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Patent code US10172856

Compile Data Set for Download or QSAR
Found 122 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine H4 receptor


(Homo sapiens (human))
BDBM315434
PNG
(US10172856, Example 86)
Show SMILES CC(C)Oc1cc(Br)ccc1N(C(C)C)c1ccnc(N)n1
Show InChI InChI=1S/C16H21BrN4O/c1-10(2)21(15-7-8-19-16(18)20-15)13-6-5-12(17)9-14(13)22-11(3)4/h5-11H,1-4H3,(H2,18,19,20)
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3n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315466
PNG
(US10172856, Example 115)
Show SMILES CCCc1cc(ccc1N(C(C)C)c1ccnc(N)n1)C(F)(F)F
Show InChI InChI=1S/C17H21F3N4/c1-4-5-12-10-13(17(18,19)20)6-7-14(12)24(11(2)3)15-8-9-22-16(21)23-15/h6-11H,4-5H2,1-3H3,(H2,21,22,23)
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Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315348
PNG
(US10172856, Example 1)
Show SMILES CCOc1cc(F)ccc1N(C(C)C)c1ccnc(N)n1
Show InChI InChI=1S/C15H19FN4O/c1-4-21-13-9-11(16)5-6-12(13)20(10(2)3)14-7-8-18-15(17)19-14/h5-10H,4H2,1-3H3,(H2,17,18,19)
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6n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315377
PNG
(US10172856, Example 30)
Show SMILES CC(C)N(c1ccnc(N)n1)c1ccc(cc1C)S(F)(F)(F)(F)F
Show InChI InChI=1S/C14H17F5N4S/c1-9(2)23(13-6-7-21-14(20)22-13)12-5-4-11(8-10(12)3)24(15,16,17,18)19/h4-9H,1-3H3,(H2,20,21,22)
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Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315471
PNG
(US10172856, Example 119)
Show SMILES CCCc1cc(F)ccc1N(C(C)C)c1ccnc(N)n1
Show InChI InChI=1S/C16H21FN4/c1-4-5-12-10-13(17)6-7-14(12)21(11(2)3)15-8-9-19-16(18)20-15/h6-11H,4-5H2,1-3H3,(H2,18,19,20)
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Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315465
PNG
(US10172856, Example 114)
Show SMILES C\C=C\c1cc(ccc1N(C(C)C)c1ccnc(N)n1)C(F)(F)F
Show InChI InChI=1S/C17H19F3N4/c1-4-5-12-10-13(17(18,19)20)6-7-14(12)24(11(2)3)15-8-9-22-16(21)23-15/h4-11H,1-3H3,(H2,21,22,23)/b5-4+
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7n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315386
PNG
(US10172856, Example 38)
Show SMILES Cc1cc(ccc1N(Cc1cscn1)c1ccnc(N)n1)S(F)(F)(F)(F)F
Show InChI InChI=1S/C15H14F5N5S2/c1-10-6-12(27(16,17,18,19)20)2-3-13(10)25(7-11-8-26-9-23-11)14-4-5-22-15(21)24-14/h2-6,8-9H,7H2,1H3,(H2,21,22,24)
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7n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315370
PNG
(US10172856, Example 23)
Show SMILES CCc1cc(ccc1N(Cc1cocn1)c1ccnc(N)n1)S(F)(F)(F)(F)F
Show InChI InChI=1S/C16H16F5N5OS/c1-2-11-7-13(28(17,18,19,20)21)3-4-14(11)26(8-12-9-27-10-24-12)15-5-6-23-16(22)25-15/h3-7,9-10H,2,8H2,1H3,(H2,22,23,25)
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Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315391
PNG
(US10172856, Example 43)
Show SMILES CCN(c1ccnc(N)n1)c1ccc(cc1C1CCC1)S(=O)(=O)C(F)(F)F
Show InChI InChI=1S/C17H19F3N4O2S/c1-2-24(15-8-9-22-16(21)23-15)14-7-6-12(27(25,26)17(18,19)20)10-13(14)11-4-3-5-11/h6-11H,2-5H2,1H3,(H2,21,22,23)
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Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315433
PNG
(US10172856, Example 85)
Show SMILES CC(C)N(c1ccnc(N)n1)c1ccc(Br)cc1OC(F)(F)F
Show InChI InChI=1S/C14H14BrF3N4O/c1-8(2)22(12-5-6-20-13(19)21-12)10-4-3-9(15)7-11(10)23-14(16,17)18/h3-8H,1-2H3,(H2,19,20,21)
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Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315458
PNG
(US10172856, Example 109)
Show SMILES CCc1cc(ccc1N(Cc1cocn1)c1ccnc(N)n1)C(F)(F)F
Show InChI InChI=1S/C17H16F3N5O/c1-2-11-7-12(17(18,19)20)3-4-14(11)25(8-13-9-26-10-23-13)15-5-6-22-16(21)24-15/h3-7,9-10H,2,8H2,1H3,(H2,21,22,24)
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Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315381
PNG
(US10172856, Example 33)
Show SMILES Cc1ocnc1CN(c1ccnc(N)n1)c1ccc(cc1C)S(F)(F)(F)(F)F
Show InChI InChI=1S/C16H16F5N5OS/c1-10-7-12(28(17,18,19,20)21)3-4-14(10)26(8-13-11(2)27-9-24-13)15-5-6-23-16(22)25-15/h3-7,9H,8H2,1-2H3,(H2,22,23,25)
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9n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315353
PNG
(US10172856, Example 6)
Show SMILES Nc1nccc(n1)N(Cc1cocn1)c1ccc(OC(F)(F)F)cc1C1CCC1
Show InChI InChI=1S/C19H18F3N5O2/c20-19(21,22)29-14-4-5-16(15(8-14)12-2-1-3-12)27(9-13-10-28-11-25-13)17-6-7-24-18(23)26-17/h4-8,10-12H,1-3,9H2,(H2,23,24,26)
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Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315366
PNG
(US10172856, Example 19)
Show SMILES Cc1cc(ccc1N(Cc1cocn1)c1ccnc(N)n1)S(F)(F)(F)(F)F
Show InChI InChI=1S/C15H14F5N5OS/c1-10-6-12(27(16,17,18,19)20)2-3-13(10)25(7-11-8-26-9-23-11)14-4-5-22-15(21)24-14/h2-6,8-9H,7H2,1H3,(H2,21,22,24)
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Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315372
PNG
(US10172856, Example 25)
Show SMILES CCc1cc(ccc1N(Cc1ccn[nH]1)c1ccnc(N)n1)S(F)(F)(F)(F)F
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Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315399
PNG
(US10172856, Example 51)
Show SMILES CC(C)N(c1ccnc(N)n1)c1ccc(cc1C1CCC1)S(=O)(=O)C(F)(F)F
Show InChI InChI=1S/C18H21F3N4O2S/c1-11(2)25(16-8-9-23-17(22)24-16)15-7-6-13(28(26,27)18(19,20)21)10-14(15)12-4-3-5-12/h6-12H,3-5H2,1-2H3,(H2,22,23,24)
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Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315435
PNG
(US10172856, Example 87)
Show SMILES CC(C)N(c1ccnc(N)n1)c1ccc(Br)cc1OCC(F)(F)F
Show InChI InChI=1S/C15H16BrF3N4O/c1-9(2)23(13-5-6-21-14(20)22-13)11-4-3-10(16)7-12(11)24-8-15(17,18)19/h3-7,9H,8H2,1-2H3,(H2,20,21,22)
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Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315470
PNG
(US10172856, Example 118)
Show SMILES C\C=C\c1cc(F)ccc1N(C(C)C)c1ccnc(N)n1
Show InChI InChI=1S/C16H19FN4/c1-4-5-12-10-13(17)6-7-14(12)21(11(2)3)15-8-9-19-16(18)20-15/h4-11H,1-3H3,(H2,18,19,20)/b5-4+
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Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315355
PNG
(US10172856, Example 8)
Show SMILES CC(C)Cc1cc(OC(F)(F)F)ccc1N(Cc1cocn1)c1ccnc(N)n1
Show InChI InChI=1S/C19H20F3N5O2/c1-12(2)7-13-8-15(29-19(20,21)22)3-4-16(13)27(9-14-10-28-11-25-14)17-5-6-24-18(23)26-17/h3-6,8,10-12H,7,9H2,1-2H3,(H2,23,24,26)
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Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315351
PNG
(US10172856, Example 4)
Show SMILES CCOc1cc(F)ccc1N(Cc1ccccc1)c1ccnc(N)n1
Show InChI InChI=1S/C19H19FN4O/c1-2-25-17-12-15(20)8-9-16(17)24(13-14-6-4-3-5-7-14)18-10-11-22-19(21)23-18/h3-12H,2,13H2,1H3,(H2,21,22,23)
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Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315385
PNG
(US10172856, Example 37)
Show SMILES Cc1cc(ccc1N(Cc1ncccc1Cl)c1ccnc(N)n1)S(F)(F)(F)(F)F
Show InChI InChI=1S/C17H15ClF5N5S/c1-11-9-12(29(19,20,21,22)23)4-5-15(11)28(16-6-8-26-17(24)27-16)10-14-13(18)3-2-7-25-14/h2-9H,10H2,1H3,(H2,24,26,27)
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Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315392
PNG
(US10172856, Example 44)
Show SMILES Nc1nccc(n1)N(Cc1cocn1)c1ccc(cc1C1CCC1)S(=O)(=O)C(F)(F)F
Show InChI InChI=1S/C19H18F3N5O3S/c20-19(21,22)31(28,29)14-4-5-16(15(8-14)12-2-1-3-12)27(9-13-10-30-11-25-13)17-6-7-24-18(23)26-17/h4-8,10-12H,1-3,9H2,(H2,23,24,26)
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Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315382
PNG
(US10172856, Example 34)
Show SMILES Cc1cc(ccc1N(Cc1ccon1)c1ccnc(N)n1)S(F)(F)(F)(F)F
Show InChI InChI=1S/C15H14F5N5OS/c1-10-8-12(27(16,17,18,19)20)2-3-13(10)25(9-11-5-7-26-24-11)14-4-6-22-15(21)23-14/h2-8H,9H2,1H3,(H2,21,22,23)
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Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315387
PNG
(US10172856, Example 39)
Show SMILES Cc1cc(ccc1N(Cc1n[nH]cc1F)c1ccnc(N)n1)S(F)(F)(F)(F)F
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14n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315383
PNG
(US10172856, Example 35)
Show SMILES Cc1cc(ccc1N(Cc1cnco1)c1ccnc(N)n1)S(F)(F)(F)(F)F
Show InChI InChI=1S/C15H14F5N5OS/c1-10-6-12(27(16,17,18,19)20)2-3-13(10)25(8-11-7-22-9-26-11)14-4-5-23-15(21)24-14/h2-7,9H,8H2,1H3,(H2,21,23,24)
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Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315352
PNG
(US10172856, Example 5)
Show SMILES CCCc1cc(OC(F)(F)F)ccc1N(Cc1cocn1)c1ccnc(N)n1
Show InChI InChI=1S/C18H18F3N5O2/c1-2-3-12-8-14(28-18(19,20)21)4-5-15(12)26(9-13-10-27-11-24-13)16-6-7-23-17(22)25-16/h4-8,10-11H,2-3,9H2,1H3,(H2,22,23,25)
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Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315384
PNG
(US10172856, Example 36)
Show SMILES Cc1cc(ccc1N(Cc1ncco1)c1ccnc(N)n1)S(F)(F)(F)(F)F
Show InChI InChI=1S/C15H14F5N5OS/c1-10-8-11(27(16,17,18,19)20)2-3-12(10)25(9-14-22-6-7-26-14)13-4-5-23-15(21)24-13/h2-8H,9H2,1H3,(H2,21,23,24)
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Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315445
PNG
(US10172856, Example 97)
Show SMILES CCCc1cc(ccc1N(C(C)C)c1ccnc(N)n1)C#N
Show InChI InChI=1S/C17H21N5/c1-4-5-14-10-13(11-18)6-7-15(14)22(12(2)3)16-8-9-20-17(19)21-16/h6-10,12H,4-5H2,1-3H3,(H2,19,20,21)
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Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315388
PNG
(US10172856, Example 40)
Show SMILES Cc1cc(ccc1N(Cc1n[nH]cc1Cl)c1ccnc(N)n1)S(F)(F)(F)(F)F
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Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315401
PNG
(US10172856, Example 53)
Show SMILES CCc1cc(OC(F)(F)F)ccc1N(Cc1cocn1)c1ccnc(N)n1
Show InChI InChI=1S/C17H16F3N5O2/c1-2-11-7-13(27-17(18,19)20)3-4-14(11)25(8-12-9-26-10-23-12)15-5-6-22-16(21)24-15/h3-7,9-10H,2,8H2,1H3,(H2,21,22,24)
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Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315410
PNG
(US10172856, Example 62)
Show SMILES CC(C)Cc1cc(ccc1N(Cc1cocn1)c1ccnc(N)n1)S(=O)(=O)C(F)(F)F
Show InChI InChI=1S/C19H20F3N5O3S/c1-12(2)7-13-8-15(31(28,29)19(20,21)22)3-4-16(13)27(9-14-10-30-11-25-14)17-5-6-24-18(23)26-17/h3-6,8,10-12H,7,9H2,1-2H3,(H2,23,24,26)
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Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315389
PNG
(US10172856, Example 41)
Show SMILES Cc1cc(ccc1N(Cc1cc[nH]n1)c1ccnc(N)n1)S(F)(F)(F)(F)F
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Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315467
PNG
(US10172856, Example 116)
Show SMILES CC(C)N(c1ccnc(N)n1)c1ccc(cc1C)C(F)(F)F
Show InChI InChI=1S/C15H17F3N4/c1-9(2)22(13-6-7-20-14(19)21-13)12-5-4-11(8-10(12)3)15(16,17)18/h4-9H,1-3H3,(H2,19,20,21)
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Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315447
PNG
(US10172856, Example 99)
Show SMILES C\C=C\c1cc(ccc1N(C(C)C)c1ccnc(N)n1)C#N
Show InChI InChI=1S/C17H19N5/c1-4-5-14-10-13(11-18)6-7-15(14)22(12(2)3)16-8-9-20-17(19)21-16/h4-10,12H,1-3H3,(H2,19,20,21)/b5-4+
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Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315411
PNG
(US10172856, Example 63)
Show SMILES CCc1cc(ccc1N(C(C)C)c1ccnc(N)n1)S(=O)(=O)C(F)(F)F
Show InChI InChI=1S/C16H19F3N4O2S/c1-4-11-9-12(26(24,25)16(17,18)19)5-6-13(11)23(10(2)3)14-7-8-21-15(20)22-14/h5-10H,4H2,1-3H3,(H2,20,21,22)
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Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315473
PNG
(US10172856, Example 121)
Show SMILES CC(C)N(c1ccnc(N)n1)c1ccc(F)cc1C(C)C
Show InChI InChI=1S/C16H21FN4/c1-10(2)13-9-12(17)5-6-14(13)21(11(3)4)15-7-8-19-16(18)20-15/h5-11H,1-4H3,(H2,18,19,20)
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Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315380
PNG
(US10172856, Example 32)
Show SMILES Cc1cc(ccc1N(Cc1ncccn1)c1ccnc(N)n1)S(F)(F)(F)(F)F
Show InChI InChI=1S/C16H15F5N6S/c1-11-9-12(28(17,18,19,20)21)3-4-13(11)27(10-14-23-6-2-7-24-14)15-5-8-25-16(22)26-15/h2-9H,10H2,1H3,(H2,22,25,26)
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Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315420
PNG
(US10172856, Example 72)
Show SMILES CCCN(c1ccnc(N)n1)c1ccc(cc1CC(C)C)S(C)(=O)=O
Show InChI InChI=1S/C18H26N4O2S/c1-5-10-22(17-8-9-20-18(19)21-17)16-7-6-15(25(4,23)24)12-14(16)11-13(2)3/h6-9,12-13H,5,10-11H2,1-4H3,(H2,19,20,21)
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Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315459
PNG
(US10172856, Example 110)
Show SMILES Cc1cc(ccc1N(Cc1cocn1)c1ccnc(N)n1)C(F)(F)F
Show InChI InChI=1S/C16H14F3N5O/c1-10-6-11(16(17,18)19)2-3-13(10)24(7-12-8-25-9-22-12)14-4-5-21-15(20)23-14/h2-6,8-9H,7H2,1H3,(H2,20,21,23)
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Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315361
PNG
(US10172856, Example 14)
Show SMILES CCOc1cc(F)ccc1N(Cc1ccon1)c1ccnc(N)n1
Show InChI InChI=1S/C16H16FN5O2/c1-2-23-14-9-11(17)3-4-13(14)22(10-12-6-8-24-21-12)15-5-7-19-16(18)20-15/h3-9H,2,10H2,1H3,(H2,18,19,20)
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Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315360
PNG
(US10172856, Example 13)
Show SMILES CCOc1cc(F)ccc1N(Cc1n[nH]cc1Cl)c1ccnc(N)n1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315359
PNG
(US10172856, Example 12)
Show SMILES CCOc1cc(F)ccc1N(Cc1cocn1)c1ccnc(N)n1
Show InChI InChI=1S/C16H16FN5O2/c1-2-24-14-7-11(17)3-4-13(14)22(8-12-9-23-10-20-12)15-5-6-19-16(18)21-15/h3-7,9-10H,2,8H2,1H3,(H2,18,19,21)
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Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315454
PNG
(US10172856, Example 106)
Show SMILES CCN(c1ccnc(N)n1)c1ccc(cc1C1CCC1)S(=O)(=O)C1CC1
Show InChI InChI=1S/C19H24N4O2S/c1-2-23(18-10-11-21-19(20)22-18)17-9-8-15(26(24,25)14-6-7-14)12-16(17)13-4-3-5-13/h8-14H,2-7H2,1H3,(H2,20,21,22)
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Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315424
PNG
(US10172856, Example 76)
Show SMILES CCN(c1ccnc(N)n1)c1ccc(cc1CC)S(=O)(=O)C(F)F
Show InChI InChI=1S/C15H18F2N4O2S/c1-3-10-9-11(24(22,23)14(16)17)5-6-12(10)21(4-2)13-7-8-19-15(18)20-13/h5-9,14H,3-4H2,1-2H3,(H2,18,19,20)
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Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315369
PNG
(US10172856, Example 22)
Show SMILES CCN(c1ccnc(N)n1)c1ccc(cc1C)S(F)(F)(F)(F)F
Show InChI InChI=1S/C13H15F5N4S/c1-3-22(12-6-7-20-13(19)21-12)11-5-4-10(8-9(11)2)23(14,15,16,17)18/h4-8H,3H2,1-2H3,(H2,19,20,21)
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Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315363
PNG
(US10172856, Example 16)
Show SMILES CCOc1cc(F)ccc1N(Cc1cnco1)c1ccnc(N)n1
Show InChI InChI=1S/C16H16FN5O2/c1-2-23-14-7-11(17)3-4-13(14)22(9-12-8-19-10-24-12)15-5-6-20-16(18)21-15/h3-8,10H,2,9H2,1H3,(H2,18,20,21)
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Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315449
PNG
(US10172856, Example 101)
Show SMILES C\C=C\c1cc(Cl)ccc1N(Cc1cocn1)c1ccnc(N)n1
Show InChI InChI=1S/C17H16ClN5O/c1-2-3-12-8-13(18)4-5-15(12)23(9-14-10-24-11-21-14)16-6-7-20-17(19)22-16/h2-8,10-11H,9H2,1H3,(H2,19,20,22)/b3-2+
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Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315354
PNG
(US10172856, Example 7)
Show SMILES Cc1cc(OC(F)(F)F)ccc1N(Cc1cocn1)c1ccnc(N)n1
Show InChI InChI=1S/C16H14F3N5O2/c1-10-6-12(26-16(17,18)19)2-3-13(10)24(7-11-8-25-9-22-11)14-4-5-21-15(20)23-14/h2-6,8-9H,7H2,1H3,(H2,20,21,23)
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Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315412
PNG
(US10172856, Example 64)
Show SMILES CCc1cc(ccc1N(Cc1cocn1)c1ccnc(N)n1)S(=O)(=O)C(F)(F)F
Show InChI InChI=1S/C17H16F3N5O3S/c1-2-11-7-13(29(26,27)17(18,19)20)3-4-14(11)25(8-12-9-28-10-23-12)15-5-6-22-16(21)24-15/h3-7,9-10H,2,8H2,1H3,(H2,21,22,24)
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Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315364
PNG
(US10172856, Example 17)
Show SMILES CCOc1cc(F)ccc1N(Cc1cscn1)c1ccnc(N)n1
Show InChI InChI=1S/C16H16FN5OS/c1-2-23-14-7-11(17)3-4-13(14)22(8-12-9-24-10-20-12)15-5-6-19-16(18)21-15/h3-7,9-10H,2,8H2,1H3,(H2,18,19,21)
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29n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315400
PNG
(US10172856, Example 52)
Show SMILES CC(C)N(c1ccnc(N)n1)c1ccc(OC(F)(F)F)cc1C
Show InChI InChI=1S/C15H17F3N4O/c1-9(2)22(13-6-7-20-14(19)21-13)12-5-4-11(8-10(12)3)23-15(16,17)18/h4-9H,1-3H3,(H2,19,20,21)
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30n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315375
PNG
(US10172856, Example 28)
Show SMILES CC(C)N(c1ccnc(N)n1)c1ccc(cc1C1CCC1)S(=O)(=O)N1CCCC1
Show InChI InChI=1S/C21H29N5O2S/c1-15(2)26(20-10-11-23-21(22)24-20)19-9-8-17(14-18(19)16-6-5-7-16)29(27,28)25-12-3-4-13-25/h8-11,14-16H,3-7,12-13H2,1-2H3,(H2,22,23,24)
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30n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315367
PNG
(US10172856, Example 20)
Show SMILES CC(C)N(c1ccnc(N)n1)c1ccc(Br)cc1C(F)(F)F
Show InChI InChI=1S/C14H14BrF3N4/c1-8(2)22(12-5-6-20-13(19)21-12)11-4-3-9(15)7-10(11)14(16,17)18/h3-8H,1-2H3,(H2,19,20,21)
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30n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315450
PNG
(US10172856, Example 102)
Show SMILES CC(C)N(c1ccnc(N)n1)c1ccc(cc1C1CCC1)S(=O)(=O)C(C)C
Show InChI InChI=1S/C20H28N4O2S/c1-13(2)24(19-10-11-22-20(21)23-19)18-9-8-16(27(25,26)14(3)4)12-17(18)15-6-5-7-15/h8-15H,5-7H2,1-4H3,(H2,21,22,23)
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30n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315429
PNG
(US10172856, Example 81)
Show SMILES CCCN(C)S(=O)(=O)c1ccc(N(CCC)c2ccnc(N)n2)c(c1)C1CCC1
Show InChI InChI=1S/C21H31N5O2S/c1-4-13-25(3)29(27,28)17-9-10-19(18(15-17)16-7-6-8-16)26(14-5-2)20-11-12-23-21(22)24-20/h9-12,15-16H,4-8,13-14H2,1-3H3,(H2,22,23,24)
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31n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315358
PNG
(US10172856, Example 11)
Show SMILES CCOc1cc(F)ccc1N(Cc1cc[nH]n1)c1ccnc(N)n1
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31n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315356
PNG
(US10172856, Example 9)
Show SMILES CCc1cc(ccc1N(Cc1cocn1)c1ccnc(N)n1)C(O)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C19H17F6N5O2/c1-2-11-7-12(17(31,18(20,21)22)19(23,24)25)3-4-14(11)30(8-13-9-32-10-28-13)15-5-6-27-16(26)29-15/h3-7,9-10,31H,2,8H2,1H3,(H2,26,27,29)
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31n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315455
PNG
(US10172856, Example 107)
Show SMILES CCCN(c1ccnc(N)n1)c1ccc(cc1C1CCC1)S(=O)(=O)C1CC1
Show InChI InChI=1S/C20H26N4O2S/c1-2-12-24(19-10-11-22-20(21)23-19)18-9-8-16(27(25,26)15-6-7-15)13-17(18)14-4-3-5-14/h8-11,13-15H,2-7,12H2,1H3,(H2,21,22,23)
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32n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315402
PNG
(US10172856, Example 54)
Show SMILES CCCN(c1ccnc(N)n1)c1ccc(cc1C1CCC1)S(C)(=O)=O
Show InChI InChI=1S/C18H24N4O2S/c1-3-11-22(17-9-10-20-18(19)21-17)16-8-7-14(25(2,23)24)12-15(16)13-5-4-6-13/h7-10,12-13H,3-6,11H2,1-2H3,(H2,19,20,21)
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32n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315425
PNG
(US10172856, Example 77)
Show SMILES CCN(c1ccnc(N)n1)c1ccc(cc1C1CCC1)S(=O)(=O)CC
Show InChI InChI=1S/C18H24N4O2S/c1-3-22(17-10-11-20-18(19)21-17)16-9-8-14(25(23,24)4-2)12-15(16)13-6-5-7-13/h8-13H,3-7H2,1-2H3,(H2,19,20,21)
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34n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315439
PNG
(US10172856, Example 91)
Show SMILES Cc1cc(Br)ccc1N(Cc1cocn1)c1ccnc(N)n1
Show InChI InChI=1S/C15H14BrN5O/c1-10-6-11(16)2-3-13(10)21(7-12-8-22-9-19-12)14-4-5-18-15(17)20-14/h2-6,8-9H,7H2,1H3,(H2,17,18,20)
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34n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315436
PNG
(US10172856, Example 88)
Show SMILES CC(C)N(c1ccnc(N)n1)c1ccc(Br)cc1C
Show InChI InChI=1S/C14H17BrN4/c1-9(2)19(13-6-7-17-14(16)18-13)12-5-4-11(15)8-10(12)3/h4-9H,1-3H3,(H2,16,17,18)
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35n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315393
PNG
(US10172856, Example 45)
Show SMILES CC(C)N(c1ccnc(N)n1)c1ccc(cc1C1CCC1)S(C)(=O)=O
Show InChI InChI=1S/C18H24N4O2S/c1-12(2)22(17-9-10-20-18(19)21-17)16-8-7-14(25(3,23)24)11-15(16)13-5-4-6-13/h7-13H,4-6H2,1-3H3,(H2,19,20,21)
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35n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315379
PNG
(US10172856, Example 31)
Show SMILES COCCN(c1ccnc(N)n1)c1ccc(cc1C)S(F)(F)(F)(F)F
Show InChI InChI=1S/C14H17F5N4OS/c1-10-9-11(25(15,16,17,18)19)3-4-12(10)23(7-8-24-2)13-5-6-21-14(20)22-13/h3-6,9H,7-8H2,1-2H3,(H2,20,21,22)
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37n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315396
PNG
(US10172856, Example 48)
Show SMILES CS(=O)(=O)c1ccc(N(Cc2cccc(n2)C(F)(F)F)c2ccnc(N)n2)c(c1)C1CCC1
Show InChI InChI=1S/C22H22F3N5O2S/c1-33(31,32)16-8-9-18(17(12-16)14-4-2-5-14)30(20-10-11-27-21(26)29-20)13-15-6-3-7-19(28-15)22(23,24)25/h3,6-12,14H,2,4-5,13H2,1H3,(H2,26,27,29)
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37n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315394
PNG
(US10172856, Example 46)
Show SMILES CCc1cc(ccc1N(Cc1ncco1)c1ccnc(N)n1)S(=O)(=O)C(F)(F)F
Show InChI InChI=1S/C17H16F3N5O3S/c1-2-11-9-12(29(26,27)17(18,19)20)3-4-13(11)25(10-15-22-7-8-28-15)14-5-6-23-16(21)24-14/h3-9H,2,10H2,1H3,(H2,21,23,24)
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38n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315395
PNG
(US10172856, Example 47)
Show SMILES CCc1cc(ccc1N(Cc1ccncc1F)c1ccnc(N)n1)S(=O)(=O)C(F)(F)F
Show InChI InChI=1S/C19H17F4N5O2S/c1-2-12-9-14(31(29,30)19(21,22)23)3-4-16(12)28(17-6-8-26-18(24)27-17)11-13-5-7-25-10-15(13)20/h3-10H,2,11H2,1H3,(H2,24,26,27)
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39n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315368
PNG
(US10172856, Example 21)
Show SMILES CCN(c1ccnc(N)n1)c1ccc(cc1C1CCC1)S(C)(=O)=O
Show InChI InChI=1S/C17H22N4O2S/c1-3-21(16-9-10-19-17(18)20-16)15-8-7-13(24(2,22)23)11-14(15)12-5-4-6-12/h7-12H,3-6H2,1-2H3,(H2,18,19,20)
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39n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315472
PNG
(US10172856, Example 120)
Show SMILES CC(C)N(c1ccnc(N)n1)c1ccc(F)cc1C(C)=C
Show InChI InChI=1S/C16H19FN4/c1-10(2)13-9-12(17)5-6-14(13)21(11(3)4)15-7-8-19-16(18)20-15/h5-9,11H,1H2,2-4H3,(H2,18,19,20)
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40n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315430
PNG
(US10172856, Example 82)
Show SMILES Nc1nccc(n1)N(Cc1cocn1)c1ccc(Br)cc1OC(F)(F)F
Show InChI InChI=1S/C15H11BrF3N5O2/c16-9-1-2-11(12(5-9)26-15(17,18)19)24(6-10-7-25-8-22-10)13-3-4-21-14(20)23-13/h1-5,7-8H,6H2,(H2,20,21,23)
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41n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315406
PNG
(US10172856, Example 58)
Show SMILES CCN(c1ccnc(N)n1)c1ccc(cc1CC(C)C)S(C)(=O)=O
Show InChI InChI=1S/C17H24N4O2S/c1-5-21(16-8-9-19-17(18)20-16)15-7-6-14(24(4,22)23)11-13(15)10-12(2)3/h6-9,11-12H,5,10H2,1-4H3,(H2,18,19,20)
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42n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315404
PNG
(N4-(2-Cyclopropyl-4-(methylsulfonyl)phenyl)-N4-pro...)
Show SMILES CCCN(c1ccnc(N)n1)c1ccc(cc1C1CC1)S(C)(=O)=O
Show InChI InChI=1S/C17H22N4O2S/c1-3-10-21(16-8-9-19-17(18)20-16)15-7-6-13(24(2,22)23)11-14(15)12-4-5-12/h6-9,11-12H,3-5,10H2,1-2H3,(H2,18,19,20)
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44n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315462
PNG
(US10172856, Example 113)
Show SMILES CCN(c1ccnc(N)n1)c1ccc(cc1CC(C)C)C(N)=O
Show InChI InChI=1S/C17H23N5O/c1-4-22(15-7-8-20-17(19)21-15)14-6-5-12(16(18)23)10-13(14)9-11(2)3/h5-8,10-11H,4,9H2,1-3H3,(H2,18,23)(H2,19,20,21)
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45n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315373
PNG
(US10172856, Example 26)
Show SMILES CCc1cc(ccc1N(Cc1nnco1)c1ccnc(N)n1)S(F)(F)(F)(F)F
Show InChI InChI=1S/C15H15F5N6OS/c1-2-10-7-11(28(16,17,18,19)20)3-4-12(10)26(8-14-25-23-9-27-14)13-5-6-22-15(21)24-13/h3-7,9H,2,8H2,1H3,(H2,21,22,24)
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46n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315374
PNG
(US10172856, Example 27)
Show SMILES CC(C)N(c1ccnc(N)n1)c1ccc(cc1C=C(C)C)S(=O)(=O)N1CCCC1
Show InChI InChI=1S/C21H29N5O2S/c1-15(2)13-17-14-18(29(27,28)25-11-5-6-12-25)7-8-19(17)26(16(3)4)20-9-10-23-21(22)24-20/h7-10,13-14,16H,5-6,11-12H2,1-4H3,(H2,22,23,24)
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46n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315397
PNG
(US10172856, Example 49)
Show SMILES CCc1cc(ccc1N(Cc1c(C)noc1C)c1ccnc(N)n1)S(=O)(=O)C(F)(F)F
Show InChI InChI=1S/C19H20F3N5O3S/c1-4-13-9-14(31(28,29)19(20,21)22)5-6-16(13)27(17-7-8-24-18(23)25-17)10-15-11(2)26-30-12(15)3/h5-9H,4,10H2,1-3H3,(H2,23,24,25)
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53n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315357
PNG
(US10172856, Example 10)
Show SMILES CCOc1cc(F)ccc1N(Cc1ncco1)c1ccnc(N)n1
Show InChI InChI=1S/C16H16FN5O2/c1-2-23-13-9-11(17)3-4-12(13)22(10-15-19-7-8-24-15)14-5-6-20-16(18)21-14/h3-9H,2,10H2,1H3,(H2,18,20,21)
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54n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315460
PNG
(US10172856, Example 111)
Show SMILES CCN(c1ccnc(N)n1)c1ccc(cc1C1CCC1)C(N)=O
Show InChI InChI=1S/C17H21N5O/c1-2-22(15-8-9-20-17(19)21-15)14-7-6-12(16(18)23)10-13(14)11-4-3-5-11/h6-11H,2-5H2,1H3,(H2,18,23)(H2,19,20,21)
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59n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315453
PNG
(US10172856, Example 105)
Show SMILES CCCc1cc(ccc1N(CC)c1ccnc(N)n1)S(C)(=O)=O
Show InChI InChI=1S/C16H22N4O2S/c1-4-6-12-11-13(23(3,21)22)7-8-14(12)20(5-2)15-9-10-18-16(17)19-15/h7-11H,4-6H2,1-3H3,(H2,17,18,19)
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60n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315403
PNG
(US10172856, Example 55)
Show SMILES CCN(c1ccnc(N)n1)c1ccc(cc1C1CC1)S(C)(=O)=O
Show InChI InChI=1S/C16H20N4O2S/c1-3-20(15-8-9-18-16(17)19-15)14-7-6-12(23(2,21)22)10-13(14)11-4-5-11/h6-11H,3-5H2,1-2H3,(H2,17,18,19)
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60n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315365
PNG
(US10172856, Example 18)
Show SMILES Nc1nccc(n1)N(Cc1cc[nH]n1)c1ccc(F)cc1OCC(F)(F)F
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62n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315428
PNG
(US10172856, Example 80)
Show SMILES CCN(C)S(=O)(=O)c1ccc(N(CC)c2ccnc(N)n2)c(c1)C1CCC1
Show InChI InChI=1S/C19H27N5O2S/c1-4-23(3)27(25,26)15-9-10-17(16(13-15)14-7-6-8-14)24(5-2)18-11-12-21-19(20)22-18/h9-14H,4-8H2,1-3H3,(H2,20,21,22)
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65n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315390
PNG
(US10172856, Example 42)
Show SMILES CCN(c1ccnc(N)n1)c1ccc(cc1CC)S(=O)(=O)C(F)(F)F
Show InChI InChI=1S/C15H17F3N4O2S/c1-3-10-9-11(25(23,24)15(16,17)18)5-6-12(10)22(4-2)13-7-8-20-14(19)21-13/h5-9H,3-4H2,1-2H3,(H2,19,20,21)
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65n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315448
PNG
(US10172856, Example 100)
Show SMILES C\C=C\c1cc(ccc1N(C(C)C)c1ccnc(N)n1)C(N)=O
Show InChI InChI=1S/C17H21N5O/c1-4-5-12-10-13(16(18)23)6-7-14(12)22(11(2)3)15-8-9-20-17(19)21-15/h4-11H,1-3H3,(H2,18,23)(H2,19,20,21)/b5-4+
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66n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315461
PNG
(US10172856, Example 112)
Show SMILES CC(C)N(c1ccnc(N)n1)c1ccc(cc1C1CCC1)C(N)=O
Show InChI InChI=1S/C18H23N5O/c1-11(2)23(16-8-9-21-18(20)22-16)15-7-6-13(17(19)24)10-14(15)12-4-3-5-12/h6-12H,3-5H2,1-2H3,(H2,19,24)(H2,20,21,22)
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69n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315376
PNG
(US10172856, Example 29)
Show SMILES CCc1cc(ccc1N(Cc1cocn1)c1ccnc(N)n1)S(=O)(=O)C(F)F
Show InChI InChI=1S/C17H17F2N5O3S/c1-2-11-7-13(28(25,26)16(18)19)3-4-14(11)24(8-12-9-27-10-22-12)15-5-6-21-17(20)23-15/h3-7,9-10,16H,2,8H2,1H3,(H2,20,21,23)
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71n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315419
PNG
(US10172856, Example 71)
Show SMILES CCc1cc(ccc1N(C(C)C)c1ccnc(N)n1)S(C)(=O)=O
Show InChI InChI=1S/C16H22N4O2S/c1-5-12-10-13(23(4,21)22)6-7-14(12)20(11(2)3)15-8-9-18-16(17)19-15/h6-11H,5H2,1-4H3,(H2,17,18,19)
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71n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315362
PNG
(US10172856, Example 15)
Show SMILES CCOc1cc(F)ccc1N(Cc1cncs1)c1ccnc(N)n1
Show InChI InChI=1S/C16H16FN5OS/c1-2-23-14-7-11(17)3-4-13(14)22(9-12-8-19-10-24-12)15-5-6-20-16(18)21-15/h3-8,10H,2,9H2,1H3,(H2,18,20,21)
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75n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315398
PNG
(US10172856, Example 50)
Show SMILES CCc1cc(ccc1N(Cc1ncccn1)c1ccnc(N)n1)S(=O)(=O)C(F)(F)F
Show InChI InChI=1S/C18H17F3N6O2S/c1-2-12-10-13(30(28,29)18(19,20)21)4-5-14(12)27(11-15-23-7-3-8-24-15)16-6-9-25-17(22)26-16/h3-10H,2,11H2,1H3,(H2,22,25,26)
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81n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315432
PNG
(US10172856, Example 84)
Show SMILES CCN(c1ccnc(N)n1)c1ccc(cc1C(C)C)S(C)(=O)=O
Show InChI InChI=1S/C16H22N4O2S/c1-5-20(15-8-9-18-16(17)19-15)14-7-6-12(23(4,21)22)10-13(14)11(2)3/h6-11H,5H2,1-4H3,(H2,17,18,19)
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84n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315437
PNG
(US10172856, Example 89)
Show SMILES CC(C)N(c1ccnc(N)n1)c1ccc(cc1OC(F)(F)F)C#N
Show InChI InChI=1S/C15H14F3N5O/c1-9(2)23(13-5-6-21-14(20)22-13)11-4-3-10(8-19)7-12(11)24-15(16,17)18/h3-7,9H,1-2H3,(H2,20,21,22)
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91n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315423
PNG
(US10172856, Example 75)
Show SMILES CCc1cc(ccc1N(CCOC)c1ccnc(N)n1)S(=O)(=O)C(F)(F)F
Show InChI InChI=1S/C16H19F3N4O3S/c1-3-11-10-12(27(24,25)16(17,18)19)4-5-13(11)23(8-9-26-2)14-6-7-21-15(20)22-14/h4-7,10H,3,8-9H2,1-2H3,(H2,20,21,22)
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96n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315468
PNG
(US10172856, Example 117)
Show SMILES CCCc1cc(ccc1N(Cc1cocn1)c1ccnc(N)n1)C#N
Show InChI InChI=1S/C18H18N6O/c1-2-3-14-8-13(9-19)4-5-16(14)24(10-15-11-25-12-22-15)17-6-7-21-18(20)23-17/h4-8,11-12H,2-3,10H2,1H3,(H2,20,21,23)
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99n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315421
PNG
(US10172856, Example 73)
Show SMILES CCc1cc(ccc1N(Cc1cccc(n1)C(F)(F)F)c1ccnc(N)n1)S(=O)(=O)C(F)(F)F
Show InChI InChI=1S/C20H17F6N5O2S/c1-2-12-10-14(34(32,33)20(24,25)26)6-7-15(12)31(17-8-9-28-18(27)30-17)11-13-4-3-5-16(29-13)19(21,22)23/h3-10H,2,11H2,1H3,(H2,27,28,30)
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101n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315438
PNG
(US10172856, Example 90)
Show SMILES CCS(=O)(=O)c1ccc(N(C(C)C)c2ccnc(N)n2)c(OC(F)(F)F)c1
Show InChI InChI=1S/C16H19F3N4O3S/c1-4-27(24,25)11-5-6-12(13(9-11)26-16(17,18)19)23(10(2)3)14-7-8-21-15(20)22-14/h5-10H,4H2,1-3H3,(H2,20,21,22)
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111n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315431
PNG
(US10172856, Example 83)
Show SMILES CCN(c1ccnc(N)n1)c1ccc(cc1C(C)=C)S(C)(=O)=O
Show InChI InChI=1S/C16H20N4O2S/c1-5-20(15-8-9-18-16(17)19-15)14-7-6-12(23(4,21)22)10-13(14)11(2)3/h6-10H,2,5H2,1,3-4H3,(H2,17,18,19)
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120n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315408
PNG
(US10172856, Example 60)
Show SMILES COCCN(c1ccnc(N)n1)c1ccc(cc1C1CCC1)S(C)(=O)=O
Show InChI InChI=1S/C18H24N4O3S/c1-25-11-10-22(17-8-9-20-18(19)21-17)16-7-6-14(26(2,23)24)12-15(16)13-4-3-5-13/h6-9,12-13H,3-5,10-11H2,1-2H3,(H2,19,20,21)
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133n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315474
PNG
(US10172856, Example 122)
Show SMILES C\C=C\c1cc(ccc1N(Cc1cocn1)c1ccnc(N)n1)C#N
Show InChI InChI=1S/C18H16N6O/c1-2-3-14-8-13(9-19)4-5-16(14)24(10-15-11-25-12-22-15)17-6-7-21-18(20)23-17/h2-8,11-12H,10H2,1H3,(H2,20,21,23)/b3-2+
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134n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315405
PNG
(US10172856, Example 57)
Show SMILES CCN(c1ccnc(N)n1)c1ccc(cc1C1CC1)S(=O)(=O)CC
Show InChI InChI=1S/C17H22N4O2S/c1-3-21(16-9-10-19-17(18)20-16)15-8-7-13(24(22,23)4-2)11-14(15)12-5-6-12/h7-12H,3-6H2,1-2H3,(H2,18,19,20)
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134n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315422
PNG
(US10172856, Example 74)
Show SMILES CCc1cc(ccc1N(Cc1ccncn1)c1ccnc(N)n1)S(=O)(=O)C(F)(F)F
Show InChI InChI=1S/C18H17F3N6O2S/c1-2-12-9-14(30(28,29)18(19,20)21)3-4-15(12)27(10-13-5-7-23-11-25-13)16-6-8-24-17(22)26-16/h3-9,11H,2,10H2,1H3,(H2,22,24,26)
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155n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315443
PNG
(US10172856, Example 95)
Show SMILES CCOc1cc(F)ccc1N(Cc1ccno1)c1ccnc(N)n1
Show InChI InChI=1S/C16H16FN5O2/c1-2-23-14-9-11(17)3-4-13(14)22(10-12-5-8-20-24-12)15-6-7-19-16(18)21-15/h3-9H,2,10H2,1H3,(H2,18,19,21)
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160n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315417
PNG
(US10172856, Example 69)
Show SMILES CS(=O)(=O)c1ccc(N(Cc2ccn[nH]2)c2ccnc(N)n2)c(c1)C1CCC1
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162n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315407
PNG
(US10172856, Example 59)
Show SMILES CS(=O)(=O)c1ccc(N(Cc2cocn2)c2ccnc(N)n2)c(c1)C1CCC1
Show InChI InChI=1S/C19H21N5O3S/c1-28(25,26)15-5-6-17(16(9-15)13-3-2-4-13)24(10-14-11-27-12-22-14)18-7-8-21-19(20)23-18/h5-9,11-13H,2-4,10H2,1H3,(H2,20,21,23)
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170n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315451
PNG
(US10172856, Example 103)
Show SMILES CC(C)N(c1ccnc(N)n1)c1ccc(F)cc1OC(F)(F)F
Show InChI InChI=1S/C14H14F4N4O/c1-8(2)22(12-5-6-20-13(19)21-12)10-4-3-9(15)7-11(10)23-14(16,17)18/h3-8H,1-2H3,(H2,19,20,21)
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175n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315446
PNG
(US10172856, Example 98)
Show SMILES C\C=C\c1cc(ccc1N(Cc1cocn1)c1ccnc(N)n1)C(N)=O
Show InChI InChI=1S/C18H18N6O2/c1-2-3-12-8-13(17(19)25)4-5-15(12)24(9-14-10-26-11-22-14)16-6-7-21-18(20)23-16/h2-8,10-11H,9H2,1H3,(H2,19,25)(H2,20,21,23)/b3-2+
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176n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315409
PNG
(US10172856, Example 61)
Show SMILES CCN(c1ccnc(N)n1)c1ccc(cc1CC)S(C)(=O)=O
Show InChI InChI=1S/C15H20N4O2S/c1-4-11-10-12(22(3,20)21)6-7-13(11)19(5-2)14-8-9-17-15(16)18-14/h6-10H,4-5H2,1-3H3,(H2,16,17,18)
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179n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315416
PNG
(US10172856, Example 68)
Show SMILES CCc1cc(ccc1N(Cc1cocn1)c1ccnc(N)n1)S(C)(=O)=O
Show InChI InChI=1S/C17H19N5O3S/c1-3-12-8-14(26(2,23)24)4-5-15(12)22(9-13-10-25-11-20-13)16-6-7-19-17(18)21-16/h4-8,10-11H,3,9H2,1-2H3,(H2,18,19,21)
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243n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315444
PNG
(US10172856, Example 96)
Show SMILES CCOc1cc(F)ccc1N(Cc1nnco1)c1ccnc(N)n1
Show InChI InChI=1S/C15H15FN6O2/c1-2-23-12-7-10(16)3-4-11(12)22(8-14-21-19-9-24-14)13-5-6-18-15(17)20-13/h3-7,9H,2,8H2,1H3,(H2,17,18,20)
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249n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315452
PNG
(US10172856, Example 104)
Show SMILES CCOc1cc(F)ccc1N(Cc1cn[nH]n1)c1ccnc(N)n1
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294n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315441
PNG
(US10172856, Example 93)
Show SMILES CC(C)N(c1ccnc(N)n1)c1ccc(cc1C(F)(F)F)S(C)(=O)=O
Show InChI InChI=1S/C15H17F3N4O2S/c1-9(2)22(13-6-7-20-14(19)21-13)12-5-4-10(25(3,23)24)8-11(12)15(16,17)18/h4-9H,1-3H3,(H2,19,20,21)
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326n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315371
PNG
(US10172856, Example 24)
Show SMILES Cc1cc(ccc1N(Cc1cccnn1)c1ccnc(N)n1)S(F)(F)(F)(F)F
Show InChI InChI=1S/C16H15F5N6S/c1-11-9-13(28(17,18,19,20)21)4-5-14(11)27(10-12-3-2-7-24-26-12)15-6-8-23-16(22)25-15/h2-9H,10H2,1H3,(H2,22,23,25)
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334n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315413
PNG
(US10172856, Example 65)
Show SMILES CCc1cc(ccc1N(Cc1cccc(n1)C(F)(F)F)c1ccnc(N)n1)S(C)(=O)=O
Show InChI InChI=1S/C20H20F3N5O2S/c1-3-13-11-15(31(2,29)30)7-8-16(13)28(18-9-10-25-19(24)27-18)12-14-5-4-6-17(26-14)20(21,22)23/h4-11H,3,12H2,1-2H3,(H2,24,25,27)
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351n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315440
PNG
(US10172856, Example 92)
Show SMILES CCS(=O)(=O)c1ccc(N(Cc2cocn2)c2ccnc(N)n2)c(C)c1
Show InChI InChI=1S/C17H19N5O3S/c1-3-26(23,24)14-4-5-15(12(2)8-14)22(9-13-10-25-11-20-13)16-6-7-19-17(18)21-16/h4-8,10-11H,3,9H2,1-2H3,(H2,18,19,21)
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425n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315350
PNG
(US10172856, Example 3)
Show SMILES CCOc1cc(F)ccc1N(Cc1cnoc1)c1ccnc(N)n1
Show InChI InChI=1S/C16H16FN5O2/c1-2-23-14-7-12(17)3-4-13(14)22(9-11-8-20-24-10-11)15-5-6-19-16(18)21-15/h3-8,10H,2,9H2,1H3,(H2,18,19,21)
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492n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315418
PNG
(US10172856, Example 70)
Show SMILES CS(=O)(=O)c1ccc(N(Cc2ccncn2)c2ccnc(N)n2)c(c1)C1CCC1
Show InChI InChI=1S/C20H22N6O2S/c1-29(27,28)16-5-6-18(17(11-16)14-3-2-4-14)26(12-15-7-9-22-13-24-15)19-8-10-23-20(21)25-19/h5-11,13-14H,2-4,12H2,1H3,(H2,21,23,25)
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628n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315414
PNG
(US10172856, Example 66)
Show SMILES CCc1cc(ccc1N(CCOC)c1ccnc(N)n1)S(C)(=O)=O
Show InChI InChI=1S/C16H22N4O3S/c1-4-12-11-13(24(3,21)22)5-6-14(12)20(9-10-23-2)15-7-8-18-16(17)19-15/h5-8,11H,4,9-10H2,1-3H3,(H2,17,18,19)
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717n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315442
PNG
(US10172856, Example 94)
Show SMILES CC(C)N(c1ccnc(N)n1)c1ccc(cc1C(F)(F)F)S(=O)(=O)C(C)C
Show InChI InChI=1S/C17H21F3N4O2S/c1-10(2)24(15-7-8-22-16(21)23-15)14-6-5-12(27(25,26)11(3)4)9-13(14)17(18,19)20/h5-11H,1-4H3,(H2,21,22,23)
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981n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315415
PNG
(US10172856, Example 67)
Show SMILES CCc1cc(ccc1N(Cc1ccncn1)c1ccnc(N)n1)S(C)(=O)=O
Show InChI InChI=1S/C18H20N6O2S/c1-3-13-10-15(27(2,25)26)4-5-16(13)24(11-14-6-8-20-12-22-14)17-7-9-21-18(19)23-17/h4-10,12H,3,11H2,1-2H3,(H2,19,21,23)
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1.00E+3n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315427
PNG
(US10172856, Example 79)
Show SMILES CCOc1cc(F)ccc1N(Cc1coc(C)n1)c1ccnc(N)n1
Show InChI InChI=1S/C17H18FN5O2/c1-3-24-15-8-12(18)4-5-14(15)23(9-13-10-25-11(2)21-13)16-6-7-20-17(19)22-16/h4-8,10H,3,9H2,1-2H3,(H2,19,20,22)
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1.02E+3n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315426
PNG
(US10172856, Example 78)
Show SMILES CCOc1cc(F)ccc1N(Cc1cn2ccccc2n1)c1ccnc(N)n1
Show InChI InChI=1S/C20H19FN6O/c1-2-28-17-11-14(21)6-7-16(17)27(19-8-9-23-20(22)25-19)13-15-12-26-10-4-3-5-18(26)24-15/h3-12H,2,13H2,1H3,(H2,22,23,25)
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1.24E+3n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315456
PNG
(US10172856, Example 108)
Show SMILES CCOc1cc(F)ccc1N(Cc1nnc[nH]1)c1ccnc(N)n1
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1.47E+3n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (human))
BDBM315349
PNG
(US10172856, Example 2)
Show SMILES Cc1cc(F)ccc1N(Cc1ccn[nH]1)c1ccnc(N)n1
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>2.00E+3n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...


US Patent US10172856 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%