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Patent code US10189835

Compile Data Set for Download or QSAR
Found 22 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Capsid protein


(Hepatitis B virus genotype C subtype ayr (isolate ...)
BDBM324406
PNG
(US10189835, Compound 587)
Show SMILES CN(O)C(=O)c1n[nH]c2CCN(Cc12)C(=O)Nc1cccc(Cl)c1
Show InChI InChI=1S/C15H16ClN5O3/c1-20(24)14(22)13-11-8-21(6-5-12(11)18-19-13)15(23)17-10-4-2-3-9(16)7-10/h2-4,7,24H,5-6,8H2,1H3,(H,17,23)(H,18,19)
PDB

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n/an/an/an/a<1.00E+3n/an/an/an/a



NOVIRA THERAPEUTICS, INC.

US Patent


Assay Description
HBV replication inhibition by the compounds of this invention could be determined in cells infected or transfected with HBV, or cells with stably int...


US Patent US10189835 (2019)

More data for this
Ligand-Target Pair
Capsid protein


(Hepatitis B virus genotype C subtype ayr (isolate ...)
BDBM324427
PNG
(US10189835, Compound 937)
Show SMILES CN(C)N(C)C(=O)c1n[nH]c2CCN(Cc12)C(=O)Nc1cccc(Cl)c1
Show InChI InChI=1S/C17H21ClN6O2/c1-22(2)23(3)16(25)15-13-10-24(8-7-14(13)20-21-15)17(26)19-12-6-4-5-11(18)9-12/h4-6,9H,7-8,10H2,1-3H3,(H,19,26)(H,20,21)
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n/an/an/an/a<100n/an/an/an/a



NOVIRA THERAPEUTICS, INC.

US Patent


Assay Description
HBV replication inhibition by the compounds of this invention could be determined in cells infected or transfected with HBV, or cells with stably int...


US Patent US10189835 (2019)

More data for this
Ligand-Target Pair
Capsid protein


(Hepatitis B virus genotype C subtype ayr (isolate ...)
BDBM324422
PNG
(US10189835, Compound 698)
Show SMILES FC1CON(C1)C(=O)c1n[nH]c2CCN(Cc12)C(=O)Nc1cccc(Cl)c1
Show InChI InChI=1S/C17H17ClFN5O3/c18-10-2-1-3-12(6-10)20-17(26)23-5-4-14-13(8-23)15(22-21-14)16(25)24-7-11(19)9-27-24/h1-3,6,11H,4-5,7-9H2,(H,20,26)(H,21,22)
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n/an/an/an/a<100n/an/an/an/a



NOVIRA THERAPEUTICS, INC.

US Patent


Assay Description
HBV replication inhibition by the compounds of this invention could be determined in cells infected or transfected with HBV, or cells with stably int...


US Patent US10189835 (2019)

More data for this
Ligand-Target Pair
Capsid protein


(Hepatitis B virus genotype C subtype ayr (isolate ...)
BDBM324425
PNG
(US10189835, Compound 910)
Show SMILES CN(OC1CCOC1)C(=O)c1n[nH]c2CCN(Cc12)C(=O)Nc1cccc(Cl)c1
Show InChI InChI=1S/C19H22ClN5O4/c1-24(29-14-6-8-28-11-14)18(26)17-15-10-25(7-5-16(15)22-23-17)19(27)21-13-4-2-3-12(20)9-13/h2-4,9,14H,5-8,10-11H2,1H3,(H,21,27)(H,22,23)
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NOVIRA THERAPEUTICS, INC.

US Patent


Assay Description
HBV replication inhibition by the compounds of this invention could be determined in cells infected or transfected with HBV, or cells with stably int...


US Patent US10189835 (2019)

More data for this
Ligand-Target Pair
Capsid protein


(Hepatitis B virus genotype C subtype ayr (isolate ...)
BDBM324411
PNG
(US10189835, Compound 798)
Show SMILES CC(C)CON(C)C(=O)c1n[nH]c2CCN(Cc12)C(=O)Nc1cccc(Cl)c1
Show InChI InChI=1S/C19H24ClN5O3/c1-12(2)11-28-24(3)18(26)17-15-10-25(8-7-16(15)22-23-17)19(27)21-14-6-4-5-13(20)9-14/h4-6,9,12H,7-8,10-11H2,1-3H3,(H,21,27)(H,22,23)
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NOVIRA THERAPEUTICS, INC.

US Patent


Assay Description
HBV replication inhibition by the compounds of this invention could be determined in cells infected or transfected with HBV, or cells with stably int...


US Patent US10189835 (2019)

More data for this
Ligand-Target Pair
Capsid protein


(Hepatitis B virus genotype C subtype ayr (isolate ...)
BDBM324417
PNG
(US10189835, Compound 595)
Show SMILES CON(C(C)C)C(=O)c1n[nH]c2CCN(Cc12)C(=O)Nc1cccc(Cl)c1
Show InChI InChI=1S/C18H22ClN5O3/c1-11(2)24(27-3)17(25)16-14-10-23(8-7-15(14)21-22-16)18(26)20-13-6-4-5-12(19)9-13/h4-6,9,11H,7-8,10H2,1-3H3,(H,20,26)(H,21,22)
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NOVIRA THERAPEUTICS, INC.

US Patent


Assay Description
HBV replication inhibition by the compounds of this invention could be determined in cells infected or transfected with HBV, or cells with stably int...


US Patent US10189835 (2019)

More data for this
Ligand-Target Pair
Capsid protein


(Hepatitis B virus genotype C subtype ayr (isolate ...)
BDBM324405
PNG
(US10189835, Compound 561)
Show SMILES CCCC(=O)c1n[nH]c2CCN(Cc12)C(=O)Nc1cccc(Cl)c1
Show InChI InChI=1S/C17H19ClN4O2/c1-2-4-15(23)16-13-10-22(8-7-14(13)20-21-16)17(24)19-12-6-3-5-11(18)9-12/h3,5-6,9H,2,4,7-8,10H2,1H3,(H,19,24)(H,20,21)
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NOVIRA THERAPEUTICS, INC.

US Patent


Assay Description
HBV replication inhibition by the compounds of this invention could be determined in cells infected or transfected with HBV, or cells with stably int...


US Patent US10189835 (2019)

More data for this
Ligand-Target Pair
Capsid protein


(Hepatitis B virus genotype C subtype ayr (isolate ...)
BDBM324408
PNG
(US10189835, Compound 599)
Show SMILES CCON(C)C(=O)c1n[nH]c2CCN(Cc12)C(=O)Nc1cccc(Cl)c1
Show InChI InChI=1S/C17H20ClN5O3/c1-3-26-22(2)16(24)15-13-10-23(8-7-14(13)20-21-15)17(25)19-12-6-4-5-11(18)9-12/h4-6,9H,3,7-8,10H2,1-2H3,(H,19,25)(H,20,21)
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NOVIRA THERAPEUTICS, INC.

US Patent


Assay Description
HBV replication inhibition by the compounds of this invention could be determined in cells infected or transfected with HBV, or cells with stably int...


US Patent US10189835 (2019)

More data for this
Ligand-Target Pair
Capsid protein


(Hepatitis B virus genotype C subtype ayr (isolate ...)
BDBM324410
PNG
(US10189835, Compound 796)
Show SMILES CN(OCCO)C(=O)c1n[nH]c2CCN(Cc12)C(=O)Nc1cccc(Cl)c1
Show InChI InChI=1S/C17H20ClN5O4/c1-22(27-8-7-24)16(25)15-13-10-23(6-5-14(13)20-21-15)17(26)19-12-4-2-3-11(18)9-12/h2-4,9,24H,5-8,10H2,1H3,(H,19,26)(H,20,21)
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NOVIRA THERAPEUTICS, INC.

US Patent


Assay Description
HBV replication inhibition by the compounds of this invention could be determined in cells infected or transfected with HBV, or cells with stably int...


US Patent US10189835 (2019)

More data for this
Ligand-Target Pair
Capsid protein


(Hepatitis B virus genotype C subtype ayr (isolate ...)
BDBM324415
PNG
(US10189835, Compound 805)
Show SMILES CN(OC1CCC1)C(=O)c1n[nH]c2CCN(Cc12)C(=O)Nc1cccc(Cl)c1
Show InChI InChI=1S/C19H22ClN5O3/c1-24(28-14-6-3-7-14)18(26)17-15-11-25(9-8-16(15)22-23-17)19(27)21-13-5-2-4-12(20)10-13/h2,4-5,10,14H,3,6-9,11H2,1H3,(H,21,27)(H,22,23)
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n/an/an/an/a<100n/an/an/an/a



NOVIRA THERAPEUTICS, INC.

US Patent


Assay Description
HBV replication inhibition by the compounds of this invention could be determined in cells infected or transfected with HBV, or cells with stably int...


US Patent US10189835 (2019)

More data for this
Ligand-Target Pair
Capsid protein


(Hepatitis B virus genotype C subtype ayr (isolate ...)
BDBM324418
PNG
(US10189835, Compound 600)
Show SMILES CC(C)ON(C)C(=O)c1n[nH]c2CCN(Cc12)C(=O)Nc1cccc(Cl)c1
Show InChI InChI=1S/C18H22ClN5O3/c1-11(2)27-23(3)17(25)16-14-10-24(8-7-15(14)21-22-16)18(26)20-13-6-4-5-12(19)9-13/h4-6,9,11H,7-8,10H2,1-3H3,(H,20,26)(H,21,22)
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n/an/an/an/a<100n/an/an/an/a



NOVIRA THERAPEUTICS, INC.

US Patent


Assay Description
HBV replication inhibition by the compounds of this invention could be determined in cells infected or transfected with HBV, or cells with stably int...


US Patent US10189835 (2019)

More data for this
Ligand-Target Pair
Capsid protein


(Hepatitis B virus genotype C subtype ayr (isolate ...)
BDBM324419
PNG
(US10189835, Compound 695)
Show SMILES CCC(=O)c1n[nH]c2CCN(Cc12)C(=O)Nc1cccc(Cl)c1
Show InChI InChI=1S/C16H17ClN4O2/c1-2-14(22)15-12-9-21(7-6-13(12)19-20-15)16(23)18-11-5-3-4-10(17)8-11/h3-5,8H,2,6-7,9H2,1H3,(H,18,23)(H,19,20)
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n/an/an/an/a<500n/an/an/an/a



NOVIRA THERAPEUTICS, INC.

US Patent


Assay Description
HBV replication inhibition by the compounds of this invention could be determined in cells infected or transfected with HBV, or cells with stably int...


US Patent US10189835 (2019)

More data for this
Ligand-Target Pair
Capsid protein


(Hepatitis B virus genotype C subtype ayr (isolate ...)
BDBM324423
PNG
(US10189835, Compound 699)
Show SMILES Clc1cccc(NC(=O)N2CCc3[nH]nc(C(=O)N4CCCO4)c3C2)c1
Show InChI InChI=1S/C17H18ClN5O3/c18-11-3-1-4-12(9-11)19-17(25)22-7-5-14-13(10-22)15(21-20-14)16(24)23-6-2-8-26-23/h1,3-4,9H,2,5-8,10H2,(H,19,25)(H,20,21)
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NOVIRA THERAPEUTICS, INC.

US Patent


Assay Description
HBV replication inhibition by the compounds of this invention could be determined in cells infected or transfected with HBV, or cells with stably int...


US Patent US10189835 (2019)

More data for this
Ligand-Target Pair
Capsid protein


(Hepatitis B virus genotype C subtype ayr (isolate ...)
BDBM324403
PNG
(US10189835, Compound 434)
Show SMILES CON(C)C(=O)c1n[nH]c2CCN(Cc12)C(=O)Nc1cccc(Cl)c1
Show InChI InChI=1S/C16H18ClN5O3/c1-21(25-2)15(23)14-12-9-22(7-6-13(12)19-20-14)16(24)18-11-5-3-4-10(17)8-11/h3-5,8H,6-7,9H2,1-2H3,(H,18,24)(H,19,20)
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NOVIRA THERAPEUTICS, INC.

US Patent


Assay Description
HBV replication inhibition by the compounds of this invention could be determined in cells infected or transfected with HBV, or cells with stably int...


US Patent US10189835 (2019)

More data for this
Ligand-Target Pair
Capsid protein


(Hepatitis B virus genotype C subtype ayr (isolate ...)
BDBM324409
PNG
(US10189835, Compound 795)
Show SMILES CCCON(C)C(=O)c1n[nH]c2CCN(Cc12)C(=O)Nc1cccc(Cl)c1
Show InChI InChI=1S/C18H22ClN5O3/c1-3-9-27-23(2)17(25)16-14-11-24(8-7-15(14)21-22-16)18(26)20-13-6-4-5-12(19)10-13/h4-6,10H,3,7-9,11H2,1-2H3,(H,20,26)(H,21,22)
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NOVIRA THERAPEUTICS, INC.

US Patent


Assay Description
HBV replication inhibition by the compounds of this invention could be determined in cells infected or transfected with HBV, or cells with stably int...


US Patent US10189835 (2019)

More data for this
Ligand-Target Pair
Capsid protein


(Hepatitis B virus genotype C subtype ayr (isolate ...)
BDBM324416
PNG
(US10189835, Compound 594)
Show SMILES CCN(OC)C(=O)c1n[nH]c2CCN(Cc12)C(=O)Nc1cccc(Cl)c1
Show InChI InChI=1S/C17H20ClN5O3/c1-3-23(26-2)16(24)15-13-10-22(8-7-14(13)20-21-15)17(25)19-12-6-4-5-11(18)9-12/h4-6,9H,3,7-8,10H2,1-2H3,(H,19,25)(H,20,21)
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NOVIRA THERAPEUTICS, INC.

US Patent


Assay Description
HBV replication inhibition by the compounds of this invention could be determined in cells infected or transfected with HBV, or cells with stably int...


US Patent US10189835 (2019)

More data for this
Ligand-Target Pair
Capsid protein


(Hepatitis B virus genotype C subtype ayr (isolate ...)
BDBM324424
PNG
(US10189835, Compound 828)
Show SMILES CON(C)C(=O)c1n[nH]c2CC(C)N(Cc12)C(=O)Nc1cccc(Cl)c1
Show InChI InChI=1S/C17H20ClN5O3/c1-10-7-14-13(15(21-20-14)16(24)22(2)26-3)9-23(10)17(25)19-12-6-4-5-11(18)8-12/h4-6,8,10H,7,9H2,1-3H3,(H,19,25)(H,20,21)
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NOVIRA THERAPEUTICS, INC.

US Patent


Assay Description
HBV replication inhibition by the compounds of this invention could be determined in cells infected or transfected with HBV, or cells with stably int...


US Patent US10189835 (2019)

More data for this
Ligand-Target Pair
Capsid protein


(Hepatitis B virus genotype C subtype ayr (isolate ...)
BDBM324413
PNG
(US10189835, Compound 803)
Show SMILES CN(OCC1CC1)C(=O)c1n[nH]c2CCN(Cc12)C(=O)Nc1cccc(Cl)c1
Show InChI InChI=1S/C19H22ClN5O3/c1-24(28-11-12-5-6-12)18(26)17-15-10-25(8-7-16(15)22-23-17)19(27)21-14-4-2-3-13(20)9-14/h2-4,9,12H,5-8,10-11H2,1H3,(H,21,27)(H,22,23)
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n/an/an/an/a<500n/an/an/an/a



NOVIRA THERAPEUTICS, INC.

US Patent


Assay Description
HBV replication inhibition by the compounds of this invention could be determined in cells infected or transfected with HBV, or cells with stably int...


US Patent US10189835 (2019)

More data for this
Ligand-Target Pair
Capsid protein


(Hepatitis B virus genotype C subtype ayr (isolate ...)
BDBM324424
PNG
(US10189835, Compound 828)
Show SMILES CON(C)C(=O)c1n[nH]c2CC(C)N(Cc12)C(=O)Nc1cccc(Cl)c1
Show InChI InChI=1S/C17H20ClN5O3/c1-10-7-14-13(15(21-20-14)16(24)22(2)26-3)9-23(10)17(25)19-12-6-4-5-11(18)8-12/h4-6,8,10H,7,9H2,1-3H3,(H,19,25)(H,20,21)
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NOVIRA THERAPEUTICS, INC.

US Patent


Assay Description
HBV replication inhibition by the compounds of this invention could be determined in cells infected or transfected with HBV, or cells with stably int...


US Patent US10189835 (2019)

More data for this
Ligand-Target Pair
Capsid protein


(Hepatitis B virus genotype C subtype ayr (isolate ...)
BDBM324421
PNG
(US10189835, Compound 697)
Show SMILES OC1CON(C1)C(=O)c1n[nH]c2CCN(Cc12)C(=O)Nc1cccc(Cl)c1
Show InChI InChI=1S/C17H18ClN5O4/c18-10-2-1-3-11(6-10)19-17(26)22-5-4-14-13(8-22)15(21-20-14)16(25)23-7-12(24)9-27-23/h1-3,6,12,24H,4-5,7-9H2,(H,19,26)(H,20,21)
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n/an/an/an/a<1.00E+3n/an/an/an/a



NOVIRA THERAPEUTICS, INC.

US Patent


Assay Description
HBV replication inhibition by the compounds of this invention could be determined in cells infected or transfected with HBV, or cells with stably int...


US Patent US10189835 (2019)

More data for this
Ligand-Target Pair
Capsid protein


(Hepatitis B virus genotype C subtype ayr (isolate ...)
BDBM324426
PNG
(US10189835, Compound 912)
Show SMILES CN(OC1CN(C)C1)C(=O)c1n[nH]c2CCN(Cc12)C(=O)Nc1cccc(Cl)c1
Show InChI InChI=1S/C19H23ClN6O3/c1-24-9-14(10-24)29-25(2)18(27)17-15-11-26(7-6-16(15)22-23-17)19(28)21-13-5-3-4-12(20)8-13/h3-5,8,14H,6-7,9-11H2,1-2H3,(H,21,28)(H,22,23)
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n/an/an/an/a<500n/an/an/an/a



NOVIRA THERAPEUTICS, INC.

US Patent


Assay Description
HBV replication inhibition by the compounds of this invention could be determined in cells infected or transfected with HBV, or cells with stably int...


US Patent US10189835 (2019)

More data for this
Ligand-Target Pair
Capsid protein


(Hepatitis B virus genotype C subtype ayr (isolate ...)
BDBM324412
PNG
(US10189835, Compound 800)
Show SMILES COCCON(C)C(=O)c1n[nH]c2CCN(Cc12)C(=O)Nc1cccc(Cl)c1
Show InChI InChI=1S/C18H22ClN5O4/c1-23(28-9-8-27-2)17(25)16-14-11-24(7-6-15(14)21-22-16)18(26)20-13-5-3-4-12(19)10-13/h3-5,10H,6-9,11H2,1-2H3,(H,20,26)(H,21,22)
PDB

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n/an/an/an/a<500n/an/an/an/a



NOVIRA THERAPEUTICS, INC.

US Patent


Assay Description
HBV replication inhibition by the compounds of this invention could be determined in cells infected or transfected with HBV, or cells with stably int...


US Patent US10189835 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%