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Patent code US10189859

Compile Data Set for Download or QSAR

Found 236 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM331848
PNG
(US10189859, Compound 118 | rrr)
Show SMILES C[C@H]1CN(C[C@@H](C)N1)c1nnc(c(N)n1)-c1cccc(Cl)c1Cl
Show InChI InChI=1S/C15H18Cl2N6/c1-8-6-23(7-9(2)19-8)15-20-14(18)13(21-22-15)10-4-3-5-11(16)12(10)17/h3-5,8-9,19H,6-7H2,1-2H3,(H2,18,20,22)/t8-,9+
PDB

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Nektar Therapeutics

US Patent


Assay Description
The potencies of the compounds provided herein to block specific Na+ channels was measured using automated patch clamp electrophysiologically of Nav1...


US Patent US10189859 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM331949
PNG
(US10189859, Compound 197 | methyl 2-(2-(2-((5-amin...)
Show SMILES COC(=O)COCCOCCNc1nnc(c(N)n1)-c1cccc(Cl)c1Cl
Show InChI InChI=1S/C16H19Cl2N5O4/c1-25-12(24)9-27-8-7-26-6-5-20-16-21-15(19)14(22-23-16)10-3-2-4-11(17)13(10)18/h2-4H,5-9H2,1H3,(H3,19,20,21,23)
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Nektar Therapeutics

US Patent


Assay Description
The potencies of the compounds provided herein to block specific Na+ channels was measured using automated patch clamp electrophysiologically of Nav1...


US Patent US10189859 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM331901
PNG
(6-(2,3-dichlorophenyl)-3-(4-(2-(trifluoromethoxy)e...)
Show SMILES Nc1nc(nnc1-c1cccc(Cl)c1Cl)N1CCN(CCOC(F)(F)F)CC1
Show InChI InChI=1S/C16H17Cl2F3N6O/c17-11-3-1-2-10(12(11)18)13-14(22)23-15(25-24-13)27-6-4-26(5-7-27)8-9-28-16(19,20)21/h1-3H,4-9H2,(H2,22,23,25)
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Nektar Therapeutics

US Patent


Assay Description
The potencies of the compounds provided herein to block specific Na+ channels was measured using automated patch clamp electrophysiologically of Nav1...


US Patent US10189859 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM331896
PNG
(6-(2,3-dichlorophenyl)-3-(4-(2,2,2-trifluoroethyl)...)
Show SMILES Nc1nc(nnc1-c1cccc(Cl)c1Cl)N1CCN(CC(F)(F)F)CC1
Show InChI InChI=1S/C15H15Cl2F3N6/c16-10-3-1-2-9(11(10)17)12-13(21)22-14(24-23-12)26-6-4-25(5-7-26)8-15(18,19)20/h1-3H,4-8H2,(H2,21,22,24)
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Nektar Therapeutics

US Patent


Assay Description
The potencies of the compounds provided herein to block specific Na+ channels was measured using automated patch clamp electrophysiologically of Nav1...


US Patent US10189859 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM331895
PNG
((S)-1-(4-(5-amino-6-(2,3-dichlorophenyl)-1,2,4-tri...)
Show SMILES COC[C@@H](O)CN1CCN(CC1)c1nnc(c(N)n1)-c1cccc(Cl)c1Cl
Show InChI InChI=1S/C17H22Cl2N6O2/c1-27-10-11(26)9-24-5-7-25(8-6-24)17-21-16(20)15(22-23-17)12-3-2-4-13(18)14(12)19/h2-4,11,26H,5-10H2,1H3,(H2,20,21,23)/t11-/m0/s1
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Nektar Therapeutics

US Patent


Assay Description
The potencies of the compounds provided herein to block specific Na+ channels was measured using automated patch clamp electrophysiologically of Nav1...


US Patent US10189859 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM323229
PNG
(US10189859, Compound 103 | rrr)
Show SMILES COCCOCCOCCN1CCN(CC1)c1nnc(c(N)n1)-c1cccc(Cl)c1Cl
Show InChI InChI=1S/C20H28Cl2N6O3/c1-29-11-12-31-14-13-30-10-9-27-5-7-28(8-6-27)20-24-19(23)18(25-26-20)15-3-2-4-16(21)17(15)22/h2-4H,5-14H2,1H3,(H2,23,24,26)
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Nektar Therapeutics

US Patent


Assay Description
The potencies of the compounds provided herein to block specific Na+ channels was measured using automated patch clamp electrophysiologically of Nav1...


US Patent US10189859 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM331895
PNG
((S)-1-(4-(5-amino-6-(2,3-dichlorophenyl)-1,2,4-tri...)
Show SMILES COC[C@@H](O)CN1CCN(CC1)c1nnc(c(N)n1)-c1cccc(Cl)c1Cl
Show InChI InChI=1S/C17H22Cl2N6O2/c1-27-10-11(26)9-24-5-7-25(8-6-24)17-21-16(20)15(22-23-17)12-3-2-4-13(18)14(12)19/h2-4,11,26H,5-10H2,1H3,(H2,20,21,23)/t11-/m0/s1
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Nektar Therapeutics

US Patent


Assay Description
The potencies of the compounds provided herein to block specific Na+ channels was measured using automated patch clamp electrophysiologically of Nav1...


US Patent US10189859 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM331908
PNG
((S)-3-((2-((5-amino-6-(2,3-dichlorophenyl)-1,2,4-t...)
Show SMILES CN(CCNc1nnc(c(N)n1)-c1cccc(Cl)c1Cl)C[C@H](O)C(F)(F)F
Show InChI InChI=1S/C15H17Cl2F3N6O/c1-26(7-10(27)15(18,19)20)6-5-22-14-23-13(21)12(24-25-14)8-3-2-4-9(16)11(8)17/h2-4,10,27H,5-7H2,1H3,(H3,21,22,23,25)/t10-/m0/s1
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Nektar Therapeutics

US Patent


Assay Description
The potencies of the compounds provided herein to block specific Na+ channels was measured using automated patch clamp electrophysiologically of Nav1...


US Patent US10189859 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM331850
PNG
(3-N-(3',5'-dimethylpiperazin-1-yl) 5'-fluoro lamot...)
Show SMILES C[C@H]1CN(C[C@@H](C)N1)c1nnc(c(N)n1)-c1cc(F)cc(Cl)c1Cl
Show InChI InChI=1S/C15H17Cl2FN6/c1-7-5-24(6-8(2)20-7)15-21-14(19)13(22-23-15)10-3-9(18)4-11(16)12(10)17/h3-4,7-8,20H,5-6H2,1-2H3,(H2,19,21,23)/t7-,8+
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Nektar Therapeutics

US Patent


Assay Description
The potencies of the compounds provided herein to block specific Na+ channels was measured using automated patch clamp electrophysiologically of Nav1...


US Patent US10189859 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM324401
PNG
(3-N-(4'-N-mPEG3-piperazinyl) 5-fluoro lamotrigine ...)
Show SMILES COCCOCCOCCOCC(=O)N1CCN(CC1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C18H34N2O7/c1-18(2,3)27-17(22)20-7-5-19(6-8-20)16(21)15-26-14-13-25-12-11-24-10-9-23-4/h5-15H2,1-4H3
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Nektar Therapeutics

US Patent


Assay Description
The potencies of the compounds provided herein to block specific Na+ channels was measured using automated patch clamp electrophysiologically of Nav1...


US Patent US10189859 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM331948
PNG
(US10189859, Compound 167 | rrr)
Show SMILES Nc1nc(NCCOCCOCCOC(F)(F)F)nnc1-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C16H18Cl2F3N5O3/c17-11-2-1-10(9-12(11)18)13-14(22)24-15(26-25-13)23-3-4-27-5-6-28-7-8-29-16(19,20)21/h1-2,9H,3-8H2,(H3,22,23,24,26)
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Nektar Therapeutics

US Patent


Assay Description
The potencies of the compounds provided herein to block specific Na+ channels was measured using automated patch clamp electrophysiologically of Nav1...


US Patent US10189859 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM331894
PNG
((R)-1-(4-(5-amino-6-(2,3-dichlorophenyl)-1,2,4-tri...)
Show SMILES COC[C@H](O)CN1CCN(CC1)c1nnc(c(N)n1)-c1cccc(Cl)c1Cl
Show InChI InChI=1S/C17H22Cl2N6O2/c1-27-10-11(26)9-24-5-7-25(8-6-24)17-21-16(20)15(22-23-17)12-3-2-4-13(18)14(12)19/h2-4,11,26H,5-10H2,1H3,(H2,20,21,23)/t11-/m1/s1
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Nektar Therapeutics

US Patent


Assay Description
The potencies of the compounds provided herein to block specific Na+ channels was measured using automated patch clamp electrophysiologically of Nav1...


US Patent US10189859 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM331948
PNG
(US10189859, Compound 167 | rrr)
Show SMILES Nc1nc(NCCOCCOCCOC(F)(F)F)nnc1-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C16H18Cl2F3N5O3/c17-11-2-1-10(9-12(11)18)13-14(22)24-15(26-25-13)23-3-4-27-5-6-28-7-8-29-16(19,20)21/h1-2,9H,3-8H2,(H3,22,23,24,26)
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Nektar Therapeutics

US Patent


Assay Description
The potencies of the compounds provided herein to block specific Na+ channels was measured using automated patch clamp electrophysiologically of Nav1...


US Patent US10189859 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM331907
PNG
(S)-3-((2-((5-amino-6-(2,3-dichlorophenyl)-1,2,4-tr...)
Show SMILES CN(CCNC[C@H](O)C(F)(F)F)c1nnc(c(N)n1)-c1cccc(Cl)c1Cl
Show InChI InChI=1S/C15H17Cl2F3N6O/c1-26(6-5-22-7-10(27)15(18,19)20)14-23-13(21)12(24-25-14)8-3-2-4-9(16)11(8)17/h2-4,10,22,27H,5-7H2,1H3,(H2,21,23,25)/t10-/m0/s1
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Nektar Therapeutics

US Patent


Assay Description
The potencies of the compounds provided herein to block specific Na+ channels was measured using automated patch clamp electrophysiologically of Nav1...


US Patent US10189859 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM331872
PNG
(US10189859, Compound 120 | rrr)
Show SMILES Nc1nc(nnc1-c1cccc(Cl)c1Cl)N1CCN(CC1)C1CCOCC1
Show InChI InChI=1S/C18H22Cl2N6O/c19-14-3-1-2-13(15(14)20)16-17(21)22-18(24-23-16)26-8-6-25(7-9-26)12-4-10-27-11-5-12/h1-3,12H,4-11H2,(H2,21,22,24)
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Nektar Therapeutics

US Patent


Assay Description
The potencies of the compounds provided herein to block specific Na+ channels was measured using automated patch clamp electrophysiologically of Nav1...


US Patent US10189859 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM331845
PNG
(3-N-(4-N-mPEG3-3,5-dimethylpiperazinyl) lamotrigin...)
Show SMILES COCCOCCOCCN1C(C)CN(CC1C)c1nnc(Cl)c(N)n1
Show InChI InChI=1S/C16H29ClN6O3/c1-12-10-22(16-19-15(18)14(17)20-21-16)11-13(2)23(12)4-5-25-8-9-26-7-6-24-3/h12-13H,4-11H2,1-3H3,(H2,18,19,21)
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Nektar Therapeutics

US Patent


Assay Description
The potencies of the compounds provided herein to block specific Na+ channels was measured using automated patch clamp electrophysiologically of Nav1...


US Patent US10189859 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM331954
PNG
(6-(2,3-dichlorophenyl)-N3-(2-((2-(2-methoxyethoxy)...)
Show SMILES COCCOCCN(C)CCN(C)c1nnc(c(N)n1)-c1cccc(Cl)c1Cl
Show InChI InChI=1S/C18H26Cl2N6O2/c1-25(9-10-28-12-11-27-3)7-8-26(2)18-22-17(21)16(23-24-18)13-5-4-6-14(19)15(13)20/h4-6H,7-12H2,1-3H3,(H2,21,22,24)
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Nektar Therapeutics

US Patent


Assay Description
The potencies of the compounds provided herein to block specific Na+ channels was measured using automated patch clamp electrophysiologically of Nav1...


US Patent US10189859 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM331948
PNG
(US10189859, Compound 167 | rrr)
Show SMILES Nc1nc(NCCOCCOCCOC(F)(F)F)nnc1-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C16H18Cl2F3N5O3/c17-11-2-1-10(9-12(11)18)13-14(22)24-15(26-25-13)23-3-4-27-5-6-28-7-8-29-16(19,20)21/h1-2,9H,3-8H2,(H3,22,23,24,26)
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Nektar Therapeutics

US Patent


Assay Description
The potencies of the compounds provided herein to block specific Na+ channels was measured using automated patch clamp electrophysiologically of Nav1...


US Patent US10189859 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM331920
PNG
(US10189859, Compound 73 | rrr)
Show SMILES CC(C)OC[C@H](O)CN1CCN(CC1)c1nnc(c(N)n1)-c1cccc(Cl)c1Cl
Show InChI InChI=1S/C19H26Cl2N6O2/c1-12(2)29-11-13(28)10-26-6-8-27(9-7-26)19-23-18(22)17(24-25-19)14-4-3-5-15(20)16(14)21/h3-5,12-13,28H,6-11H2,1-2H3,(H2,22,23,25)/t13-/m1/s1
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Nektar Therapeutics

US Patent


Assay Description
The potencies of the compounds provided herein to block specific Na+ channels was measured using automated patch clamp electrophysiologically of Nav1...


US Patent US10189859 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM331907
PNG
(S)-3-((2-((5-amino-6-(2,3-dichlorophenyl)-1,2,4-tr...)
Show SMILES CN(CCNC[C@H](O)C(F)(F)F)c1nnc(c(N)n1)-c1cccc(Cl)c1Cl
Show InChI InChI=1S/C15H17Cl2F3N6O/c1-26(6-5-22-7-10(27)15(18,19)20)14-23-13(21)12(24-25-14)8-3-2-4-9(16)11(8)17/h2-4,10,22,27H,5-7H2,1H3,(H2,21,23,25)/t10-/m0/s1
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Nektar Therapeutics

US Patent


Assay Description
The potencies of the compounds provided herein to block specific Na+ channels was measured using automated patch clamp electrophysiologically of Nav1...


US Patent US10189859 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM331960
PNG
(US10189859, Compound 203 | tert-butyl 2-(2-(4-(5-a...)
Show SMILES CC(C)(C)OC(=O)COCCN1CCN(CC1)c1nnc(c(N)n1)-c1cccc(Cl)c1Cl
Show InChI InChI=1S/C21H28Cl2N6O3/c1-21(2,3)32-16(30)13-31-12-11-28-7-9-29(10-8-28)20-25-19(24)18(26-27-20)14-5-4-6-15(22)17(14)23/h4-6H,7-13H2,1-3H3,(H2,24,25,27)
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Nektar Therapeutics

US Patent


Assay Description
The potencies of the compounds provided herein to block specific Na+ channels was measured using automated patch clamp electrophysiologically of Nav1...


US Patent US10189859 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM331939
PNG
(6-(2,3-dichlorophenyl)-N3-(3-(2-(2-methoxyethoxy)e...)
Show SMILES COCCOCCOCC(C)CNc1nnc(c(N)n1)-c1cccc(Cl)c1Cl
Show InChI InChI=1S/C18H25Cl2N5O3/c1-12(11-28-9-8-27-7-6-26-2)10-22-18-23-17(21)16(24-25-18)13-4-3-5-14(19)15(13)20/h3-5,12H,6-11H2,1-2H3,(H3,21,22,23,25)
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Nektar Therapeutics

US Patent


Assay Description
The potencies of the compounds provided herein to block specific Na+ channels was measured using automated patch clamp electrophysiologically of Nav1...


US Patent US10189859 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM331925
PNG
(US10189859, Compound 80 | rrr)
Show SMILES Nc1nc(nnc1-c1cccc(Cl)c1Cl)N1CCN(C[C@H](O)COCC2CCC2)CC1
Show InChI InChI=1S/C21H28Cl2N6O2/c22-17-6-2-5-16(18(17)23)19-20(24)25-21(27-26-19)29-9-7-28(8-10-29)11-15(30)13-31-12-14-3-1-4-14/h2,5-6,14-15,30H,1,3-4,7-13H2,(H2,24,25,27)/t15-/m0/s1
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Nektar Therapeutics

US Patent


Assay Description
The potencies of the compounds provided herein to block specific Na+ channels was measured using automated patch clamp electrophysiologically of Nav1...


US Patent US10189859 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM331926
PNG
((2S)-1-{4-[5-Amino-6-(2,3-dichlorophenyl)-1,2,4-tr...)
Show SMILES Nc1nc(nnc1-c1cccc(Cl)c1Cl)N1CCN(C[C@H](O)COCC2CC2)CC1
Show InChI InChI=1S/C20H26Cl2N6O2/c21-16-3-1-2-15(17(16)22)18-19(23)24-20(26-25-18)28-8-6-27(7-9-28)10-14(29)12-30-11-13-4-5-13/h1-3,13-14,29H,4-12H2,(H2,23,24,26)/t14-/m0/s1
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Nektar Therapeutics

US Patent


Assay Description
The potencies of the compounds provided herein to block specific Na+ channels was measured using automated patch clamp electrophysiologically of Nav1...


US Patent US10189859 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM331904
PNG
(US10189859, Compound 131 | rrr)
Show SMILES Nc1nc(nnc1-c1cccc(Cl)c1Cl)N1CCN2CCOC[C@@H]2C1
Show InChI InChI=1S/C16H18Cl2N6O/c17-12-3-1-2-11(13(12)18)14-15(19)20-16(22-21-14)24-5-4-23-6-7-25-9-10(23)8-24/h1-3,10H,4-9H2,(H2,19,20,22)/t10-/m0/s1
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Nektar Therapeutics

US Patent


Assay Description
The potencies of the compounds provided herein to block specific Na+ channels was measured using automated patch clamp electrophysiologically of Nav1...


US Patent US10189859 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM331929
PNG
((2S)-1-{4-[5-Amino-6-(2,3-dichlorophenyl)-1,2,4-tr...)
Show SMILES Nc1nc(nnc1-c1cccc(Cl)c1Cl)N1CCN(C[C@H](O)COC2CCC2)CC1
Show InChI InChI=1S/C20H26Cl2N6O2/c21-16-6-2-5-15(17(16)22)18-19(23)24-20(26-25-18)28-9-7-27(8-10-28)11-13(29)12-30-14-3-1-4-14/h2,5-6,13-14,29H,1,3-4,7-12H2,(H2,23,24,26)/t13-/m0/s1
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Nektar Therapeutics

US Patent


Assay Description
The potencies of the compounds provided herein to block specific Na+ channels was measured using automated patch clamp electrophysiologically of Nav1...


US Patent US10189859 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM331935
PNG
(6-(2,3-dichlorophenyl)-N3-(2-(2-(2-isopropoxyethox...)
Show SMILES CC(C)OCCOCCOCCNc1nnc(c(N)n1)-c1cccc(Cl)c1Cl
Show InChI InChI=1S/C18H25Cl2N5O3/c1-12(2)28-11-10-27-9-8-26-7-6-22-18-23-17(21)16(24-25-18)13-4-3-5-14(19)15(13)20/h3-5,12H,6-11H2,1-2H3,(H3,21,22,23,25)
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Nektar Therapeutics

US Patent


Assay Description
The potencies of the compounds provided herein to block specific Na+ channels was measured using automated patch clamp electrophysiologically of Nav1...


US Patent US10189859 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM331947
PNG
(6-(2,3-dichlorophenyl)-N3-(1-(2-(2-methoxyethoxy)e...)
Show SMILES COCCOCCOCC(C)Nc1nnc(c(N)n1)-c1cccc(Cl)c1Cl
Show InChI InChI=1S/C17H23Cl2N5O3/c1-11(10-27-9-8-26-7-6-25-2)21-17-22-16(20)15(23-24-17)12-4-3-5-13(18)14(12)19/h3-5,11H,6-10H2,1-2H3,(H3,20,21,22,24)
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Nektar Therapeutics

US Patent


Assay Description
The potencies of the compounds provided herein to block specific Na+ channels was measured using automated patch clamp electrophysiologically of Nav1...


US Patent US10189859 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM330403
PNG
(US10189859, Compound 1 | rrr)
Show SMILES COCC(COC)OCCNc1nnc(c(N)n1)-c1cccc(Cl)c1Cl
Show InChI InChI=1S/C16H21Cl2N5O3/c1-24-8-10(9-25-2)26-7-6-20-16-21-15(19)14(22-23-16)11-4-3-5-12(17)13(11)18/h3-5,10H,6-9H2,1-2H3,(H3,19,20,21,23)
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Nektar Therapeutics

US Patent


Assay Description
The potencies of the compounds provided herein to block specific Na+ channels was measured using automated patch clamp electrophysiologically of Nav1...


US Patent US10189859 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM331854
PNG
(US10189859, Compound 113 | rrr)
Show SMILES COCCOCCOCCN(C)C1CCN(CC1)c1nnc(c(N)n1)-c1cccc(Cl)c1Cl
Show InChI InChI=1S/C22H32Cl2N6O3/c1-29(10-11-32-14-15-33-13-12-31-2)16-6-8-30(9-7-16)22-26-21(25)20(27-28-22)17-4-3-5-18(23)19(17)24/h3-5,16H,6-15H2,1-2H3,(H2,25,26,28)
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Nektar Therapeutics

US Patent


Assay Description
The potencies of the compounds provided herein to block specific Na+ channels was measured using automated patch clamp electrophysiologically of Nav1...


US Patent US10189859 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM331895
PNG
((S)-1-(4-(5-amino-6-(2,3-dichlorophenyl)-1,2,4-tri...)
Show SMILES COC[C@@H](O)CN1CCN(CC1)c1nnc(c(N)n1)-c1cccc(Cl)c1Cl
Show InChI InChI=1S/C17H22Cl2N6O2/c1-27-10-11(26)9-24-5-7-25(8-6-24)17-21-16(20)15(22-23-17)12-3-2-4-13(18)14(12)19/h2-4,11,26H,5-10H2,1H3,(H2,20,21,23)/t11-/m0/s1
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Nektar Therapeutics

US Patent


Assay Description
The potencies of the compounds provided herein to block specific Na+ channels was measured using automated patch clamp electrophysiologically of Nav1...


US Patent US10189859 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM331928
PNG
((2S)-1-(6-(5-amino-6-(2,3-dichlorophenyl)-1,2,4-tr...)
Show SMILES COC[C@@H](O)CN1CCC11CCCN(C1)c1nnc(c(N)n1)-c1cccc(Cl)c1Cl
Show InChI InChI=1S/C20H26Cl2N6O2/c1-30-11-13(29)10-28-9-7-20(28)6-3-8-27(12-20)19-24-18(23)17(25-26-19)14-4-2-5-15(21)16(14)22/h2,4-5,13,29H,3,6-12H2,1H3,(H2,23,24,26)/t13-,20?/m0/s1
PDB

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Nektar Therapeutics

US Patent


Assay Description
The potencies of the compounds provided herein to block specific Na+ channels was measured using automated patch clamp electrophysiologically of Nav1...


US Patent US10189859 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM323229
PNG
(US10189859, Compound 103 | rrr)
Show SMILES COCCOCCOCCN1CCN(CC1)c1nnc(c(N)n1)-c1cccc(Cl)c1Cl
Show InChI InChI=1S/C20H28Cl2N6O3/c1-29-11-12-31-14-13-30-10-9-27-5-7-28(8-6-27)20-24-19(23)18(25-26-20)15-3-2-4-16(21)17(15)22/h2-4H,5-14H2,1H3,(H2,23,24,26)
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Nektar Therapeutics

US Patent


Assay Description
The potencies of the compounds provided herein to block specific Na+ channels was measured using automated patch clamp electrophysiologically of Nav1...


US Patent US10189859 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM331905
PNG
(2-(4-(5-amino-6-(2,3-dichlorophenyl)-1,2,4-triazin...)
Show SMILES CC(C)(CO)N1CCN(CC1)c1nnc(c(N)n1)-c1cccc(Cl)c1Cl
Show InChI InChI=1S/C17H22Cl2N6O/c1-17(2,10-26)25-8-6-24(7-9-25)16-21-15(20)14(22-23-16)11-4-3-5-12(18)13(11)19/h3-5,26H,6-10H2,1-2H3,(H2,20,21,23)
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Nektar Therapeutics

US Patent


Assay Description
The potencies of the compounds provided herein to block specific Na+ channels was measured using automated patch clamp electrophysiologically of Nav1...


US Patent US10189859 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM331895
PNG
((S)-1-(4-(5-amino-6-(2,3-dichlorophenyl)-1,2,4-tri...)
Show SMILES COC[C@@H](O)CN1CCN(CC1)c1nnc(c(N)n1)-c1cccc(Cl)c1Cl
Show InChI InChI=1S/C17H22Cl2N6O2/c1-27-10-11(26)9-24-5-7-25(8-6-24)17-21-16(20)15(22-23-17)12-3-2-4-13(18)14(12)19/h2-4,11,26H,5-10H2,1H3,(H2,20,21,23)/t11-/m0/s1
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Nektar Therapeutics

US Patent


Assay Description
The potencies of the compounds provided herein to block specific Na+ channels was measured using automated patch clamp electrophysiologically of Nav1...


US Patent US10189859 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM331910
PNG
(US10189859, Compound 133 | rrr)
Show SMILES Nc1nc(nnc1-c1cccc(Cl)c1Cl)N1CCC(O)(CC1)C(F)(F)F
Show InChI InChI=1S/C15H14Cl2F3N5O/c16-9-3-1-2-8(10(9)17)11-12(21)22-13(24-23-11)25-6-4-14(26,5-7-25)15(18,19)20/h1-3,26H,4-7H2,(H2,21,22,24)
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Nektar Therapeutics

US Patent


Assay Description
The potencies of the compounds provided herein to block specific Na+ channels was measured using automated patch clamp electrophysiologically of Nav1...


US Patent US10189859 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM330403
PNG
(US10189859, Compound 1 | rrr)
Show SMILES COCC(COC)OCCNc1nnc(c(N)n1)-c1cccc(Cl)c1Cl
Show InChI InChI=1S/C16H21Cl2N5O3/c1-24-8-10(9-25-2)26-7-6-20-16-21-15(19)14(22-23-16)11-4-3-5-12(17)13(11)18/h3-5,10H,6-9H2,1-2H3,(H3,19,20,21,23)
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Nektar Therapeutics

US Patent


Assay Description
The potencies of the compounds provided herein to block specific Na+ channels was measured using automated patch clamp electrophysiologically of Nav1...


US Patent US10189859 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM331919
PNG
(US10189859, Compound 55 | rrr)
Show SMILES CCOC[C@H](O)CN1CCN(CC1)c1nnc(c(N)n1)-c1cccc(Cl)c1Cl
Show InChI InChI=1S/C18H24Cl2N6O2/c1-2-28-11-12(27)10-25-6-8-26(9-7-25)18-22-17(21)16(23-24-18)13-4-3-5-14(19)15(13)20/h3-5,12,27H,2,6-11H2,1H3,(H2,21,22,24)/t12-/m1/s1
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Nektar Therapeutics

US Patent


Assay Description
The potencies of the compounds provided herein to block specific Na+ channels was measured using automated patch clamp electrophysiologically of Nav1...


US Patent US10189859 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM331954
PNG
(6-(2,3-dichlorophenyl)-N3-(2-((2-(2-methoxyethoxy)...)
Show SMILES COCCOCCN(C)CCN(C)c1nnc(c(N)n1)-c1cccc(Cl)c1Cl
Show InChI InChI=1S/C18H26Cl2N6O2/c1-25(9-10-28-12-11-27-3)7-8-26(2)18-22-17(21)16(23-24-18)13-5-4-6-14(19)15(13)20/h4-6H,7-12H2,1-3H3,(H2,21,22,24)
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Nektar Therapeutics

US Patent


Assay Description
The potencies of the compounds provided herein to block specific Na+ channels was measured using automated patch clamp electrophysiologically of Nav1...


US Patent US10189859 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM331900
PNG
(2-(4-(5-amino-6-(2,3-dichlorophenyl)-1,2,4-triazin...)
Show SMILES CC(CO)N1CCN(CC1)c1nnc(c(N)n1)-c1cccc(Cl)c1Cl
Show InChI InChI=1S/C16H20Cl2N6O/c1-10(9-25)23-5-7-24(8-6-23)16-20-15(19)14(21-22-16)11-3-2-4-12(17)13(11)18/h2-4,10,25H,5-9H2,1H3,(H2,19,20,22)
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Nektar Therapeutics

US Patent


Assay Description
The potencies of the compounds provided herein to block specific Na+ channels was measured using automated patch clamp electrophysiologically of Nav1...


US Patent US10189859 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM331925
PNG
(US10189859, Compound 80 | rrr)
Show SMILES Nc1nc(nnc1-c1cccc(Cl)c1Cl)N1CCN(C[C@H](O)COCC2CCC2)CC1
Show InChI InChI=1S/C21H28Cl2N6O2/c22-17-6-2-5-16(18(17)23)19-20(24)25-21(27-26-19)29-9-7-28(8-10-29)11-15(30)13-31-12-14-3-1-4-14/h2,5-6,14-15,30H,1,3-4,7-13H2,(H2,24,25,27)/t15-/m0/s1
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Nektar Therapeutics

US Patent


Assay Description
The potencies of the compounds provided herein to block specific Na+ channels was measured using automated patch clamp electrophysiologically of Nav1...


US Patent US10189859 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM331890
PNG
(US10189859, Compound 124 | rrr)
Show SMILES Nc1nc(nnc1-c1cccc(Cl)c1Cl)N1CCN[C@H](CO)C1
Show InChI InChI=1S/C14H16Cl2N6O/c15-10-3-1-2-9(11(10)16)12-13(17)19-14(21-20-12)22-5-4-18-8(6-22)7-23/h1-3,8,18,23H,4-7H2,(H2,17,19,21)/t8-/m0/s1
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Nektar Therapeutics

US Patent


Assay Description
The potencies of the compounds provided herein to block specific Na+ channels was measured using automated patch clamp electrophysiologically of Nav1...


US Patent US10189859 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM331891
PNG
(5-amino-3-[3-(s)-(hydroxymethyl)piperazin-1-yl] 5'...)
Show SMILES Nc1nc(nnc1-c1cc(F)cc(Cl)c1Cl)N1CCN[C@H](CO)C1
Show InChI InChI=1S/C14H15Cl2FN6O/c15-10-4-7(17)3-9(11(10)16)12-13(18)20-14(22-21-12)23-2-1-19-8(5-23)6-24/h3-4,8,19,24H,1-2,5-6H2,(H2,18,20,22)/t8-/m0/s1
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Nektar Therapeutics

US Patent


Assay Description
The potencies of the compounds provided herein to block specific Na+ channels was measured using automated patch clamp electrophysiologically of Nav1...


US Patent US10189859 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM331891
PNG
(5-amino-3-[3-(s)-(hydroxymethyl)piperazin-1-yl] 5'...)
Show SMILES Nc1nc(nnc1-c1cc(F)cc(Cl)c1Cl)N1CCN[C@H](CO)C1
Show InChI InChI=1S/C14H15Cl2FN6O/c15-10-4-7(17)3-9(11(10)16)12-13(18)20-14(22-21-12)23-2-1-19-8(5-23)6-24/h3-4,8,19,24H,1-2,5-6H2,(H2,18,20,22)/t8-/m0/s1
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UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/a 7.26E+4n/an/an/an/an/an/a



Nektar Therapeutics

US Patent


Assay Description
The potencies of the compounds provided herein to block specific Na+ channels was measured using automated patch clamp electrophysiologically of Nav1...


US Patent US10189859 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM331910
PNG
(US10189859, Compound 133 | rrr)
Show SMILES Nc1nc(nnc1-c1cccc(Cl)c1Cl)N1CCC(O)(CC1)C(F)(F)F
Show InChI InChI=1S/C15H14Cl2F3N5O/c16-9-3-1-2-8(10(9)17)11-12(21)22-13(24-23-11)25-6-4-14(26,5-7-25)15(18,19)20/h1-3,26H,4-7H2,(H2,21,22,24)
PDB

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UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 7.39E+4n/an/an/an/an/an/a



Nektar Therapeutics

US Patent


Assay Description
The potencies of the compounds provided herein to block specific Na+ channels was measured using automated patch clamp electrophysiologically of Nav1...


US Patent US10189859 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM331895
PNG
((S)-1-(4-(5-amino-6-(2,3-dichlorophenyl)-1,2,4-tri...)
Show SMILES COC[C@@H](O)CN1CCN(CC1)c1nnc(c(N)n1)-c1cccc(Cl)c1Cl
Show InChI InChI=1S/C17H22Cl2N6O2/c1-27-10-11(26)9-24-5-7-25(8-6-24)17-21-16(20)15(22-23-17)12-3-2-4-13(18)14(12)19/h2-4,11,26H,5-10H2,1H3,(H2,20,21,23)/t11-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 8.22E+4n/an/an/an/an/an/a



Nektar Therapeutics

US Patent


Assay Description
The potencies of the compounds provided herein to block specific Na+ channels was measured using automated patch clamp electrophysiologically of Nav1...


US Patent US10189859 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM331895
PNG
((S)-1-(4-(5-amino-6-(2,3-dichlorophenyl)-1,2,4-tri...)
Show SMILES COC[C@@H](O)CN1CCN(CC1)c1nnc(c(N)n1)-c1cccc(Cl)c1Cl
Show InChI InChI=1S/C17H22Cl2N6O2/c1-27-10-11(26)9-24-5-7-25(8-6-24)17-21-16(20)15(22-23-17)12-3-2-4-13(18)14(12)19/h2-4,11,26H,5-10H2,1H3,(H2,20,21,23)/t11-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 8.22E+4n/an/an/an/an/an/a



Nektar Therapeutics

US Patent


Assay Description
The potencies of the compounds provided herein to block specific Na+ channels was measured using automated patch clamp electrophysiologically of Nav1...


US Patent US10189859 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM330420
PNG
(3-N-piperazin-1-yl 5-fluoro lamotrigine | US101898...)
Show SMILES Nc1nc(nnc1-c1cc(F)cc(Cl)c1Cl)N1CCNCC1
Show InChI InChI=1S/C13H13Cl2FN6/c14-9-6-7(16)5-8(10(9)15)11-12(17)19-13(21-20-11)22-3-1-18-2-4-22/h5-6,18H,1-4H2,(H2,17,19,21)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
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GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/a 8.45E+4n/an/an/an/an/an/a



Nektar Therapeutics

US Patent


Assay Description
The potencies of the compounds provided herein to block specific Na+ channels was measured using automated patch clamp electrophysiologically of Nav1...


US Patent US10189859 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM331914
PNG
(US10189859, Compound 136 | rrr)
Show SMILES CC(C)(C)OCC(O)CN1CCN(C[C@H]1CO)c1nnc(c(N)n1)-c1cccc(Cl)c1Cl
Show InChI InChI=1S/C21H30Cl2N6O3/c1-21(2,3)32-12-14(31)10-28-7-8-29(9-13(28)11-30)20-25-19(24)18(26-27-20)15-5-4-6-16(22)17(15)23/h4-6,13-14,30-31H,7-12H2,1-3H3,(H2,24,25,27)/t13-,14?/m0/s1
PDB

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UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 8.66E+4n/an/an/an/an/an/a



Nektar Therapeutics

US Patent


Assay Description
The potencies of the compounds provided herein to block specific Na+ channels was measured using automated patch clamp electrophysiologically of Nav1...


US Patent US10189859 (2019)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM331960
PNG
(US10189859, Compound 203 | tert-butyl 2-(2-(4-(5-a...)
Show SMILES CC(C)(C)OC(=O)COCCN1CCN(CC1)c1nnc(c(N)n1)-c1cccc(Cl)c1Cl
Show InChI InChI=1S/C21H28Cl2N6O3/c1-21(2,3)32-16(30)13-31-12-11-28-7-9-29(10-8-28)20-25-19(24)18(26-27-20)14-5-4-6-15(22)17(14)23/h4-6H,7-13H2,1-3H3,(H2,24,25,27)
PDB

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UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 8.79E+4n/an/an/an/an/an/a



Nektar Therapeutics

US Patent


Assay Description
The potencies of the compounds provided herein to block specific Na+ channels was measured using automated patch clamp electrophysiologically of Nav1...


US Patent US10189859 (2019)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%