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Patent code US10174035

Compile Data Set for Download or QSAR

Found 234 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM320554
PNG
(US10174035, Compound 97 | [4-(Dimethylamino)piperi...)
Show SMILES CN(C)C1CCN(CC1)C(=O)c1nc2c(N3CCOCC3)c(F)c(nc2[nH]1)-c1cn(C)nc1C
Show InChI InChI=1S/C23H31FN8O2/c1-14-16(13-30(4)28-14)18-17(24)20(31-9-11-34-12-10-31)19-21(25-18)27-22(26-19)23(33)32-7-5-15(6-8-32)29(2)3/h13,15H,5-12H2,1-4H3,(H,25,26,27)
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n/an/a 3n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...


US Patent US10174035 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM320553
PNG
(US10174035, Compound 96 | [5-(1,3-Dimethyl-1H-pyra...)
Show SMILES Cc1nn(C)cc1-c1nc2[nH]c(nc2c(N2CCOCC2)c1F)C(=O)N1CCC(CC1)N1CCOCC1
Show InChI InChI=1S/C25H33FN8O3/c1-16-18(15-31(2)30-16)20-19(26)22(33-9-13-37-14-10-33)21-23(27-20)29-24(28-21)25(35)34-5-3-17(4-6-34)32-7-11-36-12-8-32/h15,17H,3-14H2,1-2H3,(H,27,28,29)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...


US Patent US10174035 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM320554
PNG
(US10174035, Compound 97 | [4-(Dimethylamino)piperi...)
Show SMILES CN(C)C1CCN(CC1)C(=O)c1nc2c(N3CCOCC3)c(F)c(nc2[nH]1)-c1cn(C)nc1C
Show InChI InChI=1S/C23H31FN8O2/c1-14-16(13-30(4)28-14)18-17(24)20(31-9-11-34-12-10-31)19-21(25-18)27-22(26-19)23(33)32-7-5-15(6-8-32)29(2)3/h13,15H,5-12H2,1-4H3,(H,25,26,27)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...


US Patent US10174035 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM320544
PNG
(US10174035, Compound 87 | [5-(1,3-Dimethyl-1H-pyra...)
Show SMILES Cc1nn(C)cc1-c1nc2n(C)c(nc2c(N2CCOCC2)c1F)C(=O)N1CCC(CC1)N1CCOCC1
Show InChI InChI=1S/C26H35FN8O3/c1-17-19(16-31(2)30-17)21-20(27)23(34-10-14-38-15-11-34)22-24(28-21)32(3)25(29-22)26(36)35-6-4-18(5-7-35)33-8-12-37-13-9-33/h16,18H,4-15H2,1-3H3
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...


US Patent US10174035 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM320544
PNG
(US10174035, Compound 87 | [5-(1,3-Dimethyl-1H-pyra...)
Show SMILES Cc1nn(C)cc1-c1nc2n(C)c(nc2c(N2CCOCC2)c1F)C(=O)N1CCC(CC1)N1CCOCC1
Show InChI InChI=1S/C26H35FN8O3/c1-17-19(16-31(2)30-17)21-20(27)23(34-10-14-38-15-11-34)22-24(28-21)32(3)25(29-22)26(36)35-6-4-18(5-7-35)33-8-12-37-13-9-33/h16,18H,4-15H2,1-3H3
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...


US Patent US10174035 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM320591
PNG
(US10174035, Compound 134 | [4-(Morpholin-4-yl)pipe...)
Show SMILES FC(F)(F)c1n[nH]cc1-c1cc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CCC(CC1)N1CCOCC1
Show InChI InChI=1S/C24H27F3N8O3/c25-24(26,27)20-16(14-28-32-20)17-13-18(34-7-11-38-12-8-34)19-21(29-17)31-22(30-19)23(36)35-3-1-15(2-4-35)33-5-9-37-10-6-33/h13-15H,1-12H2/b17-16-
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...


US Patent US10174035 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM320551
PNG
(US10174035, Compound 94 | [5-(1,3-Dimethyl-1H-pyra...)
Show SMILES Cc1nn(C)cc1-c1cc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CCC(CC1)N1CCOCC1
Show InChI InChI=1S/C25H34N8O3/c1-17-19(16-30(2)29-17)20-15-21(32-9-13-36-14-10-32)22-23(26-20)28-24(27-22)25(34)33-5-3-18(4-6-33)31-7-11-35-12-8-31/h15-16,18H,3-14H2,1-2H3,(H,26,27,28)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...


US Patent US10174035 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM320551
PNG
(US10174035, Compound 94 | [5-(1,3-Dimethyl-1H-pyra...)
Show SMILES Cc1nn(C)cc1-c1cc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CCC(CC1)N1CCOCC1
Show InChI InChI=1S/C25H34N8O3/c1-17-19(16-30(2)29-17)20-15-21(32-9-13-36-14-10-32)22-23(26-20)28-24(27-22)25(34)33-5-3-18(4-6-33)31-7-11-35-12-8-31/h15-16,18H,3-14H2,1-2H3,(H,26,27,28)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...


US Patent US10174035 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM320580
PNG
(US10174035, Compound 123 | {6-Fluoro-7-(morpholin-...)
Show SMILES Fc1c(nc2[nH]c(nc2c1N1CCOCC1)C(=O)N1CCC(CC1)N1CCOCC1)-c1c[nH]nc1C(F)(F)F
Show InChI InChI=1S/C24H26F4N8O3/c25-16-17(15-13-29-33-20(15)24(26,27)28)30-21-18(19(16)35-7-11-39-12-8-35)31-22(32-21)23(37)36-3-1-14(2-4-36)34-5-9-38-10-6-34/h13-14H,1-12H2/b17-15-
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...


US Patent US10174035 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM320576
PNG
(US10174035, Compound 119 | {3-[(2R,6S)-2,6-dimethy...)
Show SMILES C[C@H]1CN(C[C@@H](C)O1)C1CN(C1)C(=O)c1nc2c(cc(nc2[nH]1)-c1cnn(C)c1)N1CCOCC1
Show InChI InChI=1S/C24H32N8O3/c1-15-10-31(11-16(2)35-15)18-13-32(14-18)24(33)23-27-21-20(30-4-6-34-7-5-30)8-19(26-22(21)28-23)17-9-25-29(3)12-17/h8-9,12,15-16,18H,4-7,10-11,13-14H2,1-3H3,(H,26,27,28)/t15-,16+
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...


US Patent US10174035 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM320541
PNG
(US10174035, Compound 84 | [5-(1,3-Dimethyl-1H-pyra...)
Show SMILES Cc1nn(C)cc1-c1nc2[nH]c(nc2c(N2CCOCC2)c1F)C(=O)N1CCC(CC1)C(C)(C)O
Show InChI InChI=1S/C24H32FN7O3/c1-14-16(13-30(4)29-14)18-17(25)20(31-9-11-35-12-10-31)19-21(26-18)28-22(27-19)23(33)32-7-5-15(6-8-32)24(2,3)34/h13,15,34H,5-12H2,1-4H3,(H,26,27,28)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...


US Patent US10174035 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM320555
PNG
(US10174035, Compound 98 | [6-Fluoro-5-(1-methyl-1H...)
Show SMILES Cn1cc(cn1)-c1nc2[nH]c(nc2c(N2CCOCC2)c1F)C(=O)N1CCC(CC1)N1CCOCC1
Show InChI InChI=1S/C24H31FN8O3/c1-30-15-16(14-26-30)19-18(25)21(32-8-12-36-13-9-32)20-22(27-19)29-23(28-20)24(34)33-4-2-17(3-5-33)31-6-10-35-11-7-31/h14-15,17H,2-13H2,1H3,(H,27,28,29)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...


US Patent US10174035 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM320555
PNG
(US10174035, Compound 98 | [6-Fluoro-5-(1-methyl-1H...)
Show SMILES Cn1cc(cn1)-c1nc2[nH]c(nc2c(N2CCOCC2)c1F)C(=O)N1CCC(CC1)N1CCOCC1
Show InChI InChI=1S/C24H31FN8O3/c1-30-15-16(14-26-30)19-18(25)21(32-8-12-36-13-9-32)20-22(27-19)29-23(28-20)24(34)33-4-2-17(3-5-33)31-6-10-35-11-7-31/h14-15,17H,2-13H2,1H3,(H,27,28,29)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...


US Patent US10174035 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM320570
PNG
(US10174035, Compound 113 | {4-[cis-2,6-Dimethylmor...)
Show SMILES C[C@H]1CN(C[C@@H](C)O1)C1CCN(CC1)C(=O)c1nc2c(cc(nc2[nH]1)-c1cn(C)nc1C)N1CCOCC1
Show InChI InChI=1S/C27H38N8O3/c1-17-14-35(15-18(2)38-17)20-5-7-34(8-6-20)27(36)26-29-24-23(33-9-11-37-12-10-33)13-22(28-25(24)30-26)21-16-32(4)31-19(21)3/h13,16-18,20H,5-12,14-15H2,1-4H3,(H,28,29,30)/t17-,18+
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...


US Patent US10174035 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM320570
PNG
(US10174035, Compound 113 | {4-[cis-2,6-Dimethylmor...)
Show SMILES C[C@H]1CN(C[C@@H](C)O1)C1CCN(CC1)C(=O)c1nc2c(cc(nc2[nH]1)-c1cn(C)nc1C)N1CCOCC1
Show InChI InChI=1S/C27H38N8O3/c1-17-14-35(15-18(2)38-17)20-5-7-34(8-6-20)27(36)26-29-24-23(33-9-11-37-12-10-33)13-22(28-25(24)30-26)21-16-32(4)31-19(21)3/h13,16-18,20H,5-12,14-15H2,1-4H3,(H,28,29,30)/t17-,18+
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...


US Patent US10174035 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM320537
PNG
(US10174035, Compound 81 | [6-Fluoro-5-(1-methyl-1H...)
Show SMILES Cn1cc(cn1)-c1nc2[nH]c(nc2c(N2CCOCC2)c1F)C(=O)N1CCN(CC1)C1CCOCC1
Show InChI InChI=1S/C24H31FN8O3/c1-30-15-16(14-26-30)19-18(25)21(32-8-12-36-13-9-32)20-22(27-19)29-23(28-20)24(34)33-6-4-31(5-7-33)17-2-10-35-11-3-17/h14-15,17H,2-13H2,1H3,(H,27,28,29)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...


US Patent US10174035 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM320529
PNG
(4-(1-{[6-(Morpholin-4-yl)-2-(1H-pyrazol-4-yl)-9H-p...)
Show SMILES O=C(N1CCC(CC1)N1CCOCC1=O)c1nc2c(nc(nc2[nH]1)-c1cn[nH]c1)N1CCOCC1
Show InChI InChI=1S/C22H25N9O4/c32-16-13-35-10-7-31(16)15-1-3-30(4-2-15)22(33)20-25-17-19(27-20)26-18(14-11-23-24-12-14)28-21(17)29-5-8-34-9-6-29/h11-12,15H,1-10,13H2
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...


US Patent US10174035 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM320532
PNG
(4-(1-{[5-(1-Methyl-1H-pyrazol-4-yl)-7-(morpholin-4...)
Show SMILES Cn1cc(cn1)-c1cc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CCC(CC1)N1CCOCC1=O
Show InChI InChI=1S/C24H30N8O4/c1-29-14-16(13-25-29)18-12-19(30-6-9-35-10-7-30)21-22(26-18)28-23(27-21)24(34)31-4-2-17(3-5-31)32-8-11-36-15-20(32)33/h12-14,17H,2-11,15H2,1H3,(H,26,27,28)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...


US Patent US10174035 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM320462
PNG
(US10174035, Compound 9 | [2-(1,3-Dimethyl-1H-pyraz...)
Show SMILES Cc1nn(C)cc1-c1nc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CCN(CC1)C1CCOCC1
Show InChI InChI=1S/C24H33N9O3/c1-16-18(15-30(2)29-16)20-26-21-19(23(28-20)32-9-13-36-14-10-32)25-22(27-21)24(34)33-7-5-31(6-8-33)17-3-11-35-12-4-17/h15,17H,3-14H2,1-2H3,(H,25,26,27,28)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...


US Patent US10174035 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM320496
PNG
(US10174035, Compound 42 | [4-(Morpholin-4-yl)piper...)
Show SMILES O=C(N1CCC(CC1)N1CCOCC1)c1nc2c(nc(nc2[nH]1)-c1cn[nH]c1)N1CCOCC1
Show InChI InChI=1S/C22H27N9O3/c32-22(31-3-1-16(2-4-31)29-5-9-33-10-6-29)20-25-17-19(27-20)26-18(15-13-23-24-14-15)28-21(17)30-7-11-34-12-8-30/h13-14,16H,1-12H2
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...


US Patent US10174035 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM320586
PNG
(1-Methyl-4-(1-{[5-(1-methyl-1H-pyrazol-4-yl)-7-(mo...)
Show SMILES CN1CCN(CC1=O)C1CN(C1)C(=O)c1nc2c(cc(nc2[nH]1)-c1cnn(C)c1)N1CCOCC1
Show InChI InChI=1S/C23H29N9O3/c1-28-3-4-31(14-19(28)33)16-12-32(13-16)23(34)22-26-20-18(30-5-7-35-8-6-30)9-17(25-21(20)27-22)15-10-24-29(2)11-15/h9-11,16H,3-8,12-14H2,1-2H3,(H,25,26,27)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...


US Patent US10174035 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM320587
PNG
(1-Methyl-4-(1-{[2-(1-methyl-1H-pyrazol-4-yl)-6-(mo...)
Show SMILES CN1CCN(CC1=O)C1CN(C1)C(=O)c1nc2c(nc(nc2[nH]1)-c1cnn(C)c1)N1CCOCC1
Show InChI InChI=1S/C22H28N10O3/c1-28-3-4-31(13-16(28)33)15-11-32(12-15)22(34)20-24-17-19(26-20)25-18(14-9-23-29(2)10-14)27-21(17)30-5-7-35-8-6-30/h9-10,15H,3-8,11-13H2,1-2H3,(H,24,25,26,27)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...


US Patent US10174035 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM320461
PNG
(2-(4-{[2-(1,3-Dimethyl-1H-pyrazol-4-yl)-6-(morphol...)
Show SMILES Cc1nn(C)cc1-c1nc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CCN(CC1)C(C)(C)C(N)=O
Show InChI InChI=1S/C23H32N10O3/c1-14-15(13-30(4)29-14)17-26-18-16(20(28-17)31-9-11-36-12-10-31)25-19(27-18)21(34)32-5-7-33(8-6-32)23(2,3)22(24)35/h13H,5-12H2,1-4H3,(H2,24,35)(H,25,26,27,28)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...


US Patent US10174035 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM320461
PNG
(2-(4-{[2-(1,3-Dimethyl-1H-pyrazol-4-yl)-6-(morphol...)
Show SMILES Cc1nn(C)cc1-c1nc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CCN(CC1)C(C)(C)C(N)=O
Show InChI InChI=1S/C23H32N10O3/c1-14-15(13-30(4)29-14)17-26-18-16(20(28-17)31-9-11-36-12-10-31)25-19(27-18)21(34)32-5-7-33(8-6-32)23(2,3)22(24)35/h13H,5-12H2,1-4H3,(H2,24,35)(H,25,26,27,28)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...


US Patent US10174035 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM320577
PNG
(US10174035, Compound 120 | [5-(1-Methyl-1H-pyrazol...)
Show SMILES Cn1cc(cn1)-c1cc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CC(C1)N1CCOCC1
Show InChI InChI=1S/C22H28N8O3/c1-27-12-15(11-23-27)17-10-18(29-4-8-33-9-5-29)19-20(24-17)26-21(25-19)22(31)30-13-16(14-30)28-2-6-32-7-3-28/h10-12,16H,2-9,13-14H2,1H3,(H,24,25,26)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...


US Patent US10174035 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM320538
PNG
(2-(4-{[6-Fluoro-5-(1-methyl-1H-pyrazol-4-yl)-7-(mo...)
Show SMILES Cn1cc(cn1)-c1nc2[nH]c(nc2c(N2CCOCC2)c1F)C(=O)N1CCN(CC1)C(C)(C)C(N)=O
Show InChI InChI=1S/C23H30FN9O3/c1-23(2,22(25)35)33-6-4-32(5-7-33)21(34)20-28-17-18(31-8-10-36-11-9-31)15(24)16(27-19(17)29-20)14-12-26-30(3)13-14/h12-13H,4-11H2,1-3H3,(H2,25,35)(H,27,28,29)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...


US Patent US10174035 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM320521
PNG
(9-Methyl-2-(1-methyl-1H-pyrazol-4-yl)-6-(morpholin...)
Show SMILES Cn1cc(cn1)-c1nc(N2CCOCC2)c2nc(C(=O)NCCCN3CCOCC3)n(C)c2n1
Show InChI InChI=1S/C22H31N9O3/c1-28-15-16(14-24-28)18-26-19-17(20(27-18)31-8-12-34-13-9-31)25-21(29(19)2)22(32)23-4-3-5-30-6-10-33-11-7-30/h14-15H,3-13H2,1-2H3,(H,23,32)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...


US Patent US10174035 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM320458
PNG
(US10174035, Compound 5 | {4-[cis-2,6-Dimethylmorph...)
Show SMILES C[C@H]1CN(C[C@@H](C)O1)C1CCN(CC1)C(=O)c1nc2c(nc(nc2[nH]1)-c1cnn(C)c1)N1CCOCC1
Show InChI InChI=1S/C25H35N9O3/c1-16-13-34(14-17(2)37-16)19-4-6-33(7-5-19)25(35)23-27-20-22(29-23)28-21(18-12-26-31(3)15-18)30-24(20)32-8-10-36-11-9-32/h12,15-17,19H,4-11,13-14H2,1-3H3,(H,27,28,29,30)/t16-,17+
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...


US Patent US10174035 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM320521
PNG
(9-Methyl-2-(1-methyl-1H-pyrazol-4-yl)-6-(morpholin...)
Show SMILES Cn1cc(cn1)-c1nc(N2CCOCC2)c2nc(C(=O)NCCCN3CCOCC3)n(C)c2n1
Show InChI InChI=1S/C22H31N9O3/c1-28-15-16(14-24-28)18-26-19-17(20(27-18)31-8-12-34-13-9-31)25-21(29(19)2)22(32)23-4-3-5-30-6-10-33-11-7-30/h14-15H,3-13H2,1-2H3,(H,23,32)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...


US Patent US10174035 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM320458
PNG
(US10174035, Compound 5 | {4-[cis-2,6-Dimethylmorph...)
Show SMILES C[C@H]1CN(C[C@@H](C)O1)C1CCN(CC1)C(=O)c1nc2c(nc(nc2[nH]1)-c1cnn(C)c1)N1CCOCC1
Show InChI InChI=1S/C25H35N9O3/c1-16-13-34(14-17(2)37-16)19-4-6-33(7-5-19)25(35)23-27-20-22(29-23)28-21(18-12-26-31(3)15-18)30-24(20)32-8-10-36-11-9-32/h12,15-17,19H,4-11,13-14H2,1-3H3,(H,27,28,29,30)/t16-,17+
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...


US Patent US10174035 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM320538
PNG
(2-(4-{[6-Fluoro-5-(1-methyl-1H-pyrazol-4-yl)-7-(mo...)
Show SMILES Cn1cc(cn1)-c1nc2[nH]c(nc2c(N2CCOCC2)c1F)C(=O)N1CCN(CC1)C(C)(C)C(N)=O
Show InChI InChI=1S/C23H30FN9O3/c1-23(2,22(25)35)33-6-4-32(5-7-33)21(34)20-28-17-18(31-8-10-36-11-9-31)15(24)16(27-19(17)29-20)14-12-26-30(3)13-14/h12-13H,4-11H2,1-3H3,(H2,25,35)(H,27,28,29)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...


US Patent US10174035 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM320519
PNG
(US10174035, Compound 65 | {4-[cis-2,6-Dimethylmorp...)
Show SMILES C[C@H]1CN(C[C@@H](C)O1)C1CCN(CC1)C(=O)c1nc2c(nc(nc2[nH]1)-c1cn[nH]c1)N1CCOCC1
Show InChI InChI=1S/C24H31N9O3/c1-15-13-33(14-16(2)36-15)18-3-5-32(6-4-18)24(34)22-27-19-21(29-22)28-20(17-11-25-26-12-17)30-23(19)31-7-9-35-10-8-31/h11-12,15-16,18H,3-10,13-14H2,1-2H3/t15-,16+
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...


US Patent US10174035 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM320471
PNG
(US10174035, Compound 17 | {2-[1-Methyl-3-(trifluor...)
Show SMILES Cn1cc(c(n1)C(F)(F)F)-c1nc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CCC(CC1)N1CCOCC1
Show InChI InChI=1S/C24H30F3N9O3/c1-33-14-16(18(32-33)24(25,26)27)19-29-20-17(22(31-19)35-8-12-39-13-9-35)28-21(30-20)23(37)36-4-2-15(3-5-36)34-6-10-38-11-7-34/h14-15H,2-13H2,1H3,(H,28,29,30,31)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...


US Patent US10174035 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM320519
PNG
(US10174035, Compound 65 | {4-[cis-2,6-Dimethylmorp...)
Show SMILES C[C@H]1CN(C[C@@H](C)O1)C1CCN(CC1)C(=O)c1nc2c(nc(nc2[nH]1)-c1cn[nH]c1)N1CCOCC1
Show InChI InChI=1S/C24H31N9O3/c1-15-13-33(14-16(2)36-15)18-3-5-32(6-4-18)24(34)22-27-19-21(29-22)28-20(17-11-25-26-12-17)30-23(19)31-7-9-35-10-8-31/h11-12,15-16,18H,3-10,13-14H2,1-2H3/t15-,16+
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...


US Patent US10174035 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM320473
PNG
(US10174035, Compound 19 | [4-(Morpholin-4-yl)piper...)
Show SMILES FC(F)(F)c1n[nH]cc1-c1nc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CCC(CC1)N1CCOCC1
Show InChI InChI=1S/C23H26F3N9O3/c24-23(25,26)17-15(13-27-32-17)18-29-19-16(21(31-18)34-7-11-38-12-8-34)28-20(30-19)22(36)35-3-1-14(2-4-35)33-5-9-37-10-6-33/h13-14H,1-12H2/b18-15+
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...


US Patent US10174035 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM320473
PNG
(US10174035, Compound 19 | [4-(Morpholin-4-yl)piper...)
Show SMILES FC(F)(F)c1n[nH]cc1-c1nc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CCC(CC1)N1CCOCC1
Show InChI InChI=1S/C23H26F3N9O3/c24-23(25,26)17-15(13-27-32-17)18-29-19-16(21(31-18)34-7-11-38-12-8-34)28-20(30-19)22(36)35-3-1-14(2-4-35)33-5-9-37-10-6-33/h13-14H,1-12H2/b18-15+
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...


US Patent US10174035 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM320534
PNG
(US10174035, Compound 78 | [5-(1-Methyl-1H-pyrazol-...)
Show SMILES Cn1cc(cn1)-c1cc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CCC2(COC2)CC1
Show InChI InChI=1S/C22H27N7O3/c1-27-12-15(11-23-27)16-10-17(28-6-8-31-9-7-28)18-19(24-16)26-20(25-18)21(30)29-4-2-22(3-5-29)13-32-14-22/h10-12H,2-9,13-14H2,1H3,(H,24,25,26)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...


US Patent US10174035 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM320534
PNG
(US10174035, Compound 78 | [5-(1-Methyl-1H-pyrazol-...)
Show SMILES Cn1cc(cn1)-c1cc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CCC2(COC2)CC1
Show InChI InChI=1S/C22H27N7O3/c1-27-12-15(11-23-27)16-10-17(28-6-8-31-9-7-28)18-19(24-16)26-20(25-18)21(30)29-4-2-22(3-5-29)13-32-14-22/h10-12H,2-9,13-14H2,1H3,(H,24,25,26)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...


US Patent US10174035 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM320512
PNG
(US10174035, Compound 58 | [2-(1-Methyl-1H-pyrazol-...)
Show SMILES Cn1cc(cn1)-c1nc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CCC(CC1)N1CCOCC1
Show InChI InChI=1S/C23H31N9O3/c1-29-15-16(14-24-29)19-26-20-18(22(28-19)31-8-12-35-13-9-31)25-21(27-20)23(33)32-4-2-17(3-5-32)30-6-10-34-11-7-30/h14-15,17H,2-13H2,1H3,(H,25,26,27,28)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...


US Patent US10174035 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM320495
PNG
(US10174035, Compound 41 | [2-(1,3-Dimethyl-1H-pyra...)
Show SMILES Cc1nn(C)cc1-c1nc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CCC(CC1)N1CCOCC1
Show InChI InChI=1S/C24H33N9O3/c1-16-18(15-30(2)29-16)20-26-21-19(23(28-20)32-9-13-36-14-10-32)25-22(27-21)24(34)33-5-3-17(4-6-33)31-7-11-35-12-8-31/h15,17H,3-14H2,1-2H3,(H,25,26,27,28)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...


US Patent US10174035 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM320495
PNG
(US10174035, Compound 41 | [2-(1,3-Dimethyl-1H-pyra...)
Show SMILES Cc1nn(C)cc1-c1nc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CCC(CC1)N1CCOCC1
Show InChI InChI=1S/C24H33N9O3/c1-16-18(15-30(2)29-16)20-26-21-19(23(28-20)32-9-13-36-14-10-32)25-22(27-21)24(34)33-5-3-17(4-6-33)31-7-11-35-12-8-31/h15,17H,3-14H2,1-2H3,(H,25,26,27,28)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...


US Patent US10174035 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM320512
PNG
(US10174035, Compound 58 | [2-(1-Methyl-1H-pyrazol-...)
Show SMILES Cn1cc(cn1)-c1nc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CCC(CC1)N1CCOCC1
Show InChI InChI=1S/C23H31N9O3/c1-29-15-16(14-24-29)19-26-20-18(22(28-19)31-8-12-35-13-9-31)25-21(27-20)23(33)32-4-2-17(3-5-32)30-6-10-34-11-7-30/h14-15,17H,2-13H2,1H3,(H,25,26,27,28)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...


US Patent US10174035 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM320490
PNG
(N-(Cyclohexylmethyl)-2-(1-methyl-1H-pyrazol-4-yl)-...)
Show SMILES Cn1cc(cn1)-c1nc(N2CCOCC2)c2nc([nH]c2n1)C(=O)NCC1CCCCC1
Show InChI InChI=1S/C21H28N8O2/c1-28-13-15(12-23-28)17-25-18-16(20(27-17)29-7-9-31-10-8-29)24-19(26-18)21(30)22-11-14-5-3-2-4-6-14/h12-14H,2-11H2,1H3,(H,22,30)(H,24,25,26,27)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...


US Patent US10174035 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM320456
PNG
(US10174035, Compound 3 | [2-(1-Methyl-1H-pyrazol-4...)
Show SMILES Cn1cc(cn1)-c1nc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CCC2(COC2)CC1
Show InChI InChI=1S/C21H26N8O3/c1-27-11-14(10-22-27)16-24-17-15(19(26-16)28-6-8-31-9-7-28)23-18(25-17)20(30)29-4-2-21(3-5-29)12-32-13-21/h10-11H,2-9,12-13H2,1H3,(H,23,24,25,26)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...


US Patent US10174035 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM320569
PNG
(US10174035, Compound 112 | {4-[cis-2,6-Dimethylmor...)
Show SMILES C[C@H]1CN(C[C@@H](C)O1)C1CCN(CC1)C(=O)c1nc2c(N3CCOCC3)c(F)c(nc2n1C)-c1cn(C)nc1C
Show InChI InChI=1S/C28H39FN8O3/c1-17-14-37(15-18(2)40-17)20-6-8-36(9-7-20)28(38)27-31-24-25(35-10-12-39-13-11-35)22(29)23(30-26(24)34(27)5)21-16-33(4)32-19(21)3/h16-18,20H,6-15H2,1-5H3/t17-,18+
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...


US Patent US10174035 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM320456
PNG
(US10174035, Compound 3 | [2-(1-Methyl-1H-pyrazol-4...)
Show SMILES Cn1cc(cn1)-c1nc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CCC2(COC2)CC1
Show InChI InChI=1S/C21H26N8O3/c1-27-11-14(10-22-27)16-24-17-15(19(26-16)28-6-8-31-9-7-28)23-18(25-17)20(30)29-4-2-21(3-5-29)12-32-13-21/h10-11H,2-9,12-13H2,1H3,(H,23,24,25,26)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...


US Patent US10174035 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM320572
PNG
(5-(1-Methyl-1H-pyrazol-4-yl)-7-(morpholin-4-yl)-N-...)
Show SMILES Cn1cc(cn1)-c1cc(N2CCOCC2)c2nc([nH]c2n1)C(=O)NCCCN1CCOCC1
Show InChI InChI=1S/C22H30N8O3/c1-28-15-16(14-24-28)17-13-18(30-7-11-33-12-8-30)19-20(25-17)27-21(26-19)22(31)23-3-2-4-29-5-9-32-10-6-29/h13-15H,2-12H2,1H3,(H,23,31)(H,25,26,27)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...


US Patent US10174035 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM320468
PNG
(US10174035, Compound 14 | [4-(2-Hydroxypropan-2-yl...)
Show SMILES Cn1cc(cn1)-c1nc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CCC(CC1)C(C)(C)O
Show InChI InChI=1S/C22H30N8O3/c1-22(2,32)15-4-6-30(7-5-15)21(31)19-24-16-18(26-19)25-17(14-12-23-28(3)13-14)27-20(16)29-8-10-33-11-9-29/h12-13,15,32H,4-11H2,1-3H3,(H,24,25,26,27)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...


US Patent US10174035 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM320468
PNG
(US10174035, Compound 14 | [4-(2-Hydroxypropan-2-yl...)
Show SMILES Cn1cc(cn1)-c1nc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CCC(CC1)C(C)(C)O
Show InChI InChI=1S/C22H30N8O3/c1-22(2,32)15-4-6-30(7-5-15)21(31)19-24-16-18(26-19)25-17(14-12-23-28(3)13-14)27-20(16)29-8-10-33-11-9-29/h12-13,15,32H,4-11H2,1-3H3,(H,24,25,26,27)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...


US Patent US10174035 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM320518
PNG
(2-(1-Methyl-1H-pyrazol-4-yl)-N-{2-[1-methylpyrroli...)
Show SMILES CN1CCCC1CCNC(=O)c1nc2c(nc(nc2[nH]1)-c1cnn(C)c1)N1CCOCC1
Show InChI InChI=1S/C21H29N9O2/c1-28-7-3-4-15(28)5-6-22-21(31)19-24-16-18(26-19)25-17(14-12-23-29(2)13-14)27-20(16)30-8-10-32-11-9-30/h12-13,15H,3-11H2,1-2H3,(H,22,31)(H,24,25,26,27)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...


US Patent US10174035 (2019)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%