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Patent code US10189807

Compile Data Set for Download or QSAR
Found 7 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Gamma-amino-N-butyrate transaminase


(Homo sapiens)
BDBM323799
PNG
((2S,4S)-4-Aminotetrahydrothiophene-2-carboxylic ac...)
Show SMILES N[C@@H]1CS[C@@H](C1)C(O)=O
Show InChI InChI=1S/C5H9NO2S/c6-3-1-4(5(7)8)9-2-3/h3-4H,1-2,6H2,(H,7,8)/t3-,4-/m0/s1
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PC cid
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UniChem
US Patent
1.82E+5n/an/an/an/an/an/an/an/a



Northwestern University

US Patent


Assay Description
Biochemical assays were performed using a Biotek Synergy H1 microplate reader. Prior to their evaluation, initial experiments were performed to confi...


US Patent US10189807 (2019)

More data for this
Ligand-Target Pair
Gamma-amino-N-butyrate transaminase


(Homo sapiens)
BDBM323800
PNG
((2R,4S)-4-Aminotetrahydrothiophene-2-carboxylic ac...)
Show SMILES N[C@@H]1CS[C@H](C1)C(O)=O
Show InChI InChI=1S/C5H9NO2S/c6-3-1-4(5(7)8)9-2-3/h3-4H,1-2,6H2,(H,7,8)/t3-,4+/m0/s1
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UniChem
US Patent
2.23E+6n/an/an/an/an/an/an/an/a



Northwestern University

US Patent


Assay Description
Biochemical assays were performed using a Biotek Synergy H1 microplate reader. Prior to their evaluation, initial experiments were performed to confi...


US Patent US10189807 (2019)

More data for this
Ligand-Target Pair
Gamma-amino-N-butyrate transaminase


(Homo sapiens)
BDBM50118886
PNG
(4-Amino-hex-5-enoic acid | CHEMBL89598 | US1018980...)
Show SMILES NC(CCC(O)=O)C=C
Show InChI InChI=1S/C6H11NO2/c1-2-5(7)3-4-6(8)9/h2,5H,1,3-4,7H2,(H,8,9)
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Patents


Similars

DrugBank
US Patent
3.20E+6n/an/an/an/an/an/an/an/a



Northwestern University

US Patent


Assay Description
Biochemical assays were performed using a Biotek Synergy H1 microplate reader. Prior to their evaluation, initial experiments were performed to confi...


US Patent US10189807 (2019)

More data for this
Ligand-Target Pair
Gamma-amino-N-butyrate transaminase


(Homo sapiens)
BDBM323801
PNG
((4S)-4-Aminotetrahydrothiophene-2-carboxylic acid ...)
Show SMILES [NH3+][C@H]1C[C@H](C([O-])=O)S(=O)(=O)C1
Show InChI InChI=1S/C5H9NO4S/c6-3-1-4(5(7)8)11(9,10)2-3/h3-4H,1-2,6H2,(H,7,8)/t3-,4+/m0/s1
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PC cid
PC sid
UniChem
US Patent
3.20E+6n/an/an/an/an/an/an/an/a



Northwestern University

US Patent


Assay Description
Biochemical assays were performed using a Biotek Synergy H1 microplate reader. Prior to their evaluation, initial experiments were performed to confi...


US Patent US10189807 (2019)

More data for this
Ligand-Target Pair
Gamma-amino-N-butyrate transaminase


(Homo sapiens)
BDBM323803
PNG
(US10189807, Compound 21)
Show SMILES [NH3+][C@H]1CS[C@@H](C1)C([O-])=O
Show InChI InChI=1S/C5H9NO2S/c6-3-1-4(5(7)8)9-2-3/h3-4H,1-2,6H2,(H,7,8)/t3-,4+/m1/s1
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UniChem
US Patent
3.30E+6n/an/an/an/an/an/an/an/a



Northwestern University

US Patent


Assay Description
Biochemical assays were performed using a Biotek Synergy H1 microplate reader. Prior to their evaluation, initial experiments were performed to confi...


US Patent US10189807 (2019)

More data for this
Ligand-Target Pair
Gamma-amino-N-butyrate transaminase


(Homo sapiens)
BDBM323802
PNG
(US10189807, Compound 20)
Show SMILES [NH3+][C@H]1CS[C@H](C1)C([O-])=O
Show InChI InChI=1S/C5H9NO2S/c6-3-1-4(5(7)8)9-2-3/h3-4H,1-2,6H2,(H,7,8)/t3-,4-/m1/s1
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UniChem
US Patent
3.40E+6n/an/an/an/an/an/an/an/a



Northwestern University

US Patent


Assay Description
Biochemical assays were performed using a Biotek Synergy H1 microplate reader. Prior to their evaluation, initial experiments were performed to confi...


US Patent US10189807 (2019)

More data for this
Ligand-Target Pair
Gamma-amino-N-butyrate transaminase


(Homo sapiens)
BDBM323805
PNG
(US10189807, Compound 22)
Show SMILES [NH3+][C@@H]1CC(C([O-])=O)S(=O)(=O)C1
Show InChI InChI=1S/C5H9NO4S/c6-3-1-4(5(7)8)11(9,10)2-3/h3-4H,1-2,6H2,(H,7,8)/t3-,4?/m1/s1
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UniChem
US Patent
7.50E+6n/an/an/an/an/an/an/an/a



Northwestern University

US Patent


Assay Description
Biochemical assays were performed using a Biotek Synergy H1 microplate reader. Prior to their evaluation, initial experiments were performed to confi...


US Patent US10189807 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%