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Patent code US10173996

Compile Data Set for Download or QSAR

Found 511 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM264046
PNG
(2-[5-[(2-fluoro-4- methylphenyl)methoxy]pyrazol-1-...)
Show SMILES Cc1ccc(COc2ccnn2-c2cc(ccn2)C(O)=O)c(F)c1
Show InChI InChI=1S/C17H14FN3O3/c1-11-2-3-13(14(18)8-11)10-24-16-5-7-20-21(16)15-9-12(17(22)23)4-6-19-15/h2-9H,10H2,1H3,(H,22,23)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US10173996 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM264054
PNG
(2-[5-[[4-fluoro-3-[(4- fluorophenyl)methoxy]phenyl...)
Show SMILES OC(=O)c1ccnc(c1)-n1nccc1OCc1ccc(F)c(OCc2ccc(F)cc2)c1
Show InChI InChI=1S/C23H17F2N3O4/c24-18-4-1-15(2-5-18)13-31-20-11-16(3-6-19(20)25)14-32-22-8-10-27-28(22)21-12-17(23(29)30)7-9-26-21/h1-12H,13-14H2,(H,29,30)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US10173996 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM264000
PNG
(2-{5-[(4-chloro-3- fluorobenzyl)oxy]-1H-pyrazol-1-...)
Show SMILES OC(=O)c1ccnc(c1)-n1nccc1OCc1ccc(Cl)c(F)c1
Show InChI InChI=1S/C16H11ClFN3O3/c17-12-2-1-10(7-13(12)18)9-24-15-4-6-20-21(15)14-8-11(16(22)23)3-5-19-14/h1-8H,9H2,(H,22,23)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US10173996 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM264002
PNG
(2-{5-[(3-chloro-4- fluorobenzyl)oxy]-1H-pyrazol-1-...)
Show SMILES OC(=O)c1ccnc(c1)-n1nccc1OCc1ccc(F)c(Cl)c1
Show InChI InChI=1S/C16H11ClFN3O3/c17-12-7-10(1-2-13(12)18)9-24-15-4-6-20-21(15)14-8-11(16(22)23)3-5-19-14/h1-8H,9H2,(H,22,23)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US10173996 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM264003
PNG
(2-{5-[(4-cyclopropylbenzyl)oxy]- 1H-pyrazol-1-yl}p...)
Show SMILES OC(=O)c1ccnc(c1)-n1nccc1OCc1ccc(cc1)C1CC1
Show InChI InChI=1S/C19H17N3O3/c23-19(24)16-7-9-20-17(11-16)22-18(8-10-21-22)25-12-13-1-3-14(4-2-13)15-5-6-15/h1-4,7-11,15H,5-6,12H2,(H,23,24)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US10173996 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM264008
PNG
(2-[5-[(2,4- difluorophenyl)methoxy]pyrazol- 1-yl]p...)
Show SMILES OC(=O)c1ccnc(c1)-n1nccc1OCc1ccc(F)cc1F
Show InChI InChI=1S/C16H11F2N3O3/c17-12-2-1-11(13(18)8-12)9-24-15-4-6-20-21(15)14-7-10(16(22)23)3-5-19-14/h1-8H,9H2,(H,22,23)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US10173996 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM264010
PNG
(2-[5-[(2,4- dichlorophenyl)methoxy]pyrazol- 1-yl]p...)
Show SMILES OC(=O)c1ccnc(c1)-n1nccc1OCc1ccc(Cl)cc1Cl
Show InChI InChI=1S/C16H11Cl2N3O3/c17-12-2-1-11(13(18)8-12)9-24-15-4-6-20-21(15)14-7-10(16(22)23)3-5-19-14/h1-8H,9H2,(H,22,23)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US10173996 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM264014
PNG
(2-[5-[(3-chloro-4- methylphenyl)methoxy]pyrazol-1-...)
Show SMILES Cc1ccc(COc2ccnn2-c2cc(ccn2)C(O)=O)cc1Cl
Show InChI InChI=1S/C17H14ClN3O3/c1-11-2-3-12(8-14(11)18)10-24-16-5-7-20-21(16)15-9-13(17(22)23)4-6-19-15/h2-9H,10H2,1H3,(H,22,23)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US10173996 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM312329
PNG
(2-[5-[(3-fluoro-4- methylphenyl)methoxy]pyrazol-1-...)
Show SMILES Cc1ccc(COc2ccnn2-c2cc(ccn2)C(O)=O)cc1F
Show InChI InChI=1S/C17H14FN3O3/c1-11-2-3-12(8-14(11)18)10-24-16-5-7-20-21(16)15-9-13(17(22)23)4-6-19-15/h2-9H,10H2,1H3,(H,22,23)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US10173996 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM312329
PNG
(2-[5-[(3-fluoro-4- methylphenyl)methoxy]pyrazol-1-...)
Show SMILES Cc1ccc(COc2ccnn2-c2cc(ccn2)C(O)=O)cc1F
Show InChI InChI=1S/C17H14FN3O3/c1-11-2-3-12(8-14(11)18)10-24-16-5-7-20-21(16)15-9-13(17(22)23)4-6-19-15/h2-9H,10H2,1H3,(H,22,23)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US10173996 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM264016
PNG
(2-[5-[(2,3-difluoro-4- methylphenyl)methoxy]pyrazo...)
Show SMILES Cc1ccc(COc2ccnn2-c2cc(ccn2)C(O)=O)c(F)c1F
Show InChI InChI=1S/C17H13F2N3O3/c1-10-2-3-12(16(19)15(10)18)9-25-14-5-7-21-22(14)13-8-11(17(23)24)4-6-20-13/h2-8H,9H2,1H3,(H,23,24)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US10173996 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM264017
PNG
(2-[5-[(3-chloro-4- ethylphenyl)methoxy]pyrazol-1- ...)
Show SMILES CCc1ccc(COc2ccnn2-c2cc(ccn2)C(O)=O)cc1Cl
Show InChI InChI=1S/C18H16ClN3O3/c1-2-13-4-3-12(9-15(13)19)11-25-17-6-8-21-22(17)16-10-14(18(23)24)5-7-20-16/h3-10H,2,11H2,1H3,(H,23,24)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US10173996 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM264019
PNG
(2-[5-[(3- cyanophenyl)methoxy]pyrazol-1- yl]pyridi...)
Show SMILES OC(=O)c1ccnc(c1)-n1nccc1OCc1cccc(c1)C#N
Show InChI InChI=1S/C17H12N4O3/c18-10-12-2-1-3-13(8-12)11-24-16-5-7-20-21(16)15-9-14(17(22)23)4-6-19-15/h1-9H,11H2,(H,22,23)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US10173996 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM264020
PNG
(2-[5-[(4- cyanophenyl)methoxy]pyrazol-1- yl]pyridi...)
Show SMILES OC(=O)c1ccnc(c1)-n1nccc1OCc1ccc(cc1)C#N
Show InChI InChI=1S/C17H12N4O3/c18-10-12-1-3-13(4-2-12)11-24-16-6-8-20-21(16)15-9-14(17(22)23)5-7-19-15/h1-9H,11H2,(H,22,23)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US10173996 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM264022
PNG
(2-[5-[[4-chloro-2- (cyclopropylmethoxy(phenyl] met...)
Show SMILES OC(=O)c1ccnc(c1)-n1nccc1OCc1ccc(Cl)cc1OCC1CC1
Show InChI InChI=1S/C20H18ClN3O4/c21-16-4-3-15(17(10-16)27-11-13-1-2-13)12-28-19-6-8-23-24(19)18-9-14(20(25)26)5-7-22-18/h3-10,13H,1-2,11-12H2,(H,25,26)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US10173996 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM264023
PNG
(2-[5-[[4-chloro-2-(2,2,2- trifluoroethoxy)phenyl]m...)
Show SMILES OC(=O)c1ccnc(c1)-n1nccc1OCc1ccc(Cl)cc1OCC(F)(F)F
Show InChI InChI=1S/C18H13ClF3N3O4/c19-13-2-1-12(14(8-13)29-10-18(20,21)22)9-28-16-4-6-24-25(16)15-7-11(17(26)27)3-5-23-15/h1-8H,9-10H2,(H,26,27)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US10173996 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM264046
PNG
(2-[5-[(2-fluoro-4- methylphenyl)methoxy]pyrazol-1-...)
Show SMILES Cc1ccc(COc2ccnn2-c2cc(ccn2)C(O)=O)c(F)c1
Show InChI InChI=1S/C17H14FN3O3/c1-11-2-3-13(14(18)8-11)10-24-16-5-7-20-21(16)15-9-12(17(22)23)4-6-19-15/h2-9H,10H2,1H3,(H,22,23)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US10173996 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM264048
PNG
(2-[5-[(2-methoxy-4- methylphenyl)methoxy]pyrazol-1...)
Show SMILES COc1cc(C)ccc1COc1ccnn1-c1cc(ccn1)C(O)=O
Show InChI InChI=1S/C18H17N3O4/c1-12-3-4-14(15(9-12)24-2)11-25-17-6-8-20-21(17)16-10-13(18(22)23)5-7-19-16/h3-10H,11H2,1-2H3,(H,22,23)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US10173996 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM264056
PNG
(2-[5-[[4-chloro-3-(2,2,2- trifluoroethoxy)phenyl]m...)
Show SMILES OC(=O)c1ccnc(c1)-n1nccc1OCc1ccc(Cl)c(OCC(F)(F)F)c1
Show InChI InChI=1S/C18H13ClF3N3O4/c19-13-2-1-11(7-14(13)29-10-18(20,21)22)9-28-16-4-6-24-25(16)15-8-12(17(26)27)3-5-23-15/h1-8H,9-10H2,(H,26,27)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US10173996 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM264059
PNG
(2-[5-[(4-iodo-2- methylphenyl)methoxy]pyrazol- 1-y...)
Show SMILES Cc1cc(I)ccc1COc1ccnn1-c1cc(ccn1)C(O)=O
Show InChI InChI=1S/C17H14IN3O3/c1-11-8-14(18)3-2-13(11)10-24-16-5-7-20-21(16)15-9-12(17(22)23)4-6-19-15/h2-9H,10H2,1H3,(H,22,23)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US10173996 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM264072
PNG
(N-cyano-2-[4-[2-[(4- fluorophenyl)methyl- methylam...)
Show SMILES CN(CCc1cnn(c1)-c1cc(ccn1)C(=O)N[N+]#[C-])Cc1ccc(F)cc1
Show InChI InChI=1S/C20H19FN6O/c1-22-25-20(28)17-7-9-23-19(11-17)27-14-16(12-24-27)8-10-26(2)13-15-3-5-18(21)6-4-15/h3-7,9,11-12,14H,8,10,13H2,2H3,(H,25,28)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10173996 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (human))
BDBM264074
PNG
(2-[3-(3-chlorophenyl)-5- hydroxypyrazol-1-yl]pyrid...)
Show SMILES OC(=O)c1ccnc(c1)-n1nc(cc1O)-c1cccc(Cl)c1
Show InChI InChI=1S/C15H10ClN3O3/c16-11-3-1-2-9(6-11)12-8-14(20)19(18-12)13-7-10(15(21)22)4-5-17-13/h1-8,20H,(H,21,22)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10173996 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (human))
BDBM264082
PNG
(5-[(2-chlorophenyl)methyl]-2-[4- (1H-tetrazol-5-yl...)
Show SMILES Oc1cc(Cc2ccccc2Cl)nn1-c1cc(ccn1)-c1nn[nH]n1
Show InChI InChI=1S/C16H12ClN7O/c17-13-4-2-1-3-10(13)7-12-9-15(25)24(21-12)14-8-11(5-6-18-14)16-19-22-23-20-16/h1-6,8-9,25H,7H2,(H,19,20,22,23)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10173996 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (human))
BDBM264090
PNG
(2-[3-[(2,4-difluorophenyl)methyl]- 5-hydroxypyrazo...)
Show SMILES OC(=O)c1ccnc(c1)-n1nc(Cc2ccc(F)cc2F)cc1O
Show InChI InChI=1S/C16H11F2N3O3/c17-11-2-1-9(13(18)7-11)5-12-8-15(22)21(20-12)14-6-10(16(23)24)3-4-19-14/h1-4,6-8,22H,5H2,(H,23,24)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10173996 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM263924
PNG
(2-(5-hydroxy-3-methyl-1H- pyrazol-1-yl)isonicotini...)
Show SMILES Cc1cc(O)n(n1)-c1cc(ccn1)C(O)=O
Show InChI InChI=1S/C10H9N3O3/c1-6-4-9(14)13(12-6)8-5-7(10(15)16)2-3-11-8/h2-5,14H,1H3,(H,15,16)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US10173996 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM263941
PNG
(2-(5-hydroxy-1H-pyrazol-1- yl)isonicotinic acid | ...)
Show SMILES OC(=O)c1ccnc(c1)-n1nccc1O
Show InChI InChI=1S/C9H7N3O3/c13-8-2-4-11-12(8)7-5-6(9(14)15)1-3-10-7/h1-5,13H,(H,14,15)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US10173996 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM263977
PNG
(2-{5-[(3-methoxybenzyl)oxy]-1H- pyrazol-1-yl}pyrid...)
Show SMILES COc1cccc(COc2ccnn2-c2cc(ccn2)C(O)=O)c1
Show InChI InChI=1S/C17H15N3O4/c1-23-14-4-2-3-12(9-14)11-24-16-6-8-19-20(16)15-10-13(17(21)22)5-7-18-15/h2-10H,11H2,1H3,(H,21,22)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US10173996 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM263983
PNG
(2-[3-amino-5-(4-methylphenyl)- 1H-pyrazol-1-yl]pyr...)
Show SMILES Cc1ccc(cc1)-c1cc(N)nn1-c1cc(ccn1)C(O)=O
Show InChI InChI=1S/C16H14N4O2/c1-10-2-4-11(5-3-10)13-9-14(17)19-20(13)15-8-12(16(21)22)6-7-18-15/h2-9H,1H3,(H2,17,19)(H,21,22)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US10173996 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM319599
PNG
(2-{5-[(1-methyl-1H-indazol-6- yl)methoxy]-1H-pyraz...)
Show SMILES C[N]1=CC2C=CC(COc3ccnn3-c3cc(ccn3)C(O)=O)=CC2=N1
Show InChI InChI=1S/C18H16N5O3/c1-22-10-14-3-2-12(8-15(14)21-22)11-26-17-5-7-20-23(17)16-9-13(18(24)25)4-6-19-16/h2-10,14H,11H2,1H3,(H,24,25)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US10173996 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM263989
PNG
(2-(5-{[4- (trifluoromethyl)benzyl]oxy}- 1H-pyrazol...)
Show SMILES OC(=O)c1ccnc(c1)-n1nccc1OCc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C17H12F3N3O3/c18-17(19,20)13-3-1-11(2-4-13)10-26-15-6-8-22-23(15)14-9-12(16(24)25)5-7-21-14/h1-9H,10H2,(H,24,25)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US10173996 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM263992
PNG
(2-{5-[(4-bromobenzyl)oxy]-1H- pyrazol-1-yl}pyridin...)
Show SMILES OC(=O)c1ccnc(c1)-n1nccc1OCc1ccc(Br)cc1
Show InChI InChI=1S/C16H12BrN3O3/c17-13-3-1-11(2-4-13)10-23-15-6-8-19-20(15)14-9-12(16(21)22)5-7-18-14/h1-9H,10H2,(H,21,22)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US10173996 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM263998
PNG
(2-{5-[(3-bromobenzyl)oxy]-1H- pyrazol-1-yl}pyridin...)
Show SMILES OC(=O)c1ccnc(c1)-n1nccc1OCc1cccc(Br)c1
Show InChI InChI=1S/C16H12BrN3O3/c17-13-3-1-2-11(8-13)10-23-15-5-7-19-20(15)14-9-12(16(21)22)4-6-18-14/h1-9H,10H2,(H,21,22)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US10173996 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM264000
PNG
(2-{5-[(4-chloro-3- fluorobenzyl)oxy]-1H-pyrazol-1-...)
Show SMILES OC(=O)c1ccnc(c1)-n1nccc1OCc1ccc(Cl)c(F)c1
Show InChI InChI=1S/C16H11ClFN3O3/c17-12-2-1-10(7-13(12)18)9-24-15-4-6-20-21(15)14-8-11(16(22)23)3-5-19-14/h1-8H,9H2,(H,22,23)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10173996 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM264002
PNG
(2-{5-[(3-chloro-4- fluorobenzyl)oxy]-1H-pyrazol-1-...)
Show SMILES OC(=O)c1ccnc(c1)-n1nccc1OCc1ccc(F)c(Cl)c1
Show InChI InChI=1S/C16H11ClFN3O3/c17-12-7-10(1-2-13(12)18)9-24-15-4-6-20-21(15)14-8-11(16(22)23)3-5-19-14/h1-8H,9H2,(H,22,23)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10173996 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM264004
PNG
(2-[5-[1-(4- fluorophenyl)ethoxy]pyrazol-1- yl]pyri...)
Show SMILES CC(Oc1ccnn1-c1cc(ccn1)C(O)=O)c1ccc(F)cc1
Show InChI InChI=1S/C17H14FN3O3/c1-11(12-2-4-14(18)5-3-12)24-16-7-9-20-21(16)15-10-13(17(22)23)6-8-19-15/h2-11H,1H3,(H,22,23)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US10173996 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM191600
PNG
(2-(5-((4-chloro-2-methylbenzyl)oxy)-1Hpyrazol-1-yl...)
Show SMILES Cc1cc(Cl)ccc1COc1ccnn1-c1cc(ccn1)C(O)=O
Show InChI InChI=1S/C17H14ClN3O3/c1-11-8-14(18)3-2-13(11)10-24-16-5-7-20-21(16)15-9-12(17(22)23)4-6-19-15/h2-9H,10H2,1H3,(H,22,23)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US10173996 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM264012
PNG
(2-[5-[(4-chloro-2- methoxyphenyl)methoxy]pyrazol- ...)
Show SMILES COc1cc(Cl)ccc1COc1ccnn1-c1cc(ccn1)C(O)=O
Show InChI InChI=1S/C17H14ClN3O4/c1-24-14-9-13(18)3-2-12(14)10-25-16-5-7-20-21(16)15-8-11(17(22)23)4-6-19-15/h2-9H,10H2,1H3,(H,22,23)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US10173996 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM264018
PNG
(2-[5-[(4-ethyl-3- fluorophenyl)methoxy]pyrazol-1- ...)
Show SMILES CCc1ccc(COc2ccnn2-c2cc(ccn2)C(O)=O)cc1F
Show InChI InChI=1S/C18H16FN3O3/c1-2-13-4-3-12(9-15(13)19)11-25-17-6-8-21-22(17)16-10-14(18(23)24)5-7-20-16/h3-10H,2,11H2,1H3,(H,23,24)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US10173996 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM264038
PNG
(2-[5-(2,3-dihydro-1-benzofuran-7- ylmethoxy)pyrazo...)
Show SMILES OC(=O)c1ccnc(c1)-n1nccc1OCc1cccc2CCOc12
Show InChI InChI=1S/C18H15N3O4/c22-18(23)13-4-7-19-15(10-13)21-16(5-8-20-21)25-11-14-3-1-2-12-6-9-24-17(12)14/h1-5,7-8,10H,6,9,11H2,(H,22,23)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US10173996 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM264039
PNG
(2-[5-[(2,2-dimethyl-3H-1- benzofuran-7-yl)methoxy]...)
Show SMILES CC1(C)Cc2cccc(COc3ccnn3-c3cc(ccn3)C(O)=O)c2O1
Show InChI InChI=1S/C20H19N3O4/c1-20(2)11-14-4-3-5-15(18(14)27-20)12-26-17-7-9-22-23(17)16-10-13(19(24)25)6-8-21-16/h3-10H,11-12H2,1-2H3,(H,24,25)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US10173996 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM264040
PNG
(2-[5-[(4-cyano-2- methylphenyl)methoxy]pyrazol-1- ...)
Show SMILES Cc1cc(ccc1COc1ccnn1-c1cc(ccn1)C(O)=O)C#N
Show InChI InChI=1S/C18H14N4O3/c1-12-8-13(10-19)2-3-15(12)11-25-17-5-7-21-22(17)16-9-14(18(23)24)4-6-20-16/h2-9H,11H2,1H3,(H,23,24)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US10173996 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM264041
PNG
(2-[5-[(4-cyano-2- ethylphenyl)methoxy]pyrazol-1- y...)
Show SMILES CCc1cc(ccc1COc1ccnn1-c1cc(ccn1)C(O)=O)C#N
Show InChI InChI=1S/C19H16N4O3/c1-2-14-9-13(11-20)3-4-16(14)12-26-18-6-8-22-23(18)17-10-15(19(24)25)5-7-21-17/h3-10H,2,12H2,1H3,(H,24,25)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US10173996 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM264043
PNG
(2-[5-[(4-fluoro-2- methylphenyl)methoxy]pyrazol-1-...)
Show SMILES Cc1cc(F)ccc1COc1ccnn1-c1cc(ccn1)C(O)=O
Show InChI InChI=1S/C17H14FN3O3/c1-11-8-14(18)3-2-13(11)10-24-16-5-7-20-21(16)15-9-12(17(22)23)4-6-19-15/h2-9H,10H2,1H3,(H,22,23)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US10173996 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM264044
PNG
(2-[5-[(2-ethyl-4- fluorophenyl)methoxy]pyrazol-1- ...)
Show SMILES CCc1cc(F)ccc1COc1ccnn1-c1cc(ccn1)C(O)=O
Show InChI InChI=1S/C18H16FN3O3/c1-2-12-9-15(19)4-3-14(12)11-25-17-6-8-21-22(17)16-10-13(18(23)24)5-7-20-16/h3-10H,2,11H2,1H3,(H,23,24)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US10173996 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM264054
PNG
(2-[5-[[4-fluoro-3-[(4- fluorophenyl)methoxy]phenyl...)
Show SMILES OC(=O)c1ccnc(c1)-n1nccc1OCc1ccc(F)c(OCc2ccc(F)cc2)c1
Show InChI InChI=1S/C23H17F2N3O4/c24-18-4-1-15(2-5-18)13-31-20-11-16(3-6-19(20)25)14-32-22-8-10-27-28(22)21-12-17(23(29)30)7-9-26-21/h1-12H,13-14H2,(H,29,30)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US10173996 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM264060
PNG
(2-[5-[(4-iodo-2- methoxyphenyl)methoxy]pyrazol- 1-...)
Show SMILES COc1cc(I)ccc1COc1ccnn1-c1cc(ccn1)C(O)=O
Show InChI InChI=1S/C17H14IN3O4/c1-24-14-9-13(18)3-2-12(14)10-25-16-5-7-20-21(16)15-8-11(17(22)23)4-6-19-15/h2-9H,10H2,1H3,(H,22,23)
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n/an/a<100n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US10173996 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM264072
PNG
(N-cyano-2-[4-[2-[(4- fluorophenyl)methyl- methylam...)
Show SMILES CN(CCc1cnn(c1)-c1cc(ccn1)C(=O)N[N+]#[C-])Cc1ccc(F)cc1
Show InChI InChI=1S/C20H19FN6O/c1-22-25-20(28)17-7-9-23-19(11-17)27-14-16(12-24-27)8-10-26(2)13-15-3-5-18(21)6-4-15/h3-7,9,11-12,14H,8,10,13H2,2H3,(H,25,28)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US10173996 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM264072
PNG
(N-cyano-2-[4-[2-[(4- fluorophenyl)methyl- methylam...)
Show SMILES CN(CCc1cnn(c1)-c1cc(ccn1)C(=O)N[N+]#[C-])Cc1ccc(F)cc1
Show InChI InChI=1S/C20H19FN6O/c1-22-25-20(28)17-7-9-23-19(11-17)27-14-16(12-24-27)8-10-26(2)13-15-3-5-18(21)6-4-15/h3-7,9,11-12,14H,8,10,13H2,2H3,(H,25,28)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US10173996 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (human))
BDBM264079
PNG
(2-[3-[(3-chlorophenyl)methyl]-5- hydroxypyrazol-1-...)
Show SMILES OC(=O)c1ccnc(c1)-n1nc(Cc2cccc(Cl)c2)cc1O
Show InChI InChI=1S/C16H12ClN3O3/c17-12-3-1-2-10(6-12)7-13-9-15(21)20(19-13)14-8-11(16(22)23)4-5-18-14/h1-6,8-9,21H,7H2,(H,22,23)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10173996 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (human))
BDBM264084
PNG
(5-[(4-chlorophenyl)methyl]-2-[4- (1H-tetrazol-5-yl...)
Show SMILES Oc1cc(Cc2ccc(Cl)cc2)nn1-c1cc(ccn1)-c1nn[nH]n1
Show InChI InChI=1S/C16H12ClN7O/c17-12-3-1-10(2-4-12)7-13-9-15(25)24(21-13)14-8-11(5-6-18-14)16-19-22-23-20-16/h1-6,8-9,25H,7H2,(H,19,20,22,23)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10173996 (2019)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%