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Patent code US10189816

Compile Data Set for Download or QSAR
Found 194 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324011
PNG
(US10189816, Compound 4)
Show SMILES Cc1ccccc1CN1CCc2cc(ccc2C1)-c1c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c1N1CCC(C)(C)CC1
Show InChI InChI=1S/C37H49N3O3/c1-24-11-9-10-12-29(24)22-39-18-15-27-21-28(13-14-30(27)23-39)31-25(2)38-26(3)32(34(35(41)42)43-36(4,5)6)33(31)40-19-16-37(7,8)17-20-40/h9-14,21,34H,15-20,22-23H2,1-8H3,(H,41,42)/t34-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324013
PNG
(US10189816, Compound 6)
Show SMILES COc1cccc(CN2CCc3cc(ccc3C2)-c2c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c2N2CCC(C)(C)CC2)c1
Show InChI InChI=1S/C37H49N3O4/c1-24-31(28-12-13-29-23-39(17-14-27(29)21-28)22-26-10-9-11-30(20-26)43-8)33(40-18-15-37(6,7)16-19-40)32(25(2)38-24)34(35(41)42)44-36(3,4)5/h9-13,20-21,34H,14-19,22-23H2,1-8H3,(H,41,42)/t34-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324025
PNG
(US10189816, Compound 18)
Show SMILES Cc1ccc(CN2CCc3cc(ccc3C2)-c2c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c2N2CCC(C)(C)CC2)cc1F
Show InChI InChI=1S/C37H48FN3O3/c1-23-9-10-26(19-30(23)38)21-40-16-13-27-20-28(11-12-29(27)22-40)31-24(2)39-25(3)32(34(35(42)43)44-36(4,5)6)33(31)41-17-14-37(7,8)15-18-41/h9-12,19-20,34H,13-18,21-22H2,1-8H3,(H,42,43)/t34-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324034
PNG
(US10189816, Compound 27)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4ccc(cc4)C(C)(C)C)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C40H55N3O3/c1-26-33(30-13-14-31-25-42(20-17-29(31)23-30)24-28-11-15-32(16-12-28)38(3,4)5)35(43-21-18-40(9,10)19-22-43)34(27(2)41-26)36(37(44)45)46-39(6,7)8/h11-16,23,36H,17-22,24-25H2,1-10H3,(H,44,45)/t36-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324039
PNG
(US10189816, Compound 32)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4cccc(c4F)C(F)(F)F)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C37H45F4N3O3/c1-22-29(32(44-17-14-36(6,7)15-18-44)30(23(2)42-22)33(34(45)46)47-35(3,4)5)25-11-12-26-20-43(16-13-24(26)19-25)21-27-9-8-10-28(31(27)38)37(39,40)41/h8-12,19,33H,13-18,20-21H2,1-7H3,(H,45,46)/t33-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324041
PNG
(US10189816, Compound 34)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4cc(F)c(F)c(F)c4)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C36H44F3N3O3/c1-21-29(25-8-9-26-20-41(13-10-24(26)18-25)19-23-16-27(37)31(39)28(38)17-23)32(42-14-11-36(6,7)12-15-42)30(22(2)40-21)33(34(43)44)45-35(3,4)5/h8-9,16-18,33H,10-15,19-20H2,1-7H3,(H,43,44)/t33-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324045
PNG
(US10189816, Compound 38)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4cc(F)ccc4F)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C36H45F2N3O3/c1-22-30(25-8-9-26-20-40(15-12-24(26)18-25)21-27-19-28(37)10-11-29(27)38)32(41-16-13-36(6,7)14-17-41)31(23(2)39-22)33(34(42)43)44-35(3,4)5/h8-11,18-19,33H,12-17,20-21H2,1-7H3,(H,42,43)/t33-/m0/s1
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n/an/an/an/a 6n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324050
PNG
(US10189816, Compound 43)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4cc(F)cc(Cl)c4)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C36H45ClFN3O3/c1-22-30(26-8-9-27-21-40(13-10-25(27)18-26)20-24-16-28(37)19-29(38)17-24)32(41-14-11-36(6,7)12-15-41)31(23(2)39-22)33(34(42)43)44-35(3,4)5/h8-9,16-19,33H,10-15,20-21H2,1-7H3,(H,42,43)/t33-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324051
PNG
(US10189816, Compound 44)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4c(F)ccc(F)c4F)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C36H44F3N3O3/c1-21-29(24-8-9-25-19-41(15-12-23(25)18-24)20-26-27(37)10-11-28(38)31(26)39)32(42-16-13-36(6,7)14-17-42)30(22(2)40-21)33(34(43)44)45-35(3,4)5/h8-11,18,33H,12-17,19-20H2,1-7H3,(H,43,44)/t33-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324069
PNG
(US10189816, Compound 62)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4ccccc4C#N)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C37H46N4O3/c1-24-31(27-12-13-30-23-40(17-14-26(30)20-27)22-29-11-9-8-10-28(29)21-38)33(41-18-15-37(6,7)16-19-41)32(25(2)39-24)34(35(42)43)44-36(3,4)5/h8-13,20,34H,14-19,22-23H2,1-7H3,(H,42,43)/t34-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324074
PNG
(US10189816, Compound 67)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4ccc(F)c(c4)C(F)(F)F)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C37H45F4N3O3/c1-22-30(32(44-16-13-36(6,7)14-17-44)31(23(2)42-22)33(34(45)46)47-35(3,4)5)26-9-10-27-21-43(15-12-25(27)19-26)20-24-8-11-29(38)28(18-24)37(39,40)41/h8-11,18-19,33H,12-17,20-21H2,1-7H3,(H,45,46)/t33-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324087
PNG
(US10189816, Compound 80)
Show SMILES Cc1cccc(CN2CCc3cc(ccc3C2)-c2c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c2N2CCC(C)(C)CC2)c1C
Show InChI InChI=1S/C38H51N3O3/c1-24-11-10-12-30(25(24)2)22-40-18-15-28-21-29(13-14-31(28)23-40)32-26(3)39-27(4)33(35(36(42)43)44-37(5,6)7)34(32)41-19-16-38(8,9)17-20-41/h10-14,21,35H,15-20,22-23H2,1-9H3,(H,42,43)/t35-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324088
PNG
(US10189816, Compound 81)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4cccc(c4)C(C)(C)C)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C40H55N3O3/c1-26-33(30-14-15-31-25-42(19-16-29(31)23-30)24-28-12-11-13-32(22-28)38(3,4)5)35(43-20-17-40(9,10)18-21-43)34(27(2)41-26)36(37(44)45)46-39(6,7)8/h11-15,22-23,36H,16-21,24-25H2,1-10H3,(H,44,45)/t36-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324098
PNG
(US10189816, Compound 91)
Show SMILES COc1ccc(CN2CCc3cc(ccc3C2)-c2c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c2N2CCC(C)(C)CC2)c(Cl)c1Cl
Show InChI InChI=1S/C37H47Cl2N3O4/c1-22-29(25-9-10-26-20-41(16-13-24(26)19-25)21-27-11-12-28(45-8)32(39)31(27)38)33(42-17-14-37(6,7)15-18-42)30(23(2)40-22)34(35(43)44)46-36(3,4)5/h9-12,19,34H,13-18,20-21H2,1-8H3,(H,43,44)/t34-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324101
PNG
(US10189816, Compound 94)
Show SMILES COc1cc(CN2CCc3cc(ccc3C2)-c2c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c2N2CCC(C)(C)CC2)c(F)cc1F
Show InChI InChI=1S/C37H47F2N3O4/c1-22-31(25-9-10-26-20-41(14-11-24(26)17-25)21-27-18-30(45-8)29(39)19-28(27)38)33(42-15-12-37(6,7)13-16-42)32(23(2)40-22)34(35(43)44)46-36(3,4)5/h9-10,17-19,34H,11-16,20-21H2,1-8H3,(H,43,44)/t34-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324103
PNG
(US10189816, Compound 96)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4cc(F)cc(F)c4F)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C36H44F3N3O3/c1-21-29(24-8-9-25-19-41(13-10-23(25)16-24)20-26-17-27(37)18-28(38)31(26)39)32(42-14-11-36(6,7)12-15-42)30(22(2)40-21)33(34(43)44)45-35(3,4)5/h8-9,16-18,33H,10-15,19-20H2,1-7H3,(H,43,44)/t33-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324104
PNG
(US10189816, Compound 97)
Show SMILES COc1ccc(CN2CCc3cc(ccc3C2)-c2c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c2N2CCC(C)(C)CC2)cc1F
Show InChI InChI=1S/C37H48FN3O4/c1-23-31(27-10-11-28-22-40(16-13-26(28)20-27)21-25-9-12-30(44-8)29(38)19-25)33(41-17-14-37(6,7)15-18-41)32(24(2)39-23)34(35(42)43)45-36(3,4)5/h9-12,19-20,34H,13-18,21-22H2,1-8H3,(H,42,43)/t34-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324118
PNG
(US10189816, Compound 111)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4cc(F)cc(OC(F)(F)F)c4)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C37H45F4N3O4/c1-22-30(32(44-14-11-36(6,7)12-15-44)31(23(2)42-22)33(34(45)46)48-35(3,4)5)26-8-9-27-21-43(13-10-25(27)18-26)20-24-16-28(38)19-29(17-24)47-37(39,40)41/h8-9,16-19,33H,10-15,20-21H2,1-7H3,(H,45,46)/t33-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324132
PNG
(US10189816, Compound 125)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4ccc(OC(F)(F)C(F)F)cc4)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C38H47F4N3O4/c1-23-30(32(45-18-15-37(6,7)16-19-45)31(24(2)43-23)33(34(46)47)49-36(3,4)5)27-10-11-28-22-44(17-14-26(28)20-27)21-25-8-12-29(13-9-25)48-38(41,42)35(39)40/h8-13,20,33,35H,14-19,21-22H2,1-7H3,(H,46,47)/t33-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324149
PNG
(US10189816, Compound 142)
Show SMILES COc1c(F)cccc1CN1CCc2cc(ccc2C1)-c1c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c1N1CCC(C)(C)CC1
Show InChI InChI=1S/C37H48FN3O4/c1-23-30(26-12-13-27-21-40(17-14-25(27)20-26)22-28-10-9-11-29(38)33(28)44-8)32(41-18-15-37(6,7)16-19-41)31(24(2)39-23)34(35(42)43)45-36(3,4)5/h9-13,20,34H,14-19,21-22H2,1-8H3,(H,42,43)/t34-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324153
PNG
(US10189816, Compound 146)
Show SMILES COc1ccc(CN2CCc3cc(ccc3C2)-c2c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c2N2CCC(C)(C)CC2)c(F)c1
Show InChI InChI=1S/C37H48FN3O4/c1-23-31(26-9-10-27-21-40(16-13-25(27)19-26)22-28-11-12-29(44-8)20-30(28)38)33(41-17-14-37(6,7)15-18-41)32(24(2)39-23)34(35(42)43)45-36(3,4)5/h9-12,19-20,34H,13-18,21-22H2,1-8H3,(H,42,43)/t34-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324169
PNG
(US10189816, Compound 162)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4ccc(cc4)C4(CC4)C#N)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C40H50N4O3/c1-26-33(35(44-20-17-39(6,7)18-21-44)34(27(2)42-26)36(37(45)46)47-38(3,4)5)30-10-11-31-24-43(19-14-29(31)22-30)23-28-8-12-32(13-9-28)40(25-41)15-16-40/h8-13,22,36H,14-21,23-24H2,1-7H3,(H,45,46)/t36-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324170
PNG
(US10189816, Compound 163)
Show SMILES CCCCCCCCCOc1ccc(CN2CCc3cc(ccc3C2)-c2c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c2N2CCC(C)(C)CC2)cc1
Show InChI InChI=1S/C45H65N3O4/c1-9-10-11-12-13-14-15-28-51-38-20-16-34(17-21-38)30-47-25-22-35-29-36(18-19-37(35)31-47)39-32(2)46-33(3)40(42(43(49)50)52-44(4,5)6)41(39)48-26-23-45(7,8)24-27-48/h16-21,29,42H,9-15,22-28,30-31H2,1-8H3,(H,49,50)/t42-/m0/s1
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n/an/an/an/a 76n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324173
PNG
(US10189816, Compound 166)
Show SMILES Cc1cccc(Cl)c1CN1CCc2cc(ccc2C1)-c1c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c1N1CCCC(C)(C)C1
Show InChI InChI=1S/C37H48ClN3O3/c1-23-11-9-12-30(38)29(23)21-40-18-15-26-19-27(13-14-28(26)20-40)31-24(2)39-25(3)32(34(35(42)43)44-36(4,5)6)33(31)41-17-10-16-37(7,8)22-41/h9,11-14,19,34H,10,15-18,20-22H2,1-8H3,(H,42,43)/t34-/m0/s1
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n/an/an/an/a 23n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324017
PNG
(US10189816, Compound 10)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4cccc(c4)C(O)=O)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C37H47N3O5/c1-23-30(27-11-12-29-22-39(16-13-26(29)20-27)21-25-9-8-10-28(19-25)34(41)42)32(40-17-14-37(6,7)15-18-40)31(24(2)38-23)33(35(43)44)45-36(3,4)5/h8-12,19-20,33H,13-18,21-22H2,1-7H3,(H,41,42)(H,43,44)/t33-/m0/s1
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n/an/an/an/a>1.00E+3n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324026
PNG
(US10189816, Compound 19)
Show SMILES Cc1ccc(CN2CCc3cc(ccc3C2)-c2c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c2N2CCC(C)(C)CC2)c(C)c1
Show InChI InChI=1S/C38H51N3O3/c1-24-10-11-30(25(2)20-24)22-40-17-14-28-21-29(12-13-31(28)23-40)32-26(3)39-27(4)33(35(36(42)43)44-37(5,6)7)34(32)41-18-15-38(8,9)16-19-41/h10-13,20-21,35H,14-19,22-23H2,1-9H3,(H,42,43)/t35-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324037
PNG
(US10189816, Compound 30)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4c(F)cccc4C(F)(F)F)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C37H45F4N3O3/c1-22-30(32(44-17-14-36(6,7)15-18-44)31(23(2)42-22)33(34(45)46)47-35(3,4)5)25-11-12-26-20-43(16-13-24(26)19-25)21-27-28(37(39,40)41)9-8-10-29(27)38/h8-12,19,33H,13-18,20-21H2,1-7H3,(H,45,46)/t33-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324048
PNG
(US10189816, Compound 41)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4ccc(F)c(F)c4F)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C36H44F3N3O3/c1-21-28(24-8-9-25-19-41(15-12-23(25)18-24)20-26-10-11-27(37)31(39)30(26)38)32(42-16-13-36(6,7)14-17-42)29(22(2)40-21)33(34(43)44)45-35(3,4)5/h8-11,18,33H,12-17,19-20H2,1-7H3,(H,43,44)/t33-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324049
PNG
(US10189816, Compound 42)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4cc(Cl)ccc4F)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C36H45ClFN3O3/c1-22-30(25-8-9-26-20-40(15-12-24(26)18-25)21-27-19-28(37)10-11-29(27)38)32(41-16-13-36(6,7)14-17-41)31(23(2)39-22)33(34(42)43)44-35(3,4)5/h8-11,18-19,33H,12-17,20-21H2,1-7H3,(H,42,43)/t33-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324054
PNG
(US10189816, Compound 47)
Show SMILES Cc1ccc(F)cc1CN1CCc2cc(ccc2C1)-c1c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c1N1CCC(C)(C)CC1
Show InChI InChI=1S/C37H48FN3O3/c1-23-9-12-30(38)20-29(23)22-40-16-13-26-19-27(10-11-28(26)21-40)31-24(2)39-25(3)32(34(35(42)43)44-36(4,5)6)33(31)41-17-14-37(7,8)15-18-41/h9-12,19-20,34H,13-18,21-22H2,1-8H3,(H,42,43)/t34-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324061
PNG
(US10189816, Compound 54)
Show SMILES Cc1cccc(CN2CCc3cc(ccc3C2)-c2c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c2N2CCC(C)(C)CC2)c1F
Show InChI InChI=1S/C37H48FN3O3/c1-23-10-9-11-29(32(23)38)22-40-17-14-26-20-27(12-13-28(26)21-40)30-24(2)39-25(3)31(34(35(42)43)44-36(4,5)6)33(30)41-18-15-37(7,8)16-19-41/h9-13,20,34H,14-19,21-22H2,1-8H3,(H,42,43)/t34-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324066
PNG
(US10189816, Compound 59)
Show SMILES CC(C)c1ccc(CN2CCc3cc(ccc3C2)-c2c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c2N2CCC(C)(C)CC2)cc1
Show InChI InChI=1S/C39H53N3O3/c1-25(2)29-12-10-28(11-13-29)23-41-19-16-30-22-31(14-15-32(30)24-41)33-26(3)40-27(4)34(36(37(43)44)45-38(5,6)7)35(33)42-20-17-39(8,9)18-21-42/h10-15,22,25,36H,16-21,23-24H2,1-9H3,(H,43,44)/t36-/m0/s1
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n/an/an/an/a 58n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324067
PNG
(US10189816, Compound 60)
Show SMILES CCc1ccc(CN2CCc3cc(ccc3C2)-c2c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c2N2CCC(C)(C)CC2)cc1
Show InChI InChI=1S/C38H51N3O3/c1-9-27-10-12-28(13-11-27)23-40-19-16-29-22-30(14-15-31(29)24-40)32-25(2)39-26(3)33(35(36(42)43)44-37(4,5)6)34(32)41-20-17-38(7,8)18-21-41/h10-15,22,35H,9,16-21,23-24H2,1-8H3,(H,42,43)/t35-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324071
PNG
(US10189816, Compound 64)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4ccc(cc4)C#N)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C37H46N4O3/c1-24-31(29-12-13-30-23-40(17-14-28(30)20-29)22-27-10-8-26(21-38)9-11-27)33(41-18-15-37(6,7)16-19-41)32(25(2)39-24)34(35(42)43)44-36(3,4)5/h8-13,20,34H,14-19,22-23H2,1-7H3,(H,42,43)/t34-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324075
PNG
(US10189816, Compound 68)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4cc(F)cc(c4)C(F)(F)F)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C37H45F4N3O3/c1-22-30(32(44-14-11-36(6,7)12-15-44)31(23(2)42-22)33(34(45)46)47-35(3,4)5)26-8-9-27-21-43(13-10-25(27)18-26)20-24-16-28(37(39,40)41)19-29(38)17-24/h8-9,16-19,33H,10-15,20-21H2,1-7H3,(H,45,46)/t33-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324080
PNG
(US10189816, Compound 73)
Show SMILES Cc1ccc(CN2CCc3cc(ccc3C2)-c2c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c2N2CCC(C)(C)CC2)c(F)c1F
Show InChI InChI=1S/C37H47F2N3O3/c1-22-9-10-28(32(39)31(22)38)21-41-16-13-25-19-26(11-12-27(25)20-41)29-23(2)40-24(3)30(34(35(43)44)45-36(4,5)6)33(29)42-17-14-37(7,8)15-18-42/h9-12,19,34H,13-18,20-21H2,1-8H3,(H,43,44)/t34-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324083
PNG
(US10189816, Compound 76)
Show SMILES Cc1cc(CN2CCc3cc(ccc3C2)-c2c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c2N2CCC(C)(C)CC2)cc(F)c1F
Show InChI InChI=1S/C37H47F2N3O3/c1-22-17-25(18-29(38)32(22)39)20-41-14-11-26-19-27(9-10-28(26)21-41)30-23(2)40-24(3)31(34(35(43)44)45-36(4,5)6)33(30)42-15-12-37(7,8)13-16-42/h9-10,17-19,34H,11-16,20-21H2,1-8H3,(H,43,44)/t34-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324087
PNG
(US10189816, Compound 80)
Show SMILES Cc1cccc(CN2CCc3cc(ccc3C2)-c2c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c2N2CCC(C)(C)CC2)c1C
Show InChI InChI=1S/C38H51N3O3/c1-24-11-10-12-30(25(24)2)22-40-18-15-28-21-29(13-14-31(28)23-40)32-26(3)39-27(4)33(35(36(42)43)44-37(5,6)7)34(32)41-19-16-38(8,9)17-20-41/h10-14,21,35H,15-20,22-23H2,1-9H3,(H,42,43)/t35-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324090
PNG
(US10189816, Compound 83)
Show SMILES COc1cc(F)c(CN2CCc3cc(ccc3C2)-c2c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c2N2CCC(C)(C)CC2)cc1F
Show InChI InChI=1S/C37H47F2N3O4/c1-22-31(25-9-10-26-20-41(14-11-24(26)17-25)21-27-18-29(39)30(45-8)19-28(27)38)33(42-15-12-37(6,7)13-16-42)32(23(2)40-22)34(35(43)44)46-36(3,4)5/h9-10,17-19,34H,11-16,20-21H2,1-8H3,(H,43,44)/t34-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324096
PNG
(US10189816, Compound 107 | US10189816, Compound 89)
Show SMILES COc1cc(F)cc(F)c1CN1CCc2cc(ccc2C1)-c1c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c1N1CCC(C)(C)CC1
Show InChI InChI=1S/C37H47F2N3O4/c1-22-31(25-9-10-26-20-41(14-11-24(26)17-25)21-28-29(39)18-27(38)19-30(28)45-8)33(42-15-12-37(6,7)13-16-42)32(23(2)40-22)34(35(43)44)46-36(3,4)5/h9-10,17-19,34H,11-16,20-21H2,1-8H3,(H,43,44)/t34-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324100
PNG
(US10189816, Compound 93)
Show SMILES COc1cc(CN2CCc3cc(ccc3C2)-c2c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c2N2CCC(C)(C)CC2)c(F)cc1Cl
Show InChI InChI=1S/C37H47ClFN3O4/c1-22-31(25-9-10-26-20-41(14-11-24(26)17-25)21-27-18-30(45-8)28(38)19-29(27)39)33(42-15-12-37(6,7)13-16-42)32(23(2)40-22)34(35(43)44)46-36(3,4)5/h9-10,17-19,34H,11-16,20-21H2,1-8H3,(H,43,44)/t34-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324103
PNG
(US10189816, Compound 96)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4cc(F)cc(F)c4F)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C36H44F3N3O3/c1-21-29(24-8-9-25-19-41(13-10-23(25)16-24)20-26-17-27(37)18-28(38)31(26)39)32(42-14-11-36(6,7)12-15-42)30(22(2)40-21)33(34(43)44)45-35(3,4)5/h8-9,16-18,33H,10-15,19-20H2,1-7H3,(H,43,44)/t33-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324108
PNG
(US10189816, Compound 101)
Show SMILES COc1cc(CN2CCc3cc(ccc3C2)-c2c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c2N2CCC(C)(C)CC2)ccc1F
Show InChI InChI=1S/C37H48FN3O4/c1-23-31(27-10-11-28-22-40(16-13-26(28)20-27)21-25-9-12-29(38)30(19-25)44-8)33(41-17-14-37(6,7)15-18-41)32(24(2)39-23)34(35(42)43)45-36(3,4)5/h9-12,19-20,34H,13-18,21-22H2,1-8H3,(H,42,43)/t34-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324112
PNG
(US10189816, Compound 105)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4ccc(OC(F)F)cc4F)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C37H46F3N3O4/c1-22-30(32(43-16-13-37(6,7)14-17-43)31(23(2)41-22)33(34(44)45)47-36(3,4)5)25-8-9-26-20-42(15-12-24(26)18-25)21-27-10-11-28(19-29(27)38)46-35(39)40/h8-11,18-19,33,35H,12-17,20-21H2,1-7H3,(H,44,45)/t33-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324123
PNG
(US10189816, Compound 116)
Show SMILES COc1ccc(F)c(CN2CCc3cc(ccc3C2)-c2c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c2N2CCC(C)(C)CC2)c1
Show InChI InChI=1S/C37H48FN3O4/c1-23-31(26-9-10-27-21-40(16-13-25(27)19-26)22-28-20-29(44-8)11-12-30(28)38)33(41-17-14-37(6,7)15-18-41)32(24(2)39-23)34(35(42)43)45-36(3,4)5/h9-12,19-20,34H,13-18,21-22H2,1-8H3,(H,42,43)/t34-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324127
PNG
(US10189816, Compound 120)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4ccc(F)c(OC(F)(F)F)c4)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C37H45F4N3O4/c1-22-30(32(44-16-13-36(6,7)14-17-44)31(23(2)42-22)33(34(45)46)48-35(3,4)5)26-9-10-27-21-43(15-12-25(27)19-26)20-24-8-11-28(38)29(18-24)47-37(39,40)41/h8-11,18-19,33H,12-17,20-21H2,1-7H3,(H,45,46)/t33-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324143
PNG
(US10189816, Compound 136)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4c(F)cccc4Cl)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C36H45ClFN3O3/c1-22-30(25-11-12-26-20-40(16-13-24(26)19-25)21-27-28(37)9-8-10-29(27)38)32(41-17-14-36(6,7)15-18-41)31(23(2)39-22)33(34(42)43)44-35(3,4)5/h8-12,19,33H,13-18,20-21H2,1-7H3,(H,42,43)/t33-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324148
PNG
(US10189816, Compound 141)
Show SMILES COc1ccc(CN2CCc3cc(ccc3C2)-c2c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c2N2CCC(C)(C)CC2)cc1C
Show InChI InChI=1S/C38H51N3O4/c1-24-20-27(10-13-31(24)44-9)22-40-17-14-28-21-29(11-12-30(28)23-40)32-25(2)39-26(3)33(35(36(42)43)45-37(4,5)6)34(32)41-18-15-38(7,8)16-19-41/h10-13,20-21,35H,14-19,22-23H2,1-9H3,(H,42,43)/t35-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324154
PNG
(US10189816, Compound 147)
Show SMILES COc1ccc(CN2CCc3cc(ccc3C2)-c2c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c2N2CCC(C)(C)CC2)c(C)c1C
Show InChI InChI=1S/C39H53N3O4/c1-24-25(2)32(45-10)14-13-30(24)22-41-18-15-28-21-29(11-12-31(28)23-41)33-26(3)40-27(4)34(36(37(43)44)46-38(5,6)7)35(33)42-19-16-39(8,9)17-20-42/h11-14,21,36H,15-20,22-23H2,1-10H3,(H,43,44)/t36-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324161
PNG
(US10189816, Compound 154)
Show SMILES CC(C)Oc1cccc(CN2CCc3cc(ccc3C2)-c2c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c2N2CCC(C)(C)CC2)c1
Show InChI InChI=1S/C39H53N3O4/c1-25(2)45-32-12-10-11-28(21-32)23-41-18-15-29-22-30(13-14-31(29)24-41)33-26(3)40-27(4)34(36(37(43)44)46-38(5,6)7)35(33)42-19-16-39(8,9)17-20-42/h10-14,21-22,25,36H,15-20,23-24H2,1-9H3,(H,43,44)/t36-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324163
PNG
(US10189816, Compound 156)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4ccc5OCCOc5c4)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C38H49N3O5/c1-24-32(34(41-16-13-38(6,7)14-17-41)33(25(2)39-24)35(36(42)43)46-37(3,4)5)28-9-10-29-23-40(15-12-27(29)21-28)22-26-8-11-30-31(20-26)45-19-18-44-30/h8-11,20-21,35H,12-19,22-23H2,1-7H3,(H,42,43)/t35-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324164
PNG
(US10189816, Compound 157)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4ccc(OC(F)F)c(OC(F)F)c4)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C38H47F4N3O5/c1-22-30(32(45-16-13-38(6,7)14-17-45)31(23(2)43-22)33(34(46)47)50-37(3,4)5)26-9-10-27-21-44(15-12-25(27)19-26)20-24-8-11-28(48-35(39)40)29(18-24)49-36(41)42/h8-11,18-19,33,35-36H,12-17,20-21H2,1-7H3,(H,46,47)/t33-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324165
PNG
(US10189816, Compound 158)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4cccc5OCCOc45)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C38H49N3O5/c1-24-31(33(41-17-14-38(6,7)15-18-41)32(25(2)39-24)35(36(42)43)46-37(3,4)5)27-11-12-28-22-40(16-13-26(28)21-27)23-29-9-8-10-30-34(29)45-20-19-44-30/h8-12,21,35H,13-20,22-23H2,1-7H3,(H,42,43)/t35-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM323830
PNG
(US10189816, Compound 1)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4ccc(F)cc4)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C36H46FN3O3/c1-23-30(27-10-11-28-22-39(17-14-26(28)20-27)21-25-8-12-29(37)13-9-25)32(40-18-15-36(6,7)16-19-40)31(24(2)38-23)33(34(41)42)43-35(3,4)5/h8-13,20,33H,14-19,21-22H2,1-7H3,(H,41,42)/t33-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324022
PNG
(US10189816, Compound 15)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4cccc(c4C)C(F)(F)F)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C38H48F3N3O3/c1-23-28(10-9-11-30(23)38(39,40)41)21-43-17-14-26-20-27(12-13-29(26)22-43)31-24(2)42-25(3)32(34(35(45)46)47-36(4,5)6)33(31)44-18-15-37(7,8)16-19-44/h9-13,20,34H,14-19,21-22H2,1-8H3,(H,45,46)/t34-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324035
PNG
(US10189816, Compound 28)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4cccc(Cl)c4)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C36H46ClN3O3/c1-23-30(27-11-12-28-22-39(16-13-26(28)20-27)21-25-9-8-10-29(37)19-25)32(40-17-14-36(6,7)15-18-40)31(24(2)38-23)33(34(41)42)43-35(3,4)5/h8-12,19-20,33H,13-18,21-22H2,1-7H3,(H,41,42)/t33-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324052
PNG
(US10189816, Compound 45)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4cc(F)ccc4Cl)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C36H45ClFN3O3/c1-22-30(25-8-9-26-20-40(15-12-24(26)18-25)21-27-19-28(38)10-11-29(27)37)32(41-16-13-36(6,7)14-17-41)31(23(2)39-22)33(34(42)43)44-35(3,4)5/h8-11,18-19,33H,12-17,20-21H2,1-7H3,(H,42,43)/t33-/m0/s1
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n/an/an/an/a 3n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324058
PNG
(US10189816, Compound 51)
Show SMILES Cc1cccc(F)c1CN1CCc2cc(ccc2C1)-c1c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c1N1CCC(C)(C)CC1
Show InChI InChI=1S/C37H48FN3O3/c1-23-10-9-11-30(38)29(23)22-40-17-14-26-20-27(12-13-28(26)21-40)31-24(2)39-25(3)32(34(35(42)43)44-36(4,5)6)33(31)41-18-15-37(7,8)16-19-41/h9-13,20,34H,14-19,21-22H2,1-8H3,(H,42,43)/t34-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324063
PNG
(US10189816, Compound 56)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4ccc(Cl)cc4)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C36H46ClN3O3/c1-23-30(27-10-11-28-22-39(17-14-26(28)20-27)21-25-8-12-29(37)13-9-25)32(40-18-15-36(6,7)16-19-40)31(24(2)38-23)33(34(41)42)43-35(3,4)5/h8-13,20,33H,14-19,21-22H2,1-7H3,(H,41,42)/t33-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324065
PNG
(US10189816, Compound 58)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4c(F)cc(F)cc4F)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C36H44F3N3O3/c1-21-30(24-8-9-25-19-41(13-10-23(25)16-24)20-27-28(38)17-26(37)18-29(27)39)32(42-14-11-36(6,7)12-15-42)31(22(2)40-21)33(34(43)44)45-35(3,4)5/h8-9,16-18,33H,10-15,19-20H2,1-7H3,(H,43,44)/t33-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324078
PNG
(US10189816, Compound 71)
Show SMILES Cc1cc(CN2CCc3cc(ccc3C2)-c2c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c2N2CCC(C)(C)CC2)ccc1F
Show InChI InChI=1S/C37H48FN3O3/c1-23-19-26(9-12-30(23)38)21-40-16-13-27-20-28(10-11-29(27)22-40)31-24(2)39-25(3)32(34(35(42)43)44-36(4,5)6)33(31)41-17-14-37(7,8)15-18-41/h9-12,19-20,34H,13-18,21-22H2,1-8H3,(H,42,43)/t34-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324084
PNG
(US10189816, Compound 77)
Show SMILES CC(C)c1ccccc1CN1CCc2cc(ccc2C1)-c1c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c1N1CCC(C)(C)CC1
Show InChI InChI=1S/C39H53N3O3/c1-25(2)32-13-11-10-12-31(32)24-41-19-16-28-22-29(14-15-30(28)23-41)33-26(3)40-27(4)34(36(37(43)44)45-38(5,6)7)35(33)42-20-17-39(8,9)18-21-42/h10-15,22,25,36H,16-21,23-24H2,1-9H3,(H,43,44)/t36-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324085
PNG
(US10189816, Compound 78)
Show SMILES Cc1cc(C)c(CN2CCc3cc(ccc3C2)-c2c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c2N2CCC(C)(C)CC2)cc1C
Show InChI InChI=1S/C39H53N3O3/c1-24-19-26(3)32(20-25(24)2)23-41-16-13-29-21-30(11-12-31(29)22-41)33-27(4)40-28(5)34(36(37(43)44)45-38(6,7)8)35(33)42-17-14-39(9,10)15-18-42/h11-12,19-21,36H,13-18,22-23H2,1-10H3,(H,43,44)/t36-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324107
PNG
(US10189816, Compound 100)
Show SMILES COc1cc(Cl)cc(CN2CCc3cc(ccc3C2)-c2c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c2N2CCC(C)(C)CC2)c1
Show InChI InChI=1S/C37H48ClN3O4/c1-23-31(27-9-10-28-22-40(14-11-26(28)19-27)21-25-17-29(38)20-30(18-25)44-8)33(41-15-12-37(6,7)13-16-41)32(24(2)39-23)34(35(42)43)45-36(3,4)5/h9-10,17-20,34H,11-16,21-22H2,1-8H3,(H,42,43)/t34-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324109
PNG
(US10189816, Compound 102)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4ccc(OC(F)(F)F)cc4)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C37H46F3N3O4/c1-23-30(32(43-18-15-36(6,7)16-19-43)31(24(2)41-23)33(34(44)45)47-35(3,4)5)27-10-11-28-22-42(17-14-26(28)20-27)21-25-8-12-29(13-9-25)46-37(38,39)40/h8-13,20,33H,14-19,21-22H2,1-7H3,(H,44,45)/t33-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324116
PNG
(US10189816, Compound 109)
Show SMILES COc1cc(ccc1CN1CCc2cc(ccc2C1)-c1c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c1N1CCC(C)(C)CC1)C(F)(F)F
Show InChI InChI=1S/C38H48F3N3O4/c1-23-31(33(44-17-14-37(6,7)15-18-44)32(24(2)42-23)34(35(45)46)48-36(3,4)5)26-9-10-27-21-43(16-13-25(27)19-26)22-28-11-12-29(38(39,40)41)20-30(28)47-8/h9-12,19-20,34H,13-18,21-22H2,1-8H3,(H,45,46)/t34-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324138
PNG
(US10189816, Compound 131)
Show SMILES Cc1cc(Cl)ccc1CN1CCc2cc(ccc2C1)-c1c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c1N1CCC(C)(C)CC1
Show InChI InChI=1S/C37H48ClN3O3/c1-23-19-30(38)12-11-28(23)21-40-16-13-26-20-27(9-10-29(26)22-40)31-24(2)39-25(3)32(34(35(42)43)44-36(4,5)6)33(31)41-17-14-37(7,8)15-18-41/h9-12,19-20,34H,13-18,21-22H2,1-8H3,(H,42,43)/t34-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324142
PNG
(US10189816, Compound 135)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4c(F)cc(Cl)cc4F)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C36H44ClF2N3O3/c1-21-30(24-8-9-25-19-41(13-10-23(25)16-24)20-27-28(38)17-26(37)18-29(27)39)32(42-14-11-36(6,7)12-15-42)31(22(2)40-21)33(34(43)44)45-35(3,4)5/h8-9,16-18,33H,10-15,19-20H2,1-7H3,(H,43,44)/t33-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324146
PNG
(US10189816, Compound 139)
Show SMILES COc1ccc(cc1CN1CCc2cc(ccc2C1)-c1c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c1N1CCC(C)(C)CC1)C(C)C
Show InChI InChI=1S/C40H55N3O4/c1-25(2)28-13-14-33(46-10)32(21-28)24-42-18-15-29-22-30(11-12-31(29)23-42)34-26(3)41-27(4)35(37(38(44)45)47-39(5,6)7)36(34)43-19-16-40(8,9)17-20-43/h11-14,21-22,25,37H,15-20,23-24H2,1-10H3,(H,44,45)/t37-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324147
PNG
(US10189816, Compound 140)
Show SMILES COc1cc(CN2CCc3cc(ccc3C2)-c2c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c2N2CCC(C)(C)CC2)ccc1C
Show InChI InChI=1S/C38H51N3O4/c1-24-10-11-27(20-31(24)44-9)22-40-17-14-28-21-29(12-13-30(28)23-40)32-25(2)39-26(3)33(35(36(42)43)45-37(4,5)6)34(32)41-18-15-38(7,8)16-19-41/h10-13,20-21,35H,14-19,22-23H2,1-9H3,(H,42,43)/t35-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324152
PNG
(US10189816, Compound 145)
Show SMILES COc1cccc(Cl)c1CN1CCc2cc(ccc2C1)-c1c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c1N1CCC(C)(C)CC1
Show InChI InChI=1S/C37H48ClN3O4/c1-23-31(26-12-13-27-21-40(17-14-25(27)20-26)22-28-29(38)10-9-11-30(28)44-8)33(41-18-15-37(6,7)16-19-41)32(24(2)39-23)34(35(42)43)45-36(3,4)5/h9-13,20,34H,14-19,21-22H2,1-8H3,(H,42,43)/t34-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324158
PNG
(US10189816, Compound 151)
Show SMILES COc1ccc(cc1CN1CCc2cc(ccc2C1)-c1c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c1N1CCC(C)(C)CC1)C(F)(F)F
Show InChI InChI=1S/C38H48F3N3O4/c1-23-31(33(44-17-14-37(6,7)15-18-44)32(24(2)42-23)34(35(45)46)48-36(3,4)5)26-9-10-27-21-43(16-13-25(27)19-26)22-28-20-29(38(39,40)41)11-12-30(28)47-8/h9-12,19-20,34H,13-18,21-22H2,1-8H3,(H,45,46)/t34-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324171
PNG
(US10189816, Compound 164)
Show SMILES Cc1cccc(Cl)c1CN1CCc2cc(ccc2C1)-c1cnc(C)c([C@H](OC(C)(C)C)C(O)=O)c1N1CCC(C)(C)CC1
Show InChI InChI=1S/C36H46ClN3O3/c1-23-9-8-10-30(37)29(23)22-39-16-13-25-19-26(11-12-27(25)21-39)28-20-38-24(2)31(33(34(41)42)43-35(3,4)5)32(28)40-17-14-36(6,7)15-18-40/h8-12,19-20,33H,13-18,21-22H2,1-7H3,(H,41,42)/t33-/m0/s1
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n/an/an/an/a 3n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324017
PNG
(US10189816, Compound 10)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4cccc(c4)C(O)=O)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C37H47N3O5/c1-23-30(27-11-12-29-22-39(16-13-26(29)20-27)21-25-9-8-10-28(19-25)34(41)42)32(40-17-14-37(6,7)15-18-40)31(24(2)38-23)33(35(43)44)45-36(3,4)5/h8-12,19-20,33H,13-18,21-22H2,1-7H3,(H,41,42)(H,43,44)/t33-/m0/s1
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n/an/an/an/a 1.48E+3n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324027
PNG
(US10189816, Compound 20)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4ccc(F)cc4F)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C36H45F2N3O3/c1-22-30(25-8-9-26-20-40(15-12-24(26)18-25)21-27-10-11-28(37)19-29(27)38)32(41-16-13-36(6,7)14-17-41)31(23(2)39-22)33(34(42)43)44-35(3,4)5/h8-11,18-19,33H,12-17,20-21H2,1-7H3,(H,42,43)/t33-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324030
PNG
(US10189816, Compound 23)
Show SMILES Cc1cccc(Cl)c1CN1CCc2cc(ccc2C1)-c1c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c1N1CCC(C)(C)CC1
Show InChI InChI=1S/C37H48ClN3O3/c1-23-10-9-11-30(38)29(23)22-40-17-14-26-20-27(12-13-28(26)21-40)31-24(2)39-25(3)32(34(35(42)43)44-36(4,5)6)33(31)41-18-15-37(7,8)16-19-41/h9-13,20,34H,14-19,21-22H2,1-8H3,(H,42,43)/t34-/m0/s1
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n/an/an/an/a 3n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324032
PNG
(US10189816, Compound 25)
Show SMILES Cc1cc(F)ccc1CN1CCc2cc(ccc2C1)-c1c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c1N1CCC(C)(C)CC1
Show InChI InChI=1S/C37H48FN3O3/c1-23-19-30(38)12-11-28(23)21-40-16-13-26-20-27(9-10-29(26)22-40)31-24(2)39-25(3)32(34(35(42)43)44-36(4,5)6)33(31)41-17-14-37(7,8)15-18-41/h9-12,19-20,34H,13-18,21-22H2,1-8H3,(H,42,43)/t34-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324036
PNG
(US10189816, Compound 29)
Show SMILES Cc1ccc(C)c(CN2CCc3cc(ccc3C2)-c2c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c2N2CCC(C)(C)CC2)c1
Show InChI InChI=1S/C38H51N3O3/c1-24-10-11-25(2)31(20-24)23-40-17-14-28-21-29(12-13-30(28)22-40)32-26(3)39-27(4)33(35(36(42)43)44-37(5,6)7)34(32)41-18-15-38(8,9)16-19-41/h10-13,20-21,35H,14-19,22-23H2,1-9H3,(H,42,43)/t35-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324038
PNG
(US10189816, Compound 31)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4cc(F)cc(F)c4)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C36H45F2N3O3/c1-22-30(26-8-9-27-21-40(13-10-25(27)18-26)20-24-16-28(37)19-29(38)17-24)32(41-14-11-36(6,7)12-15-41)31(23(2)39-22)33(34(42)43)44-35(3,4)5/h8-9,16-19,33H,10-15,20-21H2,1-7H3,(H,42,43)/t33-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324052
PNG
(US10189816, Compound 45)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4cc(F)ccc4Cl)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C36H45ClFN3O3/c1-22-30(25-8-9-26-20-40(15-12-24(26)18-25)21-27-19-28(38)10-11-29(27)37)32(41-16-13-36(6,7)14-17-41)31(23(2)39-22)33(34(42)43)44-35(3,4)5/h8-11,18-19,33H,12-17,20-21H2,1-7H3,(H,42,43)/t33-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324060
PNG
(US10189816, Compound 53)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4ccc(Cl)cc4Cl)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C36H45Cl2N3O3/c1-22-30(25-8-9-26-20-40(15-12-24(26)18-25)21-27-10-11-28(37)19-29(27)38)32(41-16-13-36(6,7)14-17-41)31(23(2)39-22)33(34(42)43)44-35(3,4)5/h8-11,18-19,33H,12-17,20-21H2,1-7H3,(H,42,43)/t33-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324073
PNG
(US10189816, Compound 66)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4cc(F)ccc4C(F)(F)F)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C37H45F4N3O3/c1-22-30(32(44-16-13-36(6,7)14-17-44)31(23(2)42-22)33(34(45)46)47-35(3,4)5)25-8-9-26-20-43(15-12-24(26)18-25)21-27-19-28(38)10-11-29(27)37(39,40)41/h8-11,18-19,33H,12-17,20-21H2,1-7H3,(H,45,46)/t33-/m0/s1
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n/an/an/an/a 13n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324080
PNG
(US10189816, Compound 73)
Show SMILES Cc1ccc(CN2CCc3cc(ccc3C2)-c2c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c2N2CCC(C)(C)CC2)c(F)c1F
Show InChI InChI=1S/C37H47F2N3O3/c1-22-9-10-28(32(39)31(22)38)21-41-16-13-25-19-26(11-12-27(25)20-41)29-23(2)40-24(3)30(34(35(43)44)45-36(4,5)6)33(29)42-17-14-37(7,8)15-18-42/h9-12,19,34H,13-18,20-21H2,1-8H3,(H,43,44)/t34-/m0/s1
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n/an/an/an/a 7n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324086
PNG
(US10189816, Compound 79)
Show SMILES Cc1cc(C)cc(CN2CCc3cc(ccc3C2)-c2c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c2N2CCC(C)(C)CC2)c1
Show InChI InChI=1S/C38H51N3O3/c1-24-18-25(2)20-28(19-24)22-40-15-12-29-21-30(10-11-31(29)23-40)32-26(3)39-27(4)33(35(36(42)43)44-37(5,6)7)34(32)41-16-13-38(8,9)14-17-41/h10-11,18-21,35H,12-17,22-23H2,1-9H3,(H,42,43)/t35-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324091
PNG
(US10189816, Compound 106 | US10189816, Compound 84)
Show SMILES COc1cc(F)c(CN2CCc3cc(ccc3C2)-c2c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c2N2CCC(C)(C)CC2)c(F)c1
Show InChI InChI=1S/C37H47F2N3O4/c1-22-31(25-9-10-26-20-41(14-11-24(26)17-25)21-28-29(38)18-27(45-8)19-30(28)39)33(42-15-12-37(6,7)13-16-42)32(23(2)40-22)34(35(43)44)46-36(3,4)5/h9-10,17-19,34H,11-16,20-21H2,1-8H3,(H,43,44)/t34-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324094
PNG
(US10189816, Compound 87)
Show SMILES COc1ccc(F)c(F)c1CN1CCc2cc(ccc2C1)-c1c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c1N1CCC(C)(C)CC1
Show InChI InChI=1S/C37H47F2N3O4/c1-22-30(25-9-10-26-20-41(16-13-24(26)19-25)21-27-29(45-8)12-11-28(38)32(27)39)33(42-17-14-37(6,7)15-18-42)31(23(2)40-22)34(35(43)44)46-36(3,4)5/h9-12,19,34H,13-18,20-21H2,1-8H3,(H,43,44)/t34-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324095
PNG
(US10189816, Compound 88)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4ccccc4OCCO)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C38H51N3O5/c1-25-32(28-12-13-29-23-40(17-14-27(29)22-28)24-30-10-8-9-11-31(30)45-21-20-42)34(41-18-15-38(6,7)16-19-41)33(26(2)39-25)35(36(43)44)46-37(3,4)5/h8-13,22,35,42H,14-21,23-24H2,1-7H3,(H,43,44)/t35-/m0/s1
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n/an/an/an/a 12n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324097
PNG
(US10189816, Compound 90)
Show SMILES CCOc1cc(Cl)cc(Cl)c1CN1CCc2cc(ccc2C1)-c1c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c1N1CCC(C)(C)CC1
Show InChI InChI=1S/C38H49Cl2N3O4/c1-9-46-31-20-28(39)19-30(40)29(31)22-42-15-12-25-18-26(10-11-27(25)21-42)32-23(2)41-24(3)33(35(36(44)45)47-37(4,5)6)34(32)43-16-13-38(7,8)14-17-43/h10-11,18-20,35H,9,12-17,21-22H2,1-8H3,(H,44,45)/t35-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324110
PNG
(US10189816, Compound 103)
Show SMILES CCOc1cccc(CN2CCc3cc(ccc3C2)-c2c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c2N2CCC(C)(C)CC2)c1
Show InChI InChI=1S/C38H51N3O4/c1-9-44-31-12-10-11-27(21-31)23-40-18-15-28-22-29(13-14-30(28)24-40)32-25(2)39-26(3)33(35(36(42)43)45-37(4,5)6)34(32)41-19-16-38(7,8)17-20-41/h10-14,21-22,35H,9,15-20,23-24H2,1-8H3,(H,42,43)/t35-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324111
PNG
(US10189816, Compound 104)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4ccc(OC(F)(F)F)c(Cl)c4)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C37H45ClF3N3O4/c1-22-30(32(44-16-13-36(6,7)14-17-44)31(23(2)42-22)33(34(45)46)48-35(3,4)5)26-9-10-27-21-43(15-12-25(27)19-26)20-24-8-11-29(28(38)18-24)47-37(39,40)41/h8-11,18-19,33H,12-17,20-21H2,1-7H3,(H,45,46)/t33-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324128
PNG
(US10189816, Compound 121)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4cccc(OC(F)(F)C(F)F)c4)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C38H47F4N3O4/c1-23-30(32(45-17-14-37(6,7)15-18-45)31(24(2)43-23)33(34(46)47)49-36(3,4)5)27-11-12-28-22-44(16-13-26(28)20-27)21-25-9-8-10-29(19-25)48-38(41,42)35(39)40/h8-12,19-20,33,35H,13-18,21-22H2,1-7H3,(H,46,47)/t33-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324139
PNG
(US10189816, Compound 132)
Show SMILES Cc1ccc(CN2CCc3cc(ccc3C2)-c2c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c2N2CCC(C)(C)CC2)cc1Cl
Show InChI InChI=1S/C37H48ClN3O3/c1-23-9-10-26(19-30(23)38)21-40-16-13-27-20-28(11-12-29(27)22-40)31-24(2)39-25(3)32(34(35(42)43)44-36(4,5)6)33(31)41-17-14-37(7,8)15-18-41/h9-12,19-20,34H,13-18,21-22H2,1-8H3,(H,42,43)/t34-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324140
PNG
(US10189816, Compound 133)
Show SMILES Cc1ccc(Cl)cc1CN1CCc2cc(ccc2C1)-c1c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c1N1CCC(C)(C)CC1
Show InChI InChI=1S/C37H48ClN3O3/c1-23-9-12-30(38)20-29(23)22-40-16-13-26-19-27(10-11-28(26)21-40)31-24(2)39-25(3)32(34(35(42)43)44-36(4,5)6)33(31)41-17-14-37(7,8)15-18-41/h9-12,19-20,34H,13-18,21-22H2,1-8H3,(H,42,43)/t34-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324141
PNG
(US10189816, Compound 134)
Show SMILES Cc1cc(CN2CCc3cc(ccc3C2)-c2c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c2N2CCC(C)(C)CC2)ccc1Cl
Show InChI InChI=1S/C37H48ClN3O3/c1-23-19-26(9-12-30(23)38)21-40-16-13-27-20-28(10-11-29(27)22-40)31-24(2)39-25(3)32(34(35(42)43)44-36(4,5)6)33(31)41-17-14-37(7,8)15-18-41/h9-12,19-20,34H,13-18,21-22H2,1-8H3,(H,42,43)/t34-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324150
PNG
(US10189816, Compound 143)
Show SMILES COc1ccc(CN2CCc3cc(ccc3C2)-c2c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c2N2CCC(C)(C)CC2)cc1C(C)C
Show InChI InChI=1S/C40H55N3O4/c1-25(2)32-21-28(11-14-33(32)46-10)23-42-18-15-29-22-30(12-13-31(29)24-42)34-26(3)41-27(4)35(37(38(44)45)47-39(5,6)7)36(34)43-19-16-40(8,9)17-20-43/h11-14,21-22,25,37H,15-20,23-24H2,1-10H3,(H,44,45)/t37-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324155
PNG
(US10189816, Compound 148)
Show SMILES COc1cc(C)c(CN2CCc3cc(ccc3C2)-c2c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c2N2CCC(C)(C)CC2)cc1C
Show InChI InChI=1S/C39H53N3O4/c1-24-20-32(45-10)25(2)19-31(24)23-41-16-13-28-21-29(11-12-30(28)22-41)33-26(3)40-27(4)34(36(37(43)44)46-38(5,6)7)35(33)42-17-14-39(8,9)15-18-42/h11-12,19-21,36H,13-18,22-23H2,1-10H3,(H,43,44)/t36-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324159
PNG
(US10189816, Compound 152)
Show SMILES CC(C)Oc1ccccc1CN1CCc2cc(ccc2C1)-c1c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c1N1CCC(C)(C)CC1
Show InChI InChI=1S/C39H53N3O4/c1-25(2)45-32-13-11-10-12-31(32)24-41-19-16-28-22-29(14-15-30(28)23-41)33-26(3)40-27(4)34(36(37(43)44)46-38(5,6)7)35(33)42-20-17-39(8,9)18-21-42/h10-15,22,25,36H,16-21,23-24H2,1-9H3,(H,43,44)/t36-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324163
PNG
(US10189816, Compound 156)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4ccc5OCCOc5c4)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C38H49N3O5/c1-24-32(34(41-16-13-38(6,7)14-17-41)33(25(2)39-24)35(36(42)43)46-37(3,4)5)28-9-10-29-23-40(15-12-27(29)21-28)22-26-8-11-30-31(20-26)45-19-18-44-30/h8-11,20-21,35H,12-19,22-23H2,1-7H3,(H,42,43)/t35-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324167
PNG
(US10189816, Compound 160)
Show SMILES CC(C)Oc1cc(C)c(CN2CCc3cc(ccc3C2)-c2c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c2N2CCC(C)(C)CC2)c(C)c1
Show InChI InChI=1S/C41H57N3O4/c1-25(2)47-33-20-26(3)34(27(4)21-33)24-43-17-14-30-22-31(12-13-32(30)23-43)35-28(5)42-29(6)36(38(39(45)46)48-40(7,8)9)37(35)44-18-15-41(10,11)16-19-44/h12-13,20-22,25,38H,14-19,23-24H2,1-11H3,(H,45,46)/t38-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324170
PNG
(US10189816, Compound 163)
Show SMILES CCCCCCCCCOc1ccc(CN2CCc3cc(ccc3C2)-c2c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c2N2CCC(C)(C)CC2)cc1
Show InChI InChI=1S/C45H65N3O4/c1-9-10-11-12-13-14-15-28-51-38-20-16-34(17-21-38)30-47-25-22-35-29-36(18-19-37(35)31-47)39-32(2)46-33(3)40(42(43(49)50)52-44(4,5)6)41(39)48-26-23-45(7,8)24-27-48/h16-21,29,42H,9-15,22-28,30-31H2,1-8H3,(H,49,50)/t42-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324171
PNG
(US10189816, Compound 164)
Show SMILES Cc1cccc(Cl)c1CN1CCc2cc(ccc2C1)-c1cnc(C)c([C@H](OC(C)(C)C)C(O)=O)c1N1CCC(C)(C)CC1
Show InChI InChI=1S/C36H46ClN3O3/c1-23-9-8-10-30(37)29(23)22-39-16-13-25-19-26(11-12-27(25)21-39)28-20-38-24(2)31(33(34(41)42)43-35(3,4)5)32(28)40-17-14-36(6,7)15-18-40/h8-12,19-20,33H,13-18,21-22H2,1-7H3,(H,41,42)/t33-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324012
PNG
(US10189816, Compound 5)
Show SMILES Cc1ccc(CN2CCc3cc(ccc3C2)-c2c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c2N2CCC(C)(C)CC2)cc1
Show InChI InChI=1S/C37H49N3O3/c1-24-9-11-27(12-10-24)22-39-18-15-28-21-29(13-14-30(28)23-39)31-25(2)38-26(3)32(34(35(41)42)43-36(4,5)6)33(31)40-19-16-37(7,8)17-20-40/h9-14,21,34H,15-20,22-23H2,1-8H3,(H,41,42)/t34-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324044
PNG
(US10189816, Compound 37)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4ccc(F)c(F)c4)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C36H45F2N3O3/c1-22-30(26-9-10-27-21-40(15-12-25(27)19-26)20-24-8-11-28(37)29(38)18-24)32(41-16-13-36(6,7)14-17-41)31(23(2)39-22)33(34(42)43)44-35(3,4)5/h8-11,18-19,33H,12-17,20-21H2,1-7H3,(H,42,43)/t33-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324055
PNG
(US10189816, Compound 48)
Show SMILES Cc1ccc(F)c(CN2CCc3cc(ccc3C2)-c2c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c2N2CCC(C)(C)CC2)c1F
Show InChI InChI=1S/C37H47F2N3O3/c1-22-9-12-29(38)28(32(22)39)21-41-16-13-25-19-26(10-11-27(25)20-41)30-23(2)40-24(3)31(34(35(43)44)45-36(4,5)6)33(30)42-17-14-37(7,8)15-18-42/h9-12,19,34H,13-18,20-21H2,1-8H3,(H,43,44)/t34-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324076
PNG
(US10189816, Compound 69)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4ccc(F)cc4C(F)(F)F)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C37H45F4N3O3/c1-22-30(32(44-16-13-36(6,7)14-17-44)31(23(2)42-22)33(34(45)46)47-35(3,4)5)25-8-9-26-20-43(15-12-24(26)18-25)21-27-10-11-28(38)19-29(27)37(39,40)41/h8-11,18-19,33H,12-17,20-21H2,1-7H3,(H,45,46)/t33-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324079
PNG
(US10189816, Compound 72)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4ccc(F)c(C)c4C)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C38H50FN3O3/c1-23-24(2)31(39)13-12-29(23)21-41-17-14-27-20-28(10-11-30(27)22-41)32-25(3)40-26(4)33(35(36(43)44)45-37(5,6)7)34(32)42-18-15-38(8,9)16-19-42/h10-13,20,35H,14-19,21-22H2,1-9H3,(H,43,44)/t35-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324089
PNG
(US10189816, Compound 82)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4cccc(F)c4C)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C37H48FN3O3/c1-23-28(10-9-11-30(23)38)21-40-17-14-26-20-27(12-13-29(26)22-40)31-24(2)39-25(3)32(34(35(42)43)44-36(4,5)6)33(31)41-18-15-37(7,8)16-19-41/h9-13,20,34H,14-19,21-22H2,1-8H3,(H,42,43)/t34-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324121
PNG
(US10189816, Compound 114)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4ccccc4OC(F)F)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C37H47F2N3O4/c1-23-30(26-12-13-27-21-41(17-14-25(27)20-26)22-28-10-8-9-11-29(28)45-35(38)39)32(42-18-15-37(6,7)16-19-42)31(24(2)40-23)33(34(43)44)46-36(3,4)5/h8-13,20,33,35H,14-19,21-22H2,1-7H3,(H,43,44)/t33-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324126
PNG
(US10189816, Compound 119)
Show SMILES COc1ccc(C)cc1CN1CCc2cc(ccc2C1)-c1c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c1N1CCC(C)(C)CC1
Show InChI InChI=1S/C38H51N3O4/c1-24-10-13-31(44-9)30(20-24)23-40-17-14-27-21-28(11-12-29(27)22-40)32-25(2)39-26(3)33(35(36(42)43)45-37(4,5)6)34(32)41-18-15-38(7,8)16-19-41/h10-13,20-21,35H,14-19,22-23H2,1-9H3,(H,42,43)/t35-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324130
PNG
(US10189816, Compound 123)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4ccccc4OC(F)(F)F)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C37H46F3N3O4/c1-23-30(32(43-18-15-36(6,7)16-19-43)31(24(2)41-23)33(34(44)45)47-35(3,4)5)26-12-13-27-21-42(17-14-25(27)20-26)22-28-10-8-9-11-29(28)46-37(38,39)40/h8-13,20,33H,14-19,21-22H2,1-7H3,(H,44,45)/t33-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324136
PNG
(US10189816, Compound 129)
Show SMILES COc1cccc(CN2CCc3cc(ccc3C2)-c2c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c2N2CCC(C)(C)CC2)c1Cl
Show InChI InChI=1S/C37H48ClN3O4/c1-23-30(26-12-13-27-21-40(17-14-25(27)20-26)22-28-10-9-11-29(44-8)32(28)38)33(41-18-15-37(6,7)16-19-41)31(24(2)39-23)34(35(42)43)45-36(3,4)5/h9-13,20,34H,14-19,21-22H2,1-8H3,(H,42,43)/t34-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324145
PNG
(US10189816, Compound 138)
Show SMILES COc1cc(CN2CCc3cc(ccc3C2)-c2c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c2N2CCC(C)(C)CC2)ccc1Cl
Show InChI InChI=1S/C37H48ClN3O4/c1-23-31(27-10-11-28-22-40(16-13-26(28)20-27)21-25-9-12-29(38)30(19-25)44-8)33(41-17-14-37(6,7)15-18-41)32(24(2)39-23)34(35(42)43)45-36(3,4)5/h9-12,19-20,34H,13-18,21-22H2,1-8H3,(H,42,43)/t34-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324151
PNG
(US10189816, Compound 144)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4c(O)cc(F)cc4F)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C36H45F2N3O4/c1-21-30(24-8-9-25-19-40(13-10-23(25)16-24)20-27-28(38)17-26(37)18-29(27)42)32(41-14-11-36(6,7)12-15-41)31(22(2)39-21)33(34(43)44)45-35(3,4)5/h8-9,16-18,33,42H,10-15,19-20H2,1-7H3,(H,43,44)/t33-/m0/s1
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n/an/an/an/a 8n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324156
PNG
(US10189816, Compound 149)
Show SMILES CCOc1ccc(CN2CCc3cc(ccc3C2)-c2c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c2N2CCC(C)(C)CC2)cc1
Show InChI InChI=1S/C38H51N3O4/c1-9-44-31-14-10-27(11-15-31)23-40-19-16-28-22-29(12-13-30(28)24-40)32-25(2)39-26(3)33(35(36(42)43)45-37(4,5)6)34(32)41-20-17-38(7,8)18-21-41/h10-15,22,35H,9,16-21,23-24H2,1-8H3,(H,42,43)/t35-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324014
PNG
(US10189816, Compound 7)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4cccc(F)c4)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C36H46FN3O3/c1-23-30(27-11-12-28-22-39(16-13-26(28)20-27)21-25-9-8-10-29(37)19-25)32(40-17-14-36(6,7)15-18-40)31(24(2)38-23)33(34(41)42)43-35(3,4)5/h8-12,19-20,33H,13-18,21-22H2,1-7H3,(H,41,42)/t33-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324016
PNG
(US10189816, Compound 9)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4ccccc4F)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C36H46FN3O3/c1-23-30(26-12-13-27-21-39(17-14-25(27)20-26)22-28-10-8-9-11-29(28)37)32(40-18-15-36(6,7)16-19-40)31(24(2)38-23)33(34(41)42)43-35(3,4)5/h8-13,20,33H,14-19,21-22H2,1-7H3,(H,41,42)/t33-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324018
PNG
(US10189816, Compound 11)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4cccc(c4)-c4ccccc4)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C42H51N3O3/c1-28-36(38(45-22-19-42(6,7)20-23-45)37(29(2)43-28)39(40(46)47)48-41(3,4)5)34-16-17-35-27-44(21-18-33(35)25-34)26-30-12-11-15-32(24-30)31-13-9-8-10-14-31/h8-17,24-25,39H,18-23,26-27H2,1-7H3,(H,46,47)/t39-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324028
PNG
(US10189816, Compound 21)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4cccc(F)c4F)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C36H45F2N3O3/c1-22-29(25-11-12-26-20-40(16-13-24(26)19-25)21-27-9-8-10-28(37)31(27)38)32(41-17-14-36(6,7)15-18-41)30(23(2)39-22)33(34(42)43)44-35(3,4)5/h8-12,19,33H,13-18,20-21H2,1-7H3,(H,42,43)/t33-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324030
PNG
(US10189816, Compound 23)
Show SMILES Cc1cccc(Cl)c1CN1CCc2cc(ccc2C1)-c1c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c1N1CCC(C)(C)CC1
Show InChI InChI=1S/C37H48ClN3O3/c1-23-10-9-11-30(38)29(23)22-40-17-14-26-20-27(12-13-28(26)21-40)31-24(2)39-25(3)32(34(35(42)43)44-36(4,5)6)33(31)41-18-15-37(7,8)16-19-41/h9-13,20,34H,14-19,21-22H2,1-8H3,(H,42,43)/t34-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324031
PNG
(US10189816, Compound 24)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4ccc(F)c(Cl)c4)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C36H45ClFN3O3/c1-22-30(26-9-10-27-21-40(15-12-25(27)19-26)20-24-8-11-29(38)28(37)18-24)32(41-16-13-36(6,7)14-17-41)31(23(2)39-22)33(34(42)43)44-35(3,4)5/h8-11,18-19,33H,12-17,20-21H2,1-7H3,(H,42,43)/t33-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324033
PNG
(US10189816, Compound 26)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4cc(Cl)cc(Cl)c4)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C36H45Cl2N3O3/c1-22-30(26-8-9-27-21-40(13-10-25(27)18-26)20-24-16-28(37)19-29(38)17-24)32(41-14-11-36(6,7)12-15-41)31(23(2)39-22)33(34(42)43)44-35(3,4)5/h8-9,16-19,33H,10-15,20-21H2,1-7H3,(H,42,43)/t33-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324040
PNG
(US10189816, Compound 33)
Show SMILES Cc1cccc(C)c1CN1CCc2cc(ccc2C1)-c1c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c1N1CCC(C)(C)CC1
Show InChI InChI=1S/C38H51N3O3/c1-24-11-10-12-25(2)31(24)23-40-18-15-28-21-29(13-14-30(28)22-40)32-26(3)39-27(4)33(35(36(42)43)44-37(5,6)7)34(32)41-19-16-38(8,9)17-20-41/h10-14,21,35H,15-20,22-23H2,1-9H3,(H,42,43)/t35-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324043
PNG
(US10189816, Compound 36)
Show SMILES CC(C)c1cccc(CN2CCc3cc(ccc3C2)-c2c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c2N2CCC(C)(C)CC2)c1
Show InChI InChI=1S/C39H53N3O3/c1-25(2)29-12-10-11-28(21-29)23-41-18-15-30-22-31(13-14-32(30)24-41)33-26(3)40-27(4)34(36(37(43)44)45-38(5,6)7)35(33)42-19-16-39(8,9)17-20-42/h10-14,21-22,25,36H,15-20,23-24H2,1-9H3,(H,43,44)/t36-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324053
PNG
(US10189816, Compound 46)
Show SMILES Cc1cc(F)cc(CN2CCc3cc(ccc3C2)-c2c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c2N2CCC(C)(C)CC2)c1
Show InChI InChI=1S/C37H48FN3O3/c1-23-17-26(19-30(38)18-23)21-40-14-11-27-20-28(9-10-29(27)22-40)31-24(2)39-25(3)32(34(35(42)43)44-36(4,5)6)33(31)41-15-12-37(7,8)13-16-41/h9-10,17-20,34H,11-16,21-22H2,1-8H3,(H,42,43)/t34-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324056
PNG
(US10189816, Compound 49)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4cc(F)c(F)cc4F)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C36H44F3N3O3/c1-21-30(24-8-9-25-19-41(13-10-23(25)16-24)20-26-17-28(38)29(39)18-27(26)37)32(42-14-11-36(6,7)12-15-42)31(22(2)40-21)33(34(43)44)45-35(3,4)5/h8-9,16-18,33H,10-15,19-20H2,1-7H3,(H,43,44)/t33-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324058
PNG
(US10189816, Compound 51)
Show SMILES Cc1cccc(F)c1CN1CCc2cc(ccc2C1)-c1c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c1N1CCC(C)(C)CC1
Show InChI InChI=1S/C37H48FN3O3/c1-23-10-9-11-30(38)29(23)22-40-17-14-26-20-27(12-13-28(26)21-40)31-24(2)39-25(3)32(34(35(42)43)44-36(4,5)6)33(31)41-18-15-37(7,8)16-19-41/h9-13,20,34H,14-19,21-22H2,1-8H3,(H,42,43)/t34-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324059
PNG
(US10189816, Compound 52 | US10189816, Compound 70)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4cc(ccc4F)C(F)(F)F)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C37H45F4N3O3/c1-22-30(32(44-16-13-36(6,7)14-17-44)31(23(2)42-22)33(34(45)46)47-35(3,4)5)25-8-9-26-20-43(15-12-24(26)18-25)21-27-19-28(37(39,40)41)10-11-29(27)38/h8-11,18-19,33H,12-17,20-21H2,1-7H3,(H,45,46)/t33-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324064
PNG
(US10189816, Compound 57)
Show SMILES Cc1cc(C)c(CN2CCc3cc(ccc3C2)-c2c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c2N2CCC(C)(C)CC2)c(C)c1
Show InChI InChI=1S/C39H53N3O3/c1-24-19-25(2)32(26(3)20-24)23-41-16-13-29-21-30(11-12-31(29)22-41)33-27(4)40-28(5)34(36(37(43)44)45-38(6,7)8)35(33)42-17-14-39(9,10)15-18-42/h11-12,19-21,36H,13-18,22-23H2,1-10H3,(H,43,44)/t36-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324068
PNG
(US10189816, Compound 61)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4cccc(c4)C#N)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C37H46N4O3/c1-24-31(29-11-12-30-23-40(16-13-28(30)20-29)22-27-10-8-9-26(19-27)21-38)33(41-17-14-37(6,7)15-18-41)32(25(2)39-24)34(35(42)43)44-36(3,4)5/h8-12,19-20,34H,13-18,22-23H2,1-7H3,(H,42,43)/t34-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324073
PNG
(US10189816, Compound 66)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4cc(F)ccc4C(F)(F)F)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C37H45F4N3O3/c1-22-30(32(44-16-13-36(6,7)14-17-44)31(23(2)42-22)33(34(45)46)47-35(3,4)5)25-8-9-26-20-43(15-12-24(26)18-25)21-27-19-28(38)10-11-29(27)37(39,40)41/h8-11,18-19,33H,12-17,20-21H2,1-7H3,(H,45,46)/t33-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324081
PNG
(US10189816, Compound 74)
Show SMILES Cc1ccc(F)c(CN2CCc3cc(ccc3C2)-c2c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c2N2CCC(C)(C)CC2)c1
Show InChI InChI=1S/C37H48FN3O3/c1-23-9-12-30(38)29(19-23)22-40-16-13-26-20-27(10-11-28(26)21-40)31-24(2)39-25(3)32(34(35(42)43)44-36(4,5)6)33(31)41-17-14-37(7,8)15-18-41/h9-12,19-20,34H,13-18,21-22H2,1-8H3,(H,42,43)/t34-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324092
PNG
(US10189816, Compound 85)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4cc(Cl)cc(Cl)c4OCc4ccccc4)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C43H51Cl2N3O4/c1-27-36(38(48-19-16-43(6,7)17-20-48)37(28(2)46-27)40(41(49)50)52-42(3,4)5)31-13-14-32-24-47(18-15-30(32)21-31)25-33-22-34(44)23-35(45)39(33)51-26-29-11-9-8-10-12-29/h8-14,21-23,40H,15-20,24-26H2,1-7H3,(H,49,50)/t40-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324093
PNG
(US10189816, Compound 86)
Show SMILES COc1cc(F)c(F)cc1CN1CCc2cc(ccc2C1)-c1c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c1N1CCC(C)(C)CC1
Show InChI InChI=1S/C37H47F2N3O4/c1-22-31(25-9-10-26-20-41(14-11-24(26)17-25)21-27-18-28(38)29(39)19-30(27)45-8)33(42-15-12-37(6,7)13-16-42)32(23(2)40-22)34(35(43)44)46-36(3,4)5/h9-10,17-19,34H,11-16,20-21H2,1-8H3,(H,43,44)/t34-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324102
PNG
(US10189816, Compound 95)
Show SMILES COc1c(F)cc(CN2CCc3cc(ccc3C2)-c2c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c2N2CCC(C)(C)CC2)cc1F
Show InChI InChI=1S/C37H47F2N3O4/c1-22-30(26-9-10-27-21-41(14-11-25(27)19-26)20-24-17-28(38)33(45-8)29(39)18-24)32(42-15-12-37(6,7)13-16-42)31(23(2)40-22)34(35(43)44)46-36(3,4)5/h9-10,17-19,34H,11-16,20-21H2,1-8H3,(H,43,44)/t34-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324105
PNG
(US10189816, Compound 98)
Show SMILES COc1c(CN2CCc3cc(ccc3C2)-c2c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c2N2CCC(C)(C)CC2)cccc1C(F)(F)F
Show InChI InChI=1S/C38H48F3N3O4/c1-23-30(32(44-18-15-37(6,7)16-19-44)31(24(2)42-23)34(35(45)46)48-36(3,4)5)26-12-13-27-21-43(17-14-25(27)20-26)22-28-10-9-11-29(33(28)47-8)38(39,40)41/h9-13,20,34H,14-19,21-22H2,1-8H3,(H,45,46)/t34-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324106
PNG
(US10189816, Compound 99)
Show SMILES COc1ccc(Cl)cc1CN1CCc2cc(ccc2C1)-c1c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c1N1CCC(C)(C)CC1
Show InChI InChI=1S/C37H48ClN3O4/c1-23-31(26-9-10-27-21-40(16-13-25(27)19-26)22-28-20-29(38)11-12-30(28)44-8)33(41-17-14-37(6,7)15-18-41)32(24(2)39-23)34(35(42)43)45-36(3,4)5/h9-12,19-20,34H,13-18,21-22H2,1-8H3,(H,42,43)/t34-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324096
PNG
(US10189816, Compound 107 | US10189816, Compound 89)
Show SMILES COc1cc(F)cc(F)c1CN1CCc2cc(ccc2C1)-c1c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c1N1CCC(C)(C)CC1
Show InChI InChI=1S/C37H47F2N3O4/c1-22-31(25-9-10-26-20-41(14-11-24(26)17-25)21-28-29(39)18-27(38)19-30(28)45-8)33(42-15-12-37(6,7)13-16-42)32(23(2)40-22)34(35(43)44)46-36(3,4)5/h9-10,17-19,34H,11-16,20-21H2,1-8H3,(H,43,44)/t34-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324115
PNG
(US10189816, Compound 108)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4ccc(OC(F)(F)F)c(F)c4)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C37H45F4N3O4/c1-22-30(32(44-16-13-36(6,7)14-17-44)31(23(2)42-22)33(34(45)46)48-35(3,4)5)26-9-10-27-21-43(15-12-25(27)19-26)20-24-8-11-29(28(38)18-24)47-37(39,40)41/h8-11,18-19,33H,12-17,20-21H2,1-7H3,(H,45,46)/t33-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324117
PNG
(US10189816, Compound 110)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4cccc(OC(F)(F)F)c4)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C37H46F3N3O4/c1-23-30(32(43-17-14-36(6,7)15-18-43)31(24(2)41-23)33(34(44)45)47-35(3,4)5)27-11-12-28-22-42(16-13-26(28)20-27)21-25-9-8-10-29(19-25)46-37(38,39)40/h8-12,19-20,33H,13-18,21-22H2,1-7H3,(H,44,45)/t33-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324119
PNG
(US10189816, Compound 112)
Show SMILES COc1cc(CN2CCc3cc(ccc3C2)-c2c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c2N2CCC(C)(C)CC2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C38H48F3N3O4/c1-23-31(33(44-15-12-37(6,7)13-16-44)32(24(2)42-23)34(35(45)46)48-36(3,4)5)27-9-10-28-22-43(14-11-26(28)19-27)21-25-17-29(38(39,40)41)20-30(18-25)47-8/h9-10,17-20,34H,11-16,21-22H2,1-8H3,(H,45,46)/t34-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324120
PNG
(US10189816, Compound 113)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4cc(Cl)cc(OC(F)(F)F)c4)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C37H45ClF3N3O4/c1-22-30(32(44-14-11-36(6,7)12-15-44)31(23(2)42-22)33(34(45)46)48-35(3,4)5)26-8-9-27-21-43(13-10-25(27)18-26)20-24-16-28(38)19-29(17-24)47-37(39,40)41/h8-9,16-19,33H,10-15,20-21H2,1-7H3,(H,45,46)/t33-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324129
PNG
(US10189816, Compound 122)
Show SMILES COc1cc(F)cc(CN2CCc3cc(ccc3C2)-c2c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c2N2CCC(C)(C)CC2)c1
Show InChI InChI=1S/C37H48FN3O4/c1-23-31(27-9-10-28-22-40(14-11-26(28)19-27)21-25-17-29(38)20-30(18-25)44-8)33(41-15-12-37(6,7)13-16-41)32(24(2)39-23)34(35(42)43)45-36(3,4)5/h9-10,17-20,34H,11-16,21-22H2,1-8H3,(H,42,43)/t34-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324131
PNG
(US10189816, Compound 124)
Show SMILES COc1ccc(F)cc1CN1CCc2cc(ccc2C1)-c1c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c1N1CCC(C)(C)CC1
Show InChI InChI=1S/C37H48FN3O4/c1-23-31(26-9-10-27-21-40(16-13-25(27)19-26)22-28-20-29(38)11-12-30(28)44-8)33(41-17-14-37(6,7)15-18-41)32(24(2)39-23)34(35(42)43)45-36(3,4)5/h9-12,19-20,34H,13-18,21-22H2,1-8H3,(H,42,43)/t34-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324133
PNG
(US10189816, Compound 126)
Show SMILES CCOc1cc(CN2CCc3cc(ccc3C2)-c2c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c2N2CCC(C)(C)CC2)c(F)cc1F
Show InChI InChI=1S/C38H49F2N3O4/c1-9-46-31-19-28(29(39)20-30(31)40)22-42-15-12-25-18-26(10-11-27(25)21-42)32-23(2)41-24(3)33(35(36(44)45)47-37(4,5)6)34(32)43-16-13-38(7,8)14-17-43/h10-11,18-20,35H,9,12-17,21-22H2,1-8H3,(H,44,45)/t35-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324151
PNG
(US10189816, Compound 144)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4c(O)cc(F)cc4F)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C36H45F2N3O4/c1-21-30(24-8-9-25-19-40(13-10-23(25)16-24)20-27-28(38)17-26(37)18-29(27)42)32(41-14-11-36(6,7)12-15-41)31(22(2)39-21)33(34(43)44)45-35(3,4)5/h8-9,16-18,33,42H,10-15,19-20H2,1-7H3,(H,43,44)/t33-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324157
PNG
(US10189816, Compound 150)
Show SMILES CC(C)Oc1ccc(CN2CCc3cc(ccc3C2)-c2c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c2N2CCC(C)(C)CC2)cc1
Show InChI InChI=1S/C39H53N3O4/c1-25(2)45-32-14-10-28(11-15-32)23-41-19-16-29-22-30(12-13-31(29)24-41)33-26(3)40-27(4)34(36(37(43)44)46-38(5,6)7)35(33)42-20-17-39(8,9)18-21-42/h10-15,22,25,36H,16-21,23-24H2,1-9H3,(H,43,44)/t36-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324157
PNG
(US10189816, Compound 150)
Show SMILES CC(C)Oc1ccc(CN2CCc3cc(ccc3C2)-c2c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c2N2CCC(C)(C)CC2)cc1
Show InChI InChI=1S/C39H53N3O4/c1-25(2)45-32-14-10-28(11-15-32)23-41-19-16-29-22-30(12-13-31(29)24-41)33-26(3)40-27(4)34(36(37(43)44)46-38(5,6)7)35(33)42-20-17-39(8,9)18-21-42/h10-15,22,25,36H,16-21,23-24H2,1-9H3,(H,43,44)/t36-/m0/s1
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n/an/an/an/a 21n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324166
PNG
(US10189816, Compound 159)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4c(F)cccc4Oc4ccccc4)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C42H50FN3O4/c1-27-36(38(46-22-19-42(6,7)20-23-46)37(28(2)44-27)39(40(47)48)50-41(3,4)5)30-16-17-31-25-45(21-18-29(31)24-30)26-33-34(43)14-11-15-35(33)49-32-12-9-8-10-13-32/h8-17,24,39H,18-23,25-26H2,1-7H3,(H,47,48)/t39-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324172
PNG
(US10189816, Compound 165)
Show SMILES Cc1ccccc1CN1CCc2cc(ccc2C1)-c1cnc(C)c([C@H](OC(C)(C)C)C(O)=O)c1N1CCC(C)(C)CC1
Show InChI InChI=1S/C36H47N3O3/c1-24-10-8-9-11-28(24)22-38-17-14-26-20-27(12-13-29(26)23-38)30-21-37-25(2)31(33(34(40)41)42-35(3,4)5)32(30)39-18-15-36(6,7)16-19-39/h8-13,20-21,33H,14-19,22-23H2,1-7H3,(H,40,41)/t33-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324173
PNG
(US10189816, Compound 166)
Show SMILES Cc1cccc(Cl)c1CN1CCc2cc(ccc2C1)-c1c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c1N1CCCC(C)(C)C1
Show InChI InChI=1S/C37H48ClN3O3/c1-23-11-9-12-30(38)29(23)21-40-18-15-26-19-27(13-14-28(26)20-40)31-24(2)39-25(3)32(34(35(42)43)44-36(4,5)6)33(31)41-17-10-16-37(7,8)22-41/h9,11-14,19,34H,10,15-18,20-22H2,1-8H3,(H,42,43)/t34-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM323830
PNG
(US10189816, Compound 1)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4ccc(F)cc4)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C36H46FN3O3/c1-23-30(27-10-11-28-22-39(17-14-26(28)20-27)21-25-8-12-29(37)13-9-25)32(40-18-15-36(6,7)16-19-40)31(24(2)38-23)33(34(41)42)43-35(3,4)5/h8-13,20,33H,14-19,21-22H2,1-7H3,(H,41,42)/t33-/m0/s1
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n/an/an/an/a 6n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324009
PNG
(US10189816, Compound 2)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4cccc(c4)C(F)(F)F)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C37H46F3N3O3/c1-23-30(27-11-12-28-22-42(16-13-26(28)20-27)21-25-9-8-10-29(19-25)37(38,39)40)32(43-17-14-36(6,7)15-18-43)31(24(2)41-23)33(34(44)45)46-35(3,4)5/h8-12,19-20,33H,13-18,21-22H2,1-7H3,(H,44,45)/t33-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324014
PNG
(US10189816, Compound 7)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4cccc(F)c4)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C36H46FN3O3/c1-23-30(27-11-12-28-22-39(16-13-26(28)20-27)21-25-9-8-10-29(37)19-25)32(40-17-14-36(6,7)15-18-40)31(24(2)38-23)33(34(41)42)43-35(3,4)5/h8-12,19-20,33H,13-18,21-22H2,1-7H3,(H,41,42)/t33-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324019
PNG
(US10189816, Compound 12)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4ccccc4C(F)(F)F)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C37H46F3N3O3/c1-23-30(26-12-13-27-21-42(17-14-25(27)20-26)22-28-10-8-9-11-29(28)37(38,39)40)32(43-18-15-36(6,7)16-19-43)31(24(2)41-23)33(34(44)45)46-35(3,4)5/h8-13,20,33H,14-19,21-22H2,1-7H3,(H,44,45)/t33-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324020
PNG
(US10189816, Compound 13)
Show SMILES CC(N1CCc2cc(ccc2C1)-c1c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c1N1CCC(C)(C)CC1)c1ccccc1
Show InChI InChI=1S/C37H49N3O3/c1-24-31(29-14-15-30-23-40(19-16-28(30)22-29)26(3)27-12-10-9-11-13-27)33(39-20-17-37(7,8)18-21-39)32(25(2)38-24)34(35(41)42)43-36(4,5)6/h9-15,22,26,34H,16-21,23H2,1-8H3,(H,41,42)/t26?,34-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324023
PNG
(US10189816, Compound 16)
Show SMILES Cc1ccc(CN2CCc3cc(ccc3C2)-c2c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c2N2CCC(C)(C)CC2)cc1C(F)(F)F
Show InChI InChI=1S/C38H48F3N3O3/c1-23-9-10-26(19-30(23)38(39,40)41)21-43-16-13-27-20-28(11-12-29(27)22-43)31-24(2)42-25(3)32(34(35(45)46)47-36(4,5)6)33(31)44-17-14-37(7,8)15-18-44/h9-12,19-20,34H,13-18,21-22H2,1-8H3,(H,45,46)/t34-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324024
PNG
(US10189816, Compound 161 | US10189816, Compound 17)
Show SMILES Cc1ccc(CN2CCc3cc(ccc3C2)-c2c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c2N2CCC(C)(C)CC2)cc1C
Show InChI InChI=1S/C38H51N3O3/c1-24-10-11-28(20-25(24)2)22-40-17-14-29-21-30(12-13-31(29)23-40)32-26(3)39-27(4)33(35(36(42)43)44-37(5,6)7)34(32)41-18-15-38(8,9)16-19-41/h10-13,20-21,35H,14-19,22-23H2,1-9H3,(H,42,43)/t35-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324029
PNG
(US10189816, Compound 22)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4ccc(Cl)c(F)c4)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C36H45ClFN3O3/c1-22-30(26-9-10-27-21-40(15-12-25(27)19-26)20-24-8-11-28(37)29(38)18-24)32(41-16-13-36(6,7)14-17-41)31(23(2)39-22)33(34(42)43)44-35(3,4)5/h8-11,18-19,33H,12-17,20-21H2,1-7H3,(H,42,43)/t33-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324038
PNG
(US10189816, Compound 31)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4cc(F)cc(F)c4)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C36H45F2N3O3/c1-22-30(26-8-9-27-21-40(13-10-25(27)18-26)20-24-16-28(37)19-29(38)17-24)32(41-14-11-36(6,7)12-15-41)31(23(2)39-22)33(34(42)43)44-35(3,4)5/h8-9,16-19,33H,10-15,20-21H2,1-7H3,(H,42,43)/t33-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324047
PNG
(US10189816, Compound 40)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4cccc(Cl)c4Cl)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C36H45Cl2N3O3/c1-22-29(25-11-12-26-20-40(16-13-24(26)19-25)21-27-9-8-10-28(37)31(27)38)32(41-17-14-36(6,7)15-18-41)30(23(2)39-22)33(34(42)43)44-35(3,4)5/h8-12,19,33H,13-18,20-21H2,1-7H3,(H,42,43)/t33-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324066
PNG
(US10189816, Compound 59)
Show SMILES CC(C)c1ccc(CN2CCc3cc(ccc3C2)-c2c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c2N2CCC(C)(C)CC2)cc1
Show InChI InChI=1S/C39H53N3O3/c1-25(2)29-12-10-28(11-13-29)23-41-19-16-30-22-31(14-15-32(30)24-41)33-26(3)40-27(4)34(36(37(43)44)45-38(5,6)7)35(33)42-20-17-39(8,9)18-21-42/h10-15,22,25,36H,16-21,23-24H2,1-9H3,(H,43,44)/t36-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324070
PNG
(US10189816, Compound 63)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4cc(ccc4F)C#N)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C37H45FN4O3/c1-23-31(27-9-10-28-21-41(15-12-26(28)19-27)22-29-18-25(20-39)8-11-30(29)38)33(42-16-13-37(6,7)14-17-42)32(24(2)40-23)34(35(43)44)45-36(3,4)5/h8-11,18-19,34H,12-17,21-22H2,1-7H3,(H,43,44)/t34-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324059
PNG
(US10189816, Compound 52 | US10189816, Compound 70)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4cc(ccc4F)C(F)(F)F)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C37H45F4N3O3/c1-22-30(32(44-16-13-36(6,7)14-17-44)31(23(2)42-22)33(34(45)46)47-35(3,4)5)25-8-9-26-20-43(15-12-24(26)18-25)21-27-19-28(37(39,40)41)10-11-29(27)38/h8-11,18-19,33H,12-17,20-21H2,1-7H3,(H,45,46)/t33-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324082
PNG
(US10189816, Compound 75)
Show SMILES Cc1cc(CN2CCc3cc(ccc3C2)-c2c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c2N2CCC(C)(C)CC2)cc(C)c1F
Show InChI InChI=1S/C38H50FN3O3/c1-23-18-27(19-24(2)33(23)39)21-41-15-12-28-20-29(10-11-30(28)22-41)31-25(3)40-26(4)32(35(36(43)44)45-37(5,6)7)34(31)42-16-13-38(8,9)14-17-42/h10-11,18-20,35H,12-17,21-22H2,1-9H3,(H,43,44)/t35-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324110
PNG
(US10189816, Compound 103)
Show SMILES CCOc1cccc(CN2CCc3cc(ccc3C2)-c2c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c2N2CCC(C)(C)CC2)c1
Show InChI InChI=1S/C38H51N3O4/c1-9-44-31-12-10-11-27(21-31)23-40-18-15-28-22-29(13-14-30(28)24-40)32-25(2)39-26(3)33(35(36(42)43)45-37(4,5)6)34(32)41-19-16-38(7,8)17-20-41/h10-14,21-22,35H,9,15-20,23-24H2,1-8H3,(H,42,43)/t35-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324091
PNG
(US10189816, Compound 106 | US10189816, Compound 84)
Show SMILES COc1cc(F)c(CN2CCc3cc(ccc3C2)-c2c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c2N2CCC(C)(C)CC2)c(F)c1
Show InChI InChI=1S/C37H47F2N3O4/c1-22-31(25-9-10-26-20-41(14-11-24(26)17-25)21-28-29(38)18-27(45-8)19-30(28)39)33(42-15-12-37(6,7)13-16-42)32(23(2)40-22)34(35(43)44)46-36(3,4)5/h9-10,17-19,34H,11-16,20-21H2,1-8H3,(H,43,44)/t34-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324122
PNG
(US10189816, Compound 115)
Show SMILES COc1cccc(F)c1CN1CCc2cc(ccc2C1)-c1c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c1N1CCC(C)(C)CC1
Show InChI InChI=1S/C37H48FN3O4/c1-23-31(26-12-13-27-21-40(17-14-25(27)20-26)22-28-29(38)10-9-11-30(28)44-8)33(41-18-15-37(6,7)16-19-41)32(24(2)39-23)34(35(42)43)45-36(3,4)5/h9-13,20,34H,14-19,21-22H2,1-8H3,(H,42,43)/t34-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324123
PNG
(US10189816, Compound 116)
Show SMILES COc1ccc(F)c(CN2CCc3cc(ccc3C2)-c2c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c2N2CCC(C)(C)CC2)c1
Show InChI InChI=1S/C37H48FN3O4/c1-23-31(26-9-10-27-21-40(16-13-25(27)19-26)22-28-20-29(44-8)11-12-30(28)38)33(41-17-14-37(6,7)15-18-41)32(24(2)39-23)34(35(42)43)45-36(3,4)5/h9-12,19-20,34H,13-18,21-22H2,1-8H3,(H,42,43)/t34-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324124
PNG
(US10189816, Compound 117)
Show SMILES COc1cc(F)ccc1CN1CCc2cc(ccc2C1)-c1c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c1N1CCC(C)(C)CC1
Show InChI InChI=1S/C37H48FN3O4/c1-23-31(26-9-10-27-21-40(16-13-25(27)19-26)22-28-11-12-29(38)20-30(28)44-8)33(41-17-14-37(6,7)15-18-41)32(24(2)39-23)34(35(42)43)45-36(3,4)5/h9-12,19-20,34H,13-18,21-22H2,1-8H3,(H,42,43)/t34-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324134
PNG
(US10189816, Compound 127)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4ccc(Cl)c(Cl)c4)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C36H45Cl2N3O3/c1-22-30(26-9-10-27-21-40(15-12-25(27)19-26)20-24-8-11-28(37)29(38)18-24)32(41-16-13-36(6,7)14-17-41)31(23(2)39-22)33(34(42)43)44-35(3,4)5/h8-11,18-19,33H,12-17,20-21H2,1-7H3,(H,42,43)/t33-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324136
PNG
(US10189816, Compound 129)
Show SMILES COc1cccc(CN2CCc3cc(ccc3C2)-c2c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c2N2CCC(C)(C)CC2)c1Cl
Show InChI InChI=1S/C37H48ClN3O4/c1-23-30(26-12-13-27-21-40(17-14-25(27)20-26)22-28-10-9-11-29(44-8)32(28)38)33(41-18-15-37(6,7)16-19-41)31(24(2)39-23)34(35(42)43)45-36(3,4)5/h9-13,20,34H,14-19,21-22H2,1-8H3,(H,42,43)/t34-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324137
PNG
(US10189816, Compound 130)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4cccc(Cl)c4F)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C36H45ClFN3O3/c1-22-29(25-11-12-26-20-40(16-13-24(26)19-25)21-27-9-8-10-28(37)31(27)38)32(41-17-14-36(6,7)15-18-41)30(23(2)39-22)33(34(42)43)44-35(3,4)5/h8-12,19,33H,13-18,20-21H2,1-7H3,(H,42,43)/t33-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324141
PNG
(US10189816, Compound 134)
Show SMILES Cc1cc(CN2CCc3cc(ccc3C2)-c2c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c2N2CCC(C)(C)CC2)ccc1Cl
Show InChI InChI=1S/C37H48ClN3O3/c1-23-19-26(9-12-30(23)38)21-40-16-13-27-20-28(10-11-29(27)22-40)31-24(2)39-25(3)32(34(35(42)43)44-36(4,5)6)33(31)41-17-14-37(7,8)15-18-41/h9-12,19-20,34H,13-18,21-22H2,1-8H3,(H,42,43)/t34-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324024
PNG
(US10189816, Compound 161 | US10189816, Compound 17)
Show SMILES Cc1ccc(CN2CCc3cc(ccc3C2)-c2c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c2N2CCC(C)(C)CC2)cc1C
Show InChI InChI=1S/C38H51N3O3/c1-24-10-11-28(20-25(24)2)22-40-17-14-29-21-30(12-13-31(29)23-40)32-26(3)39-27(4)33(35(36(42)43)44-37(5,6)7)34(32)41-18-15-38(8,9)16-19-41/h10-13,20-21,35H,14-19,22-23H2,1-9H3,(H,42,43)/t35-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324010
PNG
(US10189816, Compound 3)
Show SMILES Cc1cccc(CN2CCc3cc(ccc3C2)-c2c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c2N2CCC(C)(C)CC2)c1
Show InChI InChI=1S/C37H49N3O3/c1-24-10-9-11-27(20-24)22-39-17-14-28-21-29(12-13-30(28)23-39)31-25(2)38-26(3)32(34(35(41)42)43-36(4,5)6)33(31)40-18-15-37(7,8)16-19-40/h9-13,20-21,34H,14-19,22-23H2,1-8H3,(H,41,42)/t34-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324015
PNG
(US10189816, Compound 8)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4ccc(cc4)C(F)(F)F)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C37H46F3N3O3/c1-23-30(27-10-11-28-22-42(17-14-26(28)20-27)21-25-8-12-29(13-9-25)37(38,39)40)32(43-18-15-36(6,7)16-19-43)31(24(2)41-23)33(34(44)45)46-35(3,4)5/h8-13,20,33H,14-19,21-22H2,1-7H3,(H,44,45)/t33-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324021
PNG
(US10189816, Compound 14)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4ccc(cc4)-c4ccccc4)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C42H51N3O3/c1-28-36(38(45-23-20-42(6,7)21-24-45)37(29(2)43-28)39(40(46)47)48-41(3,4)5)34-17-18-35-27-44(22-19-33(35)25-34)26-30-13-15-32(16-14-30)31-11-9-8-10-12-31/h8-18,25,39H,19-24,26-27H2,1-7H3,(H,46,47)/t39-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324021
PNG
(US10189816, Compound 14)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4ccc(cc4)-c4ccccc4)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C42H51N3O3/c1-28-36(38(45-23-20-42(6,7)21-24-45)37(29(2)43-28)39(40(46)47)48-41(3,4)5)34-17-18-35-27-44(22-19-33(35)25-34)26-30-13-15-32(16-14-30)31-11-9-8-10-12-31/h8-18,25,39H,19-24,26-27H2,1-7H3,(H,46,47)/t39-/m0/s1
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n/an/an/an/a 34n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324042
PNG
(US10189816, Compound 35)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4ccc(F)cc4Cl)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C36H45ClFN3O3/c1-22-30(25-8-9-26-20-40(15-12-24(26)18-25)21-27-10-11-28(38)19-29(27)37)32(41-16-13-36(6,7)14-17-41)31(23(2)39-22)33(34(42)43)44-35(3,4)5/h8-11,18-19,33H,12-17,20-21H2,1-7H3,(H,42,43)/t33-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324045
PNG
(US10189816, Compound 38)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4cc(F)ccc4F)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C36H45F2N3O3/c1-22-30(25-8-9-26-20-40(15-12-24(26)18-25)21-27-19-28(37)10-11-29(27)38)32(41-16-13-36(6,7)14-17-41)31(23(2)39-22)33(34(42)43)44-35(3,4)5/h8-11,18-19,33H,12-17,20-21H2,1-7H3,(H,42,43)/t33-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324046
PNG
(US10189816, Compound 39)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4ccc(Cl)cc4F)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C36H45ClFN3O3/c1-22-30(25-8-9-26-20-40(15-12-24(26)18-25)21-27-10-11-28(37)19-29(27)38)32(41-16-13-36(6,7)14-17-41)31(23(2)39-22)33(34(42)43)44-35(3,4)5/h8-11,18-19,33H,12-17,20-21H2,1-7H3,(H,42,43)/t33-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324057
PNG
(US10189816, Compound 50)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4c(F)cccc4F)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C36H45F2N3O3/c1-22-30(25-11-12-26-20-40(16-13-24(26)19-25)21-27-28(37)9-8-10-29(27)38)32(41-17-14-36(6,7)15-18-41)31(23(2)39-22)33(34(42)43)44-35(3,4)5/h8-12,19,33H,13-18,20-21H2,1-7H3,(H,42,43)/t33-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324062
PNG
(US10189816, Compound 55)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4ccccc4Cl)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C36H46ClN3O3/c1-23-30(26-12-13-27-21-39(17-14-25(27)20-26)22-28-10-8-9-11-29(28)37)32(40-18-15-36(6,7)16-19-40)31(24(2)38-23)33(34(41)42)43-35(3,4)5/h8-13,20,33H,14-19,21-22H2,1-7H3,(H,41,42)/t33-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324072
PNG
(US10189816, Compound 65)
Show SMILES Cc1cc(ccc1CN1CCc2cc(ccc2C1)-c1c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c1N1CCC(C)(C)CC1)C#N
Show InChI InChI=1S/C38H48N4O3/c1-24-19-27(21-39)9-10-30(24)22-41-16-13-28-20-29(11-12-31(28)23-41)32-25(2)40-26(3)33(35(36(43)44)45-37(4,5)6)34(32)42-17-14-38(7,8)15-18-42/h9-12,19-20,35H,13-18,22-23H2,1-8H3,(H,43,44)/t35-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324095
PNG
(US10189816, Compound 88)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4ccccc4OCCO)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C38H51N3O5/c1-25-32(28-12-13-29-23-40(17-14-27(29)22-28)24-30-10-8-9-11-31(30)45-21-20-42)34(41-18-15-38(6,7)16-19-41)33(26(2)39-25)35(36(43)44)46-37(3,4)5/h8-13,22,35,42H,14-21,23-24H2,1-7H3,(H,43,44)/t35-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324099
PNG
(US10189816, Compound 92)
Show SMILES COc1ccc(F)c(CN2CCc3cc(ccc3C2)-c2c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c2N2CCC(C)(C)CC2)c1F
Show InChI InChI=1S/C37H47F2N3O4/c1-22-30(25-9-10-26-20-41(16-13-24(26)19-25)21-27-28(38)11-12-29(45-8)32(27)39)33(42-17-14-37(6,7)15-18-42)31(23(2)40-22)34(35(43)44)46-36(3,4)5/h9-12,19,34H,13-18,20-21H2,1-8H3,(H,43,44)/t34-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324117
PNG
(US10189816, Compound 110)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4cccc(OC(F)(F)F)c4)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C37H46F3N3O4/c1-23-30(32(43-17-14-36(6,7)15-18-43)31(24(2)41-23)33(34(44)45)47-35(3,4)5)27-11-12-28-22-42(16-13-26(28)20-27)21-25-9-8-10-29(19-25)46-37(38,39)40/h8-12,19-20,33H,13-18,21-22H2,1-7H3,(H,44,45)/t33-/m0/s1
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n/an/an/an/a 8n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324125
PNG
(US10189816, Compound 118)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4cccc(OC(F)F)c4)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C37H47F2N3O4/c1-23-30(27-11-12-28-22-41(16-13-26(28)20-27)21-25-9-8-10-29(19-25)45-35(38)39)32(42-17-14-37(6,7)15-18-42)31(24(2)40-23)33(34(43)44)46-36(3,4)5/h8-12,19-20,33,35H,13-18,21-22H2,1-7H3,(H,43,44)/t33-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324130
PNG
(US10189816, Compound 123)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4ccccc4OC(F)(F)F)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C37H46F3N3O4/c1-23-30(32(43-18-15-36(6,7)16-19-43)31(24(2)41-23)33(34(44)45)47-35(3,4)5)26-12-13-27-21-42(17-14-25(27)20-26)22-28-10-8-9-11-29(28)46-37(38,39)40/h8-13,20,33H,14-19,21-22H2,1-7H3,(H,44,45)/t33-/m0/s1
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n/an/an/an/a 11n/an/an/an/a



ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324135
PNG
(US10189816, Compound 128)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4c(Cl)cccc4Cl)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C36H45Cl2N3O3/c1-22-30(25-11-12-26-20-40(16-13-24(26)19-25)21-27-28(37)9-8-10-29(27)38)32(41-17-14-36(6,7)15-18-41)31(23(2)39-22)33(34(42)43)44-35(3,4)5/h8-12,19,33H,13-18,20-21H2,1-7H3,(H,42,43)/t33-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324144
PNG
(US10189816, Compound 137)
Show SMILES COc1ccc(CN2CCc3cc(ccc3C2)-c2c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c2N2CCC(C)(C)CC2)cc1Cl
Show InChI InChI=1S/C37H48ClN3O4/c1-23-31(27-10-11-28-22-40(16-13-26(28)20-27)21-25-9-12-30(44-8)29(38)19-25)33(41-17-14-37(6,7)15-18-41)32(24(2)39-23)34(35(42)43)45-36(3,4)5/h9-12,19-20,34H,13-18,21-22H2,1-8H3,(H,42,43)/t34-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324146
PNG
(US10189816, Compound 139)
Show SMILES COc1ccc(cc1CN1CCc2cc(ccc2C1)-c1c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c1N1CCC(C)(C)CC1)C(C)C
Show InChI InChI=1S/C40H55N3O4/c1-25(2)28-13-14-33(46-10)32(21-28)24-42-18-15-29-22-30(11-12-31(29)23-42)34-26(3)41-27(4)35(37(38(44)45)47-39(5,6)7)36(34)43-19-16-40(8,9)17-20-43/h11-14,21-22,25,37H,15-20,23-24H2,1-10H3,(H,44,45)/t37-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324160
PNG
(US10189816, Compound 153)
Show SMILES CC(C)COc1ccccc1CN1CCc2cc(ccc2C1)-c1c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c1N1CCC(C)(C)CC1
Show InChI InChI=1S/C40H55N3O4/c1-26(2)25-46-33-13-11-10-12-32(33)24-42-19-16-29-22-30(14-15-31(29)23-42)34-27(3)41-28(4)35(37(38(44)45)47-39(5,6)7)36(34)43-20-17-40(8,9)18-21-43/h10-15,22,26,37H,16-21,23-25H2,1-9H3,(H,44,45)/t37-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
Envelope glycoprotein gp160


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM324162
PNG
(US10189816, Compound 155)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4ccc5OCCCc5c4)CCc3c2)c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C39H51N3O4/c1-25-33(35(42-18-15-39(6,7)16-19-42)34(26(2)40-25)36(37(43)44)46-38(3,4)5)30-11-12-31-24-41(17-14-28(31)22-30)23-27-10-13-32-29(21-27)9-8-20-45-32/h10-13,21-22,36H,8-9,14-20,23-24H2,1-7H3,(H,43,44)/t36-/m0/s1
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ViiV HEALTHCARE UK (NO. 5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10189816 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%