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Patent code US10183931

Compile Data Set for Download or QSAR
Found 91 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM322158
PNG
(2-(3-(4-((1H-indazol-5-yl)amino)-6-(4-methylpipera...)
Show SMILES CC(C)NC(=O)COc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)cc(n1)N1CCN(C)CC1
Show InChI InChI=1S/C27H32N8O2/c1-18(2)29-26(36)17-37-22-6-4-5-19(14-22)27-31-24(15-25(32-27)35-11-9-34(3)10-12-35)30-21-7-8-23-20(13-21)16-28-33-23/h4-8,13-16,18H,9-12,17H2,1-3H3,(H,28,33)(H,29,36)(H,30,31,32)
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10n/an/an/an/an/an/an/an/a



Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM322152
PNG
((R)-2-(3-(4-((1H-indazol-5-yl)amino)pyrimidin-2-yl...)
Show SMILES O=C(COc1cccc(c1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1)N[C@@H]1CCNC1
Show InChI InChI=1S/C23H23N7O2/c31-22(28-18-6-8-24-13-18)14-32-19-3-1-2-15(11-19)23-25-9-7-21(29-23)27-17-4-5-20-16(10-17)12-26-30-20/h1-5,7,9-12,18,24H,6,8,13-14H2,(H,26,30)(H,28,31)(H,25,27,29)/t18-/m1/s1
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20n/an/an/an/an/an/an/an/a



Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM322158
PNG
(2-(3-(4-((1H-indazol-5-yl)amino)-6-(4-methylpipera...)
Show SMILES CC(C)NC(=O)COc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)cc(n1)N1CCN(C)CC1
Show InChI InChI=1S/C27H32N8O2/c1-18(2)29-26(36)17-37-22-6-4-5-19(14-22)27-31-24(15-25(32-27)35-11-9-34(3)10-12-35)30-21-7-8-23-20(13-21)16-28-33-23/h4-8,13-16,18H,9-12,17H2,1-3H3,(H,28,33)(H,29,36)(H,30,31,32)
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Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM322153
PNG
(2-(3-(4-((1H-indazol-5-yl)amino)-5-methylpyrimidin...)
Show SMILES Cc1cnc(nc1Nc1ccc2[nH]ncc2c1)-c1cccc(OCC(=O)NC2CC2)c1
Show InChI InChI=1S/C23H22N6O2/c1-14-11-24-23(28-22(14)27-18-7-8-20-16(9-18)12-25-29-20)15-3-2-4-19(10-15)31-13-21(30)26-17-5-6-17/h2-4,7-12,17H,5-6,13H2,1H3,(H,25,29)(H,26,30)(H,24,27,28)
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30n/an/an/an/an/an/an/an/a



Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM14029
PNG
((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...)
Show SMILES C[C@@H](N)[C@H]1CC[C@@H](CC1)C(=O)Nc1ccncc1
Show InChI InChI=1S/C14H21N3O/c1-10(15)11-2-4-12(5-3-11)14(18)17-13-6-8-16-9-7-13/h6-12H,2-5,15H2,1H3,(H,16,17,18)/t10-,11-,12-/m1/s1
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40n/an/an/an/an/an/an/an/a



Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM322155
PNG
(US10183931, SLx-2119)
Show SMILES CC(C)NC(=O)COc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2ccccc2n1
Show InChI InChI=1S/C26H24N6O2/c1-16(2)28-24(33)15-34-20-7-5-6-17(13-20)25-30-23-9-4-3-8-21(23)26(31-25)29-19-10-11-22-18(12-19)14-27-32-22/h3-14,16H,15H2,1-2H3,(H,27,32)(H,28,33)(H,29,30,31)
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40n/an/an/an/an/an/an/an/a



Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM14029
PNG
((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...)
Show SMILES C[C@@H](N)[C@H]1CC[C@@H](CC1)C(=O)Nc1ccncc1
Show InChI InChI=1S/C14H21N3O/c1-10(15)11-2-4-12(5-3-11)14(18)17-13-6-8-16-9-7-13/h6-12H,2-5,15H2,1H3,(H,16,17,18)/t10-,11-,12-/m1/s1
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60n/an/an/an/an/an/an/an/a



Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM322152
PNG
((R)-2-(3-(4-((1H-indazol-5-yl)amino)pyrimidin-2-yl...)
Show SMILES O=C(COc1cccc(c1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1)N[C@@H]1CCNC1
Show InChI InChI=1S/C23H23N7O2/c31-22(28-18-6-8-24-13-18)14-32-19-3-1-2-15(11-19)23-25-9-7-21(29-23)27-17-4-5-20-16(10-17)12-26-30-20/h1-5,7,9-12,18,24H,6,8,13-14H2,(H,26,30)(H,28,31)(H,25,27,29)/t18-/m1/s1
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70n/an/an/an/an/an/an/an/a



Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM322154
PNG
(2-(3-(4-((1H-indazol-5-yl)amino)-5-methylpyrimidin...)
Show SMILES Cc1cnc(nc1Nc1ccc2[nH]ncc2c1)-c1cccc(OCC(=O)NC2CCNCC2)c1
Show InChI InChI=1S/C25H27N7O2/c1-16-13-27-25(31-24(16)30-20-5-6-22-18(11-20)14-28-32-22)17-3-2-4-21(12-17)34-15-23(33)29-19-7-9-26-10-8-19/h2-6,11-14,19,26H,7-10,15H2,1H3,(H,28,32)(H,29,33)(H,27,30,31)
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80n/an/an/an/an/an/an/an/a



Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM322157
PNG
(2-(3-(4-((1H-indazol-5-yl)amino)pyrimidin-2-yl)phe...)
Show SMILES O=C(COc1cccc(c1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1)N1CCS(=O)(=O)CC1
Show InChI InChI=1S/C23H22N6O4S/c30-22(29-8-10-34(31,32)11-9-29)15-33-19-3-1-2-16(13-19)23-24-7-6-21(27-23)26-18-4-5-20-17(12-18)14-25-28-20/h1-7,12-14H,8-11,15H2,(H,25,28)(H,24,26,27)
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170n/an/an/an/an/an/an/an/a



Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM322159
PNG
((R)-2-(3-(4-((1H-indazol-5-yl)amino)pyrimidin-2-yl...)
Show SMILES NC(=O)COc1cccc(c1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C19H16N6O2/c20-17(26)11-27-15-3-1-2-12(9-15)19-21-7-6-18(24-19)23-14-4-5-16-13(8-14)10-22-25-16/h1-10H,11H2,(H2,20,26)(H,22,25)(H,21,23,24)
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180n/an/an/an/an/an/an/an/a



Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM322154
PNG
(2-(3-(4-((1H-indazol-5-yl)amino)-5-methylpyrimidin...)
Show SMILES Cc1cnc(nc1Nc1ccc2[nH]ncc2c1)-c1cccc(OCC(=O)NC2CCNCC2)c1
Show InChI InChI=1S/C25H27N7O2/c1-16-13-27-25(31-24(16)30-20-5-6-22-18(11-20)14-28-32-22)17-3-2-4-21(12-17)34-15-23(33)29-19-7-9-26-10-8-19/h2-6,11-14,19,26H,7-10,15H2,1H3,(H,28,32)(H,29,33)(H,27,30,31)
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Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM322155
PNG
(US10183931, SLx-2119)
Show SMILES CC(C)NC(=O)COc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2ccccc2n1
Show InChI InChI=1S/C26H24N6O2/c1-16(2)28-24(33)15-34-20-7-5-6-17(13-20)25-30-23-9-4-3-8-21(23)26(31-25)29-19-10-11-22-18(12-19)14-27-32-22/h3-14,16H,15H2,1-2H3,(H,27,32)(H,28,33)(H,29,30,31)
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500n/an/an/an/an/an/an/an/a



Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM322159
PNG
((R)-2-(3-(4-((1H-indazol-5-yl)amino)pyrimidin-2-yl...)
Show SMILES NC(=O)COc1cccc(c1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C19H16N6O2/c20-17(26)11-27-15-3-1-2-12(9-15)19-21-7-6-18(24-19)23-14-4-5-16-13(8-14)10-22-25-16/h1-10H,11H2,(H2,20,26)(H,22,25)(H,21,23,24)
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870n/an/an/an/an/an/an/an/a



Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM322153
PNG
(2-(3-(4-((1H-indazol-5-yl)amino)-5-methylpyrimidin...)
Show SMILES Cc1cnc(nc1Nc1ccc2[nH]ncc2c1)-c1cccc(OCC(=O)NC2CC2)c1
Show InChI InChI=1S/C23H22N6O2/c1-14-11-24-23(28-22(14)27-18-7-8-20-16(9-18)12-25-29-20)15-3-2-4-19(10-15)31-13-21(30)26-17-5-6-17/h2-4,7-12,17H,5-6,13H2,1H3,(H,25,29)(H,26,30)(H,24,27,28)
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2.01E+3n/an/an/an/an/an/an/an/a



Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM322176
PNG
(US10183931, Example 176)
Show SMILES O=C(Nc1cccnc1)c1cccc(c1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C23H17N7O/c31-23(28-19-5-2-9-24-14-19)16-4-1-3-15(11-16)22-25-10-8-21(29-22)27-18-6-7-20-17(12-18)13-26-30-20/h1-14H,(H,26,30)(H,28,31)(H,25,27,29)
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n/an/a 13n/an/an/an/an/an/a



Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM322165
PNG
(US10183931, Example 166)
Show SMILES Cc1cnc(nc1Nc1ccc2[nH]ncc2c1)-c1cccc(OCC(=O)Nc2ccnnc2)c1
Show InChI InChI=1S/C24H20N8O2/c1-15-11-25-24(31-23(15)30-18-5-6-21-17(9-18)12-28-32-21)16-3-2-4-20(10-16)34-14-22(33)29-19-7-8-26-27-13-19/h2-13H,14H2,1H3,(H,28,32)(H,25,30,31)(H,26,29,33)
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Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM322167
PNG
(US10183931, Example 168)
Show SMILES CC(C)NC(=O)COc1cccc(c1)-c1ncc(c(Nc2ccc3[nH]ncc3c2)n1)C(F)(F)F
Show InChI InChI=1S/C23H21F3N6O2/c1-13(2)29-20(33)12-34-17-5-3-4-14(9-17)21-27-11-18(23(24,25)26)22(31-21)30-16-6-7-19-15(8-16)10-28-32-19/h3-11,13H,12H2,1-2H3,(H,28,32)(H,29,33)(H,27,30,31)
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n/an/a 30n/an/an/an/an/an/a



Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM322172
PNG
(US10183931, Example 173)
Show SMILES Cc1nc(nc(Nc2ccc3[nH]ncc3c2)c1C)-c1cccc(OCC(=O)NC2CCC2)c1
Show InChI InChI=1S/C25H26N6O2/c1-15-16(2)27-25(30-24(15)29-20-9-10-22-18(11-20)13-26-31-22)17-5-3-8-21(12-17)33-14-23(32)28-19-6-4-7-19/h3,5,8-13,19H,4,6-7,14H2,1-2H3,(H,26,31)(H,28,32)(H,27,29,30)
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n/an/a 30n/an/an/an/an/an/a



Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM322153
PNG
(2-(3-(4-((1H-indazol-5-yl)amino)-5-methylpyrimidin...)
Show SMILES Cc1cnc(nc1Nc1ccc2[nH]ncc2c1)-c1cccc(OCC(=O)NC2CC2)c1
Show InChI InChI=1S/C23H22N6O2/c1-14-11-24-23(28-22(14)27-18-7-8-20-16(9-18)12-25-29-20)15-3-2-4-19(10-15)31-13-21(30)26-17-5-6-17/h2-4,7-12,17H,5-6,13H2,1H3,(H,25,29)(H,26,30)(H,24,27,28)
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Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM322174
PNG
(N-(3-(4-((1H-indazol-5-yl)amino)pyrimidin-2-yl)phe...)
Show SMILES O=C(Nc1cccc(c1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1)N1CCOCC1
Show InChI InChI=1S/C22H21N7O2/c30-22(29-8-10-31-11-9-29)26-17-3-1-2-15(12-17)21-23-7-6-20(27-21)25-18-4-5-19-16(13-18)14-24-28-19/h1-7,12-14H,8-11H2,(H,24,28)(H,26,30)(H,23,25,27)
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Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM322162
PNG
(2-(3-(4-((1H-indazol-5-yl)amino)-6-(piperazin-1-yl...)
Show SMILES CC(C)NC(=O)COc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)cc(n1)N1CCNCC1
Show InChI InChI=1S/C26H30N8O2/c1-17(2)29-25(35)16-36-21-5-3-4-18(13-21)26-31-23(14-24(32-26)34-10-8-27-9-11-34)30-20-6-7-22-19(12-20)15-28-33-22/h3-7,12-15,17,27H,8-11,16H2,1-2H3,(H,28,33)(H,29,35)(H,30,31,32)
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Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM322182
PNG
(N-(2-(3-(2-(isopropylamino)ethoxy)phenyl)pyrimidin...)
Show SMILES CC(C)NCCOc1cccc(c1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C22H24N6O/c1-15(2)23-10-11-29-19-5-3-4-16(13-19)22-24-9-8-21(27-22)26-18-6-7-20-17(12-18)14-25-28-20/h3-9,12-15,23H,10-11H2,1-2H3,(H,25,28)(H,24,26,27)
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Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM322164
PNG
(US10183931, Example 165)
Show SMILES O=C(COc1cccc(c1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1)NC1CCC1
Show InChI InChI=1S/C23H22N6O2/c30-22(27-17-4-2-5-17)14-31-19-6-1-3-15(12-19)23-24-10-9-21(28-23)26-18-7-8-20-16(11-18)13-25-29-20/h1,3,6-13,17H,2,4-5,14H2,(H,25,29)(H,27,30)(H,24,26,28)
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Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM322166
PNG
(US10183931, Example 167)
Show SMILES Cc1cnc(nc1Nc1ccc2[nH]ncc2c1)-c1cccc(OCC(=O)NC2CCCC2)c1
Show InChI InChI=1S/C25H26N6O2/c1-16-13-26-25(30-24(16)29-20-9-10-22-18(11-20)14-27-31-22)17-5-4-8-21(12-17)33-15-23(32)28-19-6-2-3-7-19/h4-5,8-14,19H,2-3,6-7,15H2,1H3,(H,27,31)(H,28,32)(H,26,29,30)
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Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM322163
PNG
(US10183931, Example 164)
Show SMILES CC(C)NC(=O)COc1cccc(c1)-c1ncc(C)c(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C23H24N6O2/c1-14(2)26-21(30)13-31-19-6-4-5-16(10-19)23-24-11-15(3)22(28-23)27-18-7-8-20-17(9-18)12-25-29-20/h4-12,14H,13H2,1-3H3,(H,25,29)(H,26,30)(H,24,27,28)
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Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM322160
PNG
(2-(3-(4-((1H-indazol-5-yl)amino)pyrimidin-2-yl)phe...)
Show SMILES CC(C)NC(=O)COc1cccc(c1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C22H22N6O2/c1-14(2)25-21(29)13-30-18-5-3-4-15(11-18)22-23-9-8-20(27-22)26-17-6-7-19-16(10-17)12-24-28-19/h3-12,14H,13H2,1-2H3,(H,24,28)(H,25,29)(H,23,26,27)
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Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM322154
PNG
(2-(3-(4-((1H-indazol-5-yl)amino)-5-methylpyrimidin...)
Show SMILES Cc1cnc(nc1Nc1ccc2[nH]ncc2c1)-c1cccc(OCC(=O)NC2CCNCC2)c1
Show InChI InChI=1S/C25H27N7O2/c1-16-13-27-25(31-24(16)30-20-5-6-22-18(11-20)14-28-32-22)17-3-2-4-21(12-17)34-15-23(33)29-19-7-9-26-10-8-19/h2-6,11-14,19,26H,7-10,15H2,1H3,(H,28,32)(H,29,33)(H,27,30,31)
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Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM322169
PNG
(US10183931, Example 170)
Show SMILES Cc1cc(Nc2ccc3[nH]ncc3c2)nc(n1)-c1cccc(OCC(=O)NC2CC2)c1
Show InChI InChI=1S/C23H22N6O2/c1-14-9-21(26-18-7-8-20-16(10-18)12-24-29-20)28-23(25-14)15-3-2-4-19(11-15)31-13-22(30)27-17-5-6-17/h2-4,7-12,17H,5-6,13H2,1H3,(H,24,29)(H,27,30)(H,25,26,28)
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Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM322161
PNG
(US10183931, Example 163)
Show SMILES O=C(COc1cccc(c1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1)NC1CC1
Show InChI InChI=1S/C22H20N6O2/c29-21(26-16-4-5-16)13-30-18-3-1-2-14(11-18)22-23-9-8-20(27-22)25-17-6-7-19-15(10-17)12-24-28-19/h1-3,6-12,16H,4-5,13H2,(H,24,28)(H,26,29)(H,23,25,27)
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Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM322170
PNG
(US10183931, Example 171)
Show SMILES Cc1nc(nc(Nc2ccc3[nH]ncc3c2)c1C)-c1cccc(OCC(=O)NC2CC2)c1
Show InChI InChI=1S/C24H24N6O2/c1-14-15(2)26-24(29-23(14)28-19-8-9-21-17(10-19)12-25-30-21)16-4-3-5-20(11-16)32-13-22(31)27-18-6-7-18/h3-5,8-12,18H,6-7,13H2,1-2H3,(H,25,30)(H,27,31)(H,26,28,29)
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Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM322184
PNG
(N-(2-(3-methoxyphenyl)-6-(piperazin-1-yl)pyrimidin...)
Show SMILES COc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)cc(n1)N1CCNCC1
Show InChI InChI=1S/C22H23N7O/c1-30-18-4-2-3-15(12-18)22-26-20(13-21(27-22)29-9-7-23-8-10-29)25-17-5-6-19-16(11-17)14-24-28-19/h2-6,11-14,23H,7-10H2,1H3,(H,24,28)(H,25,26,27)
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Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM322171
PNG
(US10183931, Example 172)
Show SMILES CC(C)NC(=O)COc1cccc(c1)-c1nc(C)c(C)c(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C24H26N6O2/c1-14(2)26-22(31)13-32-20-7-5-6-17(11-20)24-27-16(4)15(3)23(29-24)28-19-8-9-21-18(10-19)12-25-30-21/h5-12,14H,13H2,1-4H3,(H,25,30)(H,26,31)(H,27,28,29)
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Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM322173
PNG
(US10183931, Example 174)
Show SMILES O=C(CN1CCOCC1)Nc1cccc(c1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C23H23N7O2/c31-22(15-30-8-10-32-11-9-30)27-18-3-1-2-16(12-18)23-24-7-6-21(28-23)26-19-4-5-20-17(13-19)14-25-29-20/h1-7,12-14H,8-11,15H2,(H,25,29)(H,27,31)(H,24,26,28)
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Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM322184
PNG
(N-(2-(3-methoxyphenyl)-6-(piperazin-1-yl)pyrimidin...)
Show SMILES COc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)cc(n1)N1CCNCC1
Show InChI InChI=1S/C22H23N7O/c1-30-18-4-2-3-15(12-18)22-26-20(13-21(27-22)29-9-7-23-8-10-29)25-17-5-6-19-16(11-17)14-24-28-19/h2-6,11-14,23H,7-10H2,1H3,(H,24,28)(H,25,26,27)
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Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM322158
PNG
(2-(3-(4-((1H-indazol-5-yl)amino)-6-(4-methylpipera...)
Show SMILES CC(C)NC(=O)COc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)cc(n1)N1CCN(C)CC1
Show InChI InChI=1S/C27H32N8O2/c1-18(2)29-26(36)17-37-22-6-4-5-19(14-22)27-31-24(15-25(32-27)35-11-9-34(3)10-12-35)30-21-7-8-23-20(13-21)16-28-33-23/h4-8,13-16,18H,9-12,17H2,1-3H3,(H,28,33)(H,29,36)(H,30,31,32)
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Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM322181
PNG
(US10183931, Example 179)
Show SMILES O=C(NC1CCOCC1)c1cccc(c1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C23H22N6O2/c30-23(27-18-7-10-31-11-8-18)16-3-1-2-15(12-16)22-24-9-6-21(28-22)26-19-4-5-20-17(13-19)14-25-29-20/h1-6,9,12-14,18H,7-8,10-11H2,(H,25,29)(H,27,30)(H,24,26,28)
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Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM322158
PNG
(2-(3-(4-((1H-indazol-5-yl)amino)-6-(4-methylpipera...)
Show SMILES CC(C)NC(=O)COc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)cc(n1)N1CCN(C)CC1
Show InChI InChI=1S/C27H32N8O2/c1-18(2)29-26(36)17-37-22-6-4-5-19(14-22)27-31-24(15-25(32-27)35-11-9-34(3)10-12-35)30-21-7-8-23-20(13-21)16-28-33-23/h4-8,13-16,18H,9-12,17H2,1-3H3,(H,28,33)(H,29,36)(H,30,31,32)
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Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM322183
PNG
(3-(4-((1H-indazol-5-yl)amino)pyrimidin-2-yl)-N-(pi...)
Show SMILES O=C(NC1CCNCC1)c1cccc(c1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C23H23N7O/c31-23(28-18-6-9-24-10-7-18)16-3-1-2-15(12-16)22-25-11-8-21(29-22)27-19-4-5-20-17(13-19)14-26-30-20/h1-5,8,11-14,18,24H,6-7,9-10H2,(H,26,30)(H,28,31)(H,25,27,29)
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Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM322185
PNG
(US10183931, Example 180)
Show SMILES CN1CCC(CC1)NC(=O)c1cccc(c1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C24H25N7O/c1-31-11-8-19(9-12-31)28-24(32)17-4-2-3-16(13-17)23-25-10-7-22(29-23)27-20-5-6-21-18(14-20)15-26-30-21/h2-7,10,13-15,19H,8-9,11-12H2,1H3,(H,26,30)(H,28,32)(H,25,27,29)
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n/an/a 380n/an/an/an/an/an/a



Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM322187
PNG
(3-(4-((1H-indazol-5-yl)amino)pyrimidin-2-yl)-N-(1,...)
Show SMILES O=C(NC1CCS(=O)(=O)CC1)c1cccc(c1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C23H22N6O3S/c30-23(27-18-7-10-33(31,32)11-8-18)16-3-1-2-15(12-16)22-24-9-6-21(28-22)26-19-4-5-20-17(13-19)14-25-29-20/h1-6,9,12-14,18H,7-8,10-11H2,(H,25,29)(H,27,30)(H,24,26,28)
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Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM322158
PNG
(2-(3-(4-((1H-indazol-5-yl)amino)-6-(4-methylpipera...)
Show SMILES CC(C)NC(=O)COc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)cc(n1)N1CCN(C)CC1
Show InChI InChI=1S/C27H32N8O2/c1-18(2)29-26(36)17-37-22-6-4-5-19(14-22)27-31-24(15-25(32-27)35-11-9-34(3)10-12-35)30-21-7-8-23-20(13-21)16-28-33-23/h4-8,13-16,18H,9-12,17H2,1-3H3,(H,28,33)(H,29,36)(H,30,31,32)
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Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM322175
PNG
(US10183931, Example 175)
Show SMILES O=C(COc1cccc(c1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1)N1CCOCC1
Show InChI InChI=1S/C23H22N6O3/c30-22(29-8-10-31-11-9-29)15-32-19-3-1-2-16(13-19)23-24-7-6-21(27-23)26-18-4-5-20-17(12-18)14-25-28-20/h1-7,12-14H,8-11,15H2,(H,25,28)(H,24,26,27)
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Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM322152
PNG
((R)-2-(3-(4-((1H-indazol-5-yl)amino)pyrimidin-2-yl...)
Show SMILES O=C(COc1cccc(c1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1)N[C@@H]1CCNC1
Show InChI InChI=1S/C23H23N7O2/c31-22(28-18-6-8-24-13-18)14-32-19-3-1-2-15(11-19)23-25-9-7-21(29-23)27-17-4-5-20-16(10-17)12-26-30-20/h1-5,7,9-12,18,24H,6,8,13-14H2,(H,26,30)(H,28,31)(H,25,27,29)/t18-/m1/s1
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Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM322179
PNG
(US10183931, Example 178)
Show SMILES O=C(NN1CCOCC1)c1cccc(c1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C22H21N7O2/c30-22(28-29-8-10-31-11-9-29)16-3-1-2-15(12-16)21-23-7-6-20(26-21)25-18-4-5-19-17(13-18)14-24-27-19/h1-7,12-14H,8-11H2,(H,24,27)(H,28,30)(H,23,25,26)
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Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM322153
PNG
(2-(3-(4-((1H-indazol-5-yl)amino)-5-methylpyrimidin...)
Show SMILES Cc1cnc(nc1Nc1ccc2[nH]ncc2c1)-c1cccc(OCC(=O)NC2CC2)c1
Show InChI InChI=1S/C23H22N6O2/c1-14-11-24-23(28-22(14)27-18-7-8-20-16(9-18)12-25-29-20)15-3-2-4-19(10-15)31-13-21(30)26-17-5-6-17/h2-4,7-12,17H,5-6,13H2,1H3,(H,25,29)(H,26,30)(H,24,27,28)
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Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM322180
PNG
(N-(2-(4-(1-aminoethyl)phenyl)pyrimidin-4-yl)-1H-in...)
Show SMILES CC(N)c1ccc(cc1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C19H18N6/c1-12(20)13-2-4-14(5-3-13)19-21-9-8-18(24-19)23-16-6-7-17-15(10-16)11-22-25-17/h2-12H,20H2,1H3,(H,22,25)(H,21,23,24)
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Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM322186
PNG
(N-(6-(2-(dimethylamino)ethoxy)-2-(3-methoxyphenyl)...)
Show SMILES COc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)cc(OCCN(C)C)n1
Show InChI InChI=1S/C22H24N6O2/c1-28(2)9-10-30-21-13-20(24-17-7-8-19-16(11-17)14-23-27-19)25-22(26-21)15-5-4-6-18(12-15)29-3/h4-8,11-14H,9-10H2,1-3H3,(H,23,27)(H,24,25,26)
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Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM322158
PNG
(2-(3-(4-((1H-indazol-5-yl)amino)-6-(4-methylpipera...)
Show SMILES CC(C)NC(=O)COc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)cc(n1)N1CCN(C)CC1
Show InChI InChI=1S/C27H32N8O2/c1-18(2)29-26(36)17-37-22-6-4-5-19(14-22)27-31-24(15-25(32-27)35-11-9-34(3)10-12-35)30-21-7-8-23-20(13-21)16-28-33-23/h4-8,13-16,18H,9-12,17H2,1-3H3,(H,28,33)(H,29,36)(H,30,31,32)
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Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM322155
PNG
(US10183931, SLx-2119)
Show SMILES CC(C)NC(=O)COc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2ccccc2n1
Show InChI InChI=1S/C26H24N6O2/c1-16(2)28-24(33)15-34-20-7-5-6-17(13-20)25-30-23-9-4-3-8-21(23)26(31-25)29-19-10-11-22-18(12-19)14-27-32-22/h3-14,16H,15H2,1-2H3,(H,27,32)(H,28,33)(H,29,30,31)
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Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM14029
PNG
((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...)
Show SMILES C[C@@H](N)[C@H]1CC[C@@H](CC1)C(=O)Nc1ccncc1
Show InChI InChI=1S/C14H21N3O/c1-10(15)11-2-4-12(5-3-11)14(18)17-13-6-8-16-9-7-13/h6-12H,2-5,15H2,1H3,(H,16,17,18)/t10-,11-,12-/m1/s1
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Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM322174
PNG
(N-(3-(4-((1H-indazol-5-yl)amino)pyrimidin-2-yl)phe...)
Show SMILES O=C(Nc1cccc(c1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1)N1CCOCC1
Show InChI InChI=1S/C22H21N7O2/c30-22(29-8-10-31-11-9-29)26-17-3-1-2-15(12-17)21-23-7-6-20(27-21)25-18-4-5-19-16(13-18)14-24-28-19/h1-7,12-14H,8-11H2,(H,24,28)(H,26,30)(H,23,25,27)
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Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM14029
PNG
((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...)
Show SMILES C[C@@H](N)[C@H]1CC[C@@H](CC1)C(=O)Nc1ccncc1
Show InChI InChI=1S/C14H21N3O/c1-10(15)11-2-4-12(5-3-11)14(18)17-13-6-8-16-9-7-13/h6-12H,2-5,15H2,1H3,(H,16,17,18)/t10-,11-,12-/m1/s1
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n/an/a 1.63E+3n/an/an/an/an/an/a



Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM322164
PNG
(US10183931, Example 165)
Show SMILES O=C(COc1cccc(c1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1)NC1CCC1
Show InChI InChI=1S/C23H22N6O2/c30-22(27-17-4-2-5-17)14-31-19-6-1-3-15(12-19)23-24-10-9-21(28-23)26-18-7-8-20-16(11-18)13-25-29-20/h1,3,6-13,17H,2,4-5,14H2,(H,25,29)(H,27,30)(H,24,26,28)
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Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM322152
PNG
((R)-2-(3-(4-((1H-indazol-5-yl)amino)pyrimidin-2-yl...)
Show SMILES O=C(COc1cccc(c1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1)N[C@@H]1CCNC1
Show InChI InChI=1S/C23H23N7O2/c31-22(28-18-6-8-24-13-18)14-32-19-3-1-2-15(11-19)23-25-9-7-21(29-23)27-17-4-5-20-16(10-17)12-26-30-20/h1-5,7,9-12,18,24H,6,8,13-14H2,(H,26,30)(H,28,31)(H,25,27,29)/t18-/m1/s1
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Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM322154
PNG
(2-(3-(4-((1H-indazol-5-yl)amino)-5-methylpyrimidin...)
Show SMILES Cc1cnc(nc1Nc1ccc2[nH]ncc2c1)-c1cccc(OCC(=O)NC2CCNCC2)c1
Show InChI InChI=1S/C25H27N7O2/c1-16-13-27-25(31-24(16)30-20-5-6-22-18(11-20)14-28-32-22)17-3-2-4-21(12-17)34-15-23(33)29-19-7-9-26-10-8-19/h2-6,11-14,19,26H,7-10,15H2,1H3,(H,28,32)(H,29,33)(H,27,30,31)
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Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM322178
PNG
(N-(2-(3-(1-aminoethyl)phenyl)pyrimidin-4-yl)-1H-in...)
Show SMILES CC(N)c1cccc(c1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C19H18N6/c1-12(20)13-3-2-4-14(9-13)19-21-8-7-18(24-19)23-16-5-6-17-15(10-16)11-22-25-17/h2-12H,20H2,1H3,(H,22,25)(H,21,23,24)
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Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM322165
PNG
(US10183931, Example 166)
Show SMILES Cc1cnc(nc1Nc1ccc2[nH]ncc2c1)-c1cccc(OCC(=O)Nc2ccnnc2)c1
Show InChI InChI=1S/C24H20N8O2/c1-15-11-25-24(31-23(15)30-18-5-6-21-17(9-18)12-28-32-21)16-3-2-4-20(10-16)34-14-22(33)29-19-7-8-26-27-13-19/h2-13H,14H2,1H3,(H,28,32)(H,25,30,31)(H,26,29,33)
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Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM322181
PNG
(US10183931, Example 179)
Show SMILES O=C(NC1CCOCC1)c1cccc(c1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C23H22N6O2/c30-23(27-18-7-10-31-11-8-18)16-3-1-2-15(12-16)22-24-9-6-21(28-22)26-19-4-5-20-17(13-19)14-25-29-20/h1-6,9,12-14,18H,7-8,10-11H2,(H,25,29)(H,27,30)(H,24,26,28)
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Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM322154
PNG
(2-(3-(4-((1H-indazol-5-yl)amino)-5-methylpyrimidin...)
Show SMILES Cc1cnc(nc1Nc1ccc2[nH]ncc2c1)-c1cccc(OCC(=O)NC2CCNCC2)c1
Show InChI InChI=1S/C25H27N7O2/c1-16-13-27-25(31-24(16)30-20-5-6-22-18(11-20)14-28-32-22)17-3-2-4-21(12-17)34-15-23(33)29-19-7-9-26-10-8-19/h2-6,11-14,19,26H,7-10,15H2,1H3,(H,28,32)(H,29,33)(H,27,30,31)
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n/an/a 2.50E+3n/an/an/an/an/an/a



Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM322173
PNG
(US10183931, Example 174)
Show SMILES O=C(CN1CCOCC1)Nc1cccc(c1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C23H23N7O2/c31-22(15-30-8-10-32-11-9-30)27-18-3-1-2-16(12-18)23-24-7-6-21(28-23)26-19-4-5-20-17(13-19)14-25-29-20/h1-7,12-14H,8-11,15H2,(H,25,29)(H,27,31)(H,24,26,28)
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n/an/a 2.80E+3n/an/an/an/an/an/a



Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM322180
PNG
(N-(2-(4-(1-aminoethyl)phenyl)pyrimidin-4-yl)-1H-in...)
Show SMILES CC(N)c1ccc(cc1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C19H18N6/c1-12(20)13-2-4-14(5-3-13)19-21-9-8-18(24-19)23-16-6-7-17-15(10-16)11-22-25-17/h2-12H,20H2,1H3,(H,22,25)(H,21,23,24)
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Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM322160
PNG
(2-(3-(4-((1H-indazol-5-yl)amino)pyrimidin-2-yl)phe...)
Show SMILES CC(C)NC(=O)COc1cccc(c1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C22H22N6O2/c1-14(2)25-21(29)13-30-18-5-3-4-15(11-18)22-23-9-8-20(27-22)26-17-6-7-19-16(10-17)12-24-28-19/h3-12,14H,13H2,1-2H3,(H,24,28)(H,25,29)(H,23,26,27)
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Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM322186
PNG
(N-(6-(2-(dimethylamino)ethoxy)-2-(3-methoxyphenyl)...)
Show SMILES COc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)cc(OCCN(C)C)n1
Show InChI InChI=1S/C22H24N6O2/c1-28(2)9-10-30-21-13-20(24-17-7-8-19-16(11-17)14-23-27-19)25-22(26-21)15-5-4-6-18(12-15)29-3/h4-8,11-14H,9-10H2,1-3H3,(H,23,27)(H,24,25,26)
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n/an/a 3.20E+3n/an/an/an/an/an/a



Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM322166
PNG
(US10183931, Example 167)
Show SMILES Cc1cnc(nc1Nc1ccc2[nH]ncc2c1)-c1cccc(OCC(=O)NC2CCCC2)c1
Show InChI InChI=1S/C25H26N6O2/c1-16-13-26-25(30-24(16)29-20-9-10-22-18(11-20)14-27-31-22)17-5-4-8-21(12-17)33-15-23(32)28-19-6-2-3-7-19/h4-5,8-14,19H,2-3,6-7,15H2,1H3,(H,27,31)(H,28,32)(H,26,29,30)
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Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM322153
PNG
(2-(3-(4-((1H-indazol-5-yl)amino)-5-methylpyrimidin...)
Show SMILES Cc1cnc(nc1Nc1ccc2[nH]ncc2c1)-c1cccc(OCC(=O)NC2CC2)c1
Show InChI InChI=1S/C23H22N6O2/c1-14-11-24-23(28-22(14)27-18-7-8-20-16(9-18)12-25-29-20)15-3-2-4-19(10-15)31-13-21(30)26-17-5-6-17/h2-4,7-12,17H,5-6,13H2,1H3,(H,25,29)(H,26,30)(H,24,27,28)
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Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM322176
PNG
(US10183931, Example 176)
Show SMILES O=C(Nc1cccnc1)c1cccc(c1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C23H17N7O/c31-23(28-19-5-2-9-24-14-19)16-4-1-3-15(11-16)22-25-10-8-21(29-22)27-18-6-7-20-17(12-18)13-26-30-20/h1-14H,(H,26,30)(H,28,31)(H,25,27,29)
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Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM322169
PNG
(US10183931, Example 170)
Show SMILES Cc1cc(Nc2ccc3[nH]ncc3c2)nc(n1)-c1cccc(OCC(=O)NC2CC2)c1
Show InChI InChI=1S/C23H22N6O2/c1-14-9-21(26-18-7-8-20-16(10-18)12-24-29-20)28-23(25-14)15-3-2-4-19(11-15)31-13-22(30)27-17-5-6-17/h2-4,7-12,17H,5-6,13H2,1H3,(H,24,29)(H,27,30)(H,25,26,28)
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Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM322157
PNG
(2-(3-(4-((1H-indazol-5-yl)amino)pyrimidin-2-yl)phe...)
Show SMILES O=C(COc1cccc(c1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1)N1CCS(=O)(=O)CC1
Show InChI InChI=1S/C23H22N6O4S/c30-22(29-8-10-34(31,32)11-9-29)15-33-19-3-1-2-16(13-19)23-24-7-6-21(27-23)26-18-4-5-20-17(12-18)14-25-28-20/h1-7,12-14H,8-11,15H2,(H,25,28)(H,24,26,27)
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Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM322179
PNG
(US10183931, Example 178)
Show SMILES O=C(NN1CCOCC1)c1cccc(c1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C22H21N7O2/c30-22(28-29-8-10-31-11-9-29)16-3-1-2-15(12-16)21-23-7-6-20(26-21)25-18-4-5-19-17(13-18)14-24-27-19/h1-7,12-14H,8-11H2,(H,24,27)(H,28,30)(H,23,25,26)
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Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM322159
PNG
((R)-2-(3-(4-((1H-indazol-5-yl)amino)pyrimidin-2-yl...)
Show SMILES NC(=O)COc1cccc(c1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C19H16N6O2/c20-17(26)11-27-15-3-1-2-12(9-15)19-21-7-6-18(24-19)23-14-4-5-16-13(8-14)10-22-25-16/h1-10H,11H2,(H2,20,26)(H,22,25)(H,21,23,24)
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n/an/a 4.64E+3n/an/an/an/an/an/a



Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM322177
PNG
(US10183931, Example 177)
Show SMILES O=C(N1CCOCC1)c1cccc(c1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C22H20N6O2/c29-22(28-8-10-30-11-9-28)16-3-1-2-15(12-16)21-23-7-6-20(26-21)25-18-4-5-19-17(13-18)14-24-27-19/h1-7,12-14H,8-11H2,(H,24,27)(H,23,25,26)
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Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM322163
PNG
(US10183931, Example 164)
Show SMILES CC(C)NC(=O)COc1cccc(c1)-c1ncc(C)c(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C23H24N6O2/c1-14(2)26-21(30)13-31-19-6-4-5-16(10-19)23-24-11-15(3)22(28-23)27-18-7-8-20-17(9-18)12-25-29-20/h4-12,14H,13H2,1-3H3,(H,25,29)(H,26,30)(H,24,27,28)
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Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM322178
PNG
(N-(2-(3-(1-aminoethyl)phenyl)pyrimidin-4-yl)-1H-in...)
Show SMILES CC(N)c1cccc(c1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C19H18N6/c1-12(20)13-3-2-4-14(9-13)19-21-8-7-18(24-19)23-16-5-6-17-15(10-16)11-22-25-17/h2-12H,20H2,1H3,(H,22,25)(H,21,23,24)
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Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM322161
PNG
(US10183931, Example 163)
Show SMILES O=C(COc1cccc(c1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1)NC1CC1
Show InChI InChI=1S/C22H20N6O2/c29-21(26-16-4-5-16)13-30-18-3-1-2-14(11-18)22-23-9-8-20(27-22)25-17-6-7-19-15(10-17)12-24-28-19/h1-3,6-12,16H,4-5,13H2,(H,24,28)(H,26,29)(H,23,25,27)
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Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM322162
PNG
(2-(3-(4-((1H-indazol-5-yl)amino)-6-(piperazin-1-yl...)
Show SMILES CC(C)NC(=O)COc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)cc(n1)N1CCNCC1
Show InChI InChI=1S/C26H30N8O2/c1-17(2)29-25(35)16-36-21-5-3-4-18(13-21)26-31-23(14-24(32-26)34-10-8-27-9-11-34)30-20-6-7-22-19(12-20)15-28-33-22/h3-7,12-15,17,27H,8-11,16H2,1-2H3,(H,28,33)(H,29,35)(H,30,31,32)
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Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM322154
PNG
(2-(3-(4-((1H-indazol-5-yl)amino)-5-methylpyrimidin...)
Show SMILES Cc1cnc(nc1Nc1ccc2[nH]ncc2c1)-c1cccc(OCC(=O)NC2CCNCC2)c1
Show InChI InChI=1S/C25H27N7O2/c1-16-13-27-25(31-24(16)30-20-5-6-22-18(11-20)14-28-32-22)17-3-2-4-21(12-17)34-15-23(33)29-19-7-9-26-10-8-19/h2-6,11-14,19,26H,7-10,15H2,1H3,(H,28,32)(H,29,33)(H,27,30,31)
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Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM322170
PNG
(US10183931, Example 171)
Show SMILES Cc1nc(nc(Nc2ccc3[nH]ncc3c2)c1C)-c1cccc(OCC(=O)NC2CC2)c1
Show InChI InChI=1S/C24H24N6O2/c1-14-15(2)26-24(29-23(14)28-19-8-9-21-17(10-19)12-25-30-21)16-4-3-5-20(11-16)32-13-22(31)27-18-6-7-18/h3-5,8-12,18H,6-7,13H2,1-2H3,(H,25,30)(H,27,31)(H,26,28,29)
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n/an/a 7.50E+3n/an/an/an/an/an/a



Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM322172
PNG
(US10183931, Example 173)
Show SMILES Cc1nc(nc(Nc2ccc3[nH]ncc3c2)c1C)-c1cccc(OCC(=O)NC2CCC2)c1
Show InChI InChI=1S/C25H26N6O2/c1-15-16(2)27-25(30-24(15)29-20-9-10-22-18(11-20)13-26-31-22)17-5-3-8-21(12-17)33-14-23(32)28-19-6-4-7-19/h3,5,8-13,19H,4,6-7,14H2,1-2H3,(H,26,31)(H,28,32)(H,27,29,30)
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Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM322185
PNG
(US10183931, Example 180)
Show SMILES CN1CCC(CC1)NC(=O)c1cccc(c1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C24H25N7O/c1-31-11-8-19(9-12-31)28-24(32)17-4-2-3-16(13-17)23-25-10-7-22(29-23)27-20-5-6-21-18(14-20)15-26-30-21/h2-7,10,13-15,19H,8-9,11-12H2,1H3,(H,26,30)(H,28,32)(H,25,27,29)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM322171
PNG
(US10183931, Example 172)
Show SMILES CC(C)NC(=O)COc1cccc(c1)-c1nc(C)c(C)c(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C24H26N6O2/c1-14(2)26-22(31)13-32-20-7-5-6-17(11-20)24-27-16(4)15(3)23(29-24)28-19-8-9-21-18(10-19)12-25-30-21/h5-12,14H,13H2,1-4H3,(H,25,30)(H,26,31)(H,27,28,29)
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Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM322167
PNG
(US10183931, Example 168)
Show SMILES CC(C)NC(=O)COc1cccc(c1)-c1ncc(c(Nc2ccc3[nH]ncc3c2)n1)C(F)(F)F
Show InChI InChI=1S/C23H21F3N6O2/c1-13(2)29-20(33)12-34-17-5-3-4-14(9-17)21-27-11-18(23(24,25)26)22(31-21)30-16-6-7-19-15(8-16)10-28-32-19/h3-11,13H,12H2,1-2H3,(H,28,32)(H,29,33)(H,27,30,31)
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Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM322183
PNG
(3-(4-((1H-indazol-5-yl)amino)pyrimidin-2-yl)-N-(pi...)
Show SMILES O=C(NC1CCNCC1)c1cccc(c1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C23H23N7O/c31-23(28-18-6-9-24-10-7-18)16-3-1-2-15(12-16)22-25-11-8-21(29-22)27-19-4-5-20-17(13-19)14-26-30-20/h1-5,8,11-14,18,24H,6-7,9-10H2,(H,26,30)(H,28,31)(H,25,27,29)
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n/an/a 1.00E+4n/an/an/an/an/an/a



Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM322168
PNG
(US10183931, Example 169)
Show SMILES CC(C)NC(=O)COc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)cc(n1)C(F)(F)F
Show InChI InChI=1S/C23H21F3N6O2/c1-13(2)28-21(33)12-34-17-5-3-4-14(9-17)22-30-19(23(24,25)26)10-20(31-22)29-16-6-7-18-15(8-16)11-27-32-18/h3-11,13H,12H2,1-2H3,(H,27,32)(H,28,33)(H,29,30,31)
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Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM322187
PNG
(3-(4-((1H-indazol-5-yl)amino)pyrimidin-2-yl)-N-(1,...)
Show SMILES O=C(NC1CCS(=O)(=O)CC1)c1cccc(c1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C23H22N6O3S/c30-23(27-18-7-10-33(31,32)11-8-18)16-3-1-2-15(12-16)22-24-9-6-21(28-22)26-19-4-5-20-17(13-19)14-25-29-20/h1-6,9,12-14,18H,7-8,10-11H2,(H,25,29)(H,27,30)(H,24,26,28)
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Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM322177
PNG
(US10183931, Example 177)
Show SMILES O=C(N1CCOCC1)c1cccc(c1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C22H20N6O2/c29-22(28-8-10-30-11-9-28)16-3-1-2-15(12-16)21-23-7-6-20(26-21)25-18-4-5-19-17(13-18)14-24-27-19/h1-7,12-14H,8-11H2,(H,24,27)(H,23,25,26)
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Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM322168
PNG
(US10183931, Example 169)
Show SMILES CC(C)NC(=O)COc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)cc(n1)C(F)(F)F
Show InChI InChI=1S/C23H21F3N6O2/c1-13(2)28-21(33)12-34-17-5-3-4-14(9-17)22-30-19(23(24,25)26)10-20(31-22)29-16-6-7-18-15(8-16)11-27-32-18/h3-11,13H,12H2,1-2H3,(H,27,32)(H,28,33)(H,29,30,31)
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Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM322182
PNG
(N-(2-(3-(2-(isopropylamino)ethoxy)phenyl)pyrimidin...)
Show SMILES CC(C)NCCOc1cccc(c1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C22H24N6O/c1-15(2)23-10-11-29-19-5-3-4-16(13-19)22-24-9-8-21(27-22)26-18-6-7-20-17(12-18)14-25-28-20/h3-9,12-15,23H,10-11H2,1-2H3,(H,25,28)(H,24,26,27)
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Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM322155
PNG
(US10183931, SLx-2119)
Show SMILES CC(C)NC(=O)COc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2ccccc2n1
Show InChI InChI=1S/C26H24N6O2/c1-16(2)28-24(33)15-34-20-7-5-6-17(13-20)25-30-23-9-4-3-8-21(23)26(31-25)29-19-10-11-22-18(12-19)14-27-32-22/h3-14,16H,15H2,1-2H3,(H,27,32)(H,28,33)(H,29,30,31)
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n/an/a 1.31E+4n/an/an/an/an/an/a



Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM322159
PNG
((R)-2-(3-(4-((1H-indazol-5-yl)amino)pyrimidin-2-yl...)
Show SMILES NC(=O)COc1cccc(c1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C19H16N6O2/c20-17(26)11-27-15-3-1-2-12(9-15)19-21-7-6-18(24-19)23-14-4-5-16-13(8-14)10-22-25-16/h1-10H,11H2,(H2,20,26)(H,22,25)(H,21,23,24)
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n/an/a 2.25E+4n/an/an/an/an/an/a



Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM322153
PNG
(2-(3-(4-((1H-indazol-5-yl)amino)-5-methylpyrimidin...)
Show SMILES Cc1cnc(nc1Nc1ccc2[nH]ncc2c1)-c1cccc(OCC(=O)NC2CC2)c1
Show InChI InChI=1S/C23H22N6O2/c1-14-11-24-23(28-22(14)27-18-7-8-20-16(9-18)12-25-29-20)15-3-2-4-19(10-15)31-13-21(30)26-17-5-6-17/h2-4,7-12,17H,5-6,13H2,1H3,(H,25,29)(H,26,30)(H,24,27,28)
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n/an/a 5.35E+4n/an/an/an/an/an/a



Kadmon Corporation, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...


US Patent US10183931 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%