BindingDB logo
myBDB logout

Patent code US10174028

Compile Data Set for Download or QSAR

Found 1162 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM284360
PNG
(4-(6-(4-(5-cyclopropyl- 1H-pyrazole-3- carbonyl)pi...)
Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCN(CC2)C(=O)c2cc([nH]n2)C2CC2)c2c(cnn2c1)C#N
Show InChI InChI=1S/C28H26N10O/c1-35-16-22(15-31-35)20-10-23(27-21(12-29)14-32-38(27)17-20)19-4-5-26(30-13-19)36-6-8-37(9-7-36)28(39)25-11-24(33-34-25)18-2-3-18/h4-5,10-11,13-18H,2-3,6-9H2,1H3,(H,33,34)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.5n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK a...


US Patent US10174028 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM284117
PNG
(US10023570, Example 127 | US10174027, Example 127)
Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCN(CC2)C(=O)Nc2ccccc2)c2c(cnn2c1)C#N
Show InChI InChI=1S/C28H25N9O/c1-34-18-23(17-31-34)21-13-25(27-22(14-29)16-32-37(27)19-21)20-7-8-26(30-15-20)35-9-11-36(12-10-35)28(38)33-24-5-3-2-4-6-24/h2-8,13,15-19H,9-12H2,1H3,(H,33,38)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.70n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK a...


US Patent US10174028 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM284119
PNG
(N-benzyl-4-(5-(3-cyano-6- (1-methyl-1H-pyrazol-4- ...)
Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCN(CC2)C(=O)NCc2ccccc2)c2c(cnn2c1)C#N
Show InChI InChI=1S/C29H27N9O/c1-35-19-25(18-33-35)23-13-26(28-24(14-30)17-34-38(28)20-23)22-7-8-27(31-16-22)36-9-11-37(12-10-36)29(39)32-15-21-5-3-2-4-6-21/h2-8,13,16-20H,9-12,15H2,1H3,(H,32,39)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.90n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK a...


US Patent US10174028 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM284552
PNG
(US10023570, Example 567 | US10174027, Example 567)
Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCC(CC2)S(C)(=O)=O)c2c(cnn2c1)C#N
Show InChI InChI=1S/C23H23N7O2S/c1-28-14-19(13-26-28)17-9-21(23-18(10-24)12-27-30(23)15-17)16-3-4-22(25-11-16)29-7-5-20(6-8-29)33(2,31)32/h3-4,9,11-15,20H,5-8H2,1-2H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 3.10n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK a...


US Patent US10174028 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM283931
PNG
(US10023570, Example 4 | US10174027, Example 4)
Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCN(CC2)C(=O)[C@@H](O)Cc2ccccc2)c2c(cnn2c1)C#N
Show InChI InChI=1S/C30H28N8O2/c1-35-19-25(18-33-35)23-14-26(29-24(15-31)17-34-38(29)20-23)22-7-8-28(32-16-22)36-9-11-37(12-10-36)30(40)27(39)13-21-5-3-2-4-6-21/h2-8,14,16-20,27,39H,9-13H2,1H3/t27-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 3.10n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK a...


US Patent US10174028 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM283981
PNG
((S)-4-(6-(4-(3- hydroxy-3- phenylpropanoyl)piperaz...)
Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCN(CC2)C(=O)C[C@H](O)c2ccccc2)c2c(cnn2c1)C#N
Show InChI InChI=1S/C30H28N8O2/c1-35-19-25(18-33-35)23-13-26(30-24(15-31)17-34-38(30)20-23)22-7-8-28(32-16-22)36-9-11-37(12-10-36)29(40)14-27(39)21-5-3-2-4-6-21/h2-8,13,16-20,27,39H,9-12,14H2,1H3/t27-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 3.60n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK a...


US Patent US10174028 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM284088
PNG
(4-(5-(3-cyano-6-(1-methyl-1H- pyrazol-4-yl)pyrazol...)
Show SMILES CCN(CC)C(=O)N1CCN(CC1)c1ccc(cn1)-c1cc(cn2ncc(C#N)c12)-c1cnn(C)c1
Show InChI InChI=1S/C26H29N9O/c1-4-32(5-2)26(36)34-10-8-33(9-11-34)24-7-6-19(14-28-24)23-12-20(22-16-29-31(3)17-22)18-35-25(23)21(13-27)15-30-35/h6-7,12,14-18H,4-5,8-11H2,1-3H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 3.60n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK a...


US Patent US10174028 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM284013
PNG
(US10023570, Example 23 | US10174027, Example 23)
Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCN(CC2)C(=O)C[C@H](N)c2ccccc2)c2c(cnn2c1)C#N
Show InChI InChI=1S/C30H29N9O/c1-36-19-25(18-34-36)23-13-26(30-24(15-31)17-35-39(30)20-23)22-7-8-28(33-16-22)37-9-11-38(12-10-37)29(40)14-27(32)21-5-3-2-4-6-21/h2-8,13,16-20,27H,9-12,14,32H2,1H3/t27-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 3.80n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK a...


US Patent US10174028 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM283980
PNG
((R)-4-(6-(4-(3- hydroxy-3- phenylpropanoyl)piperaz...)
Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCN(CC2)C(=O)C[C@@H](O)c2ccccc2)c2c(cnn2c1)C#N
Show InChI InChI=1S/C30H28N8O2/c1-35-19-25(18-33-35)23-13-26(30-24(15-31)17-34-38(30)20-23)22-7-8-28(32-16-22)36-9-11-37(12-10-36)29(40)14-27(39)21-5-3-2-4-6-21/h2-8,13,16-20,27,39H,9-12,14H2,1H3/t27-/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 3.90n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK a...


US Patent US10174028 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM284350
PNG
(4-(6-(4-(2-(5- fluoropyridin-2- yl)acetyl)piperazi...)
Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCN(CC2)C(=O)Cc2ccc(F)cn2)c2c(cnn2c1)C#N
Show InChI InChI=1S/C28H24FN9O/c1-35-17-22(15-33-35)20-10-25(28-21(12-30)14-34-38(28)18-20)19-2-5-26(32-13-19)36-6-8-37(9-7-36)27(39)11-24-4-3-23(29)16-31-24/h2-5,10,13-18H,6-9,11H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 3.90n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK a...


US Patent US10174028 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM284226
PNG
(1-(5-(3-cyano-6-(1- methyl-1H-pyrazol-4- yl)pyrazo...)
Show SMILES COC(CNC(=O)C1CCN(CC1)c1ccc(cn1)-c1cc(cn2ncc(C#N)c12)-c1cnn(C)c1)C(C)C
Show InChI InChI=1S/C29H34N8O2/c1-19(2)26(39-4)16-32-29(38)20-7-9-36(10-8-20)27-6-5-21(13-31-27)25-11-22(24-15-33-35(3)17-24)18-37-28(25)23(12-30)14-34-37/h5-6,11,13-15,17-20,26H,7-10,16H2,1-4H3,(H,32,38)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK a...


US Patent US10174028 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM284174
PNG
(US10023570, Example 184 | US10174028, Example 184)
Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCC(CC2)NC(=O)c2ccccc2)c2c(cnn2c1)C#N
Show InChI InChI=1S/C29H26N8O/c1-35-18-24(17-32-35)22-13-26(28-23(14-30)16-33-37(28)19-22)21-7-8-27(31-15-21)36-11-9-25(10-12-36)34-29(38)20-5-3-2-4-6-20/h2-8,13,15-19,25H,9-12H2,1H3,(H,34,38)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK a...


US Patent US10174028 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM284705
PNG
(US10023570, Example 740 | US10174027, Example 740)
Show SMILES COc1ccc(CN2CCN(CC2)c2ccc(cc2)-c2cc(cn3ncc(C#N)c23)-c2cnn(C)c2)cn1
Show InChI InChI=1S/C29H28N8O/c1-34-19-25(17-32-34)23-13-27(29-24(14-30)16-33-37(29)20-23)22-4-6-26(7-5-22)36-11-9-35(10-12-36)18-21-3-8-28(38-2)31-15-21/h3-8,13,15-17,19-20H,9-12,18H2,1-2H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK a...


US Patent US10174028 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM284355
PNG
(4-(6-(4-(2-(4- cyanophenyl)acetyl)pipera zin-1-yl)...)
Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCN(CC2)C(=O)Cc2ccc(cc2)C#N)c2c(cnn2c1)C#N
Show InChI InChI=1S/C30H25N9O/c1-36-19-26(18-34-36)24-13-27(30-25(15-32)17-35-39(30)20-24)23-6-7-28(33-16-23)37-8-10-38(11-9-37)29(40)12-21-2-4-22(14-31)5-3-21/h2-7,13,16-20H,8-12H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK a...


US Patent US10174028 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM284041
PNG
(4-(6-(4-(2,6- difluorobenzoyl)piperazin- 1-yl)pyri...)
Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCN(CC2)C(=O)c2c(F)cccc2F)c2c(cnn2c1)C#N
Show InChI InChI=1S/C28H22F2N8O/c1-35-16-21(15-33-35)19-11-22(27-20(12-31)14-34-38(27)17-19)18-5-6-25(32-13-18)36-7-9-37(10-8-36)28(39)26-23(29)3-2-4-24(26)30/h2-6,11,13-17H,7-10H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4.10n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK a...


US Patent US10174028 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM284555
PNG
(US10023570, Example 570 | US10174027, Example 570)
Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCC(Cc3ccccn3)CC2)c2c(cnn2c1)C#N
Show InChI InChI=1S/C28H26N8/c1-34-18-24(17-32-34)22-13-26(28-23(14-29)16-33-36(28)19-22)21-5-6-27(31-15-21)35-10-7-20(8-11-35)12-25-4-2-3-9-30-25/h2-6,9,13,15-20H,7-8,10-12H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4.20n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK a...


US Patent US10174028 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM284123
PNG
(4-(5-(3-cyano-6-(1-methyl- 1H-pyrazol-4- yl)pyrazo...)
Show SMILES CC(C)CNC(=O)N1CCN(CC1)c1ccc(cn1)-c1cc(cn2ncc(C#N)c12)-c1cnn(C)c1
Show InChI InChI=1S/C26H29N9O/c1-18(2)12-29-26(36)34-8-6-33(7-9-34)24-5-4-19(13-28-24)23-10-20(22-15-30-32(3)16-22)17-35-25(23)21(11-27)14-31-35/h4-5,10,13-18H,6-9,12H2,1-3H3,(H,29,36)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4.30n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK a...


US Patent US10174028 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM283987
PNG
((R)-6-(1-methyl-1H- pyrazol-4-yl)-4-(6-(4- (2- phe...)
Show SMILES C[C@@H](C(=O)N1CCN(CC1)c1ccc(cn1)-c1cc(cn2ncc(C#N)c12)-c1cnn(C)c1)c1ccccc1
Show InChI InChI=1S/C30H28N8O/c1-21(22-6-4-3-5-7-22)30(39)37-12-10-36(11-13-37)28-9-8-23(16-32-28)27-14-24(26-18-33-35(2)19-26)20-38-29(27)25(15-31)17-34-38/h3-9,14,16-21H,10-13H2,1-2H3/t21-/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4.40n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK a...


US Patent US10174028 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM284059
PNG
(4-(6-(4-benzoylpiperazin-1- yl)pyridin-3-yl)-6-(1-...)
Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCN(CC2)C(=O)c2ccccc2)c2c(cnn2c1)C#N
Show InChI InChI=1S/C28H24N8O/c1-33-18-24(17-31-33)22-13-25(27-23(14-29)16-32-36(27)19-22)21-7-8-26(30-15-21)34-9-11-35(12-10-34)28(37)20-5-3-2-4-6-20/h2-8,13,15-19H,9-12H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4.40n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK a...


US Patent US10174028 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM284068
PNG
(6-(1-methyl-1H-pyrazol-4- yl)-4-(6-(4-(2- phenylac...)
Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCN(CC2)C(=O)Cc2ccccc2)c2c(cnn2c1)C#N
Show InChI InChI=1S/C29H26N8O/c1-34-19-25(18-32-34)23-14-26(29-24(15-30)17-33-37(29)20-23)22-7-8-27(31-16-22)35-9-11-36(12-10-35)28(38)13-21-5-3-2-4-6-21/h2-8,14,16-20H,9-13H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4.40n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK a...


US Patent US10174028 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM284043
PNG
(US10023570, Example 53 | US10174027, Example 53)
Show SMILES CC(C)C[C@@H](O)C(=O)N1CCN(CC1)c1ccc(cn1)-c1cc(cn2ncc(C#N)c12)-c1cnn(C)c1
Show InChI InChI=1S/C27H30N8O2/c1-18(2)10-24(36)27(37)34-8-6-33(7-9-34)25-5-4-19(13-29-25)23-11-20(22-15-30-32(3)16-22)17-35-26(23)21(12-28)14-31-35/h4-5,11,13-18,24,36H,6-10H2,1-3H3/t24-/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4.40n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK a...


US Patent US10174028 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM284548
PNG
(US10023570, Example 563 | US10174027, Example 563)
Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCC(CC2)C(=O)NOCC2CC2)c2c(cnn2c1)C#N
Show InChI InChI=1S/C27H28N8O2/c1-33-15-23(14-30-33)21-10-24(26-22(11-28)13-31-35(26)16-21)20-4-5-25(29-12-20)34-8-6-19(7-9-34)27(36)32-37-17-18-2-3-18/h4-5,10,12-16,18-19H,2-3,6-9,17H2,1H3,(H,32,36)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4.40n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK a...


US Patent US10174028 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM284472
PNG
(US10023570, Example 482 | US10174027, Example 482)
Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCN(Cc3ccccc3)C(=O)C2)c2c(cnn2c1)C#N
Show InChI InChI=1S/C28H24N8O/c1-33-17-24(15-31-33)22-11-25(28-23(12-29)14-32-36(28)18-22)21-7-8-26(30-13-21)34-9-10-35(27(37)19-34)16-20-5-3-2-4-6-20/h2-8,11,13-15,17-18H,9-10,16,19H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4.40n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK a...


US Patent US10174028 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM284476
PNG
(US10023570, Example 489 | US10174027, Example 489)
Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CC3CC(C2)N3Cc2ccccc2)c2c(cnn2c1)C#N
Show InChI InChI=1S/C29H26N8/c1-34-16-24(14-32-34)22-9-27(29-23(11-30)13-33-37(29)17-22)21-7-8-28(31-12-21)35-18-25-10-26(19-35)36(25)15-20-5-3-2-4-6-20/h2-9,12-14,16-17,25-26H,10,15,18-19H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4.5n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK a...


US Patent US10174028 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM284129
PNG
(US10023570, Example 139 | US10174027, Example 139)
Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCN(Cc3ccccc3)CC2)c2c(cnn2c1)C#N
Show InChI InChI=1S/C28H26N8/c1-33-19-25(17-31-33)23-13-26(28-24(14-29)16-32-36(28)20-23)22-7-8-27(30-15-22)35-11-9-34(10-12-35)18-21-5-3-2-4-6-21/h2-8,13,15-17,19-20H,9-12,18H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4.5n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK a...


US Patent US10174028 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM320463
PNG
(4-(6-(4-(2-(2- fluorophenyl)-2- hydroxyacetyl)pipe...)
Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCN(CC2)C(=O)C(O)Cc2cccc(F)c2)c2c(cnn2c1)C#N
Show InChI InChI=1S/C30H27FN8O2/c1-36-18-24(17-34-36)22-13-26(29-23(14-32)16-35-39(29)19-22)21-5-6-28(33-15-21)37-7-9-38(10-8-37)30(41)27(40)12-20-3-2-4-25(31)11-20/h2-6,11,13,15-19,27,40H,7-10,12H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4.5n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK a...


US Patent US10174028 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM284232
PNG
(US10023570, Example 242 | US10174027, Example 242)
Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCC(CC2)C(=O)NCCC(F)(F)F)c2c(cnn2c1)C#N
Show InChI InChI=1S/C26H25F3N8O/c1-35-15-21(14-33-35)19-10-22(24-20(11-30)13-34-37(24)16-19)18-2-3-23(32-12-18)36-8-4-17(5-9-36)25(38)31-7-6-26(27,28)29/h2-3,10,12-17H,4-9H2,1H3,(H,31,38)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4.5n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK a...


US Patent US10174028 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM284464
PNG
(US10023570, Example 474 | US10174027, Example 474)
Show SMILES COc1ccc(CN2CCN(CC2)c2ccc(cn2)-c2cc(cn3ncc(C#N)c23)-c2cnn(C)c2)cn1
Show InChI InChI=1S/C28H27N9O/c1-34-18-24(16-32-34)22-11-25(28-23(12-29)15-33-37(28)19-22)21-4-5-26(30-14-21)36-9-7-35(8-10-36)17-20-3-6-27(38-2)31-13-20/h3-6,11,13-16,18-19H,7-10,17H2,1-2H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4.5n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK a...


US Patent US10174028 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM283978
PNG
(6-(1-methyl-1H- pyrazol-4-yl)-4-(6-(4- (2-(pyridin...)
Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCN(CC2)C(=O)Cc2ccccn2)c2c(cnn2c1)C#N
Show InChI InChI=1S/C28H25N9O/c1-34-18-23(17-32-34)21-12-25(28-22(14-29)16-33-37(28)19-21)20-5-6-26(31-15-20)35-8-10-36(11-9-35)27(38)13-24-4-2-3-7-30-24/h2-7,12,15-19H,8-11,13H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4.60n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK a...


US Patent US10174028 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM284431
PNG
(4-(6-(4-(2,6- difluorobenzyl)piperazin- 1-yl)pyrid...)
Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCN(Cc3c(F)cccc3F)CC2)c2c(cnn2c1)C#N
Show InChI InChI=1S/C28H24F2N8/c1-35-16-22(15-33-35)20-11-23(28-21(12-31)14-34-38(28)17-20)19-5-6-27(32-13-19)37-9-7-36(8-10-37)18-24-25(29)3-2-4-26(24)30/h2-6,11,13-17H,7-10,18H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4.70n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK a...


US Patent US10174028 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM284072
PNG
(US10023570, Example 82 | US10174027, Example 82)
Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCN(CC2)C(=O)[C@H](O)c2ccccc2)c2c(cnn2c1)C#N
Show InChI InChI=1S/C29H26N8O2/c1-34-18-24(17-32-34)22-13-25(27-23(14-30)16-33-37(27)19-22)21-7-8-26(31-15-21)35-9-11-36(12-10-35)29(39)28(38)20-5-3-2-4-6-20/h2-8,13,15-19,28,38H,9-12H2,1H3/t28-/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4.80n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK a...


US Patent US10174028 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM284629
PNG
(US10023570, Example 664 | US10174027, Example 664)
Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCN(CCS(=O)(=O)c3ccccc3)CC2)c2c(cnn2c1)C#N
Show InChI InChI=1S/C29H28N8O2S/c1-34-20-25(19-32-34)23-15-27(29-24(16-30)18-33-37(29)21-23)22-7-8-28(31-17-22)36-11-9-35(10-12-36)13-14-40(38,39)26-5-3-2-4-6-26/h2-8,15,17-21H,9-14H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4.90n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK a...


US Patent US10174028 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM284441
PNG
(4-(6-(4-(2- methoxybenzyl)piperazin- 1-yl)pyridin-...)
Show SMILES COc1ccccc1CN1CCN(CC1)c1ccc(cn1)-c1cc(cn2ncc(C#N)c12)-c1cnn(C)c1
Show InChI InChI=1S/C29H28N8O/c1-34-18-25(17-32-34)23-13-26(29-24(14-30)16-33-37(29)20-23)21-7-8-28(31-15-21)36-11-9-35(10-12-36)19-22-5-3-4-6-27(22)38-2/h3-8,13,15-18,20H,9-12,19H2,1-2H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4.90n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK a...


US Patent US10174028 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM283979
PNG
((S)-4-(6-(4-(2- hydroxy-2- phenylacetyl)piperazin-...)
Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCN(CC2)C(=O)[C@@H](O)c2ccccc2)c2c(cnn2c1)C#N
Show InChI InChI=1S/C29H26N8O2/c1-34-18-24(17-32-34)22-13-25(27-23(14-30)16-33-37(27)19-22)21-7-8-26(31-15-21)35-9-11-36(12-10-35)29(39)28(38)20-5-3-2-4-6-20/h2-8,13,15-19,28,38H,9-12H2,1H3/t28-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4.90n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK a...


US Patent US10174028 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM284015
PNG
(6-(1-methyl-1H-pyrazol-4- yl)-4-(6-(4-(1- phenylcy...)
Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCN(CC2)C(=O)C2(CC2)c2ccccc2)c2c(cnn2c1)C#N
Show InChI InChI=1S/C31H28N8O/c1-36-20-25(19-34-36)23-15-27(29-24(16-32)18-35-39(29)21-23)22-7-8-28(33-17-22)37-11-13-38(14-12-37)30(40)31(9-10-31)26-5-3-2-4-6-26/h2-8,15,17-21H,9-14H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 5n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK a...


US Patent US10174028 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM284526
PNG
(4-(6-(2,9- diazaspiro[5.5]undecan-2- yl)pyridin-3-...)
Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCCC3(CCNCC3)C2)c2c(cnn2c1)C#N
Show InChI InChI=1S/C26H28N8/c1-32-16-22(15-30-32)20-11-23(25-21(12-27)14-31-34(25)17-20)19-3-4-24(29-13-19)33-10-2-5-26(18-33)6-8-28-9-7-26/h3-4,11,13-17,28H,2,5-10,18H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 5.10n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK a...


US Patent US10174028 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM284348
PNG
(6-(1-methyl-1H-pyrazol- 4-yl)-4-(6-(4-(2- morpholi...)
Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCN(CC2)C(=O)c2ccccc2N2CCOCC2)c2c(cnn2c1)C#N
Show InChI InChI=1S/C32H31N9O2/c1-37-21-26(20-35-37)24-16-28(31-25(17-33)19-36-41(31)22-24)23-6-7-30(34-18-23)39-8-10-40(11-9-39)32(42)27-4-2-3-5-29(27)38-12-14-43-15-13-38/h2-7,16,18-22H,8-15H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 5.10n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK a...


US Patent US10174028 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM284189
PNG
(US10023570, Example 199 | US10174028, Example 199)
Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2[C@H]3CC[C@@H]2C[C@H](O)C3)c2c(cnn2c1)C#N
Show InChI InChI=1S/C24H23N7O/c1-29-13-18(12-27-29)16-6-22(24-17(9-25)11-28-30(24)14-16)15-2-5-23(26-10-15)31-19-3-4-20(31)8-21(32)7-19/h2,5-6,10-14,19-21,32H,3-4,7-8H2,1H3/t19-,20+,21+
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 5.10n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK a...


US Patent US10174028 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM284567
PNG
(US10023570, Example 586 | US10174027, Example 586)
Show SMILES FC(F)n1cc(cn1)-c1cc(-c2ccc(nc2)N2CCN(Cc3ccccn3)CC2)c2c(cnn2c1)C#N
Show InChI InChI=1S/C27H23F2N9/c28-27(29)38-17-22(15-34-38)20-11-24(26-21(12-30)14-33-37(26)16-20)19-4-5-25(32-13-19)36-9-7-35(8-10-36)18-23-3-1-2-6-31-23/h1-6,11,13-17,27H,7-10,18H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 5.20n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK a...


US Patent US10174028 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM284080
PNG
(4-(6-(4- (isobutylsulfonyl)piperazin- 1-yl)pyridin...)
Show SMILES CC(C)CS(=O)(=O)N1CCN(CC1)c1ccc(cn1)-c1cc(cn2ncc(C#N)c12)-c1cnn(C)c1
Show InChI InChI=1S/C25H28N8O2S/c1-18(2)17-36(34,35)32-8-6-31(7-9-32)24-5-4-19(12-27-24)23-10-20(22-14-28-30(3)15-22)16-33-25(23)21(11-26)13-29-33/h4-5,10,12-16,18H,6-9,17H2,1-3H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 5.20n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK a...


US Patent US10174028 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM284527
PNG
(4-(6-(1,8- diazaspiro[4.5]decan-8- yl)pyridin-3-yl...)
Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCC3(CCCN3)CC2)c2c(cnn2c1)C#N
Show InChI InChI=1S/C25H26N8/c1-31-16-21(15-29-31)19-11-22(24-20(12-26)14-30-33(24)17-19)18-3-4-23(27-13-18)32-9-6-25(7-10-32)5-2-8-28-25/h3-4,11,13-17,28H,2,5-10H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 5.20n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK a...


US Patent US10174028 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM320540
PNG
(US10174027, Example 87)
Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCN(CC2)S(=O)(=O)CC2CC2)c2c(cnn2c1)C#N
Show InChI InChI=1S/C25H26N8O2S/c1-30-15-22(14-28-30)20-10-23(25-21(11-26)13-29-33(25)16-20)19-4-5-24(27-12-19)31-6-8-32(9-7-31)36(34,35)17-18-2-3-18/h4-5,10,12-16,18H,2-3,6-9,17H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 5.30n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK a...


US Patent US10174028 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM283982
PNG
((R)-4-(6-(4-(2- hydroxy-3- phenylpropanoyl)piperaz...)
Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCN(CC2)C(=O)[C@H](O)Cc2ccccc2)c2c(cnn2c1)C#N
Show InChI InChI=1S/C30H28N8O2/c1-35-19-25(18-33-35)23-14-26(29-24(15-31)17-34-38(29)20-23)22-7-8-28(32-16-22)36-9-11-37(12-10-36)30(40)27(39)13-21-5-3-2-4-6-21/h2-8,14,16-20,27,39H,9-13H2,1H3/t27-/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 5.30n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK a...


US Patent US10174028 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM284128
PNG
(US10023570, Example 138 | US10174027, Example 138)
Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCN(CC2)S(=O)(=O)N2CCCC2)c2c(cnn2c1)C#N
Show InChI InChI=1S/C25H27N9O2S/c1-30-17-22(16-28-30)20-12-23(25-21(13-26)15-29-34(25)18-20)19-4-5-24(27-14-19)31-8-10-33(11-9-31)37(35,36)32-6-2-3-7-32/h4-5,12,14-18H,2-3,6-11H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 5.40n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK a...


US Patent US10174028 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM284379
PNG
(4-(6-(4-(3- ethylpyrrolidine-1- carbonyl)piperazin...)
Show SMILES CCC1CCN(C1)C(=O)N1CCN(CC1)c1ccc(cn1)-c1cc(cn2ncc(C#N)c12)-c1cnn(C)c1
Show InChI InChI=1S/C28H31N9O/c1-3-20-6-7-36(17-20)28(38)35-10-8-34(9-11-35)26-5-4-21(14-30-26)25-12-22(24-16-31-33(2)18-24)19-37-27(25)23(13-29)15-32-37/h4-5,12,14-16,18-20H,3,6-11,17H2,1-2H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 5.40n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK a...


US Patent US10174028 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM284374
PNG
(4-(6-(4-(6,6-dimethyl- 3- azabicyclo[3.1.0]hexane-...)
Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCN(CC2)C(=O)N2CC3C(C2)C3(C)C)c2c(cnn2c1)C#N
Show InChI InChI=1S/C29H31N9O/c1-29(2)24-17-37(18-25(24)29)28(39)36-8-6-35(7-9-36)26-5-4-19(12-31-26)23-10-20(22-14-32-34(3)15-22)16-38-27(23)21(11-30)13-33-38/h4-5,10,12-16,24-25H,6-9,17-18H2,1-3H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 5.5n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK a...


US Patent US10174028 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM284124
PNG
(4-(5-(3-cyano-6-(1-methyl- 1H-pyrazol-4- yl)pyrazo...)
Show SMILES CCNC(=O)N1CCN(CC1)c1ccc(cn1)-c1cc(cn2ncc(C#N)c12)-c1cnn(C)c1
Show InChI InChI=1S/C24H25N9O/c1-3-26-24(34)32-8-6-31(7-9-32)22-5-4-17(12-27-22)21-10-18(20-14-28-30(2)15-20)16-33-23(21)19(11-25)13-29-33/h4-5,10,12-16H,3,6-9H2,1-2H3,(H,26,34)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 5.5n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK a...


US Patent US10174028 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM284051
PNG
((S)-6-(1-methyl-1H-pyrazol- 4-yl)-4-(6-(4-(3,3,3- ...)
Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCN(CC2)C(=O)[C@H](O)C(F)(F)F)c2c(cnn2c1)C#N
Show InChI InChI=1S/C24H21F3N8O2/c1-32-13-18(12-30-32)16-8-19(21-17(9-28)11-31-35(21)14-16)15-2-3-20(29-10-15)33-4-6-34(7-5-33)23(37)22(36)24(25,26)27/h2-3,8,10-14,22,36H,4-7H2,1H3/t22-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 5.5n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK a...


US Patent US10174028 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM284440
PNG
(4-(6-(4-(3- methoxybenzyl)piperazin- 1-yl)pyridin-...)
Show SMILES COc1cccc(CN2CCN(CC2)c2ccc(cn2)-c2cc(cn3ncc(C#N)c23)-c2cnn(C)c2)c1
Show InChI InChI=1S/C29H28N8O/c1-34-19-25(17-32-34)23-13-27(29-24(14-30)16-33-37(29)20-23)22-6-7-28(31-15-22)36-10-8-35(9-11-36)18-21-4-3-5-26(12-21)38-2/h3-7,12-13,15-17,19-20H,8-11,18H2,1-2H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 5.5n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK a...


US Patent US10174028 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM284233
PNG
(US10023570, Example 243 | US10174027, Example 243)
Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCC(CC2)C(=O)NCC(F)(F)F)c2c(cnn2c1)C#N
Show InChI InChI=1S/C25H23F3N8O/c1-34-13-20(12-32-34)18-8-21(23-19(9-29)11-33-36(23)14-18)17-2-3-22(30-10-17)35-6-4-16(5-7-35)24(37)31-15-25(26,27)28/h2-3,8,10-14,16H,4-7,15H2,1H3,(H,31,37)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 5.60n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK a...


US Patent US10174028 (2019)

More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 1162 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%