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Patent code US10174000

Compile Data Set for Download or QSAR
Found 62 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM319575
PNG
(5-(((2S,3S,4S)-3-ethyl-4-fluoro-5-oxopyrrolidin-2-...)
Show SMILES CC[C@H]1[C@@H](COc2cccc3cc(C(N)=O)c(OC)cc23)NC(=O)[C@H]1F
Show InChI InChI=1S/C19H21FN2O4/c1-3-11-14(22-19(24)17(11)20)9-26-15-6-4-5-10-7-13(18(21)23)16(25-2)8-12(10)15/h4-8,11,14,17H,3,9H2,1-2H3,(H2,21,23)(H,22,24)/t11-,14+,17-/m0/s1
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Pfizer Inc.

US Patent


Assay Description
This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...


US Patent US10174000 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM319574
PNG
(4-(((2S,3S,4S)-3-ethyl-4-fluoro-5-oxopyrrolidin-2-...)
Show SMILES CC[C@H]1[C@@H](COc2cncc3cc(C(N)=O)c(OC)cc23)NC(=O)[C@H]1F
Show InChI InChI=1S/C18H20FN3O4/c1-3-10-13(22-18(24)16(10)19)8-26-15-7-21-6-9-4-12(17(20)23)14(25-2)5-11(9)15/h4-7,10,13,16H,3,8H2,1-2H3,(H2,20,23)(H,22,24)/t10-,13+,16-/m0/s1
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Pfizer Inc.

US Patent


Assay Description
This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...


US Patent US10174000 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM319564
PNG
(4-Amino-1-{[(2S,3S,4S)-3-ethyl-4-fluoro-5-oxopyrro...)
Show SMILES CC[C@H]1[C@@H](COc2ncc(N)c3cc(C(N)=O)c(OC)cc23)NC(=O)[C@H]1F
Show InChI InChI=1S/C18H21FN4O4/c1-3-8-13(23-17(25)15(8)19)7-27-18-10-5-14(26-2)11(16(21)24)4-9(10)12(20)6-22-18/h4-6,8,13,15H,3,7,20H2,1-2H3,(H2,21,24)(H,23,25)/t8-,13+,15-/m0/s1
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Pfizer Inc.

US Patent


Assay Description
This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...


US Patent US10174000 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM319568
PNG
(1-(((4S,7S)-7-fluoro-6-oxo-5-azaspiro[2.4]heptan-4...)
Show SMILES CC(C)Oc1cc2c(OC[C@H]3NC(=O)[C@@H](F)C33CC3)nccc2cc1C(N)=O
Show InChI InChI=1S/C20H22FN3O4/c1-10(2)28-14-8-12-11(7-13(14)17(22)25)3-6-23-19(12)27-9-15-20(4-5-20)16(21)18(26)24-15/h3,6-8,10,15-16H,4-5,9H2,1-2H3,(H2,22,25)(H,24,26)/t15-,16-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...


US Patent US10174000 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM319572
PNG
(1-(((4S,7S)-7-fluoro-6-oxo-5-azaspiro[2.4]heptan-4...)
Show SMILES COc1cc2c(OC[C@H]3NC(=O)[C@@H](F)C33CC3)nccc2cc1C(N)=O
Show InChI InChI=1S/C18H18FN3O4/c1-25-12-7-10-9(6-11(12)15(20)23)2-5-21-17(10)26-8-13-18(3-4-18)14(19)16(24)22-13/h2,5-7,13-14H,3-4,8H2,1H3,(H2,20,23)(H,22,24)/t13-,14-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...


US Patent US10174000 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM319575
PNG
(5-(((2S,3S,4S)-3-ethyl-4-fluoro-5-oxopyrrolidin-2-...)
Show SMILES CC[C@H]1[C@@H](COc2cccc3cc(C(N)=O)c(OC)cc23)NC(=O)[C@H]1F
Show InChI InChI=1S/C19H21FN2O4/c1-3-11-14(22-19(24)17(11)20)9-26-15-6-4-5-10-7-13(18(21)23)16(25-2)8-12(10)15/h4-8,11,14,17H,3,9H2,1-2H3,(H2,21,23)(H,22,24)/t11-,14+,17-/m0/s1
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Pfizer Inc.

US Patent


Assay Description
This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...


US Patent US10174000 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM319554
PNG
(4-(1-methyl-1H-pyrazol-4-yl)-1-{[(2S)-5-oxopyrroli...)
Show SMILES CC(C)Oc1cc2c(OC[C@@H]3CCC(=O)N3)ncc(-c3cnn(C)c3)c2cc1C(N)=O
Show InChI InChI=1S/C22H25N5O4/c1-12(2)31-19-7-16-15(6-17(19)21(23)29)18(13-8-25-27(3)10-13)9-24-22(16)30-11-14-4-5-20(28)26-14/h6-10,12,14H,4-5,11H2,1-3H3,(H2,23,29)(H,26,28)/t14-/m0/s1
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Pfizer Inc.

US Patent


Assay Description
This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...


US Patent US10174000 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM319566
PNG
(1-(((4S,7R)-7-fluoro-6-oxo-5-azaspiro[2.4]heptan-4...)
Show SMILES CC(C)Oc1cc2c(OC[C@H]3NC(=O)[C@H](F)C33CC3)nccc2cc1C(N)=O
Show InChI InChI=1S/C20H22FN3O4/c1-10(2)28-14-8-12-11(7-13(14)17(22)25)3-6-23-19(12)27-9-15-20(4-5-20)16(21)18(26)24-15/h3,6-8,10,15-16H,4-5,9H2,1-2H3,(H2,22,25)(H,24,26)/t15-,16+/m1/s1
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Pfizer Inc.

US Patent


Assay Description
This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...


US Patent US10174000 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM319550
PNG
(8-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-...)
Show SMILES CC[C@H]1[C@@H](COc2cccc3cc(C(N)=O)c(OC)nc23)NC(=O)[C@H]1F
Show InChI InChI=1S/C18H20FN3O4/c1-3-10-12(21-17(24)14(10)19)8-26-13-6-4-5-9-7-11(16(20)23)18(25-2)22-15(9)13/h4-7,10,12,14H,3,8H2,1-2H3,(H2,20,23)(H,21,24)/t10-,12+,14-/m0/s1
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Pfizer Inc.

US Patent


Assay Description
This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...


US Patent US10174000 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM319564
PNG
(4-Amino-1-{[(2S,3S,4S)-3-ethyl-4-fluoro-5-oxopyrro...)
Show SMILES CC[C@H]1[C@@H](COc2ncc(N)c3cc(C(N)=O)c(OC)cc23)NC(=O)[C@H]1F
Show InChI InChI=1S/C18H21FN4O4/c1-3-8-13(23-17(25)15(8)19)7-27-18-10-5-14(26-2)11(16(21)24)4-9(10)12(20)6-22-18/h4-6,8,13,15H,3,7,20H2,1-2H3,(H2,21,24)(H,23,25)/t8-,13+,15-/m0/s1
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Pfizer Inc.

US Patent


Assay Description
This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...


US Patent US10174000 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM319573
PNG
(4-(((2S,3R)-3-ethyl-5-oxopyrrolidin-2-yl)methoxy)-...)
Show SMILES CC[C@@H]1CC(=O)N[C@@H]1COc1cncc2cc(C(N)=O)c(OC)cc12
Show InChI InChI=1S/C18H21N3O4/c1-3-10-5-17(22)21-14(10)9-25-16-8-20-7-11-4-13(18(19)23)15(24-2)6-12(11)16/h4,6-8,10,14H,3,5,9H2,1-2H3,(H2,19,23)(H,21,22)/t10-,14-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...


US Patent US10174000 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM319555
PNG
(4-(4-Methyl-1,3-oxazol-2-yl)-1-{[(2S)-5-oxopyrroli...)
Show SMILES CC(C)Oc1cc2c(OC[C@@H]3CCC(=O)N3)ncc(-c3nc(C)co3)c2cc1C(N)=O
Show InChI InChI=1S/C22H24N4O5/c1-11(2)31-18-7-15-14(6-16(18)20(23)28)17(22-25-12(3)9-29-22)8-24-21(15)30-10-13-4-5-19(27)26-13/h6-9,11,13H,4-5,10H2,1-3H3,(H2,23,28)(H,26,27)/t13-/m0/s1
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Pfizer Inc.

US Patent


Assay Description
This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...


US Patent US10174000 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM319556
PNG
(4-(4,5-Dimethyl-1,3-oxazol-2-yl)-1-{[(2S)-5-oxopyr...)
Show SMILES CC(C)Oc1cc2c(OC[C@@H]3CCC(=O)N3)ncc(-c3nc(C)c(C)o3)c2cc1C(N)=O
Show InChI InChI=1S/C23H26N4O5/c1-11(2)31-19-8-16-15(7-17(19)21(24)29)18(23-26-12(3)13(4)32-23)9-25-22(16)30-10-14-5-6-20(28)27-14/h7-9,11,14H,5-6,10H2,1-4H3,(H2,24,29)(H,27,28)/t14-/m0/s1
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Pfizer Inc.

US Patent


Assay Description
This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...


US Patent US10174000 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM319554
PNG
(4-(1-methyl-1H-pyrazol-4-yl)-1-{[(2S)-5-oxopyrroli...)
Show SMILES CC(C)Oc1cc2c(OC[C@@H]3CCC(=O)N3)ncc(-c3cnn(C)c3)c2cc1C(N)=O
Show InChI InChI=1S/C22H25N5O4/c1-12(2)31-19-7-16-15(6-17(19)21(23)29)18(13-8-25-27(3)10-13)9-24-22(16)30-11-14-4-5-20(28)26-14/h6-10,12,14H,4-5,11H2,1-3H3,(H2,23,29)(H,26,28)/t14-/m0/s1
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Pfizer Inc.

US Patent


Assay Description
This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...


US Patent US10174000 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM319551
PNG
(4-(1,3-Oxazol-2-yl)-1-{[(2S)-5-oxopyrrolidin-2-yl]...)
Show SMILES CC(C)Oc1cc2c(OC[C@@H]3CCC(=O)N3)ncc(-c3ncco3)c2cc1C(N)=O
Show InChI InChI=1S/C21H22N4O5/c1-11(2)30-17-8-14-13(7-15(17)19(22)27)16(21-23-5-6-28-21)9-24-20(14)29-10-12-3-4-18(26)25-12/h5-9,11-12H,3-4,10H2,1-2H3,(H2,22,27)(H,25,26)/t12-/m0/s1
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Pfizer Inc.

US Patent


Assay Description
This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...


US Patent US10174000 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM319558
PNG
(4-(5-Methyl-1,3-oxazol-2-yl)-1-{[(2S)-5-oxopyrroli...)
Show SMILES CC(C)Oc1cc2c(OC[C@@H]3CCC(=O)N3)ncc(-c3ncc(C)o3)c2cc1C(N)=O
Show InChI InChI=1S/C22H24N4O5/c1-11(2)30-18-7-15-14(6-16(18)20(23)28)17(22-24-8-12(3)31-22)9-25-21(15)29-10-13-4-5-19(27)26-13/h6-9,11,13H,4-5,10H2,1-3H3,(H2,23,28)(H,26,27)/t13-/m0/s1
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Pfizer Inc.

US Patent


Assay Description
This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...


US Patent US10174000 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM319580
PNG
(5-{[(2S,3S,4S)-3-ethyl-4-fluoro-5-oxopyrrolidin-2-...)
Show SMILES CC[C@H]1[C@@H](COc2nccc3nc(C(N)=O)c(OC)cc23)NC(=O)[C@H]1F
Show InChI InChI=1S/C17H19FN4O4/c1-3-8-11(22-16(24)13(8)18)7-26-17-9-6-12(25-2)14(15(19)23)21-10(9)4-5-20-17/h4-6,8,11,13H,3,7H2,1-2H3,(H2,19,23)(H,22,24)/t8-,11+,13-/m0/s1
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Pfizer Inc.

US Patent


Assay Description
This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...


US Patent US10174000 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM319572
PNG
(1-(((4S,7S)-7-fluoro-6-oxo-5-azaspiro[2.4]heptan-4...)
Show SMILES COc1cc2c(OC[C@H]3NC(=O)[C@@H](F)C33CC3)nccc2cc1C(N)=O
Show InChI InChI=1S/C18H18FN3O4/c1-25-12-7-10-9(6-11(12)15(20)23)2-5-21-17(10)26-8-13-18(3-4-18)14(19)16(24)22-13/h2,5-7,13-14H,3-4,8H2,1H3,(H2,20,23)(H,22,24)/t13-,14-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...


US Patent US10174000 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM319568
PNG
(1-(((4S,7S)-7-fluoro-6-oxo-5-azaspiro[2.4]heptan-4...)
Show SMILES CC(C)Oc1cc2c(OC[C@H]3NC(=O)[C@@H](F)C33CC3)nccc2cc1C(N)=O
Show InChI InChI=1S/C20H22FN3O4/c1-10(2)28-14-8-12-11(7-13(14)17(22)25)3-6-23-19(12)27-9-15-20(4-5-20)16(21)18(26)24-15/h3,6-8,10,15-16H,4-5,9H2,1-2H3,(H2,22,25)(H,24,26)/t15-,16-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...


US Patent US10174000 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM319550
PNG
(8-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-...)
Show SMILES CC[C@H]1[C@@H](COc2cccc3cc(C(N)=O)c(OC)nc23)NC(=O)[C@H]1F
Show InChI InChI=1S/C18H20FN3O4/c1-3-10-12(21-17(24)14(10)19)8-26-13-6-4-5-9-7-11(16(20)23)18(25-2)22-15(9)13/h4-7,10,12,14H,3,8H2,1-2H3,(H2,20,23)(H,21,24)/t10-,12+,14-/m0/s1
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Pfizer Inc.

US Patent


Assay Description
This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...


US Patent US10174000 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM319574
PNG
(4-(((2S,3S,4S)-3-ethyl-4-fluoro-5-oxopyrrolidin-2-...)
Show SMILES CC[C@H]1[C@@H](COc2cncc3cc(C(N)=O)c(OC)cc23)NC(=O)[C@H]1F
Show InChI InChI=1S/C18H20FN3O4/c1-3-10-13(22-18(24)16(10)19)8-26-15-7-21-6-9-4-12(17(20)23)14(25-2)5-11(9)15/h4-7,10,13,16H,3,8H2,1-2H3,(H2,20,23)(H,22,24)/t10-,13+,16-/m0/s1
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Pfizer Inc.

US Patent


Assay Description
This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...


US Patent US10174000 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM319553
PNG
(4-(1-Methyl-1H-pyrazol-3-yl)-1-{[(2S)-5-oxopyrroli...)
Show SMILES CC(C)Oc1cc2c(OC[C@@H]3CCC(=O)N3)ncc(-c3ccn(C)n3)c2cc1C(N)=O
Show InChI InChI=1S/C22H25N5O4/c1-12(2)31-19-9-15-14(8-16(19)21(23)29)17(18-6-7-27(3)26-18)10-24-22(15)30-11-13-4-5-20(28)25-13/h6-10,12-13H,4-5,11H2,1-3H3,(H2,23,29)(H,25,28)/t13-/m0/s1
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Pfizer Inc.

US Patent


Assay Description
This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...


US Patent US10174000 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM319566
PNG
(1-(((4S,7R)-7-fluoro-6-oxo-5-azaspiro[2.4]heptan-4...)
Show SMILES CC(C)Oc1cc2c(OC[C@H]3NC(=O)[C@H](F)C33CC3)nccc2cc1C(N)=O
Show InChI InChI=1S/C20H22FN3O4/c1-10(2)28-14-8-12-11(7-13(14)17(22)25)3-6-23-19(12)27-9-15-20(4-5-20)16(21)18(26)24-15/h3,6-8,10,15-16H,4-5,9H2,1-2H3,(H2,22,25)(H,24,26)/t15-,16+/m1/s1
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Pfizer Inc.

US Patent


Assay Description
This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...


US Patent US10174000 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM319569
PNG
(1-(((4S,7R)-7-fluoro-6-oxo-5-azaspiro[2.4]heptan-4...)
Show SMILES COc1cc2c(OC[C@H]3NC(=O)[C@H](F)C33CC3)nccc2cc1C(N)=O
Show InChI InChI=1S/C18H18FN3O4/c1-25-12-7-10-9(6-11(12)15(20)23)2-5-21-17(10)26-8-13-18(3-4-18)14(19)16(24)22-13/h2,5-7,13-14H,3-4,8H2,1H3,(H2,20,23)(H,22,24)/t13-,14+/m1/s1
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Pfizer Inc.

US Patent


Assay Description
This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...


US Patent US10174000 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM319580
PNG
(5-{[(2S,3S,4S)-3-ethyl-4-fluoro-5-oxopyrrolidin-2-...)
Show SMILES CC[C@H]1[C@@H](COc2nccc3nc(C(N)=O)c(OC)cc23)NC(=O)[C@H]1F
Show InChI InChI=1S/C17H19FN4O4/c1-3-8-11(22-16(24)13(8)18)7-26-17-9-6-12(25-2)14(15(19)23)21-10(9)4-5-20-17/h4-6,8,11,13H,3,7H2,1-2H3,(H2,19,23)(H,22,24)/t8-,11+,13-/m0/s1
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Pfizer Inc.

US Patent


Assay Description
This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...


US Patent US10174000 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM319569
PNG
(1-(((4S,7R)-7-fluoro-6-oxo-5-azaspiro[2.4]heptan-4...)
Show SMILES COc1cc2c(OC[C@H]3NC(=O)[C@H](F)C33CC3)nccc2cc1C(N)=O
Show InChI InChI=1S/C18H18FN3O4/c1-25-12-7-10-9(6-11(12)15(20)23)2-5-21-17(10)26-8-13-18(3-4-18)14(19)16(24)22-13/h2,5-7,13-14H,3-4,8H2,1H3,(H2,20,23)(H,22,24)/t13-,14+/m1/s1
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Pfizer Inc.

US Patent


Assay Description
This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...


US Patent US10174000 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM319573
PNG
(4-(((2S,3R)-3-ethyl-5-oxopyrrolidin-2-yl)methoxy)-...)
Show SMILES CC[C@@H]1CC(=O)N[C@@H]1COc1cncc2cc(C(N)=O)c(OC)cc12
Show InChI InChI=1S/C18H21N3O4/c1-3-10-5-17(22)21-14(10)9-25-16-8-20-7-11-4-13(18(19)23)15(24-2)6-12(11)16/h4,6-8,10,14H,3,5,9H2,1-2H3,(H2,19,23)(H,21,22)/t10-,14-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...


US Patent US10174000 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM319556
PNG
(4-(4,5-Dimethyl-1,3-oxazol-2-yl)-1-{[(2S)-5-oxopyr...)
Show SMILES CC(C)Oc1cc2c(OC[C@@H]3CCC(=O)N3)ncc(-c3nc(C)c(C)o3)c2cc1C(N)=O
Show InChI InChI=1S/C23H26N4O5/c1-11(2)31-19-8-16-15(7-17(19)21(24)29)18(23-26-12(3)13(4)32-23)9-25-22(16)30-10-14-5-6-20(28)27-14/h7-9,11,14H,5-6,10H2,1-4H3,(H2,24,29)(H,27,28)/t14-/m0/s1
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Pfizer Inc.

US Patent


Assay Description
This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...


US Patent US10174000 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM319558
PNG
(4-(5-Methyl-1,3-oxazol-2-yl)-1-{[(2S)-5-oxopyrroli...)
Show SMILES CC(C)Oc1cc2c(OC[C@@H]3CCC(=O)N3)ncc(-c3ncc(C)o3)c2cc1C(N)=O
Show InChI InChI=1S/C22H24N4O5/c1-11(2)30-18-7-15-14(6-16(18)20(23)28)17(22-24-8-12(3)31-22)9-25-21(15)29-10-13-4-5-19(27)26-13/h6-9,11,13H,4-5,10H2,1-3H3,(H2,23,28)(H,26,27)/t13-/m0/s1
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Pfizer Inc.

US Patent


Assay Description
This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...


US Patent US10174000 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM319571
PNG
(1-(((4R,7R)-7-fluoro-6-oxo-5-azaspiro[2.4]heptan-4...)
Show SMILES COc1cc2c(OC[C@@H]3NC(=O)[C@H](F)C33CC3)nccc2cc1C(N)=O
Show InChI InChI=1S/C18H18FN3O4/c1-25-12-7-10-9(6-11(12)15(20)23)2-5-21-17(10)26-8-13-18(3-4-18)14(19)16(24)22-13/h2,5-7,13-14H,3-4,8H2,1H3,(H2,20,23)(H,22,24)/t13-,14-/m0/s1
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Pfizer Inc.

US Patent


Assay Description
This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...


US Patent US10174000 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM319553
PNG
(4-(1-Methyl-1H-pyrazol-3-yl)-1-{[(2S)-5-oxopyrroli...)
Show SMILES CC(C)Oc1cc2c(OC[C@@H]3CCC(=O)N3)ncc(-c3ccn(C)n3)c2cc1C(N)=O
Show InChI InChI=1S/C22H25N5O4/c1-12(2)31-19-9-15-14(8-16(19)21(23)29)17(18-6-7-27(3)26-18)10-24-22(15)30-11-13-4-5-20(28)25-13/h6-10,12-13H,4-5,11H2,1-3H3,(H2,23,29)(H,25,28)/t13-/m0/s1
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Pfizer Inc.

US Patent


Assay Description
This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...


US Patent US10174000 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM319578
PNG
(7-methoxy-1-{[(1S,5S)-3-oxo-2-azabicyclo[3.1.0]hex...)
Show SMILES COc1cc2c(OC[C@]34C[C@H]3CC(=O)N4)nccc2cc1C(N)=O
Show InChI InChI=1S/C17H17N3O4/c1-23-13-6-11-9(4-12(13)15(18)22)2-3-19-16(11)24-8-17-7-10(17)5-14(21)20-17/h2-4,6,10H,5,7-8H2,1H3,(H2,18,22)(H,20,21)/t10-,17-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...


US Patent US10174000 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM319551
PNG
(4-(1,3-Oxazol-2-yl)-1-{[(2S)-5-oxopyrrolidin-2-yl]...)
Show SMILES CC(C)Oc1cc2c(OC[C@@H]3CCC(=O)N3)ncc(-c3ncco3)c2cc1C(N)=O
Show InChI InChI=1S/C21H22N4O5/c1-11(2)30-17-8-14-13(7-15(17)19(22)27)16(21-23-5-6-28-21)9-24-20(14)29-10-12-3-4-18(26)25-12/h5-9,11-12H,3-4,10H2,1-2H3,(H2,22,27)(H,25,26)/t12-/m0/s1
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Pfizer Inc.

US Patent


Assay Description
This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...


US Patent US10174000 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM319557
PNG
(4-[4-(Hydroxymethyl)-1H-imidazol-2-yl]-1-{[(2S)-5-...)
Show SMILES CC(C)Oc1cc2c(OC[C@@H]3CCC(=O)N3)ncc(-c3nc(CO)c[nH]3)c2cc1C(N)=O
Show InChI InChI=1S/C22H25N5O5/c1-11(2)32-18-6-15-14(5-16(18)20(23)30)17(21-24-7-13(9-28)27-21)8-25-22(15)31-10-12-3-4-19(29)26-12/h5-8,11-12,28H,3-4,9-10H2,1-2H3,(H2,23,30)(H,24,27)(H,26,29)/t12-/m0/s1
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Pfizer Inc.

US Patent


Assay Description
This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...


US Patent US10174000 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM319555
PNG
(4-(4-Methyl-1,3-oxazol-2-yl)-1-{[(2S)-5-oxopyrroli...)
Show SMILES CC(C)Oc1cc2c(OC[C@@H]3CCC(=O)N3)ncc(-c3nc(C)co3)c2cc1C(N)=O
Show InChI InChI=1S/C22H24N4O5/c1-11(2)31-18-7-15-14(6-16(18)20(23)28)17(22-25-12(3)9-29-22)8-24-21(15)30-10-13-4-5-19(27)26-13/h6-9,11,13H,4-5,10H2,1-3H3,(H2,23,28)(H,26,27)/t13-/m0/s1
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Pfizer Inc.

US Patent


Assay Description
This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...


US Patent US10174000 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM319552
PNG
(4-(4-Methyl-1H-imidazol-2-yl)-1-{[(2S)-5-oxopyrrol...)
Show SMILES CC(C)Oc1cc2c(OC[C@@H]3CCC(=O)N3)ncc(-c3nc(C)c[nH]3)c2cc1C(N)=O
Show InChI InChI=1S/C22H25N5O4/c1-11(2)31-18-7-15-14(6-16(18)20(23)29)17(21-24-8-12(3)26-21)9-25-22(15)30-10-13-4-5-19(28)27-13/h6-9,11,13H,4-5,10H2,1-3H3,(H2,23,29)(H,24,26)(H,27,28)/t13-/m0/s1
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Pfizer Inc.

US Patent


Assay Description
This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...


US Patent US10174000 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM319577
PNG
(7-methoxy-1-[(3-oxo-2-azabicyclo[3.1.0]hex-1-yl)me...)
Show SMILES COc1cc2c(OCC34CC3CC(=O)N4)nccc2cc1C(N)=O
Show InChI InChI=1S/C17H17N3O4/c1-23-13-6-11-9(4-12(13)15(18)22)2-3-19-16(11)24-8-17-7-10(17)5-14(21)20-17/h2-4,6,10H,5,7-8H2,1H3,(H2,18,22)(H,20,21)
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Pfizer Inc.

US Patent


Assay Description
This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...


US Patent US10174000 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM319565
PNG
(1-(((4R,7S)-7-fluoro-6-oxo-5-azaspiro[2.4]heptan-4...)
Show SMILES CC(C)Oc1cc2c(OC[C@@H]3NC(=O)[C@@H](F)C33CC3)nccc2cc1C(N)=O
Show InChI InChI=1S/C20H22FN3O4/c1-10(2)28-14-8-12-11(7-13(14)17(22)25)3-6-23-19(12)27-9-15-20(4-5-20)16(21)18(26)24-15/h3,6-8,10,15-16H,4-5,9H2,1-2H3,(H2,22,25)(H,24,26)/t15-,16+/m0/s1
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n/an/a 390n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...


US Patent US10174000 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM319567
PNG
(Racemic 1-(((syn)-7-fluoro-6-oxo-5-azaspiro[2.4]he...)
Show SMILES CC(C)Oc1cc2c(OC[C@@H]3NC(=O)[C@H](F)C33CC3)nccc2cc1C(N)=O
Show InChI InChI=1S/C20H22FN3O4/c1-10(2)28-14-8-12-11(7-13(14)17(22)25)3-6-23-19(12)27-9-15-20(4-5-20)16(21)18(26)24-15/h3,6-8,10,15-16H,4-5,9H2,1-2H3,(H2,22,25)(H,24,26)/t15-,16-/m0/s1
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n/an/a 870n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...


US Patent US10174000 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM319579
PNG
(7-methoxy-1-{[(1R,5R)-3-oxo-2-azabicyclo[3.1.0]hex...)
Show SMILES COc1cc2c(OC[C@@]34C[C@@H]3CC(=O)N4)nccc2cc1C(N)=O
Show InChI InChI=1S/C17H17N3O4/c1-23-13-6-11-9(4-12(13)15(18)22)2-3-19-16(11)24-8-17-7-10(17)5-14(21)20-17/h2-4,6,10H,5,7-8H2,1H3,(H2,18,22)(H,20,21)/t10-,17-/m0/s1
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Pfizer Inc.

US Patent


Assay Description
This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...


US Patent US10174000 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM319560
PNG
(1-{[(2S,3R)-3-Ethyl-5-oxopyrrolidin-2-yl]methoxy}-...)
Show SMILES CC[C@@H]1CC(=O)N[C@@H]1COc1ncc(NS(=O)(=O)c2cccnc2)c2cc(C(N)=O)c(OC(C)C)cc12
Show InChI InChI=1S/C25H29N5O6S/c1-4-15-8-23(31)29-21(15)13-35-25-18-10-22(36-14(2)3)19(24(26)32)9-17(18)20(12-28-25)30-37(33,34)16-6-5-7-27-11-16/h5-7,9-12,14-15,21,30H,4,8,13H2,1-3H3,(H2,26,32)(H,29,31)/t15-,21-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...


US Patent US10174000 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM319571
PNG
(1-(((4R,7R)-7-fluoro-6-oxo-5-azaspiro[2.4]heptan-4...)
Show SMILES COc1cc2c(OC[C@@H]3NC(=O)[C@H](F)C33CC3)nccc2cc1C(N)=O
Show InChI InChI=1S/C18H18FN3O4/c1-25-12-7-10-9(6-11(12)15(20)23)2-5-21-17(10)26-8-13-18(3-4-18)14(19)16(24)22-13/h2,5-7,13-14H,3-4,8H2,1H3,(H2,20,23)(H,22,24)/t13-,14-/m0/s1
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Pfizer Inc.

US Patent


Assay Description
This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...


US Patent US10174000 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM319570
PNG
(1-(((4R,7S)-7-fluoro-6-oxo-5-azaspiro[2.4]heptan-4...)
Show SMILES COc1cc2c(OC[C@@H]3NC(=O)[C@@H](F)C33CC3)nccc2cc1C(N)=O
Show InChI InChI=1S/C18H18FN3O4/c1-25-12-7-10-9(6-11(12)15(20)23)2-5-21-17(10)26-8-13-18(3-4-18)14(19)16(24)22-13/h2,5-7,13-14H,3-4,8H2,1H3,(H2,20,23)(H,22,24)/t13-,14+/m0/s1
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Pfizer Inc.

US Patent


Assay Description
This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...


US Patent US10174000 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM319576
PNG
((3S,6R)-5-oxo-2,3,4,5,6,7,9,10-octahydro-12,14-(et...)
Show SMILES NC(=O)c1cc2ccnc3OC[C@@H]4C[C@H](COCCOc1cc23)C(=O)N4
Show InChI InChI=1S/C18H19N3O5/c19-16(22)14-6-10-1-2-20-18-13(10)7-15(14)25-4-3-24-8-11-5-12(9-26-18)21-17(11)23/h1-2,6-7,11-12H,3-5,8-9H2,(H2,19,22)(H,21,23)/t11-,12+/m1/s1
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Pfizer Inc.

US Patent


Assay Description
This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...


US Patent US10174000 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM319581
PNG
(1-(((2S,3S,4S)-4-fluoro-3-methyl-5-oxopyrrolidin-2...)
Show SMILES CNC(=O)c1nc2ccnc(OC[C@H]3NC(=O)[C@@H](F)[C@H]3C)c2cc1OC
Show InChI InChI=1S/C17H19FN4O4/c1-8-11(22-15(23)13(8)18)7-26-17-9-6-12(25-3)14(16(24)19-2)21-10(9)4-5-20-17/h4-6,8,11,13H,7H2,1-3H3,(H,19,24)(H,22,23)/t8-,11+,13-/m0/s1
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Pfizer Inc.

US Patent


Assay Description
This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...


US Patent US10174000 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM319557
PNG
(4-[4-(Hydroxymethyl)-1H-imidazol-2-yl]-1-{[(2S)-5-...)
Show SMILES CC(C)Oc1cc2c(OC[C@@H]3CCC(=O)N3)ncc(-c3nc(CO)c[nH]3)c2cc1C(N)=O
Show InChI InChI=1S/C22H25N5O5/c1-11(2)32-18-6-15-14(5-16(18)20(23)30)17(21-24-7-13(9-28)27-21)8-25-22(15)31-10-12-3-4-19(29)26-12/h5-8,11-12,28H,3-4,9-10H2,1-2H3,(H2,23,30)(H,24,27)(H,26,29)/t12-/m0/s1
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Pfizer Inc.

US Patent


Assay Description
This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...


US Patent US10174000 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM319552
PNG
(4-(4-Methyl-1H-imidazol-2-yl)-1-{[(2S)-5-oxopyrrol...)
Show SMILES CC(C)Oc1cc2c(OC[C@@H]3CCC(=O)N3)ncc(-c3nc(C)c[nH]3)c2cc1C(N)=O
Show InChI InChI=1S/C22H25N5O4/c1-11(2)31-18-7-15-14(6-16(18)20(23)29)17(21-24-8-12(3)26-21)9-25-22(15)30-10-13-4-5-19(28)27-13/h6-9,11,13H,4-5,10H2,1-3H3,(H2,23,29)(H,24,26)(H,27,28)/t13-/m0/s1
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Pfizer Inc.

US Patent


Assay Description
This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...


US Patent US10174000 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM319577
PNG
(7-methoxy-1-[(3-oxo-2-azabicyclo[3.1.0]hex-1-yl)me...)
Show SMILES COc1cc2c(OCC34CC3CC(=O)N4)nccc2cc1C(N)=O
Show InChI InChI=1S/C17H17N3O4/c1-23-13-6-11-9(4-12(13)15(18)22)2-3-19-16(11)24-8-17-7-10(17)5-14(21)20-17/h2-4,6,10H,5,7-8H2,1H3,(H2,18,22)(H,20,21)
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Pfizer Inc.

US Patent


Assay Description
This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...


US Patent US10174000 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM319578
PNG
(7-methoxy-1-{[(1S,5S)-3-oxo-2-azabicyclo[3.1.0]hex...)
Show SMILES COc1cc2c(OC[C@]34C[C@H]3CC(=O)N4)nccc2cc1C(N)=O
Show InChI InChI=1S/C17H17N3O4/c1-23-13-6-11-9(4-12(13)15(18)22)2-3-19-16(11)24-8-17-7-10(17)5-14(21)20-17/h2-4,6,10H,5,7-8H2,1H3,(H2,18,22)(H,20,21)/t10-,17-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...


US Patent US10174000 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM319565
PNG
(1-(((4R,7S)-7-fluoro-6-oxo-5-azaspiro[2.4]heptan-4...)
Show SMILES CC(C)Oc1cc2c(OC[C@@H]3NC(=O)[C@@H](F)C33CC3)nccc2cc1C(N)=O
Show InChI InChI=1S/C20H22FN3O4/c1-10(2)28-14-8-12-11(7-13(14)17(22)25)3-6-23-19(12)27-9-15-20(4-5-20)16(21)18(26)24-15/h3,6-8,10,15-16H,4-5,9H2,1-2H3,(H2,22,25)(H,24,26)/t15-,16+/m0/s1
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Pfizer Inc.

US Patent


Assay Description
This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...


US Patent US10174000 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM319559
PNG
(1-{[(2S,3R)-3-ethyl-5-oxopyrrolidin-2-yl]methoxy}-...)
Show SMILES CC[C@@H]1CC(=O)N[C@@H]1COc1ncc(NS(=O)(=O)c2ccccc2)c2cc(C(N)=O)c(OC(C)C)cc12
Show InChI InChI=1S/C26H30N4O6S/c1-4-16-10-24(31)29-22(16)14-35-26-19-12-23(36-15(2)3)20(25(27)32)11-18(19)21(13-28-26)30-37(33,34)17-8-6-5-7-9-17/h5-9,11-13,15-16,22,30H,4,10,14H2,1-3H3,(H2,27,32)(H,29,31)/t16-,22-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...


US Patent US10174000 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM319561
PNG
(1-{[(2S,3R)-3-Ethyl-5-oxopyrrolidin-2-yl]methoxy}-...)
Show SMILES CC[C@@H]1CC(=O)N[C@@H]1COc1ncc(NS(=O)(=O)c2c[nH]cn2)c2cc(C(N)=O)c(OC(C)C)cc12
Show InChI InChI=1S/C23H28N6O6S/c1-4-13-5-20(30)28-18(13)10-34-23-15-7-19(35-12(2)3)16(22(24)31)6-14(15)17(8-26-23)29-36(32,33)21-9-25-11-27-21/h6-9,11-13,18,29H,4-5,10H2,1-3H3,(H2,24,31)(H,25,27)(H,28,30)/t13-,18-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...


US Patent US10174000 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM319562
PNG
(1-{[(2S,3R)-3-Ethyl-5-oxopyrrolidin-2-yl]methoxy}-...)
Show SMILES CC[C@@H]1CC(=O)N[C@@H]1COc1ncc(NS(=O)(=O)c2cn(C)cn2)c2cc(C(N)=O)c(OC(C)C)cc12
Show InChI InChI=1S/C24H30N6O6S/c1-5-14-6-21(31)28-19(14)11-35-24-16-8-20(36-13(2)3)17(23(25)32)7-15(16)18(9-26-24)29-37(33,34)22-10-30(4)12-27-22/h7-10,12-14,19,29H,5-6,11H2,1-4H3,(H2,25,32)(H,28,31)/t14-,19-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...


US Patent US10174000 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM319563
PNG
(4-{[(1,2-Dimethyl-1H-imidazol-4-yl)sulfonyl]amino}...)
Show SMILES CC[C@@H]1CC(=O)N[C@@H]1COc1ncc(NS(=O)(=O)c2cn(C)c(C)n2)c2cc(C(N)=O)c(OC(C)C)cc12
Show InChI InChI=1S/C25H32N6O6S/c1-6-15-7-22(32)29-20(15)12-36-25-17-9-21(37-13(2)3)18(24(26)33)8-16(17)19(10-27-25)30-38(34,35)23-11-31(5)14(4)28-23/h8-11,13,15,20,30H,6-7,12H2,1-5H3,(H2,26,33)(H,29,32)/t15-,20-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...


US Patent US10174000 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM319567
PNG
(Racemic 1-(((syn)-7-fluoro-6-oxo-5-azaspiro[2.4]he...)
Show SMILES CC(C)Oc1cc2c(OC[C@@H]3NC(=O)[C@H](F)C33CC3)nccc2cc1C(N)=O
Show InChI InChI=1S/C20H22FN3O4/c1-10(2)28-14-8-12-11(7-13(14)17(22)25)3-6-23-19(12)27-9-15-20(4-5-20)16(21)18(26)24-15/h3,6-8,10,15-16H,4-5,9H2,1-2H3,(H2,22,25)(H,24,26)/t15-,16-/m0/s1
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Pfizer Inc.

US Patent


Assay Description
This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...


US Patent US10174000 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM319570
PNG
(1-(((4R,7S)-7-fluoro-6-oxo-5-azaspiro[2.4]heptan-4...)
Show SMILES COc1cc2c(OC[C@@H]3NC(=O)[C@@H](F)C33CC3)nccc2cc1C(N)=O
Show InChI InChI=1S/C18H18FN3O4/c1-25-12-7-10-9(6-11(12)15(20)23)2-5-21-17(10)26-8-13-18(3-4-18)14(19)16(24)22-13/h2,5-7,13-14H,3-4,8H2,1H3,(H2,20,23)(H,22,24)/t13-,14+/m0/s1
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Pfizer Inc.

US Patent


Assay Description
This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...


US Patent US10174000 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM319563
PNG
(4-{[(1,2-Dimethyl-1H-imidazol-4-yl)sulfonyl]amino}...)
Show SMILES CC[C@@H]1CC(=O)N[C@@H]1COc1ncc(NS(=O)(=O)c2cn(C)c(C)n2)c2cc(C(N)=O)c(OC(C)C)cc12
Show InChI InChI=1S/C25H32N6O6S/c1-6-15-7-22(32)29-20(15)12-36-25-17-9-21(37-13(2)3)18(24(26)33)8-16(17)19(10-27-25)30-38(34,35)23-11-31(5)14(4)28-23/h8-11,13,15,20,30H,6-7,12H2,1-5H3,(H2,26,33)(H,29,32)/t15-,20-/m1/s1
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n/an/a 2.90E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...


US Patent US10174000 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM319579
PNG
(7-methoxy-1-{[(1R,5R)-3-oxo-2-azabicyclo[3.1.0]hex...)
Show SMILES COc1cc2c(OC[C@@]34C[C@@H]3CC(=O)N4)nccc2cc1C(N)=O
Show InChI InChI=1S/C17H17N3O4/c1-23-13-6-11-9(4-12(13)15(18)22)2-3-19-16(11)24-8-17-7-10(17)5-14(21)20-17/h2-4,6,10H,5,7-8H2,1H3,(H2,18,22)(H,20,21)/t10-,17-/m0/s1
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Pfizer Inc.

US Patent


Assay Description
This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...


US Patent US10174000 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM319559
PNG
(1-{[(2S,3R)-3-ethyl-5-oxopyrrolidin-2-yl]methoxy}-...)
Show SMILES CC[C@@H]1CC(=O)N[C@@H]1COc1ncc(NS(=O)(=O)c2ccccc2)c2cc(C(N)=O)c(OC(C)C)cc12
Show InChI InChI=1S/C26H30N4O6S/c1-4-16-10-24(31)29-22(16)14-35-26-19-12-23(36-15(2)3)20(25(27)32)11-18(19)21(13-28-26)30-37(33,34)17-8-6-5-7-9-17/h5-9,11-13,15-16,22,30H,4,10,14H2,1-3H3,(H2,27,32)(H,29,31)/t16-,22-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...


US Patent US10174000 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM319562
PNG
(1-{[(2S,3R)-3-Ethyl-5-oxopyrrolidin-2-yl]methoxy}-...)
Show SMILES CC[C@@H]1CC(=O)N[C@@H]1COc1ncc(NS(=O)(=O)c2cn(C)cn2)c2cc(C(N)=O)c(OC(C)C)cc12
Show InChI InChI=1S/C24H30N6O6S/c1-5-14-6-21(31)28-19(14)11-35-24-16-8-20(36-13(2)3)17(23(25)32)7-15(16)18(9-26-24)29-37(33,34)22-10-30(4)12-27-22/h7-10,12-14,19,29H,5-6,11H2,1-4H3,(H2,25,32)(H,28,31)/t14-,19-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...


US Patent US10174000 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM319561
PNG
(1-{[(2S,3R)-3-Ethyl-5-oxopyrrolidin-2-yl]methoxy}-...)
Show SMILES CC[C@@H]1CC(=O)N[C@@H]1COc1ncc(NS(=O)(=O)c2c[nH]cn2)c2cc(C(N)=O)c(OC(C)C)cc12
Show InChI InChI=1S/C23H28N6O6S/c1-4-13-5-20(30)28-18(13)10-34-23-15-7-19(35-12(2)3)16(22(24)31)6-14(15)17(8-26-23)29-36(32,33)21-9-25-11-27-21/h6-9,11-13,18,29H,4-5,10H2,1-3H3,(H2,24,31)(H,25,27)(H,28,30)/t13-,18-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...


US Patent US10174000 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM319560
PNG
(1-{[(2S,3R)-3-Ethyl-5-oxopyrrolidin-2-yl]methoxy}-...)
Show SMILES CC[C@@H]1CC(=O)N[C@@H]1COc1ncc(NS(=O)(=O)c2cccnc2)c2cc(C(N)=O)c(OC(C)C)cc12
Show InChI InChI=1S/C25H29N5O6S/c1-4-15-8-23(31)29-21(15)13-35-25-18-10-22(36-14(2)3)19(24(26)32)9-17(18)20(12-28-25)30-37(33,34)16-6-5-7-27-11-16/h5-7,9-12,14-15,21,30H,4,8,13H2,1-3H3,(H2,26,32)(H,29,31)/t15-,21-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...


US Patent US10174000 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%