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Patent code US10167296

Compile Data Set for Download or QSAR
Found 99 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM313914
PNG
(US10167296, Example 2.25)
Show SMILES COc1c(C)c2c(Nc3ccc(F)cc3O[C@@H]3CO[C@@H]4CCO[C@H]34)ncnc2cc1N=S(C)(C)=O
Show InChI InChI=1S/C24H27FN4O5S/c1-13-21-16(10-17(22(13)31-2)29-35(3,4)30)26-12-27-24(21)28-15-6-5-14(25)9-19(15)34-20-11-33-18-7-8-32-23(18)20/h5-6,9-10,12,18,20,23H,7-8,11H2,1-4H3,(H,26,27,28)/t18-,20-,23+/m1/s1
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EVOTEC INTERNATIONAL GMBH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM313915
PNG
(US10167296, Example 2.26)
Show SMILES COc1c(C)c2c(Nc3ccc(F)cc3O[C@@H]3CO[C@@H]4[C@@H](F)CO[C@H]34)ncnc2cc1N=S1(=O)CCC1
Show InChI InChI=1S/C25H26F2N4O5S/c1-13-21-17(9-18(22(13)33-2)31-37(32)6-3-7-37)28-12-29-25(21)30-16-5-4-14(26)8-19(16)36-20-11-35-23-15(27)10-34-24(20)23/h4-5,8-9,12,15,20,23-24H,3,6-7,10-11H2,1-2H3,(H,28,29,30)/t15-,20+,23+,24+/m0/s1
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EVOTEC INTERNATIONAL GMBH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM313946
PNG
(US10167296, Example 2.57)
Show SMILES COc1c(C)c2c(Nc3ccc(F)cc3O[C@H]3CCOC3)ncnc2cc1N=S1(=O)CCC1
Show InChI InChI=1S/C23H25FN4O4S/c1-14-21-18(11-19(22(14)30-2)28-33(29)8-3-9-33)25-13-26-23(21)27-17-5-4-15(24)10-20(17)32-16-6-7-31-12-16/h4-5,10-11,13,16H,3,6-9,12H2,1-2H3,(H,25,26,27)/t16-/m0/s1
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EVOTEC INTERNATIONAL GMBH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM313895
PNG
(US10167296, Example 2.06)
Show SMILES COc1c(C)c2c(Nc3ccc(F)cc3O[C@@H]3CO[C@@H]4[C@H](O)CO[C@H]34)ncnc2cc1N=S1(=O)CCC1
Show InChI InChI=1S/C25H27FN4O6S/c1-13-21-16(9-17(22(13)33-2)30-37(32)6-3-7-37)27-12-28-25(21)29-15-5-4-14(26)8-19(15)36-20-11-35-23-18(31)10-34-24(20)23/h4-5,8-9,12,18,20,23-24,31H,3,6-7,10-11H2,1-2H3,(H,27,28,29)/t18-,20-,23-,24-/m1/s1
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EVOTEC INTERNATIONAL GMBH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM313893
PNG
(US10167296, Example 2.04)
Show SMILES COc1c(C)c2c(Nc3ccc(F)cc3O[C@@H]3CO[C@@H]4CCO[C@H]34)ncnc2cc1N=S1(=O)CCC(O)CC1
Show InChI InChI=1S/C27H31FN4O6S/c1-15-24-19(12-20(25(15)35-2)32-39(34)9-6-17(33)7-10-39)29-14-30-27(24)31-18-4-3-16(28)11-22(18)38-23-13-37-21-5-8-36-26(21)23/h3-4,11-12,14,17,21,23,26,33H,5-10,13H2,1-2H3,(H,29,30,31)/t17?,21-,23-,26+,39?/m1/s1
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EVOTEC INTERNATIONAL GMBH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM313931
PNG
(US10167296, Example 2.42)
Show SMILES COc1c(C)c2c(Nc3ccc(F)cc3O[C@@H]3CO[C@@H]4CCO[C@H]34)ncnc2cc1N=S1(=O)CCC1
Show InChI InChI=1S/C25H27FN4O5S/c1-14-22-17(11-18(23(14)32-2)30-36(31)8-3-9-36)27-13-28-25(22)29-16-5-4-15(26)10-20(16)35-21-12-34-19-6-7-33-24(19)21/h4-5,10-11,13,19,21,24H,3,6-9,12H2,1-2H3,(H,27,28,29)/t19-,21-,24+/m1/s1
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EVOTEC INTERNATIONAL GMBH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM313892
PNG
(US10167296, Example 2.03)
Show SMILES COc1c(C)c2c(Nc3ccc(F)cc3O[C@@H]3CO[C@@H]4CCO[C@H]34)ncnc2cc1N=S1(=O)CCCC1
Show InChI InChI=1S/C26H29FN4O5S/c1-15-23-18(12-19(24(15)33-2)31-37(32)9-3-4-10-37)28-14-29-26(23)30-17-6-5-16(27)11-21(17)36-22-13-35-20-7-8-34-25(20)22/h5-6,11-12,14,20,22,25H,3-4,7-10,13H2,1-2H3,(H,28,29,30)/t20-,22-,25+/m1/s1
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EVOTEC INTERNATIONAL GMBH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM313937
PNG
(US10167296, Example 2.48)
Show SMILES COc1c(C)c2c(Nc3ccc(F)cc3O[C@H]3CCOC3)ncnc2cc1N=S1(=O)CCCC1
Show InChI InChI=1S/C24H27FN4O4S/c1-15-22-19(12-20(23(15)31-2)29-34(30)9-3-4-10-34)26-14-27-24(22)28-18-6-5-16(25)11-21(18)33-17-7-8-32-13-17/h5-6,11-12,14,17H,3-4,7-10,13H2,1-2H3,(H,26,27,28)/t17-/m0/s1
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EVOTEC INTERNATIONAL GMBH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM313919
PNG
(US10167296, Example 2.30)
Show SMILES COc1c(C)c2c(Nc3ccc(F)cc3O[C@@H]3CO[C@@H]4CCO[C@H]34)ncnc2cc1N=S1(=O)CCNCC1
Show InChI InChI=1S/C26H30FN5O5S/c1-15-23-18(12-19(24(15)34-2)32-38(33)9-6-28-7-10-38)29-14-30-26(23)31-17-4-3-16(27)11-21(17)37-22-13-36-20-5-8-35-25(20)22/h3-4,11-12,14,20,22,25,28H,5-10,13H2,1-2H3,(H,29,30,31)/t20-,22-,25+/m1/s1
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EVOTEC INTERNATIONAL GMBH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM313929
PNG
(US10167296, Example 2.40)
Show SMILES COc1c(Cl)c2c(Nc3ccc(F)cc3O[C@@H]3CO[C@@H]4CCO[C@H]34)ncnc2cc1N=S(C)(C)=O
Show InChI InChI=1S/C23H24ClFN4O5S/c1-31-21-15(29-35(2,3)30)9-14-19(20(21)24)23(27-11-26-14)28-13-5-4-12(25)8-17(13)34-18-10-33-16-6-7-32-22(16)18/h4-5,8-9,11,16,18,22H,6-7,10H2,1-3H3,(H,26,27,28)/t16-,18-,22+/m1/s1
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EVOTEC INTERNATIONAL GMBH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM313907
PNG
(US10167296, Example 2.18)
Show SMILES CO[C@@H]1CO[C@@H]2[C@@H](CO[C@H]12)Oc1cc(F)ccc1Nc1ncnc2cc(N=S3(=O)CCC3)c(OC)c(Cl)c12
Show InChI InChI=1S/C25H26ClFN4O6S/c1-33-18-10-35-24-19(11-36-23(18)24)37-17-8-13(27)4-5-14(17)30-25-20-15(28-12-29-25)9-16(22(34-2)21(20)26)31-38(32)6-3-7-38/h4-5,8-9,12,18-19,23-24H,3,6-7,10-11H2,1-2H3,(H,28,29,30)/t18-,19-,23-,24-/m1/s1
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EVOTEC INTERNATIONAL GMBH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM313904
PNG
(US10167296, Example 2.15)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(N=S3(=O)CCC3)c(OCCCN3CCOCC3)c(C)c12)C(F)(F)F
Show InChI InChI=1S/C28H33F4N5O4S/c1-18-25-22(33-17-34-27(25)35-21-6-5-20(29)15-24(21)41-19(2)28(30,31)32)16-23(36-42(38)13-4-14-42)26(18)40-10-3-7-37-8-11-39-12-9-37/h5-6,15-17,19H,3-4,7-14H2,1-2H3,(H,33,34,35)/t19-/m1/s1
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EVOTEC INTERNATIONAL GMBH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM313948
PNG
(US10167296, Example 2.59)
Show SMILES COc1c(Cl)c2c(Nc3ccc(F)cc3O[C@@H]3CO[C@@H]4CCO[C@H]34)ncnc2cc1N=S1(=O)CCC1
Show InChI InChI=1S/C24H24ClFN4O5S/c1-32-22-16(30-36(31)7-2-8-36)10-15-20(21(22)25)24(28-12-27-15)29-14-4-3-13(26)9-18(14)35-19-11-34-17-5-6-33-23(17)19/h3-4,9-10,12,17,19,23H,2,5-8,11H2,1H3,(H,27,28,29)/t17-,19-,23+/m1/s1
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EVOTEC INTERNATIONAL GMBH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM313933
PNG
(US10167296, Example 2.44)
Show SMILES COc1c(C)c2c(Nc3ccc(F)cc3O[C@H]3CC[C@H](O)CC3)ncnc2cc1N=S1(=O)CCCC1
Show InChI InChI=1S/C26H31FN4O4S/c1-16-24-21(14-22(25(16)34-2)31-36(33)11-3-4-12-36)28-15-29-26(24)30-20-10-5-17(27)13-23(20)35-19-8-6-18(32)7-9-19/h5,10,13-15,18-19,32H,3-4,6-9,11-12H2,1-2H3,(H,28,29,30)/t18-,19-
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EVOTEC INTERNATIONAL GMBH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM313897
PNG
(US10167296, Example 2.08)
Show SMILES COc1c(C)c2c(Nc3ccc(F)cc3O[C@@H]3CO[C@@H]4CCO[C@H]34)ncnc2cc1N=S1(=O)CCCCC1
Show InChI InChI=1S/C27H31FN4O5S/c1-16-24-19(13-20(25(16)34-2)32-38(33)10-4-3-5-11-38)29-15-30-27(24)31-18-7-6-17(28)12-22(18)37-23-14-36-21-8-9-35-26(21)23/h6-7,12-13,15,21,23,26H,3-5,8-11,14H2,1-2H3,(H,29,30,31)/t21-,23-,26+/m1/s1
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EVOTEC INTERNATIONAL GMBH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM313936
PNG
(US10167296, Example 2.47)
Show SMILES COc1c(Cl)c2c(Nc3ccc(F)cc3O[C@H](C)C(=O)NCC(F)(F)F)ncnc2cc1N=S(C)(C)=O
Show InChI InChI=1S/C22H22ClF4N5O4S/c1-11(21(33)28-9-22(25,26)27)36-16-7-12(24)5-6-13(16)31-20-17-14(29-10-30-20)8-15(32-37(3,4)34)19(35-2)18(17)23/h5-8,10-11H,9H2,1-4H3,(H,28,33)(H,29,30,31)/t11-/m1/s1
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EVOTEC INTERNATIONAL GMBH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM313924
PNG
(US10167296, Example 2.35)
Show SMILES COc1c(C)c2c(Nc3ccc(F)cc3O[C@H](C)C(F)(F)F)ncnc2cc1N=S1(=O)CCC1
Show InChI InChI=1S/C22H22F4N4O3S/c1-12-19-16(10-17(20(12)32-3)30-34(31)7-4-8-34)27-11-28-21(19)29-15-6-5-14(23)9-18(15)33-13(2)22(24,25)26/h5-6,9-11,13H,4,7-8H2,1-3H3,(H,27,28,29)/t13-/m1/s1
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EVOTEC INTERNATIONAL GMBH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM313943
PNG
(US10167296, Example 2.54)
Show SMILES COc1c(C)c2c(Nc3ccc(F)cc3O[C@H](C)C(F)(F)F)ncnc2cc1N=S1(=O)CCCC1
Show InChI InChI=1S/C23H24F4N4O3S/c1-13-20-17(11-18(21(13)33-3)31-35(32)8-4-5-9-35)28-12-29-22(20)30-16-7-6-15(24)10-19(16)34-14(2)23(25,26)27/h6-7,10-12,14H,4-5,8-9H2,1-3H3,(H,28,29,30)/t14-/m1/s1
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EVOTEC INTERNATIONAL GMBH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM313888
PNG
(US10167296, Example 1.03)
Show SMILES CCOc1c(C)c2c(Nc3ccc(F)cc3O[C@H](C)C(F)(F)F)ncnc2cc1N=S(C)(C)=O
Show InChI InChI=1S/C22H24F4N4O3S/c1-6-32-20-12(2)19-16(10-17(20)30-34(4,5)31)27-11-28-21(19)29-15-8-7-14(23)9-18(15)33-13(3)22(24,25)26/h7-11,13H,6H2,1-5H3,(H,27,28,29)/t13-/m1/s1
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Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM313922
PNG
(US10167296, Example 2.33)
Show SMILES COc1c(Cl)c2c(Nc3ccc(F)cc3O[C@@H]3CO[C@@H]4CCO[C@H]34)ncnc2cc1N=S1(=O)CCCC1
Show InChI InChI=1S/C25H26ClFN4O5S/c1-33-23-17(31-37(32)8-2-3-9-37)11-16-21(22(23)26)25(29-13-28-16)30-15-5-4-14(27)10-19(15)36-20-12-35-18-6-7-34-24(18)20/h4-5,10-11,13,18,20,24H,2-3,6-9,12H2,1H3,(H,28,29,30)/t18-,20-,24+/m1/s1
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Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM313930
PNG
(US10167296, Example 2.41)
Show SMILES CO[C@@H]1CO[C@@H]2[C@@H](CO[C@H]12)Oc1cc(F)ccc1Nc1ncnc2cc(N=S3(=O)CCC3)c(OC)c(C)c12
Show InChI InChI=1S/C26H29FN4O6S/c1-14-22-17(10-18(23(14)34-3)31-38(32)7-4-8-38)28-13-29-26(22)30-16-6-5-15(27)9-19(16)37-21-12-36-24-20(33-2)11-35-25(21)24/h5-6,9-10,13,20-21,24-25H,4,7-8,11-12H2,1-3H3,(H,28,29,30)/t20-,21-,24-,25-/m1/s1
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Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM313942
PNG
(US10167296, Example 2.53)
Show SMILES COc1c(C)c2c(Nc3ccc(F)cc3O[C@H](C)C(=O)N[C@@H](C)C(F)(F)F)ncnc2cc1N=S1(=O)CCC1
Show InChI InChI=1S/C25H27F4N5O4S/c1-13-21-18(11-19(22(13)37-4)34-39(36)8-5-9-39)30-12-31-23(21)33-17-7-6-16(26)10-20(17)38-14(2)24(35)32-15(3)25(27,28)29/h6-7,10-12,14-15H,5,8-9H2,1-4H3,(H,32,35)(H,30,31,33)/t14-,15+/m1/s1
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Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM313944
PNG
(US10167296, Example 2.55)
Show SMILES CO[C@@H]1CO[C@@H]2[C@@H](CO[C@H]12)Oc1cc(F)ccc1Nc1ncnc2cc(N=S3(=O)CCCC3)c(OC)c(Cl)c12
Show InChI InChI=1S/C26H28ClFN4O6S/c1-34-19-11-36-25-20(12-37-24(19)25)38-18-9-14(28)5-6-15(18)31-26-21-16(29-13-30-26)10-17(23(35-2)22(21)27)32-39(33)7-3-4-8-39/h5-6,9-10,13,19-20,24-25H,3-4,7-8,11-12H2,1-2H3,(H,29,30,31)/t19-,20-,24-,25-/m1/s1
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Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM313934
PNG
(US10167296, Example 2.45)
Show SMILES CO[C@@H]1CO[C@@H]2[C@@H](CO[C@H]12)Oc1cc(F)ccc1Nc1ncnc2cc(N=S(C)(C)=O)c(OC)c(C)c12
Show InChI InChI=1S/C25H29FN4O6S/c1-13-21-16(9-17(22(13)33-3)30-37(4,5)31)27-12-28-25(21)29-15-7-6-14(26)8-18(15)36-20-11-35-23-19(32-2)10-34-24(20)23/h6-9,12,19-20,23-24H,10-11H2,1-5H3,(H,27,28,29)/t19-,20-,23-,24-/m1/s1
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Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM313902
PNG
(US10167296, Example 2.13)
Show SMILES COc1c(C)c2c(Nc3ccc(F)cc3O[C@@H]3CO[C@@H]4[C@H](O)CO[C@H]34)ncnc2cc1N=S(C)(C)=O
Show InChI InChI=1S/C24H27FN4O6S/c1-12-20-15(8-16(21(12)32-2)29-36(3,4)31)26-11-27-24(20)28-14-6-5-13(25)7-18(14)35-19-10-34-22-17(30)9-33-23(19)22/h5-8,11,17,19,22-23,30H,9-10H2,1-4H3,(H,26,27,28)/t17-,19-,22-,23-/m1/s1
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Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM313898
PNG
(US10167296, Example 2.09)
Show SMILES COc1c(C)c2c(Nc3ccc(F)cc3O[C@@H]3CO[C@@H]4[C@H](O)CO[C@H]34)ncnc2cc1N=S1(=O)CCCC1
Show InChI InChI=1S/C26H29FN4O6S/c1-14-22-17(10-18(23(14)34-2)31-38(33)7-3-4-8-38)28-13-29-26(22)30-16-6-5-15(27)9-20(16)37-21-12-36-24-19(32)11-35-25(21)24/h5-6,9-10,13,19,21,24-25,32H,3-4,7-8,11-12H2,1-2H3,(H,28,29,30)/t19-,21-,24-,25-/m1/s1
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Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM313925
PNG
(US10167296, Example 2.36)
Show SMILES CO[C@@H]1CO[C@@H]2[C@@H](CO[C@H]12)Oc1cc(F)ccc1Nc1ncnc2cc(N=S3(=O)CCCC3)c(OC)c(C)c12
Show InChI InChI=1S/C27H31FN4O6S/c1-15-23-18(11-19(24(15)35-3)32-39(33)8-4-5-9-39)29-14-30-27(23)31-17-7-6-16(28)10-20(17)38-22-13-37-25-21(34-2)12-36-26(22)25/h6-7,10-11,14,21-22,25-26H,4-5,8-9,12-13H2,1-3H3,(H,29,30,31)/t21-,22-,25-,26-/m1/s1
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Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM313910
PNG
(US10167296, Example 2.21)
Show SMILES COc1c(C)c2c(Nc3cccnc3O[C@@H]3CO[C@@H]4CCO[C@H]34)ncnc2cc1N=S1(=O)CCC1
Show InChI InChI=1S/C24H27N5O5S/c1-14-20-16(11-17(21(14)31-2)29-35(30)9-4-10-35)26-13-27-23(20)28-15-5-3-7-25-24(15)34-19-12-33-18-6-8-32-22(18)19/h3,5,7,11,13,18-19,22H,4,6,8-10,12H2,1-2H3,(H,26,27,28)/t18-,19-,22+/m1/s1
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Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM313900
PNG
(US10167296, Example 2.11)
Show SMILES COc1c(C)c2c(Nc3ccc(F)cc3O[C@H](C)C(=O)NCC(F)(F)F)ncnc2cc1N=S1(=O)CCC1
Show InChI InChI=1S/C24H25F4N5O4S/c1-13-20-17(10-18(21(13)36-3)33-38(35)7-4-8-38)30-12-31-22(20)32-16-6-5-15(25)9-19(16)37-14(2)23(34)29-11-24(26,27)28/h5-6,9-10,12,14H,4,7-8,11H2,1-3H3,(H,29,34)(H,30,31,32)/t14-/m1/s1
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Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM313923
PNG
(US10167296, Example 2.34)
Show SMILES COc1c(Cl)c2c(Nc3ccc(F)cc3OC3CCOCC3)ncnc2cc1N=S(C)(C)=O
Show InChI InChI=1S/C22H24ClFN4O4S/c1-30-21-17(28-33(2,3)29)11-16-19(20(21)23)22(26-12-25-16)27-15-5-4-13(24)10-18(15)32-14-6-8-31-9-7-14/h4-5,10-12,14H,6-9H2,1-3H3,(H,25,26,27)
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Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM313939
PNG
(US10167296, Example 2.50)
Show SMILES COc1c(C)c2c(Nc3ccc(F)cc3O[C@H]3CCOC3)ncnc2cc1N=S(C)(C)=O
Show InChI InChI=1S/C22H25FN4O4S/c1-13-20-17(10-18(21(13)29-2)27-32(3,4)28)24-12-25-22(20)26-16-6-5-14(23)9-19(16)31-15-7-8-30-11-15/h5-6,9-10,12,15H,7-8,11H2,1-4H3,(H,24,25,26)/t15-/m0/s1
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Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM313935
PNG
(US10167296, Example 2.46)
Show SMILES COc1c(C)c2c(Nc3ccc(F)cc3O[C@H]3COC[C@@H]3O)ncnc2cc1N=S1(=O)CCCC1
Show InChI InChI=1S/C24H27FN4O5S/c1-14-22-17(10-18(23(14)32-2)29-35(31)7-3-4-8-35)26-13-27-24(22)28-16-6-5-15(25)9-20(16)34-21-12-33-11-19(21)30/h5-6,9-10,13,19,21,30H,3-4,7-8,11-12H2,1-2H3,(H,26,27,28)/t19-,21-/m0/s1
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Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM313927
PNG
(US10167296, Example 2.38)
Show SMILES COc1c(C)c2c(Nc3ccc(F)cc3O[C@H]3COC[C@@H]3O)ncnc2cc1N=S(C)(C)=O
Show InChI InChI=1S/C22H25FN4O5S/c1-12-20-15(8-16(21(12)30-2)27-33(3,4)29)24-11-25-22(20)26-14-6-5-13(23)7-18(14)32-19-10-31-9-17(19)28/h5-8,11,17,19,28H,9-10H2,1-4H3,(H,24,25,26)/t17-,19-/m0/s1
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Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM313912
PNG
(US10167296, Example 2.23)
Show SMILES COc1c(C)c2c(Nc3ccc(F)cc3O[C@@H]3CO[C@@H]4CCO[C@H]34)ncnc2cc1N=S(C)(=O)CCO
Show InChI InChI=1S/C25H29FN4O6S/c1-14-22-17(11-18(23(14)33-2)30-37(3,32)9-7-31)27-13-28-25(22)29-16-5-4-15(26)10-20(16)36-21-12-35-19-6-8-34-24(19)21/h4-5,10-11,13,19,21,24,31H,6-9,12H2,1-3H3,(H,27,28,29)/t19-,21-,24+,37?/m1/s1
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Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM313920
PNG
(US10167296, Example 2.31)
Show SMILES COc1c(C)c2c(Nc3ccc(F)cc3O[C@@H]3CO[C@@H]4CCO[C@H]34)ncnc2cc1N=S(C)(=O)C(C)C
Show InChI InChI=1S/C26H31FN4O5S/c1-14(2)37(5,32)31-19-11-18-23(15(3)24(19)33-4)26(29-13-28-18)30-17-7-6-16(27)10-21(17)36-22-12-35-20-8-9-34-25(20)22/h6-7,10-11,13-14,20,22,25H,8-9,12H2,1-5H3,(H,28,29,30)/t20-,22-,25+,37?/m1/s1
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EVOTEC INTERNATIONAL GMBH

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Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM313906
PNG
(US10167296, Example 2.17)
Show SMILES COc1c(C)c2c(Nc3ccc(F)cc3O[C@@H]3CO[C@@H]4CCO[C@H]34)ncnc2cc1N=S1(=O)CCOCC1
Show InChI InChI=1S/C26H29FN4O6S/c1-15-23-18(12-19(24(15)33-2)31-38(32)9-7-34-8-10-38)28-14-29-26(23)30-17-4-3-16(27)11-21(17)37-22-13-36-20-5-6-35-25(20)22/h3-4,11-12,14,20,22,25H,5-10,13H2,1-2H3,(H,28,29,30)/t20-,22-,25+/m1/s1
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Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM313952
PNG
(US10167296, Example 3.04)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(N=S(C)(C)=O)c(OC3CCOC3)c(C)c12)C(F)(F)F
Show InChI InChI=1S/C24H26F4N4O4S/c1-13-21-18(10-19(32-37(3,4)33)22(13)36-16-7-8-34-11-16)29-12-30-23(21)31-17-6-5-15(25)9-20(17)35-14(2)24(26,27)28/h5-6,9-10,12,14,16H,7-8,11H2,1-4H3,(H,29,30,31)/t14-,16?/m1/s1
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Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM313917
PNG
(US10167296, Example 2.28)
Show SMILES CO[C@@H]1CO[C@@H]2[C@@H](CO[C@H]12)Oc1cc(F)ccc1Nc1ncnc2cc(N=S(C)(C)=O)c(OC)c(Cl)c12
Show InChI InChI=1S/C24H26ClFN4O6S/c1-32-17-9-34-23-18(10-35-22(17)23)36-16-7-12(26)5-6-13(16)29-24-19-14(27-11-28-24)8-15(30-37(3,4)31)21(33-2)20(19)25/h5-8,11,17-18,22-23H,9-10H2,1-4H3,(H,27,28,29)/t17-,18-,22-,23-/m1/s1
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US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM313938
PNG
(US10167296, Example 2.49)
Show SMILES COc1c(C)c2c(Nc3cccnc3O[C@@H]3CO[C@@H]4CCO[C@H]34)ncnc2cc1N=S(C)(C)=O
Show InChI InChI=1S/C23H27N5O5S/c1-13-19-15(10-16(20(13)30-2)28-34(3,4)29)25-12-26-22(19)27-14-6-5-8-24-23(14)33-18-11-32-17-7-9-31-21(17)18/h5-6,8,10,12,17-18,21H,7,9,11H2,1-4H3,(H,25,26,27)/t17-,18-,21+/m1/s1
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Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM313901
PNG
(US10167296, Example 2.12)
Show SMILES COc1c(C)c2c(Nc3ccc(F)cc3O[C@@H]3CO[C@@H]4CCO[C@H]34)ncnc2cc1N=S(C)(=O)C1CCOCC1
Show InChI InChI=1S/C28H33FN4O6S/c1-16-25-20(13-21(26(16)35-2)33-40(3,34)18-6-9-36-10-7-18)30-15-31-28(25)32-19-5-4-17(29)12-23(19)39-24-14-38-22-8-11-37-27(22)24/h4-5,12-13,15,18,22,24,27H,6-11,14H2,1-3H3,(H,30,31,32)/t22-,24-,27+,40?/m1/s1
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Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM313941
PNG
(US10167296, Example 2.52)
Show SMILES COc1c(C)c2c(Nc3ccc(F)cc3O[C@H](C)C(=O)NCC(F)(F)F)ncnc2cc1N=S1(=O)CCCC1
Show InChI InChI=1S/C25H27F4N5O4S/c1-14-21-18(11-19(22(14)37-3)34-39(36)8-4-5-9-39)31-13-32-23(21)33-17-7-6-16(26)10-20(17)38-15(2)24(35)30-12-25(27,28)29/h6-7,10-11,13,15H,4-5,8-9,12H2,1-3H3,(H,30,35)(H,31,32,33)/t15-/m1/s1
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Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM313932
PNG
(US10167296, Example 2.43)
Show SMILES COc1c(C)c2c(Nc3ccc(F)cc3O[C@@H]3CO[C@@H]4CCO[C@H]34)ncnc2cc1N=S(C)(=O)C1CC1
Show InChI InChI=1S/C26H29FN4O5S/c1-14-23-18(11-19(24(14)33-2)31-37(3,32)16-5-6-16)28-13-29-26(23)30-17-7-4-15(27)10-21(17)36-22-12-35-20-8-9-34-25(20)22/h4,7,10-11,13,16,20,22,25H,5-6,8-9,12H2,1-3H3,(H,28,29,30)/t20-,22-,25+,37?/m1/s1
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Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM313947
PNG
(US10167296, Example 2.58)
Show SMILES COc1c(C)c2c(Nc3ccc(F)cc3O[C@H]3CC[C@H](O)CC3)ncnc2cc1N=S1(=O)CCC1
Show InChI InChI=1S/C25H29FN4O4S/c1-15-23-20(13-21(24(15)33-2)30-35(32)10-3-11-35)27-14-28-25(23)29-19-9-4-16(26)12-22(19)34-18-7-5-17(31)6-8-18/h4,9,12-14,17-18,31H,3,5-8,10-11H2,1-2H3,(H,27,28,29)/t17-,18-
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Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM313887
PNG
(US10167296, Example 1.02)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(N=S(C)(C)=O)c(OCCCN3CCCC3)c(C)c12)C(F)(F)F
Show InChI InChI=1S/C27H33F4N5O3S/c1-17-24-21(15-22(35-40(3,4)37)25(17)38-13-7-12-36-10-5-6-11-36)32-16-33-26(24)34-20-9-8-19(28)14-23(20)39-18(2)27(29,30)31/h8-9,14-16,18H,5-7,10-13H2,1-4H3,(H,32,33,34)/t18-/m1/s1
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Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM313928
PNG
(US10167296, Example 2.39)
Show SMILES COc1c(C)c2c(Nc3ccc(Cl)cc3O[C@H](C)C(=O)NCC(F)(F)F)ncnc2cc1N=S1(=O)CCC1
Show InChI InChI=1S/C24H25ClF3N5O4S/c1-13-20-17(10-18(21(13)36-3)33-38(35)7-4-8-38)30-12-31-22(20)32-16-6-5-15(25)9-19(16)37-14(2)23(34)29-11-24(26,27)28/h5-6,9-10,12,14H,4,7-8,11H2,1-3H3,(H,29,34)(H,30,31,32)/t14-/m1/s1
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Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM313889
PNG
(US10167296, Example 1.04)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(N=S(C)(C)=O)c(OCCN3CCOCC3)c(C)c12)C(F)(F)F
Show InChI InChI=1S/C26H31F4N5O4S/c1-16-23-20(14-21(34-40(3,4)36)24(16)38-12-9-35-7-10-37-11-8-35)31-15-32-25(23)33-19-6-5-18(27)13-22(19)39-17(2)26(28,29)30/h5-6,13-15,17H,7-12H2,1-4H3,(H,31,32,33)/t17-/m1/s1
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Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM313911
PNG
(US10167296, Example 2.22)
Show SMILES COc1c(C)c2c(Nc3ccc(F)cc3O[C@H]3CC[C@H](O)CC3)ncnc2cc1N=S(C)(C)=O
Show InChI InChI=1S/C24H29FN4O4S/c1-14-22-19(12-20(23(14)32-2)29-34(3,4)31)26-13-27-24(22)28-18-10-5-15(25)11-21(18)33-17-8-6-16(30)7-9-17/h5,10-13,16-17,30H,6-9H2,1-4H3,(H,26,27,28)/t16-,17-
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Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM313890
PNG
(US10167296, Example 2.01)
Show SMILES COC1CS(=O)(C1)=Nc1cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)NCC(F)(F)F)c2c(C)c1OC
Show InChI InChI=1S/C25H27F4N5O5S/c1-13-21-18(8-19(22(13)38-4)34-40(36)9-16(10-40)37-3)31-12-32-23(21)33-17-6-5-15(26)7-20(17)39-14(2)24(35)30-11-25(27,28)29/h5-8,12,14,16H,9-11H2,1-4H3,(H,30,35)(H,31,32,33)/t14-,16?,40?/m1/s1
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Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM313894
PNG
(US10167296, Example 2.05)
Show SMILES COc1c(C)c2c(Nc3ccc(F)cc3O[C@H](C)C(=O)N[C@@H](C)C(F)(F)F)ncnc2cc1N=S1(=O)CCCC1
Show InChI InChI=1S/C26H29F4N5O4S/c1-14-22-19(12-20(23(14)38-4)35-40(37)9-5-6-10-40)31-13-32-24(22)34-18-8-7-17(27)11-21(18)39-15(2)25(36)33-16(3)26(28,29)30/h7-8,11-13,15-16H,5-6,9-10H2,1-4H3,(H,33,36)(H,31,32,34)/t15-,16+/m1/s1
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Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM313918
PNG
(US10167296, Example 2.29)
Show SMILES COc1c(C)c2c(Nc3ccc(Cl)cc3O[C@H](C)C(=O)NCC(F)(F)F)ncnc2cc1N=S(C)(C)=O
Show InChI InChI=1S/C23H25ClF3N5O4S/c1-12-19-16(9-17(20(12)35-3)32-37(4,5)34)29-11-30-21(19)31-15-7-6-14(24)8-18(15)36-13(2)22(33)28-10-23(25,26)27/h6-9,11,13H,10H2,1-5H3,(H,28,33)(H,29,30,31)/t13-/m1/s1
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Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM313950
PNG
(US10167296, Example 3.02)
Show SMILES COCCOc1c(C)c2c(Nc3ccc(F)cc3O[C@H](C)C(F)(F)F)ncnc2cc1N=S(C)(C)=O
Show InChI InChI=1S/C23H26F4N4O4S/c1-13-20-17(11-18(31-36(4,5)32)21(13)34-9-8-33-3)28-12-29-22(20)30-16-7-6-15(24)10-19(16)35-14(2)23(25,26)27/h6-7,10-12,14H,8-9H2,1-5H3,(H,28,29,30)/t14-/m1/s1
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Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM313896
PNG
(US10167296, Example 2.07)
Show SMILES COc1c(C)c2c(Nc3ccc(F)cc3O[C@H]3COC[C@@H]3O)ncnc2cc1N=S1(=O)CCC1
Show InChI InChI=1S/C23H25FN4O5S/c1-13-21-16(9-17(22(13)31-2)28-34(30)6-3-7-34)25-12-26-23(21)27-15-5-4-14(24)8-19(15)33-20-11-32-10-18(20)29/h4-5,8-9,12,18,20,29H,3,6-7,10-11H2,1-2H3,(H,25,26,27)/t18-,20-/m0/s1
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Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM313945
PNG
(US10167296, Example 2.56)
Show SMILES COc1c(C)c2c(Nc3ccc(Cl)cc3O[C@H](C)C(=O)NCC(F)(F)F)ncnc2cc1N=S1(=O)CCCC1
Show InChI InChI=1S/C25H27ClF3N5O4S/c1-14-21-18(11-19(22(14)37-3)34-39(36)8-4-5-9-39)31-13-32-23(21)33-17-7-6-16(26)10-20(17)38-15(2)24(35)30-12-25(27,28)29/h6-7,10-11,13,15H,4-5,8-9,12H2,1-3H3,(H,30,35)(H,31,32,33)/t15-/m1/s1
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Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM313908
PNG
(US10167296, Example 2.19)
Show SMILES COc1c(C)c2c(Nc3ccc(F)cc3O[C@@H]3CO[C@@H]4CCO[C@H]34)ncnc2cc1N=S(C)(=O)C(C)(C)C
Show InChI InChI=1S/C27H33FN4O5S/c1-15-23-18(12-19(24(15)34-5)32-38(6,33)27(2,3)4)29-14-30-26(23)31-17-8-7-16(28)11-21(17)37-22-13-36-20-9-10-35-25(20)22/h7-8,11-12,14,20,22,25H,9-10,13H2,1-6H3,(H,29,30,31)/t20-,22-,25+,38?/m1/s1
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Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM313899
PNG
(US10167296, Example 2.10)
Show SMILES COc1c(C)c2c(Nc3cccnc3O[C@@H]3CO[C@@H]4CCO[C@H]34)ncnc2cc1N=S1(=O)CCCC1
Show InChI InChI=1S/C25H29N5O5S/c1-15-21-17(12-18(22(15)32-2)30-36(31)10-3-4-11-36)27-14-28-24(21)29-16-6-5-8-26-25(16)35-20-13-34-19-7-9-33-23(19)20/h5-6,8,12,14,19-20,23H,3-4,7,9-11,13H2,1-2H3,(H,27,28,29)/t19-,20-,23+/m1/s1
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Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM313949
PNG
(US10167296, Example 3.01)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(N=S(C)(C)=O)c(OCC3CC3)c(C)c12)C(F)(F)F
Show InChI InChI=1S/C24H26F4N4O3S/c1-13-21-18(10-19(32-36(3,4)33)22(13)34-11-15-5-6-15)29-12-30-23(21)31-17-8-7-16(25)9-20(17)35-14(2)24(26,27)28/h7-10,12,14-15H,5-6,11H2,1-4H3,(H,29,30,31)/t14-/m1/s1
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Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM313905
PNG
(US10167296, Example 2.16)
Show SMILES COc1c(C)c2c(Nc3ccc(F)cc3O[C@H](C)C(F)(F)F)ncnc2cc1N=S(C)(C)=O
Show InChI InChI=1S/C21H22F4N4O3S/c1-11-18-15(9-16(19(11)31-3)29-33(4,5)30)26-10-27-20(18)28-14-7-6-13(22)8-17(14)32-12(2)21(23,24)25/h6-10,12H,1-5H3,(H,26,27,28)/t12-/m1/s1
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Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM313903
PNG
(US10167296, Example 2.14)
Show SMILES COc1c(C)c2c(Nc3ccc(F)cc3OC3CCOCC3)ncnc2cc1N=S(C)(C)=O
Show InChI InChI=1S/C23H27FN4O4S/c1-14-21-18(12-19(22(14)30-2)28-33(3,4)29)25-13-26-23(21)27-17-6-5-15(24)11-20(17)32-16-7-9-31-10-8-16/h5-6,11-13,16H,7-10H2,1-4H3,(H,25,26,27)
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Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM313909
PNG
(US10167296, Example 2.20)
Show SMILES COc1c(cc2ncnc(Nc3cc4cn[nH]c4cc3OC(C)C)c2c1C)N=S(C)(C)=O
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Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM313916
PNG
(US10167296, Example 2.27)
Show SMILES COc1c(C)c2c(Nc3cc4cn[nH]c4cc3OC(C)C)ncnc2cc1N=S1(=O)CCC1
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Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM313926
PNG
(US10167296, Example 2.37)
Show SMILES COc1c(C)c2c(Nc3ccc(F)cc3O[C@H](C)C(=O)N[C@@H](C)C(F)(F)F)ncnc2cc1N=S(C)(C)=O
Show InChI InChI=1S/C24H27F4N5O4S/c1-12-20-17(10-18(21(12)36-4)33-38(5,6)35)29-11-30-22(20)32-16-8-7-15(25)9-19(16)37-13(2)23(34)31-14(3)24(26,27)28/h7-11,13-14H,1-6H3,(H,31,34)(H,29,30,32)/t13-,14+/m1/s1
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Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM313921
PNG
(US10167296, Example 2.32)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(N=S(C)(C)=O)c(OCCN3CCN(C)C(=O)C3)c(C)c12)C(F)(F)F
Show InChI InChI=1S/C27H32F4N6O4S/c1-16-24-20(13-21(35-42(4,5)39)25(16)40-11-10-37-9-8-36(3)23(38)14-37)32-15-33-26(24)34-19-7-6-18(28)12-22(19)41-17(2)27(29,30)31/h6-7,12-13,15,17H,8-11,14H2,1-5H3,(H,32,33,34)/t17-/m1/s1
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Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM313913
PNG
(US10167296, Example 2.24)
Show SMILES COc1c(C)c2c(Nc3ccc(F)cc3O[C@H](C)C(=O)NCC(F)(F)F)ncnc2cc1N=S(C)(C)=O
Show InChI InChI=1S/C23H25F4N5O4S/c1-12-19-16(9-17(20(12)35-3)32-37(4,5)34)29-11-30-21(19)31-15-7-6-14(24)8-18(15)36-13(2)22(33)28-10-23(25,26)27/h6-9,11,13H,10H2,1-5H3,(H,28,33)(H,29,30,31)/t13-/m1/s1
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Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM313886
PNG
(US10167296, Example 1.01)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(N=S(C)(C)=O)c(OCCCN3CCN(C)C(=O)C3)c(C)c12)C(F)(F)F
Show InChI InChI=1S/C28H34F4N6O4S/c1-17-25-21(33-16-34-27(25)35-20-8-7-19(29)13-23(20)42-18(2)28(30,31)32)14-22(36-43(4,5)40)26(17)41-12-6-9-38-11-10-37(3)24(39)15-38/h7-8,13-14,16,18H,6,9-12,15H2,1-5H3,(H,33,34,35)/t18-/m1/s1
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Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM313951
PNG
(US10167296, Example 3.03)
Show SMILES CC(C)Oc1c(C)c2c(Nc3ccc(F)cc3O[C@H](C)C(F)(F)F)ncnc2cc1N=S(C)(C)=O
Show InChI InChI=1S/C23H26F4N4O3S/c1-12(2)33-21-13(3)20-17(10-18(21)31-35(5,6)32)28-11-29-22(20)30-16-8-7-15(24)9-19(16)34-14(4)23(25,26)27/h7-12,14H,1-6H3,(H,28,29,30)/t14-/m1/s1
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Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM313940
PNG
(US10167296, Example 2.51)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(N=S(C)(C)=O)c(O)c(C)c12)C(F)(F)F
Show InChI InChI=1S/C20H20F4N4O3S/c1-10-17-14(8-15(18(10)29)28-32(3,4)30)25-9-26-19(17)27-13-6-5-12(21)7-16(13)31-11(2)20(22,23)24/h5-9,11,29H,1-4H3,(H,25,26,27)/t11-/m1/s1
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Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM313891
PNG
(US10167296, Example 2.02)
Show SMILES COc1c(C)c2c(Nc3ccc(F)cc3O[C@@H]3CO[C@@H]4[C@@H](F)CO[C@H]34)ncnc2cc1N=S(C)(C)=O
Show InChI InChI=1S/C24H26F2N4O5S/c1-12-20-16(8-17(21(12)32-2)30-36(3,4)31)27-11-28-24(20)29-15-6-5-13(25)7-18(15)35-19-10-34-22-14(26)9-33-23(19)22/h5-8,11,14,19,22-23H,9-10H2,1-4H3,(H,27,28,29)/t14-,19+,22+,23+/m0/s1
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Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM313898
PNG
(US10167296, Example 2.09)
Show SMILES COc1c(C)c2c(Nc3ccc(F)cc3O[C@@H]3CO[C@@H]4[C@H](O)CO[C@H]34)ncnc2cc1N=S1(=O)CCCC1
Show InChI InChI=1S/C26H29FN4O6S/c1-14-22-17(10-18(23(14)34-2)31-38(33)7-3-4-8-38)28-13-29-26(22)30-16-6-5-15(27)9-20(16)37-21-12-36-24-19(32)11-35-25(21)24/h5-6,9-10,13,19,21,24-25,32H,3-4,7-8,11-12H2,1-2H3,(H,28,29,30)/t19-,21-,24-,25-/m1/s1
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Assay Description
The Z′-LYTEŽ biochemical assay employs a fluorescence-based, coupled-enzyme format and is based on the differential sensitivity of phosphorylat...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM313925
PNG
(US10167296, Example 2.36)
Show SMILES CO[C@@H]1CO[C@@H]2[C@@H](CO[C@H]12)Oc1cc(F)ccc1Nc1ncnc2cc(N=S3(=O)CCCC3)c(OC)c(C)c12
Show InChI InChI=1S/C27H31FN4O6S/c1-15-23-18(11-19(24(15)35-3)32-39(33)8-4-5-9-39)29-14-30-27(23)31-17-7-6-16(28)10-20(17)38-22-13-37-25-21(34-2)12-36-26(22)25/h6-7,10-11,14,21-22,25-26H,4-5,8-9,12-13H2,1-3H3,(H,29,30,31)/t21-,22-,25-,26-/m1/s1
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Assay Description
The Z′-LYTEŽ biochemical assay employs a fluorescence-based, coupled-enzyme format and is based on the differential sensitivity of phosphorylat...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM313929
PNG
(US10167296, Example 2.40)
Show SMILES COc1c(Cl)c2c(Nc3ccc(F)cc3O[C@@H]3CO[C@@H]4CCO[C@H]34)ncnc2cc1N=S(C)(C)=O
Show InChI InChI=1S/C23H24ClFN4O5S/c1-31-21-15(29-35(2,3)30)9-14-19(20(21)24)23(27-11-26-14)28-13-5-4-12(25)8-17(13)34-18-10-33-16-6-7-32-22(16)18/h4-5,8-9,11,16,18,22H,6-7,10H2,1-3H3,(H,26,27,28)/t16-,18-,22+/m1/s1
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Assay Description
The Z′-LYTEŽ biochemical assay employs a fluorescence-based, coupled-enzyme format and is based on the differential sensitivity of phosphorylat...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM313934
PNG
(US10167296, Example 2.45)
Show SMILES CO[C@@H]1CO[C@@H]2[C@@H](CO[C@H]12)Oc1cc(F)ccc1Nc1ncnc2cc(N=S(C)(C)=O)c(OC)c(C)c12
Show InChI InChI=1S/C25H29FN4O6S/c1-13-21-16(9-17(22(13)33-3)30-37(4,5)31)27-12-28-25(21)29-15-7-6-14(26)8-18(15)36-20-11-35-23-19(32-2)10-34-24(20)23/h6-9,12,19-20,23-24H,10-11H2,1-5H3,(H,27,28,29)/t19-,20-,23-,24-/m1/s1
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Assay Description
The Z′-LYTEŽ biochemical assay employs a fluorescence-based, coupled-enzyme format and is based on the differential sensitivity of phosphorylat...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM313914
PNG
(US10167296, Example 2.25)
Show SMILES COc1c(C)c2c(Nc3ccc(F)cc3O[C@@H]3CO[C@@H]4CCO[C@H]34)ncnc2cc1N=S(C)(C)=O
Show InChI InChI=1S/C24H27FN4O5S/c1-13-21-16(10-17(22(13)31-2)29-35(3,4)30)26-12-27-24(21)28-15-6-5-14(25)9-19(15)34-20-11-33-18-7-8-32-23(18)20/h5-6,9-10,12,18,20,23H,7-8,11H2,1-4H3,(H,26,27,28)/t18-,20-,23+/m1/s1
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Assay Description
The Z′-LYTEŽ biochemical assay employs a fluorescence-based, coupled-enzyme format and is based on the differential sensitivity of phosphorylat...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM313895
PNG
(US10167296, Example 2.06)
Show SMILES COc1c(C)c2c(Nc3ccc(F)cc3O[C@@H]3CO[C@@H]4[C@H](O)CO[C@H]34)ncnc2cc1N=S1(=O)CCC1
Show InChI InChI=1S/C25H27FN4O6S/c1-13-21-16(9-17(22(13)33-2)30-37(32)6-3-7-37)27-12-28-25(21)29-15-5-4-14(26)8-19(15)36-20-11-35-23-18(31)10-34-24(20)23/h4-5,8-9,12,18,20,23-24,31H,3,6-7,10-11H2,1-2H3,(H,27,28,29)/t18-,20-,23-,24-/m1/s1
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Assay Description
The Z′-LYTEŽ biochemical assay employs a fluorescence-based, coupled-enzyme format and is based on the differential sensitivity of phosphorylat...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM313937
PNG
(US10167296, Example 2.48)
Show SMILES COc1c(C)c2c(Nc3ccc(F)cc3O[C@H]3CCOC3)ncnc2cc1N=S1(=O)CCCC1
Show InChI InChI=1S/C24H27FN4O4S/c1-15-22-19(12-20(23(15)31-2)29-34(30)9-3-4-10-34)26-14-27-24(22)28-18-6-5-16(25)11-21(18)33-17-7-8-32-13-17/h5-6,11-12,14,17H,3-4,7-10,13H2,1-2H3,(H,26,27,28)/t17-/m0/s1
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Assay Description
The Z′-LYTEŽ biochemical assay employs a fluorescence-based, coupled-enzyme format and is based on the differential sensitivity of phosphorylat...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM313946
PNG
(US10167296, Example 2.57)
Show SMILES COc1c(C)c2c(Nc3ccc(F)cc3O[C@H]3CCOC3)ncnc2cc1N=S1(=O)CCC1
Show InChI InChI=1S/C23H25FN4O4S/c1-14-21-18(11-19(22(14)30-2)28-33(29)8-3-9-33)25-13-26-23(21)27-17-5-4-15(24)10-20(17)32-16-6-7-31-12-16/h4-5,10-11,13,16H,3,6-9,12H2,1-2H3,(H,25,26,27)/t16-/m0/s1
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Assay Description
The Z′-LYTEŽ biochemical assay employs a fluorescence-based, coupled-enzyme format and is based on the differential sensitivity of phosphorylat...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM313891
PNG
(US10167296, Example 2.02)
Show SMILES COc1c(C)c2c(Nc3ccc(F)cc3O[C@@H]3CO[C@@H]4[C@@H](F)CO[C@H]34)ncnc2cc1N=S(C)(C)=O
Show InChI InChI=1S/C24H26F2N4O5S/c1-12-20-16(8-17(21(12)32-2)30-36(3,4)31)27-11-28-24(20)29-15-6-5-13(25)7-18(15)35-19-10-34-22-14(26)9-33-23(19)22/h5-8,11,14,19,22-23H,9-10H2,1-4H3,(H,27,28,29)/t14-,19+,22+,23+/m0/s1
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Assay Description
The Z′-LYTEŽ biochemical assay employs a fluorescence-based, coupled-enzyme format and is based on the differential sensitivity of phosphorylat...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM313936
PNG
(US10167296, Example 2.47)
Show SMILES COc1c(Cl)c2c(Nc3ccc(F)cc3O[C@H](C)C(=O)NCC(F)(F)F)ncnc2cc1N=S(C)(C)=O
Show InChI InChI=1S/C22H22ClF4N5O4S/c1-11(21(33)28-9-22(25,26)27)36-16-7-12(24)5-6-13(16)31-20-17-14(29-10-30-20)8-15(32-37(3,4)34)19(35-2)18(17)23/h5-8,10-11H,9H2,1-4H3,(H,28,33)(H,29,30,31)/t11-/m1/s1
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Assay Description
The Z′-LYTEŽ biochemical assay employs a fluorescence-based, coupled-enzyme format and is based on the differential sensitivity of phosphorylat...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM313910
PNG
(US10167296, Example 2.21)
Show SMILES COc1c(C)c2c(Nc3cccnc3O[C@@H]3CO[C@@H]4CCO[C@H]34)ncnc2cc1N=S1(=O)CCC1
Show InChI InChI=1S/C24H27N5O5S/c1-14-20-16(11-17(21(14)31-2)29-35(30)9-4-10-35)26-13-27-23(20)28-15-5-3-7-25-24(15)34-19-12-33-18-6-8-32-22(18)19/h3,5,7,11,13,18-19,22H,4,6,8-10,12H2,1-2H3,(H,26,27,28)/t18-,19-,22+/m1/s1
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Assay Description
The Z′-LYTEŽ biochemical assay employs a fluorescence-based, coupled-enzyme format and is based on the differential sensitivity of phosphorylat...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM313935
PNG
(US10167296, Example 2.46)
Show SMILES COc1c(C)c2c(Nc3ccc(F)cc3O[C@H]3COC[C@@H]3O)ncnc2cc1N=S1(=O)CCCC1
Show InChI InChI=1S/C24H27FN4O5S/c1-14-22-17(10-18(23(14)32-2)29-35(31)7-3-4-8-35)26-13-27-24(22)28-16-6-5-15(25)9-20(16)34-21-12-33-11-19(21)30/h5-6,9-10,13,19,21,30H,3-4,7-8,11-12H2,1-2H3,(H,26,27,28)/t19-,21-/m0/s1
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Assay Description
The Z′-LYTEŽ biochemical assay employs a fluorescence-based, coupled-enzyme format and is based on the differential sensitivity of phosphorylat...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM313947
PNG
(US10167296, Example 2.58)
Show SMILES COc1c(C)c2c(Nc3ccc(F)cc3O[C@H]3CC[C@H](O)CC3)ncnc2cc1N=S1(=O)CCC1
Show InChI InChI=1S/C25H29FN4O4S/c1-15-23-20(13-21(24(15)33-2)30-35(32)10-3-11-35)27-14-28-25(23)29-19-9-4-16(26)12-22(19)34-18-7-5-17(31)6-8-18/h4,9,12-14,17-18,31H,3,5-8,10-11H2,1-2H3,(H,27,28,29)/t17-,18-
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Assay Description
The Z′-LYTEŽ biochemical assay employs a fluorescence-based, coupled-enzyme format and is based on the differential sensitivity of phosphorylat...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM313933
PNG
(US10167296, Example 2.44)
Show SMILES COc1c(C)c2c(Nc3ccc(F)cc3O[C@H]3CC[C@H](O)CC3)ncnc2cc1N=S1(=O)CCCC1
Show InChI InChI=1S/C26H31FN4O4S/c1-16-24-21(14-22(25(16)34-2)31-36(33)11-3-4-12-36)28-15-29-26(24)30-20-10-5-17(27)13-23(20)35-19-8-6-18(32)7-9-19/h5,10,13-15,18-19,32H,3-4,6-9,11-12H2,1-2H3,(H,28,29,30)/t18-,19-
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Assay Description
The Z′-LYTEŽ biochemical assay employs a fluorescence-based, coupled-enzyme format and is based on the differential sensitivity of phosphorylat...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM313904
PNG
(US10167296, Example 2.15)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(N=S3(=O)CCC3)c(OCCCN3CCOCC3)c(C)c12)C(F)(F)F
Show InChI InChI=1S/C28H33F4N5O4S/c1-18-25-22(33-17-34-27(25)35-21-6-5-20(29)15-24(21)41-19(2)28(30,31)32)16-23(36-42(38)13-4-14-42)26(18)40-10-3-7-37-8-11-39-12-9-37/h5-6,15-17,19H,3-4,7-14H2,1-2H3,(H,33,34,35)/t19-/m1/s1
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Assay Description
The Z′-LYTEŽ biochemical assay employs a fluorescence-based, coupled-enzyme format and is based on the differential sensitivity of phosphorylat...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM313939
PNG
(US10167296, Example 2.50)
Show SMILES COc1c(C)c2c(Nc3ccc(F)cc3O[C@H]3CCOC3)ncnc2cc1N=S(C)(C)=O
Show InChI InChI=1S/C22H25FN4O4S/c1-13-20-17(10-18(21(13)29-2)27-32(3,4)28)24-12-25-22(20)26-16-6-5-14(23)9-19(16)31-15-7-8-30-11-15/h5-6,9-10,12,15H,7-8,11H2,1-4H3,(H,24,25,26)/t15-/m0/s1
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Assay Description
The Z′-LYTEŽ biochemical assay employs a fluorescence-based, coupled-enzyme format and is based on the differential sensitivity of phosphorylat...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM313887
PNG
(US10167296, Example 1.02)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(N=S(C)(C)=O)c(OCCCN3CCCC3)c(C)c12)C(F)(F)F
Show InChI InChI=1S/C27H33F4N5O3S/c1-17-24-21(15-22(35-40(3,4)37)25(17)38-13-7-12-36-10-5-6-11-36)32-16-33-26(24)34-20-9-8-19(28)14-23(20)39-18(2)27(29,30)31/h8-9,14-16,18H,5-7,10-13H2,1-4H3,(H,32,33,34)/t18-/m1/s1
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Assay Description
The Z′-LYTEŽ biochemical assay employs a fluorescence-based, coupled-enzyme format and is based on the differential sensitivity of phosphorylat...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM313931
PNG
(US10167296, Example 2.42)
Show SMILES COc1c(C)c2c(Nc3ccc(F)cc3O[C@@H]3CO[C@@H]4CCO[C@H]34)ncnc2cc1N=S1(=O)CCC1
Show InChI InChI=1S/C25H27FN4O5S/c1-14-22-17(11-18(23(14)32-2)30-36(31)8-3-9-36)27-13-28-25(22)29-16-5-4-15(26)10-20(16)35-21-12-34-19-6-7-33-24(19)21/h4-5,10-11,13,19,21,24H,3,6-9,12H2,1-2H3,(H,27,28,29)/t19-,21-,24+/m1/s1
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Assay Description
The Z′-LYTEŽ biochemical assay employs a fluorescence-based, coupled-enzyme format and is based on the differential sensitivity of phosphorylat...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM313888
PNG
(US10167296, Example 1.03)
Show SMILES CCOc1c(C)c2c(Nc3ccc(F)cc3O[C@H](C)C(F)(F)F)ncnc2cc1N=S(C)(C)=O
Show InChI InChI=1S/C22H24F4N4O3S/c1-6-32-20-12(2)19-16(10-17(20)30-34(4,5)31)27-11-28-21(19)29-15-8-7-14(23)9-18(15)33-13(3)22(24,25)26/h7-11,13H,6H2,1-5H3,(H,27,28,29)/t13-/m1/s1
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Assay Description
The Z′-LYTEŽ biochemical assay employs a fluorescence-based, coupled-enzyme format and is based on the differential sensitivity of phosphorylat...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM313927
PNG
(US10167296, Example 2.38)
Show SMILES COc1c(C)c2c(Nc3ccc(F)cc3O[C@H]3COC[C@@H]3O)ncnc2cc1N=S(C)(C)=O
Show InChI InChI=1S/C22H25FN4O5S/c1-12-20-15(8-16(21(12)30-2)27-33(3,4)29)24-11-25-22(20)26-14-6-5-13(23)7-18(14)32-19-10-31-9-17(19)28/h5-8,11,17,19,28H,9-10H2,1-4H3,(H,24,25,26)/t17-,19-/m0/s1
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Assay Description
The Z′-LYTEŽ biochemical assay employs a fluorescence-based, coupled-enzyme format and is based on the differential sensitivity of phosphorylat...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM313900
PNG
(US10167296, Example 2.11)
Show SMILES COc1c(C)c2c(Nc3ccc(F)cc3O[C@H](C)C(=O)NCC(F)(F)F)ncnc2cc1N=S1(=O)CCC1
Show InChI InChI=1S/C24H25F4N5O4S/c1-13-20-17(10-18(21(13)36-3)33-38(35)7-4-8-38)30-12-31-22(20)32-16-6-5-15(25)9-19(16)37-14(2)23(34)29-11-24(26,27)28/h5-6,9-10,12,14H,4,7-8,11H2,1-3H3,(H,29,34)(H,30,31,32)/t14-/m1/s1
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Assay Description
The Z′-LYTEŽ biochemical assay employs a fluorescence-based, coupled-enzyme format and is based on the differential sensitivity of phosphorylat...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM313909
PNG
(US10167296, Example 2.20)
Show SMILES COc1c(cc2ncnc(Nc3cc4cn[nH]c4cc3OC(C)C)c2c1C)N=S(C)(C)=O
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Assay Description
The Z′-LYTEŽ biochemical assay employs a fluorescence-based, coupled-enzyme format and is based on the differential sensitivity of phosphorylat...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM313915
PNG
(US10167296, Example 2.26)
Show SMILES COc1c(C)c2c(Nc3ccc(F)cc3O[C@@H]3CO[C@@H]4[C@@H](F)CO[C@H]34)ncnc2cc1N=S1(=O)CCC1
Show InChI InChI=1S/C25H26F2N4O5S/c1-13-21-17(9-18(22(13)33-2)31-37(32)6-3-7-37)28-12-29-25(21)30-16-5-4-14(26)8-19(16)36-20-11-35-23-15(27)10-34-24(20)23/h4-5,8-9,12,15,20,23-24H,3,6-7,10-11H2,1-2H3,(H,28,29,30)/t15-,20+,23+,24+/m0/s1
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Assay Description
The Z′-LYTEŽ biochemical assay employs a fluorescence-based, coupled-enzyme format and is based on the differential sensitivity of phosphorylat...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM313921
PNG
(US10167296, Example 2.32)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(N=S(C)(C)=O)c(OCCN3CCN(C)C(=O)C3)c(C)c12)C(F)(F)F
Show InChI InChI=1S/C27H32F4N6O4S/c1-16-24-20(13-21(35-42(4,5)39)25(16)40-11-10-37-9-8-36(3)23(38)14-37)32-15-33-26(24)34-19-7-6-18(28)12-22(19)41-17(2)27(29,30)31/h6-7,12-13,15,17H,8-11,14H2,1-5H3,(H,32,33,34)/t17-/m1/s1
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Assay Description
The Z′-LYTEŽ biochemical assay employs a fluorescence-based, coupled-enzyme format and is based on the differential sensitivity of phosphorylat...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM313928
PNG
(US10167296, Example 2.39)
Show SMILES COc1c(C)c2c(Nc3ccc(Cl)cc3O[C@H](C)C(=O)NCC(F)(F)F)ncnc2cc1N=S1(=O)CCC1
Show InChI InChI=1S/C24H25ClF3N5O4S/c1-13-20-17(10-18(21(13)36-3)33-38(35)7-4-8-38)30-12-31-22(20)32-16-6-5-15(25)9-19(16)37-14(2)23(34)29-11-24(26,27)28/h5-6,9-10,12,14H,4,7-8,11H2,1-3H3,(H,29,34)(H,30,31,32)/t14-/m1/s1
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Assay Description
The Z′-LYTEŽ biochemical assay employs a fluorescence-based, coupled-enzyme format and is based on the differential sensitivity of phosphorylat...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM313924
PNG
(US10167296, Example 2.35)
Show SMILES COc1c(C)c2c(Nc3ccc(F)cc3O[C@H](C)C(F)(F)F)ncnc2cc1N=S1(=O)CCC1
Show InChI InChI=1S/C22H22F4N4O3S/c1-12-19-16(10-17(20(12)32-3)30-34(31)7-4-8-34)27-11-28-21(19)29-15-6-5-14(23)9-18(15)33-13(2)22(24,25)26/h5-6,9-11,13H,4,7-8H2,1-3H3,(H,27,28,29)/t13-/m1/s1
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Assay Description
The Z′-LYTEŽ biochemical assay employs a fluorescence-based, coupled-enzyme format and is based on the differential sensitivity of phosphorylat...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM313916
PNG
(US10167296, Example 2.27)
Show SMILES COc1c(C)c2c(Nc3cc4cn[nH]c4cc3OC(C)C)ncnc2cc1N=S1(=O)CCC1
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Assay Description
The Z′-LYTEŽ biochemical assay employs a fluorescence-based, coupled-enzyme format and is based on the differential sensitivity of phosphorylat...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM313950
PNG
(US10167296, Example 3.02)
Show SMILES COCCOc1c(C)c2c(Nc3ccc(F)cc3O[C@H](C)C(F)(F)F)ncnc2cc1N=S(C)(C)=O
Show InChI InChI=1S/C23H26F4N4O4S/c1-13-20-17(11-18(31-36(4,5)32)21(13)34-9-8-33-3)28-12-29-22(20)30-16-7-6-15(24)10-19(16)35-14(2)23(25,26)27/h6-7,10-12,14H,8-9H2,1-5H3,(H,28,29,30)/t14-/m1/s1
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Assay Description
The Z′-LYTEŽ biochemical assay employs a fluorescence-based, coupled-enzyme format and is based on the differential sensitivity of phosphorylat...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM313952
PNG
(US10167296, Example 3.04)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(N=S(C)(C)=O)c(OC3CCOC3)c(C)c12)C(F)(F)F
Show InChI InChI=1S/C24H26F4N4O4S/c1-13-21-18(10-19(32-37(3,4)33)22(13)36-16-7-8-34-11-16)29-12-30-23(21)31-17-6-5-15(25)9-20(17)35-14(2)24(26,27)28/h5-6,9-10,12,14,16H,7-8,11H2,1-4H3,(H,29,30,31)/t14-,16?/m1/s1
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Assay Description
The Z′-LYTEŽ biochemical assay employs a fluorescence-based, coupled-enzyme format and is based on the differential sensitivity of phosphorylat...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM313886
PNG
(US10167296, Example 1.01)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(N=S(C)(C)=O)c(OCCCN3CCN(C)C(=O)C3)c(C)c12)C(F)(F)F
Show InChI InChI=1S/C28H34F4N6O4S/c1-17-25-21(33-16-34-27(25)35-20-8-7-19(29)13-23(20)42-18(2)28(30,31)32)14-22(36-43(4,5)40)26(17)41-12-6-9-38-11-10-37(3)24(39)15-38/h7-8,13-14,16,18H,6,9-12,15H2,1-5H3,(H,33,34,35)/t18-/m1/s1
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Assay Description
The Z′-LYTEŽ biochemical assay employs a fluorescence-based, coupled-enzyme format and is based on the differential sensitivity of phosphorylat...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM313949
PNG
(US10167296, Example 3.01)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(N=S(C)(C)=O)c(OCC3CC3)c(C)c12)C(F)(F)F
Show InChI InChI=1S/C24H26F4N4O3S/c1-13-21-18(10-19(32-36(3,4)33)22(13)34-11-15-5-6-15)29-12-30-23(21)31-17-8-7-16(25)9-20(17)35-14(2)24(26,27)28/h7-10,12,14-15H,5-6,11H2,1-4H3,(H,29,30,31)/t14-/m1/s1
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Assay Description
The Z′-LYTEŽ biochemical assay employs a fluorescence-based, coupled-enzyme format and is based on the differential sensitivity of phosphorylat...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM313951
PNG
(US10167296, Example 3.03)
Show SMILES CC(C)Oc1c(C)c2c(Nc3ccc(F)cc3O[C@H](C)C(F)(F)F)ncnc2cc1N=S(C)(C)=O
Show InChI InChI=1S/C23H26F4N4O3S/c1-12(2)33-21-13(3)20-17(10-18(21)31-35(5,6)32)28-11-29-22(20)30-16-8-7-15(24)9-19(16)34-14(4)23(25,26)27/h7-12,14H,1-6H3,(H,28,29,30)/t14-/m1/s1
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Assay Description
The Z′-LYTEŽ biochemical assay employs a fluorescence-based, coupled-enzyme format and is based on the differential sensitivity of phosphorylat...


US Patent US10167296 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%