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Patent code US10195201

Compile Data Set for Download or QSAR
Found 75 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM331979
PNG
((R)- or (S)-2- (3,4-dimethoxy- benzyl)-6-(1-(1- (2...)
Show SMILES COc1ccc(Cc2nc(cc(=O)[nH]2)-c2cn(cn2)C(C)c2ccc(cc2F)C(F)(F)F)cc1OC
PDB

UniProtKB/TrEMBL

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UniChem
US Patent
0.200n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)


BindingDB Entry DOI: 10.7270/Q20G3N7K
More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM331979
PNG
((R)- or (S)-2- (3,4-dimethoxy- benzyl)-6-(1-(1- (2...)
Show SMILES COc1ccc(Cc2nc(cc(=O)[nH]2)-c2cn(cn2)C(C)c2ccc(cc2F)C(F)(F)F)cc1OC
PDB

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US Patent
0.400n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)


BindingDB Entry DOI: 10.7270/Q20G3N7K
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM331979
PNG
((R)- or (S)-2- (3,4-dimethoxy- benzyl)-6-(1-(1- (2...)
Show SMILES COc1ccc(Cc2nc(cc(=O)[nH]2)-c2cn(cn2)C(C)c2ccc(cc2F)C(F)(F)F)cc1OC
PDB

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0.400n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
TBD


US Patent US10195201 (2019)


BindingDB Entry DOI: 10.7270/Q20G3N7K
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM331979
PNG
((R)- or (S)-2- (3,4-dimethoxy- benzyl)-6-(1-(1- (2...)
Show SMILES COc1ccc(Cc2nc(cc(=O)[nH]2)-c2cn(cn2)C(C)c2ccc(cc2F)C(F)(F)F)cc1OC
PDB

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1.40n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)


BindingDB Entry DOI: 10.7270/Q20G3N7K
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM332018
PNG
((R)- or (S)-6''- (1-(3-fluoro- 4-(trifluoro- metho...)
Show SMILES CC(c1ccc(OC(F)(F)F)c(F)c1)c1cc(ncn1)-c1cc(=O)[nH]c(C)n1
PDB

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1.80n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
TBD


US Patent US10195201 (2019)


BindingDB Entry DOI: 10.7270/Q20G3N7K
More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM331979
PNG
((R)- or (S)-2- (3,4-dimethoxy- benzyl)-6-(1-(1- (2...)
Show SMILES COc1ccc(Cc2nc(cc(=O)[nH]2)-c2cn(cn2)C(C)c2ccc(cc2F)C(F)(F)F)cc1OC
PDB

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US Patent
2.30n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)


BindingDB Entry DOI: 10.7270/Q20G3N7K
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM332022
PNG
((R)- or (S)-2- methyl-6''-(1- (4-(trifluoro- metho...)
Show SMILES CC(c1ccc(OC(F)(F)F)cc1)c1cc(ncn1)-c1cc(=O)[nH]c(C)n1
PDB

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4.10n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
TBD


US Patent US10195201 (2019)


BindingDB Entry DOI: 10.7270/Q20G3N7K
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM331967
PNG
(US10195201, Example 6 | US10195201, Example 7)
Show SMILES C[C@H](c1nnc(s1)-c1cc(=O)[nH]c(C)n1)c1ccc(cc1)C(F)(F)F
PDB

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6n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)


BindingDB Entry DOI: 10.7270/Q20G3N7K
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM332020
PNG
((R)- or (S)-6''- (1-(3-fluoro- 4-(trifluoro- metho...)
Show SMILES CC(c1ccc(c(F)c1)C(F)(F)F)c1cc(ncn1)-c1cc(=O)[nH]c(C)n1
PDB

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7.5n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
TBD


US Patent US10195201 (2019)


BindingDB Entry DOI: 10.7270/Q20G3N7K
More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM331967
PNG
(US10195201, Example 6 | US10195201, Example 7)
Show SMILES C[C@H](c1nnc(s1)-c1cc(=O)[nH]c(C)n1)c1ccc(cc1)C(F)(F)F
PDB

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10n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)


BindingDB Entry DOI: 10.7270/Q20G3N7K
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM331967
PNG
(US10195201, Example 6 | US10195201, Example 7)
Show SMILES C[C@H](c1nnc(s1)-c1cc(=O)[nH]c(C)n1)c1ccc(cc1)C(F)(F)F
PDB

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12n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
TBD


US Patent US10195201 (2019)


BindingDB Entry DOI: 10.7270/Q20G3N7K
More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM331967
PNG
(US10195201, Example 6 | US10195201, Example 7)
Show SMILES C[C@H](c1nnc(s1)-c1cc(=O)[nH]c(C)n1)c1ccc(cc1)C(F)(F)F
PDB

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13n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)


BindingDB Entry DOI: 10.7270/Q20G3N7K
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM331967
PNG
(US10195201, Example 6 | US10195201, Example 7)
Show SMILES C[C@H](c1nnc(s1)-c1cc(=O)[nH]c(C)n1)c1ccc(cc1)C(F)(F)F
PDB

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13n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)


BindingDB Entry DOI: 10.7270/Q20G3N7K
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM332012
PNG
((R)- or (S)-6''- (1-(4-(difluoro- methoxy)-3- fluo...)
Show SMILES CC(c1ccc(OC(F)F)c(F)c1)c1cc(ncn1)-c1cc(=O)[nH]c(C)n1
PDB

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13n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
TBD


US Patent US10195201 (2019)


BindingDB Entry DOI: 10.7270/Q20G3N7K
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM332004
PNG
(US10195201, Example 30 | US10195201, Example 31)
Show SMILES C[C@H](c1cc(ncn1)-c1cc(=O)[nH]c(C)n1)c1ccc(cc1F)C(F)(F)F
PDB

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16n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
TBD


US Patent US10195201 (2019)


BindingDB Entry DOI: 10.7270/Q20G3N7K
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM331964
PNG
(US10195201, Example 4 | US10195201, Example 5)
Show SMILES C[C@H](c1nnc(s1)-c1cc(=O)[nH]c(C)n1)c1ccc(cc1F)C(F)(F)F
PDB

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18n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
TBD


US Patent US10195201 (2019)


BindingDB Entry DOI: 10.7270/Q20G3N7K
More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM331964
PNG
(US10195201, Example 4 | US10195201, Example 5)
Show SMILES C[C@H](c1nnc(s1)-c1cc(=O)[nH]c(C)n1)c1ccc(cc1F)C(F)(F)F
PDB

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19n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)


BindingDB Entry DOI: 10.7270/Q20G3N7K
More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM331964
PNG
(US10195201, Example 4 | US10195201, Example 5)
Show SMILES C[C@H](c1nnc(s1)-c1cc(=O)[nH]c(C)n1)c1ccc(cc1F)C(F)(F)F
PDB

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20n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)


BindingDB Entry DOI: 10.7270/Q20G3N7K
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM332010
PNG
((R)- or (S)-2- methyl-6''-(1-(4- (trifluoromethyl)...)
Show SMILES CC(c1ccc(cc1)C(F)(F)F)c1cc(ncn1)-c1cc(=O)[nH]c(C)n1
PDB

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20n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
TBD


US Patent US10195201 (2019)


BindingDB Entry DOI: 10.7270/Q20G3N7K
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM332014
PNG
((R)- or (S)-6''- (1-(4-(1,1- difluoro- ethyl)pheny...)
Show SMILES CC(c1ccc(cc1)C(C)(F)F)c1cc(ncn1)-c1cc(=O)[nH]c(C)n1
PDB

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20n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
TBD


US Patent US10195201 (2019)


BindingDB Entry DOI: 10.7270/Q20G3N7K
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM331975
PNG
(US10195201, Example 14 | US10195201, Example 15)
Show SMILES C[C@@H](c1ccc(cc1F)C(F)(F)F)n1cnc(c1)-c1cc(=O)[nH]c(C)n1
PDB

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21n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)


BindingDB Entry DOI: 10.7270/Q20G3N7K
More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM331967
PNG
(US10195201, Example 6 | US10195201, Example 7)
Show SMILES C[C@H](c1nnc(s1)-c1cc(=O)[nH]c(C)n1)c1ccc(cc1)C(F)(F)F
PDB

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21n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)


BindingDB Entry DOI: 10.7270/Q20G3N7K
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM331964
PNG
(US10195201, Example 4 | US10195201, Example 5)
Show SMILES C[C@H](c1nnc(s1)-c1cc(=O)[nH]c(C)n1)c1ccc(cc1F)C(F)(F)F
PDB

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22n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
TBD


US Patent US10195201 (2019)


BindingDB Entry DOI: 10.7270/Q20G3N7K
More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM331975
PNG
(US10195201, Example 14 | US10195201, Example 15)
Show SMILES C[C@@H](c1ccc(cc1F)C(F)(F)F)n1cnc(c1)-c1cc(=O)[nH]c(C)n1
PDB

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24n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)


BindingDB Entry DOI: 10.7270/Q20G3N7K
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM332016
PNG
((R)- or (S)-6''- (1-(4-(difluoro- methyl)-3- fluor...)
Show SMILES CC(c1ccc(C(F)F)c(F)c1)c1cc(ncn1)-c1cc(=O)[nH]c(C)n1
PDB

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30n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
TBD


US Patent US10195201 (2019)


BindingDB Entry DOI: 10.7270/Q20G3N7K
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM332004
PNG
(US10195201, Example 30 | US10195201, Example 31)
Show SMILES C[C@H](c1cc(ncn1)-c1cc(=O)[nH]c(C)n1)c1ccc(cc1F)C(F)(F)F
PDB

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39n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
TBD


US Patent US10195201 (2019)


BindingDB Entry DOI: 10.7270/Q20G3N7K
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM332020
PNG
((R)- or (S)-6''- (1-(3-fluoro- 4-(trifluoro- metho...)
Show SMILES CC(c1ccc(c(F)c1)C(F)(F)F)c1cc(ncn1)-c1cc(=O)[nH]c(C)n1
PDB

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45n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
TBD


US Patent US10195201 (2019)


BindingDB Entry DOI: 10.7270/Q20G3N7K
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM331975
PNG
(US10195201, Example 14 | US10195201, Example 15)
Show SMILES C[C@@H](c1ccc(cc1F)C(F)(F)F)n1cnc(c1)-c1cc(=O)[nH]c(C)n1
PDB

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45n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
TBD


US Patent US10195201 (2019)


BindingDB Entry DOI: 10.7270/Q20G3N7K
More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM331975
PNG
(US10195201, Example 14 | US10195201, Example 15)
Show SMILES C[C@@H](c1ccc(cc1F)C(F)(F)F)n1cnc(c1)-c1cc(=O)[nH]c(C)n1
PDB

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46n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)


BindingDB Entry DOI: 10.7270/Q20G3N7K
More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM331967
PNG
(US10195201, Example 6 | US10195201, Example 7)
Show SMILES C[C@H](c1nnc(s1)-c1cc(=O)[nH]c(C)n1)c1ccc(cc1)C(F)(F)F
PDB

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US Patent
57n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)


BindingDB Entry DOI: 10.7270/Q20G3N7K
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM331961
PNG
(US10195201, Example 1)
Show SMILES CC(c1cnc(s1)-c1cc(=O)[nH]c(C)n1)c1ccc(cc1)C(F)(F)F
PDB

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60n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)


BindingDB Entry DOI: 10.7270/Q20G3N7K
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM331967
PNG
(US10195201, Example 6 | US10195201, Example 7)
Show SMILES C[C@H](c1nnc(s1)-c1cc(=O)[nH]c(C)n1)c1ccc(cc1)C(F)(F)F
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62n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
TBD


US Patent US10195201 (2019)


BindingDB Entry DOI: 10.7270/Q20G3N7K
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM332010
PNG
((R)- or (S)-2- methyl-6''-(1-(4- (trifluoromethyl)...)
Show SMILES CC(c1ccc(cc1)C(F)(F)F)c1cc(ncn1)-c1cc(=O)[nH]c(C)n1
PDB

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64n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
TBD


US Patent US10195201 (2019)


BindingDB Entry DOI: 10.7270/Q20G3N7K
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM332014
PNG
((R)- or (S)-6''- (1-(4-(1,1- difluoro- ethyl)pheny...)
Show SMILES CC(c1ccc(cc1)C(C)(F)F)c1cc(ncn1)-c1cc(=O)[nH]c(C)n1
PDB

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65n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
TBD


US Patent US10195201 (2019)


BindingDB Entry DOI: 10.7270/Q20G3N7K
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM331977
PNG
((R)- or (S)-2- methyl-6-(1-(1- (4-(trifluoro- meth...)
Show SMILES CC(c1ccc(cc1)C(F)(F)F)n1cnc(c1)-c1cc(=O)[nH]c(C)n1
PDB

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76n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)


BindingDB Entry DOI: 10.7270/Q20G3N7K
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM331970
PNG
(US10195201, Example 10 | US10195201, Example 9)
Show SMILES C[C@H](c1nnc(o1)-c1cc(=O)[nH]c(C)n1)c1ccc(cc1)C(F)(F)F
PDB

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79n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)


BindingDB Entry DOI: 10.7270/Q20G3N7K
More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM331970
PNG
(US10195201, Example 10 | US10195201, Example 9)
Show SMILES C[C@H](c1nnc(o1)-c1cc(=O)[nH]c(C)n1)c1ccc(cc1)C(F)(F)F
PDB

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86n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)


BindingDB Entry DOI: 10.7270/Q20G3N7K
More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM331961
PNG
(US10195201, Example 1)
Show SMILES CC(c1cnc(s1)-c1cc(=O)[nH]c(C)n1)c1ccc(cc1)C(F)(F)F
PDB

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96n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)


BindingDB Entry DOI: 10.7270/Q20G3N7K
More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM331977
PNG
((R)- or (S)-2- methyl-6-(1-(1- (4-(trifluoro- meth...)
Show SMILES CC(c1ccc(cc1)C(F)(F)F)n1cnc(c1)-c1cc(=O)[nH]c(C)n1
PDB

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106n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)


BindingDB Entry DOI: 10.7270/Q20G3N7K
More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM331982
PNG
(US10195201, Example 21)
Show SMILES CC(C)C(c1ccc(cc1F)C(F)(F)F)n1cnc(c1)-c1cc(=O)[nH]c(C)n1
PDB

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110n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)


BindingDB Entry DOI: 10.7270/Q20G3N7K
More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM331981
PNG
(US10195201, Example 20)
Show SMILES CCC(c1ccc(cc1F)C(F)(F)F)n1cnc(c1)-c1cc(=O)[nH]c(C)n1
PDB

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123n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)


BindingDB Entry DOI: 10.7270/Q20G3N7K
More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM331970
PNG
(US10195201, Example 10 | US10195201, Example 9)
Show SMILES C[C@H](c1nnc(o1)-c1cc(=O)[nH]c(C)n1)c1ccc(cc1)C(F)(F)F
PDB

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159n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)


BindingDB Entry DOI: 10.7270/Q20G3N7K
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM332016
PNG
((R)- or (S)-6''- (1-(4-(difluoro- methyl)-3- fluor...)
Show SMILES CC(c1ccc(C(F)F)c(F)c1)c1cc(ncn1)-c1cc(=O)[nH]c(C)n1
PDB

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174n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
TBD


US Patent US10195201 (2019)


BindingDB Entry DOI: 10.7270/Q20G3N7K
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM332022
PNG
((R)- or (S)-2- methyl-6''-(1- (4-(trifluoro- metho...)
Show SMILES CC(c1ccc(OC(F)(F)F)cc1)c1cc(ncn1)-c1cc(=O)[nH]c(C)n1
PDB

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194n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
TBD


US Patent US10195201 (2019)


BindingDB Entry DOI: 10.7270/Q20G3N7K
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM332018
PNG
((R)- or (S)-6''- (1-(3-fluoro- 4-(trifluoro- metho...)
Show SMILES CC(c1ccc(OC(F)(F)F)c(F)c1)c1cc(ncn1)-c1cc(=O)[nH]c(C)n1
PDB

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212n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
TBD


US Patent US10195201 (2019)


BindingDB Entry DOI: 10.7270/Q20G3N7K
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM332012
PNG
((R)- or (S)-6''- (1-(4-(difluoro- methoxy)-3- fluo...)
Show SMILES CC(c1ccc(OC(F)F)c(F)c1)c1cc(ncn1)-c1cc(=O)[nH]c(C)n1
PDB

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232n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
TBD


US Patent US10195201 (2019)


BindingDB Entry DOI: 10.7270/Q20G3N7K
More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM331975
PNG
(US10195201, Example 14 | US10195201, Example 15)
Show SMILES C[C@@H](c1ccc(cc1F)C(F)(F)F)n1cnc(c1)-c1cc(=O)[nH]c(C)n1
PDB

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298n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)


BindingDB Entry DOI: 10.7270/Q20G3N7K
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM332026
PNG
(US10195201, Example 48)
Show SMILES CC(c1ccc(cc1)C(F)(F)F)c1cc(nc(C)n1)-c1cc(=O)[nH]c(C)n1
PDB

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312n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)


BindingDB Entry DOI: 10.7270/Q20G3N7K
More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM331977
PNG
((R)- or (S)-2- methyl-6-(1-(1- (4-(trifluoro- meth...)
Show SMILES CC(c1ccc(cc1)C(F)(F)F)n1cnc(c1)-c1cc(=O)[nH]c(C)n1
PDB

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340n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)


BindingDB Entry DOI: 10.7270/Q20G3N7K
More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM331969
PNG
(US10195201, Example 8)
Show SMILES CC(c1cnc(o1)-c1cc(=O)[nH]c(C)n1)c1ccc(cc1)C(F)(F)F
PDB

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352n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)


BindingDB Entry DOI: 10.7270/Q20G3N7K
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM331969
PNG
(US10195201, Example 8)
Show SMILES CC(c1cnc(o1)-c1cc(=O)[nH]c(C)n1)c1ccc(cc1)C(F)(F)F
PDB

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403n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)


BindingDB Entry DOI: 10.7270/Q20G3N7K
More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM331970
PNG
(US10195201, Example 10 | US10195201, Example 9)
Show SMILES C[C@H](c1nnc(o1)-c1cc(=O)[nH]c(C)n1)c1ccc(cc1)C(F)(F)F
PDB

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470n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)


BindingDB Entry DOI: 10.7270/Q20G3N7K
More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM331961
PNG
(US10195201, Example 1)
Show SMILES CC(c1cnc(s1)-c1cc(=O)[nH]c(C)n1)c1ccc(cc1)C(F)(F)F
PDB

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481n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)


BindingDB Entry DOI: 10.7270/Q20G3N7K
More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM332026
PNG
(US10195201, Example 48)
Show SMILES CC(c1ccc(cc1)C(F)(F)F)c1cc(nc(C)n1)-c1cc(=O)[nH]c(C)n1
PDB

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516n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)


BindingDB Entry DOI: 10.7270/Q20G3N7K
More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM331963
PNG
(US10195201, Example 3)
Show SMILES CC(c1csc(n1)-c1cc(=O)[nH]c(C)n1)c1ccc(cc1)C(F)(F)F
PDB

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532n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)


BindingDB Entry DOI: 10.7270/Q20G3N7K
More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM331974
PNG
(US10195201, Example 13)
Show SMILES CC(c1cnc([nH]1)-c1cc(=O)[nH]c(C)n1)c1ccc(cc1)C(F)(F)F
PDB

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631n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)


BindingDB Entry DOI: 10.7270/Q20G3N7K
More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM331970
PNG
(US10195201, Example 10 | US10195201, Example 9)
Show SMILES C[C@H](c1nnc(o1)-c1cc(=O)[nH]c(C)n1)c1ccc(cc1)C(F)(F)F
PDB

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699n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)


BindingDB Entry DOI: 10.7270/Q20G3N7K
More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM331994
PNG
(US10195201, Example 23 | US10195201, Example 24)
Show SMILES C[C@H](c1ccc(cc1)C(F)(F)F)c1cncc(c1)-c1cc(=O)[nH]c(C)n1
PDB

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826n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)


BindingDB Entry DOI: 10.7270/Q20G3N7K
More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM331974
PNG
(US10195201, Example 13)
Show SMILES CC(c1cnc([nH]1)-c1cc(=O)[nH]c(C)n1)c1ccc(cc1)C(F)(F)F
PDB

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868n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)


BindingDB Entry DOI: 10.7270/Q20G3N7K
More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM331985
PNG
(US10195201, Example 22)
Show SMILES CC(c1ccc(cc1)C(F)(F)F)c1ccnc(c1)-c1cc(=O)[nH]c(C)n1
PDB

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868n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)


BindingDB Entry DOI: 10.7270/Q20G3N7K
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM332024
PNG
(US10195201, Example 46 | US10195201, Example 47)
Show SMILES C[C@H](c1ccc(cc1)C(C)(C)O)c1cc(ncn1)-c1cc(=O)[nH]c(C)n1
PDB

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890n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
TBD


US Patent US10195201 (2019)


BindingDB Entry DOI: 10.7270/Q20G3N7K
More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM331985
PNG
(US10195201, Example 22)
Show SMILES CC(c1ccc(cc1)C(F)(F)F)c1ccnc(c1)-c1cc(=O)[nH]c(C)n1
PDB

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920n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)


BindingDB Entry DOI: 10.7270/Q20G3N7K
More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM331994
PNG
(US10195201, Example 23 | US10195201, Example 24)
Show SMILES C[C@H](c1ccc(cc1)C(F)(F)F)c1cncc(c1)-c1cc(=O)[nH]c(C)n1
PDB

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>1.00E+3n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)


BindingDB Entry DOI: 10.7270/Q20G3N7K
More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM331972
PNG
(US10195201, Example 11)
Show SMILES CC(c1nc(no1)-c1cc(=O)[nH]c(C)n1)c1ccc(cc1)C(F)(F)F
PDB

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1.08E+3n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)


BindingDB Entry DOI: 10.7270/Q20G3N7K
More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM331962
PNG
(US10195201, Example 2)
Show SMILES CC(c1nc(cs1)-c1cc(=O)[nH]c(C)n1)c1ccc(cc1)C(F)(F)F
PDB

UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem
US Patent
1.24E+3n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)


BindingDB Entry DOI: 10.7270/Q20G3N7K
More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM331999
PNG
(US10195201, Example 27)
Show SMILES CC(c1ccc(cc1)C(F)(F)F)c1cc(ccn1)-c1cc(=O)[nH]c(C)n1
PDB

UniProtKB/TrEMBL

GoogleScholar
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UniChem
US Patent
1.27E+3n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)


BindingDB Entry DOI: 10.7270/Q20G3N7K
More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM332003
PNG
(US10195201, Example 29)
Show SMILES CC(c1ccc(cc1)C(F)(F)F)c1cncc(n1)-c1cc(=O)[nH]c(C)n1
PDB

UniProtKB/TrEMBL

GoogleScholar
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UniChem
US Patent
1.66E+3n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)


BindingDB Entry DOI: 10.7270/Q20G3N7K
More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM332003
PNG
(US10195201, Example 29)
Show SMILES CC(c1ccc(cc1)C(F)(F)F)c1cncc(n1)-c1cc(=O)[nH]c(C)n1
PDB

UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem
US Patent
1.71E+3n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)


BindingDB Entry DOI: 10.7270/Q20G3N7K
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM332024
PNG
(US10195201, Example 46 | US10195201, Example 47)
Show SMILES C[C@H](c1ccc(cc1)C(C)(C)O)c1cc(ncn1)-c1cc(=O)[nH]c(C)n1
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
1.72E+3n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
TBD


US Patent US10195201 (2019)


BindingDB Entry DOI: 10.7270/Q20G3N7K
More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM331972
PNG
(US10195201, Example 11)
Show SMILES CC(c1nc(no1)-c1cc(=O)[nH]c(C)n1)c1ccc(cc1)C(F)(F)F
PDB

UniProtKB/TrEMBL

GoogleScholar
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UniChem
US Patent
1.75E+3n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)


BindingDB Entry DOI: 10.7270/Q20G3N7K
More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM331998
PNG
(US10195201, Example 26)
Show SMILES Cc1nc(cc(=O)[nH]1)-c1cncc(c1)C(C)(O)c1ccc(cc1)C(F)(F)F
PDB

UniProtKB/TrEMBL

GoogleScholar
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UniChem
US Patent
1.81E+3n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)


BindingDB Entry DOI: 10.7270/Q20G3N7K
More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM331973
PNG
(US10195201, Example 12)
Show SMILES CC(c1noc(n1)-c1cc(=O)[nH]c(C)n1)c1ccc(cc1)C(F)(F)F
PDB

UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem
US Patent
1.87E+3n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)


BindingDB Entry DOI: 10.7270/Q20G3N7K
More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM331973
PNG
(US10195201, Example 12)
Show SMILES CC(c1noc(n1)-c1cc(=O)[nH]c(C)n1)c1ccc(cc1)C(F)(F)F
PDB

UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem
US Patent
2.41E+3n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)


BindingDB Entry DOI: 10.7270/Q20G3N7K
More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM332000
PNG
(US10195201, Example 28)
Show SMILES Cc1nc(cc(=O)[nH]1)-c1ccnc(c1)C(C)(O)c1ccc(cc1)C(F)(F)F
PDB

UniProtKB/TrEMBL

GoogleScholar
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UniChem
US Patent
2.88E+3n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)


BindingDB Entry DOI: 10.7270/Q20G3N7K
More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM331996
PNG
(US10195201, Example 25)
Show SMILES Cc1nc(cc(=O)[nH]1)-c1cncc(c1)C(O)c1ccc(cc1)C(F)(F)F
PDB

UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem
US Patent
1.29E+4n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)


BindingDB Entry DOI: 10.7270/Q20G3N7K
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%