BindingDB logo
myBDB logout

Patent code US10189809

Compile Data Set for Download or QSAR
Found 198 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323808
PNG
(US10189809, Compound I-26)
Show SMILES Fc1ccccc1Cn1nc(cc1-c1ccsc1)-c1ccccn1
Show InChI InChI=1S/C19H14FN3S/c20-16-6-2-1-5-14(16)12-23-19(15-8-10-24-13-15)11-18(22-23)17-7-3-4-9-21-17/h1-11,13H,12H2
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 8.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323815
PNG
(US10189809, Compound I-55)
Show SMILES Cc1cc(nn1Cc1ccccc1F)-c1ccccn1
Show InChI InChI=1S/C16H14FN3/c1-12-10-16(15-8-4-5-9-18-15)19-20(12)11-13-6-2-3-7-14(13)17/h2-10H,11H2,1H3
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 2.00E+5n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323832
PNG
(US10189809, Compound I-99)
Show SMILES COC(=O)Nc1c(N)nc(nc1N)-c1cc(-c2ncco2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C19H17FN8O3/c1-30-19(29)24-14-15(21)25-17(26-16(14)22)12-8-13(18-23-6-7-31-18)28(27-12)9-10-4-2-3-5-11(10)20/h2-8H,9H2,1H3,(H,24,29)(H4,21,22,25,26)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 3.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323833
PNG
(US10189809, Compound I-100)
Show SMILES COC(=O)N(C)c1c(N)nc(nc1N)-c1cc(-c2ncco2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C20H19FN8O3/c1-28(20(30)31-2)15-16(22)25-18(26-17(15)23)13-9-14(19-24-7-8-32-19)29(27-13)10-11-5-3-4-6-12(11)21/h3-9H,10H2,1-2H3,(H4,22,23,25,26)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 2.00E+5n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323839
PNG
(US10189809, Compound I-106)
Show SMILES CC(C)(C)OC(=O)Nc1cnc(nc1N)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C22H22FN7O3/c1-22(2,3)33-21(31)26-17-11-25-20(27-19(17)24)16-10-18(15-8-9-32-29-15)30(28-16)12-13-6-4-5-7-14(13)23/h4-11H,12H2,1-3H3,(H,26,31)(H2,24,25,27)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323847
PNG
(US10189809, Compound I-114)
Show SMILES CC(C)(C)c1cnc(nc1N)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C21H21FN6O/c1-21(2,3)14-11-24-20(25-19(14)23)17-10-18(16-8-9-29-27-16)28(26-17)12-13-6-4-5-7-15(13)22/h4-11H,12H2,1-3H3,(H2,23,24,25)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323850
PNG
(US10189809, Compound I-118)
Show SMILES Nc1nc(ncc1C1(CC1)OCC=C)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C23H21FN6O2/c1-2-10-31-23(8-9-23)16-13-26-22(27-21(16)25)19-12-20(18-7-11-32-29-18)30(28-19)14-15-5-3-4-6-17(15)24/h2-7,11-13H,1,8-10,14H2,(H2,25,26,27)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 8.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323852
PNG
(US10189809, Compound I-121)
Show SMILES Nc1nc(ncc1-c1ccsc1)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C21H15FN6OS/c22-16-4-2-1-3-13(16)11-28-19(17-5-7-29-27-17)9-18(26-28)21-24-10-15(20(23)25-21)14-6-8-30-12-14/h1-10,12H,11H2,(H2,23,24,25)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 3.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323863
PNG
(US10189809, Compound I-132)
Show SMILES Nc1nc(ncc1C(O)=O)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C18H13FN6O3/c19-12-4-2-1-3-10(12)9-25-15(13-5-6-28-24-13)7-14(23-25)17-21-8-11(18(26)27)16(20)22-17/h1-8H,9H2,(H,26,27)(H2,20,21,22)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 3.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323874
PNG
(US10189809, Compound I-267)
Show SMILES Fc1ccccc1Cn1nc(cc1-c1ccon1)-c1ncc(F)c(S)n1
Show InChI InChI=1S/C17H11F2N5OS/c18-11-4-2-1-3-10(11)9-24-15(13-5-6-25-23-13)7-14(22-24)16-20-8-12(19)17(26)21-16/h1-8H,9H2,(H,20,21,26)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323875
PNG
(US10189809, Compound I-266)
Show SMILES Oc1nc(ncc1Cl)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C17H11ClFN5O2/c18-11-8-20-16(21-17(11)25)14-7-15(13-5-6-26-23-13)24(22-14)9-10-3-1-2-4-12(10)19/h1-8H,9H2,(H,20,21,25)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323845
PNG
(US10189809, Compound I-112 | US10189809, Compound ...)
Show SMILES CC(=O)Nc1cnc(nc1N)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C19H16FN7O2/c1-11(28)23-16-9-22-19(24-18(16)21)15-8-17(14-6-7-29-26-14)27(25-15)10-12-4-2-3-5-13(12)20/h2-9H,10H2,1H3,(H,23,28)(H2,21,22,24)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323905
PNG
(US10189809, Compound I-233)
Show SMILES Nc1nc(ncc1NC(=O)C12CC3CC(CC(C3)C1)C2)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C28H28FN7O2/c29-20-4-2-1-3-19(20)15-36-24(21-5-6-38-35-21)10-22(34-36)26-31-14-23(25(30)33-26)32-27(37)28-11-16-7-17(12-28)9-18(8-16)13-28/h1-6,10,14,16-18H,7-9,11-13,15H2,(H,32,37)(H2,30,31,33)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323916
PNG
(US10189809, Compound I-224)
Show SMILES Oc1nc(ncc1S(=O)(=O)N1CCOCC1)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C21H19FN6O5S/c22-15-4-2-1-3-14(15)13-28-18(16-5-8-33-26-16)11-17(25-28)20-23-12-19(21(29)24-20)34(30,31)27-6-9-32-10-7-27/h1-5,8,11-12H,6-7,9-10,13H2,(H,23,24,29)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323929
PNG
(US10189809, Compound I-210)
Show SMILES OCCc1cnc(nc1O)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C19H16FN5O3/c20-14-4-2-1-3-13(14)11-25-17(15-6-8-28-24-15)9-16(23-25)18-21-10-12(5-7-26)19(27)22-18/h1-4,6,8-10,26H,5,7,11H2,(H,21,22,27)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 8.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323932
PNG
(US10189809, Compound I-207)
Show SMILES Oc1ccccc1Cn1nc(cc1-c1ccon1)-c1ncccn1
Show InChI InChI=1S/C17H13N5O2/c23-16-5-2-1-4-12(16)11-22-15(13-6-9-24-21-13)10-14(20-22)17-18-7-3-8-19-17/h1-10,23H,11H2
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.05E+6n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323933
PNG
(US10189809, Compound I-278)
Show SMILES CC1(CC1)C(=O)Nc1cnc(nc1O)-c1cc(-c2ncco2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C22H19FN6O3/c1-22(6-7-22)21(31)26-16-11-25-18(27-19(16)30)15-10-17(20-24-8-9-32-20)29(28-15)12-13-4-2-3-5-14(13)23/h2-5,8-11H,6-7,12H2,1H3,(H,26,31)(H,25,27,30)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323934
PNG
(US10189809, Compound I-206)
Show SMILES CC1(CC1)C(=O)Nc1cnc(nc1N)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C22H20FN7O2/c1-22(7-8-22)21(31)26-17-11-25-20(27-19(17)24)16-10-18(15-6-9-32-29-15)30(28-16)12-13-4-2-3-5-14(13)23/h2-6,9-11H,7-8,12H2,1H3,(H,26,31)(H2,24,25,27)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323935
PNG
(US10189809, Compound I-205)
Show SMILES CC(C)(F)C(=O)Nc1cnc(nc1N)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C21H19F2N7O2/c1-21(2,23)20(31)26-16-10-25-19(27-18(16)24)15-9-17(14-7-8-32-29-14)30(28-15)11-12-5-3-4-6-13(12)22/h3-10H,11H2,1-2H3,(H,26,31)(H2,24,25,27)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323940
PNG
(US10189809, Compound I-198)
Show SMILES Fc1cccc(Cn2nc(cc2-c2ccon2)-c2ncccn2)c1F
Show InChI InChI=1S/C17H11F2N5O/c18-12-4-1-3-11(16(12)19)10-24-15(13-5-8-25-23-13)9-14(22-24)17-20-6-2-7-21-17/h1-9H,10H2
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323943
PNG
(US10189809, Compound I-196)
Show SMILES CS(=O)(=O)c1cnc(nc1O)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C18H14FN5O4S/c1-29(26,27)16-9-20-17(21-18(16)25)14-8-15(13-6-7-28-23-13)24(22-14)10-11-4-2-3-5-12(11)19/h2-9H,10H2,1H3,(H,20,21,25)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323948
PNG
(US10189809, Compound I-191)
Show SMILES CC(C)(C)C(=O)Nc1cnc(nc1N)-c1cc(-c2ncco2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C22H22FN7O2/c1-22(2,3)21(31)27-16-11-26-19(28-18(16)24)15-10-17(20-25-8-9-32-20)30(29-15)12-13-6-4-5-7-14(13)23/h4-11H,12H2,1-3H3,(H,27,31)(H2,24,26,28)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323956
PNG
(US10189809, Compound I-183)
Show SMILES Cc1cccc(c1)C(=O)Nc1cnc(nc1N)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C25H20FN7O2/c1-15-5-4-7-16(11-15)25(34)29-21-13-28-24(30-23(21)27)20-12-22(19-9-10-35-32-19)33(31-20)14-17-6-2-3-8-18(17)26/h2-13H,14H2,1H3,(H,29,34)(H2,27,28,30)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323960
PNG
(US10189809, Compound I-179)
Show SMILES Nc1nc(ncc1NC(=O)c1cccnc1)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C23H17FN8O2/c24-16-6-2-1-4-15(16)13-32-20(17-7-9-34-31-17)10-18(30-32)22-27-12-19(21(25)29-22)28-23(33)14-5-3-8-26-11-14/h1-12H,13H2,(H,28,33)(H2,25,27,29)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323965
PNG
(US10189809, Compound I-174)
Show SMILES COc1cccc(c1)C(=O)Nc1cnc(nc1N)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C25H20FN7O3/c1-35-17-7-4-6-15(11-17)25(34)29-21-13-28-24(30-23(21)27)20-12-22(19-9-10-36-32-19)33(31-20)14-16-5-2-3-8-18(16)26/h2-13H,14H2,1H3,(H,29,34)(H2,27,28,30)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323982
PNG
(US10189809, Compound I-156)
Show SMILES COc1ccc(cc1)C(=O)Nc1cnc(nc1N)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C25H20FN7O3/c1-35-17-8-6-15(7-9-17)25(34)29-21-13-28-24(30-23(21)27)20-12-22(19-10-11-36-32-19)33(31-20)14-16-4-2-3-5-18(16)26/h2-13H,14H2,1H3,(H,29,34)(H2,27,28,30)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323994
PNG
(US10189809, Compound I-281)
Show SMILES Fc1ccccc1Cn1nc(cc1-c1ccon1)-c1ncc2[nH]c(=O)[nH]c2n1
Show InChI InChI=1S/C18H10FN7O2/c19-11-4-2-1-3-10(11)9-26-15(12-5-6-28-25-12)7-13(24-26)16-20-8-14-17(22-16)23-18(27)21-14/h1-8H,9H2
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 3.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323854
PNG
(US10189809, Compound I-125)
Show SMILES Nc1nc(ncc1NC(=O)OCc1ccccc1)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C25H20FN7O3/c26-18-9-5-4-8-17(18)14-33-22(19-10-11-36-32-19)12-20(31-33)24-28-13-21(23(27)30-24)29-25(34)35-15-16-6-2-1-3-7-16/h1-13H,14-15H2,(H,29,34)(H2,27,28,30)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323810
PNG
(US10189809, Compound I-33)
Show SMILES Fc1ccccc1Cn1nc(cc1-c1nccs1)-c1ncccn1
Show InChI InChI=1S/C17H12FN5S/c18-13-5-2-1-4-12(13)11-23-15(17-21-8-9-24-17)10-14(22-23)16-19-6-3-7-20-16/h1-10H,11H2
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 3.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323819
PNG
(US10189809, Compound I-71)
Show SMILES COC(=O)Nc1c(N)nc(nc1N)-c1cc(-c2ccsc2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C20H18FN7O2S/c1-30-20(29)24-16-17(22)25-19(26-18(16)23)14-8-15(12-6-7-31-10-12)28(27-14)9-11-4-2-3-5-13(11)21/h2-8,10H,9H2,1H3,(H,24,29)(H4,22,23,25,26)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 2.00E+5n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323834
PNG
(US10189809, Compound I-101)
Show SMILES Cn1c2c(N)nc(nc2[nH]c1=O)-c1cc(-c2ncco2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C19H15FN8O2/c1-27-14-15(21)23-16(24-17(14)25-19(27)29)12-8-13(18-22-6-7-30-18)28(26-12)9-10-4-2-3-5-11(10)20/h2-8H,9H2,1H3,(H3,21,23,24,25,29)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 5.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323843
PNG
(US10189809, Compound I-110)
Show SMILES Oc1nc(ncc1C#N)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C18H11FN6O2/c19-13-4-2-1-3-11(13)10-25-16(14-5-6-27-24-14)7-15(23-25)17-21-9-12(8-20)18(26)22-17/h1-7,9H,10H2,(H,21,22,26)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323844
PNG
(US10189809, Compound I-111)
Show SMILES Cc1cc(N)nc(n1)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C18H15FN6O/c1-11-8-17(20)22-18(21-11)15-9-16(14-6-7-26-24-14)25(23-15)10-12-4-2-3-5-13(12)19/h2-9H,10H2,1H3,(H2,20,21,22)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 3.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323851
PNG
(US10189809, Compound I-119)
Show SMILES Nc1nc(ncc1C1(O)CC1)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C20H17FN6O2/c21-14-4-2-1-3-12(14)11-27-17(15-5-8-29-26-15)9-16(25-27)19-23-10-13(18(22)24-19)20(28)6-7-20/h1-5,8-10,28H,6-7,11H2,(H2,22,23,24)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323867
PNG
(US10189809, Compound I-272)
Show SMILES Nc1nc(ncc1NC(=O)C1(CC1)C(F)(F)F)-c1cc(-c2ncco2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C22H17F4N7O2/c23-13-4-2-1-3-12(13)11-33-16(19-28-7-8-35-19)9-14(32-33)18-29-10-15(17(27)31-18)30-20(34)21(5-6-21)22(24,25)26/h1-4,7-10H,5-6,11H2,(H,30,34)(H2,27,29,31)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323870
PNG
(US10189809, Compound I-270)
Show SMILES CC(C)(C(=O)Nc1cnc(nc1N)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1)n1cncn1
Show InChI InChI=1S/C23H21FN10O2/c1-23(2,34-13-26-12-28-34)22(35)29-18-10-27-21(30-20(18)25)17-9-19(16-7-8-36-32-16)33(31-17)11-14-5-3-4-6-15(14)24/h3-10,12-13H,11H2,1-2H3,(H,29,35)(H2,25,27,30)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323881
PNG
(US10189809, Compound I-261)
Show SMILES Oc1cc(O)nc(n1)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C17H12FN5O3/c18-11-4-2-1-3-10(11)9-23-14(12-5-6-26-22-12)7-13(21-23)17-19-15(24)8-16(25)20-17/h1-8H,9H2,(H2,19,20,24,25)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 4.50E+5n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323882
PNG
(US10189809, Compound I-260)
Show SMILES CC1(CC1(Cl)Cl)C(=O)Nc1cnc(nc1N)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C22H18Cl2FN7O2/c1-21(11-22(21,23)24)20(33)28-16-9-27-19(29-18(16)26)15-8-17(14-6-7-34-31-14)32(30-15)10-12-4-2-3-5-13(12)25/h2-9H,10-11H2,1H3,(H,28,33)(H2,26,27,29)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323888
PNG
(US10189809, Compound I-249)
Show SMILES CN(C)\C=N\c1cnc(nc1)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C20H18FN7O/c1-27(2)13-24-15-10-22-20(23-11-15)18-9-19(17-7-8-29-26-17)28(25-18)12-14-5-3-4-6-16(14)21/h3-11,13H,12H2,1-2H3/b24-13+
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323900
PNG
(US10189809, Compound I-237)
Show SMILES Nc1nc(ncc1NC(=O)C1(CC1)C(F)(F)F)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C22H17F4N7O2/c23-13-4-2-1-3-12(13)11-33-17(14-5-8-35-32-14)9-15(31-33)19-28-10-16(18(27)30-19)29-20(34)21(6-7-21)22(24,25)26/h1-5,8-10H,6-7,11H2,(H,29,34)(H2,27,28,30)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323936
PNG
(US10189809, Compound I-203)
Show SMILES Cc1nc(nc(O)c1F)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C18H13F2N5O2/c1-10-16(20)18(26)22-17(21-10)14-8-15(13-6-7-27-24-13)25(23-14)9-11-4-2-3-5-12(11)19/h2-8H,9H2,1H3,(H,21,22,26)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 8.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323947
PNG
(US10189809, Compound I-192)
Show SMILES Oc1nc(ncc1Br)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C17H11BrFN5O2/c18-11-8-20-16(21-17(11)25)14-7-15(13-5-6-26-23-13)24(22-14)9-10-3-1-2-4-12(10)19/h1-8H,9H2,(H,20,21,25)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323951
PNG
(US10189809, Compound I-188)
Show SMILES Nc1nc(ncc1NC(=O)c1cnco1)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C21H15FN8O3/c22-13-4-2-1-3-12(13)10-30-17(14-5-6-33-29-14)7-15(28-30)20-25-8-16(19(23)27-20)26-21(31)18-9-24-11-32-18/h1-9,11H,10H2,(H,26,31)(H2,23,25,27)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323971
PNG
(US10189809, Compound I-168)
Show SMILES Nc1nc(ncc1NC(=O)c1ccc(F)cc1)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C24H17F2N7O2/c25-16-7-5-14(6-8-16)24(34)29-20-12-28-23(30-22(20)27)19-11-21(18-9-10-35-32-18)33(31-19)13-15-3-1-2-4-17(15)26/h1-12H,13H2,(H,29,34)(H2,27,28,30)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323987
PNG
(US10189809, Compound I-150)
Show SMILES CC(C)COC(=O)Nc1cnc(nc1N)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C22H22FN7O3/c1-13(2)12-32-22(31)26-18-10-25-21(27-20(18)24)17-9-19(16-7-8-33-29-16)30(28-17)11-14-5-3-4-6-15(14)23/h3-10,13H,11-12H2,1-2H3,(H,26,31)(H2,24,25,27)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323991
PNG
(US10189809, Compound I-312)
Show SMILES CC(C)(C)OC(=O)n1c2cnc(nc2[nH]c1=O)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C23H20FN7O4/c1-23(2,3)35-22(33)31-18-11-25-19(26-20(18)27-21(31)32)16-10-17(15-8-9-34-29-15)30(28-16)12-13-6-4-5-7-14(13)24/h4-11H,12H2,1-3H3,(H,25,26,27,32)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 5.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM324005
PNG
(US10189809, Compound I-293)
Show SMILES Fc1ccccc1Cn1nc(cc1C#N)-c1ncccn1
Show InChI InChI=1S/C15H10FN5/c16-13-5-2-1-4-11(13)10-21-12(9-17)8-14(20-21)15-18-6-3-7-19-15/h1-8H,10H2
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 5.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323807
PNG
(US10189809, Compound I-3)
Show SMILES Fc1ccccc1Cn1nc(cc1[N+]#[C-])-c1ccccn1
Show InChI InChI=1S/C16H11FN4/c1-18-16-10-15(14-8-4-5-9-19-14)20-21(16)11-12-6-2-3-7-13(12)17/h2-10H,11H2
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 3.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323816
PNG
(US10189809, Compound I-6)
Show SMILES COc1cccc(n1)-c1cc(nn1Cc1ccccc1F)-c1ncccn1
Show InChI InChI=1S/C20H16FN5O/c1-27-19-9-4-8-16(24-19)18-12-17(20-22-10-5-11-23-20)25-26(18)13-14-6-2-3-7-15(14)21/h2-12H,13H2,1H3
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 5.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323818
PNG
(US10189809, Compound I-66)
Show SMILES Fc1ccccc1Cn1nc(cc1-c1cccs1)-c1ncccn1
Show InChI InChI=1S/C18H13FN4S/c19-14-6-2-1-5-13(14)12-23-16(17-7-3-10-24-17)11-15(22-23)18-20-8-4-9-21-18/h1-11H,12H2
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 8.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323827
PNG
(US10189809, Compound I-92)
Show SMILES Nc1ccnc(n1)-c1cc(-c2cscn2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C17H13FN6S/c18-12-4-2-1-3-11(12)8-24-15(14-9-25-10-21-14)7-13(23-24)17-20-6-5-16(19)22-17/h1-7,9-10H,8H2,(H2,19,20,22)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 5.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323828
PNG
(US10189809, Compound I-93)
Show SMILES COC(=O)Nc1c(N)nc(nc1N)-c1cc(-c2nccs2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C19H17FN8O2S/c1-30-19(29)24-14-15(21)25-17(26-16(14)22)12-8-13(18-23-6-7-31-18)28(27-12)9-10-4-2-3-5-11(10)20/h2-8H,9H2,1H3,(H,24,29)(H4,21,22,25,26)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 2.00E+5n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323836
PNG
(US10189809, Compound I-103)
Show SMILES Nc1cc(N)nc(n1)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C17H14FN7O/c18-11-4-2-1-3-10(11)9-25-14(12-5-6-26-24-12)7-13(23-25)17-21-15(19)8-16(20)22-17/h1-8H,9H2,(H4,19,20,21,22)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 5.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323840
PNG
(US10189809, Compound I-107)
Show SMILES Nc1cnc(nc1N)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C17H14FN7O/c18-11-4-2-1-3-10(11)9-25-15(13-5-6-26-24-13)7-14(23-25)17-21-8-12(19)16(20)22-17/h1-8H,9,19H2,(H2,20,21,22)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323841
PNG
(US10189809, Compound I-108)
Show SMILES Nc1nc(ncc1-c1nccs1)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C20H14FN7OS/c21-14-4-2-1-3-12(14)11-28-17(15-5-7-29-27-15)9-16(26-28)19-24-10-13(18(22)25-19)20-23-6-8-30-20/h1-10H,11H2,(H2,22,24,25)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 2.00E+5n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323856
PNG
(US10189809, Compound I-127)
Show SMILES Nc1nc(ncc1-c1cccnc1)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C22H16FN7O/c23-17-6-2-1-4-15(17)13-30-20(18-7-9-31-29-18)10-19(28-30)22-26-12-16(21(24)27-22)14-5-3-8-25-11-14/h1-12H,13H2,(H2,24,26,27)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323858
PNG
(US10189809, Compound I-128)
Show SMILES Nc1nc(ncc1-c1ccccn1)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C22H16FN7O/c23-16-6-2-1-5-14(16)13-30-20(18-8-10-31-29-18)11-19(28-30)22-26-12-15(21(24)27-22)17-7-3-4-9-25-17/h1-12H,13H2,(H2,24,26,27)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 3.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323862
PNG
(US10189809, Compound I-131)
Show SMILES CCOC(=O)c1cnc(nc1N)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C20H17FN6O3/c1-2-29-20(28)13-10-23-19(24-18(13)22)16-9-17(15-7-8-30-26-15)27(25-16)11-12-5-3-4-6-14(12)21/h3-10H,2,11H2,1H3,(H2,22,23,24)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 2.00E+5n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323871
PNG
(US10189809, Compound I-282)
Show SMILES Oc1nc(nc(O)c1[N+]([O-])=O)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C17H11FN6O5/c18-10-4-2-1-3-9(10)8-23-13(11-5-6-29-22-11)7-12(21-23)15-19-16(25)14(24(27)28)17(26)20-15/h1-7H,8H2,(H2,19,20,25,26)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.05E+6n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323879
PNG
(US10189809, Compound I-277 | US10189809, Compound ...)
Show SMILES CC(C)(C)C(=O)Nc1cnc(nc1N)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C22H22FN7O2/c1-22(2,3)21(31)26-17-11-25-20(27-19(17)24)16-10-18(15-8-9-32-29-15)30(28-16)12-13-6-4-5-7-14(13)23/h4-11H,12H2,1-3H3,(H,26,31)(H2,24,25,27)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323886
PNG
(US10189809, Compound I-251)
Show SMILES CC(C)(C)S(=O)(=O)Nc1cnc(nc1N)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C21H22FN7O3S/c1-21(2,3)33(30,31)28-17-11-24-20(25-19(17)23)16-10-18(15-8-9-32-27-15)29(26-16)12-13-6-4-5-7-14(13)22/h4-11,28H,12H2,1-3H3,(H2,23,24,25)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 3.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323887
PNG
(US10189809, Compound I-250)
Show SMILES CC(C)(C)S(=O)Nc1cnc(nc1NS(=O)C(C)(C)C)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C25H30FN7O3S2/c1-24(2,3)37(34)31-20-14-27-22(28-23(20)32-38(35)25(4,5)6)19-13-21(18-11-12-36-30-18)33(29-19)15-16-9-7-8-10-17(16)26/h7-14,31H,15H2,1-6H3,(H,27,28,32)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 2.00E+5n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323889
PNG
(US10189809, Compound I-248)
Show SMILES Oc1cc(=O)c2c(O)nc(nc2o1)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C20H12FN5O5/c21-11-4-2-1-3-10(11)9-26-14(12-5-6-30-25-12)7-13(24-26)18-22-19(29)17-15(27)8-16(28)31-20(17)23-18/h1-8,28H,9H2,(H,22,23,29)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 7.50E+5n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323910
PNG
(US10189809, Compound I-229)
Show SMILES CO[C@@](C(=O)Nc1cnc(nc1N)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1)(c1ccccc1)C(F)(F)F
Show InChI InChI=1S/C27H21F4N7O3/c1-40-26(27(29,30)31,17-8-3-2-4-9-17)25(39)34-21-14-33-24(35-23(21)32)20-13-22(19-11-12-41-37-19)38(36-20)15-16-7-5-6-10-18(16)28/h2-14H,15H2,1H3,(H,34,39)(H2,32,33,35)/t26-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 3.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323944
PNG
(US10189809, Compound I-195)
Show SMILES Fc1ccccc1Cn1nc(cc1-c1ccon1)-c1ncccn1
Show InChI InChI=1S/C17H12FN5O/c18-13-5-2-1-4-12(13)11-23-16(14-6-9-24-22-14)10-15(21-23)17-19-7-3-8-20-17/h1-10H,11H2
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323954
PNG
(US10189809, Compound I-185)
Show SMILES Nc1nc(ncc1NC(=O)c1ccccc1Cl)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C24H17ClFN7O2/c25-16-7-3-2-6-15(16)24(34)29-20-12-28-23(30-22(20)27)19-11-21(18-9-10-35-32-18)33(31-19)13-14-5-1-4-8-17(14)26/h1-12H,13H2,(H,29,34)(H2,27,28,30)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323958
PNG
(US10189809, Compound I-181)
Show SMILES Cc1ccc(cc1)C(=O)Nc1cnc(nc1N)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C25H20FN7O2/c1-15-6-8-16(9-7-15)25(34)29-21-13-28-24(30-23(21)27)20-12-22(19-10-11-35-32-19)33(31-20)14-17-4-2-3-5-18(17)26/h2-13H,14H2,1H3,(H,29,34)(H2,27,28,30)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323963
PNG
(US10189809, Compound I-176)
Show SMILES Nc1nc(ncc1NC(=O)c1ccncc1)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C23H17FN8O2/c24-16-4-2-1-3-15(16)13-32-20(17-7-10-34-31-17)11-18(30-32)22-27-12-19(21(25)29-22)28-23(33)14-5-8-26-9-6-14/h1-12H,13H2,(H,28,33)(H2,25,27,29)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323972
PNG
(US10189809, Compound I-167)
Show SMILES Nc1nc(ncc1NC(=O)CCCCl)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C21H19ClFN7O2/c22-8-3-6-19(31)26-17-11-25-21(27-20(17)24)16-10-18(15-7-9-32-29-15)30(28-16)12-13-4-1-2-5-14(13)23/h1-2,4-5,7,9-11H,3,6,8,12H2,(H,26,31)(H2,24,25,27)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323980
PNG
(US10189809, Compound I-160)
Show SMILES Oc1ccnc(n1)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C17H12FN5O2/c18-12-4-2-1-3-11(12)10-23-15(13-6-8-25-22-13)9-14(21-23)17-19-7-5-16(24)20-17/h1-9H,10H2,(H,19,20,24)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323990
PNG
(US10189809, Compound I-147)
Show SMILES Nc1nc(ncc1F)-c1cc(-c2ncco2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C17H12F2N6O/c18-11-4-2-1-3-10(11)9-25-14(17-21-5-6-26-17)7-13(24-25)16-22-8-12(19)15(20)23-16/h1-8H,9H2,(H2,20,22,23)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM324002
PNG
(US10189809, Compound I-296)
Show SMILES Nc1ccnc(n1)-c1cc(-c2cnco2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C17H13FN6O/c18-12-4-2-1-3-11(12)9-24-14(15-8-20-10-25-15)7-13(23-24)17-21-6-5-16(19)22-17/h1-8,10H,9H2,(H2,19,21,22)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323809
PNG
(US10189809, Compound I-27)
Show SMILES Fc1ccccc1Cn1nc(cc1-c1nccs1)-c1ccccn1
Show InChI InChI=1S/C18H13FN4S/c19-14-6-2-1-5-13(14)12-23-17(18-21-9-10-24-18)11-16(22-23)15-7-3-4-8-20-15/h1-11H,12H2
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 3.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323820
PNG
(US10189809, Compound I-72)
Show SMILES COC(=O)N(C)c1c(N)nc(nc1N)-c1cc(-c2ccsc2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C21H20FN7O2S/c1-28(21(30)31-2)17-18(23)25-20(26-19(17)24)15-9-16(13-7-8-32-11-13)29(27-15)10-12-5-3-4-6-14(12)22/h3-9,11H,10H2,1-2H3,(H4,23,24,25,26)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 3.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323821
PNG
(US10189809, Compound I-75)
Show SMILES Fc1ccccc1Cn1nc(cc1-c1ccccn1)-c1ncccn1
Show InChI InChI=1S/C19H14FN5/c20-15-7-2-1-6-14(15)13-25-18(16-8-3-4-9-21-16)12-17(24-25)19-22-10-5-11-23-19/h1-12H,13H2
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 5.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323829
PNG
(US10189809, Compound I-96)
Show SMILES Cn1c2c(N)nc(nc2[nH]c1=O)-c1cc(-c2nccs2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C19H15FN8OS/c1-27-14-15(21)23-16(24-17(14)25-19(27)29)12-8-13(18-22-6-7-30-18)28(26-12)9-10-4-2-3-5-11(10)20/h2-8H,9H2,1H3,(H3,21,23,24,25,29)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323837
PNG
(US10189809, Compound I-104)
Show SMILES Nc1nc(ncc1C1CC1)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C20H17FN6O/c21-15-4-2-1-3-13(15)11-27-18(16-7-8-28-26-16)9-17(25-27)20-23-10-14(12-5-6-12)19(22)24-20/h1-4,7-10,12H,5-6,11H2,(H2,22,23,24)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323842
PNG
(US10189809, Compound I-109)
Show SMILES Nc1nc(ncc1F)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C17H12F2N6O/c18-11-4-2-1-3-10(11)9-25-15(13-5-6-26-24-13)7-14(23-25)17-21-8-12(19)16(20)22-17/h1-8H,9H2,(H2,20,21,22)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323846
PNG
(US10189809, Compound I-113)
Show SMILES Nc1nc(ncc1C(F)(F)F)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C18H12F4N6O/c19-12-4-2-1-3-10(12)9-28-15(13-5-6-29-27-13)7-14(26-28)17-24-8-11(16(23)25-17)18(20,21)22/h1-8H,9H2,(H2,23,24,25)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 8.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323848
PNG
(US10189809, Compound I-115)
Show SMILES CN(C(=O)OC(C)(C)C)c1cnc(nc1N)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C23H24FN7O3/c1-23(2,3)34-22(32)30(4)19-12-26-21(27-20(19)25)17-11-18(16-9-10-33-29-16)31(28-17)13-14-7-5-6-8-15(14)24/h5-12H,13H2,1-4H3,(H2,25,26,27)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323854
PNG
(US10189809, Compound I-125)
Show SMILES Nc1nc(ncc1NC(=O)OCc1ccccc1)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C25H20FN7O3/c26-18-9-5-4-8-17(18)14-33-22(19-10-11-36-32-19)12-20(31-33)24-28-13-21(23(27)30-24)29-25(34)35-15-16-6-2-1-3-7-16/h1-13H,14-15H2,(H,29,34)(H2,27,28,30)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323855
PNG
(US10189809, Compound I-126)
Show SMILES Nc1nc(ncc1NC(=O)c1ccccc1)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C24H18FN7O2/c25-17-9-5-4-8-16(17)14-32-21(18-10-11-34-31-18)12-19(30-32)23-27-13-20(22(26)29-23)28-24(33)15-6-2-1-3-7-15/h1-13H,14H2,(H,28,33)(H2,26,27,29)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323877
PNG
(US10189809, Compound I-264)
Show SMILES CC(C)(C)C(=O)Nc1cnc(nc1)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C22H21FN6O2/c1-22(2,3)21(30)26-15-11-24-20(25-12-15)18-10-19(17-8-9-31-28-17)29(27-18)13-14-6-4-5-7-16(14)23/h4-12H,13H2,1-3H3,(H,26,30)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 4.50E+5n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323883
PNG
(US10189809, Compound I-259)
Show SMILES Nc1nc(ncc1N1Cc2ccccc2C1=O)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C25H18FN7O2/c26-18-8-4-2-6-16(18)14-33-21(19-9-10-35-31-19)11-20(30-33)24-28-12-22(23(27)29-24)32-13-15-5-1-3-7-17(15)25(32)34/h1-12H,13-14H2,(H2,27,28,29)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323891
PNG
(US10189809, Compound I-246)
Show SMILES CC(C)(C=C)C(=O)Nc1cnc(nc1N)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C23H22FN7O2/c1-4-23(2,3)22(32)27-18-12-26-21(28-20(18)25)17-11-19(16-9-10-33-30-16)31(29-17)13-14-7-5-6-8-15(14)24/h4-12H,1,13H2,2-3H3,(H,27,32)(H2,25,26,28)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323892
PNG
(US10189809, Compound I-245)
Show SMILES CC1(CC1(F)F)C(=O)Nc1cnc(nc1N)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C22H18F3N7O2/c1-21(11-22(21,24)25)20(33)28-16-9-27-19(29-18(16)26)15-8-17(14-6-7-34-31-14)32(30-15)10-12-4-2-3-5-13(12)23/h2-9H,10-11H2,1H3,(H,28,33)(H2,26,27,29)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323893
PNG
(US10189809, Compound I-244)
Show SMILES Nc1nc(ncc1NC(=O)C(F)(F)c1ccccc1)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C25H18F3N7O2/c26-17-9-5-4-6-15(17)14-35-21(18-10-11-37-34-18)12-19(33-35)23-30-13-20(22(29)32-23)31-24(36)25(27,28)16-7-2-1-3-8-16/h1-13H,14H2,(H,31,36)(H2,29,30,32)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 3.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323896
PNG
(US10189809, Compound I-241)
Show SMILES Oc1nc(ncc1S(=O)(=O)c1ccc(F)cc1)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C23H15F2N5O4S/c24-15-5-7-16(8-6-15)35(32,33)21-12-26-22(27-23(21)31)19-11-20(18-9-10-34-29-18)30(28-19)13-14-3-1-2-4-17(14)25/h1-12H,13H2,(H,26,27,31)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323899
PNG
(US10189809, Compound I-238)
Show SMILES Nc1nc(ncc1NC(=O)C1(CC1)[N+]#[C-])-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C22H17FN8O2/c1-25-22(7-8-22)21(32)27-17-11-26-20(28-19(17)24)16-10-18(15-6-9-33-30-15)31(29-16)12-13-4-2-3-5-14(13)23/h2-6,9-11H,7-8,12H2,(H,27,32)(H2,24,26,28)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323901
PNG
(US10189809, Compound I-236)
Show SMILES CC(C)(C(=O)Nc1cnc(nc1N)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1)c1ccccc1
Show InChI InChI=1S/C27H24FN7O2/c1-27(2,18-9-4-3-5-10-18)26(36)31-22-15-30-25(32-24(22)29)21-14-23(20-12-13-37-34-20)35(33-21)16-17-8-6-7-11-19(17)28/h3-15H,16H2,1-2H3,(H,31,36)(H2,29,30,32)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323903
PNG
(US10189809, Compound I-234)
Show SMILES CN(C(=O)C(C)(C)C)c1cnc(nc1N)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C23H24FN7O2/c1-23(2,3)22(32)30(4)19-12-26-21(27-20(19)25)17-11-18(16-9-10-33-29-16)31(28-17)13-14-7-5-6-8-15(14)24/h5-12H,13H2,1-4H3,(H2,25,26,27)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323909
PNG
(US10189809, Compound I-230)
Show SMILES CC(C)(Oc1ccccc1)C(=O)Nc1cnc(nc1N)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C27H24FN7O3/c1-27(2,38-18-9-4-3-5-10-18)26(36)31-22-15-30-25(32-24(22)29)21-14-23(20-12-13-37-34-20)35(33-21)16-17-8-6-7-11-19(17)28/h3-15H,16H2,1-2H3,(H,31,36)(H2,29,30,32)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 8.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323920
PNG
(US10189809, Compound I-219)
Show SMILES Nc1nc(ncc1NC(=O)[C@@H]1CCCN1C(=O)C(F)(F)F)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C24H20F4N8O3/c25-14-5-2-1-4-13(14)12-36-19(15-7-9-39-34-15)10-16(33-36)21-30-11-17(20(29)32-21)31-22(37)18-6-3-8-35(18)23(38)24(26,27)28/h1-2,4-5,7,9-11,18H,3,6,8,12H2,(H,31,37)(H2,29,30,32)/t18-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323922
PNG
(US10189809, Compound I-217)
Show SMILES Oc1nc(ncc1S(=O)(=O)c1ccccc1)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C23H16FN5O4S/c24-17-9-5-4-6-15(17)14-29-20(18-10-11-33-28-18)12-19(27-29)22-25-13-21(23(30)26-22)34(31,32)16-7-2-1-3-8-16/h1-13H,14H2,(H,25,26,30)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323930
PNG
(US10189809, Compound I-209)
Show SMILES CC(C)(O)C(=O)Nc1cnc(nc1N)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C21H20FN7O3/c1-21(2,31)20(30)25-16-10-24-19(26-18(16)23)15-9-17(14-7-8-32-28-14)29(27-15)11-12-5-3-4-6-13(12)22/h3-10,31H,11H2,1-2H3,(H,25,30)(H2,23,24,26)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 3.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323931
PNG
(US10189809, Compound I-208)
Show SMILES C(c1cncnc1)n1nc(cc1-c1ccon1)-c1ncccn1
Show InChI InChI=1S/C15H11N7O/c1-3-18-15(19-4-1)13-6-14(12-2-5-23-21-12)22(20-13)9-11-7-16-10-17-8-11/h1-8,10H,9H2
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 2.00E+5n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323955
PNG
(US10189809, Compound I-184)
Show SMILES Cc1ccccc1C(=O)Nc1cnc(nc1N)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C25H20FN7O2/c1-15-6-2-4-8-17(15)25(34)29-21-13-28-24(30-23(21)27)20-12-22(19-10-11-35-32-19)33(31-20)14-16-7-3-5-9-18(16)26/h2-13H,14H2,1H3,(H,29,34)(H2,27,28,30)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323957
PNG
(US10189809, Compound I-182)
Show SMILES Nc1nc(ncc1NC(=O)c1ccc(Cl)cc1)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C24H17ClFN7O2/c25-16-7-5-14(6-8-16)24(34)29-20-12-28-23(30-22(20)27)19-11-21(18-9-10-35-32-18)33(31-19)13-15-3-1-2-4-17(15)26/h1-12H,13H2,(H,29,34)(H2,27,28,30)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323962
PNG
(US10189809, Compound I-177)
Show SMILES COCC(=O)Nc1cnc(nc1N)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C20H18FN7O3/c1-30-11-18(29)24-16-9-23-20(25-19(16)22)15-8-17(14-6-7-31-27-14)28(26-15)10-12-4-2-3-5-13(12)21/h2-9H,10-11H2,1H3,(H,24,29)(H2,22,23,25)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323984
PNG
(US10189809, Compound I-153)
Show SMILES Nc1nc(ncc1N1CCOC1=O)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C20H16FN7O3/c21-13-4-2-1-3-12(13)11-28-16(14-5-7-31-26-14)9-15(25-28)19-23-10-17(18(22)24-19)27-6-8-30-20(27)29/h1-5,7,9-10H,6,8,11H2,(H2,22,23,24)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323879
PNG
(US10189809, Compound I-277 | US10189809, Compound ...)
Show SMILES CC(C)(C)C(=O)Nc1cnc(nc1N)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C22H22FN7O2/c1-22(2,3)21(31)26-17-11-25-20(27-19(17)24)16-10-18(15-8-9-32-29-15)30(28-16)12-13-6-4-5-7-14(13)23/h4-11H,12H2,1-3H3,(H,26,31)(H2,24,25,27)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323811
PNG
(US10189809, Compound I-42)
Show SMILES Fc1ccccc1Cn1nc(cc1C1CCC1)-c1ccccn1
Show InChI InChI=1S/C19H18FN3/c20-16-9-2-1-6-15(16)13-23-19(14-7-5-8-14)12-18(22-23)17-10-3-4-11-21-17/h1-4,6,9-12,14H,5,7-8,13H2
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 2.00E+5n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323813
PNG
(US10189809, Compound I-4)
Show SMILES Fc1ccccc1Cn1nc(cc1-c1ccsc1)-c1ncccn1
Show InChI InChI=1S/C18H13FN4S/c19-15-5-2-1-4-13(15)11-23-17(14-6-9-24-12-14)10-16(22-23)18-20-7-3-8-21-18/h1-10,12H,11H2
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 8.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323814
PNG
(US10189809, Compound I-49)
Show SMILES Nc1ccnc(n1)-c1cc(-c2ccsc2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C18H14FN5S/c19-14-4-2-1-3-12(14)10-24-16(13-6-8-25-11-13)9-15(23-24)18-21-7-5-17(20)22-18/h1-9,11H,10H2,(H2,20,21,22)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM50175274
PNG
(CHEMBL3809864 | US10189809, Compound I-97)
Show SMILES Nc1ccnc(n1)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C17H13FN6O/c18-12-4-2-1-3-11(12)10-24-15(13-6-8-25-23-13)9-14(22-24)17-20-7-5-16(19)21-17/h1-9H,10H2,(H2,19,20,21)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323849
PNG
(US10189809, Compound I-116)
Show SMILES Nc1cc(nc(n1)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1)-c1cccnc1
Show InChI InChI=1S/C22H16FN7O/c23-16-6-2-1-4-15(16)13-30-20(17-7-9-31-29-17)10-19(28-30)22-26-18(11-21(24)27-22)14-5-3-8-25-12-14/h1-12H,13H2,(H2,24,26,27)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 3.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323853
PNG
(US10189809, Compound I-122)
Show SMILES Nc1nc(ncc1-c1ccccc1)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C23H17FN6O/c24-18-9-5-4-8-16(18)14-30-21(19-10-11-31-29-19)12-20(28-30)23-26-13-17(22(25)27-23)15-6-2-1-3-7-15/h1-13H,14H2,(H2,25,26,27)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 3.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323865
PNG
(US10189809, Compound I-137)
Show SMILES COc1ccc(cc1)C1=Nc2nc(ncc2C(C)(C)O1)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C28H23FN6O3/c1-28(2)20-15-30-26(31-25(20)32-27(38-28)17-8-10-19(36-3)11-9-17)23-14-24(22-12-13-37-34-22)35(33-23)16-18-6-4-5-7-21(18)29/h4-15H,16H2,1-3H3
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 5.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323866
PNG
(US10189809, Compound I-139)
Show SMILES Nc1nc(ncc1N1CCOCC1)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C21H20FN7O2/c22-15-4-2-1-3-14(15)13-29-18(16-5-8-31-27-16)11-17(26-29)21-24-12-19(20(23)25-21)28-6-9-30-10-7-28/h1-5,8,11-12H,6-7,9-10,13H2,(H2,23,24,25)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323869
PNG
(US10189809, Compound I-271)
Show SMILES Oc1nc(ncc1S(=O)(=O)c1ccccc1)-c1cc(-c2ncco2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C23H16FN5O4S/c24-17-9-5-4-6-15(17)14-29-19(23-25-10-11-33-23)12-18(28-29)21-26-13-20(22(30)27-21)34(31,32)16-7-2-1-3-8-16/h1-13H,14H2,(H,26,27,30)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323873
PNG
(US10189809, Compound I-268)
Show SMILES CC(C)(CCl)C(=O)Nc1cnc(nc1N)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C22H21ClFN7O2/c1-22(2,12-23)21(32)27-17-10-26-20(28-19(17)25)16-9-18(15-7-8-33-30-15)31(29-16)11-13-5-3-4-6-14(13)24/h3-10H,11-12H2,1-2H3,(H,27,32)(H2,25,26,28)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323880
PNG
(US10189809, Compound I-262)
Show SMILES Nc1cnc(nc1)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C17H13FN6O/c18-13-4-2-1-3-11(13)10-24-16(14-5-6-25-23-14)7-15(22-24)17-20-8-12(19)9-21-17/h1-9H,10,19H2
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323897
PNG
(US10189809, Compound I-240)
Show SMILES CC(C)=CC(=O)Nc1cnc(nc1N)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C22H20FN7O2/c1-13(2)9-20(31)26-18-11-25-22(27-21(18)24)17-10-19(16-7-8-32-29-16)30(28-17)12-14-5-3-4-6-15(14)23/h3-11H,12H2,1-2H3,(H,26,31)(H2,24,25,27)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323906
PNG
(US10189809, Compound I-232)
Show SMILES CC1(CCCO1)C(=O)Nc1cnc(nc1N)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C23H22FN7O3/c1-23(8-4-9-33-23)22(32)27-18-12-26-21(28-20(18)25)17-11-19(16-7-10-34-30-16)31(29-17)13-14-5-2-3-6-15(14)24/h2-3,5-7,10-12H,4,8-9,13H2,1H3,(H,27,32)(H2,25,26,28)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323908
PNG
(US10189809, Compound I-231)
Show SMILES CC1(CCCCC1)C(=O)Nc1cnc(nc1N)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C25H26FN7O2/c1-25(10-5-2-6-11-25)24(34)29-20-14-28-23(30-22(20)27)19-13-21(18-9-12-35-32-18)33(31-19)15-16-7-3-4-8-17(16)26/h3-4,7-9,12-14H,2,5-6,10-11,15H2,1H3,(H,29,34)(H2,27,28,30)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323917
PNG
(US10189809, Compound I-223)
Show SMILES Nc1nc(ncc1NCc1ccccc1)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C24H20FN7O/c25-18-9-5-4-8-17(18)15-32-22(19-10-11-33-31-19)12-20(30-32)24-28-14-21(23(26)29-24)27-13-16-6-2-1-3-7-16/h1-12,14,27H,13,15H2,(H2,26,28,29)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 2.00E+5n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323926
PNG
(US10189809, Compound I-213)
Show SMILES NCC(=O)Nc1cnc(nc1N)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C19H17FN8O2/c20-12-4-2-1-3-11(12)10-28-16(13-5-6-30-27-13)7-14(26-28)19-23-9-15(18(22)25-19)24-17(29)8-21/h1-7,9H,8,10,21H2,(H,24,29)(H2,22,23,25)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 8.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323927
PNG
(US10189809, Compound I-212)
Show SMILES Nc1nc(ncc1NC(=O)CN1C(=O)c2ccccc2C1=O)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C27H19FN8O4/c28-18-8-4-1-5-15(18)13-36-22(19-9-10-40-34-19)11-20(33-36)25-30-12-21(24(29)32-25)31-23(37)14-35-26(38)16-6-2-3-7-17(16)27(35)39/h1-12H,13-14H2,(H,31,37)(H2,29,30,32)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323928
PNG
(US10189809, Compound I-211)
Show SMILES Nc1nc(ncc1NC(=O)c1ccccc1OC(F)(F)F)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C25H17F4N7O3/c26-16-7-3-1-5-14(16)13-36-20(17-9-10-38-35-17)11-18(34-36)23-31-12-19(22(30)33-23)32-24(37)15-6-2-4-8-21(15)39-25(27,28)29/h1-12H,13H2,(H,32,37)(H2,30,31,33)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 3.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323941
PNG
(US10189809, Compound I-197)
Show SMILES Oc1nc(ncc1F)-c1cc(-c2ncco2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C17H11F2N5O2/c18-11-4-2-1-3-10(11)9-24-14(17-20-5-6-26-17)7-13(23-24)15-21-8-12(19)16(25)22-15/h1-8H,9H2,(H,21,22,25)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 3.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323946
PNG
(US10189809, Compound I-193)
Show SMILES Nc1nc(ncc1NC(=O)c1cccc(O)n1)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C23H17FN8O3/c24-14-5-2-1-4-13(14)12-32-19(15-8-9-35-31-15)10-17(30-32)22-26-11-18(21(25)29-22)28-23(34)16-6-3-7-20(33)27-16/h1-11H,12H2,(H,27,33)(H,28,34)(H2,25,26,29)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323950
PNG
(US10189809, Compound I-189)
Show SMILES Nc1nc(ncc1NC(=O)c1nccs1)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C21H15FN8O2S/c22-13-4-2-1-3-12(13)11-30-17(14-5-7-32-29-14)9-15(28-30)19-25-10-16(18(23)27-19)26-20(31)21-24-6-8-33-21/h1-10H,11H2,(H,26,31)(H2,23,25,27)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323952
PNG
(US10189809, Compound I-187)
Show SMILES Nc1nc(ncc1NC(=O)c1cccc(Cl)c1)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C24H17ClFN7O2/c25-16-6-3-5-14(10-16)24(34)29-20-12-28-23(30-22(20)27)19-11-21(18-8-9-35-32-18)33(31-19)13-15-4-1-2-7-17(15)26/h1-12H,13H2,(H,29,34)(H2,27,28,30)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323953
PNG
(US10189809, Compound I-186)
Show SMILES Nc1nc(ncc1NC(=O)c1ccccc1)-c1cc(-c2ncco2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C24H18FN7O2/c25-17-9-5-4-8-16(17)14-32-20(24-27-10-11-34-24)12-18(31-32)22-28-13-19(21(26)30-22)29-23(33)15-6-2-1-3-7-15/h1-13H,14H2,(H,29,33)(H2,26,28,30)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323964
PNG
(US10189809, Compound I-175)
Show SMILES Nc1nc(ncc1NC(=O)c1ccon1)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C21H15FN8O3/c22-13-4-2-1-3-12(13)11-30-18(14-5-7-32-28-14)9-16(27-30)20-24-10-17(19(23)26-20)25-21(31)15-6-8-33-29-15/h1-10H,11H2,(H,25,31)(H2,23,24,26)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323966
PNG
(US10189809, Compound I-173)
Show SMILES COc1cnc(nc1N)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C18H15FN6O2/c1-26-16-9-21-18(22-17(16)20)14-8-15(13-6-7-27-24-13)25(23-14)10-11-4-2-3-5-12(11)19/h2-9H,10H2,1H3,(H2,20,21,22)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 2.00E+5n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323977
PNG
(US10189809, Compound I-161)
Show SMILES Oc1nc(ncc1F)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C17H11F2N5O2/c18-11-4-2-1-3-10(11)9-24-15(13-5-6-26-23-13)7-14(22-24)16-20-8-12(19)17(25)21-16/h1-8H,9H2,(H,20,21,25)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323983
PNG
(US10189809, Compound I-155)
Show SMILES Oc1nc(ncc1C#N)-c1cc(-c2ncco2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C18H11FN6O2/c19-13-4-2-1-3-11(13)10-25-15(18-21-5-6-27-18)7-14(24-25)16-22-9-12(8-20)17(26)23-16/h1-7,9H,10H2,(H,22,23,26)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323989
PNG
(US10189809, Compound I-148)
Show SMILES CC(C)(C)OC(=O)Nc1cnc(nc1N)-c1cc(-c2ncco2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C22H22FN7O3/c1-22(2,3)33-21(31)27-16-11-26-19(28-18(16)24)15-10-17(20-25-8-9-32-20)30(29-15)12-13-6-4-5-7-14(13)23/h4-11H,12H2,1-3H3,(H,27,31)(H2,24,26,28)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323855
PNG
(US10189809, Compound I-126)
Show SMILES Nc1nc(ncc1NC(=O)c1ccccc1)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C24H18FN7O2/c25-17-9-5-4-8-16(17)14-32-21(18-10-11-34-31-18)12-19(30-32)23-27-13-20(22(26)29-23)28-24(33)15-6-2-1-3-7-15/h1-13H,14H2,(H,28,33)(H2,26,27,29)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323851
PNG
(US10189809, Compound I-119)
Show SMILES Nc1nc(ncc1C1(O)CC1)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C20H17FN6O2/c21-14-4-2-1-3-12(14)11-27-17(15-5-8-29-26-15)9-16(25-27)19-23-10-13(18(22)24-19)20(28)6-7-20/h1-5,8-10,28H,6-7,11H2,(H2,22,23,24)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323806
PNG
(US10189809, Compound I-1)
Show SMILES Fc1ccccc1Cn1nc(cc1-c1ccccn1)-c1ccccn1
Show InChI InChI=1S/C20H15FN4/c21-16-8-2-1-7-15(16)14-25-20(18-10-4-6-12-23-18)13-19(24-25)17-9-3-5-11-22-17/h1-13H,14H2
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 2.00E+5n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323823
PNG
(US10189809, Compound I-84)
Show SMILES COC(=O)N(C)c1c(N)nc(nc1N)-c1cc(-c2ccccc2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C23H22FN7O2/c1-30(23(32)33-2)19-20(25)27-22(28-21(19)26)17-12-18(14-8-4-3-5-9-14)31(29-17)13-15-10-6-7-11-16(15)24/h3-12H,13H2,1-2H3,(H4,25,26,27,28)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 5.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323825
PNG
(US10189809, Compound I-86)
Show SMILES Nc1ccnc(n1)-c1cc(-c2nccs2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C17H13FN6S/c18-12-4-2-1-3-11(12)10-24-14(17-21-7-8-25-17)9-13(23-24)16-20-6-5-15(19)22-16/h1-9H,10H2,(H2,19,20,22)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323831
PNG
(US10189809, Compound I-98)
Show SMILES Nc1ccnc(n1)-c1cc(-c2cocn2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C17H13FN6O/c18-12-4-2-1-3-11(12)8-24-15(14-9-25-10-21-14)7-13(23-24)17-20-6-5-16(19)22-17/h1-7,9-10H,8H2,(H2,19,20,22)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323835
PNG
(US10189809, Compound I-102)
Show SMILES Nc1nc(ncc1-c1ccncc1)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C22H16FN7O/c23-17-4-2-1-3-15(17)13-30-20(18-7-10-31-29-18)11-19(28-30)22-26-12-16(21(24)27-22)14-5-8-25-9-6-14/h1-12H,13H2,(H2,24,26,27)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323838
PNG
(US10189809, Compound I-105)
Show SMILES COC(=O)N(C)c1cnc(nc1N)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C20H18FN7O3/c1-27(20(29)30-2)17-10-23-19(24-18(17)22)15-9-16(14-7-8-31-26-14)28(25-15)11-12-5-3-4-6-13(12)21/h3-10H,11H2,1-2H3,(H2,22,23,24)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323864
PNG
(US10189809, Compound I-133)
Show SMILES CC(C)(O)c1cnc(nc1O)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C20H18FN5O3/c1-20(2,28)13-10-22-18(23-19(13)27)16-9-17(15-7-8-29-25-15)26(24-16)11-12-5-3-4-6-14(12)21/h3-10,28H,11H2,1-2H3,(H,22,23,27)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323872
PNG
(US10189809, Compound I-269)
Show SMILES Nc1nc(ncc1N=C(c1ccccc1)c1ccccc1)-c1cc(-c2ncco2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C30H22FN7O/c31-23-14-8-7-13-22(23)19-38-26(30-33-15-16-39-30)17-24(37-38)29-34-18-25(28(32)36-29)35-27(20-9-3-1-4-10-20)21-11-5-2-6-12-21/h1-18H,19H2,(H2,32,34,36)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 2.00E+5n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323884
PNG
(US10189809, Compound I-258)
Show SMILES CC(=C)C(=O)Nc1cnc(nc1N)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C21H18FN7O2/c1-12(2)21(30)25-17-10-24-20(26-19(17)23)16-9-18(15-7-8-31-28-15)29(27-16)11-13-5-3-4-6-14(13)22/h3-10H,1,11H2,2H3,(H,25,30)(H2,23,24,26)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323890
PNG
(US10189809, Compound I-247)
Show SMILES CCC(C)(C)C(=O)Nc1cnc(nc1N)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C23H24FN7O2/c1-4-23(2,3)22(32)27-18-12-26-21(28-20(18)25)17-11-19(16-9-10-33-30-16)31(29-17)13-14-7-5-6-8-15(14)24/h5-12H,4,13H2,1-3H3,(H,27,32)(H2,25,26,28)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323913
PNG
(US10189809, Compound I-227)
Show SMILES C\C=C(/C)C(=O)Nc1cnc(nc1N)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C22H20FN7O2/c1-3-13(2)22(31)26-18-11-25-21(27-20(18)24)17-10-19(16-8-9-32-29-16)30(28-17)12-14-6-4-5-7-15(14)23/h3-11H,12H2,1-2H3,(H,26,31)(H2,24,25,27)/b13-3+
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323915
PNG
(US10189809, Compound I-225)
Show SMILES Nc1nc(ncc1NC(=O)[C@@H]1CCCN1)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C22H21FN8O2/c23-14-5-2-1-4-13(14)12-31-19(15-7-9-33-30-15)10-17(29-31)21-26-11-18(20(24)28-21)27-22(32)16-6-3-8-25-16/h1-2,4-5,7,9-11,16,25H,3,6,8,12H2,(H,27,32)(H2,24,26,28)/t16-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 8.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323918
PNG
(US10189809, Compound I-222)
Show SMILES CN(C)c1ccccc1C(=O)Nc1cnc(nc1N)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C26H23FN8O2/c1-34(2)22-10-6-4-8-17(22)26(36)30-21-14-29-25(31-24(21)28)20-13-23(19-11-12-37-33-19)35(32-20)15-16-7-3-5-9-18(16)27/h3-14H,15H2,1-2H3,(H,30,36)(H2,28,29,31)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 5.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323923
PNG
(US10189809, Compound I-216)
Show SMILES Oc1nc(ncc1C(F)(F)F)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C18H11F4N5O2/c19-12-4-2-1-3-10(12)9-27-15(13-5-6-29-26-13)7-14(25-27)16-23-8-11(17(28)24-16)18(20,21)22/h1-8H,9H2,(H,23,24,28)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323937
PNG
(US10189809, Compound I-202)
Show SMILES Fc1cccc(Cn2nc(cc2-c2ccon2)-c2ncccn2)c1
Show InChI InChI=1S/C17H12FN5O/c18-13-4-1-3-12(9-13)11-23-16(14-5-8-24-22-14)10-15(21-23)17-19-6-2-7-20-17/h1-10H,11H2
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323945
PNG
(US10189809, Compound I-194)
Show SMILES CCOC(=O)c1cnc(nc1O)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C20H16FN5O4/c1-2-29-20(28)13-10-22-18(23-19(13)27)16-9-17(15-7-8-30-25-15)26(24-16)11-12-5-3-4-6-14(12)21/h3-10H,2,11H2,1H3,(H,22,23,27)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 3.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323961
PNG
(US10189809, Compound I-178)
Show SMILES Nc1nc(ncc1Nc1nccs1)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C20H15FN8OS/c21-13-4-2-1-3-12(13)11-29-17(14-5-7-30-28-14)9-15(27-29)19-24-10-16(18(22)26-19)25-20-23-6-8-31-20/h1-10H,11H2,(H,23,25)(H2,22,24,26)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323968
PNG
(US10189809, Compound I-172)
Show SMILES Nc1nc(ncc1NC(=O)c1ccccc1F)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C24H17F2N7O2/c25-16-7-3-1-5-14(16)13-33-21(18-9-10-35-32-18)11-19(31-33)23-28-12-20(22(27)30-23)29-24(34)15-6-2-4-8-17(15)26/h1-12H,13H2,(H,29,34)(H2,27,28,30)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323970
PNG
(US10189809, Compound I-169)
Show SMILES Nc1nc(ncc1N1CCCC1=O)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C21H18FN7O2/c22-14-5-2-1-4-13(14)12-29-17(15-7-9-31-27-15)10-16(26-29)21-24-11-18(20(23)25-21)28-8-3-6-19(28)30/h1-2,4-5,7,9-11H,3,6,8,12H2,(H2,23,24,25)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323975
PNG
(US10189809, Compound I-165)
Show SMILES CC(C)C(=O)Nc1cnc(nc1N)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C21H20FN7O2/c1-12(2)21(30)25-17-10-24-20(26-19(17)23)16-9-18(15-7-8-31-28-15)29(27-16)11-13-5-3-4-6-14(13)22/h3-10,12H,11H2,1-2H3,(H,25,30)(H2,23,24,26)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323976
PNG
(US10189809, Compound I-162)
Show SMILES Nc1nc(ncc1NC(=O)c1ccccn1)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C23H17FN8O2/c24-15-6-2-1-5-14(15)13-32-20(16-8-10-34-31-16)11-18(30-32)22-27-12-19(21(25)29-22)28-23(33)17-7-3-4-9-26-17/h1-12H,13H2,(H,28,33)(H2,25,27,29)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323981
PNG
(US10189809, Compound I-158)
Show SMILES Oc1nc(ncc1NC(=O)c1ccccc1)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C24H17FN6O3/c25-17-9-5-4-8-16(17)14-31-21(18-10-11-34-30-18)12-19(29-31)22-26-13-20(24(33)28-22)27-23(32)15-6-2-1-3-7-15/h1-13H,14H2,(H,27,32)(H,26,28,33)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 2.00E+5n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323997
PNG
(US10189809, Compound I-124)
Show SMILES CC(C)(C)CC(=O)Nc1cnc(nc1N)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C23H24FN7O2/c1-23(2,3)11-20(32)27-18-12-26-22(28-21(18)25)17-10-19(16-8-9-33-30-16)31(29-17)13-14-6-4-5-7-15(14)24/h4-10,12H,11,13H2,1-3H3,(H,27,32)(H2,25,26,28)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM324006
PNG
(US10189809, Compound I-306)
Show SMILES Fc1ccccc1Cn1nc(cc1-c1ccco1)-c1ncccn1
Show InChI InChI=1S/C18H13FN4O/c19-14-6-2-1-5-13(14)12-23-16(17-7-3-10-24-17)11-15(22-23)18-20-8-4-9-21-18/h1-11H,12H2
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM324007
PNG
(US10189809, Compound I-304)
Show SMILES Fc1ccccc1Cn1nc(cc1-c1ncon1)-c1ccccn1
Show InChI InChI=1S/C17H12FN5O/c18-13-6-2-1-5-12(13)10-23-16(17-20-11-24-22-17)9-15(21-23)14-7-3-4-8-19-14/h1-9,11H,10H2
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 3.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323817
PNG
(US10189809, Compound I-61)
Show SMILES Fc1ccccc1Cn1nc(cc1-c1ccco1)-c1ccccn1
Show InChI InChI=1S/C19H14FN3O/c20-15-7-2-1-6-14(15)13-23-18(19-9-5-11-24-19)12-17(22-23)16-8-3-4-10-21-16/h1-12H,13H2
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 5.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323822
PNG
(US10189809, Compound I-83)
Show SMILES COC(=O)Nc1c(N)nc(nc1N)-c1cc(-c2ccccc2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C22H20FN7O2/c1-32-22(31)26-18-19(24)27-21(28-20(18)25)16-11-17(13-7-3-2-4-8-13)30(29-16)12-14-9-5-6-10-15(14)23/h2-11H,12H2,1H3,(H,26,31)(H4,24,25,27,28)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 2.00E+5n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323859
PNG
(US10189809, Compound I-129)
Show SMILES Nc1nc(ncc1N1CCCC1)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C21H20FN7O/c22-15-6-2-1-5-14(15)13-29-18(16-7-10-30-27-16)11-17(26-29)21-24-12-19(20(23)25-21)28-8-3-4-9-28/h1-2,5-7,10-12H,3-4,8-9,13H2,(H2,23,24,25)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323868
PNG
(US10189809, Compound I-274)
Show SMILES CN(C)C(=O)Oc1cnc(nc1)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C20H17FN6O3/c1-26(2)20(28)30-14-10-22-19(23-11-14)17-9-18(16-7-8-29-25-16)27(24-17)12-13-5-3-4-6-15(13)21/h3-11H,12H2,1-2H3
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323876
PNG
(US10189809, Compound I-265)
Show SMILES CC(C)(CO)C(=O)Nc1cnc(nc1N)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C22H22FN7O3/c1-22(2,12-31)21(32)26-17-10-25-20(27-19(17)24)16-9-18(15-7-8-33-29-15)30(28-16)11-13-5-3-4-6-14(13)23/h3-10,31H,11-12H2,1-2H3,(H,26,32)(H2,24,25,27)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323885
PNG
(US10189809, Compound I-252)
Show SMILES CCCC(F)(F)C(=O)Nc1cnc(nc1N)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C22H20F3N7O2/c1-2-8-22(24,25)21(33)28-17-11-27-20(29-19(17)26)16-10-18(15-7-9-34-31-15)32(30-16)12-13-5-3-4-6-14(13)23/h3-7,9-11H,2,8,12H2,1H3,(H,28,33)(H2,26,27,29)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323894
PNG
(US10189809, Compound I-243)
Show SMILES Nc1nc(ncc1NC(=O)C1(CCC1)C(F)(F)F)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C23H19F4N7O2/c24-14-5-2-1-4-13(14)12-34-18(15-6-9-36-33-15)10-16(32-34)20-29-11-17(19(28)31-20)30-21(35)22(7-3-8-22)23(25,26)27/h1-2,4-6,9-11H,3,7-8,12H2,(H,30,35)(H2,28,29,31)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323895
PNG
(US10189809, Compound I-242)
Show SMILES Oc1nc(ncc1S(=O)(=O)c1cc(Cl)ccc1Cl)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C23H14Cl2FN5O4S/c24-14-5-6-15(25)20(9-14)36(33,34)21-11-27-22(28-23(21)32)18-10-19(17-7-8-35-30-17)31(29-18)12-13-3-1-2-4-16(13)26/h1-11H,12H2,(H,27,28,32)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 8.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323911
PNG
(US10189809, Compound I-228)
Show SMILES CN(C(=O)c1ccccc1)c1cnc(nc1N)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C25H20FN7O2/c1-32(25(34)16-7-3-2-4-8-16)22-14-28-24(29-23(22)27)20-13-21(19-11-12-35-31-19)33(30-20)15-17-9-5-6-10-18(17)26/h2-14H,15H2,1H3,(H2,27,28,29)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 3.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323914
PNG
(US10189809, Compound I-226)
Show SMILES CC(F)(F)C(=O)Nc1cnc(nc1N)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C20H16F3N7O2/c1-20(22,23)19(31)26-15-9-25-18(27-17(15)24)14-8-16(13-6-7-32-29-13)30(28-14)10-11-4-2-3-5-12(11)21/h2-9H,10H2,1H3,(H,26,31)(H2,24,25,27)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323919
PNG
(US10189809, Compound I-220)
Show SMILES Cc1cccc(C)c1C(=O)Nc1cnc(nc1N)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C26H22FN7O2/c1-15-6-5-7-16(2)23(15)26(35)30-21-13-29-25(31-24(21)28)20-12-22(19-10-11-36-33-19)34(32-20)14-17-8-3-4-9-18(17)27/h3-13H,14H2,1-2H3,(H,30,35)(H2,28,29,31)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323921
PNG
(US10189809, Compound I-218)
Show SMILES Nc1nc(ncc1NC(=O)C1(CCC1)c1ccccc1)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C28H24FN7O2/c29-20-10-5-4-7-18(20)17-36-24(21-11-14-38-35-21)15-22(34-36)26-31-16-23(25(30)33-26)32-27(37)28(12-6-13-28)19-8-2-1-3-9-19/h1-5,7-11,14-16H,6,12-13,17H2,(H,32,37)(H2,30,31,33)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 3.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323924
PNG
(US10189809, Compound I-215)
Show SMILES Nc1nc(ncc1NC(=O)c1cccc(c1)C(F)(F)F)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C25H17F4N7O2/c26-17-7-2-1-4-15(17)13-36-21(18-8-9-38-35-18)11-19(34-36)23-31-12-20(22(30)33-23)32-24(37)14-5-3-6-16(10-14)25(27,28)29/h1-12H,13H2,(H,32,37)(H2,30,31,33)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323938
PNG
(US10189809, Compound I-200)
Show SMILES Clc1ccccc1Cn1nc(cc1-c1ccon1)-c1ncccn1
Show InChI InChI=1S/C17H12ClN5O/c18-13-5-2-1-4-12(13)11-23-16(14-6-9-24-22-14)10-15(21-23)17-19-7-3-8-20-17/h1-10H,11H2
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 4.50E+5n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323939
PNG
(US10189809, Compound I-199)
Show SMILES Fc1cccc(F)c1Cn1nc(cc1-c1ccon1)-c1ncccn1
Show InChI InChI=1S/C17H11F2N5O/c18-12-3-1-4-13(19)11(12)10-24-16(14-5-8-25-23-14)9-15(22-24)17-20-6-2-7-21-17/h1-9H,10H2
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 3.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323949
PNG
(US10189809, Compound I-190)
Show SMILES Nc1nc(ncc1NC(=O)c1cscn1)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C21H15FN8O2S/c22-13-4-2-1-3-12(13)9-30-18(14-5-6-32-29-14)7-15(28-30)20-24-8-16(19(23)27-20)26-21(31)17-10-33-11-25-17/h1-8,10-11H,9H2,(H,26,31)(H2,23,24,27)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323973
PNG
(US10189809, Compound I-166)
Show SMILES COc1ccccc1C(=O)Nc1cnc(nc1N)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C25H20FN7O3/c1-35-22-9-5-3-7-16(22)25(34)29-20-13-28-24(30-23(20)27)19-12-21(18-10-11-36-32-18)33(31-19)14-15-6-2-4-8-17(15)26/h2-13H,14H2,1H3,(H,29,34)(H2,27,28,30)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323985
PNG
(US10189809, Compound I-152)
Show SMILES Nc1nc(ncc1NC(=O)OCCCl)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C20H17ClFN7O3/c21-6-8-31-20(30)25-16-10-24-19(26-18(16)23)15-9-17(14-5-7-32-28-14)29(27-15)11-12-3-1-2-4-13(12)22/h1-5,7,9-10H,6,8,11H2,(H,25,30)(H2,23,24,26)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323992
PNG
(US10189809, Compound I-144)
Show SMILES Nc1nc(ncc1NC(=O)C1CC1)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C21H18FN7O2/c22-14-4-2-1-3-13(14)11-29-18(15-7-8-31-28-15)9-16(27-29)20-24-10-17(19(23)26-20)25-21(30)12-5-6-12/h1-4,7-10,12H,5-6,11H2,(H,25,30)(H2,23,24,26)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323865
PNG
(US10189809, Compound I-137)
Show SMILES COc1ccc(cc1)C1=Nc2nc(ncc2C(C)(C)O1)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C28H23FN6O3/c1-28(2)20-15-30-26(31-25(20)32-27(38-28)17-8-10-19(36-3)11-9-17)23-14-24(22-12-13-37-34-22)35(33-23)16-18-6-4-5-7-21(18)29/h4-15H,16H2,1-3H3
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 5.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323995
PNG
(US10189809, Compound I-143)
Show SMILES CNc1cnc(nc1N)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C18H16FN7O/c1-21-15-9-22-18(23-17(15)20)14-8-16(13-6-7-27-25-13)26(24-14)10-11-4-2-3-5-12(11)19/h2-9,21H,10H2,1H3,(H2,20,22,23)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 5.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323998
PNG
(US10189809, Compound I-136)
Show SMILES CC(C)(C)NC(=O)c1cnc(nc1N)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C22H22FN7O2/c1-22(2,3)27-21(31)14-11-25-20(26-19(14)24)17-10-18(16-8-9-32-29-16)30(28-17)12-13-6-4-5-7-15(13)23/h4-11H,12H2,1-3H3,(H,27,31)(H2,24,25,26)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM324000
PNG
(US10189809, Compound I-299)
Show SMILES Cc1cc(Cl)nc(n1)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C18H13ClFN5O/c1-11-8-17(19)22-18(21-11)15-9-16(14-6-7-26-24-14)25(23-15)10-12-4-2-3-5-13(12)20/h2-9H,10H2,1H3
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM324001
PNG
(US10189809, Compound I-297)
Show SMILES Cc1cnc(nc1N)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C18H15FN6O/c1-11-9-21-18(22-17(11)20)15-8-16(14-6-7-26-24-14)25(23-15)10-12-4-2-3-5-13(12)19/h2-9H,10H2,1H3,(H2,20,21,22)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM324008
PNG
(US10189809, Compound I-309)
Show SMILES Fc1ccccc1Cn1nc(cc1-c1ncco1)-c1ncccn1
Show InChI InChI=1S/C17H12FN5O/c18-13-5-2-1-4-12(13)11-23-15(17-21-8-9-24-17)10-14(22-23)16-19-6-3-7-20-16/h1-10H,11H2
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323812
PNG
(US10189809, Compound I-45)
Show SMILES Fc1ccccc1Cn1nc(cc1-c1nnco1)-c1ccccn1
Show InChI InChI=1S/C17H12FN5O/c18-13-6-2-1-5-12(13)10-23-16(17-21-20-11-24-17)9-15(22-23)14-7-3-4-8-19-14/h1-9,11H,10H2
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 8.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323824
PNG
(US10189809, Compound I-85)
Show SMILES Fc1ccccc1Cn1nc(cc1-c1cscn1)-c1ncccn1
Show InChI InChI=1S/C17H12FN5S/c18-13-5-2-1-4-12(13)9-23-16(15-10-24-11-21-15)8-14(22-23)17-19-6-3-7-20-17/h1-8,10-11H,9H2
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323826
PNG
(US10189809, Compound I-87)
Show SMILES Nc1ccnc(n1)-c1cc(-c2ncco2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C17H13FN6O/c18-12-4-2-1-3-11(12)10-24-14(17-21-7-8-25-17)9-13(23-24)16-20-6-5-15(19)22-16/h1-9H,10H2,(H2,19,20,22)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323845
PNG
(US10189809, Compound I-112 | US10189809, Compound ...)
Show SMILES CC(=O)Nc1cnc(nc1N)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C19H16FN7O2/c1-11(28)23-16-9-22-19(24-18(16)21)15-8-17(14-6-7-29-26-14)27(25-15)10-12-4-2-3-5-13(12)20/h2-9H,10H2,1H3,(H,23,28)(H2,21,22,24)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323861
PNG
(US10189809, Compound I-130)
Show SMILES Nc1nc(ncc1C#N)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C18H12FN7O/c19-13-4-2-1-3-11(13)10-26-16(14-5-6-27-25-14)7-15(24-26)18-22-9-12(8-20)17(21)23-18/h1-7,9H,10H2,(H2,21,22,23)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323898
PNG
(US10189809, Compound I-239)
Show SMILES Nc1nc(ncc1NC(=O)\C=C\c1ccccc1)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C26H20FN7O2/c27-19-9-5-4-8-18(19)16-34-23(20-12-13-36-33-20)14-21(32-34)26-29-15-22(25(28)31-26)30-24(35)11-10-17-6-2-1-3-7-17/h1-15H,16H2,(H,30,35)(H2,28,29,31)/b11-10+
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323902
PNG
(US10189809, Compound I-235)
Show SMILES Nc1nc(ncc1NC(=O)C1CC2CC1C=C2)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C25H22FN7O2/c26-18-4-2-1-3-16(18)13-33-22(19-7-8-35-32-19)11-20(31-33)24-28-12-21(23(27)30-24)29-25(34)17-10-14-5-6-15(17)9-14/h1-8,11-12,14-15,17H,9-10,13H2,(H,29,34)(H2,27,28,30)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323925
PNG
(US10189809, Compound I-214)
Show SMILES Nc1nc(ncc1NC(=O)c1cccc(OC(F)(F)F)c1)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C25H17F4N7O3/c26-17-7-2-1-4-15(17)13-36-21(18-8-9-38-35-18)11-19(34-36)23-31-12-20(22(30)33-23)32-24(37)14-5-3-6-16(10-14)39-25(27,28)29/h1-12H,13H2,(H,32,37)(H2,30,31,33)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323959
PNG
(US10189809, Compound I-180)
Show SMILES Nc1nc(ncc1NC(=O)c1cocn1)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C21H15FN8O3/c22-13-4-2-1-3-12(13)9-30-18(14-5-6-33-29-14)7-15(28-30)20-24-8-16(19(23)27-20)26-21(31)17-10-32-11-25-17/h1-8,10-11H,9H2,(H,26,31)(H2,23,24,27)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323969
PNG
(US10189809, Compound I-171)
Show SMILES Nc1nc(ncc1NC(=O)c1cccc(F)c1)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C24H17F2N7O2/c25-16-6-3-5-14(10-16)24(34)29-20-12-28-23(30-22(20)27)19-11-21(18-8-9-35-32-18)33(31-19)13-15-4-1-2-7-17(15)26/h1-12H,13H2,(H,29,34)(H2,27,28,30)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323986
PNG
(US10189809, Compound I-151)
Show SMILES CC(=O)Nc1cnc(nc1N)-c1cc(-c2ncco2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C19H16FN7O2/c1-11(28)24-15-9-23-18(25-17(15)21)14-8-16(19-22-6-7-29-19)27(26-14)10-12-4-2-3-5-13(12)20/h2-9H,10H2,1H3,(H,24,28)(H2,21,23,25)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323988
PNG
(US10189809, Compound I-149)
Show SMILES Nc1cnc(nc1N)-c1cc(-c2ncco2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C17H14FN7O/c18-11-4-2-1-3-10(11)9-25-14(17-21-5-6-26-17)7-13(24-25)16-22-8-12(19)15(20)23-16/h1-8H,9,19H2,(H2,20,22,23)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 3.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323996
PNG
(US10189809, Compound I-142)
Show SMILES COC(=O)Nc1cnc(nc1N)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C19H16FN7O3/c1-29-19(28)23-15-9-22-18(24-17(15)21)14-8-16(13-6-7-30-26-13)27(25-14)10-11-4-2-3-5-12(11)20/h2-9H,10H2,1H3,(H,23,28)(H2,21,22,24)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323850
PNG
(US10189809, Compound I-118)
Show SMILES Nc1nc(ncc1C1(CC1)OCC=C)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C23H21FN6O2/c1-2-10-31-23(8-9-23)16-13-26-22(27-21(16)25)19-12-20(18-7-11-32-29-18)30(28-19)14-15-5-3-4-6-17(15)24/h2-7,11-13H,1,8-10,14H2,(H2,25,26,27)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 8.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM323999
PNG
(US10189809, Compound I-301)
Show SMILES Fc1ccccc1Cn1nc(cc1-c1ccon1)-c1nc(Cl)cc(n1)-c1cccnc1
Show InChI InChI=1S/C22H14ClFN6O/c23-21-11-18(14-5-3-8-25-12-14)26-22(27-21)19-10-20(17-7-9-31-29-17)30(28-19)13-15-4-1-2-6-16(15)24/h1-12H,13H2
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<2.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM324003
PNG
(US10189809, Compound I-295)
Show SMILES Oc1coc(n1)-c1cc(nn1Cc1ccccc1F)-c1ncccn1
Show InChI InChI=1S/C17H12FN5O2/c18-12-5-2-1-4-11(12)9-23-14(17-21-15(24)10-25-17)8-13(22-23)16-19-6-3-7-20-16/h1-8,10,24H,9H2
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 5.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM324004
PNG
(US10189809, Compound I-294)
Show SMILES Cc1csc(n1)-c1cc(nn1Cc1ccccc1F)-c1ncccn1
Show InChI InChI=1S/C18H14FN5S/c1-12-11-25-18(22-12)16-9-15(17-20-7-4-8-21-17)23-24(16)10-13-5-2-3-6-14(13)19/h2-9,11H,10H2,1H3
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 5.00E+4n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10189809 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%