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Patent code US10174003

Compile Data Set for Download or QSAR

Found 329 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (human))
BDBM319678
PNG
(2-[5-(4-fluorophenyl)-1-methyl-1H-imidazol-4-yl]-4...)
Show SMILES Cn1cnc(c1-c1ccc(F)cc1)-c1cc(ccn1)-c1nn[nH]c1C(F)(F)F
Show InChI InChI=1S/C18H12F4N6/c1-28-9-24-15(16(28)10-2-4-12(19)5-3-10)13-8-11(6-7-23-13)14-17(18(20,21)22)26-27-25-14/h2-9H,1H3,(H,25,26,27)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10174003 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM319684
PNG
(2-{1-[(7-methyl-1,2,3,4-tetrahydronaphthalen-1- yl...)
Show SMILES Cc1ccc2CCCC(Cn3cnc(c3)-c3cc(ccn3)-c3nn[nH]c3C(F)(F)F)c2c1
Show InChI InChI=1S/C23H21F3N6/c1-14-5-6-15-3-2-4-17(18(15)9-14)11-32-12-20(28-13-32)19-10-16(7-8-27-19)21-22(23(24,25)26)30-31-29-21/h5-10,12-13,17H,2-4,11H2,1H3,(H,29,30,31)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US10174003 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2A (KDM2A)


(Homo sapiens (human))
BDBM276042
PNG
(2-[5-[2-(cyclopropylmethoxy)-4-fluorophenyl]-1-met...)
Show SMILES Cn1cnc(c1-c1ccc(F)cc1OCC1CC1)-c1cc(ccn1)-c1c[nH]nn1
Show InChI InChI=1S/C21H19FN6O/c1-28-12-24-20(17-8-14(6-7-23-17)18-10-25-27-26-18)21(28)16-5-4-15(22)9-19(16)29-11-13-2-3-13/h4-10,12-13H,2-3,11H2,1H3,(H,25,26,27)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL11 was determined in 384-well plate format under the following reaction conditions: 0.15...


US Patent US10174003 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2A (KDM2A)


(Homo sapiens (human))
BDBM276044
PNG
(2-[1-[2-(2-chlorophenyl)ethyl]imidazol-4-yl]-4-(1H...)
Show SMILES Clc1ccccc1CCn1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1
Show InChI InChI=1S/C18H15ClN6/c19-15-4-2-1-3-13(15)6-8-25-11-18(21-12-25)16-9-14(5-7-20-16)17-10-22-24-23-17/h1-5,7,9-12H,6,8H2,(H,22,23,24)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL11 was determined in 384-well plate format under the following reaction conditions: 0.15...


US Patent US10174003 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (human))
BDBM319595
PNG
(4-[2-[1-[(2,3-dichlorophenyl)methyl]imidazol- 4-yl...)
Show SMILES Clc1cccc(Cn2cnc(c2)-c2cc(ccn2)-c2nn[nH]c2[N+]#[C-])c1Cl
Show InChI InChI=1S/C18H11Cl2N7/c1-21-18-17(24-26-25-18)11-5-6-22-14(7-11)15-9-27(10-23-15)8-12-3-2-4-13(19)16(12)20/h2-7,9-10H,8H2,(H,24,25,26)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10174003 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (human))
BDBM276055
PNG
(2-[1-[2-(2-phenylmethoxyphenyl)ethyl]imidazol-4-yl...)
Show SMILES C(Cn1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1)c1ccccc1OCc1ccccc1
Show InChI InChI=1S/C25H22N6O/c1-2-6-19(7-3-1)17-32-25-9-5-4-8-20(25)11-13-31-16-24(27-18-31)22-14-21(10-12-26-22)23-15-28-30-29-23/h1-10,12,14-16,18H,11,13,17H2,(H,28,29,30)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10174003 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (human))
BDBM276070
PNG
(2-[1-[2-(2-chlorophenyl)-2-methylpropyl]imidazol-4...)
Show SMILES CC(C)(Cn1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1)c1ccccc1Cl
Show InChI InChI=1S/C20H19ClN6/c1-20(2,15-5-3-4-6-16(15)21)12-27-11-19(23-13-27)17-9-14(7-8-22-17)18-10-24-26-25-18/h3-11,13H,12H2,1-2H3,(H,24,25,26)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10174003 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (human))
BDBM276082
PNG
(1-benzyl-4-{1H-[1,2,3]triazolo[4,5-c]pyridin-6-yl}...)
Show SMILES C(c1ccccc1)n1cnc(c1)-c1cc2[nH]nnc2cn1
Show InChI InChI=1S/C15H12N6/c1-2-4-11(5-3-1)8-21-9-15(17-10-21)12-6-13-14(7-16-12)19-20-18-13/h1-7,9-10H,8H2,(H,18,19,20)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10174003 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (human))
BDBM276085
PNG
(1-[(4-chlorophenyl)methyl]-4-{1H-[1,2,3]triazolo[4...)
Show SMILES Clc1ccc(Cn2cnc(c2)-c2cc3[nH]nnc3cn2)cc1
Show InChI InChI=1S/C15H11ClN6/c16-11-3-1-10(2-4-11)7-22-8-15(18-9-22)12-5-13-14(6-17-12)20-21-19-13/h1-6,8-9H,7H2,(H,19,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10174003 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (human))
BDBM276088
PNG
(1-(2-chlorophenyl)-4-{1H-[1,2,3]triazolo[4,5-c]pyr...)
Show SMILES Clc1ccccc1-n1cnc(c1)-c1cc2[nH]nnc2cn1
Show InChI InChI=1S/C14H9ClN6/c15-9-3-1-2-4-14(9)21-7-13(17-8-21)10-5-11-12(6-16-10)19-20-18-11/h1-8H,(H,18,19,20)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10174003 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (human))
BDBM319643
PNG
(2-{1-[(4-fluorophenyl)methyl]-1H-imidazol-4-yl}-4-...)
Show SMILES Fc1ccccc1Cn1cnc(c1)-c1cc(ccn1)-c1nn[nH]c1C(F)(F)F
Show InChI InChI=1S/C18H12F4N6/c19-13-4-2-1-3-12(13)8-28-9-15(24-10-28)14-7-11(5-6-23-14)16-17(18(20,21)22)26-27-25-16/h1-7,9-10H,8H2,(H,25,26,27)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10174003 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (human))
BDBM319647
PNG
(2-{1-[(2-methylphenyl)methyl]-1H-imidazol-4-yl}-4-...)
Show SMILES Cc1ccccc1Cn1cnc(c1)-c1cc(ccn1)-c1nn[nH]c1C(F)(F)F
Show InChI InChI=1S/C19H15F3N6/c1-12-4-2-3-5-14(12)9-28-10-16(24-11-28)15-8-13(6-7-23-15)17-18(19(20,21)22)26-27-25-17/h2-8,10-11H,9H2,1H3,(H,25,26,27)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10174003 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM319660
PNG
(2-{1-[2-(2,3-difluorophenyl)ethyl]-1H-imidazol- 4-...)
Show SMILES Fc1cccc(CCn2cnc(c2)-c2cc(ccn2)-c2nn[nH]c2C(F)(F)F)c1F
Show InChI InChI=1S/C19H13F5N6/c20-13-3-1-2-11(16(13)21)5-7-30-9-15(26-10-30)14-8-12(4-6-25-14)17-18(19(22,23)24)28-29-27-17/h1-4,6,8-10H,5,7H2,(H,27,28,29)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US10174003 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM319662
PNG
(4-[5-(trifluoromethyl)-1H-1,2,3-triazol-4-yl]-2-{1...)
Show SMILES Fc1cc(F)c(CCn2cnc(c2)-c2cc(ccn2)-c2nn[nH]c2C(F)(F)F)cc1F
Show InChI InChI=1S/C19H12F6N6/c20-12-7-14(22)13(21)5-10(12)2-4-31-8-16(27-9-31)15-6-11(1-3-26-15)17-18(19(23,24)25)29-30-28-17/h1,3,5-9H,2,4H2,(H,28,29,30)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US10174003 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM319665
PNG
(2-{1-[2-(2-fluorophenyl)ethyl]-1H-imidazol-4-yl}-4...)
Show SMILES Fc1ccccc1CCn1cnc(c1)-c1cc(ccn1)-c1nn[nH]c1C(F)(F)F
Show InChI InChI=1S/C19H14F4N6/c20-14-4-2-1-3-12(14)6-8-29-10-16(25-11-29)15-9-13(5-7-24-15)17-18(19(21,22)23)27-28-26-17/h1-5,7,9-11H,6,8H2,(H,26,27,28)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US10174003 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (human))
BDBM319667
PNG
(2-{1-[2-(2,4-difluorophenyl)ethyl]-1H-imidazol-4- ...)
Show SMILES Fc1ccc(CCn2cnc(c2)-c2cc(ccn2)-c2nn[nH]c2C(F)(F)F)c(F)c1
Show InChI InChI=1S/C19H13F5N6/c20-13-2-1-11(14(21)8-13)4-6-30-9-16(26-10-30)15-7-12(3-5-25-15)17-18(19(22,23)24)28-29-27-17/h1-3,5,7-10H,4,6H2,(H,27,28,29)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10174003 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM319667
PNG
(2-{1-[2-(2,4-difluorophenyl)ethyl]-1H-imidazol-4- ...)
Show SMILES Fc1ccc(CCn2cnc(c2)-c2cc(ccn2)-c2nn[nH]c2C(F)(F)F)c(F)c1
Show InChI InChI=1S/C19H13F5N6/c20-13-2-1-11(14(21)8-13)4-6-30-9-16(26-10-30)15-7-12(3-5-25-15)17-18(19(22,23)24)28-29-27-17/h1-3,5,7-10H,4,6H2,(H,27,28,29)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US10174003 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (human))
BDBM319672
PNG
(2-{1-[2-(4-methylphenyl)ethyl]-1H-imidazol-4-yl}- ...)
Show SMILES Cc1ccc(CCn2cnc(c2)-c2cc(ccn2)-c2nn[nH]c2C(F)(F)F)cc1
Show InChI InChI=1S/C20H17F3N6/c1-13-2-4-14(5-3-13)7-9-29-11-17(25-12-29)16-10-15(6-8-24-16)18-19(20(21,22)23)27-28-26-18/h2-6,8,10-12H,7,9H2,1H3,(H,26,27,28)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10174003 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (human))
BDBM319679
PNG
(2-{1-[(3,4-dihydro-2H-1-benzopyran-4-yl)methyl]- 1...)
Show SMILES FC(F)(F)c1[nH]nnc1-c1ccnc(c1)-c1cn(CC2CCOc3ccccc23)cn1
Show InChI InChI=1S/C21H17F3N6O/c22-21(23,24)20-19(27-29-28-20)13-5-7-25-16(9-13)17-11-30(12-26-17)10-14-6-8-31-18-4-2-1-3-15(14)18/h1-5,7,9,11-12,14H,6,8,10H2,(H,27,28,29)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10174003 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (human))
BDBM276044
PNG
(2-[1-[2-(2-chlorophenyl)ethyl]imidazol-4-yl]-4-(1H...)
Show SMILES Clc1ccccc1CCn1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1
Show InChI InChI=1S/C18H15ClN6/c19-15-4-2-1-3-13(15)6-8-25-11-18(21-12-25)16-9-14(5-7-20-16)17-10-22-24-23-17/h1-5,7,9-12H,6,8H2,(H,22,23,24)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10174003 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (human))
BDBM276045
PNG
(2-[1-[2-(2-methoxyphenyl)ethyl]imidazol-4-yl]-4-(1...)
Show SMILES COc1ccccc1CCn1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1
Show InChI InChI=1S/C19H18N6O/c1-26-19-5-3-2-4-14(19)7-9-25-12-18(21-13-25)16-10-15(6-8-20-16)17-11-22-24-23-17/h2-6,8,10-13H,7,9H2,1H3,(H,22,23,24)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10174003 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (human))
BDBM276046
PNG
(2-[1-(1,2,3,4-tetrahydronaphthalen-1-ylmethyl)imid...)
Show SMILES C(C1CCCc2ccccc12)n1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1
Show InChI InChI=1S/C21H20N6/c1-2-7-18-15(4-1)5-3-6-17(18)12-27-13-21(23-14-27)19-10-16(8-9-22-19)20-11-24-26-25-20/h1-2,4,7-11,13-14,17H,3,5-6,12H2,(H,24,25,26)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10174003 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (human))
BDBM276047
PNG
(2-[1-[2-(2-ethoxyphenyl)ethyl]imidazol-4-yl]-4-(1H...)
Show SMILES CCOc1ccccc1CCn1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1
Show InChI InChI=1S/C20H20N6O/c1-2-27-20-6-4-3-5-15(20)8-10-26-13-19(22-14-26)17-11-16(7-9-21-17)18-12-23-25-24-18/h3-7,9,11-14H,2,8,10H2,1H3,(H,23,24,25)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10174003 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (human))
BDBM319596
PNG
(4-[2-[1-(1,2,3,4-tetrahydronaphthalen- 1-ylmethyl)...)
Show SMILES [C-]#[N+]c1[nH]nnc1-c1ccnc(c1)-c1cn(CC2CCCc3ccccc23)cn1
Show InChI InChI=1S/C22H19N7/c1-23-22-21(26-28-27-22)16-9-10-24-19(11-16)20-13-29(14-25-20)12-17-7-4-6-15-5-2-3-8-18(15)17/h2-3,5,8-11,13-14,17H,4,6-7,12H2,(H,26,27,28)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10174003 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (human))
BDBM319597
PNG
(4-[2-[1-(2-naphthalen-1-ylethyl)imidazol- 4-yl]pyr...)
Show SMILES [C-]#[N+]c1[nH]nnc1-c1ccnc(c1)-c1cn(CCc2cccc3ccccc23)cn1
Show InChI InChI=1S/C23H17N7/c1-24-23-22(27-29-28-23)18-9-11-25-20(13-18)21-14-30(15-26-21)12-10-17-7-4-6-16-5-2-3-8-19(16)17/h2-9,11,13-15H,10,12H2,(H,27,28,29)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10174003 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2A (KDM2A)


(Homo sapiens (human))
BDBM276061
PNG
(2-[1-(2-naphthalen-1-ylethyl)imidazol-4-yl]-4-(1H-...)
Show SMILES C(Cn1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1)c1cccc2ccccc12
Show InChI InChI=1S/C22H18N6/c1-2-7-19-16(4-1)5-3-6-17(19)9-11-28-14-22(24-15-28)20-12-18(8-10-23-20)21-13-25-27-26-21/h1-8,10,12-15H,9,11H2,(H,25,26,27)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL11 was determined in 384-well plate format under the following reaction conditions: 0.15...


US Patent US10174003 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM319639
PNG
(2-{1-[(1,2,3,4-tetrahydronaphthalen-1-yl)methyl]- ...)
Show SMILES FC(F)(F)c1[nH]nnc1-c1ccnc(c1)-c1cn(CC2CCCc3ccccc23)cn1
Show InChI InChI=1S/C22H19F3N6/c23-22(24,25)21-20(28-30-29-21)15-8-9-26-18(10-15)19-12-31(13-27-19)11-16-6-3-5-14-4-1-2-7-17(14)16/h1-2,4,7-10,12-13,16H,3,5-6,11H2,(H,28,29,30)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US10174003 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM319640
PNG
(2-{1-[2-(2-ethoxyphenyl)ethyl]-1H-imidazol-4-yl}-4...)
Show SMILES CCOc1ccccc1CCn1cnc(c1)-c1cc(ccn1)-c1nn[nH]c1C(F)(F)F
Show InChI InChI=1S/C21H19F3N6O/c1-2-31-18-6-4-3-5-14(18)8-10-30-12-17(26-13-30)16-11-15(7-9-25-16)19-20(21(22,23)24)28-29-27-19/h3-7,9,11-13H,2,8,10H2,1H3,(H,27,28,29)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US10174003 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (human))
BDBM319659
PNG
(2-{1-[2-(3-fluorophenyl)ethyl]-1H-imidazol-4-yl}-4...)
Show SMILES Fc1cccc(CCn2cnc(c2)-c2cc(ccn2)-c2nn[nH]c2C(F)(F)F)c1
Show InChI InChI=1S/C19H14F4N6/c20-14-3-1-2-12(8-14)5-7-29-10-16(25-11-29)15-9-13(4-6-24-15)17-18(19(21,22)23)27-28-26-17/h1-4,6,8-11H,5,7H2,(H,26,27,28)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10174003 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (human))
BDBM319665
PNG
(2-{1-[2-(2-fluorophenyl)ethyl]-1H-imidazol-4-yl}-4...)
Show SMILES Fc1ccccc1CCn1cnc(c1)-c1cc(ccn1)-c1nn[nH]c1C(F)(F)F
Show InChI InChI=1S/C19H14F4N6/c20-14-4-2-1-3-12(14)6-8-29-10-16(25-11-29)15-9-13(5-7-24-15)17-18(19(21,22)23)27-28-26-17/h1-5,7,9-11H,6,8H2,(H,26,27,28)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10174003 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (human))
BDBM319669
PNG
(2-{1-[2-(2,5-difluorophenyl)ethyl]-1H-imidazol-4- ...)
Show SMILES Fc1ccc(F)c(CCn2cnc(c2)-c2cc(ccn2)-c2nn[nH]c2C(F)(F)F)c1
Show InChI InChI=1S/C19H13F5N6/c20-13-1-2-14(21)11(7-13)4-6-30-9-16(26-10-30)15-8-12(3-5-25-15)17-18(19(22,23)24)28-29-27-17/h1-3,5,7-10H,4,6H2,(H,27,28,29)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10174003 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM319687
PNG
(2-{1-[(7-methoxy-1,2,3,4-tetrahydronaphthalen-1- y...)
Show SMILES COc1ccc2CCCC(Cn3cnc(c3)-c3cc(ccn3)-c3nn[nH]c3C(F)(F)F)c2c1
Show InChI InChI=1S/C23H21F3N6O/c1-33-17-6-5-14-3-2-4-16(18(14)10-17)11-32-12-20(28-13-32)19-9-15(7-8-27-19)21-22(23(24,25)26)30-31-29-21/h5-10,12-13,16H,2-4,11H2,1H3,(H,29,30,31)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US10174003 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (human))
BDBM276040
PNG
(2-[1-[(2-chlorophenyl)methyl]imidazol-4-yl]-4-(1H-...)
Show SMILES Clc1ccccc1Cn1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1
Show InChI InChI=1S/C17H13ClN6/c18-14-4-2-1-3-13(14)9-24-10-17(20-11-24)15-7-12(5-6-19-15)16-8-21-23-22-16/h1-8,10-11H,9H2,(H,21,22,23)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10174003 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2A (KDM2A)


(Homo sapiens (human))
BDBM276043
PNG
(2-[1-(1-phenylethyl)imidazol-4-yl]-4-(1H-triazol-4...)
Show SMILES CC(c1ccccc1)n1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1
Show InChI InChI=1S/C18H16N6/c1-13(14-5-3-2-4-6-14)24-11-18(20-12-24)16-9-15(7-8-19-16)17-10-21-23-22-17/h2-13H,1H3,(H,21,22,23)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL11 was determined in 384-well plate format under the following reaction conditions: 0.15...


US Patent US10174003 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (human))
BDBM276063
PNG
(2-[5-(3-ethoxy-4-fluorophenyl)-1-methylimidazol-4-...)
Show SMILES CCOc1cc(ccc1F)-c1c(ncn1C)-c1cc(ccn1)-c1c[nH]nn1
Show InChI InChI=1S/C19H17FN6O/c1-3-27-17-9-13(4-5-14(17)20)19-18(22-11-26(19)2)15-8-12(6-7-21-15)16-10-23-25-24-16/h4-11H,3H2,1-2H3,(H,23,24,25)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10174003 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (human))
BDBM276086
PNG
(1-[(3,4-dichlorophenyl)methyl]-4-{1H-[1,2,3]triazo...)
Show SMILES Clc1ccc(Cn2cnc(c2)-c2cc3[nH]nnc3cn2)cc1Cl
Show InChI InChI=1S/C15H10Cl2N6/c16-10-2-1-9(3-11(10)17)6-23-7-15(19-8-23)12-4-13-14(5-18-12)21-22-20-13/h1-5,7-8H,6H2,(H,20,21,22)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10174003 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (human))
BDBM319638
PNG
(2-{1-[2-(2-chlorophenyl)ethyl]-1H-imidazol-4-yl}-4...)
Show SMILES FC(F)(F)c1[nH]nnc1-c1ccnc(c1)-c1cn(CCc2ccccc2Cl)cn1
Show InChI InChI=1S/C19H14ClF3N6/c20-14-4-2-1-3-12(14)6-8-29-10-16(25-11-29)15-9-13(5-7-24-15)17-18(19(21,22)23)27-28-26-17/h1-5,7,9-11H,6,8H2,(H,26,27,28)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10174003 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (human))
BDBM319650
PNG
(2-{1-[(2,6-difluorophenyl)methyl]-1H-imidazol-4- y...)
Show SMILES Fc1cccc(F)c1Cn1cnc(c1)-c1cc(ccn1)-c1nn[nH]c1C(F)(F)F
Show InChI InChI=1S/C18H11F5N6/c19-12-2-1-3-13(20)11(12)7-29-8-15(25-9-29)14-6-10(4-5-24-14)16-17(18(21,22)23)27-28-26-16/h1-6,8-9H,7H2,(H,26,27,28)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10174003 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM319658
PNG
(2-{1-[2-(4-fluorophenyl)ethyl]-1H-imidazol-4-yl}-4...)
Show SMILES FC(F)(F)c1[nH]nnc1-c1ccnc(c1)-c1cn(CCc2ccc(I)cc2)cn1
Show InChI InChI=1S/C19H14F3IN6/c20-19(21,22)18-17(26-28-27-18)13-5-7-24-15(9-13)16-10-29(11-25-16)8-6-12-1-3-14(23)4-2-12/h1-5,7,9-11H,6,8H2,(H,26,27,28)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US10174003 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (human))
BDBM319662
PNG
(4-[5-(trifluoromethyl)-1H-1,2,3-triazol-4-yl]-2-{1...)
Show SMILES Fc1cc(F)c(CCn2cnc(c2)-c2cc(ccn2)-c2nn[nH]c2C(F)(F)F)cc1F
Show InChI InChI=1S/C19H12F6N6/c20-12-7-14(22)13(21)5-10(12)2-4-31-8-16(27-9-31)15-6-11(1-3-26-15)17-18(19(23,24)25)29-30-28-17/h1,3,5-9H,2,4H2,(H,28,29,30)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10174003 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (human))
BDBM319663
PNG
(4-[5-(trifluoromethyl)-1H-1,2,3-triazol-4-yl]-2- {...)
Show SMILES Fc1cc(F)c(CCn2cnc(c2)-c2cc(ccn2)-c2nn[nH]c2C(F)(F)F)c(F)c1
Show InChI InChI=1S/C19H12F6N6/c20-11-6-13(21)12(14(22)7-11)2-4-31-8-16(27-9-31)15-5-10(1-3-26-15)17-18(19(23,24)25)29-30-28-17/h1,3,5-9H,2,4H2,(H,28,29,30)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10174003 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM319664
PNG
(2-{1-[(2,3-dihydro-1H-inden-1-yl)methyl]-1H- imida...)
Show SMILES FC(F)(F)c1[nH]nnc1-c1ccnc(c1)-c1cn(CC2CCc3ccccc23)cn1
Show InChI InChI=1S/C21H17F3N6/c22-21(23,24)20-19(27-29-28-20)14-7-8-25-17(9-14)18-11-30(12-26-18)10-15-6-5-13-3-1-2-4-16(13)15/h1-4,7-9,11-12,15H,5-6,10H2,(H,27,28,29)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US10174003 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM319671
PNG
(2-{1-[(3S)-1-benzoylpiperidin-3-yl]-1H-imidazol-4-...)
Show SMILES FC(F)(F)c1[nH]nnc1-c1ccnc(c1)-c1cn(cn1)[C@H]1CCCN(C1)C(=O)c1ccccc1
Show InChI InChI=1S/C23H20F3N7O/c24-23(25,26)21-20(29-31-30-21)16-8-9-27-18(11-16)19-13-33(14-28-19)17-7-4-10-32(12-17)22(34)15-5-2-1-3-6-15/h1-3,5-6,8-9,11,13-14,17H,4,7,10,12H2,(H,29,30,31)/t17-/m0/s1
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US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US10174003 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (human))
BDBM319674
PNG
(2-{1-[2-(4-methoxyphenyl)ethyl]-1H-imidazol-4-yl}-...)
Show SMILES COc1ccc(CCn2cnc(c2)-c2cc(ccn2)-c2nn[nH]c2C(F)(F)F)cc1
Show InChI InChI=1S/C20H17F3N6O/c1-30-15-4-2-13(3-5-15)7-9-29-11-17(25-12-29)16-10-14(6-8-24-16)18-19(20(21,22)23)27-28-26-18/h2-6,8,10-12H,7,9H2,1H3,(H,26,27,28)
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UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10174003 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM319678
PNG
(2-[5-(4-fluorophenyl)-1-methyl-1H-imidazol-4-yl]-4...)
Show SMILES Cn1cnc(c1-c1ccc(F)cc1)-c1cc(ccn1)-c1nn[nH]c1C(F)(F)F
Show InChI InChI=1S/C18H12F4N6/c1-28-9-24-15(16(28)10-2-4-12(19)5-3-10)13-8-11(6-7-23-13)14-17(18(20,21)22)26-27-25-14/h2-9H,1H3,(H,25,26,27)
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US Patent
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US10174003 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (human))
BDBM276042
PNG
(2-[5-[2-(cyclopropylmethoxy)-4-fluorophenyl]-1-met...)
Show SMILES Cn1cnc(c1-c1ccc(F)cc1OCC1CC1)-c1cc(ccn1)-c1c[nH]nn1
Show InChI InChI=1S/C21H19FN6O/c1-28-12-24-20(17-8-14(6-7-23-17)18-10-25-27-26-18)21(28)16-5-4-15(22)9-19(16)29-11-13-2-3-13/h4-10,12-13H,2-3,11H2,1H3,(H,25,26,27)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10174003 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (human))
BDBM276050
PNG
(2-[1-(3,4-dihydro-2H-chromen-4-ylmethyl)imidazol-4...)
Show SMILES C(C1CCOc2ccccc12)n1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1
Show InChI InChI=1S/C20H18N6O/c1-2-4-20-16(3-1)15(6-8-27-20)11-26-12-19(22-13-26)17-9-14(5-7-21-17)18-10-23-25-24-18/h1-5,7,9-10,12-13,15H,6,8,11H2,(H,23,24,25)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10174003 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (human))
BDBM276058
PNG
(2-[1-[(2,3-dichlorophenyl)methyl]imidazol-4-yl]-4-...)
Show SMILES Fc1[nH]nnc1-c1ccnc(c1)-c1cn(Cc2cccc(Cl)c2Cl)cn1
Show InChI InChI=1S/C17H11Cl2FN6/c18-12-3-1-2-11(15(12)19)7-26-8-14(22-9-26)13-6-10(4-5-21-13)16-17(20)24-25-23-16/h1-6,8-9H,7H2,(H,23,24,25)
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US Patent
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10174003 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (human))
BDBM319604
PNG
(2-[1-[[2-chloro-3- (trifluoromethyl)phenyl]methyl]...)
Show SMILES FC(F)(F)c1cccc(Cn2cnc(c2)-c2cc(ccn2)-c2c[nH]nn2)c1C(F)(F)F
Show InChI InChI=1S/C19H12F6N6/c20-18(21,22)13-3-1-2-12(17(13)19(23,24)25)8-31-9-16(27-10-31)14-6-11(4-5-26-14)15-7-28-30-29-15/h1-7,9-10H,8H2,(H,28,29,30)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10174003 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (human))
BDBM276075
PNG
(2-[1-(2-naphthalen-1-ylethyl)imidazol-4-yl]-4-[5-(...)
Show SMILES FC(F)(F)c1[nH]nnc1-c1ccnc(c1)-c1cn(CCc2cccc3ccccc23)cn1
Show InChI InChI=1S/C23H17F3N6/c24-23(25,26)22-21(29-31-30-22)17-8-10-27-19(12-17)20-13-32(14-28-20)11-9-16-6-3-5-15-4-1-2-7-18(15)16/h1-8,10,12-14H,9,11H2,(H,29,30,31)
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US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10174003 (2019)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%