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Patent code US10183009

Compile Data Set for Download or QSAR
Found 122 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321430
PNG
(6-[(E)-but-2-enyl]-4-[3-isopropoxy-4-(morpholine-4...)
Show SMILES C\C=C\Cn1cc(-c2ccc(C(=O)N3CCOCC3)c(OC(C)C)c2)c2cc(C)[nH]c2c1=O
Show InChI InChI=1S/C26H31N3O4/c1-5-6-9-29-16-22(21-14-18(4)27-24(21)26(29)31)19-7-8-20(23(15-19)33-17(2)3)25(30)28-10-12-32-13-11-28/h5-8,14-17,27H,9-13H2,1-4H3/b6-5+
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n/an/a 3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321429
PNG
((E)-1-(4-(6-(but-2-en-1-yl)-2-methyl-7-oxo-6,7-dih...)
Show SMILES C\C=C\Cn1cc(-c2ccc(C(=O)N3CCC(CC3)C(N)=O)c(Cl)c2)c2cc(C)[nH]c2c1=O
Show InChI InChI=1S/C25H27ClN4O3/c1-3-4-9-30-14-20(19-12-15(2)28-22(19)25(30)33)17-5-6-18(21(26)13-17)24(32)29-10-7-16(8-11-29)23(27)31/h3-6,12-14,16,28H,7-11H2,1-2H3,(H2,27,31)/b4-3+
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n/an/a 3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321411
PNG
(6-[(E)-but-2-enyl]-4-[3-methoxy-4-(morpholine-4-ca...)
Show SMILES COc1cc(ccc1C(=O)N1CCOCC1)-c1cn(C\C=C\C)c(=O)c2[nH]c(C)cc12
Show InChI InChI=1S/C24H27N3O4/c1-4-5-8-27-15-20(19-13-16(2)25-22(19)24(27)29)17-6-7-18(21(14-17)30-3)23(28)26-9-11-31-12-10-26/h4-7,13-15,25H,8-12H2,1-3H3/b5-4+
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321438
PNG
(3-[6-[(E)-but-2-enyl]-2-methyl-7-oxo-1H-pyrrolo[2,...)
Show SMILES COc1ccc(cc1-c1cn(C\C=C\C)c(=O)c2[nH]c(C)cc12)C(=O)NCc1cncnc1
Show InChI InChI=1S/C25H25N5O3/c1-4-5-8-30-14-21(20-9-16(2)29-23(20)25(30)32)19-10-18(6-7-22(19)33-3)24(31)28-13-17-11-26-15-27-12-17/h4-7,9-12,14-15,29H,8,13H2,1-3H3,(H,28,31)/b5-4+
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321432
PNG
((E)-6-(but-2-en-1-yl)-4-(3-chloro-4-(piperazine-1-...)
Show SMILES C\C=C\Cn1cc(-c2ccc(C(=O)N3CCNCC3)c(Cl)c2)c2cc(C)[nH]c2c1=O
Show InChI InChI=1S/C23H25ClN4O2/c1-3-4-9-28-14-19(18-12-15(2)26-21(18)23(28)30)16-5-6-17(20(24)13-16)22(29)27-10-7-25-8-11-27/h3-6,12-14,25-26H,7-11H2,1-2H3/b4-3+
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n/an/a 4n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321424
PNG
(6-[(E)-but-2-enyl]-4-[2,5-dimethoxy-4-(morpholine-...)
Show SMILES COc1cc(c(OC)cc1C(=O)N1CCOCC1)-c1cn(C\C=C\C)c(=O)c2[nH]c(C)cc12
Show InChI InChI=1S/C25H29N3O5/c1-5-6-7-28-15-20(18-12-16(2)26-23(18)25(28)30)17-13-22(32-4)19(14-21(17)31-3)24(29)27-8-10-33-11-9-27/h5-6,12-15,26H,7-11H2,1-4H3/b6-5+
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321412
PNG
(6-[(E)-but-2-enyl]-4-[3-chloro-4-(morpholine-4-car...)
Show SMILES C\C=C\Cn1cc(-c2ccc(C(=O)N3CCOCC3)c(Cl)c2)c2cc(C)[nH]c2c1=O
Show InChI InChI=1S/C23H24ClN3O3/c1-3-4-7-27-14-19(18-12-15(2)25-21(18)23(27)29)16-5-6-17(20(24)13-16)22(28)26-8-10-30-11-9-26/h3-6,12-14,25H,7-11H2,1-2H3/b4-3+
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321433
PNG
((E)-4-(4-(3-(3-amino-1H-pyrazol-1-yl)azetidine-1-c...)
Show SMILES C\C=C\Cn1cc(-c2ccc(C(=O)N3CC(C3)n3ccc(N)n3)c(Cl)c2)c2cc(C)[nH]c2c1=O
Show InChI InChI=1S/C25H25ClN6O2/c1-3-4-8-30-14-20(19-10-15(2)28-23(19)25(30)34)16-5-6-18(21(26)11-16)24(33)31-12-17(13-31)32-9-7-22(27)29-32/h3-7,9-11,14,17,28H,8,12-13H2,1-2H3,(H2,27,29)/b4-3+
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321431
PNG
(6-[(E)-but-2-enyl]-4-[3-(cyclopropylmethoxy)-4-(mo...)
Show SMILES C\C=C\CN1C=C2NC(C)C=C2C(=C1)c1ccc(C(=O)N2CCOCC2)c(OCC2CC2)c1
Show InChI InChI=1S/C27H33N3O3/c1-3-4-9-29-16-24(23-14-19(2)28-25(23)17-29)21-7-8-22(26(15-21)33-18-20-5-6-20)27(31)30-10-12-32-13-11-30/h3-4,7-8,14-17,19-20,28H,5-6,9-13,18H2,1-2H3/b4-3+
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321422
PNG
(5-[6-[(E)-but-2-enyl]-2-methyl-7-oxo-1H-pyrrolo[2,...)
Show SMILES C\C=C\Cn1cc(-c2ccc(C(=O)N3CCOCC3)c(c2)C#N)c2cc(C)[nH]c2c1=O
Show InChI InChI=1S/C24H24N4O3/c1-3-4-7-28-15-21(20-12-16(2)26-22(20)24(28)30)17-5-6-19(18(13-17)14-25)23(29)27-8-10-31-11-9-27/h3-6,12-13,15,26H,7-11H2,1-2H3/b4-3+
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n/an/a 6n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321425
PNG
(3-[6-[(E)-but-2-enyl]-2-methyl-7-oxo-1H-pyrrolo[2,...)
Show SMILES COc1ccc(cc1-c1cn(C\C=C\C)c(=O)c2[nH]c(C)cc12)C(=O)NCc1cnccn1
Show InChI InChI=1S/C25H25N5O3/c1-4-5-10-30-15-21(20-11-16(2)29-23(20)25(30)32)19-12-17(6-7-22(19)33-3)24(31)28-14-18-13-26-8-9-27-18/h4-9,11-13,15,29H,10,14H2,1-3H3,(H,28,31)/b5-4+
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321437
PNG
((E)-6-(but-2-en-1-yl)-4-(4-(2-hydroxypropan-2-yl)-...)
Show SMILES COc1cc(c(OC)cc1-c1cn(C\C=C\C)c(=O)c2[nH]c(C)cc12)C(C)(C)O
Show InChI InChI=1S/C23H28N2O4/c1-7-8-9-25-13-17(16-10-14(2)24-21(16)22(25)26)15-11-20(29-6)18(23(3,4)27)12-19(15)28-5/h7-8,10-13,24,27H,9H2,1-6H3/b8-7+
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321428
PNG
(1-[4-[6-[(E)-but-2-enyl]-2-methyl-7-oxo-1H-pyrrolo...)
Show SMILES C\C=C\Cn1cc(-c2ccc(C(=O)N3CCC(CC3)C(O)=O)c(Cl)c2)c2cc(C)[nH]c2c1=O
Show InChI InChI=1S/C25H26ClN3O4/c1-3-4-9-29-14-20(19-12-15(2)27-22(19)24(29)31)17-5-6-18(21(26)13-17)23(30)28-10-7-16(8-11-28)25(32)33/h3-6,12-14,16,27H,7-11H2,1-2H3,(H,32,33)/b4-3+
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321418
PNG
(6-allyl-4-[2,5-dimethoxy-4-(morpholine-4-carbonyl)...)
Show SMILES COc1cc(c(OC)cc1C(=O)N1CCOCC1)-c1cn(CC=C)c(=O)c2[nH]c(C)cc12
Show InChI InChI=1S/C24H27N3O5/c1-5-6-27-14-19(17-11-15(2)25-22(17)24(27)29)16-12-21(31-4)18(13-20(16)30-3)23(28)26-7-9-32-10-8-26/h5,11-14,25H,1,6-10H2,2-4H3
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321436
PNG
(4-[4-[3-(3-aminopyrazol-1-yl)azetidine-1-carbonyl]...)
Show SMILES C\C=C\Cn1cc(-c2ccc(cc2)C(=O)N2CC(C2)n2ccc(N)n2)c2cc(C)[nH]c2c1=O
Show InChI InChI=1S/C25H26N6O2/c1-3-4-10-29-15-21(20-12-16(2)27-23(20)25(29)33)17-5-7-18(8-6-17)24(32)30-13-19(14-30)31-11-9-22(26)28-31/h3-9,11-12,15,19,27H,10,13-14H2,1-2H3,(H2,26,28)/b4-3+
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321414
PNG
(6-[(E)-but-2-enyl]-4-[3-chloro-4-(4-methylpiperazi...)
Show SMILES C\C=C\Cn1cc(-c2ccc(C(=O)N3CCN(C)CC3)c(Cl)c2)c2cc(C)[nH]c2c1=O
Show InChI InChI=1S/C24H27ClN4O2/c1-4-5-8-29-15-20(19-13-16(2)26-22(19)24(29)31)17-6-7-18(21(25)14-17)23(30)28-11-9-27(3)10-12-28/h4-7,13-15,26H,8-12H2,1-3H3/b5-4+
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321409
PNG
(6-[(E)-but-2-enyl]-4-[3-chloro-4-(pyrrolidine-1-ca...)
Show SMILES C\C=C\Cn1cc(-c2ccc(C(=O)N3CCCC3)c(Cl)c2)c2cc(C)[nH]c2c1=O
Show InChI InChI=1S/C23H24ClN3O2/c1-3-4-9-27-14-19(18-12-15(2)25-21(18)23(27)29)16-7-8-17(20(24)13-16)22(28)26-10-5-6-11-26/h3-4,7-8,12-14,25H,5-6,9-11H2,1-2H3/b4-3+
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
CECR2 (aa 424-538)


(Homo sapiens (human))
BDBM321463
PNG
(6-(but-3-en-1-yl)-4-(3-(difluoromethoxy)-5-(morpho...)
Show SMILES FC(F)Oc1cc(cc(c1)-c1cn(CCC=C)c(=O)c2[nH]ccc12)C(=O)N1CCOCC1
Show InChI InChI=1S/C23H23F2N3O4/c1-2-3-6-28-14-19(18-4-5-26-20(18)22(28)30)15-11-16(13-17(12-15)32-23(24)25)21(29)27-7-9-31-10-8-27/h2,4-5,11-14,23,26H,1,3,6-10H2
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321415
PNG
(6-[(E)-but-2-enyl]-2-methyl-4-[3-methyl-4-(morphol...)
Show SMILES C\C=C\Cn1cc(-c2ccc(C(=O)N3CCOCC3)c(C)c2)c2cc(C)[nH]c2c1=O
Show InChI InChI=1S/C24H27N3O3/c1-4-5-8-27-15-21(20-14-17(3)25-22(20)24(27)29)18-6-7-19(16(2)13-18)23(28)26-9-11-30-12-10-26/h4-7,13-15,25H,8-12H2,1-3H3/b5-4+
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
CECR2 (aa 424-538)


(Homo sapiens (human))
BDBM321476
PNG
(6-but-3-enyl-4-[4-fluoro-3-(morpholine-4-carbonyl)...)
Show SMILES Cc1cc2c(cn(CCC=C)c(=O)c2[nH]1)-c1ccc(F)c(c1)C(=O)N1CCOCC1
Show InChI InChI=1S/C23H24FN3O3/c1-3-4-7-27-14-19(17-12-15(2)25-21(17)23(27)29)16-5-6-20(24)18(13-16)22(28)26-8-10-30-11-9-26/h3,5-6,12-14,25H,1,4,7-11H2,2H3
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n/an/a 11n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
CECR2 (aa 424-538)


(Homo sapiens (human))
BDBM321465
PNG
(6-but-3-enyl-4-[3-methyl-7-(morpholine-4-carbonyl)...)
Show SMILES Cn1cnc2c(cc(cc12)-c1cn(CCC=C)c(=O)c2[nH]ccc12)C(=O)N1CCOCC1
Show InChI InChI=1S/C24H25N5O3/c1-3-4-7-29-14-19(17-5-6-25-22(17)24(29)31)16-12-18(21-20(13-16)27(2)15-26-21)23(30)28-8-10-32-11-9-28/h3,5-6,12-15,25H,1,4,7-11H2,2H3
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n/an/a 11n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
CECR2 (aa 424-538)


(Homo sapiens (human))
BDBM321470
PNG
(6-but-3-enyl-4-[1-methyl-6-(morpholine-4-carbonyl)...)
Show SMILES Cn1cnc2c(cc(cc12)C(=O)N1CCOCC1)-n1cc(CCC=C)c(=O)c2[nH]ccc12
Show InChI InChI=1S/C24H25N5O3/c1-3-4-5-16-14-29(18-6-7-25-22(18)23(16)30)20-13-17(12-19-21(20)26-15-27(19)2)24(31)28-8-10-32-11-9-28/h3,6-7,12-15,25H,1,4-5,8-11H2,2H3
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n/an/a 11n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
CECR2 (aa 424-538)


(Homo sapiens (human))
BDBM321462
PNG
(6-but-3-enyl-4-[4-fluoro-3-(morpholine-4-carbonyl)...)
Show SMILES Fc1ccc(cc1C(=O)N1CCOCC1)-c1cn(CCC=C)c(=O)c2[nH]ccc12
Show InChI InChI=1S/C22H22FN3O3/c1-2-3-8-26-14-18(16-6-7-24-20(16)22(26)28)15-4-5-19(23)17(13-15)21(27)25-9-11-29-12-10-25/h2,4-7,13-14,24H,1,3,8-12H2
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n/an/a 11n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
CECR2 (aa 424-538)


(Homo sapiens (human))
BDBM321465
PNG
(6-but-3-enyl-4-[3-methyl-7-(morpholine-4-carbonyl)...)
Show SMILES Cn1cnc2c(cc(cc12)-c1cn(CCC=C)c(=O)c2[nH]ccc12)C(=O)N1CCOCC1
Show InChI InChI=1S/C24H25N5O3/c1-3-4-7-29-14-19(17-5-6-25-22(17)24(29)31)16-12-18(21-20(13-16)27(2)15-26-21)23(30)28-8-10-32-11-9-28/h3,5-6,12-15,25H,1,4,7-11H2,2H3
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n/an/a 11n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
CECR2 (aa 424-538)


(Homo sapiens (human))
BDBM321468
PNG
(6-but-3-enyl-4-[6-(morpholine-4-carbonyl)-1H-benzi...)
Show SMILES C=CCCn1cc(-c2cc(cc3[nH]cnc23)C(=O)N2CCOCC2)c2cc[nH]c2c1=O
Show InChI InChI=1S/C23H23N5O3/c1-2-3-6-28-13-18(16-4-5-24-21(16)23(28)30)17-11-15(12-19-20(17)26-14-25-19)22(29)27-7-9-31-10-8-27/h2,4-5,11-14,24H,1,3,6-10H2,(H,25,26)
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n/an/a 12n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321417
PNG
(6-allyl-4-[3-chloro-4-(morpholine-4-carbonyl)pheny...)
Show SMILES Cc1cc2c(cn(CC=C)c(=O)c2[nH]1)-c1ccc(C(=O)N2CCOCC2)c(Cl)c1
Show InChI InChI=1S/C22H22ClN3O3/c1-3-6-26-13-18(17-11-14(2)24-20(17)22(26)28)15-4-5-16(19(23)12-15)21(27)25-7-9-29-10-8-25/h3-5,11-13,24H,1,6-10H2,2H3
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n/an/a 12n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
CECR2 (aa 424-538)


(Homo sapiens (human))
BDBM321474
PNG
(6-but-3-enyl-4-[4-chloro-3-(morpholine-4-carbonyl)...)
Show SMILES Cc1cc2c(cn(CCC=C)c(=O)c2[nH]1)-c1ccc(Cl)c(c1)C(=O)N1CCOCC1
Show InChI InChI=1S/C23H24ClN3O3/c1-3-4-7-27-14-19(17-12-15(2)25-21(17)23(27)29)16-5-6-20(24)18(13-16)22(28)26-8-10-30-11-9-26/h3,5-6,12-14,25H,1,4,7-11H2,2H3
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n/an/a 12n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321407
PNG
(6-[(E)-but-2-enyl]-2-methyl-4-[4-(morpholine-4-car...)
Show SMILES C\C=C\Cn1cc(-c2ccc(cc2)C(=O)N2CCOCC2)c2cc(C)[nH]c2c1=O
Show InChI InChI=1S/C23H25N3O3/c1-3-4-9-26-15-20(19-14-16(2)24-21(19)23(26)28)17-5-7-18(8-6-17)22(27)25-10-12-29-13-11-25/h3-8,14-15,24H,9-13H2,1-2H3/b4-3+
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n/an/a 13n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321408
PNG
(6-[(E)-but-2-enyl]-2-methyl-4-[4-(pyrrolidine-1-ca...)
Show SMILES C\C=C\Cn1cc(-c2ccc(cc2)C(=O)N2CCCC2)c2cc(C)[nH]c2c1=O
Show InChI InChI=1S/C23H25N3O2/c1-3-4-11-26-15-20(19-14-16(2)24-21(19)23(26)28)17-7-9-18(10-8-17)22(27)25-12-5-6-13-25/h3-4,7-10,14-15,24H,5-6,11-13H2,1-2H3/b4-3+
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n/an/a 13n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321389
PNG
(6-[(E)-but-2-enyl]-4-[3-chloro-4-(morpholine-4-car...)
Show SMILES C\C=C\Cn1cc(-c2ccc(C(=O)N3CCOCC3)c(Cl)c2)c2cc[nH]c2c1=O
Show InChI InChI=1S/C22H22ClN3O3/c1-2-3-8-26-14-18(16-6-7-24-20(16)22(26)28)15-4-5-17(19(23)13-15)21(27)25-9-11-29-12-10-25/h2-7,13-14,24H,8-12H2,1H3/b3-2+
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n/an/a 13n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321383
PNG
(6-but-2-enyl-4-[4-(morpholine-4-carbonyl)phenyl]-1...)
Show SMILES C\C=C\Cn1cc(-c2ccc(cc2)C(=O)N2CCOCC2)c2cc[nH]c2c1=O
Show InChI InChI=1S/C22H23N3O3/c1-2-3-10-25-15-19(18-8-9-23-20(18)22(25)27)16-4-6-17(7-5-16)21(26)24-11-13-28-14-12-24/h2-9,15,23H,10-14H2,1H3/b3-2+
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n/an/a 13n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
CECR2 (aa 424-538)


(Homo sapiens (human))
BDBM321467
PNG
(6-but-3-enyl-4-[3-ethyl-7-(morpholine-4-carbonyl)b...)
Show SMILES CCn1cnc2c(cc(cc12)-c1cn(CCC=C)c(=O)c2[nH]ccc12)C(=O)N1CCOCC1
Show InChI InChI=1S/C25H27N5O3/c1-3-5-8-30-15-20(18-6-7-26-23(18)25(30)32)17-13-19(24(31)29-9-11-33-12-10-29)22-21(14-17)28(4-2)16-27-22/h3,6-7,13-16,26H,1,4-5,8-12H2,2H3
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n/an/a 14n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
CECR2 (aa 424-538)


(Homo sapiens (human))
BDBM321475
PNG
(6-but-3-enyl-4-[3-fluoro-5-(morpholine-4-carbonyl)...)
Show SMILES Cc1cc2c(cn(CCC=C)c(=O)c2[nH]1)-c1cc(F)cc(c1)C(=O)N1CCOCC1
Show InChI InChI=1S/C23H24FN3O3/c1-3-4-5-27-14-20(19-10-15(2)25-21(19)23(27)29)16-11-17(13-18(24)12-16)22(28)26-6-8-30-9-7-26/h3,10-14,25H,1,4-9H2,2H3
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n/an/a 14n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321439
PNG
(6-butyl-4-[2,5-dimethoxy-4-(morpholine-4-carbonyl)...)
Show SMILES CCCCn1cc(-c2cc(OC)c(cc2OC)C(=O)N2CCOCC2)c2cc(C)[nH]c2c1=O
Show InChI InChI=1S/C25H31N3O5/c1-5-6-7-28-15-20(18-12-16(2)26-23(18)25(28)30)17-13-22(32-4)19(14-21(17)31-3)24(29)27-8-10-33-11-9-27/h12-15,26H,5-11H2,1-4H3
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n/an/a 17n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321402
PNG
(6-[(E)-but-2-enyl]-4-[4-(1-hydroxy-1-methyl-ethyl)...)
Show SMILES C\C=C\Cn1cc(-c2ccc(cc2)C(C)(C)O)c2cc[nH]c2c1=O
Show InChI InChI=1S/C20H22N2O2/c1-4-5-12-22-13-17(16-10-11-21-18(16)19(22)23)14-6-8-15(9-7-14)20(2,3)24/h4-11,13,21,24H,12H2,1-3H3/b5-4+
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n/an/a 17n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
CECR2 (aa 424-538)


(Homo sapiens (human))
BDBM321458
PNG
(6-but-3-enyl-4-[3,4-difluoro-5-(morpholine-4-carbo...)
Show SMILES Fc1cc(cc(C(=O)N2CCOCC2)c1F)-c1cn(CCC=C)c(=O)c2[nH]ccc12
Show InChI InChI=1S/C22H21F2N3O3/c1-2-3-6-27-13-17(15-4-5-25-20(15)22(27)29)14-11-16(19(24)18(23)12-14)21(28)26-7-9-30-10-8-26/h2,4-5,11-13,25H,1,3,6-10H2
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n/an/a 17n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
CECR2 (aa 424-538)


(Homo sapiens (human))
BDBM321459
PNG
(6-but-3-enyl-4-[3-fluoro-5-(3-methylmorpholine-4-c...)
Show SMILES CC1COCCN1C(=O)c1cc(F)cc(c1)-c1cn(CCC=C)c(=O)c2[nH]ccc12
Show InChI InChI=1S/C23H24FN3O3/c1-3-4-7-26-13-20(19-5-6-25-21(19)23(26)29)16-10-17(12-18(24)11-16)22(28)27-8-9-30-14-15(27)2/h3,5-6,10-13,15,25H,1,4,7-9,14H2,2H3
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n/an/a 19n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
CECR2 (aa 424-538)


(Homo sapiens (human))
BDBM321469
PNG
(4-(6-(but-3-en-1-yl)-7-oxo-6,7-dihydro-1H-pyrrolo[...)
Show SMILES CN(C)C(=O)c1cc(-c2cn(CCC=C)c(=O)c3[nH]ccc23)c2nc[nH]c2c1
Show InChI InChI=1S/C21H21N5O2/c1-4-5-8-26-11-16(14-6-7-22-19(14)21(26)28)15-9-13(20(27)25(2)3)10-17-18(15)24-12-23-17/h4,6-7,9-12,22H,1,5,8H2,2-3H3,(H,23,24)
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n/an/a 20n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321400
PNG
(6-[(E)-but-2-enyl]-4-[4-(1-hydroxy-1-methyl-ethyl)...)
Show SMILES COc1cc(ccc1-n1cc(C\C=C\C)c(=O)c2[nH]ccc12)C(C)(C)O
Show InChI InChI=1S/C21H24N2O3/c1-5-6-7-14-13-23(17-10-11-22-19(17)20(14)24)16-9-8-15(21(2,3)25)12-18(16)26-4/h5-6,8-13,22,25H,7H2,1-4H3/b6-5+
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n/an/a 20n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
CECR2 (aa 424-538)


(Homo sapiens (human))
BDBM321461
PNG
(6-but-3-enyl-4-[3-fluoro-5-(morpholine-4-carbonyl)...)
Show SMILES Fc1cc(cc(c1)-c1cn(CCC=C)c(=O)c2[nH]ccc12)C(=O)N1CCOCC1
Show InChI InChI=1S/C22H22FN3O3/c1-2-3-6-26-14-19(18-4-5-24-20(18)22(26)28)15-11-16(13-17(23)12-15)21(27)25-7-9-29-10-8-25/h2,4-5,11-14,24H,1,3,6-10H2
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n/an/a 20n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
CECR2 (aa 424-538)


(Homo sapiens (human))
BDBM321460
PNG
(3-(6-but-3-enyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-y...)
Show SMILES C=CCCn1cc(-c2cc(cc(c2)C(=O)N2CCOCC2)C#N)c2cc[nH]c2c1=O
Show InChI InChI=1S/C23H22N4O3/c1-2-3-6-27-15-20(19-4-5-25-21(19)23(27)29)17-11-16(14-24)12-18(13-17)22(28)26-7-9-30-10-8-26/h2,4-5,11-13,15,25H,1,3,6-10H2
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n/an/a 21n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
CECR2 (aa 424-538)


(Homo sapiens (human))
BDBM321464
PNG
(6-but-3-enyl-4-[7-(morpholine-4-carbonyl)-3H-benzi...)
Show SMILES C=CCCn1cc(-c2cc(C(=O)N3CCOCC3)c3nc[nH]c3c2)c2cc[nH]c2c1=O
Show InChI InChI=1S/C23H23N5O3/c1-2-3-6-28-13-18(16-4-5-24-21(16)23(28)30)15-11-17(20-19(12-15)25-14-26-20)22(29)27-7-9-31-10-8-27/h2,4-5,11-14,24H,1,3,6-10H2,(H,25,26)
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n/an/a 21n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321381
PNG
(N-[4-(6-but-2-enyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-...)
Show SMILES C\C=C\Cn1cc(-c2ccc(NS(C)(=O)=O)cc2)c2cc[nH]c2c1=O
Show InChI InChI=1S/C18H19N3O3S/c1-3-4-11-21-12-16(15-9-10-19-17(15)18(21)22)13-5-7-14(8-6-13)20-25(2,23)24/h3-10,12,19-20H,11H2,1-2H3/b4-3+
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n/an/a 22n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321420
PNG
(6-[(E)-but-2-enyl]-4-[4-chloro-5-(morpholine-4-car...)
Show SMILES C\C=C\Cn1cc(-c2cc(Cl)c(cn2)C(=O)N2CCOCC2)c2cc(C)[nH]c2c1=O
Show InChI InChI=1S/C22H23ClN4O3/c1-3-4-5-27-13-17(15-10-14(2)25-20(15)22(27)29)19-11-18(23)16(12-24-19)21(28)26-6-8-30-9-7-26/h3-4,10-13,25H,5-9H2,1-2H3/b4-3+
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n/an/a 22n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321396
PNG
(3-[6-[(E)-but-2-enyl]-7-oxo-1H-pyrrolo[2,3-c]pyrid...)
Show SMILES COc1ccc(cc1-c1cn(C\C=C\C)c(=O)c2[nH]ccc12)C(=O)NCCN(C)C
Show InChI InChI=1S/C23H28N4O3/c1-5-6-12-27-15-19(17-9-10-24-21(17)23(27)29)18-14-16(7-8-20(18)30-4)22(28)25-11-13-26(2)3/h5-10,14-15,24H,11-13H2,1-4H3,(H,25,28)/b6-5+
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n/an/a 23n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321398
PNG
(3-[6-[(E)-but-2-enyl]-7-oxo-1H-pyrrolo[2,3-c]pyrid...)
Show SMILES CCCNC(=O)c1ccc(OC)c(c1)-c1cn(C\C=C\C)c(=O)c2[nH]ccc12
Show InChI InChI=1S/C22H25N3O3/c1-4-6-12-25-14-18(16-9-11-23-20(16)22(25)27)17-13-15(7-8-19(17)28-3)21(26)24-10-5-2/h4,6-9,11,13-14,23H,5,10,12H2,1-3H3,(H,24,26)/b6-4+
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n/an/a 27n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321392
PNG
(3-[6-[(E)-but-2-enyl]-7-oxo-1H-pyrrolo[2,3-c]pyrid...)
Show SMILES CCNC(=O)c1ccc(OC)c(c1)-c1cn(C\C=C\C)c(=O)c2[nH]ccc12
Show InChI InChI=1S/C21H23N3O3/c1-4-6-11-24-13-17(15-9-10-23-19(15)21(24)26)16-12-14(20(25)22-5-2)7-8-18(16)27-3/h4,6-10,12-13,23H,5,11H2,1-3H3,(H,22,25)/b6-4+
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n/an/a 28n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321395
PNG
(3-[6-[(E)-but-2-enyl]-7-oxo-1H-pyrrolo[2,3-c]pyrid...)
Show SMILES COc1ccc(cc1-c1cn(C\C=C\C)c(=O)c2[nH]ccc12)C(=O)NCC(C)C
Show InChI InChI=1S/C23H27N3O3/c1-5-6-11-26-14-19(17-9-10-24-21(17)23(26)28)18-12-16(7-8-20(18)29-4)22(27)25-13-15(2)3/h5-10,12,14-15,24H,11,13H2,1-4H3,(H,25,27)/b6-5+
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n/an/a 28n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321377
PNG
(4-(6-but-2-enyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-y...)
Show SMILES CNC(=O)c1ccc(cc1)-c1cn(C\C=C\C)c(=O)c2[nH]ccc12
Show InChI InChI=1S/C19H19N3O2/c1-3-4-11-22-12-16(15-9-10-21-17(15)19(22)24)13-5-7-14(8-6-13)18(23)20-2/h3-10,12,21H,11H2,1-2H3,(H,20,23)/b4-3+
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n/an/a 29n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321413
PNG
(6-[(E)-but-2-enyl]-4-[5-chloro-6-(morpholine-4-car...)
Show SMILES C\C=C\Cn1cc(-c2cnc(C(=O)N3CCOCC3)c(Cl)c2)c2cc(C)[nH]c2c1=O
Show InChI InChI=1S/C22H23ClN4O3/c1-3-4-5-27-13-17(16-10-14(2)25-19(16)21(27)28)15-11-18(23)20(24-12-15)22(29)26-6-8-30-9-7-26/h3-4,10-13,25H,5-9H2,1-2H3/b4-3+
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n/an/a 32n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321410
PNG
(6-[(E)-but-2-enyl]-4-[2,3-difluoro-4-(morpholine-4...)
Show SMILES C\C=C\Cn1cc(-c2ccc(C(=O)N3CCOCC3)c(F)c2F)c2cc(C)[nH]c2c1=O
Show InChI InChI=1S/C23H23F2N3O3/c1-3-4-7-28-13-18(17-12-14(2)26-21(17)23(28)30)15-5-6-16(20(25)19(15)24)22(29)27-8-10-31-11-9-27/h3-6,12-13,26H,7-11H2,1-2H3/b4-3+
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n/an/a 34n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321393
PNG
(3-[6-[(E)-but-2-enyl]-7-oxo-1H-pyrrolo[2,3-c]pyrid...)
Show SMILES CNC(=O)c1ccc(OC)c(c1)-c1cn(C\C=C\C)c(=O)c2[nH]ccc12
Show InChI InChI=1S/C20H21N3O3/c1-4-5-10-23-12-16(14-8-9-22-18(14)20(23)25)15-11-13(19(24)21-2)6-7-17(15)26-3/h4-9,11-12,22H,10H2,1-3H3,(H,21,24)/b5-4+
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n/an/a 35n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321397
PNG
(3-[6-[(E)-but-2-enyl]-7-oxo-1H-pyrrolo[2,3-c]pyrid...)
Show SMILES COc1ccc(cc1-c1cn(C\C=C\C)c(=O)c2[nH]ccc12)C(=O)NCCO
Show InChI InChI=1S/C21H23N3O4/c1-3-4-10-24-13-17(15-7-8-22-19(15)21(24)27)16-12-14(5-6-18(16)28-2)20(26)23-9-11-25/h3-8,12-13,22,25H,9-11H2,1-2H3,(H,23,26)/b4-3+
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n/an/a 35n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321378
PNG
(6-but-2-enyl-4-[3-(pyrrolidine-1-carbonyl)phenyl]-...)
Show SMILES C\C=C\Cn1cc(-c2cccc(c2)C(=O)N2CCCC2)c2cc[nH]c2c1=O
Show InChI InChI=1S/C22H23N3O2/c1-2-3-11-25-15-19(18-9-10-23-20(18)22(25)27)16-7-6-8-17(14-16)21(26)24-12-4-5-13-24/h2-3,6-10,14-15,23H,4-5,11-13H2,1H3/b3-2+
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n/an/a 39n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321426
PNG
(6-but-2-enyl-4-[3-methoxy-5-(4-methylpiperazine-1-...)
Show SMILES COc1cc(cnc1-c1cn(C\C=C\C)c(=O)c2[nH]c(C)cc12)C(=O)N1CCN(C)CC1
Show InChI InChI=1S/C24H29N5O3/c1-5-6-7-29-15-19(18-12-16(2)26-22(18)24(29)31)21-20(32-4)13-17(14-25-21)23(30)28-10-8-27(3)9-11-28/h5-6,12-15,26H,7-11H2,1-4H3/b6-5+
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n/an/a 39n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321394
PNG
(6-[(E)-but-2-enyl]-4-[2-methoxy-5-(pyrrolidine-1-c...)
Show SMILES COc1ccc(cc1-c1cn(C\C=C\C)c(=O)c2[nH]ccc12)C(=O)N1CCCC1
Show InChI InChI=1S/C23H25N3O3/c1-3-4-11-26-15-19(17-9-10-24-21(17)23(26)28)18-14-16(7-8-20(18)29-2)22(27)25-12-5-6-13-25/h3-4,7-10,14-15,24H,5-6,11-13H2,1-2H3/b4-3+
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n/an/a 39n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321403
PNG
(6-butyl-4-(4-(2-hydroxypropan-2-yl)phenyl)-1H-pyrr...)
Show SMILES CCCCn1cc(-c2ccc(cc2)C(C)(C)O)c2cc[nH]c2c1=O
Show InChI InChI=1S/C20H24N2O2/c1-4-5-12-22-13-17(16-10-11-21-18(16)19(22)23)14-6-8-15(9-7-14)20(2,3)24/h6-11,13,21,24H,4-5,12H2,1-3H3
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n/an/a 43n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321419
PNG
(6-[(E)-but-2-enyl]-4-[3-methoxy-5-(morpholine-4-ca...)
Show SMILES COc1cc(cnc1-c1cn(C\C=C\C)c(=O)c2[nH]c(C)cc12)C(=O)N1CCOCC1
Show InChI InChI=1S/C23H26N4O4/c1-4-5-6-27-14-18(17-11-15(2)25-21(17)23(27)29)20-19(30-3)12-16(13-24-20)22(28)26-7-9-31-10-8-26/h4-5,11-14,25H,6-10H2,1-3H3/b5-4+
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n/an/a 46n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321388
PNG
(3-(6-butyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl)-4-...)
Show SMILES CCCCn1cc(-c2cc(ccc2OC)C#N)c2cc[nH]c2c1=O
Show InChI InChI=1S/C19H19N3O2/c1-3-4-9-22-12-16(14-7-8-21-18(14)19(22)23)15-10-13(11-20)5-6-17(15)24-2/h5-8,10,12,21H,3-4,9H2,1-2H3
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n/an/a 46n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321390
PNG
(6-[(E)-but-2-enyl]-4-[3-chloro-4-(pyrrolidine-1-ca...)
Show SMILES C\C=C\Cn1cc(-c2ccc(C(=O)N3CCCC3)c(Cl)c2)c2cc[nH]c2c1=O
Show InChI InChI=1S/C22H22ClN3O2/c1-2-3-10-26-14-18(16-8-9-24-20(16)22(26)28)15-6-7-17(19(23)13-15)21(27)25-11-4-5-12-25/h2-3,6-9,13-14,24H,4-5,10-12H2,1H3/b3-2+
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n/an/a 46n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321391
PNG
(3-[6-[(E)-but-2-enyl]-7-oxo-1H-pyrrolo[2,3-c]pyrid...)
Show SMILES COc1ccc(cc1-c1cn(C\C=C\C)c(=O)c2[nH]ccc12)C(=O)N(C)C
Show InChI InChI=1S/C21H23N3O3/c1-5-6-11-24-13-17(15-9-10-22-19(15)21(24)26)16-12-14(20(25)23(2)3)7-8-18(16)27-4/h5-10,12-13,22H,11H2,1-4H3/b6-5+
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n/an/a 56n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321399
PNG
(4-[5-(6-acetyl-2,6-diazaspiro[3.3]heptane-2-carbon...)
Show SMILES CCCCn1cc(-c2cc(ccc2OC)C(=O)N2CC3(CN(C3)C(C)=O)C2)c2cc[nH]c2c1=O
Show InChI InChI=1S/C26H30N4O4/c1-4-5-10-28-12-21(19-8-9-27-23(19)25(28)33)20-11-18(6-7-22(20)34-3)24(32)30-15-26(16-30)13-29(14-26)17(2)31/h6-9,11-12,27H,4-5,10,13-16H2,1-3H3
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n/an/a 65n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321405
PNG
(3-(6-butyl-2-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridin...)
Show SMILES CCCCn1cc(-c2cc(ccc2OC)C(=O)N(C)C)c2cc(C)[nH]c2c1=O
Show InChI InChI=1S/C22H27N3O3/c1-6-7-10-25-13-18(17-11-14(2)23-20(17)22(25)27)16-12-15(21(26)24(3)4)8-9-19(16)28-5/h8-9,11-13,23H,6-7,10H2,1-5H3
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n/an/a 66n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321427
PNG
(6-[(E)-but-2-enyl]-4-[6-chloro-5-(morpholine-4-car...)
Show SMILES C\C=C\Cn1cc(-c2ccc(C(=O)N3CCOCC3)c(Cl)n2)c2cc(C)[nH]c2c1=O
Show InChI InChI=1S/C22H23ClN4O3/c1-3-4-7-27-13-17(16-12-14(2)24-19(16)22(27)29)18-6-5-15(20(23)25-18)21(28)26-8-10-30-11-9-26/h3-6,12-13,24H,7-11H2,1-2H3/b4-3+
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n/an/a 69n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321401
PNG
(6-butyl-4-[4-(1-hydroxy-1-methyl-ethyl)-2-methoxy-...)
Show SMILES CCCCn1cc(-c2ccc(cc2OC)C(C)(C)O)c2cc[nH]c2c1=O
Show InChI InChI=1S/C21H26N2O3/c1-5-6-11-23-13-17(16-9-10-22-19(16)20(23)24)15-8-7-14(21(2,3)25)12-18(15)26-4/h7-10,12-13,22,25H,5-6,11H2,1-4H3
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n/an/a 73n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321387
PNG
(3-[6-[(E)-but-2-enyl]-7-oxo-1H-pyrrolo[2,3-c]pyrid...)
Show SMILES C\C=C\Cn1cc(-c2cccc(C(=O)N(C)C)c2F)c2cc[nH]c2c1=O
Show InChI InChI=1S/C20H20FN3O2/c1-4-5-11-24-12-16(14-9-10-22-18(14)20(24)26)13-7-6-8-15(17(13)21)19(25)23(2)3/h4-10,12,22H,11H2,1-3H3/b5-4+
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n/an/a 82n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321421
PNG
(6-[(E)-but-2-enyl]-2-methyl-4-[2-(morpholine-4-car...)
Show SMILES C\C=C\Cn1cc(-c2cnc(nc2)C(=O)N2CCOCC2)c2cc(C)[nH]c2c1=O
Show InChI InChI=1S/C21H23N5O3/c1-3-4-5-26-13-17(16-10-14(2)24-18(16)20(26)27)15-11-22-19(23-12-15)21(28)25-6-8-29-9-7-25/h3-4,10-13,24H,5-9H2,1-2H3/b4-3+
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n/an/a 83n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321376
PNG
(3-[6-[(E)-but-2-enyl]-7-oxo-1H-pyrrolo[2,3-c]pyrid...)
Show SMILES C\C=C\Cn1cc(-c2cc(F)cc(c2)C(=O)N(C)C)c2cc[nH]c2c1=O
Show InChI InChI=1S/C20H20FN3O2/c1-4-5-8-24-12-17(16-6-7-22-18(16)20(24)26)13-9-14(11-15(21)10-13)19(25)23(2)3/h4-7,9-12,22H,8H2,1-3H3/b5-4+
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n/an/a 94n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
CECR2 (aa 424-538)


(Homo sapiens (human))
BDBM321452
PNG
(6-but-3-enyl-4-[3-(5-methyl-1,3,4-oxadiazol-2-yl)p...)
Show SMILES Cc1nnc(o1)-c1cccc(c1)-c1cn(CCC=C)c(=O)c2[nH]ccc12
Show InChI InChI=1S/C20H18N4O2/c1-3-4-10-24-12-17(16-8-9-21-18(16)20(24)25)14-6-5-7-15(11-14)19-23-22-13(2)26-19/h3,5-9,11-12,21H,1,4,10H2,2H3
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n/an/a 95n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321423
PNG
(6-[(E)-but-2-enyl]-4-[4-(1-hydroxy-1-methyl-ethyl)...)
Show SMILES COc1cc(ccc1-c1cn(C\C=C\C)c(=O)c2[nH]c(C)cc12)C(C)(C)O
Show InChI InChI=1S/C22H26N2O3/c1-6-7-10-24-13-18(17-11-14(2)23-20(17)21(24)25)16-9-8-15(22(3,4)26)12-19(16)27-5/h6-9,11-13,23,26H,10H2,1-5H3/b7-6+
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n/an/a 100n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
CECR2 (aa 424-538)


(Homo sapiens (human))
BDBM321448
PNG
(3-(6-but-3-enyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-y...)
Show SMILES CN(C)C(=O)c1cccc(c1)-c1cn(CCC=C)c(=O)c2[nH]ccc12
Show InChI InChI=1S/C20H21N3O2/c1-4-5-11-23-13-17(16-9-10-21-18(16)20(23)25)14-7-6-8-15(12-14)19(24)22(2)3/h4,6-10,12-13,21H,1,5,11H2,2-3H3
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n/an/a 110n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321385
PNG
(3-[6-[(E)-but-2-enyl]-7-oxo-1H-pyrrolo[2,3-c]pyrid...)
Show SMILES C\C=C\Cn1cc(-c2cc(ccc2F)C(=O)N(C)C)c2cc[nH]c2c1=O
Show InChI InChI=1S/C20H20FN3O2/c1-4-5-10-24-12-16(14-8-9-22-18(14)20(24)26)15-11-13(6-7-17(15)21)19(25)23(2)3/h4-9,11-12,22H,10H2,1-3H3/b5-4+
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n/an/a 130n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321441
PNG
(6-butyl-4-[3-methoxy-5-(4-methylpiperazine-1-carbo...)
Show SMILES CCCCn1cc(-c2ncc(cc2OC)C(=O)N2CCN(C)CC2)c2cc(C)[nH]c2c1=O
Show InChI InChI=1S/C24H31N5O3/c1-5-6-7-29-15-19(18-12-16(2)26-22(18)24(29)31)21-20(32-4)13-17(14-25-21)23(30)28-10-8-27(3)9-11-28/h12-15,26H,5-11H2,1-4H3
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n/an/a 180n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321442
PNG
(6-butyl-4-[3-methoxy-5-(morpholine-4-carbonyl)-2-p...)
Show SMILES CCCCn1cc(-c2ncc(cc2OC)C(=O)N2CCOCC2)c2cc(C)[nH]c2c1=O
Show InChI InChI=1S/C23H28N4O4/c1-4-5-6-27-14-18(17-11-15(2)25-21(17)23(27)29)20-19(30-3)12-16(13-24-20)22(28)26-7-9-31-10-8-26/h11-14,25H,4-10H2,1-3H3
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n/an/a 210n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321404
PNG
(6-(2-cyclopropylethyl)-4-[4-(1-hydroxy-1-methyl-et...)
Show SMILES CC(C)(O)c1ccc(cc1)-c1cn(CCC2CC2)c(=O)c2[nH]ccc12
Show InChI InChI=1S/C21H24N2O2/c1-21(2,25)16-7-5-15(6-8-16)18-13-23(12-10-14-3-4-14)20(24)19-17(18)9-11-22-19/h5-9,11,13-14,22,25H,3-4,10,12H2,1-2H3
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n/an/a 280n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321406
PNG
(3-[6-(2-cyclopropylethyl)-2-methyl-7-oxo-1H-pyrrol...)
Show SMILES COc1ccc(cc1-c1cn(CCC2CC2)c(=O)c2[nH]c(C)cc12)C(=O)N(C)C
Show InChI InChI=1S/C23H27N3O3/c1-14-11-18-19(13-26(10-9-15-5-6-15)23(28)21(18)24-14)17-12-16(22(27)25(2)3)7-8-20(17)29-4/h7-8,11-13,15,24H,5-6,9-10H2,1-4H3
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n/an/a 300n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD4 BD1 (aa 42-168)


(Homo sapiens (human))
BDBM321365
PNG
(3-[6-[(E)-but-2-enyl]-7-oxo-1H-pyrrolo[2,3-c]pyrid...)
Show SMILES COc1ccc(cc1-c1cn(C\C=C\C)c(=O)c2[nH]ccc12)C(=O)NCC(F)F
Show InChI InChI=1S/C21H21F2N3O3/c1-3-4-9-26-12-16(14-7-8-24-19(14)21(26)28)15-10-13(5-6-17(15)29-2)20(27)25-11-18(22)23/h3-8,10,12,18,24H,9,11H2,1-2H3,(H,25,27)/b4-3+
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n/an/a 320n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to homogeneity. BRD4 binding and inhibition was assessed by monitoring the...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321371
PNG
(3-(6-isopentyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl...)
Show SMILES CC(C)CCn1cc(-c2cccc(c2)C(=O)N(C)C)c2cc[nH]c2c1=O
Show InChI InChI=1S/C21H25N3O2/c1-14(2)9-11-24-13-18(17-8-10-22-19(17)21(24)26)15-6-5-7-16(12-15)20(25)23(3)4/h5-8,10,12-14,22H,9,11H2,1-4H3
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n/an/a 320n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD4 BD1 (aa 42-168)


(Homo sapiens (human))
BDBM321357
PNG
(3-(6-but-2-enyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-y...)
Show SMILES C\C=C\Cn1cc(-c2cccc(c2)C(=O)N(C)C)c2cc[nH]c2c1=O
Show InChI InChI=1S/C20H21N3O2/c1-4-5-11-23-13-17(16-9-10-21-18(16)20(23)25)14-7-6-8-15(12-14)19(24)22(2)3/h4-10,12-13,21H,11H2,1-3H3/b5-4+
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n/an/a 330n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to homogeneity. BRD4 binding and inhibition was assessed by monitoring the...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (human))
BDBM321443
PNG
(3-(6-allyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl)-N,...)
Show SMILES CN(C)C(=O)c1cccc(c1)-c1cn(CC=C)c(=O)c2[nH]ccc12
Show InChI InChI=1S/C19H19N3O2/c1-4-10-22-12-16(15-8-9-20-17(15)19(22)24)13-6-5-7-14(11-13)18(23)21(2)3/h4-9,11-12,20H,1,10H2,2-3H3
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n/an/a 390n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CECR2424-538 was cloned, expressed, and purified to homogeneity. CECR2 binding and inhibition was assessed by monitoring the ...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
CECR2 (aa 424-538)


(Homo sapiens (human))
BDBM321473
PNG
(3-(6-(2-cyclopropylethyl)-2-methyl-7-oxo-6,7-dihyd...)
Show SMILES CN(C)C(=O)c1cccc(c1)-c1cn(CCC2CC2)c(=O)c2[nH]c(C)cc12
Show InChI InChI=1S/C22H25N3O2/c1-14-11-18-19(16-5-4-6-17(12-16)21(26)24(2)3)13-25(10-9-15-7-8-15)22(27)20(18)23-14/h4-6,11-13,15,23H,7-10H2,1-3H3
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n/an/a 480n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321379
PNG
(3-(6-but-2-enyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-y...)
Show SMILES C\C=C\Cn1cc(-c2cccc(c2)C(N)=O)c2cc[nH]c2c1=O
Show InChI InChI=1S/C18H17N3O2/c1-2-3-9-21-11-15(14-7-8-20-16(14)18(21)23)12-5-4-6-13(10-12)17(19)22/h2-8,10-11,20H,9H2,1H3,(H2,19,22)/b3-2+
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n/an/a 510n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD4 BD1 (aa 42-168)


(Homo sapiens (human))
BDBM321355
PNG
(4-(6-but-2-enyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-y...)
Show SMILES C\C=C\Cn1cc(-c2ccc(cc2)C(=O)NC2CC2)c2cc[nH]c2c1=O
Show InChI InChI=1S/C21H21N3O2/c1-2-3-12-24-13-18(17-10-11-22-19(17)21(24)26)14-4-6-15(7-5-14)20(25)23-16-8-9-16/h2-7,10-11,13,16,22H,8-9,12H2,1H3,(H,23,25)/b3-2+
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n/an/a 510n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to homogeneity. BRD4 binding and inhibition was assessed by monitoring the...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
CECR2 (aa 424-538)


(Homo sapiens (human))
BDBM321453
PNG
(3-(6-but-2-enyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-y...)
Show SMILES CNC(=O)c1cccc(c1)-c1cn(C\C=C\C)c(=O)c2[nH]ccc12
Show InChI InChI=1S/C19H19N3O2/c1-3-4-10-22-12-16(15-8-9-21-17(15)19(22)24)13-6-5-7-14(11-13)18(23)20-2/h3-9,11-12,21H,10H2,1-2H3,(H,20,23)/b4-3+
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n/an/a 640n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD4 BD1 (aa 42-168)


(Homo sapiens (human))
BDBM321358
PNG
(3-(6-but-2-enyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-y...)
Show SMILES C\C=C\Cn1cc(-c2cccc(c2)C(=O)NC(C)C)c2cc[nH]c2c1=O
Show InChI InChI=1S/C21H23N3O2/c1-4-5-11-24-13-18(17-9-10-22-19(17)21(24)26)15-7-6-8-16(12-15)20(25)23-14(2)3/h4-10,12-14,22H,11H2,1-3H3,(H,23,25)/b5-4+
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n/an/a 720n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to homogeneity. BRD4 binding and inhibition was assessed by monitoring the...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD4 BD1 (aa 42-168)


(Homo sapiens (human))
BDBM321354
PNG
(3-(6-but-2-enyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-y...)
Show SMILES C\C=C\Cn1cc(-c2cccc(c2)C(=O)NC2CC2)c2cc[nH]c2c1=O
Show InChI InChI=1S/C21H21N3O2/c1-2-3-11-24-13-18(17-9-10-22-19(17)21(24)26)14-5-4-6-15(12-14)20(25)23-16-7-8-16/h2-6,9-10,12-13,16,22H,7-8,11H2,1H3,(H,23,25)/b3-2+
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n/an/a 830n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to homogeneity. BRD4 binding and inhibition was assessed by monitoring the...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD4 BD1 (aa 42-168)


(Homo sapiens (human))
BDBM321351
PNG
(4-[6-[(E)-but-2-enyl]-7-oxo-1H-pyrrolo[2,3-c]pyrid...)
Show SMILES C\C=C\Cn1cc(-c2ccc(C(N)=O)c(F)c2)c2cc[nH]c2c1=O
Show InChI InChI=1S/C18H16FN3O2/c1-2-3-8-22-10-14(12-6-7-21-16(12)18(22)24)11-4-5-13(17(20)23)15(19)9-11/h2-7,9-10,21H,8H2,1H3,(H2,20,23)/b3-2+
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n/an/a 890n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to homogeneity. BRD4 binding and inhibition was assessed by monitoring the...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
CECR2 (aa 424-538)


(Homo sapiens (human))
BDBM321472
PNG
(4-[5-(6-acetyl-2,6-diazaspiro[3.3]heptane-2-carbon...)
Show SMILES COc1ccc(cc1-c1cn(C\C=C\C)c(=O)c2[nH]ccc12)C(=O)N1CC2(CN(C2)C(C)=O)C1
Show InChI InChI=1S/C26H28N4O4/c1-4-5-10-28-12-21(19-8-9-27-23(19)25(28)33)20-11-18(6-7-22(20)34-3)24(32)30-15-26(16-30)13-29(14-26)17(2)31/h4-9,11-12,27H,10,13-16H2,1-3H3/b5-4+
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n/an/a 900n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD4 BD1 (aa 42-168)


(Homo sapiens (human))
BDBM321363
PNG
(3-[6-[(E)-but-2-enyl]-7-oxo-1H-pyrrolo[2,3-c]pyrid...)
Show SMILES COc1ccc(cc1-c1cn(C\C=C\C)c(=O)c2[nH]ccc12)C(=O)NC1CC1
Show InChI InChI=1S/C22H23N3O3/c1-3-4-11-25-13-18(16-9-10-23-20(16)22(25)27)17-12-14(5-8-19(17)28-2)21(26)24-15-6-7-15/h3-5,8-10,12-13,15,23H,6-7,11H2,1-2H3,(H,24,26)/b4-3+
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n/an/a 980n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to homogeneity. BRD4 binding and inhibition was assessed by monitoring the...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD4 BD1 (aa 42-168)


(Homo sapiens (human))
BDBM321360
PNG
(3-[6-[(E)-but-2-enyl]-7-oxo-1H-pyrrolo[2,3-c]pyrid...)
Show SMILES C\C=C\Cn1cc(-c2cccc(C(N)=O)c2F)c2cc[nH]c2c1=O
Show InChI InChI=1S/C18H16FN3O2/c1-2-3-9-22-10-14(12-7-8-21-16(12)18(22)24)11-5-4-6-13(15(11)19)17(20)23/h2-8,10,21H,9H2,1H3,(H2,20,23)/b3-2+
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n/an/a 1.20E+3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to homogeneity. BRD4 binding and inhibition was assessed by monitoring the...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD4 BD1 (aa 42-168)


(Homo sapiens (human))
BDBM321367
PNG
(3-[6-[(E)-but-2-enyl]-7-oxo-1H-pyrrolo[2,3-c]pyrid...)
Show SMILES COc1ccc(cc1-c1cn(C\C=C\C)c(=O)c2[nH]ccc12)C(=O)NCC1CC1
Show InChI InChI=1S/C23H25N3O3/c1-3-4-11-26-14-19(17-9-10-24-21(17)23(26)28)18-12-16(7-8-20(18)29-2)22(27)25-13-15-5-6-15/h3-4,7-10,12,14-15,24H,5-6,11,13H2,1-2H3,(H,25,27)/b4-3+
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n/an/a 1.20E+3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to homogeneity. BRD4 binding and inhibition was assessed by monitoring the...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD4 BD1 (aa 42-168)


(Homo sapiens (human))
BDBM321366
PNG
(3-[6-[(E)-but-2-enyl]-7-oxo-1H-pyrrolo[2,3-c]pyrid...)
Show SMILES COc1ccc(cc1-c1cn(C\C=C\C)c(=O)c2[nH]ccc12)C(=O)NC1CCC1
Show InChI InChI=1S/C23H25N3O3/c1-3-4-12-26-14-19(17-10-11-24-21(17)23(26)28)18-13-15(8-9-20(18)29-2)22(27)25-16-6-5-7-16/h3-4,8-11,13-14,16,24H,5-7,12H2,1-2H3,(H,25,27)/b4-3+
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n/an/a 1.30E+3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to homogeneity. BRD4 binding and inhibition was assessed by monitoring the...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD4 BD1 (aa 42-168)


(Homo sapiens (human))
BDBM321359
PNG
(3-(6-but-2-enyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-y...)
Show SMILES COc1ccc(cc1-c1cn(C\C=C\C)c(=O)c2[nH]ccc12)C#N
Show InChI InChI=1S/C19H17N3O2/c1-3-4-9-22-12-16(14-7-8-21-18(14)19(22)23)15-10-13(11-20)5-6-17(15)24-2/h3-8,10,12,21H,9H2,1-2H3/b4-3+
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n/an/a 1.40E+3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to homogeneity. BRD4 binding and inhibition was assessed by monitoring the...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD4 BD1 (aa 42-168)


(Homo sapiens (human))
BDBM321356
PNG
(6-but-2-enyl-4-(4-isopropylphenyl)-1H-pyrrolo[2,3-...)
Show SMILES C\C=C\Cn1cc(-c2ccc(cc2)C(C)C)c2cc[nH]c2c1=O
Show InChI InChI=1S/C20H22N2O/c1-4-5-12-22-13-18(17-10-11-21-19(17)20(22)23)16-8-6-15(7-9-16)14(2)3/h4-11,13-14,21H,12H2,1-3H3/b5-4+
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n/an/a 1.60E+3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to homogeneity. BRD4 binding and inhibition was assessed by monitoring the...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
CECR2 (aa 424-538)


(Homo sapiens (human))
BDBM321456
PNG
(4-[6-[(E)-but-2-enyl]-7-oxo-1H-pyrrolo[2,3-c]pyrid...)
Show SMILES C\C=C\Cn1cc(-c2ccc(C(N)=O)c(Cl)c2)c2cc[nH]c2c1=O
Show InChI InChI=1S/C18H16ClN3O2/c1-2-3-8-22-10-14(12-6-7-21-16(12)18(22)24)11-4-5-13(17(20)23)15(19)9-11/h2-7,9-10,21H,8H2,1H3,(H2,20,23)/b3-2+
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n/an/a 1.60E+3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD4 BD1 (aa 42-168)


(Homo sapiens (human))
BDBM321364
PNG
(3-[6-[(E)-but-2-enyl]-7-oxo-1H-pyrrolo[2,3-c]pyrid...)
Show SMILES COc1ccc(cc1-c1cn(C\C=C\C)c(=O)c2[nH]ccc12)C(=O)NC1CCOC1
Show InChI InChI=1S/C23H25N3O4/c1-3-4-10-26-13-19(17-7-9-24-21(17)23(26)28)18-12-15(5-6-20(18)29-2)22(27)25-16-8-11-30-14-16/h3-7,9,12-13,16,24H,8,10-11,14H2,1-2H3,(H,25,27)/b4-3+
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n/an/a 1.60E+3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to homogeneity. BRD4 binding and inhibition was assessed by monitoring the...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD4 BD1 (aa 42-168)


(Homo sapiens (human))
BDBM321361
PNG
(3-[6-[(E)-but-2-enyl]-7-oxo-1H-pyrrolo[2,3-c]pyrid...)
Show SMILES C\C=C\Cn1cc(-c2cc(ccc2F)C(N)=O)c2cc[nH]c2c1=O
Show InChI InChI=1S/C18H16FN3O2/c1-2-3-8-22-10-14(12-6-7-21-16(12)18(22)24)13-9-11(17(20)23)4-5-15(13)19/h2-7,9-10,21H,8H2,1H3,(H2,20,23)/b3-2+
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n/an/a 1.80E+3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to homogeneity. BRD4 binding and inhibition was assessed by monitoring the...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
CECR2 (aa 424-538)


(Homo sapiens (human))
BDBM321471
PNG
(4-[5-(azetidine-1-carbonyl)-2-methoxy-phenyl]-6-[(...)
Show SMILES COc1ccc(cc1-c1cn(C\C=C\C)c(=O)c2[nH]ccc12)C(=O)N1CCC1
Show InChI InChI=1S/C22H23N3O3/c1-3-4-10-25-14-18(16-8-9-23-20(16)22(25)27)17-13-15(6-7-19(17)28-2)21(26)24-11-5-12-24/h3-4,6-9,13-14,23H,5,10-12H2,1-2H3/b4-3+
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n/an/a 1.80E+3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD4 BD1 (aa 42-168)


(Homo sapiens (human))
BDBM321369
PNG
(7-[6-[(E)-but-2-enyl]-7-oxo-1H-pyrrolo[2,3-c]pyrid...)
Show SMILES C\C=C\Cn1cc(-c2ccc3NC(=O)CC(C)Nc3c2)c2cc[nH]c2c1=O
Show InChI InChI=1S/C21H22N4O2/c1-3-4-9-25-12-16(15-7-8-22-20(15)21(25)27)14-5-6-17-18(11-14)23-13(2)10-19(26)24-17/h3-8,11-13,22-23H,9-10H2,1-2H3,(H,24,26)/b4-3+
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n/an/a 1.90E+3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to homogeneity. BRD4 binding and inhibition was assessed by monitoring the...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
CECR2 (aa 424-538)


(Homo sapiens (human))
BDBM321455
PNG
(4-[6-[(E)-but-2-enyl]-7-oxo-1H-pyrrolo[2,3-c]pyrid...)
Show SMILES C\C=C\Cn1cc(-c2ccc(C(=O)N(C)C)c(Cl)c2)c2cc[nH]c2c1=O
Show InChI InChI=1S/C20H20ClN3O2/c1-4-5-10-24-12-16(14-8-9-22-18(14)20(24)26)13-6-7-15(17(21)11-13)19(25)23(2)3/h4-9,11-12,22H,10H2,1-3H3/b5-4+
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n/an/a 2.00E+3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
CECR2 (aa 424-538)


(Homo sapiens (human))
BDBM321449
PNG
(3-[6-(2-methoxyethyl)-7-oxo-1H-pyrrolo[2,3-c]pyrid...)
Show SMILES COCCn1cc(-c2cccc(c2)C(=O)N(C)C)c2cc[nH]c2c1=O
Show InChI InChI=1S/C19H21N3O3/c1-21(2)18(23)14-6-4-5-13(11-14)16-12-22(9-10-25-3)19(24)17-15(16)7-8-20-17/h4-8,11-12,20H,9-10H2,1-3H3
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n/an/a 2.00E+3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD4 BD1 (aa 42-168)


(Homo sapiens (human))
BDBM321341
PNG
(3-[6-(2-cyclopropylethyl)-7-oxo-1H-pyrrolo[2,3-c]p...)
Show SMILES CN(C)C(=O)c1cccc(c1)-c1cn(CCC2CC2)c(=O)c2[nH]ccc12
Show InChI InChI=1S/C21H23N3O2/c1-23(2)20(25)16-5-3-4-15(12-16)18-13-24(11-9-14-6-7-14)21(26)19-17(18)8-10-22-19/h3-5,8,10,12-14,22H,6-7,9,11H2,1-2H3
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n/an/a 2.10E+3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to homogeneity. BRD4 binding and inhibition was assessed by monitoring the...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD4 BD1 (aa 42-168)


(Homo sapiens (human))
BDBM321353
PNG
(6-but-2-enyl-4-(4-tert-butylphenyl)-1H-pyrrolo[2,3...)
Show SMILES C\C=C\Cn1cc(-c2ccc(cc2)C(C)(C)C)c2cc[nH]c2c1=O
Show InChI InChI=1S/C21H24N2O/c1-5-6-13-23-14-18(17-11-12-22-19(17)20(23)24)15-7-9-16(10-8-15)21(2,3)4/h5-12,14,22H,13H2,1-4H3/b6-5+
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n/an/a 2.10E+3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to homogeneity. BRD4 binding and inhibition was assessed by monitoring the...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD4 BD1 (aa 42-168)


(Homo sapiens (human))
BDBM321368
PNG
(3-(6-butyl-2-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridin...)
Show SMILES CCCCn1cc(-c2cccc(c2)C(=O)N(C)C)c2cc(C)[nH]c2c1=O
Show InChI InChI=1S/C21H25N3O2/c1-5-6-10-24-13-18(17-11-14(2)22-19(17)21(24)26)15-8-7-9-16(12-15)20(25)23(3)4/h7-9,11-13,22H,5-6,10H2,1-4H3
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n/an/a 2.30E+3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to homogeneity. BRD4 binding and inhibition was assessed by monitoring the...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD4 BD1 (aa 42-168)


(Homo sapiens (human))
BDBM321340
PNG
(3-(6-butyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl)-N,...)
Show SMILES CCCCn1cc(-c2cccc(c2)C(=O)N(C)C)c2cc[nH]c2c1=O
Show InChI InChI=1S/C20H23N3O2/c1-4-5-11-23-13-17(16-9-10-21-18(16)20(23)25)14-7-6-8-15(12-14)19(24)22(2)3/h6-10,12-13,21H,4-5,11H2,1-3H3
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n/an/a 2.60E+3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to homogeneity. BRD4 binding and inhibition was assessed by monitoring the...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD4 BD1 (aa 42-168)


(Homo sapiens (human))
BDBM321344
PNG
(N,N-dimethyl-3-[7-oxo-6-[(E)-pent-2-enyl]-1H-pyrro...)
Show SMILES CC\C=C\Cn1cc(-c2cccc(c2)C(=O)N(C)C)c2cc[nH]c2c1=O
Show InChI InChI=1S/C21H23N3O2/c1-4-5-6-12-24-14-18(17-10-11-22-19(17)21(24)26)15-8-7-9-16(13-15)20(25)23(2)3/h5-11,13-14,22H,4,12H2,1-3H3/b6-5+
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n/an/a 2.70E+3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to homogeneity. BRD4 binding and inhibition was assessed by monitoring the...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD4 BD1 (aa 42-168)


(Homo sapiens (human))
BDBM321352
PNG
(3-(6-but-2-enyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-y...)
Show SMILES C\C=C\Cn1cc(-c2cc(F)cc(c2)C(N)=O)c2cc[nH]c2c1=O
Show InChI InChI=1S/C18H16FN3O2/c1-2-3-6-22-10-15(14-4-5-21-16(14)18(22)24)11-7-12(17(20)23)9-13(19)8-11/h2-5,7-10,21H,6H2,1H3,(H2,20,23)/b3-2+
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n/an/a 3.00E+3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to homogeneity. BRD4 binding and inhibition was assessed by monitoring the...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (human))
BDBM321444
PNG
(6-but-2-enyl-4-[4-(4-methylpiperazine-1-carbonyl)p...)
Show SMILES C\C=C\Cn1cc(-c2ccc(cc2)C(=O)N2CCN(C)CC2)c2cc[nH]c2c1=O
Show InChI InChI=1S/C23H26N4O2/c1-3-4-11-27-16-20(19-9-10-24-21(19)23(27)29)17-5-7-18(8-6-17)22(28)26-14-12-25(2)13-15-26/h3-10,16,24H,11-15H2,1-2H3/b4-3+
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n/an/a 3.30E+3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CECR2424-538 was cloned, expressed, and purified to homogeneity. CECR2 binding and inhibition was assessed by monitoring the ...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
CECR2 (aa 424-538)


(Homo sapiens (human))
BDBM321457
PNG
(3-[6-(2-cyclopropylethyl)-7-oxo-1H-pyrrolo[2,3-c]p...)
Show SMILES COc1ccc(cc1-c1cn(CCC2CC2)c(=O)c2[nH]ccc12)C#N
Show InChI InChI=1S/C20H19N3O2/c1-25-18-5-4-14(11-21)10-16(18)17-12-23(9-7-13-2-3-13)20(24)19-15(17)6-8-22-19/h4-6,8,10,12-13,22H,2-3,7,9H2,1H3
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n/an/a 3.40E+3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (human))
BDBM321445
PNG
(6-but-2-enyl-4-[4-(pyrrolidine-1-carbonyl)phenyl]-...)
Show SMILES C\C=C\Cn1cc(-c2ccc(cc2)C(=O)N2CCCC2)c2cc[nH]c2c1=O
Show InChI InChI=1S/C22H23N3O2/c1-2-3-12-25-15-19(18-10-11-23-20(18)22(25)27)16-6-8-17(9-7-16)21(26)24-13-4-5-14-24/h2-3,6-11,15,23H,4-5,12-14H2,1H3/b3-2+
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n/an/a 3.50E+3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CECR2424-538 was cloned, expressed, and purified to homogeneity. CECR2 binding and inhibition was assessed by monitoring the ...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD4 BD1 (aa 42-168)


(Homo sapiens (human))
BDBM321346
PNG
(3-[6-(cyclobutylmethyl)-7-oxo-1H-pyrrolo[2,3-c]pyr...)
Show SMILES CN(C)C(=O)c1cccc(c1)-c1cn(CC2CCC2)c(=O)c2[nH]ccc12
Show InChI InChI=1S/C21H23N3O2/c1-23(2)20(25)16-8-4-7-15(11-16)18-13-24(12-14-5-3-6-14)21(26)19-17(18)9-10-22-19/h4,7-11,13-14,22H,3,5-6,12H2,1-2H3
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n/an/a 3.60E+3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to homogeneity. BRD4 binding and inhibition was assessed by monitoring the...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD4 BD1 (aa 42-168)


(Homo sapiens (human))
BDBM321349
PNG
(N,N-dimethyl-3-(7-oxo-6-pentyl-1H-pyrrolo[2,3-c]py...)
Show SMILES CCCCCn1cc(-c2cccc(c2)C(=O)N(C)C)c2cc[nH]c2c1=O
Show InChI InChI=1S/C21H25N3O2/c1-4-5-6-12-24-14-18(17-10-11-22-19(17)21(24)26)15-8-7-9-16(13-15)20(25)23(2)3/h7-11,13-14,22H,4-6,12H2,1-3H3
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n/an/a 4.50E+3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to homogeneity. BRD4 binding and inhibition was assessed by monitoring the...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
CECR2 (aa 424-538)


(Homo sapiens (human))
BDBM321454
PNG
(6-but-2-enyl-4-[4-(hydroxymethyl)phenyl]-1H-pyrrol...)
Show SMILES C\C=C\Cn1cc(-c2ccc(CO)cc2)c2cc[nH]c2c1=O
Show InChI InChI=1S/C18H18N2O2/c1-2-3-10-20-11-16(14-6-4-13(12-21)5-7-14)15-8-9-19-17(15)18(20)22/h2-9,11,19,21H,10,12H2,1H3/b3-2+
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n/an/a 4.50E+3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
CECR2 (aa 424-538)


(Homo sapiens (human))
BDBM321447
PNG
(N,N-dimethyl-3-[6-(3-methylbut-2-enyl)-7-oxo-1H-py...)
Show SMILES CN(C)C(=O)c1cccc(c1)-c1cn(CC=C(C)C)c(=O)c2[nH]ccc12
Show InChI InChI=1S/C21H23N3O2/c1-14(2)9-11-24-13-18(17-8-10-22-19(17)21(24)26)15-6-5-7-16(12-15)20(25)23(3)4/h5-10,12-13,22H,11H2,1-4H3
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n/an/a 5.20E+3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
CECR2 (aa 424-538)


(Homo sapiens (human))
BDBM321451
PNG
(3-[6-(cyclopropylmethyl)-7-oxo-1H-pyrrolo[2,3-c]py...)
Show SMILES CN(C)C(=O)c1cccc(c1)-c1cn(CC2CC2)c(=O)c2[nH]ccc12
Show InChI InChI=1S/C20H21N3O2/c1-22(2)19(24)15-5-3-4-14(10-15)17-12-23(11-13-6-7-13)20(25)18-16(17)8-9-21-18/h3-5,8-10,12-13,21H,6-7,11H2,1-2H3
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n/an/a 5.60E+3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
TAF1-BD2 (aa 1504-1635)


(Homo sapiens (human))
BDBM321446
PNG
(4-(6-but-2-enyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-y...)
Show SMILES C\C=C\Cn1cc(-c2ccc(cc2)C(=O)N(C)C)c2cc[nH]c2c1=O
Show InChI InChI=1S/C20H21N3O2/c1-4-5-12-23-13-17(16-10-11-21-18(16)20(23)25)14-6-8-15(9-7-14)19(24)22(2)3/h4-11,13,21H,12H2,1-3H3/b5-4+
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n/an/a 5.70E+3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CECR2424-538 was cloned, expressed, and purified to homogeneity. CECR2 binding and inhibition was assessed by monitoring the ...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD4 BD1 (aa 42-168)


(Homo sapiens (human))
BDBM321342
PNG
(3-[6-(cyclopentylmethyl)-7-oxo-1H-pyrrolo[2,3-c]py...)
Show SMILES CN(C)C(=O)c1cccc(c1)-c1cn(CC2CCCC2)c(=O)c2[nH]ccc12
Show InChI InChI=1S/C22H25N3O2/c1-24(2)21(26)17-9-5-8-16(12-17)19-14-25(13-15-6-3-4-7-15)22(27)20-18(19)10-11-23-20/h5,8-12,14-15,23H,3-4,6-7,13H2,1-2H3
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n/an/a 6.40E+3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to homogeneity. BRD4 binding and inhibition was assessed by monitoring the...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD4 BD1 (aa 42-168)


(Homo sapiens (human))
BDBM321350
PNG
(3-(6-isobutyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl)...)
Show SMILES CC(C)Cn1cc(-c2cccc(c2)C(=O)N(C)C)c2cc[nH]c2c1=O
Show InChI InChI=1S/C20H23N3O2/c1-13(2)11-23-12-17(16-8-9-21-18(16)20(23)25)14-6-5-7-15(10-14)19(24)22(3)4/h5-10,12-13,21H,11H2,1-4H3
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n/an/a 8.00E+3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to homogeneity. BRD4 binding and inhibition was assessed by monitoring the...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD4 BD1 (aa 42-168)


(Homo sapiens (human))
BDBM321362
PNG
(6-(2-furylmethyl)-4-phenyl-1H-pyrrolo[2,3-c]pyridi...)
Show SMILES O=c1n(Cc2ccco2)cc(-c2ccccc2)c2cc[nH]c12
Show InChI InChI=1S/C18H14N2O2/c21-18-17-15(8-9-19-17)16(13-5-2-1-3-6-13)12-20(18)11-14-7-4-10-22-14/h1-10,12,19H,11H2
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n/an/a 8.40E+3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to homogeneity. BRD4 binding and inhibition was assessed by monitoring the...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
CECR2 (aa 424-538)


(Homo sapiens (human))
BDBM321450
PNG
(3-[6-(3-methoxypropyl)-7-oxo-1H-pyrrolo[2,3-c]pyri...)
Show SMILES COCCCn1cc(-c2cccc(c2)C(=O)N(C)C)c2cc[nH]c2c1=O
Show InChI InChI=1S/C20H23N3O3/c1-22(2)19(24)15-7-4-6-14(12-15)17-13-23(10-5-11-26-3)20(25)18-16(17)8-9-21-18/h4,6-9,12-13,21H,5,10-11H2,1-3H3
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n/an/a 9.30E+3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD4 BD1 (aa 42-168)


(Homo sapiens (human))
BDBM321347
PNG
(3-[6-(2-cyclohexylethyl)-7-oxo-1H-pyrrolo[2,3-c]py...)
Show SMILES CN(C)C(=O)c1cccc(c1)-c1cn(CCC2CCCCC2)c(=O)c2[nH]ccc12
Show InChI InChI=1S/C24H29N3O2/c1-26(2)23(28)19-10-6-9-18(15-19)21-16-27(14-12-17-7-4-3-5-8-17)24(29)22-20(21)11-13-25-22/h6,9-11,13,15-17,25H,3-5,7-8,12,14H2,1-2H3
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n/an/a 1.20E+4n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to homogeneity. BRD4 binding and inhibition was assessed by monitoring the...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD4 BD1 (aa 42-168)


(Homo sapiens (human))
BDBM321345
PNG
(3-[6-(cyclohexylmethyl)-7-oxo-1H-pyrrolo[2,3-c]pyr...)
Show SMILES CN(C)C(=O)c1cccc(c1)-c1cn(CC2CCCCC2)c(=O)c2[nH]ccc12
Show InChI InChI=1S/C23H27N3O2/c1-25(2)22(27)18-10-6-9-17(13-18)20-15-26(14-16-7-4-3-5-8-16)23(28)21-19(20)11-12-24-21/h6,9-13,15-16,24H,3-5,7-8,14H2,1-2H3
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n/an/a 1.50E+4n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to homogeneity. BRD4 binding and inhibition was assessed by monitoring the...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%