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Patent code US10188615

Compile Data Set for Download or QSAR
Found 195 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323451
PNG
(3-((3-(3-Aminopropyl)Phenoxy)Methyl)Pentan-3-Ol | ...)
Show SMILES CCC(O)(CC)COc1cccc(CCCN)c1
Show InChI InChI=1S/C15H25NO2/c1-3-15(17,4-2)12-18-14-9-5-7-13(11-14)8-6-10-16/h5,7,9,11,17H,3-4,6,8,10,12,16H2,1-2H3
PDB

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ACUCELA INC.

US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323490
PNG
((1,2-Trans)-2-((3-((R)-3-Amino-1-Hydroxypropyl)Phe...)
Show SMILES CC(=O)O[C@@H]1CCCC[C@H]1COc1cccc(c1)[C@H](O)CCN
Show InChI InChI=1S/C18H27NO4/c1-13(20)23-18-8-3-2-5-15(18)12-22-16-7-4-6-14(11-16)17(21)9-10-19/h4,6-7,11,15,17-18,21H,2-3,5,8-10,12,19H2,1H3/t15-,17+,18+/m0/s1
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ACUCELA INC.

US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323467
PNG
(2-(3-(Pentyloxy)Phenoxy)Ethanamine | US10188615, E...)
Show SMILES CCCCCOc1cccc(OCCN)c1
Show InChI InChI=1S/C13H21NO2/c1-2-3-4-9-15-12-6-5-7-13(11-12)16-10-8-14/h5-7,11H,2-4,8-10,14H2,1H3
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ACUCELA INC.

US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323480
PNG
(3-(3-(Cyclohexylmethoxy)Phenyl)-3-Hydroxypropanimi...)
Show SMILES NC(=N)CC(O)c1cccc(OCC2CCCCC2)c1
Show InChI InChI=1S/C16H24N2O2/c17-16(18)10-15(19)13-7-4-8-14(9-13)20-11-12-5-2-1-3-6-12/h4,7-9,12,15,19H,1-3,5-6,10-11H2,(H3,17,18)
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ACUCELA INC.

US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323486
PNG
(3-Amino-1-(3-(2-Hydroxy-2-Phenylethoxy)Phenyl)Prop...)
Show SMILES NCCC(O)c1cccc(OCC(O)c2ccccc2)c1
Show InChI InChI=1S/C17H21NO3/c18-10-9-16(19)14-7-4-8-15(11-14)21-12-17(20)13-5-2-1-3-6-13/h1-8,11,16-17,19-20H,9-10,12,18H2
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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323493
PNG
((R)-3-(3-Amino-1-Hydroxypropyl)-5-(Cyclohexylmetho...)
Show SMILES NCC[C@@H](O)c1cc(O)cc(OCC2CCCCC2)c1
Show InChI InChI=1S/C16H25NO3/c17-7-6-16(19)13-8-14(18)10-15(9-13)20-11-12-4-2-1-3-5-12/h8-10,12,16,18-19H,1-7,11,17H2/t16-/m1/s1
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ACUCELA INC.

US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323437
PNG
(3-(3-(Cyclohexylmethoxy)Phenyl)Propan-1-Amine | US...)
Show SMILES NCCCc1cccc(OCC2CCCCC2)c1
Show InChI InChI=1S/C16H25NO/c17-11-5-9-14-8-4-10-16(12-14)18-13-15-6-2-1-3-7-15/h4,8,10,12,15H,1-3,5-7,9,11,13,17H2
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ACUCELA INC.

US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323450
PNG
((S)-3-Amino-1-(3-(Cyclohexylmethoxy)Phenyl)Propan-...)
Show SMILES NCC[C@H](O)c1cccc(OCC2CCCCC2)c1
Show InChI InChI=1S/C16H25NO2/c17-10-9-16(18)14-7-4-8-15(11-14)19-12-13-5-2-1-3-6-13/h4,7-8,11,13,16,18H,1-3,5-6,9-10,12,17H2/t16-/m0/s1
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ACUCELA INC.

US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323461
PNG
((R)-1-Amino-3-(3-(2-Ethylbutoxy)Phenyl)Propan-2-Ol...)
Show SMILES CCC(CC)COc1cccc(C[C@@H](O)CN)c1
Show InChI InChI=1S/C15H25NO2/c1-3-12(4-2)11-18-15-7-5-6-13(9-15)8-14(17)10-16/h5-7,9,12,14,17H,3-4,8,10-11,16H2,1-2H3/t14-/m1/s1
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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323470
PNG
(3-(3-(Cyclopentylmethoxy)Phenyl)Propan-1-Amine | U...)
Show SMILES NCCCc1cccc(OCC2CCCC2)c1
Show InChI InChI=1S/C15H23NO/c16-10-4-8-13-7-3-9-15(11-13)17-12-14-5-1-2-6-14/h3,7,9,11,14H,1-2,4-6,8,10,12,16H2
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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323476
PNG
(3-Amino-1-(3-(3-Methoxypropoxy)Phenyl)Propan-1-Ol ...)
Show SMILES COCCCOc1cccc(c1)C(O)CCN
Show InChI InChI=1S/C13H21NO3/c1-16-8-3-9-17-12-5-2-4-11(10-12)13(15)6-7-14/h2,4-5,10,13,15H,3,6-9,14H2,1H3
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ACUCELA INC.

US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323483
PNG
((1,2-Trans)-2-((3-(3-Aminopropyl)Phenoxy)Methyl)Cy...)
Show SMILES NCCCc1cccc(OC[C@@H]2CCCC[C@H]2O)c1
Show InChI InChI=1S/C16H25NO2/c17-10-4-6-13-5-3-8-15(11-13)19-12-14-7-1-2-9-16(14)18/h3,5,8,11,14,16,18H,1-2,4,6-7,9-10,12,17H2/t14-,16+/m0/s1
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ACUCELA INC.

US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323492
PNG
((1S,2S)-3-Amino-1-(3-(Cyclohexylmethoxy)Phenyl)Pro...)
Show SMILES NC[C@@H](O)[C@H](O)c1cccc(OCC2CCCCC2)c1
Show InChI InChI=1S/C16H25NO3/c17-10-15(18)16(19)13-7-4-8-14(9-13)20-11-12-5-2-1-3-6-12/h4,7-9,12,15-16,18-19H,1-3,5-6,10-11,17H2/t15-,16-/m1/s1
PDB

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ACUCELA INC.

US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323495
PNG
(1-(3-(Cyclohexylmethoxy)Phenyl)-3-(Methylamino)Pro...)
Show SMILES CNCCC(O)c1cccc(OCC2CCCCC2)c1
Show InChI InChI=1S/C17H27NO2/c1-18-11-10-17(19)15-8-5-9-16(12-15)20-13-14-6-3-2-4-7-14/h5,8-9,12,14,17-19H,2-4,6-7,10-11,13H2,1H3
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ACUCELA INC.

US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323496
PNG
(3-(3-(Cyclohexylmethoxy)Phenyl)-3-Fluoropropan-1-A...)
Show SMILES NCCC(F)c1cccc(OCC2CCCCC2)c1
Show InChI InChI=1S/C16H24FNO/c17-16(9-10-18)14-7-4-8-15(11-14)19-12-13-5-2-1-3-6-13/h4,7-8,11,13,16H,1-3,5-6,9-10,12,18H2
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ACUCELA INC.

US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323497
PNG
(3-(3-(Cyclohexylmethoxy)Phenyl)Prop-2-Yn-1-Amine |...)
Show SMILES NCC#Cc1cccc(OCC2CCCCC2)c1
Show InChI InChI=1S/C16H21NO/c17-11-5-9-14-8-4-10-16(12-14)18-13-15-6-2-1-3-7-15/h4,8,10,12,15H,1-3,6-7,11,13,17H2
PDB

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ACUCELA INC.

US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323440
PNG
(3-Amino-1-(3-(Cyclohexylmethoxy)Phenyl)Propan-1-On...)
Show SMILES NCCC(=O)c1cccc(OCC2CCCCC2)c1
Show InChI InChI=1S/C16H23NO2/c17-10-9-16(18)14-7-4-8-15(11-14)19-12-13-5-2-1-3-6-13/h4,7-8,11,13H,1-3,5-6,9-10,12,17H2
PDB

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ACUCELA INC.

US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323445
PNG
(1-((3-(3-Aminopropyl)Phenoxy)Methyl)Cyclohexanol |...)
Show SMILES NCCCc1cccc(OCC2(O)CCCCC2)c1
Show InChI InChI=1S/C16H25NO2/c17-11-5-7-14-6-4-8-15(12-14)19-13-16(18)9-2-1-3-10-16/h4,6,8,12,18H,1-3,5,7,9-11,13,17H2
PDB

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ACUCELA INC.

US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323455
PNG
(2-(3-Phenethoxyphenoxy)Ethanamine | US10188615, Ex...)
Show SMILES NCCOc1cccc(OCCc2ccccc2)c1
Show InChI InChI=1S/C16H19NO2/c17-10-12-19-16-8-4-7-15(13-16)18-11-9-14-5-2-1-3-6-14/h1-8,13H,9-12,17H2
PDB

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ACUCELA INC.

US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323463
PNG
((1S,2S)-3-Amino-1-(3-(Cyclohexylmethoxy)Phenyl)-2-...)
Show SMILES C[C@@H](CN)[C@H](O)c1cccc(OCC2CCCCC2)c1
Show InChI InChI=1S/C17H27NO2/c1-13(11-18)17(19)15-8-5-9-16(10-15)20-12-14-6-3-2-4-7-14/h5,8-10,13-14,17,19H,2-4,6-7,11-12,18H2,1H3/t13-,17-/m0/s1
PDB

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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323464
PNG
((1R,2S)-3-Amino-1-(3-(Cyclohexylmethoxy)Phenyl)-2-...)
Show SMILES C[C@@H](CN)[C@@H](O)c1cccc(OCC2CCCCC2)c1
Show InChI InChI=1S/C17H27NO2/c1-13(11-18)17(19)15-8-5-9-16(10-15)20-12-14-6-3-2-4-7-14/h5,8-10,13-14,17,19H,2-4,6-7,11-12,18H2,1H3/t13-,17+/m0/s1
PDB

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ACUCELA INC.

US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323471
PNG
(2-(3-(Cyclopentylmethoxy)Phenoxy)Ethanamine | US10...)
Show SMILES NCCOc1cccc(OCC2CCCC2)c1
Show InChI InChI=1S/C14H21NO2/c15-8-9-16-13-6-3-7-14(10-13)17-11-12-4-1-2-5-12/h3,6-7,10,12H,1-2,4-5,8-9,11,15H2
PDB

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ACUCELA INC.

US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323484
PNG
(2-(3-(Cyclohexylmethoxy)-5-Methylphenoxy)Ethanamin...)
Show SMILES Cc1cc(OCCN)cc(OCC2CCCCC2)c1
Show InChI InChI=1S/C16H25NO2/c1-13-9-15(18-8-7-17)11-16(10-13)19-12-14-5-3-2-4-6-14/h9-11,14H,2-8,12,17H2,1H3
PDB

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ACUCELA INC.

US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323488
PNG
(5-(3-(3-Amino-1-Hydroxypropyl)Phenoxy)Pentan-1-Ol ...)
Show SMILES NCCC(O)c1cccc(OCCCCCO)c1
Show InChI InChI=1S/C14H23NO3/c15-8-7-14(17)12-5-4-6-13(11-12)18-10-3-1-2-9-16/h4-6,11,14,16-17H,1-3,7-10,15H2
PDB

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ACUCELA INC.

US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323441
PNG
(1-Amino-3-(3-(Cyclohexylmethoxy)Phenyl)Propan-2-Ol...)
Show SMILES NCC(O)Cc1cccc(OCC2CCCCC2)c1
Show InChI InChI=1S/C16H25NO2/c17-11-15(18)9-14-7-4-8-16(10-14)19-12-13-5-2-1-3-6-13/h4,7-8,10,13,15,18H,1-3,5-6,9,11-12,17H2
PDB

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ACUCELA INC.

US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323452
PNG
(2-(3-(2-Ethylbutoxy)Phenoxy)Ethanamine | US1018861...)
Show SMILES CCC(CC)COc1cccc(OCCN)c1
Show InChI InChI=1S/C14H23NO2/c1-3-12(4-2)11-17-14-7-5-6-13(10-14)16-9-8-15/h5-7,10,12H,3-4,8-9,11,15H2,1-2H3
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ACUCELA INC.

US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323469
PNG
(2-(3-(Cyclooctylmethoxy)Phenoxy)Ethanamine | US101...)
Show SMILES NCCOc1cccc(OCC2CCCCCCC2)c1
Show InChI InChI=1S/C17H27NO2/c18-11-12-19-16-9-6-10-17(13-16)20-14-15-7-4-2-1-3-5-8-15/h6,9-10,13,15H,1-5,7-8,11-12,14,18H2
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ACUCELA INC.

US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323478
PNG
(3-Amino-1-(3-(5-(Benzyloxy)Pentyloxy)Phenyl)Propan...)
Show SMILES NCCC(O)c1cccc(OCCCCCOCc2ccccc2)c1
Show InChI InChI=1S/C21H29NO3/c22-13-12-21(23)19-10-7-11-20(16-19)25-15-6-2-5-14-24-17-18-8-3-1-4-9-18/h1,3-4,7-11,16,21,23H,2,5-6,12-15,17,22H2
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ACUCELA INC.

US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323494
PNG
((1S,2R)-3-Amino-1-(3-(Cyclohexylmethoxy)Phenyl)Pro...)
Show SMILES NC[C@@H](O)[C@@H](O)c1cccc(OCC2CCCCC2)c1
Show InChI InChI=1S/C16H25NO3/c17-10-15(18)16(19)13-7-4-8-14(9-13)20-11-12-5-2-1-3-6-12/h4,7-9,12,15-16,18-19H,1-3,5-6,10-11,17H2/t15-,16+/m1/s1
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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323442
PNG
(2-(3-(Cyclohexylmethoxy)Phenoxy)Ethanamine | US101...)
Show SMILES NCCOc1cccc(OCC2CCCCC2)c1
Show InChI InChI=1S/C15H23NO2/c16-9-10-17-14-7-4-8-15(11-14)18-12-13-5-2-1-3-6-13/h4,7-8,11,13H,1-3,5-6,9-10,12,16H2
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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323456
PNG
((1R,2R)-2-(Aminomethyl)-1-(3-(Cyclohexylmethoxy)Ph...)
Show SMILES CC[C@H](CN)[C@@H](O)c1cccc(OCC2CCCCC2)c1
Show InChI InChI=1S/C18H29NO2/c1-2-15(12-19)18(20)16-9-6-10-17(11-16)21-13-14-7-4-3-5-8-14/h6,9-11,14-15,18,20H,2-5,7-8,12-13,19H2,1H3/t15-,18-/m1/s1
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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323462
PNG
(3-Amino-1-(3-(Cyclopropylmethoxy)Phenyl)Propan-1-O...)
Show SMILES NCCC(O)c1cccc(OCC2CC2)c1
Show InChI InChI=1S/C13H19NO2/c14-7-6-13(15)11-2-1-3-12(8-11)16-9-10-4-5-10/h1-3,8,10,13,15H,4-7,9,14H2
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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323472
PNG
(3-Amino-1-(3-(2,6-Dichlorobenzyloxy)Phenyl)Propan-...)
Show SMILES NCCC(O)c1cccc(OCc2c(Cl)cccc2Cl)c1
Show InChI InChI=1S/C16H17Cl2NO2/c17-14-5-2-6-15(18)13(14)10-21-12-4-1-3-11(9-12)16(20)7-8-19/h1-6,9,16,20H,7-8,10,19H2
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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323444
PNG
(2-(3-(Cycloheptylmethoxy)Phenoxy)Ethanamine | US10...)
Show SMILES NCCOc1cccc(OCC2CCCCCC2)c1
Show InChI InChI=1S/C16H25NO2/c17-10-11-18-15-8-5-9-16(12-15)19-13-14-6-3-1-2-4-7-14/h5,8-9,12,14H,1-4,6-7,10-11,13,17H2
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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323449
PNG
(2-(3-(2-Propylpentyloxy)Phenoxy)Ethanamine | US101...)
Show SMILES CCCC(CCC)COc1cccc(OCCN)c1
Show InChI InChI=1S/C16H27NO2/c1-3-6-14(7-4-2)13-19-16-9-5-8-15(12-16)18-11-10-17/h5,8-9,12,14H,3-4,6-7,10-11,13,17H2,1-2H3
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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323453
PNG
(3-Amino-1-(3-(Benzyloxy)Phenyl)Propan-1-Ol | US101...)
Show SMILES NCCC(O)c1cccc(OCc2ccccc2)c1
Show InChI InChI=1S/C16H19NO2/c17-10-9-16(18)14-7-4-8-15(11-14)19-12-13-5-2-1-3-6-13/h1-8,11,16,18H,9-10,12,17H2
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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323460
PNG
((R)-1-Amino-3-(3-(2-Propylpentyloxy)Phenyl)Propan-...)
Show SMILES CCCC(CCC)COc1cccc(C[C@@H](O)CN)c1
Show InChI InChI=1S/C17H29NO2/c1-3-6-14(7-4-2)13-20-17-9-5-8-15(11-17)10-16(19)12-18/h5,8-9,11,14,16,19H,3-4,6-7,10,12-13,18H2,1-2H3/t16-/m1/s1
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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323468
PNG
(3-Amino-1-(3-(2-Methoxybenzyloxy)Phenyl)Propan-1-O...)
Show SMILES COc1ccccc1COc1cccc(c1)C(O)CCN
Show InChI InChI=1S/C17H21NO3/c1-20-17-8-3-2-5-14(17)12-21-15-7-4-6-13(11-15)16(19)9-10-18/h2-8,11,16,19H,9-10,12,18H2,1H3
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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323479
PNG
(2-(3-(Cyclohexylmethoxy)Phenylthio)Ethanamine | US...)
Show SMILES NCCSc1cccc(OCC2CCCCC2)c1
Show InChI InChI=1S/C15H23NOS/c16-9-10-18-15-8-4-7-14(11-15)17-12-13-5-2-1-3-6-13/h4,7-8,11,13H,1-3,5-6,9-10,12,16H2
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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323481
PNG
(3-Amino-1-(3-(3-(Benzyloxy)Propoxy)Phenyl)Propan-1...)
Show SMILES NCCC(O)c1cccc(OCCCOCc2ccccc2)c1
Show InChI InChI=1S/C19H25NO3/c20-11-10-19(21)17-8-4-9-18(14-17)23-13-5-12-22-15-16-6-2-1-3-7-16/h1-4,6-9,14,19,21H,5,10-13,15,20H2
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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323482
PNG
((1,2-Cis)-2-((3-(3-Aminopropyl)Phenoxy)Methyl)Cycl...)
Show SMILES NCCCc1cccc(OC[C@H]2CCCC[C@H]2O)c1
Show InChI InChI=1S/C16H25NO2/c17-10-4-6-13-5-3-8-15(11-13)19-12-14-7-1-2-9-16(14)18/h3,5,8,11,14,16,18H,1-2,4,6-7,9-10,12,17H2/t14-,16-/m1/s1
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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323491
PNG
((1,2-Cis)-2-((3-((R)-3-Amino-1-Hydroxypropyl)Pheno...)
Show SMILES CC(=O)O[C@@H]1CCCC[C@@H]1COc1cccc(c1)[C@H](O)CCN
Show InChI InChI=1S/C18H27NO4/c1-13(20)23-18-8-3-2-5-15(18)12-22-16-7-4-6-14(11-16)17(21)9-10-19/h4,6-7,11,15,17-18,21H,2-3,5,8-10,12,19H2,1H3/t15-,17-,18-/m1/s1
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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323438
PNG
(3-(3-(2-Propylpentyloxy)Phenyl)Propan-1-Amine | US...)
Show SMILES CCCC(CCC)COc1cccc(CCCN)c1
Show InChI InChI=1S/C17H29NO/c1-3-7-16(8-4-2)14-19-17-11-5-9-15(13-17)10-6-12-18/h5,9,11,13,16H,3-4,6-8,10,12,14,18H2,1-2H3
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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323446
PNG
(1-((3-(3-Amino-1-Hydroxypropyl)Phenoxy)Methyl)Cycl...)
Show SMILES NCCC(O)c1cccc(OCC2(O)CCCCC2)c1
Show InChI InChI=1S/C16H25NO3/c17-10-7-15(18)13-5-4-6-14(11-13)20-12-16(19)8-2-1-3-9-16/h4-6,11,15,18-19H,1-3,7-10,12,17H2
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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323447
PNG
(3-Amino-1-(3-(Cycloheptylmethoxy)Phenyl)Propan-1-O...)
Show SMILES NCCC(=O)c1cccc(OCC2CCCCCC2)c1
Show InChI InChI=1S/C17H25NO2/c18-11-10-17(19)15-8-5-9-16(12-15)20-13-14-6-3-1-2-4-7-14/h5,8-9,12,14H,1-4,6-7,10-11,13,18H2
PDB

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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323448
PNG
(4-((3-(3-Amino-1-Hydroxypropyl)Phenoxy)Methyl)Hept...)
Show SMILES CCCC(O)(CCC)COc1cccc(c1)C(O)CCN
Show InChI InChI=1S/C17H29NO3/c1-3-9-17(20,10-4-2)13-21-15-7-5-6-14(12-15)16(19)8-11-18/h5-7,12,16,19-20H,3-4,8-11,13,18H2,1-2H3
PDB

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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323458
PNG
((S)-1-Amino-3-(3-(2-Ethylbutoxy)Phenyl)Propan-2-Ol...)
Show SMILES CCC(CC)COc1cccc(C[C@H](O)CN)c1
Show InChI InChI=1S/C15H25NO2/c1-3-12(4-2)11-18-15-7-5-6-13(9-15)8-14(17)10-16/h5-7,9,12,14,17H,3-4,8,10-11,16H2,1-2H3/t14-/m0/s1
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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323459
PNG
((S)-1-Amino-3-(3-(2-Propylpentyloxy)Phenyl)Propan-...)
Show SMILES CCCC(CCC)COc1cccc(C[C@H](O)CN)c1
Show InChI InChI=1S/C17H29NO2/c1-3-6-14(7-4-2)13-20-17-9-5-8-15(11-17)10-16(19)12-18/h5,8-9,11,14,16,19H,3-4,6-7,10,12-13,18H2,1-2H3/t16-/m0/s1
PDB

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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323439
PNG
(3-(3-(2-Ethylbutoxy)Phenyl)Propan-I-Amine | US1018...)
Show SMILES CCC(CC)COc1cccc(CCCN)c1
Show InChI InChI=1S/C15H25NO/c1-3-13(4-2)12-17-15-9-5-7-14(11-15)8-6-10-16/h5,7,9,11,13H,3-4,6,8,10,12,16H2,1-2H3
PDB

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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323454
PNG
(2-(3-(Isopentyloxy)Phenoxy)Ethanamine | US10188615...)
Show SMILES CC(C)CCOc1cccc(OCCN)c1
Show InChI InChI=1S/C13H21NO2/c1-11(2)6-8-15-12-4-3-5-13(10-12)16-9-7-14/h3-5,10-11H,6-9,14H2,1-2H3
PDB

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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323457
PNG
(3-Amino-1-(3-Phenethoxyphenyl)Propan-1-Ol | US1018...)
Show SMILES NCCC(O)c1cccc(OCCc2ccccc2)c1
Show InChI InChI=1S/C17H21NO2/c18-11-9-17(19)15-7-4-8-16(13-15)20-12-10-14-5-2-1-3-6-14/h1-8,13,17,19H,9-12,18H2
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Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323465
PNG
(3-(3-(Cyclohexylmethoxy)Phenyl)Butan-1-Amine | US1...)
Show SMILES CC(CCN)c1cccc(OCC2CCCCC2)c1
Show InChI InChI=1S/C17H27NO/c1-14(10-11-18)16-8-5-9-17(12-16)19-13-15-6-3-2-4-7-15/h5,8-9,12,14-15H,2-4,6-7,10-11,13,18H2,1H3
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Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323474
PNG
(3-Amino-1-(3-(Cyclooctylmethoxy)Phenyl)Propan-1-Ol...)
Show SMILES NCCC(O)c1cccc(OCC2CCCCCCC2)c1
Show InChI InChI=1S/C18H29NO2/c19-12-11-18(20)16-9-6-10-17(13-16)21-14-15-7-4-2-1-3-5-8-15/h6,9-10,13,15,18,20H,1-5,7-8,11-12,14,19H2
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Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323475
PNG
(3-Amino-1-(3-(Isopentyloxy)Phenyl)Propan-1-Ol | US...)
Show SMILES CC(C)CCOc1cccc(c1)C(O)CCN
Show InChI InChI=1S/C14H23NO2/c1-11(2)7-9-17-13-5-3-4-12(10-13)14(16)6-8-15/h3-5,10-11,14,16H,6-9,15H2,1-2H3
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Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323477
PNG
(3-Amino-1-(3-(4-(Benzyloxy)Butoxy)Phenyl)Propan-1-...)
Show SMILES NCCC(O)c1cccc(OCCCCOCc2ccccc2)c1
Show InChI InChI=1S/C20H27NO3/c21-12-11-20(22)18-9-6-10-19(15-18)24-14-5-4-13-23-16-17-7-2-1-3-8-17/h1-3,6-10,15,20,22H,4-5,11-14,16,21H2
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Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323485
PNG
(1-(3-(3-Amino-1-Hydroxypropyl)Phenoxy)-3-Methylbut...)
Show SMILES CC(C)C(O)COc1cccc(c1)C(O)CCN
Show InChI InChI=1S/C14H23NO3/c1-10(2)14(17)9-18-12-5-3-4-11(8-12)13(16)6-7-15/h3-5,8,10,13-14,16-17H,6-7,9,15H2,1-2H3
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Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323487
PNG
(1-(3-(3-Amino-1-Hydroxypropyl)Phenoxy)Pentan-2-Ol ...)
Show SMILES CCCC(O)COc1cccc(c1)C(O)CCN
Show InChI InChI=1S/C14H23NO3/c1-2-4-12(16)10-18-13-6-3-5-11(9-13)14(17)7-8-15/h3,5-6,9,12,14,16-17H,2,4,7-8,10,15H2,1H3
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Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323466
PNG
(3-Amino-1-(3-((Tetrahydro-2H-Pyran-2-Yl)Methoxy)Ph...)
Show SMILES NCCC(O)c1cccc(OCC2CCCCO2)c1
Show InChI InChI=1S/C15H23NO3/c16-8-7-15(17)12-4-3-6-13(10-12)19-11-14-5-1-2-9-18-14/h3-4,6,10,14-15,17H,1-2,5,7-9,11,16H2
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Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323418
PNG
(3-Amino-1-(3-(2-Propylpentyloxy)Phenyl)Propan-1-Ol...)
Show SMILES CCCC(CCC)COc1cccc(c1)C(O)CCN
Show InChI InChI=1S/C17H29NO2/c1-3-6-14(7-4-2)13-20-16-9-5-8-15(12-16)17(19)10-11-18/h5,8-9,12,14,17,19H,3-4,6-7,10-11,13,18H2,1-2H3
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Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323421
PNG
(3-Amino-1-(3-(Cyclobutylmethoxy)Phenyl)Propan-1-Ol...)
Show SMILES NCCC(O)c1cccc(OCC2CCC2)c1
Show InChI InChI=1S/C14H21NO2/c15-8-7-14(16)12-5-2-6-13(9-12)17-10-11-3-1-4-11/h2,5-6,9,11,14,16H,1,3-4,7-8,10,15H2
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Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323425
PNG
((1R,2R)-3-Amino-2-Methyl-1-(3-(2-Propylpentyloxy)P...)
Show SMILES CCCC(CCC)COc1cccc(c1)[C@H](O)[C@H](C)CN
Show InChI InChI=1S/C18H31NO2/c1-4-7-15(8-5-2)13-21-17-10-6-9-16(11-17)18(20)14(3)12-19/h6,9-11,14-15,18,20H,4-5,7-8,12-13,19H2,1-3H3/t14-,18-/m1/s1
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Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323417
PNG
(3-Amino-1-(3-(Cycloheptylmethoxy)Phenyl)Propan-1-O...)
Show SMILES NCCC(O)c1cccc(OCC2CCCCCC2)c1
Show InChI InChI=1S/C17H27NO2/c18-11-10-17(19)15-8-5-9-16(12-15)20-13-14-6-3-1-2-4-7-14/h5,8-9,12,14,17,19H,1-4,6-7,10-11,13,18H2
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Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323422
PNG
(3-Amino-1-(3-(Cyclopentylmethoxy)Phenyl)Propan-1-O...)
Show SMILES NCCC(O)c1cccc(OCC2CCCC2)c1
Show InChI InChI=1S/C15H23NO2/c16-9-8-15(17)13-6-3-7-14(10-13)18-11-12-4-1-2-5-12/h3,6-7,10,12,15,17H,1-2,4-5,8-9,11,16H2
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Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323427
PNG
((1R,2R)-3-Amino-1-(3-(2-Ethylbutoxy)Phenyl)-2-Meth...)
Show SMILES CCC(CC)COc1cccc(c1)[C@H](O)[C@H](C)CN
Show InChI InChI=1S/C16H27NO2/c1-4-13(5-2)11-19-15-8-6-7-14(9-15)16(18)12(3)10-17/h6-9,12-13,16,18H,4-5,10-11,17H2,1-3H3/t12-,16-/m1/s1
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Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323423
PNG
(3-Amino-1-(3-(2-Ethylbutoxy)Phenyl)Propan-1-Ol | U...)
Show SMILES CCC(CC)COc1cccc(c1)C(O)CCN
Show InChI InChI=1S/C15H25NO2/c1-3-12(4-2)11-18-14-7-5-6-13(10-14)15(17)8-9-16/h5-7,10,12,15,17H,3-4,8-9,11,16H2,1-2H3
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Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323424
PNG
(3-Amino-1-(3-(Bicyclo[2.2.1]Heptan-2-Ylmethoxy)Phe...)
Show SMILES NCCC(O)c1cccc(OCC2CC3CCC2C3)c1
Show InChI InChI=1S/C17H25NO2/c18-7-6-17(19)14-2-1-3-16(10-14)20-11-15-9-12-4-5-13(15)8-12/h1-3,10,12-13,15,17,19H,4-9,11,18H2
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Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323431
PNG
(3-Amino-1-(3-(4-Methoxybutoxy)Phenyl)Propan-1-Ol |...)
Show SMILES COCCCCOc1cccc(c1)C(O)CCN
Show InChI InChI=1S/C14H23NO3/c1-17-9-2-3-10-18-13-6-4-5-12(11-13)14(16)7-8-15/h4-6,11,14,16H,2-3,7-10,15H2,1H3
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Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323432
PNG
(3-Amino-1-(3-((4,4-Difluorocyclohexyl)Methoxy)Phen...)
Show SMILES NCCC(O)c1cccc(OCC2CCC(F)(F)CC2)c1
Show InChI InChI=1S/C16H23F2NO2/c17-16(18)7-4-12(5-8-16)11-21-14-3-1-2-13(10-14)15(20)6-9-19/h1-3,10,12,15,20H,4-9,11,19H2
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Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323415
PNG
(3-Amino-1-(3-(cyclohexylmethoxy)Phenyl)Propan-1-Ol...)
Show SMILES NCCC(O)c1cccc(OCC2CCCCC2)c1
Show InChI InChI=1S/C16H25NO2/c17-10-9-16(18)14-7-4-8-15(11-14)19-12-13-5-2-1-3-6-13/h4,7-8,11,13,16,18H,1-3,5-6,9-10,12,17H2
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Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323420
PNG
(3-((3-(3-Amino-1-Hydroxypropyl)Phenoxy)Methyl)Pent...)
Show SMILES CCC(O)(CC)COc1cccc(c1)C(O)CCN
Show InChI InChI=1S/C15H25NO3/c1-3-15(18,4-2)11-19-13-7-5-6-12(10-13)14(17)8-9-16/h5-7,10,14,17-18H,3-4,8-9,11,16H2,1-2H3
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Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323426
PNG
((1R,2R)-3-Amino-1-(3-(Cyclopentylmethoxy)Phenyl)-2...)
Show SMILES C[C@H](CN)[C@@H](O)c1cccc(OCC2CCCC2)c1
Show InChI InChI=1S/C16H25NO2/c1-12(10-17)16(18)14-7-4-8-15(9-14)19-11-13-5-2-3-6-13/h4,7-9,12-13,16,18H,2-3,5-6,10-11,17H2,1H3/t12-,16-/m1/s1
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Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323436
PNG
((1,2-Cis)-2-((3-((R)-3-Amino-1-Hydroxypropyl)Pheno...)
Show SMILES NCC[C@@H](O)c1cccc(OC[C@H]2CCCC[C@H]2O)c1
Show InChI InChI=1S/C16H25NO3/c17-9-8-16(19)12-5-3-6-14(10-12)20-11-13-4-1-2-7-15(13)18/h3,5-6,10,13,15-16,18-19H,1-2,4,7-9,11,17H2/t13-,15-,16-/m1/s1
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Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323433
PNG
((1,4-Cis)-4-((3-((R)-3-Amino-1-Hydroxypropyl)Pheno...)
Show SMILES NCC[C@@H](O)c1cccc(OC[C@@H]2CC[C@H](O)CC2)c1
Show InChI InChI=1S/C16H25NO3/c17-9-8-16(19)13-2-1-3-15(10-13)20-11-12-4-6-14(18)7-5-12/h1-3,10,12,14,16,18-19H,4-9,11,17H2/t12-,14+,16-/m1/s1
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Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323430
PNG
(3-Amino-1-(3-(Pentyloxy)Phenyl)Propan-1-Ol | US101...)
Show SMILES CCCCCOc1cccc(c1)C(O)CCN
Show InChI InChI=1S/C14H23NO2/c1-2-3-4-10-17-13-7-5-6-12(11-13)14(16)8-9-15/h5-7,11,14,16H,2-4,8-10,15H2,1H3
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Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323434
PNG
((1,4-Trans)-4-((3-((R)-3-Amino-1-Hydroxypropyl)Phe...)
Show SMILES NCC[C@@H](O)c1cccc(OC[C@H]2CC[C@H](O)CC2)c1
Show InChI InChI=1S/C16H25NO3/c17-9-8-16(19)13-2-1-3-15(10-13)20-11-12-4-6-14(18)7-5-12/h1-3,10,12,14,16,18-19H,4-9,11,17H2/t12-,14-,16-/m1/s1
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Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323419
PNG
((R)-3-Amino-1-(3-(Cyclohexylmethoxy)Phenyl)Propan-...)
Show SMILES NCC[C@@H](O)c1cccc(OCC2CCCCC2)c1
Show InChI InChI=1S/C16H25NO2/c17-10-9-16(18)14-7-4-8-15(11-14)19-12-13-5-2-1-3-6-13/h4,7-8,11,13,16,18H,1-3,5-6,9-10,12,17H2/t16-/m1/s1
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ACUCELA INC.

US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323429
PNG
((1R,2R)-3-Amino-1-(3-(Cyclohexylmethoxy)Phenyl)-2-...)
Show SMILES C[C@H](CN)[C@@H](O)c1cccc(OCC2CCCCC2)c1
Show InChI InChI=1S/C17H27NO2/c1-13(11-18)17(19)15-8-5-9-16(10-15)20-12-14-6-3-2-4-7-14/h5,8-10,13-14,17,19H,2-4,6-7,11-12,18H2,1H3/t13-,17-/m1/s1
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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323435
PNG
((1,2-Trans)-2-((3-((R)-3-Amino-1-Hydroxypropyl)Phe...)
Show SMILES NCC[C@@H](O)c1cccc(OC[C@@H]2CCCC[C@H]2O)c1
Show InChI InChI=1S/C16H25NO3/c17-9-8-16(19)12-5-3-6-14(10-12)20-11-13-4-1-2-7-15(13)18/h3,5-6,10,13,15-16,18-19H,1-2,4,7-9,11,17H2/t13-,15+,16+/m0/s1
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ACUCELA INC.

US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323416
PNG
(1-((3-(3-Amino-1-Hydroxypropyl)Phenoxy)Methyl)Cycl...)
Show SMILES NCCC(O)c1cccc(OCC2(O)CCCCCC2)c1
Show InChI InChI=1S/C17H27NO3/c18-11-8-16(19)14-6-5-7-15(12-14)21-13-17(20)9-3-1-2-4-10-17/h5-7,12,16,19-20H,1-4,8-11,13,18H2
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ACUCELA INC.

US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323525
PNG
(2-(3-(2,6-Dichlorobenzyloxy)Phenoxy)Ethanamine | U...)
Show SMILES NCCOc1cccc(OCc2c(Cl)cccc2Cl)c1
Show InChI InChI=1S/C15H15Cl2NO2/c16-14-5-2-6-15(17)13(14)10-20-12-4-1-3-11(9-12)19-8-7-18/h1-6,9H,7-8,10,18H2
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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323528
PNG
(2-(3-(3-Phenylpropoxy)Phenoxy)Ethanamine | US10188...)
Show SMILES NCCOc1cccc(OCCCc2ccccc2)c1
Show InChI InChI=1S/C17H21NO2/c18-11-13-20-17-10-4-9-16(14-17)19-12-5-8-15-6-2-1-3-7-15/h1-4,6-7,9-10,14H,5,8,11-13,18H2
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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323539
PNG
(2-Amino-1-(3-(Cyclohexylmethoxy)Phenyl)Ethanol | U...)
Show SMILES NCC(O)c1cccc(OCC2CCCCC2)c1
Show InChI InChI=1S/C15H23NO2/c16-10-15(17)13-7-4-8-14(9-13)18-11-12-5-2-1-3-6-12/h4,7-9,12,15,17H,1-3,5-6,10-11,16H2
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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323516
PNG
(3-(3-(Cyclobutylmethoxy)Phenyl)Propan-I-Amine | US...)
Show SMILES NCCCc1cccc(OCC2CCC2)c1
Show InChI InChI=1S/C14H21NO/c15-9-3-7-12-4-2-8-14(10-12)16-11-13-5-1-6-13/h2,4,8,10,13H,1,3,5-7,9,11,15H2
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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323519
PNG
((S)-2-(3-(Cyclopentylmethoxy)Phenoxy)Propan-1-Amin...)
Show SMILES C[C@@H](CN)Oc1cccc(OCC2CCCC2)c1
Show InChI InChI=1S/C15H23NO2/c1-12(10-16)18-15-8-4-7-14(9-15)17-11-13-5-2-3-6-13/h4,7-9,12-13H,2-3,5-6,10-11,16H2,1H3/t12-/m0/s1
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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323538
PNG
(3-(3-(Cyclohexylmethoxy)Phenyl)-3-Hydrazonopropan-...)
Show SMILES NCC\C(=N/N)c1cccc(OCC2CCCCC2)c1
Show InChI InChI=1S/C16H25N3O/c17-10-9-16(19-18)14-7-4-8-15(11-14)20-12-13-5-2-1-3-6-13/h4,7-8,11,13H,1-3,5-6,9-10,12,17-18H2/b19-16+
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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323549
PNG
(4-(3-(2-Aminoethoxy)Phenoxy)Butan-1-Ol | US1018861...)
Show SMILES NCCOc1cccc(OCCCCO)c1
Show InChI InChI=1S/C12H19NO3/c13-6-9-16-12-5-3-4-11(10-12)15-8-2-1-7-14/h3-5,10,14H,1-2,6-9,13H2
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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323553
PNG
(4-(3-(3-Amino-1-Hydroxypropyl)Phenoxy)Butan-1-Ol |...)
Show SMILES NCCC(O)c1cccc(OCCCCO)c1
Show InChI InChI=1S/C13H21NO3/c14-7-6-13(16)11-4-3-5-12(10-11)17-9-2-1-8-15/h3-5,10,13,15-16H,1-2,6-9,14H2
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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323500
PNG
(3-(3-(Cycloheptylmethoxy)Phenyl)Propan-1-Amine | U...)
Show SMILES NCCCc1cccc(OCC2CCCCCC2)c1
Show InChI InChI=1S/C17H27NO/c18-12-6-10-15-9-5-11-17(13-15)19-14-16-7-3-1-2-4-8-16/h5,9,11,13,16H,1-4,6-8,10,12,14,18H2
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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323507
PNG
(3-(3-(Pentyloxy)Phenyl)Propan-1-Amine | US10188615...)
Show SMILES CCCCCOc1cccc(CCCN)c1
Show InChI InChI=1S/C14H23NO/c1-2-3-4-11-16-14-9-5-7-13(12-14)8-6-10-15/h5,7,9,12H,2-4,6,8,10-11,15H2,1H3
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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323513
PNG
(2-(3-(Cyclobutylmethoxy)Phenoxy)Ethanamine | US101...)
Show SMILES NCCOc1cccc(OCC2CCC2)c1
Show InChI InChI=1S/C13H19NO2/c14-7-8-15-12-5-2-6-13(9-12)16-10-11-3-1-4-11/h2,5-6,9,11H,1,3-4,7-8,10,14H2
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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323522
PNG
(3-(3-(Cyclohexylmethoxy)Phenyl)but-3-En-1-Amine | ...)
Show SMILES NCCC(=C)c1cccc(OCC2CCCCC2)c1
Show InChI InChI=1S/C17H25NO/c1-14(10-11-18)16-8-5-9-17(12-16)19-13-15-6-3-2-4-7-15/h5,8-9,12,15H,1-4,6-7,10-11,13,18H2
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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323523
PNG
(4-Amino-2-(3-(Cyclohexylmethoxy)Phenyl)Butan-1-Ol ...)
Show SMILES NCCC(CO)c1cccc(OCC2CCCCC2)c1
Show InChI InChI=1S/C17H27NO2/c18-10-9-16(12-19)15-7-4-8-17(11-15)20-13-14-5-2-1-3-6-14/h4,7-8,11,14,16,19H,1-3,5-6,9-10,12-13,18H2
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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323526
PNG
(2-(3-(3-Methoxypropoxy)Phenoxy)Ethanamine | US1018...)
Show SMILES COCCCOc1cccc(OCCN)c1
Show InChI InChI=1S/C12H19NO3/c1-14-7-3-8-15-11-4-2-5-12(10-11)16-9-6-13/h2,4-5,10H,3,6-9,13H2,1H3
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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323527
PNG
(3-Amino-1-(3-(2-Methoxyethoxy)Phenyl)Propan-1-Ol |...)
Show SMILES COCCOc1cccc(c1)C(O)CCN
Show InChI InChI=1S/C12H19NO3/c1-15-7-8-16-11-4-2-3-10(9-11)12(14)5-6-13/h2-4,9,12,14H,5-8,13H2,1H3
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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323531
PNG
(3-(3-(3-Phenylpropoxy)Phenyl)Propan-1-Amine | US10...)
Show SMILES NCCCc1cccc(OCCCc2ccccc2)c1
Show InChI InChI=1S/C18H23NO/c19-13-5-10-17-9-4-12-18(15-17)20-14-6-11-16-7-2-1-3-8-16/h1-4,7-9,12,15H,5-6,10-11,13-14,19H2
PDB

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Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323533
PNG
(2-(3-(2-Methoxybenzyloxy)Phenoxy)Ethanamine | US10...)
Show SMILES COc1ccccc1COc1cccc(OCCN)c1
Show InChI InChI=1S/C16H19NO3/c1-18-16-8-3-2-5-13(16)12-20-15-7-4-6-14(11-15)19-10-9-17/h2-8,11H,9-10,12,17H2,1H3
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Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323535
PNG
(3-(3-(Thiazol-2-Ylmethoxy)Phenyl)Propan-1-Amine | ...)
Show SMILES NCCCc1cccc(OCc2nccs2)c1
Show InChI InChI=1S/C13H16N2OS/c14-6-2-4-11-3-1-5-12(9-11)16-10-13-15-7-8-17-13/h1,3,5,7-9H,2,4,6,10,14H2
PDB

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Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323540
PNG
(N′-(3-(Cyclohexylmethoxy)Phenyl)Ethane-1,2-D...)
Show SMILES NCCNc1cccc(OCC2CCCCC2)c1
Show InChI InChI=1S/C15H24N2O/c16-9-10-17-14-7-4-8-15(11-14)18-12-13-5-2-1-3-6-13/h4,7-8,11,13,17H,1-3,5-6,9-10,12,16H2
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Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323543
PNG
(2-(3-(2,6-Dimethylbenzyloxy)Phenoxy)Ethanamine | U...)
Show SMILES Cc1cccc(C)c1COc1cccc(OCCN)c1
Show InChI InChI=1S/C17H21NO2/c1-13-5-3-6-14(2)17(13)12-20-16-8-4-7-15(11-16)19-10-9-18/h3-8,11H,9-10,12,18H2,1-2H3
PDB

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Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323545
PNG
(2-(3-(3-Aminopropyl)Phenoxy)-1-Phenylethanol | US1...)
Show SMILES NCCCc1cccc(OCC(O)c2ccccc2)c1
Show InChI InChI=1S/C17H21NO2/c18-11-5-7-14-6-4-10-16(12-14)20-13-17(19)15-8-2-1-3-9-15/h1-4,6,8-10,12,17,19H,5,7,11,13,18H2
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Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323550
PNG
(4-(3-(3-Amino-1-Hydroxypropyl)Phenoxy)-N,N-Dimethy...)
Show SMILES CN(C)C(=O)CCCOc1cccc(c1)C(O)CCN
Show InChI InChI=1S/C15H24N2O3/c1-17(2)15(19)7-4-10-20-13-6-3-5-12(11-13)14(18)8-9-16/h3,5-6,11,14,18H,4,7-10,16H2,1-2H3
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ACUCELA INC.

US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323555
PNG
(3-(3-(Cyclohexylmethoxy)-5-Fluorophenyl)Propan-1-A...)
Show SMILES NCCCc1cc(F)cc(OCC2CCCCC2)c1
Show InChI InChI=1S/C16H24FNO/c17-15-9-14(7-4-8-18)10-16(11-15)19-12-13-5-2-1-3-6-13/h9-11,13H,1-8,12,18H2
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ACUCELA INC.

US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323502
PNG
(1-((3-(2-Aminoethoxy)Phenoxy)Methyl)Cyclohexanol |...)
Show SMILES NCCOc1cccc(OCC2(O)CCCCC2)c1
Show InChI InChI=1S/C15H23NO3/c16-9-10-18-13-5-4-6-14(11-13)19-12-15(17)7-2-1-3-8-15/h4-6,11,17H,1-3,7-10,12,16H2
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ACUCELA INC.

US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323504
PNG
(3-(3-(Isopentyloxy)Phenyl)Propan-1-Amine | US10188...)
Show SMILES CC(C)CCOc1cccc(CCCN)c1
Show InChI InChI=1S/C14H23NO/c1-12(2)8-10-16-14-7-3-5-13(11-14)6-4-9-15/h3,5,7,11-12H,4,6,8-10,15H2,1-2H3
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ACUCELA INC.

US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323506
PNG
(3-(3-(4-Methoxybutoxy)Phenyl)Propan-1-Amine | US10...)
Show SMILES COCCCCOc1cccc(CCCN)c1
Show InChI InChI=1S/C14H23NO2/c1-16-10-2-3-11-17-14-8-4-6-13(12-14)7-5-9-15/h4,6,8,12H,2-3,5,7,9-11,15H2,1H3
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ACUCELA INC.

US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323509
PNG
((R)-2-(3-(2-Propylpentyloxy)Phenoxy)Propan-1-Amine...)
Show SMILES CCCC(CCC)COc1cccc(O[C@H](C)CN)c1
Show InChI InChI=1S/C17H29NO2/c1-4-7-15(8-5-2)13-19-16-9-6-10-17(11-16)20-14(3)12-18/h6,9-11,14-15H,4-5,7-8,12-13,18H2,1-3H3/t14-/m1/s1
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ACUCELA INC.

US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323511
PNG
((R)-2-(3-(Cyclohexylmethoxy)Phenoxy)Propan-1-Amine...)
Show SMILES C[C@H](CN)Oc1cccc(OCC2CCCCC2)c1
Show InChI InChI=1S/C16H25NO2/c1-13(11-17)19-16-9-5-8-15(10-16)18-12-14-6-3-2-4-7-14/h5,8-10,13-14H,2-4,6-7,11-12,17H2,1H3/t13-/m1/s1
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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323515
PNG
(3-(3-(Cyclopropylmethoxy)Phenyl)Propan-1-Amine | U...)
Show SMILES NCCCc1cccc(OCC2CC2)c1
Show InChI InChI=1S/C13H19NO/c14-8-2-4-11-3-1-5-13(9-11)15-10-12-6-7-12/h1,3,5,9,12H,2,4,6-8,10,14H2
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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323517
PNG
((S)-2-(3-(2-Ethylbutoxy)Phenoxy)Propan-1-Amine | U...)
Show SMILES CCC(CC)COc1cccc(O[C@@H](C)CN)c1
Show InChI InChI=1S/C15H25NO2/c1-4-13(5-2)11-17-14-7-6-8-15(9-14)18-12(3)10-16/h6-9,12-13H,4-5,10-11,16H2,1-3H3/t12-/m0/s1
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Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323524
PNG
(2-(3-(4-Methoxybutoxy)Phenoxy)Ethanamine | US10188...)
Show SMILES COCCCCOc1cccc(OCCN)c1
Show InChI InChI=1S/C13H21NO3/c1-15-8-2-3-9-16-12-5-4-6-13(11-12)17-10-7-14/h4-6,11H,2-3,7-10,14H2,1H3
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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323536
PNG
(2-(3-(Cyclohexylmethoxy)Phenylsulfinyl)Ethanamine ...)
Show SMILES NCCS(=O)c1cccc(OCC2CCCCC2)c1
Show InChI InChI=1S/C15H23NO2S/c16-9-10-19(17)15-8-4-7-14(11-15)18-12-13-5-2-1-3-6-13/h4,7-8,11,13H,1-3,5-6,9-10,12,16H2
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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323544
PNG
(5-(3-(2-Aminoethoxy)Phenoxy)Pentan-1-Ol | US101886...)
Show SMILES NCCOc1cccc(OCCCCCO)c1
Show InChI InChI=1S/C13H21NO3/c14-7-10-17-13-6-4-5-12(11-13)16-9-3-1-2-8-15/h4-6,11,15H,1-3,7-10,14H2
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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323551
PNG
(3-(3-((Tetrahydro-2H-Pyran-2-Yl)Methoxy)Phenyl)Pro...)
Show SMILES NCCCc1cccc(OCC2CCCCO2)c1
Show InChI InChI=1S/C15H23NO2/c16-9-4-6-13-5-3-8-14(11-13)18-12-15-7-1-2-10-17-15/h3,5,8,11,15H,1-2,4,6-7,9-10,12,16H2
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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323558
PNG
((E)-3-(3-(Cyclohexylmethoxy)-5-Fluorophenyl)Prop-2...)
Show SMILES NC\C=C\c1cc(F)cc(OCC2CCCCC2)c1
Show InChI InChI=1S/C16H22FNO/c17-15-9-14(7-4-8-18)10-16(11-15)19-12-13-5-2-1-3-6-13/h4,7,9-11,13H,1-3,5-6,8,12,18H2/b7-4+
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Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323505
PNG
(3-(3-(2-Methoxybenzyloxy)Phenyl)Propan-1-Amine | U...)
Show SMILES COc1ccccc1COc1cccc(CCCN)c1
Show InChI InChI=1S/C17H21NO2/c1-19-17-10-3-2-8-15(17)13-20-16-9-4-6-14(12-16)7-5-11-18/h2-4,6,8-10,12H,5,7,11,13,18H2,1H3
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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323530
PNG
(2-(3-(3-(Benzyloxy)Propoxy)Phenoxy)Ethanamine | US...)
Show SMILES NCCOc1cccc(OCCCOCc2ccccc2)c1
Show InChI InChI=1S/C18H23NO3/c19-10-13-22-18-9-4-8-17(14-18)21-12-5-11-20-15-16-6-2-1-3-7-16/h1-4,6-9,14H,5,10-13,15,19H2
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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323532
PNG
(3-(3-(Cyclooctylmethoxy)Phenyl)Propan-1-Amine | US...)
Show SMILES NCCCc1cccc(OCC2CCCCCCC2)c1
Show InChI InChI=1S/C18H29NO/c19-13-7-11-16-10-6-12-18(14-16)20-15-17-8-4-2-1-3-5-9-17/h6,10,12,14,17H,1-5,7-9,11,13,15,19H2
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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323541
PNG
(1-((3-(3-Aminopropyl)Phenoxy)Methyl)Cyclooctanol |...)
Show SMILES NCCCc1cccc(OCC2(O)CCCCCCC2)c1
Show InChI InChI=1S/C18H29NO2/c19-13-7-9-16-8-6-10-17(14-16)21-15-18(20)11-4-2-1-3-5-12-18/h6,8,10,14,20H,1-5,7,9,11-13,15,19H2
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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323508
PNG
((R)-2-(3-(2-Ethylbutoxy)Phenoxy)Propan-1-Amine | U...)
Show SMILES CCC(CC)COc1cccc(O[C@H](C)CN)c1
Show InChI InChI=1S/C15H25NO2/c1-4-13(5-2)11-17-14-7-6-8-15(9-14)18-12(3)10-16/h6-9,12-13H,4-5,10-11,16H2,1-3H3/t12-/m1/s1
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Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323510
PNG
((R)-2-(3-(Cyclopentylmethoxy)Phenoxy)Propan-1-Amin...)
Show SMILES C[C@H](CN)Oc1cccc(OCC2CCCC2)c1
Show InChI InChI=1S/C15H23NO2/c1-12(10-16)18-15-8-4-7-14(9-15)17-11-13-5-2-3-6-13/h4,7-9,12-13H,2-3,5-6,10-11,16H2,1H3/t12-/m1/s1
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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323512
PNG
(2-(3-(Cyclopropylmethoxy)Phenoxy)Ethanamine | US10...)
Show SMILES NCCOc1cccc(OCC2CC2)c1
Show InChI InChI=1S/C12H17NO2/c13-6-7-14-11-2-1-3-12(8-11)15-9-10-4-5-10/h1-3,8,10H,4-7,9,13H2
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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323518
PNG
((S)-2-(3-(2-Propylpentyloxy)Phenoxy)Propan-1-Amine...)
Show SMILES CCCC(CCC)COc1cccc(O[C@@H](C)CN)c1
Show InChI InChI=1S/C17H29NO2/c1-4-7-15(8-5-2)13-19-16-9-6-10-17(11-16)20-14(3)12-18/h6,9-11,14-15H,4-5,7-8,12-13,18H2,1-3H3/t14-/m0/s1
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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323529
PNG
(3-(3-(2,6-Dichlorobenzyloxy)Phenyl)Propan-1-Amine ...)
Show SMILES NCCCc1cccc(OCc2c(Cl)cccc2Cl)c1
Show InChI InChI=1S/C16H17Cl2NO/c17-15-7-2-8-16(18)14(15)11-20-13-6-1-4-12(10-13)5-3-9-19/h1-2,4,6-8,10H,3,5,9,11,19H2
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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323534
PNG
(3-(3-(2-(Benzyloxy)Ethoxy)Phenyl)Propan-I-Amine | ...)
Show SMILES NCCCc1cccc(OCCOCc2ccccc2)c1
Show InChI InChI=1S/C18H23NO2/c19-11-5-9-16-8-4-10-18(14-16)21-13-12-20-15-17-6-2-1-3-7-17/h1-4,6-8,10,14H,5,9,11-13,15,19H2
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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323554
PNG
(1-(3-(3-Aminopropyl)Phenoxy)Pentan-2-Ol | US101886...)
Show SMILES CCCC(O)COc1cccc(CCCN)c1
Show InChI InChI=1S/C14H23NO2/c1-2-5-13(16)11-17-14-8-3-6-12(10-14)7-4-9-15/h3,6,8,10,13,16H,2,4-5,7,9,11,15H2,1H3
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Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323501
PNG
(1-((3-(2-Aminoethoxy)Phenoxy)Methyl)Cycloheptanol ...)
Show SMILES NCCOc1cccc(OCC2(O)CCCCCC2)c1
Show InChI InChI=1S/C16H25NO3/c17-10-11-19-14-6-5-7-15(12-14)20-13-16(18)8-3-1-2-4-9-16/h5-7,12,18H,1-4,8-11,13,17H2
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Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323503
PNG
(3-((3-(2-Aminoethoxy)Phenoxy)Methyl)Pentan-3-Ol | ...)
Show SMILES CCC(O)(CC)COc1cccc(OCCN)c1
Show InChI InChI=1S/C14H23NO3/c1-3-14(16,4-2)11-18-13-7-5-6-12(10-13)17-9-8-15/h5-7,10,16H,3-4,8-9,11,15H2,1-2H3
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ACUCELA INC.

US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323520
PNG
((S)-2-(3-(Cyclohexylmethoxy)Phenoxy)Propan-1-Amine...)
Show SMILES C[C@@H](CN)Oc1cccc(OCC2CCCCC2)c1
Show InChI InChI=1S/C16H25NO2/c1-13(11-17)19-16-9-5-8-15(10-16)18-12-14-6-3-2-4-7-14/h5,8-10,13-14H,2-4,6-7,11-12,17H2,1H3/t13-/m0/s1
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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323537
PNG
(2-(3-(Cyclohexylmethoxy)Phenylsulfonyl)Ethanamine ...)
Show SMILES NCCS(=O)(=O)c1cccc(OCC2CCCCC2)c1
Show InChI InChI=1S/C15H23NO3S/c16-9-10-20(17,18)15-8-4-7-14(11-15)19-12-13-5-2-1-3-6-13/h4,7-8,11,13H,1-3,5-6,9-10,12,16H2
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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323552
PNG
(2-(3-(Cyclohexylmethoxy)-2-Methylphenoxy)Ethanamin...)
Show SMILES Cc1c(OCCN)cccc1OCC1CCCCC1
Show InChI InChI=1S/C16H25NO2/c1-13-15(18-11-10-17)8-5-9-16(13)19-12-14-6-3-2-4-7-14/h5,8-9,14H,2-4,6-7,10-12,17H2,1H3
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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323556
PNG
((1R,2R)-3-Amino-1-(3-(Cyclohexylmethoxy)Phenyl)Pro...)
Show SMILES NC[C@H](O)[C@@H](O)c1cccc(OCC2CCCCC2)c1
Show InChI InChI=1S/C16H25NO3/c17-10-15(18)16(19)13-7-4-8-14(9-13)20-11-12-5-2-1-3-6-12/h4,7-9,12,15-16,18-19H,1-3,5-6,10-11,17H2/t15-,16-/m0/s1
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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323498
PNG
(2-(3-(Benzyloxy)Phenoxy)Ethanamine | US10188615, E...)
Show SMILES NCCOc1cccc(OCc2ccccc2)c1
Show InChI InChI=1S/C15H17NO2/c16-9-10-17-14-7-4-8-15(11-14)18-12-13-5-2-1-3-6-13/h1-8,11H,9-10,12,16H2
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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323499
PNG
(1-((3-(3-Aminopropyl)Phenoxy)Methyl)Cycloheptanol ...)
Show SMILES NCCCc1cccc(OCC2(O)CCCCCC2)c1
Show InChI InChI=1S/C17H27NO2/c18-12-6-8-15-7-5-9-16(13-15)20-14-17(19)10-3-1-2-4-11-17/h5,7,9,13,19H,1-4,6,8,10-12,14,18H2
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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323514
PNG
(3-(3-(Benzyloxy)Phenyl)Propan-1-Amine | US10188615...)
Show SMILES NCCCc1cccc(OCc2ccccc2)c1
Show InChI InChI=1S/C16H19NO/c17-11-5-9-14-8-4-10-16(12-14)18-13-15-6-2-1-3-7-15/h1-4,6-8,10,12H,5,9,11,13,17H2
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Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323521
PNG
(3-(3-Phenethoxyphenyl)Propan-1-Amine | US10188615,...)
Show SMILES NCCCc1cccc(OCCc2ccccc2)c1
Show InChI InChI=1S/C17H21NO/c18-12-5-9-16-8-4-10-17(14-16)19-13-11-15-6-2-1-3-7-15/h1-4,6-8,10,14H,5,9,11-13,18H2
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Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323542
PNG
(1-((3-(2-Aminoethoxy)Phenoxy)Methyl)Cyclooctanol |...)
Show SMILES NCCOc1cccc(OCC2(O)CCCCCCC2)c1
Show InChI InChI=1S/C17H27NO3/c18-11-12-20-15-7-6-8-16(13-15)21-14-17(19)9-4-2-1-3-5-10-17/h6-8,13,19H,1-5,9-12,14,18H2
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Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323546
PNG
(5-(3-(3-Aminopropyl)Phenoxy)Pentan-1-Ol | US101886...)
Show SMILES NCCCc1cccc(OCCCCCO)c1
Show InChI InChI=1S/C14H23NO2/c15-9-5-7-13-6-4-8-14(12-13)17-11-3-1-2-10-16/h4,6,8,12,16H,1-3,5,7,9-11,15H2
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Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323547
PNG
(1-(3-(3-Aminopropyl)Phenoxy)-3-Methylbutan-2-Ol | ...)
Show SMILES CC(C)C(O)COc1cccc(CCCN)c1
Show InChI InChI=1S/C14H23NO2/c1-11(2)14(16)10-17-13-7-3-5-12(9-13)6-4-8-15/h3,5,7,9,11,14,16H,4,6,8,10,15H2,1-2H3
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Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323548
PNG
(1-(3-(2-Aminoethoxy)Phenoxy)-3-Methylbutan-2-Ol | ...)
Show SMILES CC(C)C(O)COc1cccc(OCCN)c1
Show InChI InChI=1S/C13H21NO3/c1-10(2)13(15)9-17-12-5-3-4-11(8-12)16-7-6-14/h3-5,8,10,13,15H,6-7,9,14H2,1-2H3
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Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323557
PNG
(1-(3-(Cyclohexylmethoxy)Phenyl)-3-(Methylamino)Pro...)
Show SMILES CNCCC(=O)c1cccc(OCC2CCCCC2)c1
Show InChI InChI=1S/C17H25NO2/c1-18-11-10-17(19)15-8-5-9-16(12-15)20-13-14-6-3-2-4-7-14/h5,8-9,12,14,18H,2-4,6-7,10-11,13H2,1H3
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Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Bos taurus (Bovine))
BDBM323446
PNG
(1-((3-(3-Amino-1-Hydroxypropyl)Phenoxy)Methyl)Cycl...)
Show SMILES NCCC(O)c1cccc(OCC2(O)CCCCC2)c1
Show InChI InChI=1S/C16H25NO3/c17-10-7-15(18)13-5-4-6-14(11-13)20-12-16(19)8-2-1-3-9-16/h4-6,11,15,18-19H,1-3,7-10,12,17H2
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Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Bos taurus (Bovine))
BDBM323500
PNG
(3-(3-(Cycloheptylmethoxy)Phenyl)Propan-1-Amine | U...)
Show SMILES NCCCc1cccc(OCC2CCCCCC2)c1
Show InChI InChI=1S/C17H27NO/c18-12-6-10-15-9-5-11-17(13-15)19-14-16-7-3-1-2-4-8-16/h5,9,11,13,16H,1-4,6-8,10,12,14,18H2
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Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Bos taurus (Bovine))
BDBM323442
PNG
(2-(3-(Cyclohexylmethoxy)Phenoxy)Ethanamine | US101...)
Show SMILES NCCOc1cccc(OCC2CCCCC2)c1
Show InChI InChI=1S/C15H23NO2/c16-9-10-17-14-7-4-8-15(11-14)18-12-13-5-2-1-3-6-13/h4,7-8,11,13H,1-3,5-6,9-10,12,16H2
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Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Bos taurus (Bovine))
BDBM323448
PNG
(4-((3-(3-Amino-1-Hydroxypropyl)Phenoxy)Methyl)Hept...)
Show SMILES CCCC(O)(CCC)COc1cccc(c1)C(O)CCN
Show InChI InChI=1S/C17H29NO3/c1-3-9-17(20,10-4-2)13-21-15-7-5-6-14(12-15)16(19)8-11-18/h5-7,12,16,19-20H,3-4,8-11,13,18H2,1-2H3
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Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Bos taurus (Bovine))
BDBM323416
PNG
(1-((3-(3-Amino-1-Hydroxypropyl)Phenoxy)Methyl)Cycl...)
Show SMILES NCCC(O)c1cccc(OCC2(O)CCCCCC2)c1
Show InChI InChI=1S/C17H27NO3/c18-11-8-16(19)14-6-5-7-15(12-14)21-13-17(20)9-3-1-2-4-10-17/h5-7,12,16,19-20H,1-4,8-11,13,18H2
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Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Bos taurus (Bovine))
BDBM323419
PNG
((R)-3-Amino-1-(3-(Cyclohexylmethoxy)Phenyl)Propan-...)
Show SMILES NCC[C@@H](O)c1cccc(OCC2CCCCC2)c1
Show InChI InChI=1S/C16H25NO2/c17-10-9-16(18)14-7-4-8-15(11-14)19-12-13-5-2-1-3-6-13/h4,7-8,11,13,16,18H,1-3,5-6,9-10,12,17H2/t16-/m1/s1
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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Retinoid isomerohydrolase


(Bos taurus (Bovine))
BDBM323418
PNG
(3-Amino-1-(3-(2-Propylpentyloxy)Phenyl)Propan-1-Ol...)
Show SMILES CCCC(CCC)COc1cccc(c1)C(O)CCN
Show InChI InChI=1S/C17H29NO2/c1-3-6-14(7-4-2)13-20-16-9-5-8-15(12-16)17(19)10-11-18/h5,8-9,12,14,17,19H,3-4,6-7,10-11,13,18H2,1-2H3
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Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Bos taurus (Bovine))
BDBM323415
PNG
(3-Amino-1-(3-(cyclohexylmethoxy)Phenyl)Propan-1-Ol...)
Show SMILES NCCC(O)c1cccc(OCC2CCCCC2)c1
Show InChI InChI=1S/C16H25NO2/c17-10-9-16(18)14-7-4-8-15(11-14)19-12-13-5-2-1-3-6-13/h4,7-8,11,13,16,18H,1-3,5-6,9-10,12,17H2
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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Retinoid isomerohydrolase


(Bos taurus (Bovine))
BDBM323438
PNG
(3-(3-(2-Propylpentyloxy)Phenyl)Propan-1-Amine | US...)
Show SMILES CCCC(CCC)COc1cccc(CCCN)c1
Show InChI InChI=1S/C17H29NO/c1-3-7-16(8-4-2)14-19-17-11-5-9-15(13-17)10-6-12-18/h5,9,11,13,16H,3-4,6-8,10,12,14,18H2,1-2H3
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Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Bos taurus (Bovine))
BDBM323437
PNG
(3-(3-(Cyclohexylmethoxy)Phenyl)Propan-1-Amine | US...)
Show SMILES NCCCc1cccc(OCC2CCCCC2)c1
Show InChI InChI=1S/C16H25NO/c17-11-5-9-14-8-4-10-16(12-14)18-13-15-6-2-1-3-7-15/h4,8,10,12,15H,1-3,5-7,9,11,13,17H2
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Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Bos taurus (Bovine))
BDBM323417
PNG
(3-Amino-1-(3-(Cycloheptylmethoxy)Phenyl)Propan-1-O...)
Show SMILES NCCC(O)c1cccc(OCC2CCCCCC2)c1
Show InChI InChI=1S/C17H27NO2/c18-11-10-17(19)15-8-5-9-16(12-15)20-13-14-6-3-1-2-4-7-14/h5,8-9,12,14,17,19H,1-4,6-7,10-11,13,18H2
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Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Bos taurus (Bovine))
BDBM323450
PNG
((S)-3-Amino-1-(3-(Cyclohexylmethoxy)Phenyl)Propan-...)
Show SMILES NCC[C@H](O)c1cccc(OCC2CCCCC2)c1
Show InChI InChI=1S/C16H25NO2/c17-10-9-16(18)14-7-4-8-15(11-14)19-12-13-5-2-1-3-6-13/h4,7-8,11,13,16,18H,1-3,5-6,9-10,12,17H2/t16-/m0/s1
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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Retinoid isomerohydrolase


(Bos taurus (Bovine))
BDBM323447
PNG
(3-Amino-1-(3-(Cycloheptylmethoxy)Phenyl)Propan-1-O...)
Show SMILES NCCC(=O)c1cccc(OCC2CCCCCC2)c1
Show InChI InChI=1S/C17H25NO2/c18-11-10-17(19)15-8-5-9-16(12-15)20-13-14-6-3-1-2-4-7-14/h5,8-9,12,14H,1-4,6-7,10-11,13,18H2
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ACUCELA INC.

US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Bos taurus (Bovine))
BDBM323499
PNG
(1-((3-(3-Aminopropyl)Phenoxy)Methyl)Cycloheptanol ...)
Show SMILES NCCCc1cccc(OCC2(O)CCCCCC2)c1
Show InChI InChI=1S/C17H27NO2/c18-12-6-8-15-7-5-9-16(13-15)20-14-17(19)10-3-1-2-4-11-17/h5,7,9,13,19H,1-4,6,8,10-12,14,18H2
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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Bos taurus (Bovine))
BDBM323440
PNG
(3-Amino-1-(3-(Cyclohexylmethoxy)Phenyl)Propan-1-On...)
Show SMILES NCCC(=O)c1cccc(OCC2CCCCC2)c1
Show InChI InChI=1S/C16H23NO2/c17-10-9-16(18)14-7-4-8-15(11-14)19-12-13-5-2-1-3-6-13/h4,7-8,11,13H,1-3,5-6,9-10,12,17H2
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ACUCELA INC.

US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Bos taurus (Bovine))
BDBM323444
PNG
(2-(3-(Cycloheptylmethoxy)Phenoxy)Ethanamine | US10...)
Show SMILES NCCOc1cccc(OCC2CCCCCC2)c1
Show InChI InChI=1S/C16H25NO2/c17-10-11-18-15-8-5-9-16(12-15)19-13-14-6-3-1-2-4-7-14/h5,8-9,12,14H,1-4,6-7,10-11,13,17H2
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ACUCELA INC.

US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Bos taurus (Bovine))
BDBM323441
PNG
(1-Amino-3-(3-(Cyclohexylmethoxy)Phenyl)Propan-2-Ol...)
Show SMILES NCC(O)Cc1cccc(OCC2CCCCC2)c1
Show InChI InChI=1S/C16H25NO2/c17-11-15(18)9-14-7-4-8-16(10-14)19-12-13-5-2-1-3-6-13/h4,7-8,10,13,15,18H,1-3,5-6,9,11-12,17H2
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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Bos taurus (Bovine))
BDBM323445
PNG
(1-((3-(3-Aminopropyl)Phenoxy)Methyl)Cyclohexanol |...)
Show SMILES NCCCc1cccc(OCC2(O)CCCCC2)c1
Show InChI InChI=1S/C16H25NO2/c17-11-5-7-14-6-4-8-15(12-14)19-13-16(18)9-2-1-3-10-16/h4,6,8,12,18H,1-3,5,7,9-11,13,17H2
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ACUCELA INC.

US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Bos taurus (Bovine))
BDBM323439
PNG
(3-(3-(2-Ethylbutoxy)Phenyl)Propan-I-Amine | US1018...)
Show SMILES CCC(CC)COc1cccc(CCCN)c1
Show InChI InChI=1S/C15H25NO/c1-3-13(4-2)12-17-15-9-5-7-14(11-15)8-6-10-16/h5,7,9,11,13H,3-4,6,8,10,12,16H2,1-2H3
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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323563
PNG
(4-Amino-2-(3-(Cyclohexylmethoxy)Phenyl)Butane-1,2-...)
Show SMILES NCCC(O)(CO)c1cccc(OCC2CCCCC2)c1
Show InChI InChI=1S/C17H27NO3/c18-10-9-17(20,13-19)15-7-4-8-16(11-15)21-12-14-5-2-1-3-6-14/h4,7-8,11,14,19-20H,1-3,5-6,9-10,12-13,18H2
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ACUCELA INC.

US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323574
PNG
(4-(3-(2-Aminoethoxy)Phenoxy)-N,N-Dimethylbutanamid...)
Show SMILES CN(C)C(=O)CCCOc1cccc(OCCN)c1
Show InChI InChI=1S/C14H22N2O3/c1-16(2)14(17)7-4-9-18-12-5-3-6-13(11-12)19-10-8-15/h3,5-6,11H,4,7-10,15H2,1-2H3
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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323578
PNG
(3-Amino-1-(2-Bromo-5-(Cyclohexylmethoxy)Phenyl)Pro...)
Show SMILES NCCC(O)c1cc(OCC2CCCCC2)ccc1Br
Show InChI InChI=1S/C16H24BrNO2/c17-15-7-6-13(10-14(15)16(19)8-9-18)20-11-12-4-2-1-3-5-12/h6-7,10,12,16,19H,1-5,8-9,11,18H2
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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323580
PNG
(1-(3-(2-Aminoethoxy)Phenoxy)Pentan-2-Ol | US101886...)
Show SMILES CCCC(O)COc1cccc(OCCN)c1
Show InChI InChI=1S/C13H21NO3/c1-2-4-11(15)10-17-13-6-3-5-12(9-13)16-8-7-14/h3,5-6,9,11,15H,2,4,7-8,10,14H2,1H3
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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323570
PNG
(4-(3-(2-Aminoethoxy)Phenoxy)-N-Methylbutanamide | ...)
Show SMILES CNC(=O)CCCOc1cccc(OCCN)c1
Show InChI InChI=1S/C13H20N2O3/c1-15-13(16)6-3-8-17-11-4-2-5-12(10-11)18-9-7-14/h2,4-5,10H,3,6-9,14H2,1H3,(H,15,16)
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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323571
PNG
(2-(3-(5-(Benzyloxy)Pentyloxy)Phenoxy)Ethanamine | ...)
Show SMILES NCCOc1cccc(OCCCCCOCc2ccccc2)c1
Show InChI InChI=1S/C20H27NO3/c21-12-15-24-20-11-7-10-19(16-20)23-14-6-2-5-13-22-17-18-8-3-1-4-9-18/h1,3-4,7-11,16H,2,5-6,12-15,17,21H2
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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323583
PNG
(1-(3-(Cyclohexylmethoxy)Benzyl)Guanidine | US10188...)
Show SMILES NC(=N)NCc1cccc(OCC2CCCCC2)c1
Show InChI InChI=1S/C15H23N3O/c16-15(17)18-10-13-7-4-8-14(9-13)19-11-12-5-2-1-3-6-12/h4,7-9,12H,1-3,5-6,10-11H2,(H4,16,17,18)
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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323572
PNG
(3-(3-(5-(Benzyloxy)Pentyloxy)Phenyl)Propan-1-Amine...)
Show SMILES NCCCc1cccc(OCCCCCOCc2ccccc2)c1
Show InChI InChI=1S/C21H29NO2/c22-14-8-12-19-11-7-13-21(17-19)24-16-6-2-5-15-23-18-20-9-3-1-4-10-20/h1,3-4,7,9-11,13,17H,2,5-6,8,12,14-16,18,22H2
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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323579
PNG
(4-(3-(3-Amino-1-Hydroxypropyl)Phenoxy)Butanamide |...)
Show SMILES NCCC(O)c1cccc(OCCCC(N)=O)c1
Show InChI InChI=1S/C13H20N2O3/c14-7-6-12(16)10-3-1-4-11(9-10)18-8-2-5-13(15)17/h1,3-4,9,12,16H,2,5-8,14H2,(H2,15,17)
PDB

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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323561
PNG
((1S,2R)-3-Amino-1-(3-(Cyclohexylmethoxy)Phenyl)-2-...)
Show SMILES C[C@H](CN)[C@H](O)c1cccc(OCC2CCCCC2)c1
Show InChI InChI=1S/C17H27NO2/c1-13(11-18)17(19)15-8-5-9-16(10-15)20-12-14-6-3-2-4-7-14/h5,8-10,13-14,17,19H,2-4,6-7,11-12,18H2,1H3/t13-,17+/m1/s1
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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323577
PNG
(2-(3-(2-Aminoethoxy)Phenoxy)-1-Phenylethanol | US1...)
Show SMILES NCCOc1cccc(OCC(O)c2ccccc2)c1
Show InChI InChI=1S/C16H19NO3/c17-9-10-19-14-7-4-8-15(11-14)20-12-16(18)13-5-2-1-3-6-13/h1-8,11,16,18H,9-10,12,17H2
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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323568
PNG
(2-(3-(2-Methoxyethoxy)Phenoxy)Ethanamine | US10188...)
Show SMILES COCCOc1cccc(OCCN)c1
Show InChI InChI=1S/C11H17NO3/c1-13-7-8-15-11-4-2-3-10(9-11)14-6-5-12/h2-4,9H,5-8,12H2,1H3
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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Bos taurus (Bovine))
BDBM323501
PNG
(1-((3-(2-Aminoethoxy)Phenoxy)Methyl)Cycloheptanol ...)
Show SMILES NCCOc1cccc(OCC2(O)CCCCCC2)c1
Show InChI InChI=1S/C16H25NO3/c17-10-11-19-14-6-5-7-15(12-14)20-13-16(18)8-3-1-2-4-9-16/h5-7,12,18H,1-4,8-11,13,17H2
PDB

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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323567
PNG
(3-Amino-1-(3-(2-Hydroxyethoxy)Phenyl)Propan-1-Ol |...)
Show SMILES NCCC(O)c1cccc(OCCO)c1
Show InChI InChI=1S/C11H17NO3/c12-5-4-11(14)9-2-1-3-10(8-9)15-7-6-13/h1-3,8,11,13-14H,4-7,12H2
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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323566
PNG
(2-(3-(4-(Benzyloxy)Butoxy)Phenoxy)Ethanamine | US1...)
Show SMILES NCCOc1cccc(OCCCCOCc2ccccc2)c1
Show InChI InChI=1S/C19H25NO3/c20-11-14-23-19-10-6-9-18(15-19)22-13-5-4-12-21-16-17-7-2-1-3-8-17/h1-3,6-10,15H,4-5,11-14,16,20H2
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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323560
PNG
(3-(3-(4-(Benzyloxy)Butoxy)Phenyl)Propan-1-Amine | ...)
Show SMILES NCCCc1cccc(OCCCCOCc2ccccc2)c1
Show InChI InChI=1S/C20H27NO2/c21-13-7-11-18-10-6-12-20(16-18)23-15-5-4-14-22-17-19-8-2-1-3-9-19/h1-3,6,8-10,12,16H,4-5,7,11,13-15,17,21H2
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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323573
PNG
(3-(3-(2,6-Dimethylbenzyloxy)Phenyl)Propan-1-Amine ...)
Show SMILES Cc1cccc(C)c1COc1cccc(CCCN)c1
Show InChI InChI=1S/C18H23NO/c1-14-6-3-7-15(2)18(14)13-20-17-10-4-8-16(12-17)9-5-11-19/h3-4,6-8,10,12H,5,9,11,13,19H2,1-2H3
PDB

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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323569
PNG
(N1-(3-(Cyclohexylmethoxy)Phenyl)-N1-Methylethane-1...)
Show SMILES CN(CCN)c1cccc(OCC2CCCCC2)c1
Show InChI InChI=1S/C16H26N2O/c1-18(11-10-17)15-8-5-9-16(12-15)19-13-14-6-3-2-4-7-14/h5,8-9,12,14H,2-4,6-7,10-11,13,17H2,1H3
PDB

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US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323564
PNG
(3-(3-(2-Aminoethoxy)Phenoxy)Propan-1-Ol | US101886...)
Show SMILES NCCOc1cccc(OCCCO)c1
Show InChI InChI=1S/C11H17NO3/c12-5-8-15-11-4-1-3-10(9-11)14-7-2-6-13/h1,3-4,9,13H,2,5-8,12H2
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US Patent
n/an/a 5.50E+3n/an/an/an/an/an/a



ACUCELA INC.

US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323562
PNG
(N-(3-(3-(Cyclohexylmethoxy)Phenyl)-3-Hydroxypropyl...)
Show SMILES COCCOCCOCC(=O)NCCC(O)c1cccc(OCC2CCCCC2)c1
Show InChI InChI=1S/C23H37NO6/c1-27-12-13-28-14-15-29-18-23(26)24-11-10-22(25)20-8-5-9-21(16-20)30-17-19-6-3-2-4-7-19/h5,8-9,16,19,22,25H,2-4,6-7,10-15,17-18H2,1H3,(H,24,26)
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n/an/a 5.50E+3n/an/an/an/an/an/a



ACUCELA INC.

US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Bos taurus (Bovine))
BDBM323586
PNG
(N-(3-(3-(Cyclohexylmethoxy)Phenyl)-3-Hydroxypropyl...)
Show SMILES CC(=O)NCCC(O)c1cccc(OCC2CCCCC2)c1
Show InChI InChI=1S/C18H27NO3/c1-14(20)19-11-10-18(21)16-8-5-9-17(12-16)22-13-15-6-3-2-4-7-15/h5,8-9,12,15,18,21H,2-4,6-7,10-11,13H2,1H3,(H,19,20)
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n/an/a 5.50E+3n/an/an/an/an/an/a



ACUCELA INC.

US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323584
PNG
(4-(3-(Cyclohexylmethoxy)Phenyl)but-3-Yn-1-Amine | ...)
Show SMILES NCCC#Cc1cccc(OCC2CCCCC2)c1
Show InChI InChI=1S/C17H23NO/c18-12-5-4-7-15-10-6-11-17(13-15)19-14-16-8-2-1-3-9-16/h6,10-11,13,16H,1-3,5,8-9,12,14,18H2
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ACUCELA INC.

US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323582
PNG
(4-(3-(Cyclohexylmethoxy)Phenyl)Butan-1-Amine | US1...)
Show SMILES NCCCCc1cccc(OCC2CCCCC2)c1
Show InChI InChI=1S/C17H27NO/c18-12-5-4-7-15-10-6-11-17(13-15)19-14-16-8-2-1-3-9-16/h6,10-11,13,16H,1-5,7-9,12,14,18H2
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ACUCELA INC.

US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323581
PNG
(2-(5-(Cyclohexylmethoxy)-2-Methylphenoxy)Ethanamin...)
Show SMILES Cc1ccc(OCC2CCCCC2)cc1OCCN
Show InChI InChI=1S/C16H25NO2/c1-13-7-8-15(11-16(13)18-10-9-17)19-12-14-5-3-2-4-6-14/h7-8,11,14H,2-6,9-10,12,17H2,1H3
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ACUCELA INC.

US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323576
PNG
(4-(3-(2-Aminoethoxy)Phenoxy)Butanamide | US1018861...)
Show SMILES NCCOc1cccc(OCCCC(N)=O)c1
Show InChI InChI=1S/C12H18N2O3/c13-6-8-17-11-4-1-3-10(9-11)16-7-2-5-12(14)15/h1,3-4,9H,2,5-8,13H2,(H2,14,15)
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ACUCELA INC.

US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323575
PNG
((3-(3-Aminopropyl)-5-(Cyclohexylmethoxy)Phenyl)Met...)
Show SMILES NCCCc1cc(CO)cc(OCC2CCCCC2)c1
Show InChI InChI=1S/C17H27NO2/c18-8-4-7-15-9-16(12-19)11-17(10-15)20-13-14-5-2-1-3-6-14/h9-11,14,19H,1-8,12-13,18H2
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ACUCELA INC.

US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Bos taurus (Bovine))
BDBM323498
PNG
(2-(3-(Benzyloxy)Phenoxy)Ethanamine | US10188615, E...)
Show SMILES NCCOc1cccc(OCc2ccccc2)c1
Show InChI InChI=1S/C15H17NO2/c16-9-10-17-14-7-4-8-15(11-14)18-12-13-5-2-1-3-6-13/h1-8,11H,9-10,12,16H2
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ACUCELA INC.

US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323559
PNG
(3-(3-(2-Methoxyethoxy)Phenyl)Propan-1-Amine | US10...)
Show SMILES COCCOc1cccc(CCCN)c1
Show InChI InChI=1S/C12H19NO2/c1-14-8-9-15-12-6-2-4-11(10-12)5-3-7-13/h2,4,6,10H,3,5,7-9,13H2,1H3
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ACUCELA INC.

US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323565
PNG
(3-(3-(3-Aminopropyl)Phenoxy)Propan-1-Ol | US101886...)
Show SMILES NCCCc1cccc(OCCCO)c1
Show InChI InChI=1S/C12H19NO2/c13-7-2-5-11-4-1-6-12(10-11)15-9-3-8-14/h1,4,6,10,14H,2-3,5,7-9,13H2
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ACUCELA INC.

US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323489
PNG
(Methyl 3-(3-Aminopropyl)-5-(Cyclohexylmethoxy)Benz...)
Show SMILES COC(=O)c1cc(CCCN)cc(OCC2CCCCC2)c1
Show InChI InChI=1S/C18H27NO3/c1-21-18(20)16-10-15(8-5-9-19)11-17(12-16)22-13-14-6-3-2-4-7-14/h10-12,14H,2-9,13,19H2,1H3
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ACUCELA INC.

US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323489
PNG
(Methyl 3-(3-Aminopropyl)-5-(Cyclohexylmethoxy)Benz...)
Show SMILES COC(=O)c1cc(CCCN)cc(OCC2CCCCC2)c1
Show InChI InChI=1S/C18H27NO3/c1-21-18(20)16-10-15(8-5-9-19)11-17(12-16)22-13-14-6-3-2-4-7-14/h10-12,14H,2-9,13,19H2,1H3
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ACUCELA INC.

US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoid isomerohydrolase


(Homo sapiens (human))
BDBM323585
PNG
(1-(3-(Cyclohexylmethoxy)Phenyl)-3-(Dimethylamino)P...)
Show SMILES CN(C)CCC(=O)c1cccc(OCC2CCCCC2)c1
Show InChI InChI=1S/C18H27NO2/c1-19(2)12-11-18(20)16-9-6-10-17(13-16)21-14-15-7-4-3-5-8-15/h6,9-10,13,15H,3-5,7-8,11-12,14H2,1-2H3
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ACUCELA INC.

US Patent


Assay Description
Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoic acid receptor alpha/Retinoid X receptor alpha


(Homo sapiens)
BDBM323587
PNG
(4-[(E)-2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2...)
Show SMILES CC(=Cc1ccc(cc1)C(O)=O)c1ccc2c(c1)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C24H28O2/c1-16(14-17-6-8-18(9-7-17)22(25)26)19-10-11-20-21(15-19)24(4,5)13-12-23(20,2)3/h6-11,14-15H,12-13H2,1-5H3,(H,25,26)
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n/an/an/an/a 5.5n/an/an/an/a



ACUCELA INC.

US Patent


Assay Description
Retinoid nuclear receptor activity is associated with transduction of the non-visual physiologic, pharmacologic, and toxicologic retinoid signals tha...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoic acid receptor RXR-alpha/gamma


(Homo sapiens)
BDBM323587
PNG
(4-[(E)-2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2...)
Show SMILES CC(=Cc1ccc(cc1)C(O)=O)c1ccc2c(c1)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C24H28O2/c1-16(14-17-6-8-18(9-7-17)22(25)26)19-10-11-20-21(15-19)24(4,5)13-12-23(20,2)3/h6-11,14-15H,12-13H2,1-5H3,(H,25,26)
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n/an/an/an/a 0.0650n/an/an/an/a



ACUCELA INC.

US Patent


Assay Description
Retinoid nuclear receptor activity is associated with transduction of the non-visual physiologic, pharmacologic, and toxicologic retinoid signals tha...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor subfamily 4 group A member 2/Retinoic acid receptor RXR-alpha


(Homo sapiens)
BDBM323588
PNG
(Retinoic Acid | US10188615, at-RA | all-trans-reti...)
Show SMILES CC(C=CC1=C(C)CCCC1(C)C)=CC=CC(C)=CC(O)=O
Show InChI InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)
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n/an/an/an/a 316n/an/an/an/a



ACUCELA INC.

US Patent


Assay Description
Retinoid nuclear receptor activity is associated with transduction of the non-visual physiologic, pharmacologic, and toxicologic retinoid signals tha...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
Retinoic acid receptor RXR-alpha/Retinoic acid receptor beta


(Homo sapiens)
BDBM323587
PNG
(4-[(E)-2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2...)
Show SMILES CC(=Cc1ccc(cc1)C(O)=O)c1ccc2c(c1)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C24H28O2/c1-16(14-17-6-8-18(9-7-17)22(25)26)19-10-11-20-21(15-19)24(4,5)13-12-23(20,2)3/h6-11,14-15H,12-13H2,1-5H3,(H,25,26)
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n/an/an/an/a 0.300n/an/an/an/a



ACUCELA INC.

US Patent


Assay Description
Retinoid nuclear receptor activity is associated with transduction of the non-visual physiologic, pharmacologic, and toxicologic retinoid signals tha...


US Patent US10188615 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%