BindingDB logo
myBDB logout

Patent code US10172868

Compile Data Set for Download or QSAR
Found 103 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens)
BDBM318871
PNG
(N-(5-(2-((4-(4-methylpiperazin-1-yl)phenyl)amino)q...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3cccc(-c4cncc(NC(=O)C=C)c4)c3n2)cc1
Show InChI InChI=1S/C27H27N7O/c1-3-25(35)30-22-15-20(16-28-18-22)24-6-4-5-19-17-29-27(32-26(19)24)31-21-7-9-23(10-8-21)34-13-11-33(2)12-14-34/h3-10,15-18H,1,11-14H2,2H3,(H,30,35)(H,29,31,32)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens)
BDBM318874
PNG
(N-(2-fluoro-3-(2-((4-(4-methylpiperazin-1-yl)pheny...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4F)c3n2)cc1
Show InChI InChI=1S/C28H27FN6O/c1-3-25(36)32-24-9-5-7-22(26(24)29)23-8-4-6-19-18-30-28(33-27(19)23)31-20-10-12-21(13-11-20)35-16-14-34(2)15-17-35/h3-13,18H,1,14-17H2,2H3,(H,32,36)(H,30,31,33)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens)
BDBM318883
PNG
(N-(2-cyano-3-(2-((4-(4-methylpiperazin-1-yl)phenyl...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4C#N)c3n2)cc1
Show InChI InChI=1S/C29H27N7O/c1-3-27(37)33-26-9-5-7-23(25(26)18-30)24-8-4-6-20-19-31-29(34-28(20)24)32-21-10-12-22(13-11-21)36-16-14-35(2)15-17-36/h3-13,19H,1,14-17H2,2H3,(H,33,37)(H,31,32,34)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM318895
PNG
(N-(3-(2-((4-((1-(2-hydroxyethyl)azetidin-3-yl)amin...)
Show SMILES OCCN1CC(C1)Nc1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)cc1
Show InChI InChI=1S/C28H28N6O2/c1-2-26(36)31-23-7-3-5-19(15-23)25-8-4-6-20-16-29-28(33-27(20)25)32-22-11-9-21(10-12-22)30-24-17-34(18-24)13-14-35/h2-12,15-16,24,30,35H,1,13-14,17-18H2,(H,31,36)(H,29,32,33)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM318900
PNG
(N-(3-(2-((4-(2-hydroxyethoxy)phenyl)amino)quinazol...)
Show SMILES OCCOc1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)cc1
Show InChI InChI=1S/C25H22N4O3/c1-2-23(31)27-20-7-3-5-17(15-20)22-8-4-6-18-16-26-25(29-24(18)22)28-19-9-11-21(12-10-19)32-14-13-30/h2-12,15-16,30H,1,13-14H2,(H,27,31)(H,26,28,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens)
BDBM318906
PNG
(N-(3-(2-((4-((1-methylpiperidin-4-yl)oxy)phenyl)am...)
Show SMILES CN1CCC(CC1)Oc1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)cc1
Show InChI InChI=1S/C29H29N5O2/c1-3-27(35)31-23-8-4-6-20(18-23)26-9-5-7-21-19-30-29(33-28(21)26)32-22-10-12-24(13-11-22)36-25-14-16-34(2)17-15-25/h3-13,18-19,25H,1,14-17H2,2H3,(H,31,35)(H,30,32,33)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM318915
PNG
(N-(3-(2-((2-fluoro-4-(4-(2-hydroxyethyl)piperazin-...)
Show SMILES OCCN1CCN(CC1)c1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)c(F)c1
Show InChI InChI=1S/C29H29FN6O2/c1-2-27(38)32-22-7-3-5-20(17-22)24-8-4-6-21-19-31-29(34-28(21)24)33-26-10-9-23(18-25(26)30)36-13-11-35(12-14-36)15-16-37/h2-10,17-19,37H,1,11-16H2,(H,32,38)(H,31,33,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens)
BDBM318868
PNG
(N-(3-(2-((4-(4-methylpiperazin-1-yl)phenyl)amino)q...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)cc1
Show InChI InChI=1S/C28H28N6O/c1-3-26(35)30-23-8-4-6-20(18-23)25-9-5-7-21-19-29-28(32-27(21)25)31-22-10-12-24(13-11-22)34-16-14-33(2)15-17-34/h3-13,18-19H,1,14-17H2,2H3,(H,30,35)(H,29,31,32)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM318868
PNG
(N-(3-(2-((4-(4-methylpiperazin-1-yl)phenyl)amino)q...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)cc1
Show InChI InChI=1S/C28H28N6O/c1-3-26(35)30-23-8-4-6-20(18-23)25-9-5-7-21-19-29-28(32-27(21)25)31-22-10-12-24(13-11-22)34-16-14-33(2)15-17-34/h3-13,18-19H,1,14-17H2,2H3,(H,30,35)(H,29,31,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM318872
PNG
(N-(3-(2-((6-(4-methylpiperazin-1-yl)pyridin-3-yl)a...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)cn1
Show InChI InChI=1S/C27H27N7O/c1-3-25(35)30-21-8-4-6-19(16-21)23-9-5-7-20-17-29-27(32-26(20)23)31-22-10-11-24(28-18-22)34-14-12-33(2)13-15-34/h3-11,16-18H,1,12-15H2,2H3,(H,30,35)(H,29,31,32)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM318872
PNG
(N-(3-(2-((6-(4-methylpiperazin-1-yl)pyridin-3-yl)a...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)cn1
Show InChI InChI=1S/C27H27N7O/c1-3-25(35)30-21-8-4-6-19(16-21)23-9-5-7-20-17-29-27(32-26(20)23)31-22-10-11-24(28-18-22)34-14-12-33(2)13-15-34/h3-11,16-18H,1,12-15H2,2H3,(H,30,35)(H,29,31,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM318873
PNG
(N-(3-(2-((2-fluoro-4-(4-methylpiperazin-1-yl)pheny...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)c(F)c1
Show InChI InChI=1S/C28H27FN6O/c1-3-26(36)31-21-8-4-6-19(16-21)23-9-5-7-20-18-30-28(33-27(20)23)32-25-11-10-22(17-24(25)29)35-14-12-34(2)13-15-35/h3-11,16-18H,1,12-15H2,2H3,(H,31,36)(H,30,32,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens)
BDBM318878
PNG
(N-(4-(2-((4-(4-methylpiperazin-1-yl)phenyl)amino)q...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3cccc(-c4ccnc(NC(=O)C=C)c4)c3n2)cc1
Show InChI InChI=1S/C27H27N7O/c1-3-25(35)31-24-17-19(11-12-28-24)23-6-4-5-20-18-29-27(32-26(20)23)30-21-7-9-22(10-8-21)34-15-13-33(2)14-16-34/h3-12,17-18H,1,13-16H2,2H3,(H,28,31,35)(H,29,30,32)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens)
BDBM318896
PNG
(N-(3-(2-((4-((1-(2-fluoroethyl)azetidin-3-yl)amino...)
Show SMILES FCCN1CC(C1)Nc1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)cc1
Show InChI InChI=1S/C28H27FN6O/c1-2-26(36)32-23-7-3-5-19(15-23)25-8-4-6-20-16-30-28(34-27(20)25)33-22-11-9-21(10-12-22)31-24-17-35(18-24)14-13-29/h2-12,15-16,24,31H,1,13-14,17-18H2,(H,32,36)(H,30,33,34)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens)
BDBM318907
PNG
((S)-N-(3-(2-((4-((1-methylpyrrolidin-3-yl)amino)ph...)
Show SMILES CN1CC[C@@H](C1)Nc1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)cc1
Show InChI InChI=1S/C28H28N6O/c1-3-26(35)31-23-8-4-6-19(16-23)25-9-5-7-20-17-29-28(33-27(20)25)32-22-12-10-21(11-13-22)30-24-14-15-34(2)18-24/h3-13,16-17,24,30H,1,14-15,18H2,2H3,(H,31,35)(H,29,32,33)/t24-/m0/s1
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens)
BDBM318910
PNG
(N-(3-(2-((4-((1-(2-fluoroethyl)piperidin-4-yl)amin...)
Show SMILES FCCN1CCC(CC1)Nc1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)cc1
Show InChI InChI=1S/C30H31FN6O/c1-2-28(38)34-26-7-3-5-21(19-26)27-8-4-6-22-20-32-30(36-29(22)27)35-24-11-9-23(10-12-24)33-25-13-16-37(17-14-25)18-15-31/h2-12,19-20,25,33H,1,13-18H2,(H,34,38)(H,32,35,36)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens)
BDBM318912
PNG
(N-(3-(2-((2-fluoro-4-((1-methylpiperidin-4-yl)amin...)
Show SMILES CN1CCC(CC1)Nc1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)c(F)c1
Show InChI InChI=1S/C29H29FN6O/c1-3-27(37)33-22-8-4-6-19(16-22)24-9-5-7-20-18-31-29(35-28(20)24)34-26-11-10-23(17-25(26)30)32-21-12-14-36(2)15-13-21/h3-11,16-18,21,32H,1,12-15H2,2H3,(H,33,37)(H,31,34,35)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens)
BDBM318913
PNG
(N-(3-(2-((2-fluoro-4-((1-methylpiperidin-4-yl)oxy)...)
Show SMILES CN1CCC(CC1)Oc1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)c(F)c1
Show InChI InChI=1S/C29H28FN5O2/c1-3-27(36)32-21-8-4-6-19(16-21)24-9-5-7-20-18-31-29(34-28(20)24)33-26-11-10-23(17-25(26)30)37-22-12-14-35(2)15-13-22/h3-11,16-18,22H,1,12-15H2,2H3,(H,32,36)(H,31,33,34)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM318916
PNG
(N-(3-(2-((2,3-difluoro-4-(4-(2-hydroxyethyl)pipera...)
Show SMILES OCCN1CCN(CC1)c1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)c(F)c1F
Show InChI InChI=1S/C29H28F2N6O2/c1-2-25(39)33-21-7-3-5-19(17-21)22-8-4-6-20-18-32-29(35-28(20)22)34-23-9-10-24(27(31)26(23)30)37-13-11-36(12-14-37)15-16-38/h2-10,17-18,38H,1,11-16H2,(H,33,39)(H,32,34,35)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens)
BDBM318867
PNG
(N-(3-(2-((2-methoxy-4-(4-methylpiperazin-1-yl)phen...)
Show SMILES COc1cc(ccc1Nc1ncc2cccc(-c3cccc(NC(=O)C=C)c3)c2n1)N1CCN(C)CC1
Show InChI InChI=1S/C29H30N6O2/c1-4-27(36)31-22-9-5-7-20(17-22)24-10-6-8-21-19-30-29(33-28(21)24)32-25-12-11-23(18-26(25)37-3)35-15-13-34(2)14-16-35/h4-12,17-19H,1,13-16H2,2-3H3,(H,31,36)(H,30,32,33)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM318868
PNG
(N-(3-(2-((4-(4-methylpiperazin-1-yl)phenyl)amino)q...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)cc1
Show InChI InChI=1S/C28H28N6O/c1-3-26(35)30-23-8-4-6-20(18-23)25-9-5-7-21-19-29-28(32-27(21)25)31-22-10-12-24(13-11-22)34-16-14-33(2)15-17-34/h3-13,18-19H,1,14-17H2,2H3,(H,30,35)(H,29,31,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens)
BDBM318872
PNG
(N-(3-(2-((6-(4-methylpiperazin-1-yl)pyridin-3-yl)a...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)cn1
Show InChI InChI=1S/C27H27N7O/c1-3-25(35)30-21-8-4-6-19(16-21)23-9-5-7-20-17-29-27(32-26(20)23)31-22-10-11-24(28-18-22)34-14-12-33(2)13-15-34/h3-11,16-18H,1,12-15H2,2H3,(H,30,35)(H,29,31,32)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM318879
PNG
(N-(3-(2-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phen...)
Show SMILES OCCN1CCN(CC1)c1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)cc1
Show InChI InChI=1S/C29H30N6O2/c1-2-27(37)31-24-7-3-5-21(19-24)26-8-4-6-22-20-30-29(33-28(22)26)32-23-9-11-25(12-10-23)35-15-13-34(14-16-35)17-18-36/h2-12,19-20,36H,1,13-18H2,(H,31,37)(H,30,32,33)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens)
BDBM318881
PNG
(N-(2-methoxy-3-(2-((4-(4-methylpiperazin-1-yl)phen...)
Show SMILES COc1c(NC(=O)C=C)cccc1-c1cccc2cnc(Nc3ccc(cc3)N3CCN(C)CC3)nc12
Show InChI InChI=1S/C29H30N6O2/c1-4-26(36)32-25-10-6-9-24(28(25)37-3)23-8-5-7-20-19-30-29(33-27(20)23)31-21-11-13-22(14-12-21)35-17-15-34(2)16-18-35/h4-14,19H,1,15-18H2,2-3H3,(H,32,36)(H,30,31,33)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens)
BDBM318889
PNG
(N-(3-(2-((4-((3-fluoro-1-methylpiperidin-4-yl)oxy)...)
Show SMILES CN1CCC(Oc2ccc(Nc3ncc4cccc(-c5cccc(NC(=O)C=C)c5)c4n3)cc2)C(F)C1
Show InChI InChI=1S/C29H28FN5O2/c1-3-27(36)32-22-8-4-6-19(16-22)24-9-5-7-20-17-31-29(34-28(20)24)33-21-10-12-23(13-11-21)37-26-14-15-35(2)18-25(26)30/h3-13,16-17,25-26H,1,14-15,18H2,2H3,(H,32,36)(H,31,33,34)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens)
BDBM318891
PNG
(N-(3-(2-((5-chloro-6-(4-methylpiperazin-1-yl)pyrid...)
Show SMILES CN1CCN(CC1)c1ncc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)cc1Cl
Show InChI InChI=1S/C27H26ClN7O/c1-3-24(36)31-20-8-4-6-18(14-20)22-9-5-7-19-16-30-27(33-25(19)22)32-21-15-23(28)26(29-17-21)35-12-10-34(2)11-13-35/h3-9,14-17H,1,10-13H2,2H3,(H,31,36)(H,30,32,33)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens)
BDBM318897
PNG
(N-(3-(2-((4-((3-fluoro-1-methylpiperidin-4-yl)amin...)
Show SMILES CN1CCC(Nc2ccc(Nc3ncc4cccc(-c5cccc(NC(=O)C=C)c5)c4n3)cc2)C(F)C1
Show InChI InChI=1S/C29H29FN6O/c1-3-27(37)33-23-8-4-6-19(16-23)24-9-5-7-20-17-31-29(35-28(20)24)34-22-12-10-21(11-13-22)32-26-14-15-36(2)18-25(26)30/h3-13,16-17,25-26,32H,1,14-15,18H2,2H3,(H,33,37)(H,31,34,35)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens)
BDBM318898
PNG
(N-(3-(2-((4-(4-methyl-2-oxopiperazin-1-yl)phenyl)a...)
Show SMILES CN1CCN(C(=O)C1)c1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)cc1
Show InChI InChI=1S/C28H26N6O2/c1-3-25(35)30-22-8-4-6-19(16-22)24-9-5-7-20-17-29-28(32-27(20)24)31-21-10-12-23(13-11-21)34-15-14-33(2)18-26(34)36/h3-13,16-17H,1,14-15,18H2,2H3,(H,30,35)(H,29,31,32)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens)
BDBM318900
PNG
(N-(3-(2-((4-(2-hydroxyethoxy)phenyl)amino)quinazol...)
Show SMILES OCCOc1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)cc1
Show InChI InChI=1S/C25H22N4O3/c1-2-23(31)27-20-7-3-5-17(15-20)22-8-4-6-18-16-26-25(29-24(18)22)28-19-9-11-21(12-10-19)32-14-13-30/h2-12,15-16,30H,1,13-14H2,(H,27,31)(H,26,28,29)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens)
BDBM318904
PNG
((S)-N-(3-(2-((4-((1-methylpyrrolidin-3-yl)oxy)phen...)
Show SMILES CN1CC[C@@H](C1)Oc1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)cc1
Show InChI InChI=1S/C28H27N5O2/c1-3-26(34)30-22-8-4-6-19(16-22)25-9-5-7-20-17-29-28(32-27(20)25)31-21-10-12-23(13-11-21)35-24-14-15-33(2)18-24/h3-13,16-17,24H,1,14-15,18H2,2H3,(H,30,34)(H,29,31,32)/t24-/m0/s1
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens)
BDBM318911
PNG
(N-(3-(2-((4-((1-(2-hydroxyethyl)piperidin-4-yl)ami...)
Show SMILES OCCN1CCC(CC1)Nc1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)cc1
Show InChI InChI=1S/C30H32N6O2/c1-2-28(38)33-26-7-3-5-21(19-26)27-8-4-6-22-20-31-30(35-29(22)27)34-24-11-9-23(10-12-24)32-25-13-15-36(16-14-25)17-18-37/h2-12,19-20,25,32,37H,1,13-18H2,(H,33,38)(H,31,34,35)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens)
BDBM318915
PNG
(N-(3-(2-((2-fluoro-4-(4-(2-hydroxyethyl)piperazin-...)
Show SMILES OCCN1CCN(CC1)c1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)c(F)c1
Show InChI InChI=1S/C29H29FN6O2/c1-2-27(38)32-22-7-3-5-20(17-22)24-8-4-6-21-19-31-29(34-28(21)24)33-26-10-9-23(18-25(26)30)36-13-11-35(12-14-36)15-16-37/h2-10,17-19,37H,1,11-16H2,(H,32,38)(H,31,33,34)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM318916
PNG
(N-(3-(2-((2,3-difluoro-4-(4-(2-hydroxyethyl)pipera...)
Show SMILES OCCN1CCN(CC1)c1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)c(F)c1F
Show InChI InChI=1S/C29H28F2N6O2/c1-2-25(39)33-21-7-3-5-19(17-21)22-8-4-6-20-18-32-29(35-28(20)22)34-23-9-10-24(27(31)26(23)30)37-13-11-36(12-14-37)15-16-38/h2-10,17-18,38H,1,11-16H2,(H,33,39)(H,32,34,35)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM318917
PNG
(N-(3-(2-((2,3-difluoro-4-(4-methylpiperazin-1-yl)p...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)c(F)c1F
Show InChI InChI=1S/C28H26F2N6O/c1-3-24(37)32-20-8-4-6-18(16-20)21-9-5-7-19-17-31-28(34-27(19)21)33-22-10-11-23(26(30)25(22)29)36-14-12-35(2)13-15-36/h3-11,16-17H,1,12-15H2,2H3,(H,32,37)(H,31,33,34)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens)
BDBM318869
PNG
(N-(3-(2-((4-(4-acetylpiperazin-1-yl)phenyl)amino)q...)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)cc1
Show InChI InChI=1S/C29H28N6O2/c1-3-27(37)31-24-8-4-6-21(18-24)26-9-5-7-22-19-30-29(33-28(22)26)32-23-10-12-25(13-11-23)35-16-14-34(15-17-35)20(2)36/h3-13,18-19H,1,14-17H2,2H3,(H,31,37)(H,30,32,33)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM318870
PNG
(N-(3-(7-methyl-2-((4-(4-methylpiperazin-1-yl)pheny...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3ccc(C)c(-c4cccc(NC(=O)C=C)c4)c3n2)cc1
Show InChI InChI=1S/C29H30N6O/c1-4-26(36)31-24-7-5-6-21(18-24)27-20(2)8-9-22-19-30-29(33-28(22)27)32-23-10-12-25(13-11-23)35-16-14-34(3)15-17-35/h4-13,18-19H,1,14-17H2,2-3H3,(H,31,36)(H,30,32,33)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM318872
PNG
(N-(3-(2-((6-(4-methylpiperazin-1-yl)pyridin-3-yl)a...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)cn1
Show InChI InChI=1S/C27H27N7O/c1-3-25(35)30-21-8-4-6-19(16-21)23-9-5-7-20-17-29-27(32-26(20)23)31-22-10-11-24(28-18-22)34-14-12-33(2)13-15-34/h3-11,16-18H,1,12-15H2,2H3,(H,30,35)(H,29,31,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM318872
PNG
(N-(3-(2-((6-(4-methylpiperazin-1-yl)pyridin-3-yl)a...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)cn1
Show InChI InChI=1S/C27H27N7O/c1-3-25(35)30-21-8-4-6-19(16-21)23-9-5-7-20-17-29-27(32-26(20)23)31-22-10-11-24(28-18-22)34-14-12-33(2)13-15-34/h3-11,16-18H,1,12-15H2,2H3,(H,30,35)(H,29,31,32)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens)
BDBM318877
PNG
(N-(2-chloro-3-(2-((4-(4-methylpiperazin-1-yl)pheny...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4Cl)c3n2)cc1
Show InChI InChI=1S/C28H27ClN6O/c1-3-25(36)32-24-9-5-7-22(26(24)29)23-8-4-6-19-18-30-28(33-27(19)23)31-20-10-12-21(13-11-20)35-16-14-34(2)15-17-35/h3-13,18H,1,14-17H2,2H3,(H,32,36)(H,30,31,33)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens)
BDBM318882
PNG
(N-(4-fluoro-3-(2-((4-(4-methylpiperazin-1-yl)pheny...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3cccc(-c4cc(NC(=O)C=C)ccc4F)c3n2)cc1
Show InChI InChI=1S/C28H27FN6O/c1-3-26(36)31-21-9-12-25(29)24(17-21)23-6-4-5-19-18-30-28(33-27(19)23)32-20-7-10-22(11-8-20)35-15-13-34(2)14-16-35/h3-12,17-18H,1,13-16H2,2H3,(H,31,36)(H,30,32,33)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens)
BDBM318886
PNG
(N-(3-(2-((3-methoxy-4-(4-methylpiperazin-1-yl)phen...)
Show SMILES COc1cc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)ccc1N1CCN(C)CC1
Show InChI InChI=1S/C29H30N6O2/c1-4-27(36)31-22-9-5-7-20(17-22)24-10-6-8-21-19-30-29(33-28(21)24)32-23-11-12-25(26(18-23)37-3)35-15-13-34(2)14-16-35/h4-12,17-19H,1,13-16H2,2-3H3,(H,31,36)(H,30,32,33)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens)
BDBM318895
PNG
(N-(3-(2-((4-((1-(2-hydroxyethyl)azetidin-3-yl)amin...)
Show SMILES OCCN1CC(C1)Nc1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)cc1
Show InChI InChI=1S/C28H28N6O2/c1-2-26(36)31-23-7-3-5-19(15-23)25-8-4-6-20-16-29-28(33-27(20)25)32-22-11-9-21(10-12-22)30-24-17-34(18-24)13-14-35/h2-12,15-16,24,30,35H,1,13-14,17-18H2,(H,31,36)(H,29,32,33)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM318899
PNG
(N-(3-(2-((4-(2-methoxyethoxy)phenyl)amino)quinazol...)
Show SMILES COCCOc1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)cc1
Show InChI InChI=1S/C26H24N4O3/c1-3-24(31)28-21-8-4-6-18(16-21)23-9-5-7-19-17-27-26(30-25(19)23)29-20-10-12-22(13-11-20)33-15-14-32-2/h3-13,16-17H,1,14-15H2,2H3,(H,28,31)(H,27,29,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens)
BDBM318908
PNG
((R)-N-(3-(2-((4-((1-methylpyrrolidin-3-yl)amino)ph...)
Show SMILES CN1CC[C@H](C1)Nc1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)cc1
Show InChI InChI=1S/C28H28N6O/c1-3-26(35)31-23-8-4-6-19(16-23)25-9-5-7-20-17-29-28(33-27(20)25)32-22-12-10-21(11-13-22)30-24-14-15-34(2)18-24/h3-13,16-17,24,30H,1,14-15,18H2,2H3,(H,31,35)(H,29,32,33)/t24-/m1/s1
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens)
BDBM318917
PNG
(N-(3-(2-((2,3-difluoro-4-(4-methylpiperazin-1-yl)p...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)c(F)c1F
Show InChI InChI=1S/C28H26F2N6O/c1-3-24(37)32-20-8-4-6-18(16-20)21-9-5-7-19-17-31-28(34-27(19)21)33-22-10-11-23(26(30)25(22)29)36-14-12-35(2)13-15-36/h3-11,16-17H,1,12-15H2,2H3,(H,32,37)(H,31,33,34)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens)
BDBM318876
PNG
(N-(3-(2-((4-(4-acetylpiperazin-1-yl)phenyl)amino)q...)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4F)c3n2)cc1
Show InChI InChI=1S/C29H27FN6O2/c1-3-26(38)33-25-9-5-7-23(27(25)30)24-8-4-6-20-18-31-29(34-28(20)24)32-21-10-12-22(13-11-21)36-16-14-35(15-17-36)19(2)37/h3-13,18H,1,14-17H2,2H3,(H,33,38)(H,31,32,34)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM318879
PNG
(N-(3-(2-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phen...)
Show SMILES OCCN1CCN(CC1)c1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)cc1
Show InChI InChI=1S/C29H30N6O2/c1-2-27(37)31-24-7-3-5-21(19-24)26-8-4-6-22-20-30-29(33-28(22)26)32-23-9-11-25(12-10-23)35-15-13-34(14-16-35)17-18-36/h2-12,19-20,36H,1,13-18H2,(H,31,37)(H,30,32,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens)
BDBM318885
PNG
(N-(3-(2-((3-cyano-4-(4-methylpiperazin-1-yl)phenyl...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)cc1C#N
Show InChI InChI=1S/C29H27N7O/c1-3-27(37)32-23-8-4-6-20(16-23)25-9-5-7-21-19-31-29(34-28(21)25)33-24-10-11-26(22(17-24)18-30)36-14-12-35(2)13-15-36/h3-11,16-17,19H,1,12-15H2,2H3,(H,32,37)(H,31,33,34)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens)
BDBM318892
PNG
(5-((8-(3-acrylamidophenyl)quinazolin-2-yl)amino)-2...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)cc1C(N)=O
Show InChI InChI=1S/C29H29N7O2/c1-3-26(37)32-21-8-4-6-19(16-21)23-9-5-7-20-18-31-29(34-27(20)23)33-22-10-11-25(24(17-22)28(30)38)36-14-12-35(2)13-15-36/h3-11,16-18H,1,12-15H2,2H3,(H2,30,38)(H,32,37)(H,31,33,34)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM318892
PNG
(5-((8-(3-acrylamidophenyl)quinazolin-2-yl)amino)-2...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)cc1C(N)=O
Show InChI InChI=1S/C29H29N7O2/c1-3-26(37)32-21-8-4-6-19(16-21)23-9-5-7-20-18-31-29(34-27(20)23)33-22-10-11-25(24(17-22)28(30)38)36-14-12-35(2)13-15-36/h3-11,16-18H,1,12-15H2,2H3,(H2,30,38)(H,32,37)(H,31,33,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens)
BDBM318893
PNG
(N-(3-(7-fluoro-2-((4-(4-methylpiperazin-1-yl)pheny...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3ccc(F)c(-c4cccc(NC(=O)C=C)c4)c3n2)cc1
Show InChI InChI=1S/C28H27FN6O/c1-3-25(36)31-22-6-4-5-19(17-22)26-24(29)12-7-20-18-30-28(33-27(20)26)32-21-8-10-23(11-9-21)35-15-13-34(2)14-16-35/h3-12,17-18H,1,13-16H2,2H3,(H,31,36)(H,30,32,33)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM318897
PNG
(N-(3-(2-((4-((3-fluoro-1-methylpiperidin-4-yl)amin...)
Show SMILES CN1CCC(Nc2ccc(Nc3ncc4cccc(-c5cccc(NC(=O)C=C)c5)c4n3)cc2)C(F)C1
Show InChI InChI=1S/C29H29FN6O/c1-3-27(37)33-23-8-4-6-19(16-23)24-9-5-7-20-17-31-29(35-28(20)24)34-22-12-10-21(11-13-22)32-26-14-15-36(2)18-25(26)30/h3-13,16-17,25-26,32H,1,14-15,18H2,2H3,(H,33,37)(H,31,34,35)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens)
BDBM318901
PNG
(N-(3-(2-((4-(2-(azetidin-1-yl)ethoxy)phenyl)amino)...)
Show SMILES C=CC(=O)Nc1cccc(c1)-c1cccc2cnc(Nc3ccc(OCCN4CCC4)cc3)nc12
Show InChI InChI=1S/C28H27N5O2/c1-2-26(34)30-23-8-3-6-20(18-23)25-9-4-7-21-19-29-28(32-27(21)25)31-22-10-12-24(13-11-22)35-17-16-33-14-5-15-33/h2-4,6-13,18-19H,1,5,14-17H2,(H,30,34)(H,29,31,32)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens)
BDBM318903
PNG
(N-(3-(2-((4-((1-methylpiperidin-4-yl)amino)phenyl)...)
Show SMILES CN1CCC(CC1)Nc1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)cc1
Show InChI InChI=1S/C29H30N6O/c1-3-27(36)32-25-8-4-6-20(18-25)26-9-5-7-21-19-30-29(34-28(21)26)33-23-12-10-22(11-13-23)31-24-14-16-35(2)17-15-24/h3-13,18-19,24,31H,1,14-17H2,2H3,(H,32,36)(H,30,33,34)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens)
BDBM318905
PNG
((R)-N-(3-(2-((4-((1-methylpyrrolidin-3-yl)oxy)phen...)
Show SMILES CN1CC[C@H](C1)Oc1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)cc1
Show InChI InChI=1S/C28H27N5O2/c1-3-26(34)30-22-8-4-6-19(16-22)25-9-5-7-20-17-29-28(32-27(20)25)31-21-10-12-23(13-11-21)35-24-14-15-33(2)18-24/h3-13,16-17,24H,1,14-15,18H2,2H3,(H,30,34)(H,29,31,32)/t24-/m1/s1
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM318915
PNG
(N-(3-(2-((2-fluoro-4-(4-(2-hydroxyethyl)piperazin-...)
Show SMILES OCCN1CCN(CC1)c1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)c(F)c1
Show InChI InChI=1S/C29H29FN6O2/c1-2-27(38)32-22-7-3-5-20(17-22)24-8-4-6-21-19-31-29(34-28(21)24)33-26-10-9-23(18-25(26)30)36-13-11-35(12-14-36)15-16-37/h2-10,17-19,37H,1,11-16H2,(H,32,38)(H,31,33,34)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens)
BDBM318916
PNG
(N-(3-(2-((2,3-difluoro-4-(4-(2-hydroxyethyl)pipera...)
Show SMILES OCCN1CCN(CC1)c1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)c(F)c1F
Show InChI InChI=1S/C29H28F2N6O2/c1-2-25(39)33-21-7-3-5-19(17-21)22-8-4-6-20-18-32-29(35-28(20)22)34-23-9-10-24(27(31)26(23)30)37-13-11-36(12-14-37)15-16-38/h2-10,17-18,38H,1,11-16H2,(H,33,39)(H,32,34,35)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM318868
PNG
(N-(3-(2-((4-(4-methylpiperazin-1-yl)phenyl)amino)q...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)cc1
Show InChI InChI=1S/C28H28N6O/c1-3-26(35)30-23-8-4-6-20(18-23)25-9-5-7-21-19-29-28(32-27(21)25)31-22-10-12-24(13-11-22)34-16-14-33(2)15-17-34/h3-13,18-19H,1,14-17H2,2H3,(H,30,35)(H,29,31,32)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens)
BDBM318870
PNG
(N-(3-(7-methyl-2-((4-(4-methylpiperazin-1-yl)pheny...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3ccc(C)c(-c4cccc(NC(=O)C=C)c4)c3n2)cc1
Show InChI InChI=1S/C29H30N6O/c1-4-26(36)31-24-7-5-6-21(18-24)27-20(2)8-9-22-19-30-29(33-28(22)27)32-23-10-12-25(13-11-23)35-16-14-34(3)15-17-35/h4-13,18-19H,1,14-17H2,2-3H3,(H,31,36)(H,30,32,33)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM318872
PNG
(N-(3-(2-((6-(4-methylpiperazin-1-yl)pyridin-3-yl)a...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)cn1
Show InChI InChI=1S/C27H27N7O/c1-3-25(35)30-21-8-4-6-19(16-21)23-9-5-7-20-17-29-27(32-26(20)23)31-22-10-11-24(28-18-22)34-14-12-33(2)13-15-34/h3-11,16-18H,1,12-15H2,2H3,(H,30,35)(H,29,31,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM318873
PNG
(N-(3-(2-((2-fluoro-4-(4-methylpiperazin-1-yl)pheny...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)c(F)c1
Show InChI InChI=1S/C28H27FN6O/c1-3-26(36)31-21-8-4-6-19(16-21)23-9-5-7-20-18-30-28(33-27(20)23)32-25-11-10-22(17-24(25)29)35-14-12-34(2)13-15-35/h3-11,16-18H,1,12-15H2,2H3,(H,31,36)(H,30,32,33)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens)
BDBM318873
PNG
(N-(3-(2-((2-fluoro-4-(4-methylpiperazin-1-yl)pheny...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)c(F)c1
Show InChI InChI=1S/C28H27FN6O/c1-3-26(36)31-21-8-4-6-19(16-21)23-9-5-7-20-18-30-28(33-27(20)23)32-25-11-10-22(17-24(25)29)35-14-12-34(2)13-15-35/h3-11,16-18H,1,12-15H2,2H3,(H,31,36)(H,30,32,33)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM318879
PNG
(N-(3-(2-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phen...)
Show SMILES OCCN1CCN(CC1)c1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)cc1
Show InChI InChI=1S/C29H30N6O2/c1-2-27(37)31-24-7-3-5-21(19-24)26-8-4-6-22-20-30-29(33-28(22)26)32-23-9-11-25(12-10-23)35-15-13-34(14-16-35)17-18-36/h2-12,19-20,36H,1,13-18H2,(H,31,37)(H,30,32,33)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens)
BDBM318879
PNG
(N-(3-(2-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phen...)
Show SMILES OCCN1CCN(CC1)c1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)cc1
Show InChI InChI=1S/C29H30N6O2/c1-2-27(37)31-24-7-3-5-21(19-24)26-8-4-6-22-20-30-29(33-28(22)26)32-23-9-11-25(12-10-23)35-15-13-34(14-16-35)17-18-36/h2-12,19-20,36H,1,13-18H2,(H,31,37)(H,30,32,33)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM318897
PNG
(N-(3-(2-((4-((3-fluoro-1-methylpiperidin-4-yl)amin...)
Show SMILES CN1CCC(Nc2ccc(Nc3ncc4cccc(-c5cccc(NC(=O)C=C)c5)c4n3)cc2)C(F)C1
Show InChI InChI=1S/C29H29FN6O/c1-3-27(37)33-23-8-4-6-19(16-23)24-9-5-7-20-17-31-29(35-28(20)24)34-22-12-10-21(11-13-22)32-26-14-15-36(2)18-25(26)30/h3-13,16-17,25-26,32H,1,14-15,18H2,2H3,(H,33,37)(H,31,34,35)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM318898
PNG
(N-(3-(2-((4-(4-methyl-2-oxopiperazin-1-yl)phenyl)a...)
Show SMILES CN1CCN(C(=O)C1)c1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)cc1
Show InChI InChI=1S/C28H26N6O2/c1-3-25(35)30-22-8-4-6-19(16-22)24-9-5-7-20-17-29-28(32-27(20)24)31-21-10-12-23(13-11-21)34-15-14-33(2)18-26(34)36/h3-13,16-17H,1,14-15,18H2,2H3,(H,30,35)(H,29,31,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens)
BDBM318909
PNG
(N-(3-(2-((4-((1-(2-hydroxyethyl)piperidin-4-yl)oxy...)
Show SMILES OCCN1CCC(CC1)Oc1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)cc1
Show InChI InChI=1S/C30H31N5O3/c1-2-28(37)32-24-7-3-5-21(19-24)27-8-4-6-22-20-31-30(34-29(22)27)33-23-9-11-25(12-10-23)38-26-13-15-35(16-14-26)17-18-36/h2-12,19-20,26,36H,1,13-18H2,(H,32,37)(H,31,33,34)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens)
BDBM318914
PNG
(N-(3-(2-((4-(4-(2-hydroxy-2-methylpropyl)piperazin...)
Show SMILES CC(C)(O)CN1CCN(CC1)c1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)cc1
Show InChI InChI=1S/C31H34N6O2/c1-4-28(38)33-25-9-5-7-22(19-25)27-10-6-8-23-20-32-30(35-29(23)27)34-24-11-13-26(14-12-24)37-17-15-36(16-18-37)21-31(2,3)39/h4-14,19-20,39H,1,15-18,21H2,2-3H3,(H,33,38)(H,32,34,35)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM318871
PNG
(N-(5-(2-((4-(4-methylpiperazin-1-yl)phenyl)amino)q...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3cccc(-c4cncc(NC(=O)C=C)c4)c3n2)cc1
Show InChI InChI=1S/C27H27N7O/c1-3-25(35)30-22-15-20(16-28-18-22)24-6-4-5-19-17-29-27(32-26(19)24)31-21-7-9-23(10-8-21)34-13-11-33(2)12-14-34/h3-10,15-18H,1,11-14H2,2H3,(H,30,35)(H,29,31,32)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM318873
PNG
(N-(3-(2-((2-fluoro-4-(4-methylpiperazin-1-yl)pheny...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)c(F)c1
Show InChI InChI=1S/C28H27FN6O/c1-3-26(36)31-21-8-4-6-19(16-21)23-9-5-7-20-18-30-28(33-27(20)23)32-25-11-10-22(17-24(25)29)35-14-12-34(2)13-15-35/h3-11,16-18H,1,12-15H2,2H3,(H,31,36)(H,30,32,33)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM318879
PNG
(N-(3-(2-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phen...)
Show SMILES OCCN1CCN(CC1)c1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)cc1
Show InChI InChI=1S/C29H30N6O2/c1-2-27(37)31-24-7-3-5-21(19-24)26-8-4-6-22-20-30-29(33-28(22)26)32-23-9-11-25(12-10-23)35-15-13-34(14-16-35)17-18-36/h2-12,19-20,36H,1,13-18H2,(H,31,37)(H,30,32,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens)
BDBM318884
PNG
(N-(3-(2-((3-chloro-4-(4-methylpiperazin-1-yl)pheny...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)cc1Cl
Show InChI InChI=1S/C28H27ClN6O/c1-3-26(36)31-21-8-4-6-19(16-21)23-9-5-7-20-18-30-28(33-27(20)23)32-22-10-11-25(24(29)17-22)35-14-12-34(2)13-15-35/h3-11,16-18H,1,12-15H2,2H3,(H,31,36)(H,30,32,33)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens)
BDBM318887
PNG
(N-(3-(2-((4-(3-(hydroxymethyl)-4-methylpiperazin-1...)
Show SMILES CN1CCN(CC1CO)c1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)cc1
Show InChI InChI=1S/C29H30N6O2/c1-3-27(37)31-23-8-4-6-20(16-23)26-9-5-7-21-17-30-29(33-28(21)26)32-22-10-12-24(13-11-22)35-15-14-34(2)25(18-35)19-36/h3-13,16-17,25,36H,1,14-15,18-19H2,2H3,(H,31,37)(H,30,32,33)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens)
BDBM318890
PNG
(N-(2-fluoro-3-(2-((4-((3-fluoro-1-methylpiperidin-...)
Show SMILES CN1CCC(Oc2ccc(Nc3ncc4cccc(-c5cccc(NC(=O)C=C)c5F)c4n3)cc2)C(F)C1
Show InChI InChI=1S/C29H27F2N5O2/c1-3-26(37)34-24-9-5-7-21(27(24)31)22-8-4-6-18-16-32-29(35-28(18)22)33-19-10-12-20(13-11-19)38-25-14-15-36(2)17-23(25)30/h3-13,16,23,25H,1,14-15,17H2,2H3,(H,34,37)(H,32,33,35)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM318868
PNG
(N-(3-(2-((4-(4-methylpiperazin-1-yl)phenyl)amino)q...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)cc1
Show InChI InChI=1S/C28H28N6O/c1-3-26(35)30-23-8-4-6-20(18-23)25-9-5-7-21-19-29-28(32-27(21)25)31-22-10-12-24(13-11-22)34-16-14-33(2)15-17-34/h3-13,18-19H,1,14-17H2,2H3,(H,30,35)(H,29,31,32)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM318875
PNG
(N-(2-fluoro-3-(2-((6-(4-methylpiperazin-1-yl)pyrid...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4F)c3n2)cn1
Show InChI InChI=1S/C27H26FN7O/c1-3-24(36)32-22-9-5-7-20(25(22)28)21-8-4-6-18-16-30-27(33-26(18)21)31-19-10-11-23(29-17-19)35-14-12-34(2)13-15-35/h3-11,16-17H,1,12-15H2,2H3,(H,32,36)(H,30,31,33)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens)
BDBM318875
PNG
(N-(2-fluoro-3-(2-((6-(4-methylpiperazin-1-yl)pyrid...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4F)c3n2)cn1
Show InChI InChI=1S/C27H26FN7O/c1-3-24(36)32-22-9-5-7-20(25(22)28)21-8-4-6-18-16-30-27(33-26(18)21)31-19-10-11-23(29-17-19)35-14-12-34(2)13-15-35/h3-11,16-17H,1,12-15H2,2H3,(H,32,36)(H,30,31,33)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM318879
PNG
(N-(3-(2-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phen...)
Show SMILES OCCN1CCN(CC1)c1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)cc1
Show InChI InChI=1S/C29H30N6O2/c1-2-27(37)31-24-7-3-5-21(19-24)26-8-4-6-22-20-30-29(33-28(22)26)32-23-9-11-25(12-10-23)35-15-13-34(14-16-35)17-18-36/h2-12,19-20,36H,1,13-18H2,(H,31,37)(H,30,32,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens)
BDBM318880
PNG
(N-(2-fluoro-3-(2-((4-(4-(2-fluoroethyl)piperazin-1...)
Show SMILES FCCN1CCN(CC1)c1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4F)c3n2)cc1
Show InChI InChI=1S/C29H28F2N6O/c1-2-26(38)34-25-8-4-6-23(27(25)31)24-7-3-5-20-19-32-29(35-28(20)24)33-21-9-11-22(12-10-21)37-17-15-36(14-13-30)16-18-37/h2-12,19H,1,13-18H2,(H,34,38)(H,32,33,35)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens)
BDBM318888
PNG
(N-(3-(2-((4-((1-(2-fluoroethyl)azetidin-3-yl)oxy)p...)
Show SMILES FCCN1CC(C1)Oc1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)cc1
Show InChI InChI=1S/C28H26FN5O2/c1-2-26(35)31-22-7-3-5-19(15-22)25-8-4-6-20-16-30-28(33-27(20)25)32-21-9-11-23(12-10-21)36-24-17-34(18-24)14-13-29/h2-12,15-16,24H,1,13-14,17-18H2,(H,31,35)(H,30,32,33)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM318889
PNG
(N-(3-(2-((4-((3-fluoro-1-methylpiperidin-4-yl)oxy)...)
Show SMILES CN1CCC(Oc2ccc(Nc3ncc4cccc(-c5cccc(NC(=O)C=C)c5)c4n3)cc2)C(F)C1
Show InChI InChI=1S/C29H28FN5O2/c1-3-27(36)32-22-8-4-6-19(16-22)24-9-5-7-20-17-31-29(34-28(20)24)33-21-10-12-23(13-11-21)37-26-14-15-35(2)18-25(26)30/h3-13,16-17,25-26H,1,14-15,18H2,2H3,(H,32,36)(H,31,33,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens)
BDBM318894
PNG
(N-(3-(7-fluoro-2-((4-(4-(2-fluoroethyl)piperazin-1...)
Show SMILES FCCN1CCN(CC1)c1ccc(Nc2ncc3ccc(F)c(-c4cccc(NC(=O)C=C)c4)c3n2)cc1
Show InChI InChI=1S/C29H28F2N6O/c1-2-26(38)33-23-5-3-4-20(18-23)27-25(31)11-6-21-19-32-29(35-28(21)27)34-22-7-9-24(10-8-22)37-16-14-36(13-12-30)15-17-37/h2-11,18-19H,1,12-17H2,(H,33,38)(H,32,34,35)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM318895
PNG
(N-(3-(2-((4-((1-(2-hydroxyethyl)azetidin-3-yl)amin...)
Show SMILES OCCN1CC(C1)Nc1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)cc1
Show InChI InChI=1S/C28H28N6O2/c1-2-26(36)31-23-7-3-5-19(15-23)25-8-4-6-20-16-29-28(33-27(20)25)32-22-11-9-21(10-12-22)30-24-17-34(18-24)13-14-35/h2-12,15-16,24,30,35H,1,13-14,17-18H2,(H,31,36)(H,29,32,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens)
BDBM318899
PNG
(N-(3-(2-((4-(2-methoxyethoxy)phenyl)amino)quinazol...)
Show SMILES COCCOc1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)cc1
Show InChI InChI=1S/C26H24N4O3/c1-3-24(31)28-21-8-4-6-18(16-21)23-9-5-7-19-17-27-26(30-25(19)23)29-20-10-12-22(13-11-20)33-15-14-32-2/h3-13,16-17H,1,14-15H2,2H3,(H,28,31)(H,27,29,30)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens)
BDBM318902
PNG
(N-(3-(2-((4-(2-(dimethylamino)ethoxy)phenyl)amino)...)
Show SMILES CN(C)CCOc1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)cc1
Show InChI InChI=1S/C27H27N5O2/c1-4-25(33)29-22-9-5-7-19(17-22)24-10-6-8-20-18-28-27(31-26(20)24)30-21-11-13-23(14-12-21)34-16-15-32(2)3/h4-14,17-18H,1,15-16H2,2-3H3,(H,29,33)(H,28,30,31)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens)
BDBM318866
PNG
(N-(3-(2-((4-morpholinophenyl)amino)quinazolin-8-yl...)
Show SMILES C=CC(=O)Nc1cccc(c1)-c1cccc2cnc(Nc3ccc(cc3)N3CCOCC3)nc12
Show InChI InChI=1S/C27H25N5O2/c1-2-25(33)29-22-7-3-5-19(17-22)24-8-4-6-20-18-28-27(31-26(20)24)30-21-9-11-23(12-10-21)32-13-15-34-16-14-32/h2-12,17-18H,1,13-16H2,(H,29,33)(H,28,30,31)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM318868
PNG
(N-(3-(2-((4-(4-methylpiperazin-1-yl)phenyl)amino)q...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)cc1
Show InChI InChI=1S/C28H28N6O/c1-3-26(35)30-23-8-4-6-20(18-23)25-9-5-7-21-19-29-28(32-27(21)25)31-22-10-12-24(13-11-22)34-16-14-33(2)15-17-34/h3-13,18-19H,1,14-17H2,2H3,(H,30,35)(H,29,31,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM318868
PNG
(N-(3-(2-((4-(4-methylpiperazin-1-yl)phenyl)amino)q...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)cc1
Show InChI InChI=1S/C28H28N6O/c1-3-26(35)30-23-8-4-6-20(18-23)25-9-5-7-21-19-29-28(32-27(21)25)31-22-10-12-24(13-11-22)34-16-14-33(2)15-17-34/h3-13,18-19H,1,14-17H2,2H3,(H,30,35)(H,29,31,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM318873
PNG
(N-(3-(2-((2-fluoro-4-(4-methylpiperazin-1-yl)pheny...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)c(F)c1
Show InChI InChI=1S/C28H27FN6O/c1-3-26(36)31-21-8-4-6-19(16-21)23-9-5-7-20-18-30-28(33-27(20)23)32-25-11-10-22(17-24(25)29)35-14-12-34(2)13-15-35/h3-11,16-18H,1,12-15H2,2H3,(H,31,36)(H,30,32,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 300n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM318900
PNG
(N-(3-(2-((4-(2-hydroxyethoxy)phenyl)amino)quinazol...)
Show SMILES OCCOc1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)cc1
Show InChI InChI=1S/C25H22N4O3/c1-2-23(31)27-20-7-3-5-17(15-20)22-8-4-6-18-16-26-25(29-24(18)22)28-19-9-11-21(12-10-19)32-14-13-30/h2-12,15-16,30H,1,13-14H2,(H,27,31)(H,26,28,29)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 300n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM318916
PNG
(N-(3-(2-((2,3-difluoro-4-(4-(2-hydroxyethyl)pipera...)
Show SMILES OCCN1CCN(CC1)c1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)c(F)c1F
Show InChI InChI=1S/C29H28F2N6O2/c1-2-25(39)33-21-7-3-5-19(17-21)22-8-4-6-20-18-32-29(35-28(20)22)34-23-9-10-24(27(31)26(23)30)37-13-11-36(12-14-37)15-16-38/h2-10,17-18,38H,1,11-16H2,(H,33,39)(H,32,34,35)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 300n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM318879
PNG
(N-(3-(2-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phen...)
Show SMILES OCCN1CCN(CC1)c1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)cc1
Show InChI InChI=1S/C29H30N6O2/c1-2-27(37)31-24-7-3-5-21(19-24)26-8-4-6-22-20-30-29(33-28(22)26)32-23-9-11-25(12-10-23)35-15-13-34(14-16-35)17-18-36/h2-12,19-20,36H,1,13-18H2,(H,31,37)(H,30,32,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 300n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM318889
PNG
(N-(3-(2-((4-((3-fluoro-1-methylpiperidin-4-yl)oxy)...)
Show SMILES CN1CCC(Oc2ccc(Nc3ncc4cccc(-c5cccc(NC(=O)C=C)c5)c4n3)cc2)C(F)C1
Show InChI InChI=1S/C29H28FN5O2/c1-3-27(36)32-22-8-4-6-19(16-22)24-9-5-7-20-17-31-29(34-28(20)24)33-21-10-12-23(13-11-21)37-26-14-15-35(2)18-25(26)30/h3-13,16-17,25-26H,1,14-15,18H2,2H3,(H,32,36)(H,31,33,34)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 300n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM318916
PNG
(N-(3-(2-((2,3-difluoro-4-(4-(2-hydroxyethyl)pipera...)
Show SMILES OCCN1CCN(CC1)c1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)c(F)c1F
Show InChI InChI=1S/C29H28F2N6O2/c1-2-25(39)33-21-7-3-5-19(17-21)22-8-4-6-20-18-32-29(35-28(20)22)34-23-9-10-24(27(31)26(23)30)37-13-11-36(12-14-37)15-16-38/h2-10,17-18,38H,1,11-16H2,(H,33,39)(H,32,34,35)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 300n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM318915
PNG
(N-(3-(2-((2-fluoro-4-(4-(2-hydroxyethyl)piperazin-...)
Show SMILES OCCN1CCN(CC1)c1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)c(F)c1
Show InChI InChI=1S/C29H29FN6O2/c1-2-27(38)32-22-7-3-5-20(17-22)24-8-4-6-21-19-31-29(34-28(21)24)33-26-10-9-23(18-25(26)30)36-13-11-35(12-14-36)15-16-37/h2-10,17-19,37H,1,11-16H2,(H,32,38)(H,31,33,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 300n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM318869
PNG
(N-(3-(2-((4-(4-acetylpiperazin-1-yl)phenyl)amino)q...)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)cc1
Show InChI InChI=1S/C29H28N6O2/c1-3-27(37)31-24-8-4-6-21(18-24)26-9-5-7-22-19-30-29(33-28(22)26)32-23-10-12-25(13-11-23)35-16-14-34(15-17-35)20(2)36/h3-13,18-19H,1,14-17H2,2H3,(H,31,37)(H,30,32,33)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 300n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM318873
PNG
(N-(3-(2-((2-fluoro-4-(4-methylpiperazin-1-yl)pheny...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)c(F)c1
Show InChI InChI=1S/C28H27FN6O/c1-3-26(36)31-21-8-4-6-19(16-21)23-9-5-7-20-18-30-28(33-27(20)23)32-25-11-10-22(17-24(25)29)35-14-12-34(2)13-15-35/h3-11,16-18H,1,12-15H2,2H3,(H,31,36)(H,30,32,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 300n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM318915
PNG
(N-(3-(2-((2-fluoro-4-(4-(2-hydroxyethyl)piperazin-...)
Show SMILES OCCN1CCN(CC1)c1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)c(F)c1
Show InChI InChI=1S/C29H29FN6O2/c1-2-27(38)32-22-7-3-5-20(17-22)24-8-4-6-21-19-31-29(34-28(21)24)33-26-10-9-23(18-25(26)30)36-13-11-35(12-14-36)15-16-37/h2-10,17-19,37H,1,11-16H2,(H,32,38)(H,31,33,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 300n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM318916
PNG
(N-(3-(2-((2,3-difluoro-4-(4-(2-hydroxyethyl)pipera...)
Show SMILES OCCN1CCN(CC1)c1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)c(F)c1F
Show InChI InChI=1S/C29H28F2N6O2/c1-2-25(39)33-21-7-3-5-19(17-21)22-8-4-6-20-18-32-29(35-28(20)22)34-23-9-10-24(27(31)26(23)30)37-13-11-36(12-14-37)15-16-38/h2-10,17-18,38H,1,11-16H2,(H,33,39)(H,32,34,35)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 300n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM318892
PNG
(5-((8-(3-acrylamidophenyl)quinazolin-2-yl)amino)-2...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)cc1C(N)=O
Show InChI InChI=1S/C29H29N7O2/c1-3-26(37)32-21-8-4-6-19(16-21)23-9-5-7-20-18-31-29(34-27(20)23)33-22-10-11-25(24(17-22)28(30)38)36-14-12-35(2)13-15-36/h3-11,16-18H,1,12-15H2,2H3,(H2,30,38)(H,32,37)(H,31,33,34)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 300n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM318915
PNG
(N-(3-(2-((2-fluoro-4-(4-(2-hydroxyethyl)piperazin-...)
Show SMILES OCCN1CCN(CC1)c1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)c(F)c1
Show InChI InChI=1S/C29H29FN6O2/c1-2-27(38)32-22-7-3-5-20(17-22)24-8-4-6-21-19-31-29(34-28(21)24)33-26-10-9-23(18-25(26)30)36-13-11-35(12-14-36)15-16-37/h2-10,17-19,37H,1,11-16H2,(H,32,38)(H,31,33,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 300n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM318898
PNG
(N-(3-(2-((4-(4-methyl-2-oxopiperazin-1-yl)phenyl)a...)
Show SMILES CN1CCN(C(=O)C1)c1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)cc1
Show InChI InChI=1S/C28H26N6O2/c1-3-25(35)30-22-8-4-6-19(16-22)24-9-5-7-20-17-29-28(32-27(20)24)31-21-10-12-23(13-11-21)34-15-14-33(2)18-26(34)36/h3-13,16-17H,1,14-15,18H2,2H3,(H,30,35)(H,29,31,32)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>500n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM318899
PNG
(N-(3-(2-((4-(2-methoxyethoxy)phenyl)amino)quinazol...)
Show SMILES COCCOc1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)cc1
Show InChI InChI=1S/C26H24N4O3/c1-3-24(31)28-21-8-4-6-18(16-21)23-9-5-7-19-17-27-26(30-25(19)23)29-20-10-12-22(13-11-20)33-15-14-32-2/h3-13,16-17H,1,14-15H2,2H3,(H,28,31)(H,27,29,30)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>500n/an/an/an/an/an/a



NEUPHARMA, INC.

US Patent


Assay Description
The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...


US Patent US10172868 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%