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Patent code US10183944

Compile Data Set for Download or QSAR

Found 614 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM322692
PNG
(6-(4-((2-(azepan-1-yl)-5-oxo-5,6- dihydropyrimido[...)
Show SMILES OC(=O)C1CC11CCN(CC1)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCCCCC2)cc1
Show InChI InChI=1S/C26H31N7O3/c34-23-21-20(16-27-31-23)29-25(33-11-3-1-2-4-12-33)30-22(21)28-17-5-7-18(8-6-17)32-13-9-26(10-14-32)15-19(26)24(35)36/h5-8,16,19H,1-4,9-15H2,(H,31,34)(H,35,36)(H,28,29,30)
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Asana BioSciences, LLC

US Patent


Assay Description
2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM322710
PNG
(2-(1-(4-((2-(azepan-1-yl)-5-oxo-5,6- dihydropyrimi...)
Show SMILES O=c1[nH]ncc2nc(nc(Nc3ccc(cc3)N3CCC(CC#N)CC3)c12)N1CCCCCC1
Show InChI InChI=1S/C25H30N8O/c26-12-9-18-10-15-32(16-11-18)20-7-5-19(6-8-20)28-23-22-21(17-27-31-24(22)34)29-25(30-23)33-13-3-1-2-4-14-33/h5-8,17-18H,1-4,9-11,13-16H2,(H,31,34)(H,28,29,30)
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Asana BioSciences, LLC

US Patent


Assay Description
Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM322714
PNG
(2-(azepan-1-yl)-4-((4-((4-(2-hydroxy-2- methylprop...)
Show SMILES CC(C)(O)C(=O)N1CCN(Cc2ccc(Nc3nc(nc4cn[nH]c(=O)c34)N3CCCCCC3)cc2)CC1
Show InChI InChI=1S/C27H36N8O3/c1-27(2,38)25(37)34-15-13-33(14-16-34)18-19-7-9-20(10-8-19)29-23-22-21(17-28-32-24(22)36)30-26(31-23)35-11-5-3-4-6-12-35/h7-10,17,38H,3-6,11-16,18H2,1-2H3,(H,32,36)(H,29,30,31)
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Asana BioSciences, LLC

US Patent


Assay Description
Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM322718
PNG
(2-(1-(4-((2-(azocan-1-yl)-5-oxo-5,6- dihydropyrimi...)
Show SMILES OC(=O)CC1CCN(CC1)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCCCCCC2)cc1
Show InChI InChI=1S/C26H33N7O3/c34-22(35)16-18-10-14-32(15-11-18)20-8-6-19(7-9-20)28-24-23-21(17-27-31-25(23)36)29-26(30-24)33-12-4-2-1-3-5-13-33/h6-9,17-18H,1-5,10-16H2,(H,31,36)(H,34,35)(H,28,29,30)
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Asana BioSciences, LLC

US Patent


Assay Description
2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM322734
PNG
(2-(azepan-1-yl)-4-((4-(piperazine-1- carbonyl)phen...)
Show SMILES O=C(N1CCNCC1)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCCCCC2)cc1
Show InChI InChI=1S/C23H28N8O2/c32-21-19-18(15-25-29-21)27-23(31-11-3-1-2-4-12-31)28-20(19)26-17-7-5-16(6-8-17)22(33)30-13-9-24-10-14-30/h5-8,15,24H,1-4,9-14H2,(H,29,32)(H,26,27,28)
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Asana BioSciences, LLC

US Patent


Assay Description
Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM322738
PNG
(2-(1-(5-((2-(azepan-1-yl)-5-oxo-5,6- dihydropyrimi...)
Show SMILES OC(=O)CC1CCN(CC1)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCCCCC2)cn1
Show InChI InChI=1S/C24H30N8O3/c33-20(34)13-16-7-11-31(12-8-16)19-6-5-17(14-25-19)27-22-21-18(15-26-30-23(21)35)28-24(29-22)32-9-3-1-2-4-10-32/h5-6,14-16H,1-4,7-13H2,(H,30,35)(H,33,34)(H,27,28,29)
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Asana BioSciences, LLC

US Patent


Assay Description
2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM322739
PNG
(2-(1-(4-((2-(azepan-1-yl)-5-oxo-5,6- dihydropyrimi...)
Show SMILES OCCNC(=O)CC1CCN(CC1)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCCCCC2)cc1
Show InChI InChI=1S/C27H36N8O3/c36-16-11-28-23(37)17-19-9-14-34(15-10-19)21-7-5-20(6-8-21)30-25-24-22(18-29-33-26(24)38)31-27(32-25)35-12-3-1-2-4-13-35/h5-8,18-19,36H,1-4,9-17H2,(H,28,37)(H,33,38)(H,30,31,32)
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Asana BioSciences, LLC

US Patent


Assay Description
2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM322744
PNG
(2-(1-(5-((2-(4-(cyanomethyl)piperidin-1- yl)-5-oxo...)
Show SMILES O=c1[nH]ncc2nc(nc(Nc3ccc(nc3)N3CCC(C[N+]#[C-])CC3)c12)N1CCC(CC#N)CC1
Show InChI InChI=1S/C25H28N10O/c1-27-14-18-7-10-34(11-8-18)21-3-2-19(15-28-21)30-23-22-20(16-29-33-24(22)36)31-25(32-23)35-12-5-17(4-9-26)6-13-35/h2-3,15-18H,4-8,10-14H2,(H,33,36)(H,30,31,32)
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Asana BioSciences, LLC

US Patent


Assay Description
2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM322761
PNG
(2-(1-(4-((2-(azepan-1-yl)-5-oxo-5,6- dihydropyrimi...)
Show SMILES OC(=O)C1CC1C1CCN(CC1)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCCCCC2)cc1
Show InChI InChI=1S/C27H33N7O3/c35-25-23-22(16-28-32-25)30-27(34-11-3-1-2-4-12-34)31-24(23)29-18-5-7-19(8-6-18)33-13-9-17(10-14-33)20-15-21(20)26(36)37/h5-8,16-17,20-21H,1-4,9-15H2,(H,32,35)(H,36,37)(H,29,30,31)
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Asana BioSciences, LLC

US Patent


Assay Description
2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM322788
PNG
(6-(2-(4-((2-(azepan-1-yl)-5-oxo-5,6- dihydropyrimi...)
Show SMILES OC(=O)C1CC11CCN(CCOc2ccc(Nc3nc(nc4cn[nH]c(=O)c34)N3CCCCCC3)cc2)CC1
Show InChI InChI=1S/C28H35N7O4/c36-25-23-22(18-29-33-25)31-27(35-11-3-1-2-4-12-35)32-24(23)30-19-5-7-20(8-6-19)39-16-15-34-13-9-28(10-14-34)17-21(28)26(37)38/h5-8,18,21H,1-4,9-17H2,(H,33,36)(H,37,38)(H,30,31,32)
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Asana BioSciences, LLC

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Assay Description
Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM322792
PNG
(2-(4-(4-((2-(4-(cyanomethyl)piperidin-1- yl)-5-oxo...)
Show SMILES OC(=O)CN1CCN(CC1)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCC(CC#N)CC2)cc1
Show InChI InChI=1S/C25H29N9O3/c26-8-5-17-6-9-34(10-7-17)25-29-20-15-27-31-24(37)22(20)23(30-25)28-18-1-3-19(4-2-18)33-13-11-32(12-14-33)16-21(35)36/h1-4,15,17H,5-7,9-14,16H2,(H,31,37)(H,35,36)(H,28,29,30)
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Asana BioSciences, LLC

US Patent


Assay Description
2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM322794
PNG
(4-((4-(2-(1,4-diazepan-1-yl)ethoxy) phenyl)amino)-...)
Show SMILES O=c1[nH]ncc2nc(nc(Nc3ccc(OCCN4CCCNCC4)cc3)c12)N1CCCCCC1
Show InChI InChI=1S/C25H34N8O2/c34-24-22-21(18-27-31-24)29-25(33-13-3-1-2-4-14-33)30-23(22)28-19-6-8-20(9-7-19)35-17-16-32-12-5-10-26-11-15-32/h6-9,18,26H,1-5,10-17H2,(H,31,34)(H,28,29,30)
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Asana BioSciences, LLC

US Patent


Assay Description
Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM322797
PNG
(2-(azepan-1-yl)-4-((4-(2-(dimethylamino) ethoxy)ph...)
Show SMILES CN(C)CCOc1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCCCCC2)cc1
Show InChI InChI=1S/C22H29N7O2/c1-28(2)13-14-31-17-9-7-16(8-10-17)24-20-19-18(15-23-27-21(19)30)25-22(26-20)29-11-5-3-4-6-12-29/h7-10,15H,3-6,11-14H2,1-2H3,(H,27,30)(H,24,25,26)
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Asana BioSciences, LLC

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Assay Description
Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM322800
PNG
(6-(4-((2-(cyclohexyl(methyl)amino)-5- oxo-5,6-dihy...)
Show SMILES CN(C1CCCCC1)c1nc(Nc2ccc(cc2)N2CCC3(CC3C(O)=O)CC2)c2c(cn[nH]c2=O)n1
Show InChI InChI=1S/C27H33N7O3/c1-33(18-5-3-2-4-6-18)26-30-21-16-28-32-24(35)22(21)23(31-26)29-17-7-9-19(10-8-17)34-13-11-27(12-14-34)15-20(27)25(36)37/h7-10,16,18,20H,2-6,11-15H2,1H3,(H,32,35)(H,36,37)(H,29,30,31)
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Asana BioSciences, LLC

US Patent


Assay Description
Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM322823
PNG
(2-(1-(5-oxo-4-((4-(piperazin-1-yl)phenyl) amino)-5...)
Show SMILES NC(=O)c1c(Nc2ccc(cc2)N2CCNCC2)nc(nc1C=N)N1CCC(CC#N)CC1
Show InChI InChI=1S/C23H29N9O/c24-8-5-16-6-11-32(12-7-16)23-29-19(15-25)20(21(26)33)22(30-23)28-17-1-3-18(4-2-17)31-13-9-27-10-14-31/h1-4,15-16,25,27H,5-7,9-14H2,(H2,26,33)(H,28,29,30)
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Asana BioSciences, LLC

US Patent


Assay Description
2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM322828
PNG
(2-(azepan-1-yl)-4-((4-(2-(piperazin-1- yl)ethyl)ph...)
Show SMILES NC(=O)c1c(Nc2ccc(CCN3CCNCC3)cc2)nc(nc1C=N)N1CCCCCC1
Show InChI InChI=1S/C24H34N8O/c25-17-20-21(22(26)33)23(30-24(29-20)32-12-3-1-2-4-13-32)28-19-7-5-18(6-8-19)9-14-31-15-10-27-11-16-31/h5-8,17,25,27H,1-4,9-16H2,(H2,26,33)(H,28,29,30)
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Asana BioSciences, LLC

US Patent


Assay Description
Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM322832
PNG
(2-(azepan-1-yl)-4-((4-(4-(hydroxymethyl) piperidin...)
Show SMILES NC(=O)c1c(Nc2ccc(cc2)N2CCC(CO)CC2)nc(nc1C=N)N1CCCCCC1
Show InChI InChI=1S/C24H33N7O2/c25-15-20-21(22(26)33)23(29-24(28-20)31-11-3-1-2-4-12-31)27-18-5-7-19(8-6-18)30-13-9-17(16-32)10-14-30/h5-8,15,17,25,32H,1-4,9-14,16H2,(H2,26,33)(H,27,28,29)
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Asana BioSciences, LLC

US Patent


Assay Description
Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM322874
PNG
(4-((4-(4-((2H-tetrazol-5-yl)methyl) piperidin-1-yl...)
Show SMILES O=c1[nH]ncc2nc(nc(Nc3ccc(cc3)N3CCC(Cc4nn[nH]n4)CC3)c12)N1CCCCCC1
Show InChI InChI=1S/C25H31N11O/c37-24-22-20(16-26-32-24)28-25(36-11-3-1-2-4-12-36)29-23(22)27-18-5-7-19(8-6-18)35-13-9-17(10-14-35)15-21-30-33-34-31-21/h5-8,16-17H,1-4,9-15H2,(H,32,37)(H,27,28,29)(H,30,31,33,34)
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Asana BioSciences, LLC

US Patent


Assay Description
2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM322886
PNG
(2-(1-(4-((4-(4-(2-methoxyethyl) piperazin-1-yl)phe...)
Show SMILES COCCN1CCN(CC1)c1ccc(Nc2nc(nc(C=N)c2C(N)=O)N2CCC(CC#N)CC2)cc1
Show InChI InChI=1S/C26H35N9O2/c1-37-17-16-33-12-14-34(15-13-33)21-4-2-20(3-5-21)30-25-23(24(29)36)22(18-28)31-26(32-25)35-10-7-19(6-9-27)8-11-35/h2-5,18-19,28H,6-8,10-17H2,1H3,(H2,29,36)(H,30,31,32)
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Asana BioSciences, LLC

US Patent


Assay Description
2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM322894
PNG
(2-(1-(4-((4-(4-(2-hydroxyethyl)-1,4- diazepan-1-yl...)
Show SMILES OCCN1CCCN(CC1)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCC(CC#N)CC2)cc1
Show InChI InChI=1S/C26H33N9O2/c27-9-6-19-7-12-35(13-8-19)26-30-22-18-28-32-25(37)23(22)24(31-26)29-20-2-4-21(5-3-20)34-11-1-10-33(14-15-34)16-17-36/h2-5,18-19,36H,1,6-8,10-17H2,(H,32,37)(H,29,30,31)
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Asana BioSciences, LLC

US Patent


Assay Description
2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM322894
PNG
(2-(1-(4-((4-(4-(2-hydroxyethyl)-1,4- diazepan-1-yl...)
Show SMILES OCCN1CCCN(CC1)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCC(CC#N)CC2)cc1
Show InChI InChI=1S/C26H33N9O2/c27-9-6-19-7-12-35(13-8-19)26-30-22-18-28-32-25(37)23(22)24(31-26)29-20-2-4-21(5-3-20)34-11-1-10-33(14-15-34)16-17-36/h2-5,18-19,36H,1,6-8,10-17H2,(H,32,37)(H,29,30,31)
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Asana BioSciences, LLC

US Patent


Assay Description
Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM322903
PNG
(2-(azepan-1-yl)-4-((4-(4-(2,3- dihydroxypropyl)pip...)
Show SMILES OCC(O)CN1CCN(CC1)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCCCCC2)cc1
Show InChI InChI=1S/C25H34N8O3/c34-17-20(35)16-31-11-13-32(14-12-31)19-7-5-18(6-8-19)27-23-22-21(15-26-30-24(22)36)28-25(29-23)33-9-3-1-2-4-10-33/h5-8,15,20,34-35H,1-4,9-14,16-17H2,(H,30,36)(H,27,28,29)
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Asana BioSciences, LLC

US Patent


Assay Description
2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM322905
PNG
(2-(azepan-1-yl)-4-((4-(4-(2-fluoroethyl) piperazin...)
Show SMILES FCCN1CCN(CC1)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCCCCC2)cc1
Show InChI InChI=1S/C24H31FN8O/c25-9-12-31-13-15-32(16-14-31)19-7-5-18(6-8-19)27-22-21-20(17-26-30-23(21)34)28-24(29-22)33-10-3-1-2-4-11-33/h5-8,17H,1-4,9-16H2,(H,30,34)(H,27,28,29)
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Asana BioSciences, LLC

US Patent


Assay Description
2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM322938
PNG
(2-(azepan-1-yl)-4-((4-(3-hydroxypropyl) phenyl)ami...)
Show SMILES OCCCc1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCCCCC2)cc1
Show InChI InChI=1S/C21H26N6O2/c28-13-5-6-15-7-9-16(10-8-15)23-19-18-17(14-22-26-20(18)29)24-21(25-19)27-11-3-1-2-4-12-27/h7-10,14,28H,1-6,11-13H2,(H,26,29)(H,23,24,25)
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Asana BioSciences, LLC

US Patent


Assay Description
Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM322839
PNG
(2-(azepan-1-yl)-4-((4-(2-(4- ethylpiperazin-1-yl)e...)
Show SMILES CCN1CCN(CCc2ccc(Nc3nc(nc(C=N)c3C(N)=O)N3CCCCCC3)cc2)CC1
Show InChI InChI=1S/C26H38N8O/c1-2-32-15-17-33(18-16-32)14-11-20-7-9-21(10-8-20)29-25-23(24(28)35)22(19-27)30-26(31-25)34-12-5-3-4-6-13-34/h7-10,19,27H,2-6,11-18H2,1H3,(H2,28,35)(H,29,30,31)
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Asana BioSciences, LLC

US Patent


Assay Description
2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM322840
PNG
(2-(azepan-1-yl)-4-((4-(2-(4-hydroxy-4- methylpiper...)
Show SMILES CC1(O)CCN(CCc2ccc(Nc3nc(nc(C=N)c3C(N)=O)N3CCCCCC3)cc2)CC1
Show InChI InChI=1S/C26H37N7O2/c1-26(35)11-16-32(17-12-26)15-10-19-6-8-20(9-7-19)29-24-22(23(28)34)21(18-27)30-25(31-24)33-13-4-2-3-5-14-33/h6-9,18,27,35H,2-5,10-17H2,1H3,(H2,28,34)(H,29,30,31)
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Asana BioSciences, LLC

US Patent


Assay Description
Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM322849
PNG
((phosphonooxy)methyl 6-(4-((2-(azepan- 1-yl)-5-oxo...)
Show SMILES NC(=O)c1c(Nc2ccc(cc2)N2CCC3(CC3C(=O)OCO)CC2)nc(nc1C=N)N1CCCCCC1
Show InChI InChI=1S/C27H35N7O4/c28-16-21-22(23(29)36)24(32-26(31-21)34-11-3-1-2-4-12-34)30-18-5-7-19(8-6-18)33-13-9-27(10-14-33)15-20(27)25(37)38-17-35/h5-8,16,20,28,35H,1-4,9-15,17H2,(H2,29,36)(H,30,31,32)
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Asana BioSciences, LLC

US Patent


Assay Description
2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM322857
PNG
(4-((4-(2H-tetrazol-5-yl)phenyl)amino)-2- (azepan-1...)
Show SMILES O=c1[nH]ncc2nc(nc(Nc3ccc(cc3)-c3nn[nH]n3)c12)N1CCCCCC1
Show InChI InChI=1S/C19H20N10O/c30-18-15-14(11-20-26-18)22-19(29-9-3-1-2-4-10-29)23-17(15)21-13-7-5-12(6-8-13)16-24-27-28-25-16/h5-8,11H,1-4,9-10H2,(H,26,30)(H,21,22,23)(H,24,25,27,28)
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Asana BioSciences, LLC

US Patent


Assay Description
Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM322882
PNG
(4-((6-(4-((2H-tetrazol-5-yl)methyl) piperidin-1-yl...)
Show SMILES NC(=O)c1c(Nc2ccc(nc2)N2CCC(CC(=N)N=N)CC2)nc(nc1C=N)N1CCCCCC1
Show InChI InChI=1S/C24H33N11O/c25-14-18-21(22(27)36)23(32-24(31-18)35-9-3-1-2-4-10-35)30-17-5-6-20(29-15-17)34-11-7-16(8-12-34)13-19(26)33-28/h5-6,14-16,25-26,28H,1-4,7-13H2,(H2,27,36)(H,30,31,32)
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Asana BioSciences, LLC

US Patent


Assay Description
Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM322904
PNG
(2-(1-(4-((4-(4-(2,3-dihydroxypropyl) piperazin-1-y...)
Show SMILES NC(=O)c1c(Nc2ccc(cc2)N2CCN(CC(O)CO)CC2)nc(nc1C=N)N1CCC(CC#N)CC1
Show InChI InChI=1S/C26H35N9O3/c27-8-5-18-6-9-35(10-7-18)26-31-22(15-28)23(24(29)38)25(32-26)30-19-1-3-20(4-2-19)34-13-11-33(12-14-34)16-21(37)17-36/h1-4,15,18,21,28,36-37H,5-7,9-14,16-17H2,(H2,29,38)(H,30,31,32)
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Asana BioSciences, LLC

US Patent


Assay Description
Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM322914
PNG
(2-(1-(4-((4-(3-(hydroxymethyl)piperidin- 1-yl)phen...)
Show SMILES OCC1CCCN(C1)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCC(CC#N)CC2)cc1
Show InChI InChI=1S/C25H30N8O2/c26-10-7-17-8-12-32(13-9-17)25-29-21-14-27-31-24(35)22(21)23(30-25)28-19-3-5-20(6-4-19)33-11-1-2-18(15-33)16-34/h3-6,14,17-18,34H,1-2,7-9,11-13,15-16H2,(H,31,35)(H,28,29,30)
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Asana BioSciences, LLC

US Patent


Assay Description
2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM322914
PNG
(2-(1-(4-((4-(3-(hydroxymethyl)piperidin- 1-yl)phen...)
Show SMILES OCC1CCCN(C1)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCC(CC#N)CC2)cc1
Show InChI InChI=1S/C25H30N8O2/c26-10-7-17-8-12-32(13-9-17)25-29-21-14-27-31-24(35)22(21)23(30-25)28-19-3-5-20(6-4-19)33-11-1-2-18(15-33)16-34/h3-6,14,17-18,34H,1-2,7-9,11-13,15-16H2,(H,31,35)(H,28,29,30)
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Asana BioSciences, LLC

US Patent


Assay Description
Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM322922
PNG
(2-(azepan-1-yl)-4-((4-(piperidin-4-yloxy) phenyl)a...)
Show SMILES N=[Cl]1CCC(CC1)Oc1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCCCCC2)cc1
Show InChI InChI=1S/C23H29ClN7O2/c25-24-11-9-18(10-12-24)33-17-7-5-16(6-8-17)27-21-20-19(15-26-30-22(20)32)28-23(29-21)31-13-3-1-2-4-14-31/h5-8,15,18,25H,1-4,9-14H2,(H,30,32)(H,27,28,29)
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Asana BioSciences, LLC

US Patent


Assay Description
2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM322946
PNG
(2-(4-((2-(azepan-1-yl)-5-oxo-5,6- dihydropyrimido[...)
Show SMILES CC(C)(Oc1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCCCCC2)cc1)C(O)=O
Show InChI InChI=1S/C22H26N6O4/c1-22(2,20(30)31)32-15-9-7-14(8-10-15)24-18-17-16(13-23-27-19(17)29)25-21(26-18)28-11-5-3-4-6-12-28/h7-10,13H,3-6,11-12H2,1-2H3,(H,27,29)(H,30,31)(H,24,25,26)
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Asana BioSciences, LLC

US Patent


Assay Description
Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM322635
PNG
(4-(4-(4-ethylpiperazin-1-yl) phenylamino)-2-phenyl...)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)-c2ccccc2)cc1
Show InChI InChI=1S/C24H25N7O/c1-2-30-12-14-31(15-13-30)19-10-8-18(9-11-19)26-23-21-20(16-25-29-24(21)32)27-22(28-23)17-6-4-3-5-7-17/h3-11,16H,2,12-15H2,1H3,(H,29,32)(H,26,27,28)
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Asana BioSciences, LLC

US Patent


Assay Description
2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM322655
PNG
(4-(4-(piperazin-1-ylmethyl) phenylamino)-2-(thioph...)
Show SMILES O=c1[nH]ncc2nc(nc(Nc3ccc(CN4CCNCC4)cc3)c12)-c1ccsc1
Show InChI InChI=1S/C21H21N7OS/c29-21-18-17(11-23-27-21)25-19(15-5-10-30-13-15)26-20(18)24-16-3-1-14(2-4-16)12-28-8-6-22-7-9-28/h1-5,10-11,13,22H,6-9,12H2,(H,27,29)(H,24,25,26)
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Asana BioSciences, LLC

US Patent


Assay Description
2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM322692
PNG
(6-(4-((2-(azepan-1-yl)-5-oxo-5,6- dihydropyrimido[...)
Show SMILES OC(=O)C1CC11CCN(CC1)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCCCCC2)cc1
Show InChI InChI=1S/C26H31N7O3/c34-23-21-20(16-27-31-23)29-25(33-11-3-1-2-4-12-33)30-22(21)28-17-5-7-18(8-6-17)32-13-9-26(10-14-32)15-19(26)24(35)36/h5-8,16,19H,1-4,9-15H2,(H,31,34)(H,35,36)(H,28,29,30)
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Asana BioSciences, LLC

US Patent


Assay Description
Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM322699
PNG
(2-(1-(4-((2-(azepan-1-yl)-5-oxo-5,6- dihydropyrimi...)
Show SMILES OC(=O)CC1CCN(CC1)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCCCCC2)cc1
Show InChI InChI=1S/C25H31N7O3/c33-21(34)15-17-9-13-31(14-10-17)19-7-5-18(6-8-19)27-23-22-20(16-26-30-24(22)35)28-25(29-23)32-11-3-1-2-4-12-32/h5-8,16-17H,1-4,9-15H2,(H,30,35)(H,33,34)(H,27,28,29)
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Asana BioSciences, LLC

US Patent


Assay Description
2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM322715
PNG
(2-(azepan-1-yl)-4-((4-((4-methylpiperazin- 1-yl)me...)
Show SMILES CN1CCN(Cc2ccc(Nc3nc(nc4cn[nH]c(=O)c34)N3CCCCCC3)cc2)CC1
Show InChI InChI=1S/C24H32N8O/c1-30-12-14-31(15-13-30)17-18-6-8-19(9-7-18)26-22-21-20(16-25-29-23(21)33)27-24(28-22)32-10-4-2-3-5-11-32/h6-9,16H,2-5,10-15,17H2,1H3,(H,29,33)(H,26,27,28)
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Asana BioSciences, LLC

US Patent


Assay Description
Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM322733
PNG
(2-(1-(5-((2-(4-(cyanomethyl)piperidin-1- yl)-5-oxo...)
Show SMILES O=c1[nH]ncc2nc(nc(Nc3ccc(nc3)N3CCC(CC#N)CC3)c12)N1CCC(C[N+]#[C-])CC1
Show InChI InChI=1S/C25H28N10O/c1-27-14-18-7-12-35(13-8-18)25-31-20-16-29-33-24(36)22(20)23(32-25)30-19-2-3-21(28-15-19)34-10-5-17(4-9-26)6-11-34/h2-3,15-18H,4-8,10-14H2,(H,33,36)(H,30,31,32)
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Asana BioSciences, LLC

US Patent


Assay Description
Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM322753
PNG
(2-((1S,4S)-4-(4-((2-(azepan-1-yl)-5-oxo- 5,6-dihyd...)
Show SMILES OC(=O)C[C@H]1CC[C@H](CC1)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCCCCC2)cc1
Show InChI InChI=1S/C26H32N6O3/c33-22(34)15-17-5-7-18(8-6-17)19-9-11-20(12-10-19)28-24-23-21(16-27-31-25(23)35)29-26(30-24)32-13-3-1-2-4-14-32/h9-12,16-18H,1-8,13-15H2,(H,31,35)(H,33,34)(H,28,29,30)/t17-,18+
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Asana BioSciences, LLC

US Patent


Assay Description
Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM322760
PNG
(3-(1-(4-((2-(azepan-1-yl)-5-oxo-5,6- dihydropyrimi...)
Show SMILES OC(=O)CCC1CCN(CC1)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCCCCC2)cc1
Show InChI InChI=1S/C26H33N7O3/c34-22(35)10-5-18-11-15-32(16-12-18)20-8-6-19(7-9-20)28-24-23-21(17-27-31-25(23)36)29-26(30-24)33-13-3-1-2-4-14-33/h6-9,17-18H,1-5,10-16H2,(H,31,36)(H,34,35)(H,28,29,30)
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Asana BioSciences, LLC

US Patent


Assay Description
Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM322771
PNG
(6-(4-((2-(azocan-1-yl)-5-oxo-5,6- dihydropyrimido[...)
Show SMILES OC(=O)C1CC11CCN(CC1)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCCCCCC2)cc1
Show InChI InChI=1S/C27H33N7O3/c35-24-22-21(17-28-32-24)30-26(34-12-4-2-1-3-5-13-34)31-23(22)29-18-6-8-19(9-7-18)33-14-10-27(11-15-33)16-20(27)25(36)37/h6-9,17,20H,1-5,10-16H2,(H,32,35)(H,36,37)(H,29,30,31)
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Asana BioSciences, LLC

US Patent


Assay Description
Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM322805
PNG
(2-(azepan-1-yl)-4-((4-(4-ethyl-3- oxopiperazin-1-y...)
Show SMILES CCN1CCN(CC1=O)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCCCCC2)cc1
Show InChI InChI=1S/C24H30N8O2/c1-2-30-13-14-32(16-20(30)33)18-9-7-17(8-10-18)26-22-21-19(15-25-29-23(21)34)27-24(28-22)31-11-5-3-4-6-12-31/h7-10,15H,2-6,11-14,16H2,1H3,(H,29,34)(H,26,27,28)
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Asana BioSciences, LLC

US Patent


Assay Description
2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM322805
PNG
(2-(azepan-1-yl)-4-((4-(4-ethyl-3- oxopiperazin-1-y...)
Show SMILES CCN1CCN(CC1=O)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCCCCC2)cc1
Show InChI InChI=1S/C24H30N8O2/c1-2-30-13-14-32(16-20(30)33)18-9-7-17(8-10-18)26-22-21-19(15-25-29-23(21)34)27-24(28-22)31-11-5-3-4-6-12-31/h7-10,15H,2-6,11-14,16H2,1H3,(H,29,34)(H,26,27,28)
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Asana BioSciences, LLC

US Patent


Assay Description
Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM322809
PNG
(2-(azepan-1-yl)-4-((4-(3-(4- hydroxypiperidin-1-yl...)
Show SMILES NC(=O)c1c(Nc2ccc(CCCN3CCC(O)CC3)cc2)nc(nc1C=N)N1CCCCCC1
Show InChI InChI=1S/C26H37N7O2/c27-18-22-23(24(28)35)25(31-26(30-22)33-14-3-1-2-4-15-33)29-20-9-7-19(8-10-20)6-5-13-32-16-11-21(34)12-17-32/h7-10,18,21,27,34H,1-6,11-17H2,(H2,28,35)(H,29,30,31)
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Asana BioSciences, LLC

US Patent


Assay Description
Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM322810
PNG
(2-(azepan-1-yl)-4-((4-(4-ethylpiperazin-1- yl)phen...)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCCCCC2)cc1
Show InChI InChI=1S/C24H32N8O/c1-2-30-13-15-31(16-14-30)19-9-7-18(8-10-19)26-22-21-20(17-25-29-23(21)33)27-24(28-22)32-11-5-3-4-6-12-32/h7-10,17H,2-6,11-16H2,1H3,(H,29,33)(H,26,27,28)
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Asana BioSciences, LLC

US Patent


Assay Description
2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM322820
PNG
(2-(azepan-1-yl)-4-((4-(4-(2- hydroxyethyl)piperazi...)
Show SMILES NC(=O)c1c(Nc2ccc(cc2)N2CCN(CCO)CC2)nc(nc1C=N)N1CCCCCC1
Show InChI InChI=1S/C24H34N8O2/c25-17-20-21(22(26)34)23(29-24(28-20)32-9-3-1-2-4-10-32)27-18-5-7-19(8-6-18)31-13-11-30(12-14-31)15-16-33/h5-8,17,25,33H,1-4,9-16H2,(H2,26,34)(H,27,28,29)
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Asana BioSciences, LLC

US Patent


Assay Description
2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM322822
PNG
(2-(azepan-1-yl)-4-((4-(piperazin-1-yl) phenyl)amin...)
Show SMILES NC(=O)c1c(Nc2ccc(cc2)N2CCNCC2)nc(nc1C=N)N1CCCCCC1
Show InChI InChI=1S/C22H30N8O/c23-15-18-19(20(24)31)21(28-22(27-18)30-11-3-1-2-4-12-30)26-16-5-7-17(8-6-16)29-13-9-25-10-14-29/h5-8,15,23,25H,1-4,9-14H2,(H2,24,31)(H,26,27,28)
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Asana BioSciences, LLC

US Patent


Assay Description
2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM322825
PNG
(2-(azepan-1-yl)-4-((4-(4-(2-hydroxyethyl) piperidi...)
Show SMILES NC(=O)c1c(Nc2ccc(cc2)N2CCC(CCO)CC2)nc(nc1C=N)N1CCCCCC1
Show InChI InChI=1S/C25H35N7O2/c26-17-21-22(23(27)34)24(30-25(29-21)32-12-3-1-2-4-13-32)28-19-5-7-20(8-6-19)31-14-9-18(10-15-31)11-16-33/h5-8,17-18,26,33H,1-4,9-16H2,(H2,27,34)(H,28,29,30)
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Asana BioSciences, LLC

US Patent


Assay Description
2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%