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Patent code US10189788

Compile Data Set for Download or QSAR
Found 90 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323772
PNG
(4-{[(6-Bromo-3-methyl-2-phenylquinolin-4-yl)carbon...)
Show SMILES COCSc1cc(ccc1NC(=O)c1c(C)c(nc2ccc(Br)cc12)-c1ccccc1)C(O)=O
Show InChI InChI=1S/C26H21BrN2O4S/c1-15-23(25(30)29-21-10-8-17(26(31)32)12-22(21)34-14-33-2)19-13-18(27)9-11-20(19)28-24(15)16-6-4-3-5-7-16/h3-13H,14H2,1-2H3,(H,29,30)(H,31,32)
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n/an/a 6n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, the PGF2α-induced calcium flux in recombinant FP-expressing CHO cells w...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323750
PNG
(3-Fluoro-4-{[(6-iodo-3-methyl-2-phenylquinolin-4-y...)
Show SMILES Cc1c(nc2ccc(I)cc2c1C(=O)Nc1ccc(cc1F)C(O)=O)-c1ccccc1
Show InChI InChI=1S/C24H16FIN2O3/c1-13-21(23(29)28-20-9-7-15(24(30)31)11-18(20)25)17-12-16(26)8-10-19(17)27-22(13)14-5-3-2-4-6-14/h2-12H,1H3,(H,28,29)(H,30,31)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323794
PNG
(4-{[(3-Chloro-6-iodo-2-phenylquinolin-4-yl)carbony...)
Show SMILES OC(=O)c1ccc(NC(=O)c2c(Cl)c(nc3ccc(I)cc23)-c2ccccc2)c(F)c1
Show InChI InChI=1S/C23H13ClFIN2O3/c24-20-19(22(29)28-18-8-6-13(23(30)31)10-16(18)25)15-11-14(26)7-9-17(15)27-21(20)12-4-2-1-3-5-12/h1-11H,(H,28,29)(H,30,31)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323748
PNG
(4-{[(6-Bromo-3-methyl-2-phenylquinolin-4-yl)carbon...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)Nc1ccc(cc1SC(F)(F)F)C(O)=O)-c1ccccc1
Show InChI InChI=1S/C25H16BrF3N2O3S/c1-13-21(17-12-16(26)8-10-18(17)30-22(13)14-5-3-2-4-6-14)23(32)31-19-9-7-15(24(33)34)11-20(19)35-25(27,28)29/h2-12H,1H3,(H,31,32)(H,33,34)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323795
PNG
(4-{[(6-Bromo-3-chloro-2-phenylquinolin-4-yl)carbon...)
Show SMILES OC(=O)c1ccc(NC(=O)c2c(Cl)c(nc3ccc(Br)cc23)-c2ccccc2)c(F)c1
Show InChI InChI=1S/C23H13BrClFN2O3/c24-14-7-9-17-15(11-14)19(20(25)21(27-17)12-4-2-1-3-5-12)22(29)28-18-8-6-13(23(30)31)10-16(18)26/h1-11H,(H,28,29)(H,30,31)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323772
PNG
(4-{[(6-Bromo-3-methyl-2-phenylquinolin-4-yl)carbon...)
Show SMILES COCSc1cc(ccc1NC(=O)c1c(C)c(nc2ccc(Br)cc12)-c1ccccc1)C(O)=O
Show InChI InChI=1S/C26H21BrN2O4S/c1-15-23(25(30)29-21-10-8-17(26(31)32)12-22(21)34-14-33-2)19-13-18(27)9-11-20(19)28-24(15)16-6-4-3-5-7-16/h3-13H,14H2,1-2H3,(H,29,30)(H,31,32)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323727
PNG
(4-{[(6-Bromo-3-methyl-2-phenylquinolin-4-yl)carbon...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)Nc1ccc(cc1F)C(O)=O)-c1ccccc1
Show InChI InChI=1S/C24H16BrFN2O3/c1-13-21(23(29)28-20-9-7-15(24(30)31)11-18(20)26)17-12-16(25)8-10-19(17)27-22(13)14-5-3-2-4-6-14/h2-12H,1H3,(H,28,29)(H,30,31)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323732
PNG
(4-{[(6-Bromo-3-methyl-2-phenylquinolin-4-yl)carbon...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)Nc1c(F)cc(cc1F)C(O)=O)-c1ccccc1
Show InChI InChI=1S/C24H15BrF2N2O3/c1-12-20(23(30)29-22-17(26)9-14(24(31)32)10-18(22)27)16-11-15(25)7-8-19(16)28-21(12)13-5-3-2-4-6-13/h2-11H,1H3,(H,29,30)(H,31,32)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323761
PNG
(4-{[(6-Bromo-7-chloro-3-methyl-2-phenylquinolin-4-...)
Show SMILES Cc1c(nc2cc(Cl)c(Br)cc2c1C(=O)Nc1ccc(cc1F)C(O)=O)-c1ccccc1
Show InChI InChI=1S/C24H15BrClFN2O3/c1-12-21(23(30)29-19-8-7-14(24(31)32)9-18(19)27)15-10-16(25)17(26)11-20(15)28-22(12)13-5-3-2-4-6-13/h2-11H,1H3,(H,29,30)(H,31,32)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323796
PNG
(4-{[(6-Bromo-3-cyclopropyl-2-phenylquinolin-4-yl)c...)
Show SMILES OC(=O)c1ccc(NC(=O)c2c(C3CC3)c(nc3ccc(Br)cc23)-c2ccccc2)c(F)c1
Show InChI InChI=1S/C26H18BrFN2O3/c27-17-9-11-20-18(13-17)23(25(31)30-21-10-8-16(26(32)33)12-19(21)28)22(14-6-7-14)24(29-20)15-4-2-1-3-5-15/h1-5,8-14H,6-7H2,(H,30,31)(H,32,33)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323780
PNG
(4-{[(6-Bromo-3-methyl-2-phenylquinolin-4-yl)carbon...)
Show SMILES COCS(=O)(=O)c1cc(ccc1NC(=O)c1c(C)c(nc2ccc(Br)cc12)-c1ccccc1)C(O)=O
Show InChI InChI=1S/C26H21BrN2O6S/c1-15-23(19-13-18(27)9-11-20(19)28-24(15)16-6-4-3-5-7-16)25(30)29-21-10-8-17(26(31)32)12-22(21)36(33,34)14-35-2/h3-13H,14H2,1-2H3,(H,29,30)(H,31,32)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323773
PNG
(4-{[(6-Bromo-3-methyl-2-phenylquinolin-4-yl)carbon...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)Nc1ccc(cc1S(=O)(=O)C(F)(F)F)C(O)=O)-c1ccccc1
Show InChI InChI=1S/C25H16BrF3N2O5S/c1-13-21(17-12-16(26)8-10-18(17)30-22(13)14-5-3-2-4-6-14)23(32)31-19-9-7-15(24(33)34)11-20(19)37(35,36)25(27,28)29/h2-12H,1H3,(H,31,32)(H,33,34)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323762
PNG
(4-{[(6,7-Dichloro-3-methyl-2-phenylquinolin-4-yl)c...)
Show SMILES Cc1c(nc2cc(Cl)c(Cl)cc2c1C(=O)Nc1ccc(cc1F)C(O)=O)-c1ccccc1
Show InChI InChI=1S/C24H15Cl2FN2O3/c1-12-21(23(30)29-19-8-7-14(24(31)32)9-18(19)27)15-10-16(25)17(26)11-20(15)28-22(12)13-5-3-2-4-6-13/h2-11H,1H3,(H,29,30)(H,31,32)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323764
PNG
(4-({[6-Bromo-2-(3-fluorophenyl)-3-methylquinolin-4...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)Nc1ccc(cc1F)C(O)=O)-c1cccc(F)c1
Show InChI InChI=1S/C24H15BrF2N2O3/c1-12-21(23(30)29-20-7-5-14(24(31)32)10-18(20)27)17-11-15(25)6-8-19(17)28-22(12)13-3-2-4-16(26)9-13/h2-11H,1H3,(H,29,30)(H,31,32)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323727
PNG
(4-{[(6-Bromo-3-methyl-2-phenylquinolin-4-yl)carbon...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)Nc1ccc(cc1F)C(O)=O)-c1ccccc1
Show InChI InChI=1S/C24H16BrFN2O3/c1-13-21(23(29)28-20-9-7-15(24(30)31)11-18(20)26)17-12-16(25)8-10-19(17)27-22(13)14-5-3-2-4-6-14/h2-12H,1H3,(H,28,29)(H,30,31)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, the PGF2α-induced calcium flux in recombinant FP-expressing CHO cells w...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323770
PNG
(Sodium 4-{[(6-bromo-3-methyl-2-phenylquinolin-4-yl...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)Nc1ccc(cc1F)C([O-])=O)-c1ccccc1
Show InChI InChI=1S/C24H16BrFN2O3/c1-13-21(23(29)28-20-9-7-15(24(30)31)11-18(20)26)17-12-16(25)8-10-19(17)27-22(13)14-5-3-2-4-6-14/h2-12H,1H3,(H,28,29)(H,30,31)/p-1
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323727
PNG
(4-{[(6-Bromo-3-methyl-2-phenylquinolin-4-yl)carbon...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)Nc1ccc(cc1F)C(O)=O)-c1ccccc1
Show InChI InChI=1S/C24H16BrFN2O3/c1-13-21(23(29)28-20-9-7-15(24(30)31)11-18(20)26)17-12-16(25)8-10-19(17)27-22(13)14-5-3-2-4-6-14/h2-12H,1H3,(H,28,29)(H,30,31)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, the PGF2α-induced calcium flux in recombinant FP-expressing CHO cells w...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323757
PNG
(4-({[6-Bromo-3-(fluoromethyl)-2-phenylquinolin-4-y...)
Show SMILES OC(=O)c1ccc(NC(=O)c2c(CF)c(nc3ccc(Br)cc23)-c2ccccc2)c(F)c1
Show InChI InChI=1S/C24H15BrF2N2O3/c25-15-7-9-19-16(11-15)21(17(12-26)22(28-19)13-4-2-1-3-5-13)23(30)29-20-8-6-14(24(31)32)10-18(20)27/h1-11H,12H2,(H,29,30)(H,31,32)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323730
PNG
(3-Bromo-4-{[(6-bromo-3-methyl-2-phenylquinolin-4-y...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)Nc1ccc(cc1Br)C(O)=O)-c1ccccc1
Show InChI InChI=1S/C24H16Br2N2O3/c1-13-21(23(29)28-20-9-7-15(24(30)31)11-18(20)26)17-12-16(25)8-10-19(17)27-22(13)14-5-3-2-4-6-14/h2-12H,1H3,(H,28,29)(H,30,31)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323727
PNG
(4-{[(6-Bromo-3-methyl-2-phenylquinolin-4-yl)carbon...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)Nc1ccc(cc1F)C(O)=O)-c1ccccc1
Show InChI InChI=1S/C24H16BrFN2O3/c1-13-21(23(29)28-20-9-7-15(24(30)31)11-18(20)26)17-12-16(25)8-10-19(17)27-22(13)14-5-3-2-4-6-14/h2-12H,1H3,(H,28,29)(H,30,31)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, the PGF2α-induced calcium flux in recombinant FP-expressing CHO cells w...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323770
PNG
(Sodium 4-{[(6-bromo-3-methyl-2-phenylquinolin-4-yl...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)Nc1ccc(cc1F)C([O-])=O)-c1ccccc1
Show InChI InChI=1S/C24H16BrFN2O3/c1-13-21(23(29)28-20-9-7-15(24(30)31)11-18(20)26)17-12-16(25)8-10-19(17)27-22(13)14-5-3-2-4-6-14/h2-12H,1H3,(H,28,29)(H,30,31)/p-1
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, the PGF2α-induced calcium flux in recombinant FP-expressing CHO cells w...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323735
PNG
(4-{[(6-Bromo-3-methyl-2-phenylquinolin-4-yl)carbon...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)Nc1ccc(cc1C(F)(F)F)C(O)=O)-c1ccccc1
Show InChI InChI=1S/C25H16BrF3N2O3/c1-13-21(23(32)31-20-9-7-15(24(33)34)11-18(20)25(27,28)29)17-12-16(26)8-10-19(17)30-22(13)14-5-3-2-4-6-14/h2-12H,1H3,(H,31,32)(H,33,34)
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n/an/a 45n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323770
PNG
(Sodium 4-{[(6-bromo-3-methyl-2-phenylquinolin-4-yl...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)Nc1ccc(cc1F)C([O-])=O)-c1ccccc1
Show InChI InChI=1S/C24H16BrFN2O3/c1-13-21(23(29)28-20-9-7-15(24(30)31)11-18(20)26)17-12-16(25)8-10-19(17)27-22(13)14-5-3-2-4-6-14/h2-12H,1H3,(H,28,29)(H,30,31)/p-1
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n/an/a 47n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, the PGF2α-induced calcium flux in recombinant FP-expressing CHO cells w...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323775
PNG
(4-{[(6-Bromo-5-chloro-3-methyl-2-phenylquinolin-4-...)
Show SMILES Cc1c(nc2ccc(Br)c(Cl)c2c1C(=O)Nc1ccc(cc1F)C(O)=O)-c1ccccc1
Show InChI InChI=1S/C24H15BrClFN2O3/c1-12-19(23(30)29-17-9-7-14(24(31)32)11-16(17)27)20-18(10-8-15(25)21(20)26)28-22(12)13-5-3-2-4-6-13/h2-11H,1H3,(H,29,30)(H,31,32)
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n/an/a 49n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323763
PNG
(4-({[6-Bromo-2-(4-fluorophenyl)-3-methylquinolin-4...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)Nc1ccc(cc1F)C(O)=O)-c1ccc(F)cc1
Show InChI InChI=1S/C24H15BrF2N2O3/c1-12-21(23(30)29-20-8-4-14(24(31)32)10-18(20)27)17-11-15(25)5-9-19(17)28-22(12)13-2-6-16(26)7-3-13/h2-11H,1H3,(H,29,30)(H,31,32)
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n/an/a 52n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323727
PNG
(4-{[(6-Bromo-3-methyl-2-phenylquinolin-4-yl)carbon...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)Nc1ccc(cc1F)C(O)=O)-c1ccccc1
Show InChI InChI=1S/C24H16BrFN2O3/c1-13-21(23(29)28-20-9-7-15(24(30)31)11-18(20)26)17-12-16(25)8-10-19(17)27-22(13)14-5-3-2-4-6-14/h2-12H,1H3,(H,28,29)(H,30,31)
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n/an/a 53n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, the PGF2α-induced calcium flux in recombinant FP-expressing CHO cells w...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323731
PNG
(4-{[(6-Bromo-3-methyl-2-phenylquinolin-4-yl)carbon...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)Nc1ccc(cc1I)C(O)=O)-c1ccccc1
Show InChI InChI=1S/C24H16BrIN2O3/c1-13-21(23(29)28-20-9-7-15(24(30)31)11-18(20)26)17-12-16(25)8-10-19(17)27-22(13)14-5-3-2-4-6-14/h2-12H,1H3,(H,28,29)(H,30,31)
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n/an/a 53n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323743
PNG
(4-{[(6-Bromo-3-methyl-2-phenylquinolin-4-yl)carbon...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)Nc1ccc(cc1OC(F)(F)F)C(O)=O)-c1ccccc1
Show InChI InChI=1S/C25H16BrF3N2O4/c1-13-21(17-12-16(26)8-10-18(17)30-22(13)14-5-3-2-4-6-14)23(32)31-19-9-7-15(24(33)34)11-20(19)35-25(27,28)29/h2-12H,1H3,(H,31,32)(H,33,34)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323770
PNG
(Sodium 4-{[(6-bromo-3-methyl-2-phenylquinolin-4-yl...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)Nc1ccc(cc1F)C([O-])=O)-c1ccccc1
Show InChI InChI=1S/C24H16BrFN2O3/c1-13-21(23(29)28-20-9-7-15(24(30)31)11-18(20)26)17-12-16(25)8-10-19(17)27-22(13)14-5-3-2-4-6-14/h2-12H,1H3,(H,28,29)(H,30,31)/p-1
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, the PGF2α-induced calcium flux in recombinant FP-expressing CHO cells w...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323737
PNG
(4-{[(6-Bromo-3-methyl-2-phenylquinolin-4-yl)carbon...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)Nc1ccc(cc1[N+]([O-])=O)C(O)=O)-c1ccccc1
Show InChI InChI=1S/C24H16BrN3O5/c1-13-21(23(29)27-19-9-7-15(24(30)31)11-20(19)28(32)33)17-12-16(25)8-10-18(17)26-22(13)14-5-3-2-4-6-14/h2-12H,1H3,(H,27,29)(H,30,31)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323785
PNG
(4-{[(6-Bromo-3-methyl-2-phenylquinolin-4-yl)carbon...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)Nc1ccc(C(O)=O)c(F)c1F)-c1ccccc1
Show InChI InChI=1S/C24H15BrF2N2O3/c1-12-19(23(30)29-18-10-8-15(24(31)32)20(26)21(18)27)16-11-14(25)7-9-17(16)28-22(12)13-5-3-2-4-6-13/h2-11H,1H3,(H,29,30)(H,31,32)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, the PGF2α-induced calcium flux in recombinant FP-expressing CHO cells w...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323729
PNG
(4-{[(6-Bromo-3-methyl-2-phenylquinolin-4-yl)carbon...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)Nc1ccc(cc1Cl)C(O)=O)-c1ccccc1
Show InChI InChI=1S/C24H16BrClN2O3/c1-13-21(23(29)28-20-9-7-15(24(30)31)11-18(20)26)17-12-16(25)8-10-19(17)27-22(13)14-5-3-2-4-6-14/h2-12H,1H3,(H,28,29)(H,30,31)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323756
PNG
(3-Fluoro-4-({[3-methyl-2-phenyl-6-(trimethylsilyl)...)
Show SMILES Cc1c(nc2ccc(cc2c1C(=O)Nc1ccc(cc1F)C(O)=O)[Si](C)(C)C)-c1ccccc1
Show InChI InChI=1S/C27H25FN2O3Si/c1-16-24(26(31)30-23-12-10-18(27(32)33)14-21(23)28)20-15-19(34(2,3)4)11-13-22(20)29-25(16)17-8-6-5-7-9-17/h5-15H,1-4H3,(H,30,31)(H,32,33)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323726
PNG
(6-{[(6-Bromo-3-methyl-2-phenylquinolin-4-yl)carbon...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)Nc1ncc(cc1F)C(O)=O)-c1ccccc1
Show InChI InChI=1S/C23H15BrFN3O3/c1-12-19(22(29)28-21-17(25)9-14(11-26-21)23(30)31)16-10-15(24)7-8-18(16)27-20(12)13-5-3-2-4-6-13/h2-11H,1H3,(H,30,31)(H,26,28,29)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323781
PNG
(4-{[(6-tert-Butyl-3-methyl-2-phenylquinolin-4-yl)c...)
Show SMILES Cc1c(nc2ccc(cc2c1C(=O)Nc1ccc(cc1F)C(O)=O)C(C)(C)C)-c1ccccc1
Show InChI InChI=1S/C28H25FN2O3/c1-16-24(26(32)31-23-12-10-18(27(33)34)14-21(23)29)20-15-19(28(2,3)4)11-13-22(20)30-25(16)17-8-6-5-7-9-17/h5-15H,1-4H3,(H,31,32)(H,33,34)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, the PGF2α-induced calcium flux in recombinant FP-expressing CHO cells w...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323727
PNG
(4-{[(6-Bromo-3-methyl-2-phenylquinolin-4-yl)carbon...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)Nc1ccc(cc1F)C(O)=O)-c1ccccc1
Show InChI InChI=1S/C24H16BrFN2O3/c1-13-21(23(29)28-20-9-7-15(24(30)31)11-18(20)26)17-12-16(25)8-10-19(17)27-22(13)14-5-3-2-4-6-14/h2-12H,1H3,(H,28,29)(H,30,31)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323746
PNG
(4-{[(6-Bromo-3-methyl-2-phenylquinolin-4-yl)carbon...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)Nc1ccc(cc1S(C)(=O)=O)C(O)=O)-c1ccccc1
Show InChI InChI=1S/C25H19BrN2O5S/c1-14-22(24(29)28-20-10-8-16(25(30)31)12-21(20)34(2,32)33)18-13-17(26)9-11-19(18)27-23(14)15-6-4-3-5-7-15/h3-13H,1-2H3,(H,28,29)(H,30,31)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323727
PNG
(4-{[(6-Bromo-3-methyl-2-phenylquinolin-4-yl)carbon...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)Nc1ccc(cc1F)C(O)=O)-c1ccccc1
Show InChI InChI=1S/C24H16BrFN2O3/c1-13-21(23(29)28-20-9-7-15(24(30)31)11-18(20)26)17-12-16(25)8-10-19(17)27-22(13)14-5-3-2-4-6-14/h2-12H,1H3,(H,28,29)(H,30,31)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323770
PNG
(Sodium 4-{[(6-bromo-3-methyl-2-phenylquinolin-4-yl...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)Nc1ccc(cc1F)C([O-])=O)-c1ccccc1
Show InChI InChI=1S/C24H16BrFN2O3/c1-13-21(23(29)28-20-9-7-15(24(30)31)11-18(20)26)17-12-16(25)8-10-19(17)27-22(13)14-5-3-2-4-6-14/h2-12H,1H3,(H,28,29)(H,30,31)/p-1
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323727
PNG
(4-{[(6-Bromo-3-methyl-2-phenylquinolin-4-yl)carbon...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)Nc1ccc(cc1F)C(O)=O)-c1ccccc1
Show InChI InChI=1S/C24H16BrFN2O3/c1-13-21(23(29)28-20-9-7-15(24(30)31)11-18(20)26)17-12-16(25)8-10-19(17)27-22(13)14-5-3-2-4-6-14/h2-12H,1H3,(H,28,29)(H,30,31)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323754
PNG
(3-Fluoro-4-({[3-methyl-2-phenyl-6-(trifluoromethyl...)
Show SMILES Cc1c(nc2ccc(cc2c1C(=O)Nc1ccc(cc1F)C(O)=O)C(F)(F)F)-c1ccccc1
Show InChI InChI=1S/C25H16F4N2O3/c1-13-21(23(32)31-20-9-7-15(24(33)34)11-18(20)26)17-12-16(25(27,28)29)8-10-19(17)30-22(13)14-5-3-2-4-6-14/h2-12H,1H3,(H,31,32)(H,33,34)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323747
PNG
(4-{[(6-Bromo-3-methyl-2-phenylquinolin-4-yl)carbon...)
Show SMILES CCS(=O)(=O)c1cc(C(O)=O)c(OC)cc1NC(=O)c1c(C)c(nc2ccc(Br)cc12)-c1ccccc1
Show InChI InChI=1S/C27H23BrN2O6S/c1-4-37(34,35)23-13-19(27(32)33)22(36-3)14-21(23)30-26(31)24-15(2)25(16-8-6-5-7-9-16)29-20-11-10-17(28)12-18(20)24/h5-14H,4H2,1-3H3,(H,30,31)(H,32,33)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323798
PNG
(4-{[(6-Bromo-3-fluoro-2-phenylquinolin-4-yl)carbon...)
Show SMILES OC(=O)c1ccc(NC(=O)c2c(F)c(nc3ccc(Br)cc23)-c2ccccc2)c(F)c1
Show InChI InChI=1S/C23H13BrF2N2O3/c24-14-7-9-17-15(11-14)19(20(26)21(27-17)12-4-2-1-3-5-12)22(29)28-18-8-6-13(23(30)31)10-16(18)25/h1-11H,(H,28,29)(H,30,31)
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n/an/a 98n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, the PGF2α-induced calcium flux in recombinant FP-expressing CHO cells w...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323768
PNG
(6-Bromo-N-(4-carbamoyl-2-fluorophenyl)-3-methyl-2-...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)Nc1ccc(cc1F)C(N)=O)-c1ccccc1
Show InChI InChI=1S/C24H17BrFN3O2/c1-13-21(24(31)29-20-9-7-15(23(27)30)11-18(20)26)17-12-16(25)8-10-19(17)28-22(13)14-5-3-2-4-6-14/h2-12H,1H3,(H2,27,30)(H,29,31)
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n/an/a 102n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323774
PNG
(4-{[(6-Bromo-3-methyl-1-oxido-2-phenylquinolin-4-y...)
Show SMILES Cc1c(C(=O)Nc2ccc(cc2SC(F)(F)F)C(O)=O)c2cc(Br)ccc2[n+]([O-])c1-c1ccccc1
Show InChI InChI=1S/C25H16BrF3N2O4S/c1-13-21(23(32)30-18-9-7-15(24(33)34)11-20(18)36-25(27,28)29)17-12-16(26)8-10-19(17)31(35)22(13)14-5-3-2-4-6-14/h2-12H,1H3,(H,30,32)(H,33,34)
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n/an/a 102n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323770
PNG
(Sodium 4-{[(6-bromo-3-methyl-2-phenylquinolin-4-yl...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)Nc1ccc(cc1F)C([O-])=O)-c1ccccc1
Show InChI InChI=1S/C24H16BrFN2O3/c1-13-21(23(29)28-20-9-7-15(24(30)31)11-18(20)26)17-12-16(25)8-10-19(17)27-22(13)14-5-3-2-4-6-14/h2-12H,1H3,(H,28,29)(H,30,31)/p-1
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n/an/a 104n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323785
PNG
(4-{[(6-Bromo-3-methyl-2-phenylquinolin-4-yl)carbon...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)Nc1ccc(C(O)=O)c(F)c1F)-c1ccccc1
Show InChI InChI=1S/C24H15BrF2N2O3/c1-12-19(23(30)29-18-10-8-15(24(31)32)20(26)21(18)27)16-11-14(25)7-9-17(16)28-22(12)13-5-3-2-4-6-13/h2-11H,1H3,(H,29,30)(H,31,32)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323769
PNG
(4-{[(6-Bromo-3-methyl-1-oxido-2-phenylquinolin-4-y...)
Show SMILES Cc1c(C(=O)Nc2ccc(cc2F)C(O)=O)c2cc(Br)ccc2[n+]([O-])c1-c1ccccc1
Show InChI InChI=1S/C24H16BrFN2O4/c1-13-21(23(29)27-19-9-7-15(24(30)31)11-18(19)26)17-12-16(25)8-10-20(17)28(32)22(13)14-5-3-2-4-6-14/h2-12H,1H3,(H,27,29)(H,30,31)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323744
PNG
(4-{[(6-Bromo-3-methyl-2-phenylquinolin-4-yl)carbon...)
Show SMILES CSc1cc(ccc1NC(=O)c1c(C)c(nc2ccc(Br)cc12)-c1ccccc1)C(O)=O
Show InChI InChI=1S/C25H19BrN2O3S/c1-14-22(24(29)28-20-10-8-16(25(30)31)12-21(20)32-2)18-13-17(26)9-11-19(18)27-23(14)15-6-4-3-5-7-15/h3-13H,1-2H3,(H,28,29)(H,30,31)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323781
PNG
(4-{[(6-tert-Butyl-3-methyl-2-phenylquinolin-4-yl)c...)
Show SMILES Cc1c(nc2ccc(cc2c1C(=O)Nc1ccc(cc1F)C(O)=O)C(C)(C)C)-c1ccccc1
Show InChI InChI=1S/C28H25FN2O3/c1-16-24(26(32)31-23-12-10-18(27(33)34)14-21(23)29)20-15-19(28(2,3)4)11-13-22(20)30-25(16)17-8-6-5-7-9-17/h5-15H,1-4H3,(H,31,32)(H,33,34)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323787
PNG
(6-Bromo-N-(2-fluoro-4-{[(trifluoromethyl)sulfonyl]...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)Nc1ccc(cc1F)C(=O)NS(=O)(=O)C(F)(F)F)-c1ccccc1
Show InChI InChI=1S/C25H16BrF4N3O4S/c1-13-21(17-12-16(26)8-10-19(17)31-22(13)14-5-3-2-4-6-14)24(35)32-20-9-7-15(11-18(20)27)23(34)33-38(36,37)25(28,29)30/h2-12H,1H3,(H,32,35)(H,33,34)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, the PGF2α-induced calcium flux in recombinant FP-expressing CHO cells w...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323766
PNG
(4-({[6-Bromo-3-methyl-2-(pyridin-4-yl)quinolin-4-y...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)Nc1ccc(cc1F)C(O)=O)-c1ccncc1
Show InChI InChI=1S/C23H15BrFN3O3/c1-12-20(22(29)28-19-4-2-14(23(30)31)10-17(19)25)16-11-15(24)3-5-18(16)27-21(12)13-6-8-26-9-7-13/h2-11H,1H3,(H,28,29)(H,30,31)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323722
PNG
(6-{[(6-Bromo-3-methyl-2-phenylquinolin-4-yl)carbon...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)Nc1ccc(cn1)C(O)=O)-c1ccccc1
Show InChI InChI=1S/C23H16BrN3O3/c1-13-20(22(28)27-19-10-7-15(12-25-19)23(29)30)17-11-16(24)8-9-18(17)26-21(13)14-5-3-2-4-6-14/h2-12H,1H3,(H,29,30)(H,25,27,28)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323733
PNG
(4-{[(6-Bromo-3-methyl-2-phenylquinolin-4-yl)carbon...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)Nc1c(Cl)cc(cc1Cl)C(O)=O)-c1ccccc1
Show InChI InChI=1S/C24H15BrCl2N2O3/c1-12-20(23(30)29-22-17(26)9-14(24(31)32)10-18(22)27)16-11-15(25)7-8-19(16)28-21(12)13-5-3-2-4-6-13/h2-11H,1H3,(H,29,30)(H,31,32)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323797
PNG
(4-{[(6-Bromo-3,8-dimethyl-2-phenylquinolin-4-yl)ca...)
Show SMILES Cc1cc(Br)cc2c(C(=O)Nc3ccc(cc3F)C(O)=O)c(C)c(nc12)-c1ccccc1
Show InChI InChI=1S/C25H18BrFN2O3/c1-13-10-17(26)12-18-21(14(2)23(29-22(13)18)15-6-4-3-5-7-15)24(30)28-20-9-8-16(25(31)32)11-19(20)27/h3-12H,1-2H3,(H,28,30)(H,31,32)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323751
PNG
(4-{[(3,6-Dimethyl-2-phenylquinolin-4-yl)carbonyl]a...)
Show SMILES Cc1ccc2nc(c(C)c(C(=O)Nc3ccc(cc3F)C(O)=O)c2c1)-c1ccccc1
Show InChI InChI=1S/C25H19FN2O3/c1-14-8-10-20-18(12-14)22(15(2)23(27-20)16-6-4-3-5-7-16)24(29)28-21-11-9-17(25(30)31)13-19(21)26/h3-13H,1-2H3,(H,28,29)(H,30,31)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323705
PNG
(4-{[(6-Bromo-3-methyl-2-phenylquinolin-4-yl)carbon...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)Nc1ccc(cc1)C(O)=O)-c1ccccc1
Show InChI InChI=1S/C24H17BrN2O3/c1-14-21(23(28)26-18-10-7-16(8-11-18)24(29)30)19-13-17(25)9-12-20(19)27-22(14)15-5-3-2-4-6-15/h2-13H,1H3,(H,26,28)(H,29,30)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323723
PNG
(5-{[(6-Bromo-3-methyl-2-phenylquinolin-4-yl)carbon...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)Nc1cnc(cn1)C(O)=O)-c1ccccc1
Show InChI InChI=1S/C22H15BrN4O3/c1-12-19(21(28)27-18-11-24-17(10-25-18)22(29)30)15-9-14(23)7-8-16(15)26-20(12)13-5-3-2-4-6-13/h2-11H,1H3,(H,29,30)(H,25,27,28)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323788
PNG
(6-Bromo-N-{4-[(dimethylsulfamoyl)carbamoyl]-2-fluo...)
Show SMILES CN(C)S(=O)(=O)NC(=O)c1ccc(NC(=O)c2c(C)c(nc3ccc(Br)cc23)-c2ccccc2)c(F)c1
Show InChI InChI=1S/C26H22BrFN4O4S/c1-15-23(19-14-18(27)10-12-21(19)29-24(15)16-7-5-4-6-8-16)26(34)30-22-11-9-17(13-20(22)28)25(33)31-37(35,36)32(2)3/h4-14H,1-3H3,(H,30,34)(H,31,33)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, the PGF2α-induced calcium flux in recombinant FP-expressing CHO cells w...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323759
PNG
(4-{[(6-Bromo-3-ethyl-2-phenylquinolin-4-yl)carbony...)
Show SMILES CCc1c(nc2ccc(Br)cc2c1C(=O)Nc1ccc(cc1F)C(O)=O)-c1ccccc1
Show InChI InChI=1S/C25H18BrFN2O3/c1-2-17-22(24(30)29-21-10-8-15(25(31)32)12-19(21)27)18-13-16(26)9-11-20(18)28-23(17)14-6-4-3-5-7-14/h3-13H,2H2,1H3,(H,29,30)(H,31,32)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323767
PNG
(6-Bromo-N-(4-carbamoylphenyl)-3-methyl-2-phenylqui...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)Nc1ccc(cc1)C(N)=O)-c1ccccc1
Show InChI InChI=1S/C24H18BrN3O2/c1-14-21(24(30)27-18-10-7-16(8-11-18)23(26)29)19-13-17(25)9-12-20(19)28-22(14)15-5-3-2-4-6-15/h2-13H,1H3,(H2,26,29)(H,27,30)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323779
PNG
(4-{[(6-Chloro-3-methyl-2-phenylquinolin-4-yl)carbo...)
Show SMILES Cc1c(nc2ccc(Cl)cc2c1C(=O)Nc1ccc(cc1F)C(O)=O)-c1ccccc1
Show InChI InChI=1S/C24H16ClFN2O3/c1-13-21(23(29)28-20-9-7-15(24(30)31)11-18(20)26)17-12-16(25)8-10-19(17)27-22(13)14-5-3-2-4-6-14/h2-12H,1H3,(H,28,29)(H,30,31)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323741
PNG
(4-{[(6-Bromo-3-methyl-2-phenylquinolin-4-yl)carbon...)
Show SMILES COc1cc(ccc1NC(=O)c1c(C)c(nc2ccc(Br)cc12)-c1ccccc1)C(O)=O
Show InChI InChI=1S/C25H19BrN2O4/c1-14-22(24(29)28-20-10-8-16(25(30)31)12-21(20)32-2)18-13-17(26)9-11-19(18)27-23(14)15-6-4-3-5-7-15/h3-13H,1-2H3,(H,28,29)(H,30,31)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323765
PNG
(4-({[6-Bromo-2-(2-fluorophenyl)-3-methylquinolin-4...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)Nc1ccc(cc1F)C(O)=O)-c1ccccc1F
Show InChI InChI=1S/C24H15BrF2N2O3/c1-12-21(23(30)29-20-8-6-13(24(31)32)10-18(20)27)16-11-14(25)7-9-19(16)28-22(12)15-4-2-3-5-17(15)26/h2-11H,1H3,(H,29,30)(H,31,32)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323793
PNG
(4-{[(6-Bromo-3-methoxy-2-phenylquinolin-4-yl)carbo...)
Show SMILES COc1c(nc2ccc(Br)cc2c1C(=O)Nc1ccc(cc1F)C(O)=O)-c1ccccc1
Show InChI InChI=1S/C24H16BrFN2O4/c1-32-22-20(23(29)28-19-9-7-14(24(30)31)11-17(19)26)16-12-15(25)8-10-18(16)27-21(22)13-5-3-2-4-6-13/h2-12H,1H3,(H,28,29)(H,30,31)
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n/an/a 220n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323787
PNG
(6-Bromo-N-(2-fluoro-4-{[(trifluoromethyl)sulfonyl]...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)Nc1ccc(cc1F)C(=O)NS(=O)(=O)C(F)(F)F)-c1ccccc1
Show InChI InChI=1S/C25H16BrF4N3O4S/c1-13-21(17-12-16(26)8-10-19(17)31-22(13)14-5-3-2-4-6-14)24(35)32-20-9-7-15(11-18(20)27)23(34)33-38(36,37)25(28,29)30/h2-12H,1H3,(H,32,35)(H,33,34)
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n/an/a 239n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323752
PNG
(4-{[(6-Ethyl-3-methyl-2-phenylquinolin-4-yl)carbon...)
Show SMILES CCc1ccc2nc(c(C)c(C(=O)Nc3ccc(cc3F)C(O)=O)c2c1)-c1ccccc1
Show InChI InChI=1S/C26H21FN2O3/c1-3-16-9-11-21-19(13-16)23(15(2)24(28-21)17-7-5-4-6-8-17)25(30)29-22-12-10-18(26(31)32)14-20(22)27/h4-14H,3H2,1-2H3,(H,29,30)(H,31,32)
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n/an/a 245n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323783
PNG
(3-Fluoro-4-({[3-methyl-6-(pentafluoro-λ6-sulf...)
Show SMILES Cc1c(nc2ccc(cc2c1C(=O)Nc1ccc(cc1F)C(O)=O)S(F)(F)(F)(F)F)-c1ccccc1
Show InChI InChI=1S/C24H16F6N2O3S/c1-13-21(23(33)32-20-9-7-15(24(34)35)11-18(20)25)17-12-16(36(26,27,28,29)30)8-10-19(17)31-22(13)14-5-3-2-4-6-14/h2-12H,1H3,(H,32,33)(H,34,35)
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n/an/a 246n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323758
PNG
(4-({[6-Bromo-3-(difluoromethyl)-2-phenylquinolin-4...)
Show SMILES OC(=O)c1ccc(NC(=O)c2c(C(F)F)c(nc3ccc(Br)cc23)-c2ccccc2)c(F)c1
Show InChI InChI=1S/C24H14BrF3N2O3/c25-14-7-9-17-15(11-14)19(20(22(27)28)21(29-17)12-4-2-1-3-5-12)23(31)30-18-8-6-13(24(32)33)10-16(18)26/h1-11,22H,(H,30,31)(H,32,33)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323753
PNG
(3-Fluoro-4-{[(6-isopropyl-3-methyl-2-phenylquinoli...)
Show SMILES CC(C)c1ccc2nc(c(C)c(C(=O)Nc3ccc(cc3F)C(O)=O)c2c1)-c1ccccc1
Show InChI InChI=1S/C27H23FN2O3/c1-15(2)18-9-11-22-20(13-18)24(16(3)25(29-22)17-7-5-4-6-8-17)26(31)30-23-12-10-19(27(32)33)14-21(23)28/h4-15H,1-3H3,(H,30,31)(H,32,33)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323736
PNG
(4-{[(6-Bromo-3-methyl-2-phenylquinolin-4-yl)carbon...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)Nc1ccc(cc1C#N)C(O)=O)-c1ccccc1
Show InChI InChI=1S/C25H16BrN3O3/c1-14-22(24(30)29-20-9-7-16(25(31)32)11-17(20)13-27)19-12-18(26)8-10-21(19)28-23(14)15-5-3-2-4-6-15/h2-12H,1H3,(H,29,30)(H,31,32)
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n/an/a 278n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323786
PNG
(4-{[(6-Bromo-3-methyl-2-phenylquinolin-4-yl)carbon...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)Nc1cc(F)c(cc1F)C(O)=O)-c1ccccc1
Show InChI InChI=1S/C24H15BrF2N2O3/c1-12-21(23(30)29-20-11-17(26)15(24(31)32)10-18(20)27)16-9-14(25)7-8-19(16)28-22(12)13-5-3-2-4-6-13/h2-11H,1H3,(H,29,30)(H,31,32)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323776
PNG
(6-Bromo-N-[2-fluoro-4-(methylcarbamoyl)phenyl]-3-m...)
Show SMILES CNC(=O)c1ccc(NC(=O)c2c(C)c(nc3ccc(Br)cc23)-c2ccccc2)c(F)c1
Show InChI InChI=1S/C25H19BrFN3O2/c1-14-22(25(32)30-21-10-8-16(12-19(21)27)24(31)28-2)18-13-17(26)9-11-20(18)29-23(14)15-6-4-3-5-7-15/h3-13H,1-2H3,(H,28,31)(H,30,32)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323755
PNG
(3-Fluoro-4-({[3-methyl-2-phenyl-6-(trifluoromethox...)
Show SMILES Cc1c(nc2ccc(OC(F)(F)F)cc2c1C(=O)Nc1ccc(cc1F)C(O)=O)-c1ccccc1
Show InChI InChI=1S/C25H16F4N2O4/c1-13-21(23(32)31-20-9-7-15(24(33)34)11-18(20)26)17-12-16(35-25(27,28)29)8-10-19(17)30-22(13)14-5-3-2-4-6-14/h2-12H,1H3,(H,31,32)(H,33,34)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323742
PNG
(4-{[(6-Bromo-3-methyl-2-phenylquinolin-4-yl)carbon...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)Nc1ccc(cc1O)C(O)=O)-c1ccccc1
Show InChI InChI=1S/C24H17BrN2O4/c1-13-21(23(29)27-19-9-7-15(24(30)31)11-20(19)28)17-12-16(25)8-10-18(17)26-22(13)14-5-3-2-4-6-14/h2-12,28H,1H3,(H,27,29)(H,30,31)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323782
PNG
(3-Bromo-4-({[6-bromo-2-phenyl-3-(trifluoromethyl)q...)
Show SMILES OC(=O)c1cc(F)c(NC(=O)c2c(c(nc3ccc(Br)cc23)-c2ccccc2)C(F)(F)F)c(Br)c1
Show InChI InChI=1S/C24H12Br2F4N2O3/c25-13-6-7-17-14(10-13)18(19(24(28,29)30)20(31-17)11-4-2-1-3-5-11)22(33)32-21-15(26)8-12(23(34)35)9-16(21)27/h1-10H,(H,32,33)(H,34,35)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323788
PNG
(6-Bromo-N-{4-[(dimethylsulfamoyl)carbamoyl]-2-fluo...)
Show SMILES CN(C)S(=O)(=O)NC(=O)c1ccc(NC(=O)c2c(C)c(nc3ccc(Br)cc23)-c2ccccc2)c(F)c1
Show InChI InChI=1S/C26H22BrFN4O4S/c1-15-23(19-14-18(27)10-12-21(19)29-24(15)16-7-5-4-6-8-16)26(34)30-22-11-9-17(13-20(22)28)25(33)31-37(35,36)32(2)3/h4-14H,1-3H3,(H,30,34)(H,31,33)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323738
PNG
(3-Amino-4-{[(6-bromo-3-methyl-2-phenylquinolin-4-y...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)Nc1ccc(cc1N)C(O)=O)-c1ccccc1
Show InChI InChI=1S/C24H18BrN3O3/c1-13-21(23(29)28-20-9-7-15(24(30)31)11-18(20)26)17-12-16(25)8-10-19(17)27-22(13)14-5-3-2-4-6-14/h2-12H,26H2,1H3,(H,28,29)(H,30,31)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323784
PNG
(4-({[6-(Difluoromethyl)-3-methyl-2-phenylquinolin-...)
Show SMILES Cc1c(nc2ccc(cc2c1C(=O)Nc1ccc(cc1F)C(O)=O)C(F)F)-c1ccccc1
Show InChI InChI=1S/C25H17F3N2O3/c1-13-21(24(31)30-20-10-8-16(25(32)33)12-18(20)26)17-11-15(23(27)28)7-9-19(17)29-22(13)14-5-3-2-4-6-14/h2-12,23H,1H3,(H,30,31)(H,32,33)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323777
PNG
(4-({[6-Bromo-2-phenyl-3-(trifluoromethyl)quinolin-...)
Show SMILES OC(=O)c1ccc(NC(=O)c2c(c(nc3ccc(Br)cc23)-c2ccccc2)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C24H13BrF4N2O3/c25-14-7-9-17-15(11-14)19(22(32)31-18-8-6-13(23(33)34)10-16(18)26)20(24(27,28)29)21(30-17)12-4-2-1-3-5-12/h1-11H,(H,31,32)(H,33,34)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323740
PNG
(4-{[(6-Bromo-3-methyl-2-phenylquinolin-4-yl)carbon...)
Show SMILES CCNC(=O)Nc1cc(ccc1NC(=O)c1c(C)c(nc2ccc(Br)cc12)-c1ccccc1)C(O)=O
Show InChI InChI=1S/C27H23BrN4O4/c1-3-29-27(36)32-22-13-17(26(34)35)9-11-21(22)31-25(33)23-15(2)24(16-7-5-4-6-8-16)30-20-12-10-18(28)14-19(20)23/h4-14H,3H2,1-2H3,(H,31,33)(H,34,35)(H2,29,32,36)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323778
PNG
(4-{[(6-Bromo-3,8-dimethyl-2-phenylquinolin-4-yl)ca...)
Show SMILES Cc1cc(Br)cc2c(C(=O)Nc3ccc(cc3)C(O)=O)c(C)c(nc12)-c1ccccc1
Show InChI InChI=1S/C25H19BrN2O3/c1-14-12-18(26)13-20-21(24(29)27-19-10-8-17(9-11-19)25(30)31)15(2)23(28-22(14)20)16-6-4-3-5-7-16/h3-13H,1-2H3,(H,27,29)(H,30,31)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323760
PNG
(4-{[(6-Bromo-2-phenyl-3-propylquinolin-4-yl)carbon...)
Show SMILES CCCc1c(nc2ccc(Br)cc2c1C(=O)Nc1ccc(cc1F)C(O)=O)-c1ccccc1
Show InChI InChI=1S/C26H20BrFN2O3/c1-2-6-18-23(25(31)30-22-11-9-16(26(32)33)13-20(22)28)19-14-17(27)10-12-21(19)29-24(18)15-7-4-3-5-8-15/h3-5,7-14H,2,6H2,1H3,(H,30,31)(H,32,33)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323734
PNG
(4-{[(6-Bromo-3-methyl-2-phenylquinolin-4-yl)carbon...)
Show SMILES Cc1cc(ccc1NC(=O)c1c(C)c(nc2ccc(Br)cc12)-c1ccccc1)C(O)=O
Show InChI InChI=1S/C25H19BrN2O3/c1-14-12-17(25(30)31)8-10-20(14)28-24(29)22-15(2)23(16-6-4-3-5-7-16)27-21-11-9-18(26)13-19(21)22/h3-13H,1-2H3,(H,28,29)(H,30,31)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323739
PNG
(3-Acetamido-4-{[(6-bromo-3-methyl-2-phenylquinolin...)
Show SMILES CC(=O)Nc1cc(ccc1NC(=O)c1c(C)c(nc2ccc(Br)cc12)-c1ccccc1)C(O)=O
Show InChI InChI=1S/C26H20BrN3O4/c1-14-23(25(32)30-21-10-8-17(26(33)34)12-22(21)28-15(2)31)19-13-18(27)9-11-20(19)29-24(14)16-6-4-3-5-7-16/h3-13H,1-2H3,(H,28,31)(H,30,32)(H,33,34)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323745
PNG
(4-{[(6-Bromo-3-methyl-2-phenylquinolin-4-yl)carbon...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)Nc1ccc(cc1S(C)=O)C(O)=O)-c1ccccc1
Show InChI InChI=1S/C25H19BrN2O4S/c1-14-22(24(29)28-20-10-8-16(25(30)31)12-21(20)33(2)32)18-13-17(26)9-11-19(18)27-23(14)15-6-4-3-5-7-15/h3-13H,1-2H3,(H,28,29)(H,30,31)
UniProtKB/SwissProt

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UniChem
US Patent
n/an/a 720n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323728
PNG
(4-{[(6-Bromo-3-methyl-2-phenylquinolin-4-yl)carbon...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)Nc1ccc(C(O)=O)c(F)c1)-c1ccccc1
Show InChI InChI=1S/C24H16BrFN2O3/c1-13-21(23(29)27-16-8-9-17(24(30)31)19(26)12-16)18-11-15(25)7-10-20(18)28-22(13)14-5-3-2-4-6-14/h2-12H,1H3,(H,27,29)(H,30,31)
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US Patent
n/an/a 795n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323724
PNG
(5-{[(6-Bromo-3-methyl-2-phenylquinolin-4-yl)carbon...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)Nc1cnc(nc1)C(O)=O)-c1ccccc1
Show InChI InChI=1S/C22H15BrN4O3/c1-12-18(21(28)26-15-10-24-20(22(29)30)25-11-15)16-9-14(23)7-8-17(16)27-19(12)13-5-3-2-4-6-13/h2-11H,1H3,(H,26,28)(H,29,30)
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US Patent
n/an/a 880n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323749
PNG
(3-Fluoro-4-{[(6-fluoro-3-methyl-2-phenylquinolin-4...)
Show SMILES Cc1c(nc2ccc(F)cc2c1C(=O)Nc1ccc(cc1F)C(O)=O)-c1ccccc1
Show InChI InChI=1S/C24H16F2N2O3/c1-13-21(23(29)28-20-9-7-15(24(30)31)11-18(20)26)17-12-16(25)8-10-19(17)27-22(13)14-5-3-2-4-6-14/h2-12H,1H3,(H,28,29)(H,30,31)
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US Patent
n/an/a 890n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM323725
PNG
(5-{[(6-Bromo-3-methyl-2-phenylquinolin-4-yl)carbon...)
Show SMILES Cc1nc(ccc1NC(=O)c1c(C)c(nc2ccc(Br)cc12)-c1ccccc1)C(O)=O
Show InChI InChI=1S/C24H18BrN3O3/c1-13-21(23(29)28-18-10-11-20(24(30)31)26-14(18)2)17-12-16(25)8-9-19(17)27-22(13)15-6-4-3-5-7-15/h3-12H,1-2H3,(H,28,29)(H,30,31)
UniProtKB/SwissProt

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US Patent
n/an/a 905n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10189788 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%