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Patent code US10172851

Compile Data Set for Download or QSAR

Found 1229 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
RET Kinase (aa658-end)


(Homo sapiens (human))
BDBM296817
PNG
(US10112942, Example 552 | US10137124, Example 552 ...)
Show SMILES COc1ccc(CN2C3CC2CN(C3)c2cnc(cn2)-c2cc(OC[C@H]3CNCCO3)cn3ncc(C#N)c23)cn1
Show InChI InChI=1S/C29H31N9O3/c1-39-28-3-2-19(9-34-28)14-37-21-6-22(37)16-36(15-21)27-13-32-26(12-33-27)25-7-23(41-18-24-11-31-4-5-40-24)17-38-29(25)20(8-30)10-35-38/h2-3,7,9-10,12-13,17,21-22,24,31H,4-6,11,14-16,18H2,1H3/t21?,22?,24-/m1/s1
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n/an/a 1n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...


US Patent US10172851 (2019)

More data for this
Ligand-Target Pair
RET Kinase (aa658-end)


(Homo sapiens (human))
BDBM296818
PNG
(US10112942, Example 553 | US10137124, Example 553 ...)
Show SMILES COc1ccc(CN2C3CC2CN(C3)c2cnc(cn2)-c2cc(OCC3(F)CNC3)cn3ncc(C#N)c23)cn1
Show InChI InChI=1S/C28H28FN9O2/c1-39-26-3-2-18(7-34-26)11-37-20-4-21(37)13-36(12-20)25-10-32-24(9-33-25)23-5-22(40-17-28(29)15-31-16-28)14-38-27(23)19(6-30)8-35-38/h2-3,5,7-10,14,20-21,31H,4,11-13,15-17H2,1H3
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n/an/a 2n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...


US Patent US10172851 (2019)

More data for this
Ligand-Target Pair
RET Kinase (aa658-end)


(Homo sapiens (human))
BDBM296816
PNG
(US10112942, Example 551 | US10137124, Example 551 ...)
Show SMILES COc1ccc(CN2C3CC2CN(C3)c2cnc(cn2)-c2cc(OC[C@@H]3CNCCO3)cn3ncc(C#N)c23)cn1
Show InChI InChI=1S/C29H31N9O3/c1-39-28-3-2-19(9-34-28)14-37-21-6-22(37)16-36(15-21)27-13-32-26(12-33-27)25-7-23(41-18-24-11-31-4-5-40-24)17-38-29(25)20(8-30)10-35-38/h2-3,7,9-10,12-13,17,21-22,24,31H,4-6,11,14-16,18H2,1H3/t21?,22?,24-/m0/s1
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n/an/a 3n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...


US Patent US10172851 (2019)

More data for this
Ligand-Target Pair
RET Kinase (aa658-end)


(Homo sapiens (human))
BDBM296809
PNG
(US10112942, Example 544 | US10137124, Example 544 ...)
Show SMILES CCOc1cc(-c2cnc(cn2)N2CC3CC(C2)N3Cc2cnc(OC)c(F)c2)c2c(cnn2c1)C#N
Show InChI InChI=1S/C26H25FN8O2/c1-3-37-20-6-21(25-17(7-28)9-32-35(25)15-20)23-10-30-24(11-29-23)33-13-18-5-19(14-33)34(18)12-16-4-22(27)26(36-2)31-8-16/h4,6,8-11,15,18-19H,3,5,12-14H2,1-2H3
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n/an/a 4n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...


US Patent US10172851 (2019)

More data for this
Ligand-Target Pair
RET Kinase (aa658-end)


(Homo sapiens (human))
BDBM296821
PNG
(US10112942, Example 556 | US10137124, Example 556 ...)
Show SMILES COc1cc(-c2cnc(cn2)N2CC3CC(C2)N3Cc2ccc(OC)nc2)c2c(Cl)cnn2c1
Show InChI InChI=1S/C24H24ClN7O2/c1-33-18-6-19(24-20(25)8-29-32(24)14-18)21-9-27-22(10-26-21)30-12-16-5-17(13-30)31(16)11-15-3-4-23(34-2)28-7-15/h3-4,6-10,14,16-17H,5,11-13H2,1-2H3
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n/an/a 4n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...


US Patent US10172851 (2019)

More data for this
Ligand-Target Pair
RET Kinase (aa658-end)


(Homo sapiens (human))
BDBM296696
PNG
(US10112942, Example 431 | US10137124, Example 431 ...)
Show SMILES COCCOc1cc(-c2ccc(nc2)N2CC3CC(C2)N3Cc2ccc(OC)nc2)c2c(cnn2c1)C#N
Show InChI InChI=1S/C28H29N7O3/c1-36-7-8-38-24-10-25(28-21(11-29)14-32-35(28)18-24)20-4-5-26(30-13-20)33-16-22-9-23(17-33)34(22)15-19-3-6-27(37-2)31-12-19/h3-6,10,12-14,18,22-23H,7-9,15-17H2,1-2H3
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n/an/a 4.5n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...


US Patent US10172851 (2019)

More data for this
Ligand-Target Pair
RET Kinase (aa658-end)


(Homo sapiens (human))
BDBM296733
PNG
(US10112942, Example 468 | US10137124, Example 468 ...)
Show SMILES COc1ccc(CN2C3CC2CN(C3)c2ccc(cn2)-c2cc(OCc3ncco3)cn3ncc(C#N)c23)cn1
Show InChI InChI=1S/C29H26N8O3/c1-38-27-5-2-19(11-33-27)14-36-22-8-23(36)16-35(15-22)26-4-3-20(12-32-26)25-9-24(40-18-28-31-6-7-39-28)17-37-29(25)21(10-30)13-34-37/h2-7,9,11-13,17,22-23H,8,14-16,18H2,1H3
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n/an/a 4.80n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...


US Patent US10172851 (2019)

More data for this
Ligand-Target Pair
RET Kinase (aa658-end)


(Homo sapiens (human))
BDBM296812
PNG
(6-ethoxy-4-(5-(6-(3- fluoro-4- methoxybenzyl)-3,6-...)
Show SMILES CCOc1cc(-c2cnc(cn2)N2CC3CC(C2)N3Cc2ccc(OC)c(F)c2)c2c(cnn2c1)C#N
Show InChI InChI=1S/C27H26FN7O2/c1-3-37-21-8-22(27-18(9-29)10-32-35(27)16-21)24-11-31-26(12-30-24)33-14-19-7-20(15-33)34(19)13-17-4-5-25(36-2)23(28)6-17/h4-6,8,10-12,16,19-20H,3,7,13-15H2,1-2H3
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n/an/a 5n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...


US Patent US10172851 (2019)

More data for this
Ligand-Target Pair
RET Kinase (aa658-end)


(Homo sapiens (human))
BDBM296735
PNG
(US10112942, Example 470 | US10137124, Example 470 ...)
Show SMILES COc1ccc(CN2C3CC2CN(C3)c2ccc(cn2)-c2cc(OCCn3ccnc3)cn3ncc(C#N)c23)cn1
Show InChI InChI=1S/C30H29N9O2/c1-40-29-5-2-21(13-34-29)16-38-24-10-25(38)18-37(17-24)28-4-3-22(14-33-28)27-11-26(41-9-8-36-7-6-32-20-36)19-39-30(27)23(12-31)15-35-39/h2-7,11,13-15,19-20,24-25H,8-10,16-18H2,1H3
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n/an/a 5.5n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...


US Patent US10172851 (2019)

More data for this
Ligand-Target Pair
RET Kinase (aa658-end)


(Homo sapiens (human))
BDBM296726
PNG
(US10112942, Example 461 | US10137124, Example 461 ...)
Show SMILES COc1ccc(CN2C3CC2CN(C3)c2ccc(cn2)-c2cc(OCCC3CNC3)cn3ncc(C#N)c23)cn1
Show InChI InChI=1S/C30H32N8O2/c1-39-29-5-2-21(13-34-29)16-37-24-8-25(37)18-36(17-24)28-4-3-22(14-33-28)27-9-26(40-7-6-20-11-32-12-20)19-38-30(27)23(10-31)15-35-38/h2-5,9,13-15,19-20,24-25,32H,6-8,11-12,16-18H2,1H3
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n/an/a 5.60n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...


US Patent US10172851 (2019)

More data for this
Ligand-Target Pair
RET Kinase (aa658-end)


(Homo sapiens (human))
BDBM296708
PNG
(US10112942, Example 443 | US10137124, Example 443 ...)
Show SMILES COCCN1CCC(COc2cc(-c3ccc(nc3)N3CC4CC(C3)N4Cc3ccc(OC)nc3)c3c(cnn3c2)C#N)CC1
Show InChI InChI=1S/C34H40N8O3/c1-43-12-11-39-9-7-24(8-10-39)23-45-30-14-31(34-27(15-35)18-38-42(34)22-30)26-4-5-32(36-17-26)40-20-28-13-29(21-40)41(28)19-25-3-6-33(44-2)37-16-25/h3-6,14,16-18,22,24,28-29H,7-13,19-21,23H2,1-2H3
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n/an/a 6.5n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...


US Patent US10172851 (2019)

More data for this
Ligand-Target Pair
RET Kinase (aa658-end)


(Homo sapiens (human))
BDBM296808
PNG
(US10112942, Example 543 | US10112942, Example 546 ...)
Show SMILES CCOc1cc(-c2cnc(cn2)N2CC3CC(C2)N3Cc2ccc(OC)nc2)c2c(cnn2c1)C#N
Show InChI InChI=1S/C26H26N8O2/c1-3-36-21-7-22(26-18(8-27)10-31-34(26)16-21)23-11-29-24(12-28-23)32-14-19-6-20(15-32)33(19)13-17-4-5-25(35-2)30-9-17/h4-5,7,9-12,16,19-20H,3,6,13-15H2,1-2H3
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n/an/a 7n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...


US Patent US10172851 (2019)

More data for this
Ligand-Target Pair
RET Kinase (V804M) (aa658-end)


(Homo sapiens (human))
BDBM296817
PNG
(US10112942, Example 552 | US10137124, Example 552 ...)
Show SMILES COc1ccc(CN2C3CC2CN(C3)c2cnc(cn2)-c2cc(OC[C@H]3CNCCO3)cn3ncc(C#N)c23)cn1
Show InChI InChI=1S/C29H31N9O3/c1-39-28-3-2-19(9-34-28)14-37-21-6-22(37)16-36(15-21)27-13-32-26(12-33-27)25-7-23(41-18-24-11-31-4-5-40-24)17-38-29(25)20(8-30)10-35-38/h2-3,7,9-10,12-13,17,21-22,24,31H,4-6,11,14-16,18H2,1H3/t21?,22?,24-/m1/s1
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...


US Patent US10172851 (2019)

More data for this
Ligand-Target Pair
RET Kinase (aa658-end)


(Homo sapiens (human))
BDBM296745
PNG
(US10112942, Example 480 | US10137124, Example 480 ...)
Show SMILES C[C@H](O)COc1cc(-c2ccc(nc2)N2CC3CC(C2)N3Cc2ccc(OC(F)F)nc2)c2c(cnn2c1)C#N
Show InChI InChI=1S/C28H27F2N7O3/c1-17(38)16-39-23-7-24(27-20(8-31)11-34-37(27)15-23)19-3-4-25(32-10-19)35-13-21-6-22(14-35)36(21)12-18-2-5-26(33-9-18)40-28(29)30/h2-5,7,9-11,15,17,21-22,28,38H,6,12-14,16H2,1H3/t17-,21?,22?/m0/s1
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n/an/a 7.40n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...


US Patent US10172851 (2019)

More data for this
Ligand-Target Pair
RET Kinase (aa658-end)


(Homo sapiens (human))
BDBM296709
PNG
(US10112942, Example 444 | US10137124, Example 444 ...)
Show SMILES COc1ccc(CN2C3CC2CN(C3)c2ccc(cn2)-c2cc(OCCC3CCN(C)CC3)cn3ncc(C#N)c23)cn1
Show InChI InChI=1S/C33H38N8O2/c1-38-10-7-23(8-11-38)9-12-43-29-14-30(33-26(15-34)18-37-41(33)22-29)25-4-5-31(35-17-25)39-20-27-13-28(21-39)40(27)19-24-3-6-32(42-2)36-16-24/h3-6,14,16-18,22-23,27-28H,7-13,19-21H2,1-2H3
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n/an/a 7.80n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...


US Patent US10172851 (2019)

More data for this
Ligand-Target Pair
RET Kinase (aa658-end)


(Homo sapiens (human))
BDBM315457
PNG
(US10172851, Example 110)
Show SMILES COc1ccc(CN2C3CC2CN(C3)c2ccc(cn2)-c2cc(OCCO)cn3ncc(C#N)c23)nc1
Show InChI InChI=1S/C27H27N7O3/c1-36-23-4-3-20(29-13-23)14-33-21-8-22(33)16-32(15-21)26-5-2-18(11-30-26)25-9-24(37-7-6-35)17-34-27(25)19(10-28)12-31-34/h2-5,9,11-13,17,21-22,35H,6-8,14-16H2,1H3
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n/an/a 8.10n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...


US Patent US10172851 (2019)

More data for this
Ligand-Target Pair
RET Kinase (aa658-end)


(Homo sapiens (human))
BDBM296710
PNG
(US10112942, Example 445 | US10137124, Example 445 ...)
Show SMILES COCCN1CCC(CCOc2cc(-c3ccc(nc3)N3CC4CC(C3)N4Cc3ccc(OC)nc3)c3c(cnn3c2)C#N)CC1
Show InChI InChI=1S/C35H42N8O3/c1-44-14-12-40-10-7-25(8-11-40)9-13-46-31-16-32(35-28(17-36)20-39-43(35)24-31)27-4-5-33(37-19-27)41-22-29-15-30(23-41)42(29)21-26-3-6-34(45-2)38-18-26/h3-6,16,18-20,24-25,29-30H,7-15,21-23H2,1-2H3
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n/an/a 8.20n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...


US Patent US10172851 (2019)

More data for this
Ligand-Target Pair
RET Kinase (aa658-end)


(Homo sapiens (human))
BDBM296716
PNG
(US10112942, Example 451 | US10137124, Example 451 ...)
Show SMILES COc1ccc(CN2C3CC2CN(C3)c2ccc(cn2)-c2cc(OCC3(F)CNC3)cn3ncc(C#N)c23)cn1
Show InChI InChI=1S/C29H29FN8O2/c1-39-27-5-2-19(9-34-27)12-37-22-6-23(37)14-36(13-22)26-4-3-20(10-33-26)25-7-24(40-18-29(30)16-32-17-29)15-38-28(25)21(8-31)11-35-38/h2-5,7,9-11,15,22-23,32H,6,12-14,16-18H2,1H3
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n/an/a 8.30n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...


US Patent US10172851 (2019)

More data for this
Ligand-Target Pair
RET Kinase (aa658-end)


(Homo sapiens (human))
BDBM296727
PNG
(US10112942, Example 462 | US10137124, Example 462 ...)
Show SMILES COc1ccc(CN2C3CC2CN(C3)c2ccc(cn2)-c2cc(OCCC3CN(C)C3)cn3ncc(C#N)c23)cn1
Show InChI InChI=1S/C31H34N8O2/c1-36-15-22(16-36)7-8-41-27-10-28(31-24(11-32)14-35-39(31)20-27)23-4-5-29(33-13-23)37-18-25-9-26(19-37)38(25)17-21-3-6-30(40-2)34-12-21/h3-6,10,12-14,20,22,25-26H,7-9,15-19H2,1-2H3
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n/an/a 9n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...


US Patent US10172851 (2019)

More data for this
Ligand-Target Pair
RET Kinase (aa658-end)


(Homo sapiens (human))
BDBM296747
PNG
(US10112942, Example 482 | US10137124, Example 482 ...)
Show SMILES COc1ccc(CN2C3CC2CN(C3)c2ccc(cn2)-c2cc(OC[C@H](O)CO)cn3ncc(C#N)c23)cn1
Show InChI InChI=1S/C28H29N7O4/c1-38-27-5-2-18(9-31-27)12-34-21-6-22(34)14-33(13-21)26-4-3-19(10-30-26)25-7-24(39-17-23(37)16-36)15-35-28(25)20(8-29)11-32-35/h2-5,7,9-11,15,21-23,36-37H,6,12-14,16-17H2,1H3/t21?,22?,23-/m1/s1
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n/an/a 9.10n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...


US Patent US10172851 (2019)

More data for this
Ligand-Target Pair
RET Kinase (aa658-end)


(Homo sapiens (human))
BDBM296718
PNG
(US10112942, Example 453 | US10137124, Example 453 ...)
Show SMILES COc1ccc(CN2C3CC2CN(C3)c2ccc(cn2)-c2cc(OCC3(C)CNC3)cn3ncc(C#N)c23)cn1
Show InChI InChI=1S/C30H32N8O2/c1-30(17-32-18-30)19-40-25-8-26(29-22(9-31)12-35-38(29)16-25)21-4-5-27(33-11-21)36-14-23-7-24(15-36)37(23)13-20-3-6-28(39-2)34-10-20/h3-6,8,10-12,16,23-24,32H,7,13-15,17-19H2,1-2H3
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n/an/a 9.20n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...


US Patent US10172851 (2019)

More data for this
Ligand-Target Pair
RET Kinase (aa658-end)


(Homo sapiens (human))
BDBM296699
PNG
(US10112942, Example 434 | US10137124, Example 434 ...)
Show SMILES COc1ccc(CN2C3CC2CN(C3)c2ccc(cn2)-c2cc(OC[C@@H]3CN(C)CCO3)cn3ncc(C#N)c23)cn1
Show InChI InChI=1S/C31H34N8O3/c1-36-7-8-41-27(18-36)20-42-26-10-28(31-23(11-32)14-35-39(31)19-26)22-4-5-29(33-13-22)37-16-24-9-25(17-37)38(24)15-21-3-6-30(40-2)34-12-21/h3-6,10,12-14,19,24-25,27H,7-9,15-18,20H2,1-2H3/t24?,25?,27-/m0/s1
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n/an/a 9.30n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...


US Patent US10172851 (2019)

More data for this
Ligand-Target Pair
RET Kinase (aa658-end)


(Homo sapiens (human))
BDBM296547
PNG
(6-(2-hydroxy-2- methylpropoxy)-4- (6-(6-(4- methox...)
Show SMILES COc1ccc(CN2C3CC2CN(C3)c2ccc(cn2)-c2cc(OCC(C)(C)O)cn3ncc(C#N)c23)cc1
Show InChI InChI=1S/C30H32N6O3/c1-30(2,37)19-39-26-11-27(29-22(12-31)14-33-36(29)18-26)21-6-9-28(32-13-21)34-16-23-10-24(17-34)35(23)15-20-4-7-25(38-3)8-5-20/h4-9,11,13-14,18,23-24,37H,10,15-17,19H2,1-3H3
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n/an/a 9.40n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...


US Patent US10172851 (2019)

More data for this
Ligand-Target Pair
RET Kinase (aa658-end)


(Homo sapiens (human))
BDBM296597
PNG
(4-(6-(6-(4- (difluoromethoxy) benzyl)-3,6- diazabi...)
Show SMILES CC(C)(O)COc1cc(-c2ccc(nc2)N2CC3CC(C2)N3Cc2ccc(OC(F)F)cc2)c2c(cnn2c1)C#N
Show InChI InChI=1S/C30H30F2N6O3/c1-30(2,39)18-40-25-10-26(28-21(11-33)13-35-38(28)17-25)20-5-8-27(34-12-20)36-15-22-9-23(16-36)37(22)14-19-3-6-24(7-4-19)41-29(31)32/h3-8,10,12-13,17,22-23,29,39H,9,14-16,18H2,1-2H3
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n/an/a 9.40n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...


US Patent US10172851 (2019)

More data for this
Ligand-Target Pair
RET Kinase (aa658-end)


(Homo sapiens (human))
BDBM296711
PNG
(US10112942, Example 446 | US10137124, Example 446 ...)
Show SMILES COc1ccc(CN2C3CC2CN(C3)c2ccc(cn2)-c2cc(OCCN3CCCC3)cn3ncc(C#N)c23)cn1
Show InChI InChI=1S/C31H34N8O2/c1-40-30-7-4-22(15-34-30)18-38-25-12-26(38)20-37(19-25)29-6-5-23(16-33-29)28-13-27(41-11-10-36-8-2-3-9-36)21-39-31(28)24(14-32)17-35-39/h4-7,13,15-17,21,25-26H,2-3,8-12,18-20H2,1H3
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n/an/a 9.5n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...


US Patent US10172851 (2019)

More data for this
Ligand-Target Pair
RET Kinase (aa658-end)


(Homo sapiens (human))
BDBM296700
PNG
(US10112942, Example 435 | US10137124, Example 435 ...)
Show SMILES COc1ccc(CN2C3CC2CN(C3)c2ccc(cn2)-c2cc(OC[C@@H]3CNC(C)(C)CO3)cn3ncc(C#N)c23)cn1
Show InChI InChI=1S/C32H36N8O3/c1-32(2)20-43-27(14-36-32)19-42-26-9-28(31-23(10-33)13-37-40(31)18-26)22-5-6-29(34-12-22)38-16-24-8-25(17-38)39(24)15-21-4-7-30(41-3)35-11-21/h4-7,9,11-13,18,24-25,27,36H,8,14-17,19-20H2,1-3H3/t24?,25?,27-/m0/s1
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n/an/a 9.5n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...


US Patent US10172851 (2019)

More data for this
Ligand-Target Pair
RET Kinase (aa658-end)


(Homo sapiens (human))
BDBM296205
PNG
(US10112942, Example 12 | US10137124, Example 12 | ...)
Show SMILES COCCOc1cc(-c2ccc(nc2)N2CCN(Cc3ccccc3)CC2)c2c(cnn2c1)C#N
Show InChI InChI=1S/C27H28N6O2/c1-34-13-14-35-24-15-25(27-23(16-28)18-30-33(27)20-24)22-7-8-26(29-17-22)32-11-9-31(10-12-32)19-21-5-3-2-4-6-21/h2-8,15,17-18,20H,9-14,19H2,1H3
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n/an/a 9.5n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...


US Patent US10172851 (2019)

More data for this
Ligand-Target Pair
RET Kinase (aa658-end)


(Homo sapiens (human))
BDBM296713
PNG
(US10112942, Example 448 | US10137124, Example 448 ...)
Show SMILES COc1ccc(CN2C3CC2CN(C3)c2ccc(cn2)-c2cc(OCC3CNC3)cn3ncc(C#N)c23)cn1
Show InChI InChI=1S/C29H30N8O2/c1-38-28-5-2-19(11-33-28)14-36-23-6-24(36)16-35(15-23)27-4-3-21(12-32-27)26-7-25(39-18-20-9-31-10-20)17-37-29(26)22(8-30)13-34-37/h2-5,7,11-13,17,20,23-24,31H,6,9-10,14-16,18H2,1H3
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n/an/a 9.60n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...


US Patent US10172851 (2019)

More data for this
Ligand-Target Pair
RET Kinase (aa658-end)


(Homo sapiens (human))
BDBM296581
PNG
(US10112942, Example 315 | US10137124, Example 315 ...)
Show SMILES COc1c(F)cc(CN2C3CC2CN(C3)c2ccc(cn2)-c2cc(OCC(C)(C)O)cn3ncc(C#N)c23)cc1F
Show InChI InChI=1S/C30H30F2N6O3/c1-30(2,39)17-41-23-9-24(28-20(10-33)12-35-38(28)16-23)19-4-5-27(34-11-19)36-14-21-8-22(15-36)37(21)13-18-6-25(31)29(40-3)26(32)7-18/h4-7,9,11-12,16,21-22,39H,8,13-15,17H2,1-3H3
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n/an/a 9.60n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...


US Patent US10172851 (2019)

More data for this
Ligand-Target Pair
RET Kinase (aa658-end)


(Homo sapiens (human))
BDBM296731
PNG
(US10112942, Example 466 | US10137124, Example 466 ...)
Show SMILES COc1ccc(CN2C3CC2CN(C3)c2ccc(cn2)-c2cc(OCc3cncn3C)cn3ncc(C#N)c23)cn1
Show InChI InChI=1S/C30H29N9O2/c1-36-19-32-13-25(36)18-41-26-8-27(30-22(9-31)12-35-39(30)17-26)21-4-5-28(33-11-21)37-15-23-7-24(16-37)38(23)14-20-3-6-29(40-2)34-10-20/h3-6,8,10-13,17,19,23-24H,7,14-16,18H2,1-2H3
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n/an/a 9.70n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...


US Patent US10172851 (2019)

More data for this
Ligand-Target Pair
RET Kinase (aa658-end)


(Homo sapiens (human))
BDBM296543
PNG
(US10112942, Example 277 | US10137124, Example 277 ...)
Show SMILES CC(C)(O)COc1cc(-c2ccc(nc2)N2CCN(CC2)C(=O)C(N)c2ccc(F)cc2)c2c(cnn2c1)C#N
Show InChI InChI=1S/C29H30FN7O3/c1-29(2,39)18-40-23-13-24(27-21(14-31)16-34-37(27)17-23)20-5-8-25(33-15-20)35-9-11-36(12-10-35)28(38)26(32)19-3-6-22(30)7-4-19/h3-8,13,15-17,26,39H,9-12,18,32H2,1-2H3
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n/an/a 9.70n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...


US Patent US10172851 (2019)

More data for this
Ligand-Target Pair
RET Kinase (aa658-end)


(Homo sapiens (human))
BDBM296226
PNG
(US10112942, Example 33 | US10137124, Example 33 | ...)
Show SMILES CCOc1cc(-c2ccc(nc2)N2CCN(CC2)C(=O)[C@H](O)c2ccc(F)cc2)c2c(cnn2c1)C#N
Show InChI InChI=1S/C27H25FN6O3/c1-2-37-22-13-23(25-20(14-29)16-31-34(25)17-22)19-5-8-24(30-15-19)32-9-11-33(12-10-32)27(36)26(35)18-3-6-21(28)7-4-18/h3-8,13,15-17,26,35H,2,9-12H2,1H3/t26-/m1/s1
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n/an/a 9.90n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...


US Patent US10172851 (2019)

More data for this
Ligand-Target Pair
RET Kinase (aa658-end)


(Homo sapiens (human))
BDBM296589
PNG
(US10112942, Example 323 | US10137124, Example 323 ...)
Show SMILES COc1ccc(CN2C3CC2CN(C3)c2ccc(cn2)-c2cc(OCC(C)(C)O)cn3ncc(C#N)c23)cc1F
Show InChI InChI=1S/C30H31FN6O3/c1-30(2,38)18-40-24-10-25(29-21(11-32)13-34-37(29)17-24)20-5-7-28(33-12-20)35-15-22-9-23(16-35)36(22)14-19-4-6-27(39-3)26(31)8-19/h4-8,10,12-13,17,22-23,38H,9,14-16,18H2,1-3H3
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n/an/a 9.90n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...


US Patent US10172851 (2019)

More data for this
Ligand-Target Pair
RET Kinase (aa658-end)


(Homo sapiens (human))
BDBM296772
PNG
(US10112942, Example 507 | US10137124, Example 507 ...)
Show SMILES CCOc1cc(-c2ccc(nc2)N2C[C@@H]3C[C@H]2CN3c2ccc(OC)nc2)c2c(cnn2c1)C#N
Show InChI InChI=1S/C26H25N7O2/c1-3-35-22-9-23(26-18(10-27)12-30-33(26)16-22)17-4-6-24(28-11-17)32-15-20-8-21(32)14-31(20)19-5-7-25(34-2)29-13-19/h4-7,9,11-13,16,20-21H,3,8,14-15H2,1-2H3/t20-,21-/m0/s1
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n/an/a 10n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...


US Patent US10172851 (2019)

More data for this
Ligand-Target Pair
RET Kinase (aa658-end)


(Homo sapiens (human))
BDBM296824
PNG
(6-ethoxy-4-(5-(6-((6- methoxy-5- methylpyridin-3- ...)
Show SMILES CCOc1cc(-c2cnc(cn2)N2CC3CC(C2)N3Cc2cnc(OC)c(C)c2)c2c(cnn2c1)C#N
Show InChI InChI=1S/C27H28N8O2/c1-4-37-22-7-23(26-19(8-28)10-32-35(26)16-22)24-11-30-25(12-29-24)33-14-20-6-21(15-33)34(20)13-18-5-17(2)27(36-3)31-9-18/h5,7,9-12,16,20-21H,4,6,13-15H2,1-3H3
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n/an/a 10n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...


US Patent US10172851 (2019)

More data for this
Ligand-Target Pair
RET Kinase (aa658-end)


(Homo sapiens (human))
BDBM296814
PNG
(US10112942, Example 549 | US10137124, Example 549 ...)
Show SMILES COc1ncc(CN2C3CC2CN(C3)c2cnc(cn2)-c2cc(OCCN3CCOCC3)cn3ncc(C#N)c23)cc1Cl
Show InChI InChI=1S/C30H32ClN9O3/c1-41-30-26(31)8-20(12-35-30)16-39-22-9-23(39)18-38(17-22)28-15-33-27(14-34-28)25-10-24(19-40-29(25)21(11-32)13-36-40)43-7-4-37-2-5-42-6-3-37/h8,10,12-15,19,22-23H,2-7,9,16-18H2,1H3
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n/an/a 10n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...


US Patent US10172851 (2019)

More data for this
Ligand-Target Pair
RET Kinase (aa658-end)


(Homo sapiens (human))
BDBM296546
PNG
(US10112942, Example 280 | US10137124, Example 280 ...)
Show SMILES CCc1ccc(CN2C3CC2CN(C3)c2ccc(cn2)-c2cc(OCC(C)(C)O)cn3ncc(C#N)c23)cn1
Show InChI InChI=1S/C30H33N7O2/c1-4-23-7-5-20(12-32-23)15-36-24-9-25(36)17-35(16-24)28-8-6-21(13-33-28)27-10-26(39-19-30(2,3)38)18-37-29(27)22(11-31)14-34-37/h5-8,10,12-14,18,24-25,38H,4,9,15-17,19H2,1-3H3
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n/an/a 10.2n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...


US Patent US10172851 (2019)

More data for this
Ligand-Target Pair
RET Kinase (aa658-end)


(Homo sapiens (human))
BDBM315476
PNG
(US10172851, Example 128)
Show SMILES COc1ccc(CN2C3CC2CN(C3)c2ccc(cn2)-c2cc(OC[C@@H](C)O)cn3ncc(C#N)c23)nc1
Show InChI InChI=1S/C28H29N7O3/c1-18(36)17-38-25-8-26(28-20(9-29)11-32-35(28)16-25)19-3-6-27(31-10-19)33-14-22-7-23(15-33)34(22)13-21-4-5-24(37-2)12-30-21/h3-6,8,10-12,16,18,22-23,36H,7,13-15,17H2,1-2H3/t18-,22?,23?/m1/s1
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n/an/a 10.2n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...


US Patent US10172851 (2019)

More data for this
Ligand-Target Pair
RET Kinase (V804M) (aa658-end)


(Homo sapiens (human))
BDBM296733
PNG
(US10112942, Example 468 | US10137124, Example 468 ...)
Show SMILES COc1ccc(CN2C3CC2CN(C3)c2ccc(cn2)-c2cc(OCc3ncco3)cn3ncc(C#N)c23)cn1
Show InChI InChI=1S/C29H26N8O3/c1-38-27-5-2-19(11-33-27)14-36-22-8-23(36)16-35(15-22)26-4-3-20(12-32-26)25-9-24(40-18-28-31-6-7-39-28)17-37-29(25)21(10-30)13-34-37/h2-7,9,11-13,17,22-23H,8,14-16,18H2,1H3
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n/an/a 10.2n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...


US Patent US10172851 (2019)

More data for this
Ligand-Target Pair
RET Kinase (V804M) (aa658-end)


(Homo sapiens (human))
BDBM296735
PNG
(US10112942, Example 470 | US10137124, Example 470 ...)
Show SMILES COc1ccc(CN2C3CC2CN(C3)c2ccc(cn2)-c2cc(OCCn3ccnc3)cn3ncc(C#N)c23)cn1
Show InChI InChI=1S/C30H29N9O2/c1-40-29-5-2-21(13-34-29)16-38-24-10-25(38)18-37(17-24)28-4-3-22(14-33-28)27-11-26(41-9-8-36-7-6-32-20-36)19-39-30(27)23(12-31)15-35-39/h2-7,11,13-15,19-20,24-25H,8-10,16-18H2,1H3
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n/an/a 10.4n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...


US Patent US10172851 (2019)

More data for this
Ligand-Target Pair
RET Kinase (aa658-end)


(Homo sapiens (human))
BDBM296703
PNG
(US10112942, Example 438 | US10137124, Example 438 ...)
Show SMILES COc1ncc(CN2C3CC2CN(C3)c2ccc(cn2)-c2cc(OCCN3CCOCC3)cn3ncc(C#N)c23)cc1Cl
Show InChI InChI=1S/C31H33ClN8O3/c1-41-31-28(32)10-21(14-35-31)17-39-24-11-25(39)19-38(18-24)29-3-2-22(15-34-29)27-12-26(20-40-30(27)23(13-33)16-36-40)43-9-6-37-4-7-42-8-5-37/h2-3,10,12,14-16,20,24-25H,4-9,11,17-19H2,1H3
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n/an/a 10.4n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...


US Patent US10172851 (2019)

More data for this
Ligand-Target Pair
RET Kinase (aa658-end)


(Homo sapiens (human))
BDBM296515
PNG
(US10112942, Example 249 | US10137124, Example 249 ...)
Show SMILES CC(C)(O)COc1cc(-c2ccc(nc2)N2CC3CC(C2)N3Cc2ccc3ncccc3c2)c2c(cnn2c1)C#N
Show InChI InChI=1S/C32H31N7O2/c1-32(2,40)20-41-27-12-28(31-24(13-33)15-36-39(31)19-27)23-6-8-30(35-14-23)37-17-25-11-26(18-37)38(25)16-21-5-7-29-22(10-21)4-3-9-34-29/h3-10,12,14-15,19,25-26,40H,11,16-18,20H2,1-2H3
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n/an/a 10.6n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...


US Patent US10172851 (2019)

More data for this
Ligand-Target Pair
RET Kinase (aa658-end)


(Homo sapiens (human))
BDBM315816
PNG
(US10172851, Example 459)
Show SMILES COc1ccc(CN2C3CC2CN(C3)c2ccc(cn2)-c2cc(OC3CC(O)C3)cn3ncc(C#N)c23)cn1
Show InChI InChI=1S/C29H29N7O3/c1-38-28-5-2-18(11-32-28)14-35-21-6-22(35)16-34(15-21)27-4-3-19(12-31-27)26-9-25(39-24-7-23(37)8-24)17-36-29(26)20(10-30)13-33-36/h2-5,9,11-13,17,21-24,37H,6-8,14-16H2,1H3
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n/an/a 10.6n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...


US Patent US10172851 (2019)

More data for this
Ligand-Target Pair
RET Kinase (V804M) (aa658-end)


(Homo sapiens (human))
BDBM296816
PNG
(US10112942, Example 551 | US10137124, Example 551 ...)
Show SMILES COc1ccc(CN2C3CC2CN(C3)c2cnc(cn2)-c2cc(OC[C@@H]3CNCCO3)cn3ncc(C#N)c23)cn1
Show InChI InChI=1S/C29H31N9O3/c1-39-28-3-2-19(9-34-28)14-37-21-6-22(37)16-36(15-21)27-13-32-26(12-33-27)25-7-23(41-18-24-11-31-4-5-40-24)17-38-29(25)20(8-30)10-35-38/h2-3,7,9-10,12-13,17,21-22,24,31H,4-6,11,14-16,18H2,1H3/t21?,22?,24-/m0/s1
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...


US Patent US10172851 (2019)

More data for this
Ligand-Target Pair
RET Kinase (V804M) (aa658-end)


(Homo sapiens (human))
BDBM296818
PNG
(US10112942, Example 553 | US10137124, Example 553 ...)
Show SMILES COc1ccc(CN2C3CC2CN(C3)c2cnc(cn2)-c2cc(OCC3(F)CNC3)cn3ncc(C#N)c23)cn1
Show InChI InChI=1S/C28H28FN9O2/c1-39-26-3-2-18(7-34-26)11-37-20-4-21(37)13-36(12-20)25-10-32-24(9-33-25)23-5-22(40-17-28(29)15-31-16-28)14-38-27(23)19(6-30)8-35-38/h2-3,5,7-10,14,20-21,31H,4,11-13,15-17H2,1H3
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...


US Patent US10172851 (2019)

More data for this
Ligand-Target Pair
RET Kinase (aa658-end)


(Homo sapiens (human))
BDBM296212
PNG
(US10112942, Example 19 | US10137124, Example 19 | ...)
Show SMILES CN1CC(CCOc2cc(-c3ccc(nc3)N3CCN(Cc4ccccc4)CC3)c3c(cnn3c2)C#N)C1
Show InChI InChI=1S/C30H33N7O/c1-34-19-24(20-34)9-14-38-27-15-28(30-26(16-31)18-33-37(30)22-27)25-7-8-29(32-17-25)36-12-10-35(11-13-36)21-23-5-3-2-4-6-23/h2-8,15,17-18,22,24H,9-14,19-21H2,1H3
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n/an/a 11.4n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...


US Patent US10172851 (2019)

More data for this
Ligand-Target Pair
RET Kinase (aa658-end)


(Homo sapiens (human))
BDBM296590
PNG
(4-(6-(6-(3-chloro- 4- methoxybenzyl)- 3,6- diazabi...)
Show SMILES COc1ccc(CN2C3CC2CN(C3)c2ccc(cn2)-c2cc(OCC(C)(C)O)cn3ncc(C#N)c23)cc1Cl
Show InChI InChI=1S/C30H31ClN6O3/c1-30(2,38)18-40-24-10-25(29-21(11-32)13-34-37(29)17-24)20-5-7-28(33-12-20)35-15-22-9-23(16-35)36(22)14-19-4-6-27(39-3)26(31)8-19/h4-8,10,12-13,17,22-23,38H,9,14-16,18H2,1-3H3
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n/an/a 11.4n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...


US Patent US10172851 (2019)

More data for this
Ligand-Target Pair
RET Kinase (aa658-end)


(Homo sapiens (human))
BDBM296715
PNG
(US10112942, Example 450 | US10137124, Example 450 ...)
Show SMILES COc1ccc(CN2C3CC2CN(C3)c2ccc(cn2)-c2cc(OCC3CN(C3)C(C)=O)cn3ncc(C#N)c23)cn1
Show InChI InChI=1S/C31H32N8O3/c1-20(40)36-13-22(14-36)19-42-27-8-28(31-24(9-32)12-35-39(31)18-27)23-4-5-29(33-11-23)37-16-25-7-26(17-37)38(25)15-21-3-6-30(41-2)34-10-21/h3-6,8,10-12,18,22,25-26H,7,13-17,19H2,1-2H3
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...


US Patent US10172851 (2019)

More data for this
Ligand-Target Pair
RET Kinase (aa658-end)


(Homo sapiens (human))
BDBM296211
PNG
(US10112942, Example 18 | US10137124, Example 18 | ...)
Show SMILES N#Cc1cnn2cc(OCC3COC3)cc(-c3ccc(nc3)N3CCN(Cc4ccccc4)CC3)c12
Show InChI InChI=1S/C28H28N6O2/c29-13-24-15-31-34-17-25(36-20-22-18-35-19-22)12-26(28(24)34)23-6-7-27(30-14-23)33-10-8-32(9-11-33)16-21-4-2-1-3-5-21/h1-7,12,14-15,17,22H,8-11,16,18-20H2
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...


US Patent US10172851 (2019)

More data for this
Ligand-Target Pair
RET Kinase (aa658-end)


(Homo sapiens (human))
BDBM296714
PNG
(US10112942, Example 449 | US10137124, Example 449 ...)
Show SMILES COc1ccc(CN2C3CC2CN(C3)c2ccc(cn2)-c2cc(OCC3CN(C)C3)cn3ncc(C#N)c23)cn1
Show InChI InChI=1S/C30H32N8O2/c1-35-13-21(14-35)19-40-26-8-27(30-23(9-31)12-34-38(30)18-26)22-4-5-28(32-11-22)36-16-24-7-25(17-36)37(24)15-20-3-6-29(39-2)33-10-20/h3-6,8,10-12,18,21,24-25H,7,13-17,19H2,1-2H3
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...


US Patent US10172851 (2019)

More data for this
Ligand-Target Pair
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