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Patent code US10179791

Compile Data Set for Download or QSAR
Found 122 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))
BDBM321299
PNG
(US10179791, Compound 51)
Show SMILES CCc1ccc(Cl)c(COc2ccc3c(OCC33CCN(CCC(O)=O)CC3)c2)c1
Show InChI InChI=1S/C24H28ClNO4/c1-2-17-3-6-21(25)18(13-17)15-29-19-4-5-20-22(14-19)30-16-24(20)8-11-26(12-9-24)10-7-23(27)28/h3-6,13-14H,2,7-12,15-16H2,1H3,(H,27,28)
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n/an/an/an/a<3.16E+3n/an/an/an/a



AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-K1-Human S1P1-c-AMP assay was performed at Euroscreenfast, Brussels (Euroscreen, Human S1P1 coupling Gi/0, (Edg1) receptor, catalog no: FAST-...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))
BDBM321300
PNG
(US10179791, Compound 59)
Show SMILES Cc1cc(Cl)c(COc2ccc3c(OCC33CCN(CCC(O)=O)CC3)c2)c(Cl)c1
Show InChI InChI=1S/C23H25Cl2NO4/c1-15-10-19(24)17(20(25)11-15)13-29-16-2-3-18-21(12-16)30-14-23(18)5-8-26(9-6-23)7-4-22(27)28/h2-3,10-12H,4-9,13-14H2,1H3,(H,27,28)
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n/an/an/an/a<3.16E+3n/an/an/an/a



AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-K1-Human S1P1-c-AMP assay was performed at Euroscreenfast, Brussels (Euroscreen, Human S1P1 coupling Gi/0, (Edg1) receptor, catalog no: FAST-...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 5


(Homo sapiens (human))
BDBM321302
PNG
(US10179791, Compound 74)
Show SMILES CC(C)c1cccc(Cl)c1COc1ccc2c(OCC22CCN(CCC(O)=O)CC2)c1
Show InChI InChI=1S/C25H30ClNO4/c1-17(2)19-4-3-5-22(26)20(19)15-30-18-6-7-21-23(14-18)31-16-25(21)9-12-27(13-10-25)11-8-24(28)29/h3-7,14,17H,8-13,15-16H2,1-2H3,(H,28,29)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-human-S1P5-Aeqorin assay was bought from Euroscreen, Brussels (Euroscreen, Technical dossier, Human Lysophospholid S1P5 (Edg8) receptor, DNA ...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 3


(Homo sapiens (human))
BDBM321305
PNG
(US10179791, Compound 79)
Show SMILES OC(=O)CCN1CCC2(COc3cc(OC4CCc5cc(Cl)cc(Cl)c45)ccc23)CC1
Show InChI InChI=1S/C24H25Cl2NO4/c25-16-11-15-1-4-20(23(15)19(26)12-16)31-17-2-3-18-21(13-17)30-14-24(18)6-9-27(10-7-24)8-5-22(28)29/h2-3,11-13,20H,1,4-10,14H2,(H,28,29)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-human-S1P3-Aeqorin assay (CHO/Gα16/AEQ/h-S1P3) was established at Solvay Pharmaceuticals. The plasmid DNA coding for the S1P3 receptor (...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 3


(Homo sapiens (human))
BDBM321306
PNG
(US10179791, Compound 100)
Show SMILES CC(CN1CCC2(COc3cc(OCc4c(Cl)cccc4Cl)ccc23)CC1)C(O)=O
Show InChI InChI=1S/C23H25Cl2NO4/c1-15(22(27)28)12-26-9-7-23(8-10-26)14-30-21-11-16(5-6-18(21)23)29-13-17-19(24)3-2-4-20(17)25/h2-6,11,15H,7-10,12-14H2,1H3,(H,27,28)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-human-S1P3-Aeqorin assay (CHO/Gα16/AEQ/h-S1P3) was established at Solvay Pharmaceuticals. The plasmid DNA coding for the S1P3 receptor (...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 3


(Homo sapiens (human))
BDBM321309
PNG
(US10179791, Compound 111)
Show SMILES CCc1cccc(Cl)c1COc1ccc2c(OCC22CCN(CC(O)=O)CC2)c1
Show InChI InChI=1S/C23H26ClNO4/c1-2-16-4-3-5-20(24)18(16)14-28-17-6-7-19-21(12-17)29-15-23(19)8-10-25(11-9-23)13-22(26)27/h3-7,12H,2,8-11,13-15H2,1H3,(H,26,27)
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n/an/an/an/a 2.00E+3n/an/an/an/a



AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-human-S1P3-Aeqorin assay (CHO/Gα16/AEQ/h-S1P3) was established at Solvay Pharmaceuticals. The plasmid DNA coding for the S1P3 receptor (...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 3


(Homo sapiens (human))
BDBM321310
PNG
(US10179791, Compound 121)
Show SMILES OC(=O)CCCN1CCC2(COc3cc(OCc4c(Cl)cccc4C4CC4)ccc23)CC1
Show InChI InChI=1S/C26H30ClNO4/c27-23-4-1-3-20(18-6-7-18)21(23)16-31-19-8-9-22-24(15-19)32-17-26(22)10-13-28(14-11-26)12-2-5-25(29)30/h1,3-4,8-9,15,18H,2,5-7,10-14,16-17H2,(H,29,30)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-human-S1P3-Aeqorin assay (CHO/Gα16/AEQ/h-S1P3) was established at Solvay Pharmaceuticals. The plasmid DNA coding for the S1P3 receptor (...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 5


(Homo sapiens (human))
BDBM321312
PNG
(US10179791, Compound 128)
Show SMILES OC(=O)CCCN1CCC2(COc3cc(OCc4c(Cl)cccc4Cl)ccc23)CC1
Show InChI InChI=1S/C23H25Cl2NO4/c24-19-3-1-4-20(25)17(19)14-29-16-6-7-18-21(13-16)30-15-23(18)8-11-26(12-9-23)10-2-5-22(27)28/h1,3-4,6-7,13H,2,5,8-12,14-15H2,(H,27,28)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-human-S1P5-Aeqorin assay was bought from Euroscreen, Brussels (Euroscreen, Technical dossier, Human Lysophospholid S1P5 (Edg8) receptor, DNA ...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 5


(Homo sapiens (human))
BDBM321313
PNG
(US10179791, Compound 129)
Show SMILES Cc1c2OCC3(CCN(CCC(O)=O)CC3)c2ccc1OCc1c(Cl)cccc1Cl
Show InChI InChI=1S/C23H25Cl2NO4/c1-15-20(29-13-16-18(24)3-2-4-19(16)25)6-5-17-22(15)30-14-23(17)8-11-26(12-9-23)10-7-21(27)28/h2-6H,7-14H2,1H3,(H,27,28)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-human-S1P5-Aeqorin assay was bought from Euroscreen, Brussels (Euroscreen, Technical dossier, Human Lysophospholid S1P5 (Edg8) receptor, DNA ...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 5


(Homo sapiens (human))
BDBM321314
PNG
(US10179791, Compound 132)
Show SMILES OC(=O)CCN1CCC2(COc3c2ccc(OCc2c(Cl)cc(Cl)cc2Cl)c3F)CC1
Show InChI InChI=1S/C22H21Cl3FNO4/c23-13-9-16(24)14(17(25)10-13)11-30-18-2-1-15-21(20(18)26)31-12-22(15)4-7-27(8-5-22)6-3-19(28)29/h1-2,9-10H,3-8,11-12H2,(H,28,29)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-human-S1P5-Aeqorin assay was bought from Euroscreen, Brussels (Euroscreen, Technical dossier, Human Lysophospholid S1P5 (Edg8) receptor, DNA ...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 3


(Homo sapiens (human))
BDBM321316
PNG
(US10179791, Compound 140)
Show SMILES CCc1cccc(Cl)c1CSc1ccc2c(OCC22CCN(CCC(O)=O)CC2)c1
Show InChI InChI=1S/C24H28ClNO3S/c1-2-17-4-3-5-21(25)19(17)15-30-18-6-7-20-22(14-18)29-16-24(20)9-12-26(13-10-24)11-8-23(27)28/h3-7,14H,2,8-13,15-16H2,1H3,(H,27,28)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-human-S1P3-Aeqorin assay (CHO/Gα16/AEQ/h-S1P3) was established at Solvay Pharmaceuticals. The plasmid DNA coding for the S1P3 receptor (...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 5


(Homo sapiens (human))
BDBM321317
PNG
(US10179791, Compound 141)
Show SMILES OC(=O)CCN1CCC2(COc3cc(SCc4c(Cl)cccc4C4CC4)ccc23)CC1
Show InChI InChI=1S/C25H28ClNO3S/c26-22-3-1-2-19(17-4-5-17)20(22)15-31-18-6-7-21-23(14-18)30-16-25(21)9-12-27(13-10-25)11-8-24(28)29/h1-3,6-7,14,17H,4-5,8-13,15-16H2,(H,28,29)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-human-S1P5-Aeqorin assay was bought from Euroscreen, Brussels (Euroscreen, Technical dossier, Human Lysophospholid S1P5 (Edg8) receptor, DNA ...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 5


(Homo sapiens (human))
BDBM321319
PNG
(US10179791, Compound 153)
Show SMILES CC(CN1CCC2(COc3cc(SCc4c(Cl)cccc4Cl)ccc23)CC1)C(O)=O
Show InChI InChI=1S/C23H25Cl2NO3S/c1-15(22(27)28)12-26-9-7-23(8-10-26)14-29-21-11-16(5-6-18(21)23)30-13-17-19(24)3-2-4-20(17)25/h2-6,11,15H,7-10,12-14H2,1H3,(H,27,28)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-human-S1P5-Aeqorin assay was bought from Euroscreen, Brussels (Euroscreen, Technical dossier, Human Lysophospholid S1P5 (Edg8) receptor, DNA ...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 3


(Homo sapiens (human))
BDBM321321
PNG
(US10179791, Compound 171)
Show SMILES OC(=O)CCN1CCC2(COc3cc(\C=C\c4ccccc4F)ccc23)CC1
Show InChI InChI=1S/C23H24FNO3/c24-20-4-2-1-3-18(20)7-5-17-6-8-19-21(15-17)28-16-23(19)10-13-25(14-11-23)12-9-22(26)27/h1-8,15H,9-14,16H2,(H,26,27)/b7-5+
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-human-S1P3-Aeqorin assay (CHO/Gα16/AEQ/h-S1P3) was established at Solvay Pharmaceuticals. The plasmid DNA coding for the S1P3 receptor (...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 3


(Homo sapiens (human))
BDBM321325
PNG
(US10179791, Compound 203)
Show SMILES OC(=O)CCN1CCC2(CC1)OCc1cc(OCc3c(Cl)cccc3Cl)ccc21
Show InChI InChI=1S/C22H23Cl2NO4/c23-19-2-1-3-20(24)17(19)14-28-16-4-5-18-15(12-16)13-29-22(18)7-10-25(11-8-22)9-6-21(26)27/h1-5,12H,6-11,13-14H2,(H,26,27)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-human-S1P3-Aeqorin assay (CHO/Gα16/AEQ/h-S1P3) was established at Solvay Pharmaceuticals. The plasmid DNA coding for the S1P3 receptor (...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 5


(Homo sapiens (human))
BDBM321327
PNG
(US10179791, Compound 252)
Show SMILES CC(C)c1cccc(F)c1COc1ccc2c(OCC22CCN(CCC(O)=O)CC2)c1
Show InChI InChI=1S/C25H30FNO4/c1-17(2)19-4-3-5-22(26)20(19)15-30-18-6-7-21-23(14-18)31-16-25(21)9-12-27(13-10-25)11-8-24(28)29/h3-7,14,17H,8-13,15-16H2,1-2H3,(H,28,29)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-human-S1P5-Aeqorin assay was bought from Euroscreen, Brussels (Euroscreen, Technical dossier, Human Lysophospholid S1P5 (Edg8) receptor, DNA ...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))
BDBM321327
PNG
(US10179791, Compound 252)
Show SMILES CC(C)c1cccc(F)c1COc1ccc2c(OCC22CCN(CCC(O)=O)CC2)c1
Show InChI InChI=1S/C25H30FNO4/c1-17(2)19-4-3-5-22(26)20(19)15-30-18-6-7-21-23(14-18)31-16-25(21)9-12-27(13-10-25)11-8-24(28)29/h3-7,14,17H,8-13,15-16H2,1-2H3,(H,28,29)
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n/an/an/an/a 5.01E+3n/an/an/an/a



AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-K1-human-S1P1-Aeqorin assay was bought from Euroscreen Fast, Brussels (Euroscreen, Technical dossier, Human S1P1 (Edg1) receptor, DNA clone a...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 3


(Homo sapiens (human))
BDBM321330
PNG
(US10179791, Compound 276)
Show SMILES CCCCCCCOc1ccc2c(OCC22CCN(CCC(O)=O)CC2)c1F
Show InChI InChI=1S/C22H32FNO4/c1-2-3-4-5-6-15-27-18-8-7-17-21(20(18)23)28-16-22(17)10-13-24(14-11-22)12-9-19(25)26/h7-8H,2-6,9-16H2,1H3,(H,25,26)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-human-S1P3-Aeqorin assay (CHO/Gα16/AEQ/h-S1P3) was established at Solvay Pharmaceuticals. The plasmid DNA coding for the S1P3 receptor (...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 5


(Homo sapiens (human))
BDBM321335
PNG
(US10179791, Compound 299)
Show SMILES OC(=O)CCN1CCC2(COc3cc(ccc23)S(=O)(=O)Cc2c(Cl)cccc2Cl)CC1
Show InChI InChI=1S/C22H23Cl2NO5S/c23-18-2-1-3-19(24)16(18)13-31(28,29)15-4-5-17-20(12-15)30-14-22(17)7-10-25(11-8-22)9-6-21(26)27/h1-5,12H,6-11,13-14H2,(H,26,27)
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n/an/an/an/a 1.00E+3n/an/an/an/a



AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-human-S1P5-Aeqorin assay was bought from Euroscreen, Brussels (Euroscreen, Technical dossier, Human Lysophospholid S1P5 (Edg8) receptor, DNA ...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 3


(Homo sapiens (human))
BDBM321338
PNG
(US10179791, Compound 321)
Show SMILES OC(=O)CCN1CCCC2(COc3cc(OCc4c(Cl)cccc4Cl)ccc23)C1
Show InChI InChI=1S/C22H23Cl2NO4/c23-18-3-1-4-19(24)16(18)12-28-15-5-6-17-20(11-15)29-14-22(17)8-2-9-25(13-22)10-7-21(26)27/h1,3-6,11H,2,7-10,12-14H2,(H,26,27)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-human-S1P3-Aeqorin assay (CHO/Gα16/AEQ/h-S1P3) was established at Solvay Pharmaceuticals. The plasmid DNA coding for the S1P3 receptor (...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 3


(Homo sapiens (human))
BDBM321339
PNG
(US10179791, Compound 326)
Show SMILES OC(=O)CCN1CCCC2(COc3cc(OCc4c(Cl)cccc4C(F)(F)F)ccc23)C1
Show InChI InChI=1S/C23H23ClF3NO4/c24-19-4-1-3-17(23(25,26)27)16(19)12-31-15-5-6-18-20(11-15)32-14-22(18)8-2-9-28(13-22)10-7-21(29)30/h1,3-6,11H,2,7-10,12-14H2,(H,29,30)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-human-S1P3-Aeqorin assay (CHO/Gα16/AEQ/h-S1P3) was established at Solvay Pharmaceuticals. The plasmid DNA coding for the S1P3 receptor (...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 3


(Homo sapiens (human))
BDBM321304
PNG
(US10179791, Compound 77)
Show SMILES OC(=O)CCN1CCC2(COc3cc(OCc4c(Cl)cccc4OC(F)(F)F)ccc23)CC1
Show InChI InChI=1S/C23H23ClF3NO5/c24-18-2-1-3-19(33-23(25,26)27)16(18)13-31-15-4-5-17-20(12-15)32-14-22(17)7-10-28(11-8-22)9-6-21(29)30/h1-5,12H,6-11,13-14H2,(H,29,30)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-human-S1P3-Aeqorin assay (CHO/Gα16/AEQ/h-S1P3) was established at Solvay Pharmaceuticals. The plasmid DNA coding for the S1P3 receptor (...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 5


(Homo sapiens (human))
BDBM321308
PNG
(US10179791, Compound 110)
Show SMILES OC(=O)CN1CCC2(COc3cc(OCc4c(Cl)cc(Cl)cc4Cl)ccc23)CC1
Show InChI InChI=1S/C21H20Cl3NO4/c22-13-7-17(23)15(18(24)8-13)11-28-14-1-2-16-19(9-14)29-12-21(16)3-5-25(6-4-21)10-20(26)27/h1-2,7-9H,3-6,10-12H2,(H,26,27)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-human-S1P5-Aeqorin assay was bought from Euroscreen, Brussels (Euroscreen, Technical dossier, Human Lysophospholid S1P5 (Edg8) receptor, DNA ...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))
BDBM321309
PNG
(US10179791, Compound 111)
Show SMILES CCc1cccc(Cl)c1COc1ccc2c(OCC22CCN(CC(O)=O)CC2)c1
Show InChI InChI=1S/C23H26ClNO4/c1-2-16-4-3-5-20(24)18(16)14-28-17-6-7-19-21(12-17)29-15-23(19)8-10-25(11-9-23)13-22(26)27/h3-7,12H,2,8-11,13-15H2,1H3,(H,26,27)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-K1-human-S1P1-Aeqorin assay was bought from Euroscreen Fast, Brussels (Euroscreen, Technical dossier, Human S1P1 (Edg1) receptor, DNA clone a...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 5


(Homo sapiens (human))
BDBM321311
PNG
(US10179791, Compound 127)
Show SMILES CC(C)c1cccc(Cl)c1COc1ccc2c(OCC22CCN(CCCC(O)=O)CC2)c1
Show InChI InChI=1S/C26H32ClNO4/c1-18(2)20-5-3-6-23(27)21(20)16-31-19-8-9-22-24(15-19)32-17-26(22)10-13-28(14-11-26)12-4-7-25(29)30/h3,5-6,8-9,15,18H,4,7,10-14,16-17H2,1-2H3,(H,29,30)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-human-S1P5-Aeqorin assay was bought from Euroscreen, Brussels (Euroscreen, Technical dossier, Human Lysophospholid S1P5 (Edg8) receptor, DNA ...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 3


(Homo sapiens (human))
BDBM321313
PNG
(US10179791, Compound 129)
Show SMILES Cc1c2OCC3(CCN(CCC(O)=O)CC3)c2ccc1OCc1c(Cl)cccc1Cl
Show InChI InChI=1S/C23H25Cl2NO4/c1-15-20(29-13-16-18(24)3-2-4-19(16)25)6-5-17-22(15)30-14-23(17)8-11-26(12-9-23)10-7-21(27)28/h2-6H,7-14H2,1H3,(H,27,28)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-human-S1P3-Aeqorin assay (CHO/Gα16/AEQ/h-S1P3) was established at Solvay Pharmaceuticals. The plasmid DNA coding for the S1P3 receptor (...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 3


(Homo sapiens (human))
BDBM321314
PNG
(US10179791, Compound 132)
Show SMILES OC(=O)CCN1CCC2(COc3c2ccc(OCc2c(Cl)cc(Cl)cc2Cl)c3F)CC1
Show InChI InChI=1S/C22H21Cl3FNO4/c23-13-9-16(24)14(17(25)10-13)11-30-18-2-1-15-21(20(18)26)31-12-22(15)4-7-27(8-5-22)6-3-19(28)29/h1-2,9-10H,3-8,11-12H2,(H,28,29)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-human-S1P3-Aeqorin assay (CHO/Gα16/AEQ/h-S1P3) was established at Solvay Pharmaceuticals. The plasmid DNA coding for the S1P3 receptor (...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 5


(Homo sapiens (human))
BDBM321316
PNG
(US10179791, Compound 140)
Show SMILES CCc1cccc(Cl)c1CSc1ccc2c(OCC22CCN(CCC(O)=O)CC2)c1
Show InChI InChI=1S/C24H28ClNO3S/c1-2-17-4-3-5-21(25)19(17)15-30-18-6-7-20-22(14-18)29-16-24(20)9-12-26(13-10-24)11-8-23(27)28/h3-7,14H,2,8-13,15-16H2,1H3,(H,27,28)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-human-S1P5-Aeqorin assay was bought from Euroscreen, Brussels (Euroscreen, Technical dossier, Human Lysophospholid S1P5 (Edg8) receptor, DNA ...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))
BDBM321322
PNG
(US10179791, Compound 176)
Show SMILES OC(=O)CN1CCC2(COc3cc(ccc23)C2CC2c2c(Cl)cccc2Cl)CC1
Show InChI InChI=1S/C23H23Cl2NO3/c24-18-2-1-3-19(25)22(18)16-11-15(16)14-4-5-17-20(10-14)29-13-23(17)6-8-26(9-7-23)12-21(27)28/h1-5,10,15-16H,6-9,11-13H2,(H,27,28)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-K1-human-S1P1-Aeqorin assay was bought from Euroscreen Fast, Brussels (Euroscreen, Technical dossier, Human S1P1 (Edg1) receptor, DNA clone a...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))
BDBM321323
PNG
(US10179791, Compound 178)
Show SMILES OC(=O)CCN1CCC2(COc3cc(ccc23)C2CC2c2c(Cl)cccc2Cl)CC1
Show InChI InChI=1S/C24H25Cl2NO3/c25-19-2-1-3-20(26)23(19)17-13-16(17)15-4-5-18-21(12-15)30-14-24(18)7-10-27(11-8-24)9-6-22(28)29/h1-5,12,16-17H,6-11,13-14H2,(H,28,29)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-K1-Human S1P1-c-AMP assay was performed at Euroscreenfast, Brussels (Euroscreen, Human S1P1 coupling Gi/0, (Edg1) receptor, catalog no: FAST-...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))
BDBM321324
PNG
(US10179791, Compound 182)
Show SMILES CCc1ccc(Cl)c(c1)C1CC1c1ccc2c(OCC22CCN(CCC(O)=O)CC2)c1
Show InChI InChI=1S/C26H30ClNO3/c1-2-17-3-6-23(27)21(13-17)20-15-19(20)18-4-5-22-24(14-18)31-16-26(22)8-11-28(12-9-26)10-7-25(29)30/h3-6,13-14,19-20H,2,7-12,15-16H2,1H3,(H,29,30)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-K1-Human S1P1-c-AMP assay was performed at Euroscreenfast, Brussels (Euroscreen, Human S1P1 coupling Gi/0, (Edg1) receptor, catalog no: FAST-...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 3


(Homo sapiens (human))
BDBM321328
PNG
(US10179791, Compound 253)
Show SMILES OC(=O)CCN1CCC2(COc3cc(OCc4c(F)cccc4C4CC4)ccc23)CC1
Show InChI InChI=1S/C25H28FNO4/c26-22-3-1-2-19(17-4-5-17)20(22)15-30-18-6-7-21-23(14-18)31-16-25(21)9-12-27(13-10-25)11-8-24(28)29/h1-3,6-7,14,17H,4-5,8-13,15-16H2,(H,28,29)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-human-S1P3-Aeqorin assay (CHO/Gα16/AEQ/h-S1P3) was established at Solvay Pharmaceuticals. The plasmid DNA coding for the S1P3 receptor (...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))
BDBM321330
PNG
(US10179791, Compound 276)
Show SMILES CCCCCCCOc1ccc2c(OCC22CCN(CCC(O)=O)CC2)c1F
Show InChI InChI=1S/C22H32FNO4/c1-2-3-4-5-6-15-27-18-8-7-17-21(20(18)23)28-16-22(17)10-13-24(14-11-22)12-9-19(25)26/h7-8H,2-6,9-16H2,1H3,(H,25,26)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-K1-human-S1P1-Aeqorin assay was bought from Euroscreen Fast, Brussels (Euroscreen, Technical dossier, Human S1P1 (Edg1) receptor, DNA clone a...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 5


(Homo sapiens (human))
BDBM321331
PNG
(US10179791, Compound 277)
Show SMILES CCCCCCCCOc1ccc2c(OCC22CCN(CCC(O)=O)CC2)c1F
Show InChI InChI=1S/C23H34FNO4/c1-2-3-4-5-6-7-16-28-19-9-8-18-22(21(19)24)29-17-23(18)11-14-25(15-12-23)13-10-20(26)27/h8-9H,2-7,10-17H2,1H3,(H,26,27)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-human-S1P5-Aeqorin assay was bought from Euroscreen, Brussels (Euroscreen, Technical dossier, Human Lysophospholid S1P5 (Edg8) receptor, DNA ...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))
BDBM321331
PNG
(US10179791, Compound 277)
Show SMILES CCCCCCCCOc1ccc2c(OCC22CCN(CCC(O)=O)CC2)c1F
Show InChI InChI=1S/C23H34FNO4/c1-2-3-4-5-6-7-16-28-19-9-8-18-22(21(19)24)29-17-23(18)11-14-25(15-12-23)13-10-20(26)27/h8-9H,2-7,10-17H2,1H3,(H,26,27)
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n/an/an/an/a 79.4n/an/an/an/a



AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-K1-human-S1P1-Aeqorin assay was bought from Euroscreen Fast, Brussels (Euroscreen, Technical dossier, Human S1P1 (Edg1) receptor, DNA clone a...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 3


(Homo sapiens (human))
BDBM321333
PNG
(US10179791, Compound 296)
Show SMILES CCc1cccc(Cl)c1CSc1ccc2c(OCC22CCN(CCC(O)=O)CC2)c1F
Show InChI InChI=1S/C24H27ClFNO3S/c1-2-16-4-3-5-19(25)17(16)14-31-20-7-6-18-23(22(20)26)30-15-24(18)9-12-27(13-10-24)11-8-21(28)29/h3-7H,2,8-15H2,1H3,(H,28,29)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-human-S1P3-Aeqorin assay (CHO/Gα16/AEQ/h-S1P3) was established at Solvay Pharmaceuticals. The plasmid DNA coding for the S1P3 receptor (...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))
BDBM321335
PNG
(US10179791, Compound 299)
Show SMILES OC(=O)CCN1CCC2(COc3cc(ccc23)S(=O)(=O)Cc2c(Cl)cccc2Cl)CC1
Show InChI InChI=1S/C22H23Cl2NO5S/c23-18-2-1-3-19(24)16(18)13-31(28,29)15-4-5-17-20(12-15)30-14-22(17)7-10-25(11-8-22)9-6-21(26)27/h1-5,12H,6-11,13-14H2,(H,26,27)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-K1-human-S1P1-Aeqorin assay was bought from Euroscreen Fast, Brussels (Euroscreen, Technical dossier, Human S1P1 (Edg1) receptor, DNA clone a...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 5


(Homo sapiens (human))
BDBM321339
PNG
(US10179791, Compound 326)
Show SMILES OC(=O)CCN1CCCC2(COc3cc(OCc4c(Cl)cccc4C(F)(F)F)ccc23)C1
Show InChI InChI=1S/C23H23ClF3NO4/c24-19-4-1-3-17(23(25,26)27)16(19)12-31-15-5-6-18-20(11-15)32-14-22(18)8-2-9-28(13-22)10-7-21(29)30/h1,3-6,11H,2,7-10,12-14H2,(H,29,30)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-human-S1P5-Aeqorin assay was bought from Euroscreen, Brussels (Euroscreen, Technical dossier, Human Lysophospholid S1P5 (Edg8) receptor, DNA ...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))
BDBM321339
PNG
(US10179791, Compound 326)
Show SMILES OC(=O)CCN1CCCC2(COc3cc(OCc4c(Cl)cccc4C(F)(F)F)ccc23)C1
Show InChI InChI=1S/C23H23ClF3NO4/c24-19-4-1-3-17(23(25,26)27)16(19)12-31-15-5-6-18-20(11-15)32-14-22(18)8-2-9-28(13-22)10-7-21(29)30/h1,3-6,11H,2,7-10,12-14H2,(H,29,30)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-K1-human-S1P1-Aeqorin assay was bought from Euroscreen Fast, Brussels (Euroscreen, Technical dossier, Human S1P1 (Edg1) receptor, DNA clone a...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))
BDBM321301
PNG
(US10179791, Compound 68)
Show SMILES CCc1ccc(Cl)c(COc2ccc3c(OCC33CCN(CCC(O)=O)CC3)c2)c1Cl
Show InChI InChI=1S/C24H27Cl2NO4/c1-2-16-3-6-20(25)18(23(16)26)14-30-17-4-5-19-21(13-17)31-15-24(19)8-11-27(12-9-24)10-7-22(28)29/h3-6,13H,2,7-12,14-15H2,1H3,(H,28,29)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-K1-Human S1P1-c-AMP assay was performed at Euroscreenfast, Brussels (Euroscreen, Human S1P1 coupling Gi/0, (Edg1) receptor, catalog no: FAST-...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))
BDBM321306
PNG
(US10179791, Compound 100)
Show SMILES CC(CN1CCC2(COc3cc(OCc4c(Cl)cccc4Cl)ccc23)CC1)C(O)=O
Show InChI InChI=1S/C23H25Cl2NO4/c1-15(22(27)28)12-26-9-7-23(8-10-26)14-30-21-11-16(5-6-18(21)23)29-13-17-19(24)3-2-4-20(17)25/h2-6,11,15H,7-10,12-14H2,1H3,(H,27,28)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-K1-Human S1P1-c-AMP assay was performed at Euroscreenfast, Brussels (Euroscreen, Human S1P1 coupling Gi/0, (Edg1) receptor, catalog no: FAST-...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))
BDBM321308
PNG
(US10179791, Compound 110)
Show SMILES OC(=O)CN1CCC2(COc3cc(OCc4c(Cl)cc(Cl)cc4Cl)ccc23)CC1
Show InChI InChI=1S/C21H20Cl3NO4/c22-13-7-17(23)15(18(24)8-13)11-28-14-1-2-16-19(9-14)29-12-21(16)3-5-25(6-4-21)10-20(26)27/h1-2,7-9H,3-6,10-12H2,(H,26,27)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-K1-human-S1P1-Aeqorin assay was bought from Euroscreen Fast, Brussels (Euroscreen, Technical dossier, Human S1P1 (Edg1) receptor, DNA clone a...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 3


(Homo sapiens (human))
BDBM321312
PNG
(US10179791, Compound 128)
Show SMILES OC(=O)CCCN1CCC2(COc3cc(OCc4c(Cl)cccc4Cl)ccc23)CC1
Show InChI InChI=1S/C23H25Cl2NO4/c24-19-3-1-4-20(25)17(19)14-29-16-6-7-18-21(13-16)30-15-23(18)8-11-26(12-9-23)10-2-5-22(27)28/h1,3-4,6-7,13H,2,5,8-12,14-15H2,(H,27,28)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-human-S1P3-Aeqorin assay (CHO/Gα16/AEQ/h-S1P3) was established at Solvay Pharmaceuticals. The plasmid DNA coding for the S1P3 receptor (...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))
BDBM321315
PNG
(US10179791, Compound 136)
Show SMILES CCc1cccc(Cl)c1COc1ccc2c(OCC22CCN(CCC(O)=O)CC2)c1F
Show InChI InChI=1S/C24H27ClFNO4/c1-2-16-4-3-5-19(25)17(16)14-30-20-7-6-18-23(22(20)26)31-15-24(18)9-12-27(13-10-24)11-8-21(28)29/h3-7H,2,8-15H2,1H3,(H,28,29)
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n/an/an/an/a 1.26E+3n/an/an/an/a



AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-K1-human-S1P1-Aeqorin assay was bought from Euroscreen Fast, Brussels (Euroscreen, Technical dossier, Human S1P1 (Edg1) receptor, DNA clone a...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))
BDBM321319
PNG
(US10179791, Compound 153)
Show SMILES CC(CN1CCC2(COc3cc(SCc4c(Cl)cccc4Cl)ccc23)CC1)C(O)=O
Show InChI InChI=1S/C23H25Cl2NO3S/c1-15(22(27)28)12-26-9-7-23(8-10-26)14-29-21-11-16(5-6-18(21)23)30-13-17-19(24)3-2-4-20(17)25/h2-6,11,15H,7-10,12-14H2,1H3,(H,27,28)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-K1-human-S1P1-Aeqorin assay was bought from Euroscreen Fast, Brussels (Euroscreen, Technical dossier, Human S1P1 (Edg1) receptor, DNA clone a...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 3


(Homo sapiens (human))
BDBM321324
PNG
(US10179791, Compound 182)
Show SMILES CCc1ccc(Cl)c(c1)C1CC1c1ccc2c(OCC22CCN(CCC(O)=O)CC2)c1
Show InChI InChI=1S/C26H30ClNO3/c1-2-17-3-6-23(27)21(13-17)20-15-19(20)18-4-5-22-24(14-18)31-16-26(22)8-11-28(12-9-26)10-7-25(29)30/h3-6,13-14,19-20H,2,7-12,15-16H2,1H3,(H,29,30)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-human-S1P3-Aeqorin assay (CHO/Gα16/AEQ/h-S1P3) was established at Solvay Pharmaceuticals. The plasmid DNA coding for the S1P3 receptor (...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))
BDBM321325
PNG
(US10179791, Compound 203)
Show SMILES OC(=O)CCN1CCC2(CC1)OCc1cc(OCc3c(Cl)cccc3Cl)ccc21
Show InChI InChI=1S/C22H23Cl2NO4/c23-19-2-1-3-20(24)17(19)14-28-16-4-5-18-15(12-16)13-29-22(18)7-10-25(11-8-22)9-6-21(26)27/h1-5,12H,6-11,13-14H2,(H,26,27)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-K1-human-S1P1-Aeqorin assay was bought from Euroscreen Fast, Brussels (Euroscreen, Technical dossier, Human S1P1 (Edg1) receptor, DNA clone a...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 5


(Homo sapiens (human))
BDBM321330
PNG
(US10179791, Compound 276)
Show SMILES CCCCCCCOc1ccc2c(OCC22CCN(CCC(O)=O)CC2)c1F
Show InChI InChI=1S/C22H32FNO4/c1-2-3-4-5-6-15-27-18-8-7-17-21(20(18)23)28-16-22(17)10-13-24(14-11-22)12-9-19(25)26/h7-8H,2-6,9-16H2,1H3,(H,25,26)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-human-S1P5-Aeqorin assay was bought from Euroscreen, Brussels (Euroscreen, Technical dossier, Human Lysophospholid S1P5 (Edg8) receptor, DNA ...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 5


(Homo sapiens (human))
BDBM321336
PNG
(US10179791, Compound 303)
Show SMILES OC(=O)CCN1CCC2(COc3cc(ccc23)C#Cc2ccccc2)CC1
Show InChI InChI=1S/C23H23NO3/c25-22(26)10-13-24-14-11-23(12-15-24)17-27-21-16-19(8-9-20(21)23)7-6-18-4-2-1-3-5-18/h1-5,8-9,16H,10-15,17H2,(H,25,26)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-human-S1P5-Aeqorin assay was bought from Euroscreen, Brussels (Euroscreen, Technical dossier, Human Lysophospholid S1P5 (Edg8) receptor, DNA ...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 5


(Homo sapiens (human))
BDBM321298
PNG
(US10179791, Compound 38)
Show SMILES OC(=O)CCN1CCC2(COc3cc(OCc4c(F)cccc4Cl)ccc23)CC1
Show InChI InChI=1S/C22H23ClFNO4/c23-18-2-1-3-19(24)16(18)13-28-15-4-5-17-20(12-15)29-14-22(17)7-10-25(11-8-22)9-6-21(26)27/h1-5,12H,6-11,13-14H2,(H,26,27)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-human-S1P5-Aeqorin assay was bought from Euroscreen, Brussels (Euroscreen, Technical dossier, Human Lysophospholid S1P5 (Edg8) receptor, DNA ...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 3


(Homo sapiens (human))
BDBM321298
PNG
(US10179791, Compound 38)
Show SMILES OC(=O)CCN1CCC2(COc3cc(OCc4c(F)cccc4Cl)ccc23)CC1
Show InChI InChI=1S/C22H23ClFNO4/c23-18-2-1-3-19(24)16(18)13-28-15-4-5-17-20(12-15)29-14-22(17)7-10-25(11-8-22)9-6-21(26)27/h1-5,12H,6-11,13-14H2,(H,26,27)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-human-S1P3-Aeqorin assay (CHO/Gα16/AEQ/h-S1P3) was established at Solvay Pharmaceuticals. The plasmid DNA coding for the S1P3 receptor (...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 5


(Homo sapiens (human))
BDBM321305
PNG
(US10179791, Compound 79)
Show SMILES OC(=O)CCN1CCC2(COc3cc(OC4CCc5cc(Cl)cc(Cl)c45)ccc23)CC1
Show InChI InChI=1S/C24H25Cl2NO4/c25-16-11-15-1-4-20(23(15)19(26)12-16)31-17-2-3-18-21(13-17)30-14-24(18)6-9-27(10-7-24)8-5-22(28)29/h2-3,11-13,20H,1,4-10,14H2,(H,28,29)
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n/an/an/an/a 63.1n/an/an/an/a



AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-human-S1P5-Aeqorin assay was bought from Euroscreen, Brussels (Euroscreen, Technical dossier, Human Lysophospholid S1P5 (Edg8) receptor, DNA ...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))
BDBM321305
PNG
(US10179791, Compound 79)
Show SMILES OC(=O)CCN1CCC2(COc3cc(OC4CCc5cc(Cl)cc(Cl)c45)ccc23)CC1
Show InChI InChI=1S/C24H25Cl2NO4/c25-16-11-15-1-4-20(23(15)19(26)12-16)31-17-2-3-18-21(13-17)30-14-24(18)6-9-27(10-7-24)8-5-22(28)29/h2-3,11-13,20H,1,4-10,14H2,(H,28,29)
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n/an/an/an/a 2.00E+3n/an/an/an/a



AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-K1-Human S1P1-c-AMP assay was performed at Euroscreenfast, Brussels (Euroscreen, Human S1P1 coupling Gi/0, (Edg1) receptor, catalog no: FAST-...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))
BDBM321316
PNG
(US10179791, Compound 140)
Show SMILES CCc1cccc(Cl)c1CSc1ccc2c(OCC22CCN(CCC(O)=O)CC2)c1
Show InChI InChI=1S/C24H28ClNO3S/c1-2-17-4-3-5-21(25)19(17)15-30-18-6-7-20-22(14-18)29-16-24(20)9-12-26(13-10-24)11-8-23(27)28/h3-7,14H,2,8-13,15-16H2,1H3,(H,27,28)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-K1-human-S1P1-Aeqorin assay was bought from Euroscreen Fast, Brussels (Euroscreen, Technical dossier, Human S1P1 (Edg1) receptor, DNA clone a...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))
BDBM321317
PNG
(US10179791, Compound 141)
Show SMILES OC(=O)CCN1CCC2(COc3cc(SCc4c(Cl)cccc4C4CC4)ccc23)CC1
Show InChI InChI=1S/C25H28ClNO3S/c26-22-3-1-2-19(17-4-5-17)20(22)15-31-18-6-7-21-23(14-18)30-16-25(21)9-12-27(13-10-25)11-8-24(28)29/h1-3,6-7,14,17H,4-5,8-13,15-16H2,(H,28,29)
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n/an/an/an/a 316n/an/an/an/a



AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-K1-human-S1P1-Aeqorin assay was bought from Euroscreen Fast, Brussels (Euroscreen, Technical dossier, Human S1P1 (Edg1) receptor, DNA clone a...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 5


(Homo sapiens (human))
BDBM321318
PNG
(US10179791, Compound 143)
Show SMILES OC(=O)CCN1CCC2(COc3cc(SCc4c(Cl)cc(Cl)cc4Cl)ccc23)CC1
Show InChI InChI=1S/C22H22Cl3NO3S/c23-14-9-18(24)16(19(25)10-14)12-30-15-1-2-17-20(11-15)29-13-22(17)4-7-26(8-5-22)6-3-21(27)28/h1-2,9-11H,3-8,12-13H2,(H,27,28)
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n/an/an/an/a 31.6n/an/an/an/a



AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-human-S1P5-Aeqorin assay was bought from Euroscreen, Brussels (Euroscreen, Technical dossier, Human Lysophospholid S1P5 (Edg8) receptor, DNA ...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))
BDBM321321
PNG
(US10179791, Compound 171)
Show SMILES OC(=O)CCN1CCC2(COc3cc(\C=C\c4ccccc4F)ccc23)CC1
Show InChI InChI=1S/C23H24FNO3/c24-20-4-2-1-3-18(20)7-5-17-6-8-19-21(15-17)28-16-23(19)10-13-25(14-11-23)12-9-22(26)27/h1-8,15H,9-14,16H2,(H,26,27)/b7-5+
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-K1-Human S1P1-c-AMP assay was performed at Euroscreenfast, Brussels (Euroscreen, Human S1P1 coupling Gi/0, (Edg1) receptor, catalog no: FAST-...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 3


(Homo sapiens (human))
BDBM321323
PNG
(US10179791, Compound 178)
Show SMILES OC(=O)CCN1CCC2(COc3cc(ccc23)C2CC2c2c(Cl)cccc2Cl)CC1
Show InChI InChI=1S/C24H25Cl2NO3/c25-19-2-1-3-20(26)23(19)17-13-16(17)15-4-5-18-21(12-15)30-14-24(18)7-10-27(11-8-24)9-6-22(28)29/h1-5,12,16-17H,6-11,13-14H2,(H,28,29)
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n/an/an/an/a 3.16E+3n/an/an/an/a



AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-human-S1P3-Aeqorin assay (CHO/Gα16/AEQ/h-S1P3) was established at Solvay Pharmaceuticals. The plasmid DNA coding for the S1P3 receptor (...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 5


(Homo sapiens (human))
BDBM321326
PNG
(US10179791, Compound 248)
Show SMILES OC(=O)CCN1CCC2(COc3cc(Oc4c(Cl)cccc4Cl)ccc23)CC1
Show InChI InChI=1S/C21H21Cl2NO4/c22-16-2-1-3-17(23)20(16)28-14-4-5-15-18(12-14)27-13-21(15)7-10-24(11-8-21)9-6-19(25)26/h1-5,12H,6-11,13H2,(H,25,26)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-human-S1P5-Aeqorin assay was bought from Euroscreen, Brussels (Euroscreen, Technical dossier, Human Lysophospholid S1P5 (Edg8) receptor, DNA ...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 3


(Homo sapiens (human))
BDBM321329
PNG
(US10179791, Compound 258)
Show SMILES CCc1cccc(CC)c1COc1ccc2c(OCC22CCN(CCC(O)=O)CC2)c1
Show InChI InChI=1S/C26H33NO4/c1-3-19-6-5-7-20(4-2)22(19)17-30-21-8-9-23-24(16-21)31-18-26(23)11-14-27(15-12-26)13-10-25(28)29/h5-9,16H,3-4,10-15,17-18H2,1-2H3,(H,28,29)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-human-S1P3-Aeqorin assay (CHO/Gα16/AEQ/h-S1P3) was established at Solvay Pharmaceuticals. The plasmid DNA coding for the S1P3 receptor (...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 5


(Homo sapiens (human))
BDBM321337
PNG
(US10179791, Compound 317)
Show SMILES OC(=O)CCN1CCCC2(COc3cc(OCc4c(Cl)cccc4C4CC4)ccc23)C1
Show InChI InChI=1S/C25H28ClNO4/c26-22-4-1-3-19(17-5-6-17)20(22)14-30-18-7-8-21-23(13-18)31-16-25(21)10-2-11-27(15-25)12-9-24(28)29/h1,3-4,7-8,13,17H,2,5-6,9-12,14-16H2,(H,28,29)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-human-S1P5-Aeqorin assay was bought from Euroscreen, Brussels (Euroscreen, Technical dossier, Human Lysophospholid S1P5 (Edg8) receptor, DNA ...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 3


(Homo sapiens (human))
BDBM321300
PNG
(US10179791, Compound 59)
Show SMILES Cc1cc(Cl)c(COc2ccc3c(OCC33CCN(CCC(O)=O)CC3)c2)c(Cl)c1
Show InChI InChI=1S/C23H25Cl2NO4/c1-15-10-19(24)17(20(25)11-15)13-29-16-2-3-18-21(12-16)30-14-23(18)5-8-26(9-6-23)7-4-22(27)28/h2-3,10-12H,4-9,13-14H2,1H3,(H,27,28)
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n/an/an/an/a<1.00E+4n/an/an/an/a



AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-human-S1P3-Aeqorin assay (CHO/Gα16/AEQ/h-S1P3) was established at Solvay Pharmaceuticals. The plasmid DNA coding for the S1P3 receptor (...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 3


(Homo sapiens (human))
BDBM321301
PNG
(US10179791, Compound 68)
Show SMILES CCc1ccc(Cl)c(COc2ccc3c(OCC33CCN(CCC(O)=O)CC3)c2)c1Cl
Show InChI InChI=1S/C24H27Cl2NO4/c1-2-16-3-6-20(25)18(23(16)26)14-30-17-4-5-19-21(13-17)31-15-24(19)8-11-27(12-9-24)10-7-22(28)29/h3-6,13H,2,7-12,14-15H2,1H3,(H,28,29)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-human-S1P3-Aeqorin assay (CHO/Gα16/AEQ/h-S1P3) was established at Solvay Pharmaceuticals. The plasmid DNA coding for the S1P3 receptor (...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))
BDBM321302
PNG
(US10179791, Compound 74)
Show SMILES CC(C)c1cccc(Cl)c1COc1ccc2c(OCC22CCN(CCC(O)=O)CC2)c1
Show InChI InChI=1S/C25H30ClNO4/c1-17(2)19-4-3-5-22(26)20(19)15-30-18-6-7-21-23(14-18)31-16-25(21)9-12-27(13-10-25)11-8-24(28)29/h3-7,14,17H,8-13,15-16H2,1-2H3,(H,28,29)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-K1-Human S1P1-c-AMP assay was performed at Euroscreenfast, Brussels (Euroscreen, Human S1P1 coupling Gi/0, (Edg1) receptor, catalog no: FAST-...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))
BDBM321307
PNG
(US10179791, Compound 102)
Show SMILES CC(CN1CCC2(COc3cc(OCc4c(Cl)cc(Cl)cc4Cl)ccc23)CC1)C(O)=O
Show InChI InChI=1S/C23H24Cl3NO4/c1-14(22(28)29)11-27-6-4-23(5-7-27)13-31-21-10-16(2-3-18(21)23)30-12-17-19(25)8-15(24)9-20(17)26/h2-3,8-10,14H,4-7,11-13H2,1H3,(H,28,29)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-K1-human-S1P1-Aeqorin assay was bought from Euroscreen Fast, Brussels (Euroscreen, Technical dossier, Human S1P1 (Edg1) receptor, DNA clone a...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 3


(Homo sapiens (human))
BDBM321308
PNG
(US10179791, Compound 110)
Show SMILES OC(=O)CN1CCC2(COc3cc(OCc4c(Cl)cc(Cl)cc4Cl)ccc23)CC1
Show InChI InChI=1S/C21H20Cl3NO4/c22-13-7-17(23)15(18(24)8-13)11-28-14-1-2-16-19(9-14)29-12-21(16)3-5-25(6-4-21)10-20(26)27/h1-2,7-9H,3-6,10-12H2,(H,26,27)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-human-S1P3-Aeqorin assay (CHO/Gα16/AEQ/h-S1P3) was established at Solvay Pharmaceuticals. The plasmid DNA coding for the S1P3 receptor (...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 5


(Homo sapiens (human))
BDBM321309
PNG
(US10179791, Compound 111)
Show SMILES CCc1cccc(Cl)c1COc1ccc2c(OCC22CCN(CC(O)=O)CC2)c1
Show InChI InChI=1S/C23H26ClNO4/c1-2-16-4-3-5-20(24)18(16)14-28-17-6-7-19-21(12-17)29-15-23(19)8-10-25(11-9-23)13-22(26)27/h3-7,12H,2,8-11,13-15H2,1H3,(H,26,27)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-human-S1P5-Aeqorin assay was bought from Euroscreen, Brussels (Euroscreen, Technical dossier, Human Lysophospholid S1P5 (Edg8) receptor, DNA ...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 3


(Homo sapiens (human))
BDBM321311
PNG
(US10179791, Compound 127)
Show SMILES CC(C)c1cccc(Cl)c1COc1ccc2c(OCC22CCN(CCCC(O)=O)CC2)c1
Show InChI InChI=1S/C26H32ClNO4/c1-18(2)20-5-3-6-23(27)21(20)16-31-19-8-9-22-24(15-19)32-17-26(22)10-13-28(14-11-26)12-4-7-25(29)30/h3,5-6,8-9,15,18H,4,7,10-14,16-17H2,1-2H3,(H,29,30)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-human-S1P3-Aeqorin assay (CHO/Gα16/AEQ/h-S1P3) was established at Solvay Pharmaceuticals. The plasmid DNA coding for the S1P3 receptor (...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 3


(Homo sapiens (human))
BDBM321315
PNG
(US10179791, Compound 136)
Show SMILES CCc1cccc(Cl)c1COc1ccc2c(OCC22CCN(CCC(O)=O)CC2)c1F
Show InChI InChI=1S/C24H27ClFNO4/c1-2-16-4-3-5-19(25)17(16)14-30-20-7-6-18-23(22(20)26)31-15-24(18)9-12-27(13-10-24)11-8-21(28)29/h3-7H,2,8-15H2,1H3,(H,28,29)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-human-S1P3-Aeqorin assay (CHO/Gα16/AEQ/h-S1P3) was established at Solvay Pharmaceuticals. The plasmid DNA coding for the S1P3 receptor (...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 3


(Homo sapiens (human))
BDBM321317
PNG
(US10179791, Compound 141)
Show SMILES OC(=O)CCN1CCC2(COc3cc(SCc4c(Cl)cccc4C4CC4)ccc23)CC1
Show InChI InChI=1S/C25H28ClNO3S/c26-22-3-1-2-19(17-4-5-17)20(22)15-31-18-6-7-21-23(14-18)30-16-25(21)9-12-27(13-10-25)11-8-24(28)29/h1-3,6-7,14,17H,4-5,8-13,15-16H2,(H,28,29)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-human-S1P3-Aeqorin assay (CHO/Gα16/AEQ/h-S1P3) was established at Solvay Pharmaceuticals. The plasmid DNA coding for the S1P3 receptor (...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 5


(Homo sapiens (human))
BDBM321323
PNG
(US10179791, Compound 178)
Show SMILES OC(=O)CCN1CCC2(COc3cc(ccc23)C2CC2c2c(Cl)cccc2Cl)CC1
Show InChI InChI=1S/C24H25Cl2NO3/c25-19-2-1-3-20(26)23(19)17-13-16(17)15-4-5-18-21(12-15)30-14-24(18)7-10-27(11-8-24)9-6-22(28)29/h1-5,12,16-17H,6-11,13-14H2,(H,28,29)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-human-S1P5-Aeqorin assay was bought from Euroscreen, Brussels (Euroscreen, Technical dossier, Human Lysophospholid S1P5 (Edg8) receptor, DNA ...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 5


(Homo sapiens (human))
BDBM321324
PNG
(US10179791, Compound 182)
Show SMILES CCc1ccc(Cl)c(c1)C1CC1c1ccc2c(OCC22CCN(CCC(O)=O)CC2)c1
Show InChI InChI=1S/C26H30ClNO3/c1-2-17-3-6-23(27)21(13-17)20-15-19(20)18-4-5-22-24(14-18)31-16-26(22)8-11-28(12-9-26)10-7-25(29)30/h3-6,13-14,19-20H,2,7-12,15-16H2,1H3,(H,29,30)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-human-S1P5-Aeqorin assay was bought from Euroscreen, Brussels (Euroscreen, Technical dossier, Human Lysophospholid S1P5 (Edg8) receptor, DNA ...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 5


(Homo sapiens (human))
BDBM321325
PNG
(US10179791, Compound 203)
Show SMILES OC(=O)CCN1CCC2(CC1)OCc1cc(OCc3c(Cl)cccc3Cl)ccc21
Show InChI InChI=1S/C22H23Cl2NO4/c23-19-2-1-3-20(24)17(19)14-28-16-4-5-18-15(12-16)13-29-22(18)7-10-25(11-8-22)9-6-21(26)27/h1-5,12H,6-11,13-14H2,(H,26,27)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-human-S1P5-Aeqorin assay was bought from Euroscreen, Brussels (Euroscreen, Technical dossier, Human Lysophospholid S1P5 (Edg8) receptor, DNA ...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 3


(Homo sapiens (human))
BDBM321326
PNG
(US10179791, Compound 248)
Show SMILES OC(=O)CCN1CCC2(COc3cc(Oc4c(Cl)cccc4Cl)ccc23)CC1
Show InChI InChI=1S/C21H21Cl2NO4/c22-16-2-1-3-17(23)20(16)28-14-4-5-15-18(12-14)27-13-21(15)7-10-24(11-8-21)9-6-19(25)26/h1-5,12H,6-11,13H2,(H,25,26)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-human-S1P3-Aeqorin assay (CHO/Gα16/AEQ/h-S1P3) was established at Solvay Pharmaceuticals. The plasmid DNA coding for the S1P3 receptor (...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 3


(Homo sapiens (human))
BDBM321332
PNG
(US10179791, Compound 289)
Show SMILES OC(=O)CCN1CCC2(COc3cc(OCc4c(Cl)cccc4Cl)c(F)cc23)CC1
Show InChI InChI=1S/C22H22Cl2FNO4/c23-16-2-1-3-17(24)14(16)12-29-20-11-19-15(10-18(20)25)22(13-30-19)5-8-26(9-6-22)7-4-21(27)28/h1-3,10-11H,4-9,12-13H2,(H,27,28)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-human-S1P3-Aeqorin assay (CHO/Gα16/AEQ/h-S1P3) was established at Solvay Pharmaceuticals. The plasmid DNA coding for the S1P3 receptor (...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))
BDBM321337
PNG
(US10179791, Compound 317)
Show SMILES OC(=O)CCN1CCCC2(COc3cc(OCc4c(Cl)cccc4C4CC4)ccc23)C1
Show InChI InChI=1S/C25H28ClNO4/c26-22-4-1-3-19(17-5-6-17)20(22)14-30-18-7-8-21-23(13-18)31-16-25(21)10-2-11-27(15-25)12-9-24(28)29/h1,3-4,7-8,13,17H,2,5-6,9-12,14-16H2,(H,28,29)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-K1-human-S1P1-Aeqorin assay was bought from Euroscreen Fast, Brussels (Euroscreen, Technical dossier, Human S1P1 (Edg1) receptor, DNA clone a...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 3


(Homo sapiens (human))
BDBM321337
PNG
(US10179791, Compound 317)
Show SMILES OC(=O)CCN1CCCC2(COc3cc(OCc4c(Cl)cccc4C4CC4)ccc23)C1
Show InChI InChI=1S/C25H28ClNO4/c26-22-4-1-3-19(17-5-6-17)20(22)14-30-18-7-8-21-23(13-18)31-16-25(21)10-2-11-27(15-25)12-9-24(28)29/h1,3-4,7-8,13,17H,2,5-6,9-12,14-16H2,(H,28,29)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-human-S1P3-Aeqorin assay (CHO/Gα16/AEQ/h-S1P3) was established at Solvay Pharmaceuticals. The plasmid DNA coding for the S1P3 receptor (...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))
BDBM321338
PNG
(US10179791, Compound 321)
Show SMILES OC(=O)CCN1CCCC2(COc3cc(OCc4c(Cl)cccc4Cl)ccc23)C1
Show InChI InChI=1S/C22H23Cl2NO4/c23-18-3-1-4-19(24)16(18)12-28-15-5-6-17-20(11-15)29-14-22(17)8-2-9-25(13-22)10-7-21(26)27/h1,3-6,11H,2,7-10,12-14H2,(H,26,27)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-K1-human-S1P1-Aeqorin assay was bought from Euroscreen Fast, Brussels (Euroscreen, Technical dossier, Human S1P1 (Edg1) receptor, DNA clone a...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))
BDBM321297
PNG
(US10179791, Compound 29)
Show SMILES OC(=O)CCN1CCC2(COc3cc(OCc4c(Cl)cccc4Cl)ccc23)CC1
Show InChI InChI=1S/C22H23Cl2NO4/c23-18-2-1-3-19(24)16(18)13-28-15-4-5-17-20(12-15)29-14-22(17)7-10-25(11-8-22)9-6-21(26)27/h1-5,12H,6-11,13-14H2,(H,26,27)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-K1-human-S1P1-Aeqorin assay was bought from Euroscreen Fast, Brussels (Euroscreen, Technical dossier, Human S1P1 (Edg1) receptor, DNA clone a...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 5


(Homo sapiens (human))
BDBM321299
PNG
(US10179791, Compound 51)
Show SMILES CCc1ccc(Cl)c(COc2ccc3c(OCC33CCN(CCC(O)=O)CC3)c2)c1
Show InChI InChI=1S/C24H28ClNO4/c1-2-17-3-6-21(25)18(13-17)15-29-19-4-5-20-22(14-19)30-16-24(20)8-11-26(12-9-24)10-7-23(27)28/h3-6,13-14H,2,7-12,15-16H2,1H3,(H,27,28)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-human-S1P5-Aeqorin assay was bought from Euroscreen, Brussels (Euroscreen, Technical dossier, Human Lysophospholid S1P5 (Edg8) receptor, DNA ...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 5


(Homo sapiens (human))
BDBM321303
PNG
(US10179791, Compound 75)
Show SMILES OC(=O)CCN1CCC2(COc3cc(OCc4c(Cl)cccc4C4CC4)ccc23)CC1
Show InChI InChI=1S/C25H28ClNO4/c26-22-3-1-2-19(17-4-5-17)20(22)15-30-18-6-7-21-23(14-18)31-16-25(21)9-12-27(13-10-25)11-8-24(28)29/h1-3,6-7,14,17H,4-5,8-13,15-16H2,(H,28,29)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-human-S1P5-Aeqorin assay was bought from Euroscreen, Brussels (Euroscreen, Technical dossier, Human Lysophospholid S1P5 (Edg8) receptor, DNA ...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))
BDBM321303
PNG
(US10179791, Compound 75)
Show SMILES OC(=O)CCN1CCC2(COc3cc(OCc4c(Cl)cccc4C4CC4)ccc23)CC1
Show InChI InChI=1S/C25H28ClNO4/c26-22-3-1-2-19(17-4-5-17)20(22)15-30-18-6-7-21-23(14-18)31-16-25(21)9-12-27(13-10-25)11-8-24(28)29/h1-3,6-7,14,17H,4-5,8-13,15-16H2,(H,28,29)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-K1-human-S1P1-Aeqorin assay was bought from Euroscreen Fast, Brussels (Euroscreen, Technical dossier, Human S1P1 (Edg1) receptor, DNA clone a...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 5


(Homo sapiens (human))
BDBM321304
PNG
(US10179791, Compound 77)
Show SMILES OC(=O)CCN1CCC2(COc3cc(OCc4c(Cl)cccc4OC(F)(F)F)ccc23)CC1
Show InChI InChI=1S/C23H23ClF3NO5/c24-18-2-1-3-19(33-23(25,26)27)16(18)13-31-15-4-5-17-20(12-15)32-14-22(17)7-10-28(11-8-22)9-6-21(29)30/h1-5,12H,6-11,13-14H2,(H,29,30)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-human-S1P5-Aeqorin assay was bought from Euroscreen, Brussels (Euroscreen, Technical dossier, Human Lysophospholid S1P5 (Edg8) receptor, DNA ...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))
BDBM321304
PNG
(US10179791, Compound 77)
Show SMILES OC(=O)CCN1CCC2(COc3cc(OCc4c(Cl)cccc4OC(F)(F)F)ccc23)CC1
Show InChI InChI=1S/C23H23ClF3NO5/c24-18-2-1-3-19(33-23(25,26)27)16(18)13-31-15-4-5-17-20(12-15)32-14-22(17)7-10-28(11-8-22)9-6-21(29)30/h1-5,12H,6-11,13-14H2,(H,29,30)
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n/an/an/an/a 6.31E+3n/an/an/an/a



AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-K1-human-S1P1-Aeqorin assay was bought from Euroscreen Fast, Brussels (Euroscreen, Technical dossier, Human S1P1 (Edg1) receptor, DNA clone a...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))
BDBM321310
PNG
(US10179791, Compound 121)
Show SMILES OC(=O)CCCN1CCC2(COc3cc(OCc4c(Cl)cccc4C4CC4)ccc23)CC1
Show InChI InChI=1S/C26H30ClNO4/c27-23-4-1-3-20(18-6-7-18)21(23)16-31-19-8-9-22-24(15-19)32-17-26(22)10-13-28(14-11-26)12-2-5-25(29)30/h1,3-4,8-9,15,18H,2,5-7,10-14,16-17H2,(H,29,30)
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n/an/an/an/a 5.01E+3n/an/an/an/a



AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-K1-human-S1P1-Aeqorin assay was bought from Euroscreen Fast, Brussels (Euroscreen, Technical dossier, Human S1P1 (Edg1) receptor, DNA clone a...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))
BDBM321311
PNG
(US10179791, Compound 127)
Show SMILES CC(C)c1cccc(Cl)c1COc1ccc2c(OCC22CCN(CCCC(O)=O)CC2)c1
Show InChI InChI=1S/C26H32ClNO4/c1-18(2)20-5-3-6-23(27)21(20)16-31-19-8-9-22-24(15-19)32-17-26(22)10-13-28(14-11-26)12-4-7-25(29)30/h3,5-6,8-9,15,18H,4,7,10-14,16-17H2,1-2H3,(H,29,30)
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n/an/an/an/a 7.94E+3n/an/an/an/a



AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-K1-human-S1P1-Aeqorin assay was bought from Euroscreen Fast, Brussels (Euroscreen, Technical dossier, Human S1P1 (Edg1) receptor, DNA clone a...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 5


(Homo sapiens (human))
BDBM321315
PNG
(US10179791, Compound 136)
Show SMILES CCc1cccc(Cl)c1COc1ccc2c(OCC22CCN(CCC(O)=O)CC2)c1F
Show InChI InChI=1S/C24H27ClFNO4/c1-2-16-4-3-5-19(25)17(16)14-30-20-7-6-18-23(22(20)26)31-15-24(18)9-12-27(13-10-24)11-8-21(28)29/h3-7H,2,8-15H2,1H3,(H,28,29)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-human-S1P5-Aeqorin assay was bought from Euroscreen, Brussels (Euroscreen, Technical dossier, Human Lysophospholid S1P5 (Edg8) receptor, DNA ...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 5


(Homo sapiens (human))
BDBM321320
PNG
(US10179791, Compound 160)
Show SMILES OC(=O)CCN1CCC2(COc3cc(\C=C\c4c(Cl)cccc4Cl)ccc23)CC1
Show InChI InChI=1S/C23H23Cl2NO3/c24-19-2-1-3-20(25)17(19)6-4-16-5-7-18-21(14-16)29-15-23(18)9-12-26(13-10-23)11-8-22(27)28/h1-7,14H,8-13,15H2,(H,27,28)/b6-4+
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-human-S1P5-Aeqorin assay was bought from Euroscreen, Brussels (Euroscreen, Technical dossier, Human Lysophospholid S1P5 (Edg8) receptor, DNA ...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 3


(Homo sapiens (human))
BDBM321320
PNG
(US10179791, Compound 160)
Show SMILES OC(=O)CCN1CCC2(COc3cc(\C=C\c4c(Cl)cccc4Cl)ccc23)CC1
Show InChI InChI=1S/C23H23Cl2NO3/c24-19-2-1-3-20(25)17(19)6-4-16-5-7-18-21(14-16)29-15-23(18)9-12-26(13-10-23)11-8-22(27)28/h1-7,14H,8-13,15H2,(H,27,28)/b6-4+
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-human-S1P3-Aeqorin assay (CHO/Gα16/AEQ/h-S1P3) was established at Solvay Pharmaceuticals. The plasmid DNA coding for the S1P3 receptor (...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))
BDBM321326
PNG
(US10179791, Compound 248)
Show SMILES OC(=O)CCN1CCC2(COc3cc(Oc4c(Cl)cccc4Cl)ccc23)CC1
Show InChI InChI=1S/C21H21Cl2NO4/c22-16-2-1-3-17(23)20(16)28-14-4-5-15-18(12-14)27-13-21(15)7-10-24(11-8-21)9-6-19(25)26/h1-5,12H,6-11,13H2,(H,25,26)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-K1-Human S1P1-c-AMP assay was performed at Euroscreenfast, Brussels (Euroscreen, Human S1P1 coupling Gi/0, (Edg1) receptor, catalog no: FAST-...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 5


(Homo sapiens (human))
BDBM321328
PNG
(US10179791, Compound 253)
Show SMILES OC(=O)CCN1CCC2(COc3cc(OCc4c(F)cccc4C4CC4)ccc23)CC1
Show InChI InChI=1S/C25H28FNO4/c26-22-3-1-2-19(17-4-5-17)20(22)15-30-18-6-7-21-23(14-18)31-16-25(21)9-12-27(13-10-25)11-8-24(28)29/h1-3,6-7,14,17H,4-5,8-13,15-16H2,(H,28,29)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-human-S1P5-Aeqorin assay was bought from Euroscreen, Brussels (Euroscreen, Technical dossier, Human Lysophospholid S1P5 (Edg8) receptor, DNA ...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 5


(Homo sapiens (human))
BDBM321329
PNG
(US10179791, Compound 258)
Show SMILES CCc1cccc(CC)c1COc1ccc2c(OCC22CCN(CCC(O)=O)CC2)c1
Show InChI InChI=1S/C26H33NO4/c1-3-19-6-5-7-20(4-2)22(19)17-30-21-8-9-23-24(16-21)31-18-26(23)11-14-27(15-12-26)13-10-25(28)29/h5-9,16H,3-4,10-15,17-18H2,1-2H3,(H,28,29)
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n/an/an/an/a 15.8n/an/an/an/a



AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-human-S1P5-Aeqorin assay was bought from Euroscreen, Brussels (Euroscreen, Technical dossier, Human Lysophospholid S1P5 (Edg8) receptor, DNA ...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 5


(Homo sapiens (human))
BDBM321332
PNG
(US10179791, Compound 289)
Show SMILES OC(=O)CCN1CCC2(COc3cc(OCc4c(Cl)cccc4Cl)c(F)cc23)CC1
Show InChI InChI=1S/C22H22Cl2FNO4/c23-16-2-1-3-17(24)14(16)12-29-20-11-19-15(10-18(20)25)22(13-30-19)5-8-26(9-6-22)7-4-21(27)28/h1-3,10-11H,4-9,12-13H2,(H,27,28)
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n/an/an/an/a 31.6n/an/an/an/a



AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-human-S1P5-Aeqorin assay was bought from Euroscreen, Brussels (Euroscreen, Technical dossier, Human Lysophospholid S1P5 (Edg8) receptor, DNA ...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 5


(Homo sapiens (human))
BDBM321297
PNG
(US10179791, Compound 29)
Show SMILES OC(=O)CCN1CCC2(COc3cc(OCc4c(Cl)cccc4Cl)ccc23)CC1
Show InChI InChI=1S/C22H23Cl2NO4/c23-18-2-1-3-19(24)16(18)13-28-15-4-5-17-20(12-15)29-14-22(17)7-10-25(11-8-22)9-6-21(26)27/h1-5,12H,6-11,13-14H2,(H,26,27)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-human-S1P5-Aeqorin assay was bought from Euroscreen, Brussels (Euroscreen, Technical dossier, Human Lysophospholid S1P5 (Edg8) receptor, DNA ...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))
BDBM321298
PNG
(US10179791, Compound 38)
Show SMILES OC(=O)CCN1CCC2(COc3cc(OCc4c(F)cccc4Cl)ccc23)CC1
Show InChI InChI=1S/C22H23ClFNO4/c23-18-2-1-3-19(24)16(18)13-28-15-4-5-17-20(12-15)29-14-22(17)7-10-25(11-8-22)9-6-21(26)27/h1-5,12H,6-11,13-14H2,(H,26,27)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-K1-Human S1P1-c-AMP assay was performed at Euroscreenfast, Brussels (Euroscreen, Human S1P1 coupling Gi/0, (Edg1) receptor, catalog no: FAST-...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 3


(Homo sapiens (human))
BDBM321299
PNG
(US10179791, Compound 51)
Show SMILES CCc1ccc(Cl)c(COc2ccc3c(OCC33CCN(CCC(O)=O)CC3)c2)c1
Show InChI InChI=1S/C24H28ClNO4/c1-2-17-3-6-21(25)18(13-17)15-29-19-4-5-20-22(14-19)30-16-24(20)8-11-26(12-9-24)10-7-23(27)28/h3-6,13-14H,2,7-12,15-16H2,1H3,(H,27,28)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-human-S1P3-Aeqorin assay (CHO/Gα16/AEQ/h-S1P3) was established at Solvay Pharmaceuticals. The plasmid DNA coding for the S1P3 receptor (...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 5


(Homo sapiens (human))
BDBM321300
PNG
(US10179791, Compound 59)
Show SMILES Cc1cc(Cl)c(COc2ccc3c(OCC33CCN(CCC(O)=O)CC3)c2)c(Cl)c1
Show InChI InChI=1S/C23H25Cl2NO4/c1-15-10-19(24)17(20(25)11-15)13-29-16-2-3-18-21(12-16)30-14-23(18)5-8-26(9-6-23)7-4-22(27)28/h2-3,10-12H,4-9,13-14H2,1H3,(H,27,28)
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n/an/an/an/a 15.8n/an/an/an/a



AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-human-S1P5-Aeqorin assay was bought from Euroscreen, Brussels (Euroscreen, Technical dossier, Human Lysophospholid S1P5 (Edg8) receptor, DNA ...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 5


(Homo sapiens (human))
BDBM321301
PNG
(US10179791, Compound 68)
Show SMILES CCc1ccc(Cl)c(COc2ccc3c(OCC33CCN(CCC(O)=O)CC3)c2)c1Cl
Show InChI InChI=1S/C24H27Cl2NO4/c1-2-16-3-6-20(25)18(23(16)26)14-30-17-4-5-19-21(13-17)31-15-24(19)8-11-27(12-9-24)10-7-22(28)29/h3-6,13H,2,7-12,14-15H2,1H3,(H,28,29)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-human-S1P5-Aeqorin assay was bought from Euroscreen, Brussels (Euroscreen, Technical dossier, Human Lysophospholid S1P5 (Edg8) receptor, DNA ...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 3


(Homo sapiens (human))
BDBM321303
PNG
(US10179791, Compound 75)
Show SMILES OC(=O)CCN1CCC2(COc3cc(OCc4c(Cl)cccc4C4CC4)ccc23)CC1
Show InChI InChI=1S/C25H28ClNO4/c26-22-3-1-2-19(17-4-5-17)20(22)15-30-18-6-7-21-23(14-18)31-16-25(21)9-12-27(13-10-25)11-8-24(28)29/h1-3,6-7,14,17H,4-5,8-13,15-16H2,(H,28,29)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-human-S1P3-Aeqorin assay (CHO/Gα16/AEQ/h-S1P3) was established at Solvay Pharmaceuticals. The plasmid DNA coding for the S1P3 receptor (...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 5


(Homo sapiens (human))
BDBM321310
PNG
(US10179791, Compound 121)
Show SMILES OC(=O)CCCN1CCC2(COc3cc(OCc4c(Cl)cccc4C4CC4)ccc23)CC1
Show InChI InChI=1S/C26H30ClNO4/c27-23-4-1-3-20(18-6-7-18)21(23)16-31-19-8-9-22-24(15-19)32-17-26(22)10-13-28(14-11-26)12-2-5-25(29)30/h1,3-4,8-9,15,18H,2,5-7,10-14,16-17H2,(H,29,30)
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n/an/an/an/a 79.4n/an/an/an/a



AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-human-S1P5-Aeqorin assay was bought from Euroscreen, Brussels (Euroscreen, Technical dossier, Human Lysophospholid S1P5 (Edg8) receptor, DNA ...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))
BDBM321314
PNG
(US10179791, Compound 132)
Show SMILES OC(=O)CCN1CCC2(COc3c2ccc(OCc2c(Cl)cc(Cl)cc2Cl)c3F)CC1
Show InChI InChI=1S/C22H21Cl3FNO4/c23-13-9-16(24)14(17(25)10-13)11-30-18-2-1-15-21(20(18)26)31-12-22(15)4-7-27(8-5-22)6-3-19(28)29/h1-2,9-10H,3-8,11-12H2,(H,28,29)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-K1-human-S1P1-Aeqorin assay was bought from Euroscreen Fast, Brussels (Euroscreen, Technical dossier, Human S1P1 (Edg1) receptor, DNA clone a...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))
BDBM321318
PNG
(US10179791, Compound 143)
Show SMILES OC(=O)CCN1CCC2(COc3cc(SCc4c(Cl)cc(Cl)cc4Cl)ccc23)CC1
Show InChI InChI=1S/C22H22Cl3NO3S/c23-14-9-18(24)16(19(25)10-14)12-30-15-1-2-17-20(11-15)29-13-22(17)4-7-26(8-5-22)6-3-21(27)28/h1-2,9-11H,3-8,12-13H2,(H,27,28)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-K1-human-S1P1-Aeqorin assay was bought from Euroscreen Fast, Brussels (Euroscreen, Technical dossier, Human S1P1 (Edg1) receptor, DNA clone a...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))
BDBM321320
PNG
(US10179791, Compound 160)
Show SMILES OC(=O)CCN1CCC2(COc3cc(\C=C\c4c(Cl)cccc4Cl)ccc23)CC1
Show InChI InChI=1S/C23H23Cl2NO3/c24-19-2-1-3-20(25)17(19)6-4-16-5-7-18-21(14-16)29-15-23(18)9-12-26(13-10-23)11-8-22(27)28/h1-7,14H,8-13,15H2,(H,27,28)/b6-4+
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-K1-Human S1P1-c-AMP assay was performed at Euroscreenfast, Brussels (Euroscreen, Human S1P1 coupling Gi/0, (Edg1) receptor, catalog no: FAST-...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 3


(Homo sapiens (human))
BDBM321322
PNG
(US10179791, Compound 176)
Show SMILES OC(=O)CN1CCC2(COc3cc(ccc23)C2CC2c2c(Cl)cccc2Cl)CC1
Show InChI InChI=1S/C23H23Cl2NO3/c24-18-2-1-3-19(25)22(18)16-11-15(16)14-4-5-17-20(10-14)29-13-23(17)6-8-26(9-7-23)12-21(27)28/h1-5,10,15-16H,6-9,11-13H2,(H,27,28)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-human-S1P3-Aeqorin assay (CHO/Gα16/AEQ/h-S1P3) was established at Solvay Pharmaceuticals. The plasmid DNA coding for the S1P3 receptor (...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))
BDBM321328
PNG
(US10179791, Compound 253)
Show SMILES OC(=O)CCN1CCC2(COc3cc(OCc4c(F)cccc4C4CC4)ccc23)CC1
Show InChI InChI=1S/C25H28FNO4/c26-22-3-1-2-19(17-4-5-17)20(22)15-30-18-6-7-21-23(14-18)31-16-25(21)9-12-27(13-10-25)11-8-24(28)29/h1-3,6-7,14,17H,4-5,8-13,15-16H2,(H,28,29)
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n/an/an/an/a 2.51E+3n/an/an/an/a



AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-K1-human-S1P1-Aeqorin assay was bought from Euroscreen Fast, Brussels (Euroscreen, Technical dossier, Human S1P1 (Edg1) receptor, DNA clone a...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))
BDBM321329
PNG
(US10179791, Compound 258)
Show SMILES CCc1cccc(CC)c1COc1ccc2c(OCC22CCN(CCC(O)=O)CC2)c1
Show InChI InChI=1S/C26H33NO4/c1-3-19-6-5-7-20(4-2)22(19)17-30-21-8-9-23-24(16-21)31-18-26(23)11-14-27(15-12-26)13-10-25(28)29/h5-9,16H,3-4,10-15,17-18H2,1-2H3,(H,28,29)
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n/an/an/an/a 2.51E+3n/an/an/an/a



AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-K1-human-S1P1-Aeqorin assay was bought from Euroscreen Fast, Brussels (Euroscreen, Technical dossier, Human S1P1 (Edg1) receptor, DNA clone a...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 3


(Homo sapiens (human))
BDBM321331
PNG
(US10179791, Compound 277)
Show SMILES CCCCCCCCOc1ccc2c(OCC22CCN(CCC(O)=O)CC2)c1F
Show InChI InChI=1S/C23H34FNO4/c1-2-3-4-5-6-7-16-28-19-9-8-18-22(21(19)24)29-17-23(18)11-14-25(15-12-23)13-10-20(26)27/h8-9H,2-7,10-17H2,1H3,(H,26,27)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-human-S1P3-Aeqorin assay (CHO/Gα16/AEQ/h-S1P3) was established at Solvay Pharmaceuticals. The plasmid DNA coding for the S1P3 receptor (...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 5


(Homo sapiens (human))
BDBM321333
PNG
(US10179791, Compound 296)
Show SMILES CCc1cccc(Cl)c1CSc1ccc2c(OCC22CCN(CCC(O)=O)CC2)c1F
Show InChI InChI=1S/C24H27ClFNO3S/c1-2-16-4-3-5-19(25)17(16)14-31-20-7-6-18-23(22(20)26)30-15-24(18)9-12-27(13-10-24)11-8-21(28)29/h3-7H,2,8-15H2,1H3,(H,28,29)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-human-S1P5-Aeqorin assay was bought from Euroscreen, Brussels (Euroscreen, Technical dossier, Human Lysophospholid S1P5 (Edg8) receptor, DNA ...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 3


(Homo sapiens (human))
BDBM321336
PNG
(US10179791, Compound 303)
Show SMILES OC(=O)CCN1CCC2(COc3cc(ccc23)C#Cc2ccccc2)CC1
Show InChI InChI=1S/C23H23NO3/c25-22(26)10-13-24-14-11-23(12-15-24)17-27-21-16-19(8-9-20(21)23)7-6-18-4-2-1-3-5-18/h1-5,8-9,16H,10-15,17H2,(H,25,26)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-human-S1P3-Aeqorin assay (CHO/Gα16/AEQ/h-S1P3) was established at Solvay Pharmaceuticals. The plasmid DNA coding for the S1P3 receptor (...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 3


(Homo sapiens (human))
BDBM321297
PNG
(US10179791, Compound 29)
Show SMILES OC(=O)CCN1CCC2(COc3cc(OCc4c(Cl)cccc4Cl)ccc23)CC1
Show InChI InChI=1S/C22H23Cl2NO4/c23-18-2-1-3-19(24)16(18)13-28-15-4-5-17-20(12-15)29-14-22(17)7-10-25(11-8-22)9-6-21(26)27/h1-5,12H,6-11,13-14H2,(H,26,27)
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n/an/an/an/a<3.16E+4n/an/an/an/a



AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-human-S1P3-Aeqorin assay (CHO/Gα16/AEQ/h-S1P3) was established at Solvay Pharmaceuticals. The plasmid DNA coding for the S1P3 receptor (...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 5


(Homo sapiens (human))
BDBM321306
PNG
(US10179791, Compound 100)
Show SMILES CC(CN1CCC2(COc3cc(OCc4c(Cl)cccc4Cl)ccc23)CC1)C(O)=O
Show InChI InChI=1S/C23H25Cl2NO4/c1-15(22(27)28)12-26-9-7-23(8-10-26)14-30-21-11-16(5-6-18(21)23)29-13-17-19(24)3-2-4-20(17)25/h2-6,11,15H,7-10,12-14H2,1H3,(H,27,28)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-human-S1P5-Aeqorin assay was bought from Euroscreen, Brussels (Euroscreen, Technical dossier, Human Lysophospholid S1P5 (Edg8) receptor, DNA ...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 5


(Homo sapiens (human))
BDBM321307
PNG
(US10179791, Compound 102)
Show SMILES CC(CN1CCC2(COc3cc(OCc4c(Cl)cc(Cl)cc4Cl)ccc23)CC1)C(O)=O
Show InChI InChI=1S/C23H24Cl3NO4/c1-14(22(28)29)11-27-6-4-23(5-7-27)13-31-21-10-16(2-3-18(21)23)30-12-17-19(25)8-15(24)9-20(17)26/h2-3,8-10,14H,4-7,11-13H2,1H3,(H,28,29)
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n/an/an/an/a 15.8n/an/an/an/a



AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-human-S1P5-Aeqorin assay was bought from Euroscreen, Brussels (Euroscreen, Technical dossier, Human Lysophospholid S1P5 (Edg8) receptor, DNA ...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))
BDBM321312
PNG
(US10179791, Compound 128)
Show SMILES OC(=O)CCCN1CCC2(COc3cc(OCc4c(Cl)cccc4Cl)ccc23)CC1
Show InChI InChI=1S/C23H25Cl2NO4/c24-19-3-1-4-20(25)17(19)14-29-16-6-7-18-21(13-16)30-15-23(18)8-11-26(12-9-23)10-2-5-22(27)28/h1,3-4,6-7,13H,2,5,8-12,14-15H2,(H,27,28)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-K1-Human S1P1-c-AMP assay was performed at Euroscreenfast, Brussels (Euroscreen, Human S1P1 coupling Gi/0, (Edg1) receptor, catalog no: FAST-...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))
BDBM321313
PNG
(US10179791, Compound 129)
Show SMILES Cc1c2OCC3(CCN(CCC(O)=O)CC3)c2ccc1OCc1c(Cl)cccc1Cl
Show InChI InChI=1S/C23H25Cl2NO4/c1-15-20(29-13-16-18(24)3-2-4-19(16)25)6-5-17-22(15)30-14-23(17)8-11-26(12-9-23)10-7-21(27)28/h2-6H,7-14H2,1H3,(H,27,28)
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n/an/an/an/a<3.16E+3n/an/an/an/a



AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-K1-Human S1P1-c-AMP assay was performed at Euroscreenfast, Brussels (Euroscreen, Human S1P1 coupling Gi/0, (Edg1) receptor, catalog no: FAST-...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 5


(Homo sapiens (human))
BDBM321321
PNG
(US10179791, Compound 171)
Show SMILES OC(=O)CCN1CCC2(COc3cc(\C=C\c4ccccc4F)ccc23)CC1
Show InChI InChI=1S/C23H24FNO3/c24-20-4-2-1-3-18(20)7-5-17-6-8-19-21(15-17)28-16-23(19)10-13-25(14-11-23)12-9-22(26)27/h1-8,15H,9-14,16H2,(H,26,27)/b7-5+
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-human-S1P5-Aeqorin assay was bought from Euroscreen, Brussels (Euroscreen, Technical dossier, Human Lysophospholid S1P5 (Edg8) receptor, DNA ...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 5


(Homo sapiens (human))
BDBM321322
PNG
(US10179791, Compound 176)
Show SMILES OC(=O)CN1CCC2(COc3cc(ccc23)C2CC2c2c(Cl)cccc2Cl)CC1
Show InChI InChI=1S/C23H23Cl2NO3/c24-18-2-1-3-19(25)22(18)16-11-15(16)14-4-5-17-20(10-14)29-13-23(17)6-8-26(9-7-23)12-21(27)28/h1-5,10,15-16H,6-9,11-13H2,(H,27,28)
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n/an/an/an/a 25.1n/an/an/an/a



AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-human-S1P5-Aeqorin assay was bought from Euroscreen, Brussels (Euroscreen, Technical dossier, Human Lysophospholid S1P5 (Edg8) receptor, DNA ...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 3


(Homo sapiens (human))
BDBM321327
PNG
(US10179791, Compound 252)
Show SMILES CC(C)c1cccc(F)c1COc1ccc2c(OCC22CCN(CCC(O)=O)CC2)c1
Show InChI InChI=1S/C25H30FNO4/c1-17(2)19-4-3-5-22(26)20(19)15-30-18-6-7-21-23(14-18)31-16-25(21)9-12-27(13-10-25)11-8-24(28)29/h3-7,14,17H,8-13,15-16H2,1-2H3,(H,28,29)
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n/an/an/an/a 5.01E+3n/an/an/an/a



AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-human-S1P3-Aeqorin assay (CHO/Gα16/AEQ/h-S1P3) was established at Solvay Pharmaceuticals. The plasmid DNA coding for the S1P3 receptor (...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))
BDBM321332
PNG
(US10179791, Compound 289)
Show SMILES OC(=O)CCN1CCC2(COc3cc(OCc4c(Cl)cccc4Cl)c(F)cc23)CC1
Show InChI InChI=1S/C22H22Cl2FNO4/c23-16-2-1-3-17(24)14(16)12-29-20-11-19-15(10-18(20)25)22(13-30-19)5-8-26(9-6-22)7-4-21(27)28/h1-3,10-11H,4-9,12-13H2,(H,27,28)
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n/an/an/an/a<3.16E+4n/an/an/an/a



AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-K1-human-S1P1-Aeqorin assay was bought from Euroscreen Fast, Brussels (Euroscreen, Technical dossier, Human S1P1 (Edg1) receptor, DNA clone a...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))
BDBM321333
PNG
(US10179791, Compound 296)
Show SMILES CCc1cccc(Cl)c1CSc1ccc2c(OCC22CCN(CCC(O)=O)CC2)c1F
Show InChI InChI=1S/C24H27ClFNO3S/c1-2-16-4-3-5-19(25)17(16)14-31-20-7-6-18-23(22(20)26)30-15-24(18)9-12-27(13-10-24)11-8-21(28)29/h3-7H,2,8-15H2,1H3,(H,28,29)
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n/an/an/an/a 39.8n/an/an/an/a



AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-K1-human-S1P1-Aeqorin assay was bought from Euroscreen Fast, Brussels (Euroscreen, Technical dossier, Human S1P1 (Edg1) receptor, DNA clone a...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 3


(Homo sapiens (human))
BDBM321335
PNG
(US10179791, Compound 299)
Show SMILES OC(=O)CCN1CCC2(COc3cc(ccc23)S(=O)(=O)Cc2c(Cl)cccc2Cl)CC1
Show InChI InChI=1S/C22H23Cl2NO5S/c23-18-2-1-3-19(24)16(18)13-31(28,29)15-4-5-17-20(12-15)30-14-22(17)7-10-25(11-8-22)9-6-21(26)27/h1-5,12H,6-11,13-14H2,(H,26,27)
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n/an/an/an/a<1.00E+4n/an/an/an/a



AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-human-S1P3-Aeqorin assay (CHO/Gα16/AEQ/h-S1P3) was established at Solvay Pharmaceuticals. The plasmid DNA coding for the S1P3 receptor (...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))
BDBM321336
PNG
(US10179791, Compound 303)
Show SMILES OC(=O)CCN1CCC2(COc3cc(ccc23)C#Cc2ccccc2)CC1
Show InChI InChI=1S/C23H23NO3/c25-22(26)10-13-24-14-11-23(12-15-24)17-27-21-16-19(8-9-20(21)23)7-6-18-4-2-1-3-5-18/h1-5,8-9,16H,10-15,17H2,(H,25,26)
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AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-K1-human-S1P1-Aeqorin assay was bought from Euroscreen Fast, Brussels (Euroscreen, Technical dossier, Human S1P1 (Edg1) receptor, DNA clone a...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 5


(Homo sapiens (human))
BDBM321338
PNG
(US10179791, Compound 321)
Show SMILES OC(=O)CCN1CCCC2(COc3cc(OCc4c(Cl)cccc4Cl)ccc23)C1
Show InChI InChI=1S/C22H23Cl2NO4/c23-18-3-1-4-19(24)16(18)12-28-15-5-6-17-20(11-15)29-14-22(17)8-2-9-25(13-22)10-7-21(26)27/h1,3-6,11H,2,7-10,12-14H2,(H,26,27)
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n/an/an/an/a 79.4n/an/an/an/a



AbbVie B.V.; AbbVie, Inc.

US Patent


Assay Description
The CHO-human-S1P5-Aeqorin assay was bought from Euroscreen, Brussels (Euroscreen, Technical dossier, Human Lysophospholid S1P5 (Edg8) receptor, DNA ...


US Patent US10179791 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%