8-17(28)5-4-16(20)11-29/h4-8,10,12-14,23H,9H2,1-3H3,(H,30,36)(H,33,37)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313697
PNG
(US10167280, Example 2)
Show SMILES CCC(C(=O)Nc1ccc(nc1)C(=O)NC)n1cc(OC)c(cc1=O)-c1cc(Cl)ccc1C#N
Show InChI InChI=1S/C24H22ClN5O4/c1-4-20(24(33)29-16-7-8-19(28-12-16)23(32)27-2)30-13-21(34-3)18(10-22(30)31)17-9-15(25)6-5-14(17)11-26/h5-10,12-13,20H,4H2,1-3H3,(H,27,32)(H,29,33)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313699
PNG
(US10167280, Example 4)
Show SMILES NC(=O)c1ccc(NC(=O)C(C[C@@H]2CCCCO2)n2cc(Cl)c(cc2=O)-c2cc(Cl)ccc2C#N)cn1
Show InChI InChI=1S/C26H23Cl2N5O4/c27-16-5-4-15(12-29)19(9-16)20-11-24(34)33(14-21(20)28)23(10-18-3-1-2-8-37-18)26(36)32-17-6-7-22(25(30)35)31-13-17/h4-7,9,11,13-14,18,23H,1-3,8,10H2,(H2,30,35)(H,32,36)/t18-,23?/m0/s1
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313725
PNG
(5-({2-[4-(2-Cyano-5-methylphenyl)-5-methoxy-2-oxop...)
Show SMILES COc1cn(C(Cc2ccn(C)n2)C(=O)Nc2ccc(nc2)C(N)=O)c(=O)cc1-c1cc(C)ccc1C#N
Show InChI InChI=1S/C27H25N7O4/c1-16-4-5-17(13-28)20(10-16)21-12-25(35)34(15-24(21)38-3)23(11-18-8-9-33(2)32-18)27(37)31-19-6-7-22(26(29)36)30-14-19/h4-10,12,14-15,23H,11H2,1-3H3,(H2,29,36)(H,31,37)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313728
PNG
(5-({2-[4-(2-Cyano-5-methylphenyl)-5-methoxy-2-oxop...)
Show SMILES COCCC(C(=O)Nc1ccc(nc1)C(N)=O)n1cc(OC)c(cc1=O)-c1cc(C)ccc1C#N
Show InChI InChI=1S/C25H25N5O5/c1-15-4-5-16(12-26)18(10-15)19-11-23(31)30(14-22(19)35-3)21(8-9-34-2)25(33)29-17-6-7-20(24(27)32)28-13-17/h4-7,10-11,13-14,21H,8-9H2,1-3H3,(H2,27,32)(H,29,33)
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n/an/a 19n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313730
PNG
(5-({2-[4-(5-Chloro-2-cyanophenyl)-5-methoxy-2-oxop...)
Show SMILES COc1cn(C(Cc2cc(C)no2)C(=O)Nc2ccc(nc2)C(N)=O)c(=O)cc1-c1cc(Cl)ccc1C#N
Show InChI InChI=1S/C26H21ClN6O5/c1-14-7-18(38-32-14)9-22(26(36)31-17-5-6-21(25(29)35)30-12-17)33-13-23(37-2)20(10-24(33)34)19-8-16(27)4-3-15(19)11-28/h3-8,10,12-13,22H,9H2,1-2H3,(H2,29,35)(H,31,36)
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n/an/a 19n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313731
PNG
(5-({2-[4-(5-Chloro-2-cyanophenyl)-5-methoxy-2-oxop...)
Show SMILES COc1cn(C(Cc2ncco2)C(=O)Nc2ccc(nc2)C(N)=O)c(=O)cc1-c1cc(Cl)ccc1C#N
Show InChI InChI=1S/C25H19ClN6O5/c1-36-21-13-32(23(33)9-18(21)17-8-15(26)3-2-14(17)11-27)20(10-22-29-6-7-37-22)25(35)31-16-4-5-19(24(28)34)30-12-16/h2-9,12-13,20H,10H2,1H3,(H2,28,34)(H,31,35)
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n/an/a 19n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313697
PNG
(US10167280, Example 2)
Show SMILES CCC(C(=O)Nc1ccc(nc1)C(=O)NC)n1cc(OC)c(cc1=O)-c1cc(Cl)ccc1C#N
Show InChI InChI=1S/C24H22ClN5O4/c1-4-20(24(33)29-16-7-8-19(28-12-16)23(32)27-2)30-13-21(34-3)18(10-22(30)31)17-9-15(25)6-5-14(17)11-26/h5-10,12-13,20H,4H2,1-3H3,(H,27,32)(H,29,33)
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n/an/a 20n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313696
PNG
(US10167280, Example 1)
Show SMILES CCC(C(=O)Nc1ccc(nc1)C(N)=O)n1cc(OC)c(cc1=O)-c1cc(Cl)ccc1C#N
Show InChI InChI=1S/C23H20ClN5O4/c1-3-19(23(32)28-15-6-7-18(22(26)31)27-11-15)29-12-20(33-2)17(9-21(29)30)16-8-14(24)5-4-13(16)10-25/h4-9,11-12,19H,3H2,1-2H3,(H2,26,31)(H,28,32)
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n/an/a 20n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313701
PNG
(US10167280, Example 23 | US10167280, Example 6)
Show SMILES COc1cn(C(Cc2ccccn2)C(=O)Nc2ccc(nc2)C(N)=O)c(=O)cc1-c1cc(Cl)ccc1C#N
Show InChI InChI=1S/C27H21ClN6O4/c1-38-24-15-34(25(35)12-21(24)20-10-17(28)6-5-16(20)13-29)23(11-18-4-2-3-9-31-18)27(37)33-19-7-8-22(26(30)36)32-14-19/h2-10,12,14-15,23H,11H2,1H3,(H2,30,36)(H,33,37)
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n/an/a 20n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313725
PNG
(5-({2-[4-(2-Cyano-5-methylphenyl)-5-methoxy-2-oxop...)
Show SMILES COc1cn(C(Cc2ccn(C)n2)C(=O)Nc2ccc(nc2)C(N)=O)c(=O)cc1-c1cc(C)ccc1C#N
Show InChI InChI=1S/C27H25N7O4/c1-16-4-5-17(13-28)20(10-16)21-12-25(35)34(15-24(21)38-3)23(11-18-8-9-33(2)32-18)27(37)31-19-6-7-22(26(29)36)30-14-19/h4-10,12,14-15,23H,11H2,1-3H3,(H2,29,36)(H,31,37)
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n/an/a 20n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313696
PNG
(US10167280, Example 1)
Show SMILES CCC(C(=O)Nc1ccc(nc1)C(N)=O)n1cc(OC)c(cc1=O)-c1cc(Cl)ccc1C#N
Show InChI InChI=1S/C23H20ClN5O4/c1-3-19(23(32)28-15-6-7-18(22(26)31)27-11-15)29-12-20(33-2)17(9-21(29)30)16-8-14(24)5-4-13(16)10-25/h4-9,11-12,19H,3H2,1-2H3,(H2,26,31)(H,28,32)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313712
PNG
(US10167280, Example 17 | US10167280, Example 22)
Show SMILES COc1cn(C(Cc2cnco2)C(=O)Nc2ccc(nc2)C(N)=O)c(=O)cc1-c1cc(Cl)ccc1C#N
Show InChI InChI=1S/C25H19ClN6O5/c1-36-22-12-32(23(33)8-19(22)18-6-15(26)3-2-14(18)9-27)21(7-17-11-29-13-37-17)25(35)31-16-4-5-20(24(28)34)30-10-16/h2-6,8,10-13,21H,7H2,1H3,(H2,28,34)(H,31,35)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313701
PNG
(US10167280, Example 23 | US10167280, Example 6)
Show SMILES COc1cn(C(Cc2ccccn2)C(=O)Nc2ccc(nc2)C(N)=O)c(=O)cc1-c1cc(Cl)ccc1C#N
Show InChI InChI=1S/C27H21ClN6O4/c1-38-24-15-34(25(35)12-21(24)20-10-17(28)6-5-16(20)13-29)23(11-18-4-2-3-9-31-18)27(37)33-19-7-8-22(26(30)36)32-14-19/h2-10,12,14-15,23H,11H2,1H3,(H2,30,36)(H,33,37)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313710
PNG
(US10167280, Example 15)
Show SMILES CNC(=O)c1ccc(NC(=O)C(CCOC)n2cc(Cl)c(cc2=O)-c2cc(Cl)ccc2C#N)cn1
Show InChI InChI=1S/C24H21Cl2N5O4/c1-28-23(33)20-6-5-16(12-29-20)30-24(34)21(7-8-35-2)31-13-19(26)18(10-22(31)32)17-9-15(25)4-3-14(17)11-27/h3-6,9-10,12-13,21H,7-8H2,1-2H3,(H,28,33)(H,30,34)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313733
PNG
(5-({2-[4-(5-Chloro-2-cyanophenyl)-5-methoxy-2-oxop...)
Show SMILES CNC(=O)c1ccc(NC(=O)C(Cc2coc(C)n2)n2cc(OC)c(cc2=O)-c2cc(Cl)ccc2C#N)cn1
Show InChI InChI=1S/C27H23ClN6O5/c1-15-32-19(14-39-15)9-23(27(37)33-18-6-7-22(31-12-18)26(36)30-2)34-13-24(38-3)21(10-25(34)35)20-8-17(28)5-4-16(20)11-29/h4-8,10,12-14,23H,9H2,1-3H3,(H,30,36)(H,33,37)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313732
PNG
(5-({2-[4-(5-Chloro-2-cyanophenyl)-5-methoxy-2-oxop...)
Show SMILES COc1cn(C(Cc2cnco2)C(=O)Nc2cnc(C(N)=O)c(F)c2)c(=O)cc1-c1cc(Cl)ccc1C#N
Show InChI InChI=1S/C25H18ClFN6O5/c1-37-21-11-33(22(34)7-18(21)17-4-14(26)3-2-13(17)8-28)20(6-16-10-30-12-38-16)25(36)32-15-5-19(27)23(24(29)35)31-9-15/h2-5,7,9-12,20H,6H2,1H3,(H2,29,35)(H,32,36)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313735
PNG
(5-({2-[4-(5-Chloro-2-cyanophenyl)-5-methoxy-2-oxop...)
Show SMILES COc1cn(C(Cc2noc(C)n2)C(=O)Nc2ccc(nc2)C(N)=O)c(=O)cc1-c1cc(Cl)ccc1C#N
Show InChI InChI=1S/C25H20ClN7O5/c1-13-30-22(32-38-13)9-20(25(36)31-16-5-6-19(24(28)35)29-11-16)33-12-21(37-2)18(8-23(33)34)17-7-15(26)4-3-14(17)10-27/h3-8,11-12,20H,9H2,1-2H3,(H2,28,35)(H,31,36)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313735
PNG
(5-({2-[4-(5-Chloro-2-cyanophenyl)-5-methoxy-2-oxop...)
Show SMILES COc1cn(C(Cc2noc(C)n2)C(=O)Nc2ccc(nc2)C(N)=O)c(=O)cc1-c1cc(Cl)ccc1C#N
Show InChI InChI=1S/C25H20ClN7O5/c1-13-30-22(32-38-13)9-20(25(36)31-16-5-6-19(24(28)35)29-11-16)33-12-21(37-2)18(8-23(33)34)17-7-15(26)4-3-14(17)10-27/h3-8,11-12,20H,9H2,1-2H3,(H2,28,35)(H,31,36)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313712
PNG
(US10167280, Example 17 | US10167280, Example 22)
Show SMILES COc1cn(C(Cc2cnco2)C(=O)Nc2ccc(nc2)C(N)=O)c(=O)cc1-c1cc(Cl)ccc1C#N
Show InChI InChI=1S/C25H19ClN6O5/c1-36-22-12-32(23(33)8-19(22)18-6-15(26)3-2-14(18)9-27)21(7-17-11-29-13-37-17)25(35)31-16-4-5-20(24(28)34)30-10-16/h2-6,8,10-13,21H,7H2,1H3,(H2,28,34)(H,31,35)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313713
PNG
(5-({2-[4-(5-Chloro-2-cyanophenyl)-5-methoxy-2-oxop...)
Show SMILES CCC(C(=O)Nc1ccc(nc1)C(O)=O)n1cc(OC)c(cc1=O)-c1cc(Cl)ccc1C#N
Show InChI InChI=1S/C23H19ClN4O5/c1-3-19(22(30)27-15-6-7-18(23(31)32)26-11-15)28-12-20(33-2)17(9-21(28)29)16-8-14(24)5-4-13(16)10-25/h4-9,11-12,19H,3H2,1-2H3,(H,27,30)(H,31,32)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313734
PNG
(5-({2-[4-(5-Chloro-2-cyanophenyl)-5-methoxy-2-oxop...)
Show SMILES COc1cn(C(Cc2coc(C)n2)C(=O)Nc2ccc(nc2)C(N)=O)c(=O)cc1-c1cc(Cl)ccc1C#N
Show InChI InChI=1S/C26H21ClN6O5/c1-14-31-18(13-38-14)8-22(26(36)32-17-5-6-21(25(29)35)30-11-17)33-12-23(37-2)20(9-24(33)34)19-7-16(27)4-3-15(19)10-28/h3-7,9,11-13,22H,8H2,1-2H3,(H2,29,35)(H,32,36)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313698
PNG
(US10167280, Example 3)
Show SMILES COCCC(C(=O)Nc1ccc(nc1)C(N)=O)n1cc(Cl)c(cc1=O)-c1cc(Cl)ccc1C#N
Show InChI InChI=1S/C23H19Cl2N5O4/c1-34-7-6-20(23(33)29-15-4-5-19(22(27)32)28-11-15)30-12-18(25)17(9-21(30)31)16-8-14(24)3-2-13(16)10-26/h2-5,8-9,11-12,20H,6-7H2,1H3,(H2,27,32)(H,29,33)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313737
PNG
(5-({2-[4-(5-Chloro-2-cyanophenyl)-5-methoxy-2-oxop...)
Show SMILES CNC(=O)c1ccc(NC(=O)C(CC2=NOCC2)n2cc(OC)c(cc2=O)-c2cc(Cl)ccc2C#N)cn1
Show InChI InChI=1S/C26H23ClN6O5/c1-29-25(35)21-6-5-18(13-30-21)31-26(36)22(10-17-7-8-38-32-17)33-14-23(37-2)20(11-24(33)34)19-9-16(27)4-3-15(19)12-28/h3-6,9,11,13-14,22H,7-8,10H2,1-2H3,(H,29,35)(H,31,36)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313734
PNG
(5-({2-[4-(5-Chloro-2-cyanophenyl)-5-methoxy-2-oxop...)
Show SMILES COc1cn(C(Cc2coc(C)n2)C(=O)Nc2ccc(nc2)C(N)=O)c(=O)cc1-c1cc(Cl)ccc1C#N
Show InChI InChI=1S/C26H21ClN6O5/c1-14-31-18(13-38-14)8-22(26(36)32-17-5-6-21(25(29)35)30-11-17)33-12-23(37-2)20(9-24(33)34)19-7-16(27)4-3-15(19)10-28/h3-7,9,11-13,22H,8H2,1-2H3,(H2,29,35)(H,32,36)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313728
PNG
(5-({2-[4-(2-Cyano-5-methylphenyl)-5-methoxy-2-oxop...)
Show SMILES COCCC(C(=O)Nc1ccc(nc1)C(N)=O)n1cc(OC)c(cc1=O)-c1cc(C)ccc1C#N
Show InChI InChI=1S/C25H25N5O5/c1-15-4-5-16(12-26)18(10-15)19-11-23(31)30(14-22(19)35-3)21(8-9-34-2)25(33)29-17-6-7-20(24(27)32)28-13-17/h4-7,10-11,13-14,21H,8-9H2,1-3H3,(H2,27,32)(H,29,33)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313711
PNG
(US10167280, Example 16)
Show SMILES NC(=O)c1ccc(NC(=O)C(Cc2cnco2)n2cc(Cl)c(cc2=O)-c2cc(Cl)ccc2C#N)cn1
Show InChI InChI=1S/C24H16Cl2N6O4/c25-14-2-1-13(8-27)17(5-14)18-7-22(33)32(11-19(18)26)21(6-16-10-29-12-36-16)24(35)31-15-3-4-20(23(28)34)30-9-15/h1-5,7,9-12,21H,6H2,(H2,28,34)(H,31,35)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313728
PNG
(5-({2-[4-(2-Cyano-5-methylphenyl)-5-methoxy-2-oxop...)
Show SMILES COCCC(C(=O)Nc1ccc(nc1)C(N)=O)n1cc(OC)c(cc1=O)-c1cc(C)ccc1C#N
Show InChI InChI=1S/C25H25N5O5/c1-15-4-5-16(12-26)18(10-15)19-11-23(31)30(14-22(19)35-3)21(8-9-34-2)25(33)29-17-6-7-20(24(27)32)28-13-17/h4-7,10-11,13-14,21H,8-9H2,1-3H3,(H2,27,32)(H,29,33)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313736
PNG
(5-{[2-{4-[5-Chloro-2-(difluoromethyl)phenyl]-5-met...)
Show SMILES COc1cn(C(Cc2ccccn2)C(=O)Nc2ccc(nc2)C(N)=O)c(=O)cc1-c1cc(Cl)ccc1C(F)F
Show InChI InChI=1S/C27H22ClF2N5O4/c1-39-23-14-35(24(36)12-20(23)19-10-15(28)5-7-18(19)25(29)30)22(11-16-4-2-3-9-32-16)27(38)34-17-6-8-21(26(31)37)33-13-17/h2-10,12-14,22,25H,11H2,1H3,(H2,31,37)(H,34,38)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313706
PNG
(US10167280, Example 11)
Show SMILES COc1cn(C(Cc2cocn2)C(=O)Nc2ccc(nc2)C(N)=O)c(=O)cc1-c1cc(Cl)ccc1C#N
Show InChI InChI=1S/C25H19ClN6O5/c1-36-22-11-32(23(33)8-19(22)18-6-15(26)3-2-14(18)9-27)21(7-17-12-37-13-30-17)25(35)31-16-4-5-20(24(28)34)29-10-16/h2-6,8,10-13,21H,7H2,1H3,(H2,28,34)(H,31,35)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313737
PNG
(5-({2-[4-(5-Chloro-2-cyanophenyl)-5-methoxy-2-oxop...)
Show SMILES CNC(=O)c1ccc(NC(=O)C(CC2=NOCC2)n2cc(OC)c(cc2=O)-c2cc(Cl)ccc2C#N)cn1
Show InChI InChI=1S/C26H23ClN6O5/c1-29-25(35)21-6-5-18(13-30-21)31-26(36)22(10-17-7-8-38-32-17)33-14-23(37-2)20(11-24(33)34)19-9-16(27)4-3-15(19)12-28/h3-6,9,11,13-14,22H,7-8,10H2,1-2H3,(H,29,35)(H,31,36)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313706
PNG
(US10167280, Example 11)
Show SMILES COc1cn(C(Cc2cocn2)C(=O)Nc2ccc(nc2)C(N)=O)c(=O)cc1-c1cc(Cl)ccc1C#N
Show InChI InChI=1S/C25H19ClN6O5/c1-36-22-11-32(23(33)8-19(22)18-6-15(26)3-2-14(18)9-27)21(7-17-12-37-13-30-17)25(35)31-16-4-5-20(24(28)34)29-10-16/h2-6,8,10-13,21H,7H2,1H3,(H2,28,34)(H,31,35)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313710
PNG
(US10167280, Example 15)
Show SMILES CNC(=O)c1ccc(NC(=O)C(CCOC)n2cc(Cl)c(cc2=O)-c2cc(Cl)ccc2C#N)cn1
Show InChI InChI=1S/C24H21Cl2N5O4/c1-28-23(33)20-6-5-16(12-29-20)30-24(34)21(7-8-35-2)31-13-19(26)18(10-22(31)32)17-9-15(25)4-3-14(17)11-27/h3-6,9-10,12-13,21H,7-8H2,1-2H3,(H,28,33)(H,30,34)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313738
PNG
(5-({2-[4-(5-Chloro-2-cyanophenyl)-5-methyl-2-oxopy...)
Show SMILES CNC(=O)c1ccc(NC(=O)C(Cc2ccn(C)n2)n2cc(C)c(cc2=O)-c2cc(Cl)ccc2C#N)cn1
Show InChI InChI=1S/C27H24ClN7O3/c1-16-15-35(25(36)12-21(16)22-10-18(28)5-4-17(22)13-29)24(11-19-8-9-34(3)33-19)27(38)32-20-6-7-23(31-14-20)26(37)30-2/h4-10,12,14-15,24H,11H2,1-3H3,(H,30,37)(H,32,38)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313726
PNG
(5-({2-[4-(5-Chloro-2-cyanophenyl)-5-methoxy-2-oxop...)
Show SMILES COc1cn(C(Cc2ccn(C)n2)C(=O)Nc2cnc(C(N)=O)c(F)c2)c(=O)cc1-c1cc(Cl)ccc1C#N
Show InChI InChI=1S/C26H21ClFN7O4/c1-34-6-5-16(33-34)9-21(26(38)32-17-8-20(28)24(25(30)37)31-12-17)35-13-22(39-2)19(10-23(35)36)18-7-15(27)4-3-14(18)11-29/h3-8,10,12-13,21H,9H2,1-2H3,(H2,30,37)(H,32,38)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313736
PNG
(5-{[2-{4-[5-Chloro-2-(difluoromethyl)phenyl]-5-met...)
Show SMILES COc1cn(C(Cc2ccccn2)C(=O)Nc2ccc(nc2)C(N)=O)c(=O)cc1-c1cc(Cl)ccc1C(F)F
Show InChI InChI=1S/C27H22ClF2N5O4/c1-39-23-14-35(24(36)12-20(23)19-10-15(28)5-7-18(19)25(29)30)22(11-16-4-2-3-9-32-16)27(38)34-17-6-8-21(26(31)37)33-13-17/h2-10,12-14,22,25H,11H2,1H3,(H2,31,37)(H,34,38)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313738
PNG
(5-({2-[4-(5-Chloro-2-cyanophenyl)-5-methyl-2-oxopy...)
Show SMILES CNC(=O)c1ccc(NC(=O)C(Cc2ccn(C)n2)n2cc(C)c(cc2=O)-c2cc(Cl)ccc2C#N)cn1
Show InChI InChI=1S/C27H24ClN7O3/c1-16-15-35(25(36)12-21(16)22-10-18(28)5-4-17(22)13-29)24(11-19-8-9-34(3)33-19)27(38)32-20-6-7-23(31-14-20)26(37)30-2/h4-10,12,14-15,24H,11H2,1-3H3,(H,30,37)(H,32,38)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313746
PNG
(5-({2-[4-(5-Chloro-2-cyanophenyl)-5-cyclopropyl-2-...)
Show SMILES CNC(=O)c1ccc(NC(=O)C(Cc2ccn(C)n2)n2cc(C3CC3)c(cc2=O)-c2cc(Cl)ccc2C#N)cn1
Show InChI InChI=1S/C29H26ClN7O3/c1-32-28(39)25-8-7-21(15-33-25)34-29(40)26(12-20-9-10-36(2)35-20)37-16-24(17-3-4-17)23(13-27(37)38)22-11-19(30)6-5-18(22)14-31/h5-11,13,15-17,26H,3-4,12H2,1-2H3,(H,32,39)(H,34,40)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313711
PNG
(US10167280, Example 16)
Show SMILES NC(=O)c1ccc(NC(=O)C(Cc2cnco2)n2cc(Cl)c(cc2=O)-c2cc(Cl)ccc2C#N)cn1
Show InChI InChI=1S/C24H16Cl2N6O4/c25-14-2-1-13(8-27)17(5-14)18-7-22(33)32(11-19(18)26)21(6-16-10-29-12-36-16)24(35)31-15-3-4-20(23(28)34)30-9-15/h1-5,7,9-12,21H,6H2,(H2,28,34)(H,31,35)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313730
PNG
(5-({2-[4-(5-Chloro-2-cyanophenyl)-5-methoxy-2-oxop...)
Show SMILES COc1cn(C(Cc2cc(C)no2)C(=O)Nc2ccc(nc2)C(N)=O)c(=O)cc1-c1cc(Cl)ccc1C#N
Show InChI InChI=1S/C26H21ClN6O5/c1-14-7-18(38-32-14)9-22(26(36)31-17-5-6-21(25(29)35)30-12-17)33-13-23(37-2)20(10-24(33)34)19-8-16(27)4-3-15(19)11-28/h3-8,10,12-13,22H,9H2,1-2H3,(H2,29,35)(H,31,36)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313704
PNG
(US10167280, Example 21 | US10167280, Example 44 | ...)
Show SMILES COc1cn(C(Cc2ccncc2)C(=O)Nc2ccc(nc2)C(N)=O)c(=O)cc1-c1cc(Cl)ccc1C#N
Show InChI InChI=1S/C27H21ClN6O4/c1-38-24-15-34(25(35)12-21(24)20-11-18(28)3-2-17(20)13-29)23(10-16-6-8-31-9-7-16)27(37)33-19-4-5-22(26(30)36)32-14-19/h2-9,11-12,14-15,23H,10H2,1H3,(H2,30,36)(H,33,37)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313698
PNG
(US10167280, Example 3)
Show SMILES COCCC(C(=O)Nc1ccc(nc1)C(N)=O)n1cc(Cl)c(cc1=O)-c1cc(Cl)ccc1C#N
Show InChI InChI=1S/C23H19Cl2N5O4/c1-34-7-6-20(23(33)29-15-4-5-19(22(27)32)28-11-15)30-12-18(25)17(9-21(30)31)16-8-14(24)3-2-13(16)10-26/h2-5,8-9,11-12,20H,6-7H2,1H3,(H2,27,32)(H,29,33)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313713
PNG
(5-({2-[4-(5-Chloro-2-cyanophenyl)-5-methoxy-2-oxop...)
Show SMILES CCC(C(=O)Nc1ccc(nc1)C(O)=O)n1cc(OC)c(cc1=O)-c1cc(Cl)ccc1C#N
Show InChI InChI=1S/C23H19ClN4O5/c1-3-19(22(30)27-15-6-7-18(23(31)32)26-11-15)28-12-20(33-2)17(9-21(28)29)16-8-14(24)5-4-13(16)10-25/h4-9,11-12,19H,3H2,1-2H3,(H,27,30)(H,31,32)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313741
PNG
(5-({2-[4-(5-Chloro-2-cyano-4-fluorophenyl)-5-metho...)
Show SMILES CNC(=O)c1ccc(NC(=O)C(CCOC)n2cc(OC)c(cc2=O)-c2cc(Cl)c(F)cc2C#N)cn1
Show InChI InChI=1S/C25H23ClFN5O5/c1-29-24(34)20-5-4-15(12-30-20)31-25(35)21(6-7-36-2)32-13-22(37-3)17(10-23(32)33)16-9-18(26)19(27)8-14(16)11-28/h4-5,8-10,12-13,21H,6-7H2,1-3H3,(H,29,34)(H,31,35)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313743
PNG
(5-({2-[4-(2-Cyano-5-fluorophenyl)-5-methoxy-2-oxop...)
Show SMILES COc1cn(C(Cc2ccn(C)n2)C(=O)Nc2ccc(nc2)C(N)=O)c(=O)cc1-c1cc(F)ccc1C#N
Show InChI InChI=1S/C26H22FN7O4/c1-33-8-7-17(32-33)10-22(26(37)31-18-5-6-21(25(29)36)30-13-18)34-14-23(38-2)20(11-24(34)35)19-9-16(27)4-3-15(19)12-28/h3-9,11,13-14,22H,10H2,1-2H3,(H2,29,36)(H,31,37)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313740
PNG
(5-[(2-{4-[2-Cyano-5-(methylamino)phenyl]-5-methoxy...)
Show SMILES CNC(=O)c1ccc(NC(=O)C(CCOC)n2cc(OC)c(cc2=O)-c2cc(NC)ccc2C#N)cn1
Show InChI InChI=1S/C26H28N6O5/c1-28-17-6-5-16(13-27)19(11-17)20-12-24(33)32(15-23(20)37-4)22(9-10-36-3)26(35)31-18-7-8-21(30-14-18)25(34)29-2/h5-8,11-12,14-15,22,28H,9-10H2,1-4H3,(H,29,34)(H,31,35)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313700
PNG
(US10167280, Example 5)
Show SMILES CNC(=O)c1ccc(NC(=O)C(C[C@@H]2CCCCO2)n2cc(Cl)c(cc2=O)-c2cc(Cl)ccc2C#N)cn1
Show InChI InChI=1S/C27H25Cl2N5O4/c1-31-26(36)23-8-7-18(14-32-23)33-27(37)24(11-19-4-2-3-9-38-19)34-15-22(29)21(12-25(34)35)20-10-17(28)6-5-16(20)13-30/h5-8,10,12,14-15,19,24H,2-4,9,11H2,1H3,(H,31,36)(H,33,37)/t19-,24?/m0/s1
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313744
PNG
(5-({2-[4-(2-Cyano-5-fluorophenyl)-5-methoxy-2-oxop...)
Show SMILES CNC(=O)c1ccc(NC(=O)C(Cc2ccn(C)n2)n2cc(OC)c(cc2=O)-c2cc(F)ccc2C#N)cn1
Show InChI InChI=1S/C27H24FN7O4/c1-30-26(37)22-7-6-19(14-31-22)32-27(38)23(11-18-8-9-34(2)33-18)35-15-24(39-3)21(12-25(35)36)20-10-17(28)5-4-16(20)13-29/h4-10,12,14-15,23H,11H2,1-3H3,(H,30,37)(H,32,38)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313699
PNG
(US10167280, Example 4)
Show SMILES NC(=O)c1ccc(NC(=O)C(C[C@@H]2CCCCO2)n2cc(Cl)c(cc2=O)-c2cc(Cl)ccc2C#N)cn1
Show InChI InChI=1S/C26H23Cl2N5O4/c27-16-5-4-15(12-29)19(9-16)20-11-24(34)33(14-21(20)28)23(10-18-3-1-2-8-37-18)26(36)32-17-6-7-22(25(30)35)31-13-17/h4-7,9,11,13-14,18,23H,1-3,8,10H2,(H2,30,35)(H,32,36)/t18-,23?/m0/s1
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313743
PNG
(5-({2-[4-(2-Cyano-5-fluorophenyl)-5-methoxy-2-oxop...)
Show SMILES COc1cn(C(Cc2ccn(C)n2)C(=O)Nc2ccc(nc2)C(N)=O)c(=O)cc1-c1cc(F)ccc1C#N
Show InChI InChI=1S/C26H22FN7O4/c1-33-8-7-17(32-33)10-22(26(37)31-18-5-6-21(25(29)36)30-13-18)34-14-23(38-2)20(11-24(34)35)19-9-16(27)4-3-15(19)12-28/h3-9,11,13-14,22H,10H2,1-2H3,(H2,29,36)(H,31,37)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313741
PNG
(5-({2-[4-(5-Chloro-2-cyano-4-fluorophenyl)-5-metho...)
Show SMILES CNC(=O)c1ccc(NC(=O)C(CCOC)n2cc(OC)c(cc2=O)-c2cc(Cl)c(F)cc2C#N)cn1
Show InChI InChI=1S/C25H23ClFN5O5/c1-29-24(34)20-5-4-15(12-30-20)31-25(35)21(6-7-36-2)32-13-22(37-3)17(10-23(32)33)16-9-18(26)19(27)8-14(16)11-28/h4-5,8-10,12-13,21H,6-7H2,1-3H3,(H,29,34)(H,31,35)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313709
PNG
(US10167280, Example 14)
Show SMILES COc1cn(C(Cc2cc(C)no2)C(=O)Nc2ccc(nc2)C(N)=O)c(=O)cc1-c1cc(Cl)ccc1F
Show InChI InChI=1S/C25H21ClFN5O5/c1-13-7-16(37-31-13)9-21(25(35)30-15-4-6-20(24(28)34)29-11-15)32-12-22(36-2)18(10-23(32)33)17-8-14(26)3-5-19(17)27/h3-8,10-12,21H,9H2,1-2H3,(H2,28,34)(H,30,35)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313702
PNG
(US10167280, Example 7)
Show SMILES NC(=O)c1ccc(NC(=O)C(Cc2ccccn2)n2cc(OC(F)F)c(cc2=O)-c2cc(Cl)ccc2C#N)cn1
Show InChI InChI=1S/C27H19ClF2N6O4/c28-16-5-4-15(12-31)19(9-16)20-11-24(37)36(14-23(20)40-27(29)30)22(10-17-3-1-2-8-33-17)26(39)35-18-6-7-21(25(32)38)34-13-18/h1-9,11,13-14,22,27H,10H2,(H2,32,38)(H,35,39)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313744
PNG
(5-({2-[4-(2-Cyano-5-fluorophenyl)-5-methoxy-2-oxop...)
Show SMILES CNC(=O)c1ccc(NC(=O)C(Cc2ccn(C)n2)n2cc(OC)c(cc2=O)-c2cc(F)ccc2C#N)cn1
Show InChI InChI=1S/C27H24FN7O4/c1-30-26(37)22-7-6-19(14-31-22)32-27(38)23(11-18-8-9-34(2)33-18)35-15-24(39-3)21(12-25(35)36)20-10-17(28)5-4-16(20)13-29/h4-10,12,14-15,23H,11H2,1-3H3,(H,30,37)(H,32,38)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313742
PNG
(5-({2-[4-(5-Chloro-2-cyano-4-fluorophenyl)-5-metho...)
Show SMILES COCCC(C(=O)Nc1ccc(nc1)C(N)=O)n1cc(OC)c(cc1=O)-c1cc(Cl)c(F)cc1C#N
Show InChI InChI=1S/C24H21ClFN5O5/c1-35-6-5-20(24(34)30-14-3-4-19(23(28)33)29-11-14)31-12-21(36-2)16(9-22(31)32)15-8-17(25)18(26)7-13(15)10-27/h3-4,7-9,11-12,20H,5-6H2,1-2H3,(H2,28,33)(H,30,34)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313745
PNG
(5-({2-[4-(5-Chloro-2-cyano-3-fluorophenyl)-5-metho...)
Show SMILES COCCC(C(=O)Nc1ccc(nc1)C(N)=O)n1cc(OC)c(cc1=O)-c1cc(Cl)cc(F)c1C#N
Show InChI InChI=1S/C24H21ClFN5O5/c1-35-6-5-20(24(34)30-14-3-4-19(23(28)33)29-11-14)31-12-21(36-2)16(9-22(31)32)15-7-13(25)8-18(26)17(15)10-27/h3-4,7-9,11-12,20H,5-6H2,1-2H3,(H2,28,33)(H,30,34)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313746
PNG
(5-({2-[4-(5-Chloro-2-cyanophenyl)-5-cyclopropyl-2-...)
Show SMILES CNC(=O)c1ccc(NC(=O)C(Cc2ccn(C)n2)n2cc(C3CC3)c(cc2=O)-c2cc(Cl)ccc2C#N)cn1
Show InChI InChI=1S/C29H26ClN7O3/c1-32-28(39)25-8-7-21(15-33-25)34-29(40)26(12-20-9-10-36(2)35-20)37-16-24(17-3-4-17)23(13-27(37)38)22-11-19(30)6-5-18(22)14-31/h5-11,13,15-17,26H,3-4,12H2,1-2H3,(H,32,39)(H,34,40)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313749
PNG
(5-{[2-{4-[5-Chloro-2-(trifluoromethyl)phenyl]-5-me...)
Show SMILES COc1cn(C(Cc2cc(C)no2)C(=O)Nc2ccc(nc2)C(N)=O)c(=O)cc1-c1cc(Cl)ccc1C(F)(F)F
Show InChI InChI=1S/C26H21ClF3N5O5/c1-13-7-16(40-34-13)9-21(25(38)33-15-4-6-20(24(31)37)32-11-15)35-12-22(39-2)18(10-23(35)36)17-8-14(27)3-5-19(17)26(28,29)30/h3-8,10-12,21H,9H2,1-2H3,(H2,31,37)(H,33,38)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313705
PNG
(US10167280, Example 10)
Show SMILES NC(=O)c1ccc(NC(=O)C(Cc2cocn2)n2cc(Cl)c(cc2=O)-c2cc(Cl)ccc2C#N)cn1
Show InChI InChI=1S/C24H16Cl2N6O4/c25-14-2-1-13(8-27)17(5-14)18-7-22(33)32(10-19(18)26)21(6-16-11-36-12-30-16)24(35)31-15-3-4-20(23(28)34)29-9-15/h1-5,7,9-12,21H,6H2,(H2,28,34)(H,31,35)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313707
PNG
(US10167280, Example 12)
Show SMILES NC(=O)c1ccc(NC(=O)C(Cc2cnco2)n2cc(OC(F)F)c(cc2=O)-c2cc(Cl)ccc2C#N)cn1
Show InChI InChI=1S/C25H17ClF2N6O5/c26-14-2-1-13(8-29)17(5-14)18-7-22(35)34(11-21(18)39-25(27)28)20(6-16-10-31-12-38-16)24(37)33-15-3-4-19(23(30)36)32-9-15/h1-5,7,9-12,20,25H,6H2,(H2,30,36)(H,33,37)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313708
PNG
(US10167280, Example 13)
Show SMILES COc1cn(C(Cc2ccccn2)C(=O)Nc2ccc(nc2)C(N)=O)c(=O)cc1-c1cc(Cl)ccc1F
Show InChI InChI=1S/C26H21ClFN5O4/c1-37-23-14-33(24(34)12-19(23)18-10-15(27)5-7-20(18)28)22(11-16-4-2-3-9-30-16)26(36)32-17-6-8-21(25(29)35)31-13-17/h2-10,12-14,22H,11H2,1H3,(H2,29,35)(H,32,36)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313742
PNG
(5-({2-[4-(5-Chloro-2-cyano-4-fluorophenyl)-5-metho...)
Show SMILES COCCC(C(=O)Nc1ccc(nc1)C(N)=O)n1cc(OC)c(cc1=O)-c1cc(Cl)c(F)cc1C#N
Show InChI InChI=1S/C24H21ClFN5O5/c1-35-6-5-20(24(34)30-14-3-4-19(23(28)33)29-11-14)31-12-21(36-2)16(9-22(31)32)15-8-17(25)18(26)7-13(15)10-27/h3-4,7-9,11-12,20H,5-6H2,1-2H3,(H2,28,33)(H,30,34)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313708
PNG
(US10167280, Example 13)
Show SMILES COc1cn(C(Cc2ccccn2)C(=O)Nc2ccc(nc2)C(N)=O)c(=O)cc1-c1cc(Cl)ccc1F
Show InChI InChI=1S/C26H21ClFN5O4/c1-37-23-14-33(24(34)12-19(23)18-10-15(27)5-7-20(18)28)22(11-16-4-2-3-9-30-16)26(36)32-17-6-8-21(25(29)35)31-13-17/h2-10,12-14,22H,11H2,1H3,(H2,29,35)(H,32,36)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313747
PNG
(5-({2-[4-(5-Chloro-2-fluorophenyl)-5-methoxy-2-oxo...)
Show SMILES COc1cn(C(Cc2ncco2)C(=O)Nc2ccc(nc2)C(N)=O)c(=O)cc1-c1cc(Cl)ccc1F
Show InChI InChI=1S/C24H19ClFN5O5/c1-35-20-12-31(22(32)9-16(20)15-8-13(25)2-4-17(15)26)19(10-21-28-6-7-36-21)24(34)30-14-3-5-18(23(27)33)29-11-14/h2-9,11-12,19H,10H2,1H3,(H2,27,33)(H,30,34)
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n/an/a 300n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313747
PNG
(5-({2-[4-(5-Chloro-2-fluorophenyl)-5-methoxy-2-oxo...)
Show SMILES COc1cn(C(Cc2ncco2)C(=O)Nc2ccc(nc2)C(N)=O)c(=O)cc1-c1cc(Cl)ccc1F
Show InChI InChI=1S/C24H19ClFN5O5/c1-35-20-12-31(22(32)9-16(20)15-8-13(25)2-4-17(15)26)19(10-21-28-6-7-36-21)24(34)30-14-3-5-18(23(27)33)29-11-14/h2-9,11-12,19H,10H2,1H3,(H2,27,33)(H,30,34)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313740
PNG
(5-[(2-{4-[2-Cyano-5-(methylamino)phenyl]-5-methoxy...)
Show SMILES CNC(=O)c1ccc(NC(=O)C(CCOC)n2cc(OC)c(cc2=O)-c2cc(NC)ccc2C#N)cn1
Show InChI InChI=1S/C26H28N6O5/c1-28-17-6-5-16(13-27)19(11-17)20-12-24(33)32(15-23(20)37-4)22(9-10-36-3)26(35)31-18-7-8-21(30-14-18)25(34)29-2/h5-8,11-12,14-15,22,28H,9-10H2,1-4H3,(H,29,34)(H,31,35)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313748
PNG
(5-{[2-{4-[5-Chloro-2-(trifluoromethyl)phenyl]-5-me...)
Show SMILES COc1cn(C(Cc2ccccn2)C(=O)Nc2ccc(nc2)C(N)=O)c(=O)cc1-c1cc(Cl)ccc1C(F)(F)F
Show InChI InChI=1S/C27H21ClF3N5O4/c1-40-23-14-36(24(37)12-19(23)18-10-15(28)5-7-20(18)27(29,30)31)22(11-16-4-2-3-9-33-16)26(39)35-17-6-8-21(25(32)38)34-13-17/h2-10,12-14,22H,11H2,1H3,(H2,32,38)(H,35,39)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313709
PNG
(US10167280, Example 14)
Show SMILES COc1cn(C(Cc2cc(C)no2)C(=O)Nc2ccc(nc2)C(N)=O)c(=O)cc1-c1cc(Cl)ccc1F
Show InChI InChI=1S/C25H21ClFN5O5/c1-13-7-16(37-31-13)9-21(25(35)30-15-4-6-20(24(28)34)29-11-15)32-12-22(36-2)18(10-23(32)33)17-8-14(26)3-5-19(17)27/h3-8,10-12,21H,9H2,1-2H3,(H2,28,34)(H,30,35)
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n/an/a 390n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313748
PNG
(5-{[2-{4-[5-Chloro-2-(trifluoromethyl)phenyl]-5-me...)
Show SMILES COc1cn(C(Cc2ccccn2)C(=O)Nc2ccc(nc2)C(N)=O)c(=O)cc1-c1cc(Cl)ccc1C(F)(F)F
Show InChI InChI=1S/C27H21ClF3N5O4/c1-40-23-14-36(24(37)12-19(23)18-10-15(28)5-7-20(18)27(29,30)31)22(11-16-4-2-3-9-33-16)26(39)35-17-6-8-21(25(32)38)34-13-17/h2-10,12-14,22H,11H2,1H3,(H2,32,38)(H,35,39)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313749
PNG
(5-{[2-{4-[5-Chloro-2-(trifluoromethyl)phenyl]-5-me...)
Show SMILES COc1cn(C(Cc2cc(C)no2)C(=O)Nc2ccc(nc2)C(N)=O)c(=O)cc1-c1cc(Cl)ccc1C(F)(F)F
Show InChI InChI=1S/C26H21ClF3N5O5/c1-13-7-16(40-34-13)9-21(25(38)33-15-4-6-20(24(31)37)32-11-15)35-12-22(39-2)18(10-23(35)36)17-8-14(27)3-5-19(17)26(28,29)30/h3-8,10-12,21H,9H2,1-2H3,(H2,31,37)(H,33,38)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313705
PNG
(US10167280, Example 10)
Show SMILES NC(=O)c1ccc(NC(=O)C(Cc2cocn2)n2cc(Cl)c(cc2=O)-c2cc(Cl)ccc2C#N)cn1
Show InChI InChI=1S/C24H16Cl2N6O4/c25-14-2-1-13(8-27)17(5-14)18-7-22(33)32(10-19(18)26)21(6-16-11-36-12-30-16)24(35)31-15-3-4-20(23(28)34)29-9-15/h1-5,7,9-12,21H,6H2,(H2,28,34)(H,31,35)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313702
PNG
(US10167280, Example 7)
Show SMILES NC(=O)c1ccc(NC(=O)C(Cc2ccccn2)n2cc(OC(F)F)c(cc2=O)-c2cc(Cl)ccc2C#N)cn1
Show InChI InChI=1S/C27H19ClF2N6O4/c28-16-5-4-15(12-31)19(9-16)20-11-24(37)36(14-23(20)40-27(29)30)22(10-17-3-1-2-8-33-17)26(39)35-18-6-7-21(25(32)38)34-13-18/h1-9,11,13-14,22,27H,10H2,(H2,32,38)(H,35,39)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313707
PNG
(US10167280, Example 12)
Show SMILES NC(=O)c1ccc(NC(=O)C(Cc2cnco2)n2cc(OC(F)F)c(cc2=O)-c2cc(Cl)ccc2C#N)cn1
Show InChI InChI=1S/C25H17ClF2N6O5/c26-14-2-1-13(8-29)17(5-14)18-7-22(35)34(11-21(18)39-25(27)28)20(6-16-10-31-12-38-16)24(37)33-15-3-4-19(23(30)36)32-9-15/h1-5,7,9-12,20,25H,6H2,(H2,30,36)(H,33,37)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313704
PNG
(US10167280, Example 21 | US10167280, Example 44 | ...)
Show SMILES COc1cn(C(Cc2ccncc2)C(=O)Nc2ccc(nc2)C(N)=O)c(=O)cc1-c1cc(Cl)ccc1C#N
Show InChI InChI=1S/C27H21ClN6O4/c1-38-24-15-34(25(35)12-21(24)20-11-18(28)3-2-17(20)13-29)23(10-16-6-8-31-9-7-16)27(37)33-19-4-5-22(26(30)36)32-14-19/h2-9,11-12,14-15,23H,10H2,1H3,(H2,30,36)(H,33,37)
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n/an/a 760n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM313745
PNG
(5-({2-[4-(5-Chloro-2-cyano-3-fluorophenyl)-5-metho...)
Show SMILES COCCC(C(=O)Nc1ccc(nc1)C(N)=O)n1cc(OC)c(cc1=O)-c1cc(Cl)cc(F)c1C#N
Show InChI InChI=1S/C24H21ClFN5O5/c1-35-6-5-20(24(34)30-14-3-4-19(23(28)33)29-11-14)31-12-21(36-2)16(9-22(31)32)15-7-13(25)8-18(26)17(15)10-27/h3-4,7-9,11-12,20H,5-6H2,1-2H3,(H2,28,33)(H,30,34)
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n/an/a 1.10E+3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...


US Patent US10167280 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%