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Patent code US10189845

Compile Data Set for Download or QSAR

Found 867 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM325422
PNG
((S)-2-(4-(4-(1-(sec- butyl)-1H-pyrazol-4- yl)pyraz...)
Show SMILES CC[C@H](C)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C(CO)CO
Show InChI InChI=1S/C19H23N7O2/c1-3-13(2)24-9-15(7-21-24)19-18-4-5-20-26(18)10-17(23-19)14-6-22-25(8-14)16(11-27)12-28/h4-10,13,16,27-28H,3,11-12H2,1-2H3/t13-/m0/s1
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US10189845 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM325500
PNG
((1s,3s)-1-methyl-3-(4-(4-(1-(pentan-3-yl)-1H-pyraz...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C1C[C@@](C)(O)C1
Show InChI InChI=1S/C22H27N7O/c1-4-17(5-2)27-13-16(11-25-27)21-20-6-7-23-29(20)14-19(26-21)15-10-24-28(12-15)18-8-22(3,30)9-18/h6-7,10-14,17-18,30H,4-5,8-9H2,1-3H3/t18?,22-
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US10189845 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM325543
PNG
(US10189845, Example 205A | US10189845, Example 206...)
Show SMILES CCC(CC1CC1)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(C[C@@H](O)CO)c1
Show InChI InChI=1S/C22H27N7O2/c1-2-18(7-15-3-4-15)28-11-17(9-25-28)22-21-5-6-23-29(21)13-20(26-22)16-8-24-27(10-16)12-19(31)14-30/h5-6,8-11,13,15,18-19,30-31H,2-4,7,12,14H2,1H3/t18?,19-/m1/s1
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US10189845 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM325370
PNG
(6-(1-(1- (methylsulfonyl)piperidin- 4-yl)-1H-pyraz...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C23H30N8O2S/c1-4-19(5-2)29-15-18(13-26-29)23-22-6-9-24-31(22)16-21(27-23)17-12-25-30(14-17)20-7-10-28(11-8-20)34(3,32)33/h6,9,12-16,19-20H,4-5,7-8,10-11H2,1-3H3
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US10189845 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM325374
PNG
(2-amino-1-(4-(4-(4-(1-(pentan-3-yl)-1H-pyrazol-4-y...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C1CCN(CC1)C(=O)CN
Show InChI InChI=1S/C24H31N9O/c1-3-19(4-2)31-15-18(13-28-31)24-22-5-8-26-33(22)16-21(29-24)17-12-27-32(14-17)20-6-9-30(10-7-20)23(34)11-25/h5,8,12-16,19-20H,3-4,6-7,9-11,25H2,1-2H3
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US10189845 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM325385
PNG
(3-(4-(6-(1-methyl-1H- pyrazol-4- yl)pyrazolo[1,5- ...)
Show SMILES CCC(CCO)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(C)c1
Show InChI InChI=1S/C18H21N7O/c1-3-15(5-7-26)24-11-14(9-21-24)18-17-4-6-19-25(17)12-16(22-18)13-8-20-23(2)10-13/h4,6,8-12,15,26H,3,5,7H2,1-2H3
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US10189845 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM325514
PNG
(2-hydroxy-2-methyl-1-(3- (4-(4-(1-(pentan-3-yl)- 1...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C1CN(C1)C(=O)C(C)(C)O
Show InChI InChI=1S/C24H30N8O2/c1-5-18(6-2)30-12-17(10-27-30)22-21-7-8-25-32(21)15-20(28-22)16-9-26-31(11-16)19-13-29(14-19)23(33)24(3,4)34/h7-12,15,18-19,34H,5-6,13-14H2,1-4H3
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US10189845 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM325423
PNG
((R)-2-(4-(4-(1-(sec- butyl)-1H-pyrazol-4- yl)pyraz...)
Show SMILES CC[C@@H](C)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C(CO)CO
Show InChI InChI=1S/C19H23N7O2/c1-3-13(2)24-9-15(7-21-24)19-18-4-5-20-26(18)10-17(23-19)14-6-22-25(8-14)16(11-27)12-28/h4-10,13,16,27-28H,3,11-12H2,1-2H3/t13-/m1/s1
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US10189845 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM325455
PNG
(2-methyl-1-(4-(4-(1-(pentan-3-yl)-1H-pyrazol-4-yl)...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(CC(C)(C)O)c1
Show InChI InChI=1S/C21H27N7O/c1-5-17(6-2)27-12-16(10-24-27)20-19-7-8-22-28(19)13-18(25-20)15-9-23-26(11-15)14-21(3,4)29/h7-13,17,29H,5-6,14H2,1-4H3
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US10189845 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM325470
PNG
(US10189845, Example 132A | US10189845, Example 133...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)[C@@H]1C[C@H](O)[C@H](O)C1
Show InChI InChI=1S/C22H27N7O2/c1-3-16(4-2)27-12-15(10-25-27)22-19-5-6-23-29(19)13-18(26-22)14-9-24-28(11-14)17-7-20(30)21(31)8-17/h5-6,9-13,16-17,20-21,30-31H,3-4,7-8H2,1-2H3/t17-,20+,21-
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US10189845 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM325369
PNG
(1-(4-(4-(4-(1-(pentan-3-yl)-1H-pyrazol-4-yl)pyrazo...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C1CCN(CC1)C(C)=O
Show InChI InChI=1S/C24H30N8O/c1-4-20(5-2)30-15-19(13-27-30)24-23-6-9-25-32(23)16-22(28-24)18-12-26-31(14-18)21-7-10-29(11-8-21)17(3)33/h6,9,12-16,20-21H,4-5,7-8,10-11H2,1-3H3
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US10189845 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM325371
PNG
(2-methoxy-1-(4-(4-(4-(1- (pentan-3-yl)-1H-pyrazol-...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C1CCN(CC1)C(=O)COC
Show InChI InChI=1S/C25H32N8O2/c1-4-20(5-2)31-15-19(13-28-31)25-23-6-9-26-33(23)16-22(29-25)18-12-27-32(14-18)21-7-10-30(11-8-21)24(34)17-35-3/h6,9,12-16,20-21H,4-5,7-8,10-11,17H2,1-3H3
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US10189845 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM325513
PNG
((R)-2-hydroxy-1-(3-(4-(4-(1-(pentan-3-yl)-1H-pyraz...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C1CN(C1)C(=O)[C@@H](C)O
Show InChI InChI=1S/C23H28N8O2/c1-4-18(5-2)29-11-17(9-26-29)22-21-6-7-24-31(21)14-20(27-22)16-8-25-30(10-16)19-12-28(13-19)23(33)15(3)32/h6-11,14-15,18-19,32H,4-5,12-13H2,1-3H3/t15-/m1/s1
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US10189845 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM325351
PNG
(3-(4-(4-(1-(pentan-3-yl)-1H- pyrazol-4-yl)pyrazolo...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C1CS(=O)(=O)C1
Show InChI InChI=1S/C20H23N7O2S/c1-3-16(4-2)25-10-15(8-23-25)20-19-5-6-21-27(19)11-18(24-20)14-7-22-26(9-14)17-12-30(28,29)13-17/h5-11,16-17H,3-4,12-13H2,1-2H3
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US10189845 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM325372
PNG
(N-methyl-4-(4-(4-(1- (pentan-3-yl)-1H-pyrazol- 4-y...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C1CCN(CC1)C(=O)NC
Show InChI InChI=1S/C24H31N9O/c1-4-19(5-2)31-15-18(13-28-31)23-22-6-9-26-33(22)16-21(29-23)17-12-27-32(14-17)20-7-10-30(11-8-20)24(34)25-3/h6,9,12-16,19-20H,4-5,7-8,10-11H2,1-3H3,(H,25,34)
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US10189845 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM325374
PNG
(2-amino-1-(4-(4-(4-(1-(pentan-3-yl)-1H-pyrazol-4-y...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C1CCN(CC1)C(=O)CN
Show InChI InChI=1S/C24H31N9O/c1-3-19(4-2)31-15-18(13-28-31)24-22-5-8-26-33(22)16-21(29-24)17-12-27-32(14-17)20-6-9-30(10-7-20)23(34)11-25/h5,8,12-16,19-20H,3-4,6-7,9-11,25H2,1-2H3
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US10189845 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM325385
PNG
(3-(4-(6-(1-methyl-1H- pyrazol-4- yl)pyrazolo[1,5- ...)
Show SMILES CCC(CCO)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(C)c1
Show InChI InChI=1S/C18H21N7O/c1-3-15(5-7-26)24-11-14(9-21-24)18-17-4-6-19-25(17)12-16(22-18)13-8-20-23(2)10-13/h4,6,8-12,15,26H,3,5,7H2,1-2H3
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US10189845 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM325370
PNG
(6-(1-(1- (methylsulfonyl)piperidin- 4-yl)-1H-pyraz...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C23H30N8O2S/c1-4-19(5-2)29-15-18(13-26-29)23-22-6-9-24-31(22)16-21(27-23)17-12-25-30(14-17)20-7-10-28(11-8-20)34(3,32)33/h6,9,12-16,19-20H,4-5,7-8,10-11H2,1-3H3
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US10189845 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM325371
PNG
(2-methoxy-1-(4-(4-(4-(1- (pentan-3-yl)-1H-pyrazol-...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C1CCN(CC1)C(=O)COC
Show InChI InChI=1S/C25H32N8O2/c1-4-20(5-2)31-15-19(13-28-31)25-23-6-9-26-33(23)16-22(29-25)18-12-27-32(14-18)21-7-10-30(11-8-21)24(34)17-35-3/h6,9,12-16,20-21H,4-5,7-8,10-11,17H2,1-3H3
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US10189845 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM325375
PNG
(6-(1-(1-(methylsulfonyl)azetidin-3-yl)-1H-pyrazol-...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C1CN(C1)S(C)(=O)=O
Show InChI InChI=1S/C21H26N8O2S/c1-4-17(5-2)27-11-16(9-24-27)21-20-6-7-22-29(20)14-19(25-21)15-8-23-28(10-15)18-12-26(13-18)32(3,30)31/h6-11,14,17-18H,4-5,12-13H2,1-3H3
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US10189845 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM325456
PNG
(US10189845, Example 118 | trans-4-(4-(4-(1-(pentan...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C1CC[C@H](O)CC1
Show InChI InChI=1S/C23H29N7O/c1-3-18(4-2)28-14-17(12-26-28)23-22-9-10-24-30(22)15-21(27-23)16-11-25-29(13-16)19-5-7-20(31)8-6-19/h9-15,18-20,31H,3-8H2,1-2H3/t19?,20-
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US10189845 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM325499
PNG
(US10189845, Example 161 | trans-3-(4-(4-(1-(pentan...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)[C@H]1C[C@H](O)C1
Show InChI InChI=1S/C21H25N7O/c1-3-16(4-2)26-12-15(10-24-26)21-20-5-6-22-28(20)13-19(25-21)14-9-23-27(11-14)17-7-18(29)8-17/h5-6,9-13,16-18,29H,3-4,7-8H2,1-2H3/t17-,18-
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US10189845 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM325426
PNG
((R)-2-(4-(4-(1-(4- methylpentan-2-yl)-1H- pyrazol-...)
Show SMILES CC(C)C[C@@H](C)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C(CO)CO
Show InChI InChI=1S/C21H27N7O2/c1-14(2)6-15(3)26-10-17(8-23-26)21-20-4-5-22-28(20)11-19(25-21)16-7-24-27(9-16)18(12-29)13-30/h4-5,7-11,14-15,18,29-30H,6,12-13H2,1-3H3/t15-/m1/s1
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US10189845 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM325427
PNG
(US10189845, Example 89A)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)[C@@H](C)[C@H](O)CO
Show InChI InChI=1S/C21H27N7O2/c1-4-17(5-2)27-11-16(9-24-27)21-19-6-7-22-28(19)12-18(25-21)15-8-23-26(10-15)14(3)20(30)13-29/h6-12,14,17,20,29-30H,4-5,13H2,1-3H3/t14-,20+/m0/s1
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US10189845 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM325431
PNG
(US10189845, Example 93A | US10189845, Example 94B)
Show SMILES C[C@@H]1CCC[C@@H]1n1cc(cn1)-c1nc(cn2nccc12)C1=CN[N](C[C@@H](O)CO)=C1
Show InChI InChI=1S/C21H26N7O2/c1-14-3-2-4-19(14)27-10-16(8-24-27)21-20-5-6-22-28(20)12-18(25-21)15-7-23-26(9-15)11-17(30)13-29/h5-10,12,14,17,19,23,29-30H,2-4,11,13H2,1H3/t14-,17-,19+/m1/s1
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US10189845 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM325433
PNG
(US10189845, Example 95A | US10189845, Example 96B)
Show SMILES CC1(C)CCC[C@@H]1n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(C[C@@H](O)CO)c1
Show InChI InChI=1S/C22H27N7O2/c1-22(2)6-3-4-20(22)29-11-16(9-25-29)21-19-5-7-23-28(19)13-18(26-21)15-8-24-27(10-15)12-17(31)14-30/h5,7-11,13,17,20,30-31H,3-4,6,12,14H2,1-2H3/t17-,20+/m1/s1
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US10189845 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM325438
PNG
((R)-1-(methylamino)-3- (4-(4-(1-(pentan-3-yl)- 1H-...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(C[C@H](O)CNC)c1
Show InChI InChI=1S/C21H28N8O/c1-4-17(5-2)28-12-16(9-25-28)21-20-6-7-23-29(20)14-19(26-21)15-8-24-27(11-15)13-18(30)10-22-3/h6-9,11-12,14,17-18,22,30H,4-5,10,13H2,1-3H3/t18-/m1/s1
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US10189845 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM325447
PNG
((R)-1-(4-(4-(1-(pentan-3- yl)-1H-pyrazol-4- yl)pyr...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(C[C@@H](C)O)c1
Show InChI InChI=1S/C20H25N7O/c1-4-17(5-2)26-12-16(9-23-26)20-19-6-7-21-27(19)13-18(24-20)15-8-22-25(11-15)10-14(3)28/h6-9,11-14,17,28H,4-5,10H2,1-3H3/t14-/m1/s1
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US10189845 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM325455
PNG
(2-methyl-1-(4-(4-(1-(pentan-3-yl)-1H-pyrazol-4-yl)...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(CC(C)(C)O)c1
Show InChI InChI=1S/C21H27N7O/c1-5-17(6-2)27-12-16(10-24-27)20-19-7-8-22-28(19)13-18(25-20)15-9-23-26(11-15)14-21(3,4)29/h7-13,17,29H,5-6,14H2,1-4H3
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US10189845 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM325457
PNG
(US10189845, Example 119 | cis-3-(4-(4-(1-(pentan-3...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C1C[C@H](O)C1
Show InChI InChI=1S/C21H25N7O/c1-3-16(4-2)26-12-15(10-24-26)21-20-5-6-22-28(20)13-19(25-21)14-9-23-27(11-14)17-7-18(29)8-17/h5-6,9-13,16-18,29H,3-4,7-8H2,1-2H3/t17?,18-
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US10189845 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM325460
PNG
(((1s,3s)-3-((4-(4-(1-(pentan-3-yl)-1H-pyrazol-4-yl...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(CC2C[C@H](CO)C2)c1
Show InChI InChI=1S/C23H29N7O/c1-3-20(4-2)29-13-19(10-26-29)23-22-5-6-24-30(22)14-21(27-23)18-9-25-28(12-18)11-16-7-17(8-16)15-31/h5-6,9-10,12-14,16-17,20,31H,3-4,7-8,11,15H2,1-2H3/t16?,17-
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US10189845 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM325466
PNG
((R)-2-((4-(4-(1-(pentan-3- yl)-1H-pyrazol-4- yl)py...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(C[C@H]2CNCCO2)c1
Show InChI InChI=1S/C22H28N8O/c1-3-18(4-2)29-13-17(10-26-29)22-21-5-6-24-30(21)15-20(27-22)16-9-25-28(12-16)14-19-11-23-7-8-31-19/h5-6,9-10,12-13,15,18-19,23H,3-4,7-8,11,14H2,1-2H3/t19-/m1/s1
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US10189845 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM325466
PNG
((R)-2-((4-(4-(1-(pentan-3- yl)-1H-pyrazol-4- yl)py...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(C[C@H]2CNCCO2)c1
Show InChI InChI=1S/C22H28N8O/c1-3-18(4-2)29-13-17(10-26-29)22-21-5-6-24-30(21)15-20(27-22)16-9-25-28(12-16)14-19-11-23-7-8-31-19/h5-6,9-10,12-13,15,18-19,23H,3-4,7-8,11,14H2,1-2H3/t19-/m1/s1
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US10189845 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM325478
PNG
((R)-1-(2-(4-(4-(1-(pentan-3- yl)-1H-pyrazol-4- yl)...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(CCN2CC[C@@H](O)C2)c1
Show InChI InChI=1S/C23H30N8O/c1-3-19(4-2)30-14-18(12-26-30)23-22-5-7-24-31(22)16-21(27-23)17-11-25-29(13-17)10-9-28-8-6-20(32)15-28/h5,7,11-14,16,19-20,32H,3-4,6,8-10,15H2,1-2H3/t20-/m1/s1
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US10189845 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM325478
PNG
((R)-1-(2-(4-(4-(1-(pentan-3- yl)-1H-pyrazol-4- yl)...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(CCN2CC[C@@H](O)C2)c1
Show InChI InChI=1S/C23H30N8O/c1-3-19(4-2)30-14-18(12-26-30)23-22-5-7-24-31(22)16-21(27-23)17-11-25-29(13-17)10-9-28-8-6-20(32)15-28/h5,7,11-14,16,19-20,32H,3-4,6,8-10,15H2,1-2H3/t20-/m1/s1
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US10189845 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM325480
PNG
((S)-1-methyl-3-((2-(4-(4-(1- (pentan-3-yl)-1H-pyra...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(CCN[C@H]2CCN(C)C2=O)c1
Show InChI InChI=1S/C24H31N9O/c1-4-19(5-2)32-15-18(13-28-32)23-22-6-8-26-33(22)16-21(29-23)17-12-27-31(14-17)11-9-25-20-7-10-30(3)24(20)34/h6,8,12-16,19-20,25H,4-5,7,9-11H2,1-3H3/t20-/m0/s1
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US10189845 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM325481
PNG
((R)-1-methyl-3-((2-(4-(4-(1- (pentan-3-yl)-1H-pyra...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(CCN[C@@H]2CCN(C)C2=O)c1
Show InChI InChI=1S/C24H31N9O/c1-4-19(5-2)32-15-18(13-28-32)23-22-6-8-26-33(22)16-21(29-23)17-12-27-31(14-17)11-9-25-20-7-10-30(3)24(20)34/h6,8,12-16,19-20,25H,4-5,7,9-11H2,1-3H3/t20-/m1/s1
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US10189845 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM325492
PNG
(US10189845, Example 154B)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)[C@H]1CCC[C@@H]1O
Show InChI InChI=1S/C22H27N7O/c1-3-17(4-2)27-13-16(11-24-27)22-20-8-9-23-29(20)14-18(26-22)15-10-25-28(12-15)19-6-5-7-21(19)30/h8-14,17,19,21,30H,3-7H2,1-2H3/t19-,21-/m0/s1
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US10189845 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM325493
PNG
(US10189845, Example 155A)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)[C@@H](C)[C@H](C)O
Show InChI InChI=1S/C21H27N7O/c1-5-18(6-2)27-12-17(10-24-27)21-20-7-8-22-28(20)13-19(25-21)16-9-23-26(11-16)14(3)15(4)29/h7-15,18,29H,5-6H2,1-4H3/t14-,15-/m0/s1
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US10189845 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM325503
PNG
((trans-3-(4-(4-(1-(pentan-3-yl)-1H-pyrazol-4-yl)py...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C1C[C@H](CO)C1
Show InChI InChI=1S/C22H27N7O/c1-3-18(4-2)27-12-17(10-25-27)22-21-5-6-23-29(21)13-20(26-22)16-9-24-28(11-16)19-7-15(8-19)14-30/h5-6,9-13,15,18-19,30H,3-4,7-8,14H2,1-2H3/t15-,19?
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US10189845 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM325504
PNG
((cis-3-(4-(4-(1-(pentan- 3-yl)-1H-pyrazol-4- yl)py...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C1C[C@H](CO)C1
Show InChI InChI=1S/C22H27N7O/c1-3-18(4-2)27-12-17(10-25-27)22-21-5-6-23-29(21)13-20(26-22)16-9-24-28(11-16)19-7-15(8-19)14-30/h5-6,9-13,15,18-19,30H,3-4,7-8,14H2,1-2H3/t15-,19?
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US10189845 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM325507
PNG
((1r,3r)-N,N-dimethyl-3-(4- (4-(1-(pentan-3-yl)-1H-...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C1C[C@@H](C1)C(=O)N(C)C
Show InChI InChI=1S/C24H30N8O/c1-5-19(6-2)30-14-18(12-27-30)23-22-7-8-25-32(22)15-21(28-23)17-11-26-31(13-17)20-9-16(10-20)24(33)29(3)4/h7-8,11-16,19-20H,5-6,9-10H2,1-4H3/t16-,20?
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US10189845 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM325514
PNG
(2-hydroxy-2-methyl-1-(3- (4-(4-(1-(pentan-3-yl)- 1...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C1CN(C1)C(=O)C(C)(C)O
Show InChI InChI=1S/C24H30N8O2/c1-5-18(6-2)30-12-17(10-27-30)22-21-7-8-25-32(21)15-20(28-22)16-9-26-31(11-16)19-13-29(14-19)23(33)24(3,4)34/h7-12,15,18-19,34H,5-6,13-14H2,1-4H3
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US10189845 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM325518
PNG
(2-(3-hydroxyazetidin-1-yl)-1-(3-(4-(4-(1-(pentan-3...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C1CN(C1)C(=O)CN1CC(O)C1
Show InChI InChI=1S/C25H31N9O2/c1-3-19(4-2)32-10-18(8-28-32)25-23-5-6-26-34(23)15-22(29-25)17-7-27-33(9-17)20-11-31(12-20)24(36)16-30-13-21(35)14-30/h5-10,15,19-21,35H,3-4,11-14,16H2,1-2H3
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US10189845 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM325536
PNG
(US10189845, Example 198A | US10189845, Example 199...)
Show SMILES CCC(n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(C[C@@H](O)CO)c1)C(C)(F)F
Show InChI InChI=1S/C20H23F2N7O2/c1-3-18(20(2,21)22)29-9-14(7-25-29)19-17-4-5-23-28(17)11-16(26-19)13-6-24-27(8-13)10-15(31)12-30/h4-9,11,15,18,30-31H,3,10,12H2,1-2H3/t15-,18?/m1/s1
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US10189845 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM325542
PNG
(US10189845, Example 204A)
Show SMILES CCC([C@@H]1CC1(F)F)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(C[C@@H](O)CO)c1
Show InChI InChI=1S/C21H23F2N7O2/c1-2-18(16-5-21(16,22)23)29-9-14(7-26-29)20-19-3-4-24-30(19)11-17(27-20)13-6-25-28(8-13)10-15(32)12-31/h3-4,6-9,11,15-16,18,31-32H,2,5,10,12H2,1H3/t15-,16+,18?/m1/s1
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US10189845 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM325344
PNG
(1-morpholino-2-(4-(4-(1- (pentan-3-yl)-1H-pyrazol-...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(CC(=O)N2CCOCC2)c1
Show InChI InChI=1S/C23H28N8O2/c1-3-19(4-2)30-14-18(12-26-30)23-21-5-6-24-31(21)15-20(27-23)17-11-25-29(13-17)16-22(32)28-7-9-33-10-8-28/h5-6,11-15,19H,3-4,7-10,16H2,1-2H3
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US10189845 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM325345
PNG
(6-(1-(3- (methylsulfonyl)propyl)-1H- pyrazol-4-yl)...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(CCCS(C)(=O)=O)c1
Show InChI InChI=1S/C21H27N7O2S/c1-4-18(5-2)27-14-17(12-24-27)21-20-7-8-22-28(20)15-19(25-21)16-11-23-26(13-16)9-6-10-31(3,29)30/h7-8,11-15,18H,4-6,9-10H2,1-3H3
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US10189845 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM325347
PNG
(N-methyl-N-(2-(4-(4-(1- (pentan-3-yl)-1H-pyrazol-4...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(CCN(C)S(C)(=O)=O)c1
Show InChI InChI=1S/C21H28N8O2S/c1-5-18(6-2)28-14-17(12-24-28)21-20-7-8-22-29(20)15-19(25-21)16-11-23-27(13-16)10-9-26(3)32(4,30)31/h7-8,11-15,18H,5-6,9-10H2,1-4H3
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US10189845 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM325349
PNG
(4-((4-(4-(1-(pentan-3-yl)- 1H-pyrazol-4- yl)pyrazo...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(CC2CCS(=O)(=O)CC2)c1
Show InChI InChI=1S/C23H29N7O2S/c1-3-20(4-2)29-15-19(12-26-29)23-22-5-8-24-30(22)16-21(27-23)18-11-25-28(14-18)13-17-6-9-33(31,32)10-7-17/h5,8,11-12,14-17,20H,3-4,6-7,9-10,13H2,1-2H3
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US10189845 (2019)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%