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Patent code US10195186

Compile Data Set for Download or QSAR
Found 101 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Neurotensin receptor 3


(Homo sapiens)
BDBM159226
PNG
(US10195186, Example 46 | US9682967, 44)
Show SMILES Cc1nccc(NC(=O)c2ccc(cc2C(O)=O)C(F)(F)F)n1
Show InChI InChI=1S/C14H10F3N3O3/c1-7-18-5-4-11(19-7)20-12(21)9-3-2-8(14(15,16)17)6-10(9)13(22)23/h2-6H,1H3,(H,22,23)(H,18,19,20,21)
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84n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM50445042
PNG
(CHEMBL3098767 | US10195186, Example 7 | US9682967,...)
Show SMILES Cc1ccc(NC(=O)c2ccc(cc2C(O)=O)C(F)(F)F)nc1C
Show InChI InChI=1S/C16H13F3N2O3/c1-8-3-6-13(20-9(8)2)21-14(22)11-5-4-10(16(17,18)19)7-12(11)15(23)24/h3-7H,1-2H3,(H,23,24)(H,20,21,22)
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162n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM50445055
PNG
(CHEMBL3098744 | US10195186, Example 45 | US9682967...)
Show SMILES CC(C)c1ccc(C(=O)Nc2cccc(C)n2)c(c1)C(O)=O
Show InChI InChI=1S/C17H18N2O3/c1-10(2)12-7-8-13(14(9-12)17(21)22)16(20)19-15-6-4-5-11(3)18-15/h4-10H,1-3H3,(H,21,22)(H,18,19,20)
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190n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Sortilin


(Mouse)
BDBM50445054
PNG
(CHEMBL3098745 | US10195186, Example 1 | US9682967,...)
Show SMILES Cc1cccc(NC(=O)c2ccc(cc2C(O)=O)C(F)(F)F)n1
Show InChI InChI=1S/C15H11F3N2O3/c1-8-3-2-4-12(19-8)20-13(21)10-6-5-9(15(16,17)18)7-11(10)14(22)23/h2-7H,1H3,(H,22,23)(H,19,20,21)
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210n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 μl in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Neurotensin receptor 3


(Homo sapiens)
BDBM159140
PNG
(US10195186, Example 18 | US9682967, 18)
Show SMILES Cc1ncc(NC(=O)c2ccc(cc2C(O)=O)C(F)(F)F)nc1C
Show InChI InChI=1S/C15H12F3N3O3/c1-7-8(2)20-12(6-19-7)21-13(22)10-4-3-9(15(16,17)18)5-11(10)14(23)24/h3-6H,1-2H3,(H,23,24)(H,20,21,22)
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229n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM159213
PNG
(US10195186, Example 44 | US9682967, 42)
Show SMILES CC(=C)c1ccc(C(=O)Nc2cccc(C)n2)c(c1)C(O)=O
Show InChI InChI=1S/C17H16N2O3/c1-10(2)12-7-8-13(14(9-12)17(21)22)16(20)19-15-6-4-5-11(3)18-15/h4-9H,1H2,2-3H3,(H,21,22)(H,18,19,20)
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286n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM159139
PNG
(US10195186, Example 17 | US9682967, 17)
Show SMILES Cc1ccnc(NC(=O)c2ccc(cc2C(O)=O)C(F)(F)F)n1
Show InChI InChI=1S/C14H10F3N3O3/c1-7-4-5-18-13(19-7)20-11(21)9-3-2-8(14(15,16)17)6-10(9)12(22)23/h2-6H,1H3,(H,22,23)(H,18,19,20,21)
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343n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM159138
PNG
(US10195186, Example 16 | US9682967, 16)
Show SMILES OC(=O)c1cc(ccc1C(=O)Nc1ncc(cc1Cl)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C15H7ClF6N2O3/c16-10-4-7(15(20,21)22)5-23-11(10)24-12(25)8-2-1-6(14(17,18)19)3-9(8)13(26)27/h1-5H,(H,26,27)(H,23,24,25)
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343n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM50445054
PNG
(CHEMBL3098745 | US10195186, Example 1 | US9682967,...)
Show SMILES Cc1cccc(NC(=O)c2ccc(cc2C(O)=O)C(F)(F)F)n1
Show InChI InChI=1S/C15H11F3N2O3/c1-8-3-2-4-12(19-8)20-13(21)10-6-5-9(15(16,17)18)7-11(10)14(22)23/h2-7H,1H3,(H,22,23)(H,19,20,21)
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429n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Neurotensin receptor 3


(Homo sapiens)
BDBM159123
PNG
(US10195186, Example 11 | US9682967, 11)
Show SMILES Cc1ccc(NC(=O)c2cc(Cl)c(Cl)cc2C(O)=O)nc1C
Show InChI InChI=1S/C15H12Cl2N2O3/c1-7-3-4-13(18-8(7)2)19-14(20)9-5-11(16)12(17)6-10(9)15(21)22/h3-6H,1-2H3,(H,21,22)(H,18,19,20)
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457n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM159129
PNG
(US10195186, Example 13 | US9682967, 13)
Show SMILES Cc1nccc(NC(=O)c2cc(Cl)c(Cl)cc2C(O)=O)n1
Show InChI InChI=1S/C13H9Cl2N3O3/c1-6-16-3-2-11(17-6)18-12(19)7-4-9(14)10(15)5-8(7)13(20)21/h2-5H,1H3,(H,20,21)(H,16,17,18,19)
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457n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM159178
PNG
(US10195186, Example 34 | US9682967, 32)
Show SMILES Cc1ccc(NC(=O)c2ccc(Br)cc2C(O)=O)nn1
Show InChI InChI=1S/C13H10BrN3O3/c1-7-2-5-11(17-16-7)15-12(18)9-4-3-8(14)6-10(9)13(19)20/h2-6H,1H3,(H,19,20)(H,15,17,18)
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467n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM159154
PNG
(US10195186, Example 23 | US9682967, 23)
Show SMILES Cc1ccc(NC(=O)c2ccc(Br)cc2C(O)=O)nc1C
Show InChI InChI=1S/C15H13BrN2O3/c1-8-3-6-13(17-9(8)2)18-14(19)11-5-4-10(16)7-12(11)15(20)21/h3-7H,1-2H3,(H,20,21)(H,17,18,19)
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543n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM159272
PNG
(US10195186, Example 50 | US9682967, 48)
Show SMILES OC(=O)c1cc(c(cc1C(=O)Nc1ccc2CCCCc2n1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C19H14F6N2O3/c20-18(21,22)12-7-10(11(17(29)30)8-13(12)19(23,24)25)16(28)27-15-6-5-9-3-1-2-4-14(9)26-15/h5-8H,1-4H2,(H,29,30)(H,26,27,28)
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599n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM159273
PNG
(US10195186, Example 51 | US9682967, 49)
Show SMILES Cc1ccc(NC(=O)c2cc(c(cc2C(O)=O)C(F)(F)F)C(F)(F)F)nc1C
Show InChI InChI=1S/C17H12F6N2O3/c1-7-3-4-13(24-8(7)2)25-14(26)9-5-11(16(18,19)20)12(17(21,22)23)6-10(9)15(27)28/h3-6H,1-2H3,(H,27,28)(H,24,25,26)
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614n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM159121
PNG
(US10195186, Example 9 | US9682967, 9)
Show SMILES Cc1cc(NC(=O)c2ccc(cc2C(O)=O)C(F)(F)F)ccn1
Show InChI InChI=1S/C15H11F3N2O3/c1-8-6-10(4-5-19-8)20-13(21)11-3-2-9(15(16,17)18)7-12(11)14(22)23/h2-7H,1H3,(H,22,23)(H,19,20,21)
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667n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM50445044
PNG
(CHEMBL3098765 | US10195186, Example 36 | US9682967...)
Show SMILES Cc1nccc(NC(=O)c2ccc(Br)cc2C(O)=O)n1
Show InChI InChI=1S/C13H10BrN3O3/c1-7-15-5-4-11(16-7)17-12(18)9-3-2-8(14)6-10(9)13(19)20/h2-6H,1H3,(H,19,20)(H,15,16,17,18)
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714n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM50445041
PNG
(CHEMBL3098768 | US10195186, Example 48 | US9682967...)
Show SMILES OC(=O)c1cc(ccc1C(=O)Nc1ccc2CCCCc2n1)C(F)(F)F
Show InChI InChI=1S/C18H15F3N2O3/c19-18(20,21)11-6-7-12(13(9-11)17(25)26)16(24)23-15-8-5-10-3-1-2-4-14(10)22-15/h5-9H,1-4H2,(H,25,26)(H,22,23,24)
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721n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM159271
PNG
(US10195186, Example 49 | US9682967, 47)
Show SMILES Cc1cccc(NC(=O)c2cc(c(cc2C(O)=O)C(F)(F)F)C(F)(F)F)n1
Show InChI InChI=1S/C16H10F6N2O3/c1-7-3-2-4-12(23-7)24-13(25)8-5-10(15(17,18)19)11(16(20,21)22)6-9(8)14(26)27/h2-6H,1H3,(H,26,27)(H,23,24,25)
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734n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM50445051
PNG
(CHEMBL3098752 | US10195186, Example 5 | US9682967,...)
Show SMILES Cc1cccc(NC(=O)c2cc(Cl)c(Cl)cc2C(O)=O)n1
Show InChI InChI=1S/C14H10Cl2N2O3/c1-7-3-2-4-12(17-7)18-13(19)8-5-10(15)11(16)6-9(8)14(20)21/h2-6H,1H3,(H,20,21)(H,17,18,19)
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790n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM332002
PNG
(5-Bromo-N-(6-methyl-pyridin-3-yl)-phthalamic acid ...)
Show SMILES Cc1ccc(NC(=O)c2ccc(Br)cc2C(O)=O)cn1
Show InChI InChI=1S/C14H11BrN2O3/c1-8-2-4-10(7-16-8)17-13(18)11-5-3-9(15)6-12(11)14(19)20/h2-7H,1H3,(H,17,18)(H,19,20)
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924n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM159146
PNG
(US10195186, Example 20 | US9682967, 20)
Show SMILES OC(=O)c1cc(Br)ccc1C(=O)Nc1ccc(Cl)cn1
Show InChI InChI=1S/C13H8BrClN2O3/c14-7-1-3-9(10(5-7)13(19)20)12(18)17-11-4-2-8(15)6-16-11/h1-6H,(H,19,20)(H,16,17,18)
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943n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM159117
PNG
(US10195186, Example 8 | US9682967, 8)
Show SMILES Cc1ccnc(NC(=O)c2ccc(cc2C(O)=O)C(F)(F)F)c1
Show InChI InChI=1S/C15H11F3N2O3/c1-8-4-5-19-12(6-8)20-13(21)10-3-2-9(15(16,17)18)7-11(10)14(22)23/h2-7H,1H3,(H,22,23)(H,19,20,21)
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952n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM159210
PNG
(US10195186, Example 43 | US9682967, 41)
Show SMILES CCCc1ccc(C(=O)Nc2cccc(C)n2)c(c1)C(O)=O
Show InChI InChI=1S/C17H18N2O3/c1-3-5-12-8-9-13(14(10-12)17(21)22)16(20)19-15-7-4-6-11(2)18-15/h4,6-10H,3,5H2,1-2H3,(H,21,22)(H,18,19,20)
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1.05E+3n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM50445058
PNG
(CHEMBL3098741 | US10195186, Example 2 | US9682967,...)
Show SMILES Cc1cccc(NC(=O)c2ccc(Br)cc2C(O)=O)n1
Show InChI InChI=1S/C14H11BrN2O3/c1-8-3-2-4-12(16-8)17-13(18)10-6-5-9(15)7-11(10)14(19)20/h2-7H,1H3,(H,19,20)(H,16,17,18)
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1.14E+3n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM159232
PNG
(US10195186, Example 47 | US9682967, 45)
Show SMILES Cc1cnc(NC(=O)c2ccc(cc2C(O)=O)C(F)(F)F)nc1C
Show InChI InChI=1S/C15H12F3N3O3/c1-7-6-19-14(20-8(7)2)21-12(22)10-4-3-9(15(16,17)18)5-11(10)13(23)24/h3-6H,1-2H3,(H,23,24)(H,19,20,21,22)
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1.14E+3n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM159188
PNG
(US10195186, Example 37 | US9682967, 35)
Show SMILES Cc1cc(NC(=O)c2ccc(Br)cc2C(O)=O)ncn1
Show InChI InChI=1S/C13H10BrN3O3/c1-7-4-11(16-6-15-7)17-12(18)9-3-2-8(14)5-10(9)13(19)20/h2-6H,1H3,(H,19,20)(H,15,16,17,18)
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1.24E+3n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM159166
PNG
(US10195186, Example 29 | US9682967, 28)
Show SMILES Cc1csc(NC(=O)c2ccc(Br)cc2C(O)=O)n1
Show InChI InChI=1S/C12H9BrN2O3S/c1-6-5-19-12(14-6)15-10(16)8-3-2-7(13)4-9(8)11(17)18/h2-5H,1H3,(H,17,18)(H,14,15,16)
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1.24E+3n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM50445057
PNG
(CHEMBL3098742 | US10195186, Example 4 | US9682967,...)
Show SMILES Cc1cccc(NC(=O)c2ccc(Cl)cc2C(O)=O)n1
Show InChI InChI=1S/C14H11ClN2O3/c1-8-3-2-4-12(16-8)17-13(18)10-6-5-9(15)7-11(10)14(19)20/h2-7H,1H3,(H,19,20)(H,16,17,18)
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1.33E+3n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM159189
PNG
(US10195186, Example 38 | US9682967, 36)
Show SMILES COc1cc(NC(=O)c2ccc(cc2C(O)=O)C(F)(F)F)ccn1
Show InChI InChI=1S/C15H11F3N2O4/c1-24-12-7-9(4-5-19-12)20-13(21)10-3-2-8(15(16,17)18)6-11(10)14(22)23/h2-7H,1H3,(H,22,23)(H,19,20,21)
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1.52E+3n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM50445047
PNG
(CHEMBL3098760 | US10195186, Example 22 | US9682967...)
Show SMILES OC(=O)c1cc(Br)ccc1C(=O)Nc1cccc(Cl)n1
Show InChI InChI=1S/C13H8BrClN2O3/c14-7-4-5-8(9(6-7)13(19)20)12(18)17-11-3-1-2-10(15)16-11/h1-6H,(H,19,20)(H,16,17,18)
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1.52E+3n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM159143
PNG
(US10195186, Example 19 | US9682967, 19)
Show SMILES Cc1ccc(NC(=O)c2ccc(Br)cc2C(O)=O)nc1
Show InChI InChI=1S/C14H11BrN2O3/c1-8-2-5-12(16-7-8)17-13(18)10-4-3-9(15)6-11(10)14(19)20/h2-7H,1H3,(H,19,20)(H,16,17,18)
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1.62E+3n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM50445045
PNG
(CHEMBL3098764 | US10195186, Example 25 | US9682967...)
Show SMILES Cc1cc(NC(=O)c2ccc(Br)cc2C(O)=O)ccn1
Show InChI InChI=1S/C14H11BrN2O3/c1-8-6-10(4-5-16-8)17-13(18)11-3-2-9(15)7-12(11)14(19)20/h2-7H,1H3,(H,19,20)(H,16,17,18)
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1.71E+3n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM159126
PNG
(US10195186, Example 12 | US9682967, 12)
Show SMILES Cc1cc(NC(=O)c2cc(Cl)c(Cl)cc2C(O)=O)ccn1
Show InChI InChI=1S/C14H10Cl2N2O3/c1-7-4-8(2-3-17-7)18-13(19)9-5-11(15)12(16)6-10(9)14(20)21/h2-6H,1H3,(H,20,21)(H,17,18,19)
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1.71E+3n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM159181
PNG
(US10195186, Example 35 | US9682967, 33)
Show SMILES Cc1cc(C)nc(NC(=O)c2ccc(Br)cc2C(O)=O)c1
Show InChI InChI=1S/C15H13BrN2O3/c1-8-5-9(2)17-13(6-8)18-14(19)11-4-3-10(16)7-12(11)15(20)21/h3-7H,1-2H3,(H,20,21)(H,17,18,19)
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1.91E+3n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM159169
PNG
(US10195186, Example 30 | US9682967, 29)
Show SMILES OC(=O)c1cc(Br)ccc1C(=O)Nc1ccc2ccccc2n1
Show InChI InChI=1S/C17H11BrN2O3/c18-11-6-7-12(13(9-11)17(22)23)16(21)20-15-8-5-10-3-1-2-4-14(10)19-15/h1-9H,(H,22,23)(H,19,20,21)
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2.00E+3n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM159122
PNG
(US10195186, Example 10 | US9682967, 10)
Show SMILES Cc1ccnc(NC(=O)c2cc(Cl)c(Cl)cc2C(O)=O)c1
Show InChI InChI=1S/C14H10Cl2N2O3/c1-7-2-3-17-12(4-7)18-13(19)8-5-10(15)11(16)6-9(8)14(20)21/h2-6H,1H3,(H,20,21)(H,17,18,19)
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2.10E+3n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM50445046
PNG
(CHEMBL3098761 | US10195186, Example 24 | US9682967...)
Show SMILES Cc1ccnc(NC(=O)c2ccc(Br)cc2C(O)=O)c1
Show InChI InChI=1S/C14H11BrN2O3/c1-8-4-5-16-12(6-8)17-13(18)10-3-2-9(15)7-11(10)14(19)20/h2-7H,1H3,(H,19,20)(H,16,17,18)
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2.29E+3n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM159172
PNG
(US10195186, Example 32 | US9682967, 30)
Show SMILES OC(=O)c1cc(Br)ccc1C(=O)Nc1ccc(Cl)c(Cl)n1
Show InChI InChI=1S/C13H7BrCl2N2O3/c14-6-1-2-7(8(5-6)13(20)21)12(19)18-10-4-3-9(15)11(16)17-10/h1-5H,(H,20,21)(H,17,18,19)
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3.05E+3n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM50445050
PNG
(CHEMBL3098753 | US10195186, Example 15 | US9682967...)
Show SMILES Cc1cccc(NC(=O)c2cc(C)c(C)cc2C(O)=O)n1
Show InChI InChI=1S/C16H16N2O3/c1-9-7-12(13(16(20)21)8-10(9)2)15(19)18-14-6-4-5-11(3)17-14/h4-8H,1-3H3,(H,20,21)(H,17,18,19)
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3.24E+3n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM159202
PNG
(US10195186, Example 41 | US9682967, 39)
Show SMILES OC(=O)c1cc(ccc1C(=O)NCc1ccncc1)C(F)(F)F
Show InChI InChI=1S/C15H11F3N2O3/c16-15(17,18)10-1-2-11(12(7-10)14(22)23)13(21)20-8-9-3-5-19-6-4-9/h1-7H,8H2,(H,20,21)(H,22,23)
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3.43E+3n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM331997
PNG
(5-Bromo-N-(3-methyl-pyridin-2-yl)-phthalamic acid ...)
Show SMILES Cc1cccnc1NC(=O)c1ccc(Br)cc1C(O)=O
Show InChI InChI=1S/C14H11BrN2O3/c1-8-3-2-6-16-12(8)17-13(18)10-5-4-9(15)7-11(10)14(19)20/h2-7H,1H3,(H,19,20)(H,16,17,18)
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3.43E+3n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM50445048
PNG
(CHEMBL3098759 | US10195186, Example 21 | US9682967...)
Show SMILES OC(=O)c1cc(Br)ccc1C(=O)Nc1ccccn1
Show InChI InChI=1S/C13H9BrN2O3/c14-8-4-5-9(10(7-8)13(18)19)12(17)16-11-3-1-2-6-15-11/h1-7H,(H,18,19)(H,15,16,17)
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3.43E+3n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM159134
PNG
(US10195186, Example 14 | US9682967, 14)
Show SMILES Cc1cccc(NC(=O)c2ccc(Cl)c(F)c2C(O)=O)n1
Show InChI InChI=1S/C14H10ClFN2O3/c1-7-3-2-4-10(17-7)18-13(19)8-5-6-9(15)12(16)11(8)14(20)21/h2-6H,1H3,(H,20,21)(H,17,18,19)
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4.00E+3n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM159199
PNG
(US10195186, Example 40 | US9682967, 38)
Show SMILES OC(=O)c1cc(ccc1C(=O)NCc1ccccn1)C(F)(F)F
Show InChI InChI=1S/C15H11F3N2O3/c16-15(17,18)9-4-5-11(12(7-9)14(22)23)13(21)20-8-10-3-1-2-6-19-10/h1-7H,8H2,(H,20,21)(H,22,23)
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4.57E+3n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM159206
PNG
(US10195186, Example 42 | US9682967, 40)
Show SMILES OC(=O)c1cc(ccc1C(=O)NCc1cccnc1)C(F)(F)F
Show InChI InChI=1S/C15H11F3N2O3/c16-15(17,18)10-3-4-11(12(6-10)14(22)23)13(21)20-8-9-2-1-5-19-7-9/h1-7H,8H2,(H,20,21)(H,22,23)
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4.95E+3n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM159162
PNG
(US10195186, Example 26 | US9682967, 26)
Show SMILES OC(=O)c1cc(Br)ccc1C(=O)Nc1cccnc1
Show InChI InChI=1S/C13H9BrN2O3/c14-8-3-4-10(11(6-8)13(18)19)12(17)16-9-2-1-5-15-7-9/h1-7H,(H,16,17)(H,18,19)
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5.24E+3n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM50445056
PNG
(CHEMBL3098743 | US10195186, Example 3 | US9682967,...)
Show SMILES Cc1ccc(C(=O)Nc2cccc(C)n2)c(c1)C(O)=O
Show InChI InChI=1S/C15H14N2O3/c1-9-6-7-11(12(8-9)15(19)20)14(18)17-13-5-3-4-10(2)16-13/h3-8H,1-2H3,(H,19,20)(H,16,17,18)
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6.10E+3n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM50445043
PNG
(CHEMBL3098766 | US10195186, Example 39 | US9682967...)
Show SMILES COc1cccc(NC(=O)c2ccc(cc2C(O)=O)C(F)(F)F)n1
Show InChI InChI=1S/C15H11F3N2O4/c1-24-12-4-2-3-11(19-12)20-13(21)9-6-5-8(15(16,17)18)7-10(9)14(22)23/h2-7H,1H3,(H,22,23)(H,19,20,21)
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7.14E+3n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM159226
PNG
(US10195186, Example 46 | US9682967, 44)
Show SMILES Cc1nccc(NC(=O)c2ccc(cc2C(O)=O)C(F)(F)F)n1
Show InChI InChI=1S/C14H10F3N3O3/c1-7-18-5-4-11(19-7)20-12(21)9-3-2-8(14(15,16)17)6-10(9)13(22)23/h2-6H,1H3,(H,22,23)(H,18,19,20,21)
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n/an/a 88n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM50445042
PNG
(CHEMBL3098767 | US10195186, Example 7 | US9682967,...)
Show SMILES Cc1ccc(NC(=O)c2ccc(cc2C(O)=O)C(F)(F)F)nc1C
Show InChI InChI=1S/C16H13F3N2O3/c1-8-3-6-13(20-9(8)2)21-14(22)11-5-4-10(16(17,18)19)7-12(11)15(23)24/h3-7H,1-2H3,(H,23,24)(H,20,21,22)
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H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM50445055
PNG
(CHEMBL3098744 | US10195186, Example 45 | US9682967...)
Show SMILES CC(C)c1ccc(C(=O)Nc2cccc(C)n2)c(c1)C(O)=O
Show InChI InChI=1S/C17H18N2O3/c1-10(2)12-7-8-13(14(9-12)17(21)22)16(20)19-15-6-4-5-11(3)18-15/h4-10H,1-3H3,(H,21,22)(H,18,19,20)
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H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Sortilin


(Mouse)
BDBM50445054
PNG
(CHEMBL3098745 | US10195186, Example 1 | US9682967,...)
Show SMILES Cc1cccc(NC(=O)c2ccc(cc2C(O)=O)C(F)(F)F)n1
Show InChI InChI=1S/C15H11F3N2O3/c1-8-3-2-4-12(19-8)20-13(21)10-6-5-9(15(16,17)18)7-11(10)14(22)23/h2-7H,1H3,(H,22,23)(H,19,20,21)
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n/an/a 220n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 μl in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Neurotensin receptor 3


(Homo sapiens)
BDBM159140
PNG
(US10195186, Example 18 | US9682967, 18)
Show SMILES Cc1ncc(NC(=O)c2ccc(cc2C(O)=O)C(F)(F)F)nc1C
Show InChI InChI=1S/C15H12F3N3O3/c1-7-8(2)20-12(6-19-7)21-13(22)10-4-3-9(15(16,17)18)5-11(10)14(23)24/h3-6H,1-2H3,(H,23,24)(H,20,21,22)
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n/an/a 240n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM50445054
PNG
(CHEMBL3098745 | US10195186, Example 1 | US9682967,...)
Show SMILES Cc1cccc(NC(=O)c2ccc(cc2C(O)=O)C(F)(F)F)n1
Show InChI InChI=1S/C15H11F3N2O3/c1-8-3-2-4-12(19-8)20-13(21)10-6-5-9(15(16,17)18)7-11(10)14(22)23/h2-7H,1H3,(H,22,23)(H,19,20,21)
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n/an/a 260n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The pro Sortilin assay was performed in total volume of 20 μl in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Neurotensin receptor 3


(Homo sapiens)
BDBM159213
PNG
(US10195186, Example 44 | US9682967, 42)
Show SMILES CC(=C)c1ccc(C(=O)Nc2cccc(C)n2)c(c1)C(O)=O
Show InChI InChI=1S/C17H16N2O3/c1-10(2)12-7-8-13(14(9-12)17(21)22)16(20)19-15-6-4-5-11(3)18-15/h4-9H,1H2,2-3H3,(H,21,22)(H,18,19,20)
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n/an/a 300n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM159139
PNG
(US10195186, Example 17 | US9682967, 17)
Show SMILES Cc1ccnc(NC(=O)c2ccc(cc2C(O)=O)C(F)(F)F)n1
Show InChI InChI=1S/C14H10F3N3O3/c1-7-4-5-18-13(19-7)20-11(21)9-3-2-8(14(15,16)17)6-10(9)12(22)23/h2-6H,1H3,(H,22,23)(H,18,19,20,21)
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n/an/a 360n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM159138
PNG
(US10195186, Example 16 | US9682967, 16)
Show SMILES OC(=O)c1cc(ccc1C(=O)Nc1ncc(cc1Cl)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C15H7ClF6N2O3/c16-10-4-7(15(20,21)22)5-23-11(10)24-12(25)8-2-1-6(14(17,18)19)3-9(8)13(26)27/h1-5H,(H,26,27)(H,23,24,25)
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n/an/a 360n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM50445054
PNG
(CHEMBL3098745 | US10195186, Example 1 | US9682967,...)
Show SMILES Cc1cccc(NC(=O)c2ccc(cc2C(O)=O)C(F)(F)F)n1
Show InChI InChI=1S/C15H11F3N2O3/c1-8-3-2-4-12(19-8)20-13(21)10-6-5-9(15(16,17)18)7-11(10)14(22)23/h2-7H,1H3,(H,22,23)(H,19,20,21)
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n/an/a 450n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Neurotensin receptor 3


(Homo sapiens)
BDBM159123
PNG
(US10195186, Example 11 | US9682967, 11)
Show SMILES Cc1ccc(NC(=O)c2cc(Cl)c(Cl)cc2C(O)=O)nc1C
Show InChI InChI=1S/C15H12Cl2N2O3/c1-7-3-4-13(18-8(7)2)19-14(20)9-5-11(16)12(17)6-10(9)15(21)22/h3-6H,1-2H3,(H,21,22)(H,18,19,20)
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n/an/a 480n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM159129
PNG
(US10195186, Example 13 | US9682967, 13)
Show SMILES Cc1nccc(NC(=O)c2cc(Cl)c(Cl)cc2C(O)=O)n1
Show InChI InChI=1S/C13H9Cl2N3O3/c1-6-16-3-2-11(17-6)18-12(19)7-4-9(14)10(15)5-8(7)13(20)21/h2-5H,1H3,(H,20,21)(H,16,17,18,19)
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n/an/a 480n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM159178
PNG
(US10195186, Example 34 | US9682967, 32)
Show SMILES Cc1ccc(NC(=O)c2ccc(Br)cc2C(O)=O)nn1
Show InChI InChI=1S/C13H10BrN3O3/c1-7-2-5-11(17-16-7)15-12(18)9-4-3-8(14)6-10(9)13(19)20/h2-6H,1H3,(H,19,20)(H,15,17,18)
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n/an/a 490n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM159154
PNG
(US10195186, Example 23 | US9682967, 23)
Show SMILES Cc1ccc(NC(=O)c2ccc(Br)cc2C(O)=O)nc1C
Show InChI InChI=1S/C15H13BrN2O3/c1-8-3-6-13(17-9(8)2)18-14(19)11-5-4-10(16)7-12(11)15(20)21/h3-7H,1-2H3,(H,20,21)(H,17,18,19)
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n/an/a 570n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM159272
PNG
(US10195186, Example 50 | US9682967, 48)
Show SMILES OC(=O)c1cc(c(cc1C(=O)Nc1ccc2CCCCc2n1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C19H14F6N2O3/c20-18(21,22)12-7-10(11(17(29)30)8-13(12)19(23,24)25)16(28)27-15-6-5-9-3-1-2-4-14(9)26-15/h5-8H,1-4H2,(H,29,30)(H,26,27,28)
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n/an/a 620n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM159273
PNG
(US10195186, Example 51 | US9682967, 49)
Show SMILES Cc1ccc(NC(=O)c2cc(c(cc2C(O)=O)C(F)(F)F)C(F)(F)F)nc1C
Show InChI InChI=1S/C17H12F6N2O3/c1-7-3-4-13(24-8(7)2)25-14(26)9-5-11(16(18,19)20)12(17(21,22)23)6-10(9)15(27)28/h3-6H,1-2H3,(H,27,28)(H,24,25,26)
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n/an/a 640n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM159121
PNG
(US10195186, Example 9 | US9682967, 9)
Show SMILES Cc1cc(NC(=O)c2ccc(cc2C(O)=O)C(F)(F)F)ccn1
Show InChI InChI=1S/C15H11F3N2O3/c1-8-6-10(4-5-19-8)20-13(21)11-3-2-9(15(16,17)18)7-12(11)14(22)23/h2-7H,1H3,(H,22,23)(H,19,20,21)
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n/an/a 700n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM50445044
PNG
(CHEMBL3098765 | US10195186, Example 36 | US9682967...)
Show SMILES Cc1nccc(NC(=O)c2ccc(Br)cc2C(O)=O)n1
Show InChI InChI=1S/C13H10BrN3O3/c1-7-15-5-4-11(16-7)17-12(18)9-3-2-8(14)6-10(9)13(19)20/h2-6H,1H3,(H,19,20)(H,15,16,17,18)
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H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM159271
PNG
(US10195186, Example 49 | US9682967, 47)
Show SMILES Cc1cccc(NC(=O)c2cc(c(cc2C(O)=O)C(F)(F)F)C(F)(F)F)n1
Show InChI InChI=1S/C16H10F6N2O3/c1-7-3-2-4-12(23-7)24-13(25)8-5-10(15(17,18)19)11(16(20,21)22)6-9(8)14(26)27/h2-6H,1H3,(H,26,27)(H,23,24,25)
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H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM50445041
PNG
(CHEMBL3098768 | US10195186, Example 48 | US9682967...)
Show SMILES OC(=O)c1cc(ccc1C(=O)Nc1ccc2CCCCc2n1)C(F)(F)F
Show InChI InChI=1S/C18H15F3N2O3/c19-18(20,21)11-6-7-12(13(9-11)17(25)26)16(24)23-15-8-5-10-3-1-2-4-14(10)22-15/h5-9H,1-4H2,(H,25,26)(H,22,23,24)
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H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM50445051
PNG
(CHEMBL3098752 | US10195186, Example 5 | US9682967,...)
Show SMILES Cc1cccc(NC(=O)c2cc(Cl)c(Cl)cc2C(O)=O)n1
Show InChI InChI=1S/C14H10Cl2N2O3/c1-7-3-2-4-12(17-7)18-13(19)8-5-10(15)11(16)6-9(8)14(20)21/h2-6H,1H3,(H,20,21)(H,17,18,19)
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H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM332002
PNG
(5-Bromo-N-(6-methyl-pyridin-3-yl)-phthalamic acid ...)
Show SMILES Cc1ccc(NC(=O)c2ccc(Br)cc2C(O)=O)cn1
Show InChI InChI=1S/C14H11BrN2O3/c1-8-2-4-10(7-16-8)17-13(18)11-5-3-9(15)6-12(11)14(19)20/h2-7H,1H3,(H,17,18)(H,19,20)
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H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM159146
PNG
(US10195186, Example 20 | US9682967, 20)
Show SMILES OC(=O)c1cc(Br)ccc1C(=O)Nc1ccc(Cl)cn1
Show InChI InChI=1S/C13H8BrClN2O3/c14-7-1-3-9(10(5-7)13(19)20)12(18)17-11-4-2-8(15)6-16-11/h1-6H,(H,19,20)(H,16,17,18)
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H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM159117
PNG
(US10195186, Example 8 | US9682967, 8)
Show SMILES Cc1ccnc(NC(=O)c2ccc(cc2C(O)=O)C(F)(F)F)c1
Show InChI InChI=1S/C15H11F3N2O3/c1-8-4-5-19-12(6-8)20-13(21)10-3-2-9(15(16,17)18)7-11(10)14(22)23/h2-7H,1H3,(H,22,23)(H,19,20,21)
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H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM159210
PNG
(US10195186, Example 43 | US9682967, 41)
Show SMILES CCCc1ccc(C(=O)Nc2cccc(C)n2)c(c1)C(O)=O
Show InChI InChI=1S/C17H18N2O3/c1-3-5-12-8-9-13(14(10-12)17(21)22)16(20)19-15-7-4-6-11(2)18-15/h4,6-10H,3,5H2,1-2H3,(H,21,22)(H,18,19,20)
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H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM159232
PNG
(US10195186, Example 47 | US9682967, 45)
Show SMILES Cc1cnc(NC(=O)c2ccc(cc2C(O)=O)C(F)(F)F)nc1C
Show InChI InChI=1S/C15H12F3N3O3/c1-7-6-19-14(20-8(7)2)21-12(22)10-4-3-9(15(16,17)18)5-11(10)13(23)24/h3-6H,1-2H3,(H,23,24)(H,19,20,21,22)
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H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM50445058
PNG
(CHEMBL3098741 | US10195186, Example 2 | US9682967,...)
Show SMILES Cc1cccc(NC(=O)c2ccc(Br)cc2C(O)=O)n1
Show InChI InChI=1S/C14H11BrN2O3/c1-8-3-2-4-12(16-8)17-13(18)10-6-5-9(15)7-11(10)14(19)20/h2-7H,1H3,(H,19,20)(H,16,17,18)
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H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM159188
PNG
(US10195186, Example 37 | US9682967, 35)
Show SMILES Cc1cc(NC(=O)c2ccc(Br)cc2C(O)=O)ncn1
Show InChI InChI=1S/C13H10BrN3O3/c1-7-4-11(16-6-15-7)17-12(18)9-3-2-8(14)5-10(9)13(19)20/h2-6H,1H3,(H,19,20)(H,15,16,17,18)
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n/an/a 1.30E+3n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM159166
PNG
(US10195186, Example 29 | US9682967, 28)
Show SMILES Cc1csc(NC(=O)c2ccc(Br)cc2C(O)=O)n1
Show InChI InChI=1S/C12H9BrN2O3S/c1-6-5-19-12(14-6)15-10(16)8-3-2-7(13)4-9(8)11(17)18/h2-5H,1H3,(H,17,18)(H,14,15,16)
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n/an/a 1.30E+3n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM50445057
PNG
(CHEMBL3098742 | US10195186, Example 4 | US9682967,...)
Show SMILES Cc1cccc(NC(=O)c2ccc(Cl)cc2C(O)=O)n1
Show InChI InChI=1S/C14H11ClN2O3/c1-8-3-2-4-12(16-8)17-13(18)10-6-5-9(15)7-11(10)14(19)20/h2-7H,1H3,(H,19,20)(H,16,17,18)
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n/an/a 1.40E+3n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM50445047
PNG
(CHEMBL3098760 | US10195186, Example 22 | US9682967...)
Show SMILES OC(=O)c1cc(Br)ccc1C(=O)Nc1cccc(Cl)n1
Show InChI InChI=1S/C13H8BrClN2O3/c14-7-4-5-8(9(6-7)13(19)20)12(18)17-11-3-1-2-10(15)16-11/h1-6H,(H,19,20)(H,16,17,18)
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n/an/a 1.60E+3n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM159189
PNG
(US10195186, Example 38 | US9682967, 36)
Show SMILES COc1cc(NC(=O)c2ccc(cc2C(O)=O)C(F)(F)F)ccn1
Show InChI InChI=1S/C15H11F3N2O4/c1-24-12-7-9(4-5-19-12)20-13(21)10-3-2-8(15(16,17)18)6-11(10)14(22)23/h2-7H,1H3,(H,22,23)(H,19,20,21)
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H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM159143
PNG
(US10195186, Example 19 | US9682967, 19)
Show SMILES Cc1ccc(NC(=O)c2ccc(Br)cc2C(O)=O)nc1
Show InChI InChI=1S/C14H11BrN2O3/c1-8-2-5-12(16-7-8)17-13(18)10-4-3-9(15)6-11(10)14(19)20/h2-7H,1H3,(H,19,20)(H,16,17,18)
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n/an/a 1.70E+3n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM50445045
PNG
(CHEMBL3098764 | US10195186, Example 25 | US9682967...)
Show SMILES Cc1cc(NC(=O)c2ccc(Br)cc2C(O)=O)ccn1
Show InChI InChI=1S/C14H11BrN2O3/c1-8-6-10(4-5-16-8)17-13(18)11-3-2-9(15)7-12(11)14(19)20/h2-7H,1H3,(H,19,20)(H,16,17,18)
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n/an/a 1.80E+3n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM159126
PNG
(US10195186, Example 12 | US9682967, 12)
Show SMILES Cc1cc(NC(=O)c2cc(Cl)c(Cl)cc2C(O)=O)ccn1
Show InChI InChI=1S/C14H10Cl2N2O3/c1-7-4-8(2-3-17-7)18-13(19)9-5-11(15)12(16)6-10(9)14(20)21/h2-6H,1H3,(H,20,21)(H,17,18,19)
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n/an/a 1.80E+3n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM50445054
PNG
(CHEMBL3098745 | US10195186, Example 1 | US9682967,...)
Show SMILES Cc1cccc(NC(=O)c2ccc(cc2C(O)=O)C(F)(F)F)n1
Show InChI InChI=1S/C15H11F3N2O3/c1-8-3-2-4-12(19-8)20-13(21)10-6-5-9(15(16,17)18)7-11(10)14(22)23/h2-7H,1H3,(H,22,23)(H,19,20,21)
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n/an/a 1.80E+3n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The progranulin Sortilin assay was performed in total volume of 20 μl in 50 mM Phosphate buffer pH 7.0 assay buffer containing 0.1% BSA. Varying...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Neurotensin receptor 3


(Homo sapiens)
BDBM159181
PNG
(US10195186, Example 35 | US9682967, 33)
Show SMILES Cc1cc(C)nc(NC(=O)c2ccc(Br)cc2C(O)=O)c1
Show InChI InChI=1S/C15H13BrN2O3/c1-8-5-9(2)17-13(6-8)18-14(19)11-4-3-10(16)7-12(11)15(20)21/h3-7H,1-2H3,(H,20,21)(H,17,18,19)
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n/an/a 2.00E+3n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM159169
PNG
(US10195186, Example 30 | US9682967, 29)
Show SMILES OC(=O)c1cc(Br)ccc1C(=O)Nc1ccc2ccccc2n1
Show InChI InChI=1S/C17H11BrN2O3/c18-11-6-7-12(13(9-11)17(22)23)16(21)20-15-8-5-10-3-1-2-4-14(10)19-15/h1-9H,(H,22,23)(H,19,20,21)
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n/an/a 2.10E+3n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM159122
PNG
(US10195186, Example 10 | US9682967, 10)
Show SMILES Cc1ccnc(NC(=O)c2cc(Cl)c(Cl)cc2C(O)=O)c1
Show InChI InChI=1S/C14H10Cl2N2O3/c1-7-2-3-17-12(4-7)18-13(19)8-5-10(15)11(16)6-9(8)14(20)21/h2-6H,1H3,(H,20,21)(H,17,18,19)
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n/an/a 2.20E+3n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM50445046
PNG
(CHEMBL3098761 | US10195186, Example 24 | US9682967...)
Show SMILES Cc1ccnc(NC(=O)c2ccc(Br)cc2C(O)=O)c1
Show InChI InChI=1S/C14H11BrN2O3/c1-8-4-5-16-12(6-8)17-13(18)10-3-2-9(15)7-11(10)14(19)20/h2-7H,1H3,(H,19,20)(H,16,17,18)
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n/an/a 2.40E+3n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM159172
PNG
(US10195186, Example 32 | US9682967, 30)
Show SMILES OC(=O)c1cc(Br)ccc1C(=O)Nc1ccc(Cl)c(Cl)n1
Show InChI InChI=1S/C13H7BrCl2N2O3/c14-6-1-2-7(8(5-6)13(20)21)12(19)18-10-4-3-9(15)11(16)17-10/h1-5H,(H,20,21)(H,17,18,19)
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n/an/a 3.20E+3n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM50445050
PNG
(CHEMBL3098753 | US10195186, Example 15 | US9682967...)
Show SMILES Cc1cccc(NC(=O)c2cc(C)c(C)cc2C(O)=O)n1
Show InChI InChI=1S/C16H16N2O3/c1-9-7-12(13(16(20)21)8-10(9)2)15(19)18-14-6-4-5-11(3)17-14/h4-8H,1-3H3,(H,20,21)(H,17,18,19)
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n/an/a 3.40E+3n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM331997
PNG
(5-Bromo-N-(3-methyl-pyridin-2-yl)-phthalamic acid ...)
Show SMILES Cc1cccnc1NC(=O)c1ccc(Br)cc1C(O)=O
Show InChI InChI=1S/C14H11BrN2O3/c1-8-3-2-6-16-12(8)17-13(18)10-5-4-9(15)7-11(10)14(19)20/h2-7H,1H3,(H,19,20)(H,16,17,18)
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n/an/a 3.60E+3n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM50445048
PNG
(CHEMBL3098759 | US10195186, Example 21 | US9682967...)
Show SMILES OC(=O)c1cc(Br)ccc1C(=O)Nc1ccccn1
Show InChI InChI=1S/C13H9BrN2O3/c14-8-4-5-9(10(7-8)13(18)19)12(17)16-11-3-1-2-6-15-11/h1-7H,(H,18,19)(H,15,16,17)
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n/an/a 3.60E+3n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM159202
PNG
(US10195186, Example 41 | US9682967, 39)
Show SMILES OC(=O)c1cc(ccc1C(=O)NCc1ccncc1)C(F)(F)F
Show InChI InChI=1S/C15H11F3N2O3/c16-15(17,18)10-1-2-11(12(7-10)14(22)23)13(21)20-8-9-3-5-19-6-4-9/h1-7H,8H2,(H,20,21)(H,22,23)
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n/an/a 3.60E+3n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM331966
PNG
(5-Bromo-N-(3-methyl-4,5,6,7-tetrahydro-benzo [b]th...)
Show SMILES OC(=O)c1cc(Br)ccc1C(=O)Nc1sc2CCCCc2c1[N+]#[C-]
Show InChI InChI=1S/C17H13BrN2O3S/c1-19-14-11-4-2-3-5-13(11)24-16(14)20-15(21)10-7-6-9(18)8-12(10)17(22)23/h6-8H,2-5H2,(H,20,21)(H,22,23)
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n/an/a 4.00E+3n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM159134
PNG
(US10195186, Example 14 | US9682967, 14)
Show SMILES Cc1cccc(NC(=O)c2ccc(Cl)c(F)c2C(O)=O)n1
Show InChI InChI=1S/C14H10ClFN2O3/c1-7-3-2-4-10(17-7)18-13(19)8-5-6-9(15)12(16)11(8)14(20)21/h2-6H,1H3,(H,20,21)(H,17,18,19)
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n/an/a 4.20E+3n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM159199
PNG
(US10195186, Example 40 | US9682967, 38)
Show SMILES OC(=O)c1cc(ccc1C(=O)NCc1ccccn1)C(F)(F)F
Show InChI InChI=1S/C15H11F3N2O3/c16-15(17,18)9-4-5-11(12(7-9)14(22)23)13(21)20-8-10-3-1-2-6-19-10/h1-7H,8H2,(H,20,21)(H,22,23)
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n/an/a 4.80E+3n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM159206
PNG
(US10195186, Example 42 | US9682967, 40)
Show SMILES OC(=O)c1cc(ccc1C(=O)NCc1cccnc1)C(F)(F)F
Show InChI InChI=1S/C15H11F3N2O3/c16-15(17,18)10-3-4-11(12(6-10)14(22)23)13(21)20-8-9-2-1-5-19-7-9/h1-7H,8H2,(H,20,21)(H,22,23)
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n/an/a 5.20E+3n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM159162
PNG
(US10195186, Example 26 | US9682967, 26)
Show SMILES OC(=O)c1cc(Br)ccc1C(=O)Nc1cccnc1
Show InChI InChI=1S/C13H9BrN2O3/c14-8-3-4-10(11(6-8)13(18)19)12(17)16-9-2-1-5-15-7-9/h1-7H,(H,16,17)(H,18,19)
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n/an/a 5.50E+3n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM50445056
PNG
(CHEMBL3098743 | US10195186, Example 3 | US9682967,...)
Show SMILES Cc1ccc(C(=O)Nc2cccc(C)n2)c(c1)C(O)=O
Show InChI InChI=1S/C15H14N2O3/c1-9-6-7-11(12(8-9)15(19)20)14(18)17-13-5-3-4-10(2)16-13/h3-8H,1-2H3,(H,19,20)(H,16,17,18)
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n/an/a 6.40E+3n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
Neurotensin receptor 3


(Homo sapiens)
BDBM50445043
PNG
(CHEMBL3098766 | US10195186, Example 39 | US9682967...)
Show SMILES COc1cccc(NC(=O)c2ccc(cc2C(O)=O)C(F)(F)F)n1
Show InChI InChI=1S/C15H11F3N2O4/c1-24-12-4-2-3-11(19-12)20-13(21)9-6-5-8(15(16,17)18)7-10(9)14(22)23/h2-7H,1H3,(H,22,23)(H,19,20,21)
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n/an/a 7.50E+3n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...


US Patent US10195186 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%