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Patent code US10195201

Compile Data Set for Download or QSAR
Found 75 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM331979
PNG
((R)- or (S)-2- (3,4-dimethoxy- benzyl)-6-(1-(1- (2...)
Show SMILES COc1ccc(Cc2nc(cc(=O)[nH]2)-c2cn(cn2)C(C)c2ccc(cc2F)C(F)(F)F)cc1OC
Show InChI InChI=1S/C25H22F4N4O3/c1-14(17-6-5-16(10-18(17)26)25(27,28)29)33-12-20(30-13-33)19-11-24(34)32-23(31-19)9-15-4-7-21(35-2)22(8-15)36-3/h4-8,10-14H,9H2,1-3H3,(H,31,32,34)
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US Patent
0.200n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)

More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM331979
PNG
((R)- or (S)-2- (3,4-dimethoxy- benzyl)-6-(1-(1- (2...)
Show SMILES COc1ccc(Cc2nc(cc(=O)[nH]2)-c2cn(cn2)C(C)c2ccc(cc2F)C(F)(F)F)cc1OC
Show InChI InChI=1S/C25H22F4N4O3/c1-14(17-6-5-16(10-18(17)26)25(27,28)29)33-12-20(30-13-33)19-11-24(34)32-23(31-19)9-15-4-7-21(35-2)22(8-15)36-3/h4-8,10-14H,9H2,1-3H3,(H,31,32,34)
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0.400n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
TBD


US Patent US10195201 (2019)

More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM331979
PNG
((R)- or (S)-2- (3,4-dimethoxy- benzyl)-6-(1-(1- (2...)
Show SMILES COc1ccc(Cc2nc(cc(=O)[nH]2)-c2cn(cn2)C(C)c2ccc(cc2F)C(F)(F)F)cc1OC
Show InChI InChI=1S/C25H22F4N4O3/c1-14(17-6-5-16(10-18(17)26)25(27,28)29)33-12-20(30-13-33)19-11-24(34)32-23(31-19)9-15-4-7-21(35-2)22(8-15)36-3/h4-8,10-14H,9H2,1-3H3,(H,31,32,34)
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0.400n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)

More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM331979
PNG
((R)- or (S)-2- (3,4-dimethoxy- benzyl)-6-(1-(1- (2...)
Show SMILES COc1ccc(Cc2nc(cc(=O)[nH]2)-c2cn(cn2)C(C)c2ccc(cc2F)C(F)(F)F)cc1OC
Show InChI InChI=1S/C25H22F4N4O3/c1-14(17-6-5-16(10-18(17)26)25(27,28)29)33-12-20(30-13-33)19-11-24(34)32-23(31-19)9-15-4-7-21(35-2)22(8-15)36-3/h4-8,10-14H,9H2,1-3H3,(H,31,32,34)
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1.40n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)

More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM332018
PNG
((R)- or (S)-6''- (1-(3-fluoro- 4-(trifluoro- metho...)
Show SMILES CC(c1ccc(OC(F)(F)F)c(F)c1)c1cc(ncn1)-c1cc(=O)[nH]c(C)n1
Show InChI InChI=1S/C18H14F4N4O2/c1-9(11-3-4-16(12(19)5-11)28-18(20,21)22)13-6-14(24-8-23-13)15-7-17(27)26-10(2)25-15/h3-9H,1-2H3,(H,25,26,27)
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1.80n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
TBD


US Patent US10195201 (2019)

More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM331979
PNG
((R)- or (S)-2- (3,4-dimethoxy- benzyl)-6-(1-(1- (2...)
Show SMILES COc1ccc(Cc2nc(cc(=O)[nH]2)-c2cn(cn2)C(C)c2ccc(cc2F)C(F)(F)F)cc1OC
Show InChI InChI=1S/C25H22F4N4O3/c1-14(17-6-5-16(10-18(17)26)25(27,28)29)33-12-20(30-13-33)19-11-24(34)32-23(31-19)9-15-4-7-21(35-2)22(8-15)36-3/h4-8,10-14H,9H2,1-3H3,(H,31,32,34)
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2.30n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)

More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM332022
PNG
((R)- or (S)-2- methyl-6''-(1- (4-(trifluoro- metho...)
Show SMILES CC(c1ccc(OC(F)(F)F)cc1)c1cc(ncn1)-c1cc(=O)[nH]c(C)n1
Show InChI InChI=1S/C18H15F3N4O2/c1-10(12-3-5-13(6-4-12)27-18(19,20)21)14-7-15(23-9-22-14)16-8-17(26)25-11(2)24-16/h3-10H,1-2H3,(H,24,25,26)
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4.10n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
TBD


US Patent US10195201 (2019)

More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM331967
PNG
(US10195201, Example 6 | US10195201, Example 7)
Show SMILES C[C@H](c1nnc(s1)-c1cc(=O)[nH]c(C)n1)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C16H13F3N4OS/c1-8(10-3-5-11(6-4-10)16(17,18)19)14-22-23-15(25-14)12-7-13(24)21-9(2)20-12/h3-8H,1-2H3,(H,20,21,24)/t8-/m0/s1
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6n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)

More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM332020
PNG
((R)- or (S)-6''- (1-(3-fluoro- 4-(trifluoro- metho...)
Show SMILES CC(c1ccc(c(F)c1)C(F)(F)F)c1cc(ncn1)-c1cc(=O)[nH]c(C)n1
Show InChI InChI=1S/C18H14F4N4O/c1-9(11-3-4-12(13(19)5-11)18(20,21)22)14-6-15(24-8-23-14)16-7-17(27)26-10(2)25-16/h3-9H,1-2H3,(H,25,26,27)
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7.5n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
TBD


US Patent US10195201 (2019)

More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM331967
PNG
(US10195201, Example 6 | US10195201, Example 7)
Show SMILES C[C@H](c1nnc(s1)-c1cc(=O)[nH]c(C)n1)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C16H13F3N4OS/c1-8(10-3-5-11(6-4-10)16(17,18)19)14-22-23-15(25-14)12-7-13(24)21-9(2)20-12/h3-8H,1-2H3,(H,20,21,24)/t8-/m0/s1
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10n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)

More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM331967
PNG
(US10195201, Example 6 | US10195201, Example 7)
Show SMILES C[C@H](c1nnc(s1)-c1cc(=O)[nH]c(C)n1)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C16H13F3N4OS/c1-8(10-3-5-11(6-4-10)16(17,18)19)14-22-23-15(25-14)12-7-13(24)21-9(2)20-12/h3-8H,1-2H3,(H,20,21,24)/t8-/m0/s1
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12n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
TBD


US Patent US10195201 (2019)

More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM331967
PNG
(US10195201, Example 6 | US10195201, Example 7)
Show SMILES C[C@H](c1nnc(s1)-c1cc(=O)[nH]c(C)n1)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C16H13F3N4OS/c1-8(10-3-5-11(6-4-10)16(17,18)19)14-22-23-15(25-14)12-7-13(24)21-9(2)20-12/h3-8H,1-2H3,(H,20,21,24)/t8-/m0/s1
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13n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)

More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM331967
PNG
(US10195201, Example 6 | US10195201, Example 7)
Show SMILES C[C@H](c1nnc(s1)-c1cc(=O)[nH]c(C)n1)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C16H13F3N4OS/c1-8(10-3-5-11(6-4-10)16(17,18)19)14-22-23-15(25-14)12-7-13(24)21-9(2)20-12/h3-8H,1-2H3,(H,20,21,24)/t8-/m0/s1
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13n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)

More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM332012
PNG
((R)- or (S)-6''- (1-(4-(difluoro- methoxy)-3- fluo...)
Show SMILES CC(c1ccc(OC(F)F)c(F)c1)c1cc(ncn1)-c1cc(=O)[nH]c(C)n1
Show InChI InChI=1S/C18H15F3N4O2/c1-9(11-3-4-16(12(19)5-11)27-18(20)21)13-6-14(23-8-22-13)15-7-17(26)25-10(2)24-15/h3-9,18H,1-2H3,(H,24,25,26)
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13n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
TBD


US Patent US10195201 (2019)

More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM332004
PNG
(US10195201, Example 30 | US10195201, Example 31)
Show SMILES C[C@H](c1cc(ncn1)-c1cc(=O)[nH]c(C)n1)c1ccc(cc1F)C(F)(F)F
Show InChI InChI=1S/C18H14F4N4O/c1-9(12-4-3-11(5-13(12)19)18(20,21)22)14-6-15(24-8-23-14)16-7-17(27)26-10(2)25-16/h3-9H,1-2H3,(H,25,26,27)/t9-/m0/s1
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16n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
TBD


US Patent US10195201 (2019)

More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM331964
PNG
(US10195201, Example 4 | US10195201, Example 5)
Show SMILES C[C@H](c1nnc(s1)-c1cc(=O)[nH]c(C)n1)c1ccc(cc1F)C(F)(F)F
Show InChI InChI=1S/C16H12F4N4OS/c1-7(10-4-3-9(5-11(10)17)16(18,19)20)14-23-24-15(26-14)12-6-13(25)22-8(2)21-12/h3-7H,1-2H3,(H,21,22,25)/t7-/m0/s1
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18n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
TBD


US Patent US10195201 (2019)

More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM331964
PNG
(US10195201, Example 4 | US10195201, Example 5)
Show SMILES C[C@H](c1nnc(s1)-c1cc(=O)[nH]c(C)n1)c1ccc(cc1F)C(F)(F)F
Show InChI InChI=1S/C16H12F4N4OS/c1-7(10-4-3-9(5-11(10)17)16(18,19)20)14-23-24-15(26-14)12-6-13(25)22-8(2)21-12/h3-7H,1-2H3,(H,21,22,25)/t7-/m0/s1
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19n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)

More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM331964
PNG
(US10195201, Example 4 | US10195201, Example 5)
Show SMILES C[C@H](c1nnc(s1)-c1cc(=O)[nH]c(C)n1)c1ccc(cc1F)C(F)(F)F
Show InChI InChI=1S/C16H12F4N4OS/c1-7(10-4-3-9(5-11(10)17)16(18,19)20)14-23-24-15(26-14)12-6-13(25)22-8(2)21-12/h3-7H,1-2H3,(H,21,22,25)/t7-/m0/s1
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20n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)

More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM332010
PNG
((R)- or (S)-2- methyl-6''-(1-(4- (trifluoromethyl)...)
Show SMILES CC(c1ccc(cc1)C(F)(F)F)c1cc(ncn1)-c1cc(=O)[nH]c(C)n1
Show InChI InChI=1S/C18H15F3N4O/c1-10(12-3-5-13(6-4-12)18(19,20)21)14-7-15(23-9-22-14)16-8-17(26)25-11(2)24-16/h3-10H,1-2H3,(H,24,25,26)
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20n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
TBD


US Patent US10195201 (2019)

More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM332014
PNG
((R)- or (S)-6''- (1-(4-(1,1- difluoro- ethyl)pheny...)
Show SMILES CC(c1ccc(cc1)C(C)(F)F)c1cc(ncn1)-c1cc(=O)[nH]c(C)n1
Show InChI InChI=1S/C19H18F2N4O/c1-11(13-4-6-14(7-5-13)19(3,20)21)15-8-16(23-10-22-15)17-9-18(26)25-12(2)24-17/h4-11H,1-3H3,(H,24,25,26)
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20n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
TBD


US Patent US10195201 (2019)

More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM331967
PNG
(US10195201, Example 6 | US10195201, Example 7)
Show SMILES C[C@H](c1nnc(s1)-c1cc(=O)[nH]c(C)n1)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C16H13F3N4OS/c1-8(10-3-5-11(6-4-10)16(17,18)19)14-22-23-15(25-14)12-7-13(24)21-9(2)20-12/h3-8H,1-2H3,(H,20,21,24)/t8-/m0/s1
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21n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)

More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM331975
PNG
(US10195201, Example 14 | US10195201, Example 15)
Show SMILES C[C@@H](c1ccc(cc1F)C(F)(F)F)n1cnc(c1)-c1cc(=O)[nH]c(C)n1
Show InChI InChI=1S/C17H14F4N4O/c1-9(12-4-3-11(5-13(12)18)17(19,20)21)25-7-15(22-8-25)14-6-16(26)24-10(2)23-14/h3-9H,1-2H3,(H,23,24,26)/t9-/m0/s1
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21n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)

More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM331964
PNG
(US10195201, Example 4 | US10195201, Example 5)
Show SMILES C[C@H](c1nnc(s1)-c1cc(=O)[nH]c(C)n1)c1ccc(cc1F)C(F)(F)F
Show InChI InChI=1S/C16H12F4N4OS/c1-7(10-4-3-9(5-11(10)17)16(18,19)20)14-23-24-15(26-14)12-6-13(25)22-8(2)21-12/h3-7H,1-2H3,(H,21,22,25)/t7-/m0/s1
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22n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
TBD


US Patent US10195201 (2019)

More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM331975
PNG
(US10195201, Example 14 | US10195201, Example 15)
Show SMILES C[C@@H](c1ccc(cc1F)C(F)(F)F)n1cnc(c1)-c1cc(=O)[nH]c(C)n1
Show InChI InChI=1S/C17H14F4N4O/c1-9(12-4-3-11(5-13(12)18)17(19,20)21)25-7-15(22-8-25)14-6-16(26)24-10(2)23-14/h3-9H,1-2H3,(H,23,24,26)/t9-/m0/s1
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24n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)

More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM332016
PNG
((R)- or (S)-6''- (1-(4-(difluoro- methyl)-3- fluor...)
Show SMILES CC(c1ccc(C(F)F)c(F)c1)c1cc(ncn1)-c1cc(=O)[nH]c(C)n1
Show InChI InChI=1S/C18H15F3N4O/c1-9(11-3-4-12(18(20)21)13(19)5-11)14-6-15(23-8-22-14)16-7-17(26)25-10(2)24-16/h3-9,18H,1-2H3,(H,24,25,26)
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30n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
TBD


US Patent US10195201 (2019)

More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM332004
PNG
(US10195201, Example 30 | US10195201, Example 31)
Show SMILES C[C@H](c1cc(ncn1)-c1cc(=O)[nH]c(C)n1)c1ccc(cc1F)C(F)(F)F
Show InChI InChI=1S/C18H14F4N4O/c1-9(12-4-3-11(5-13(12)19)18(20,21)22)14-6-15(24-8-23-14)16-7-17(27)26-10(2)25-16/h3-9H,1-2H3,(H,25,26,27)/t9-/m0/s1
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39n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
TBD


US Patent US10195201 (2019)

More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM331975
PNG
(US10195201, Example 14 | US10195201, Example 15)
Show SMILES C[C@@H](c1ccc(cc1F)C(F)(F)F)n1cnc(c1)-c1cc(=O)[nH]c(C)n1
Show InChI InChI=1S/C17H14F4N4O/c1-9(12-4-3-11(5-13(12)18)17(19,20)21)25-7-15(22-8-25)14-6-16(26)24-10(2)23-14/h3-9H,1-2H3,(H,23,24,26)/t9-/m0/s1
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45n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
TBD


US Patent US10195201 (2019)

More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM332020
PNG
((R)- or (S)-6''- (1-(3-fluoro- 4-(trifluoro- metho...)
Show SMILES CC(c1ccc(c(F)c1)C(F)(F)F)c1cc(ncn1)-c1cc(=O)[nH]c(C)n1
Show InChI InChI=1S/C18H14F4N4O/c1-9(11-3-4-12(13(19)5-11)18(20,21)22)14-6-15(24-8-23-14)16-7-17(27)26-10(2)25-16/h3-9H,1-2H3,(H,25,26,27)
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45n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
TBD


US Patent US10195201 (2019)

More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM331975
PNG
(US10195201, Example 14 | US10195201, Example 15)
Show SMILES C[C@@H](c1ccc(cc1F)C(F)(F)F)n1cnc(c1)-c1cc(=O)[nH]c(C)n1
Show InChI InChI=1S/C17H14F4N4O/c1-9(12-4-3-11(5-13(12)18)17(19,20)21)25-7-15(22-8-25)14-6-16(26)24-10(2)23-14/h3-9H,1-2H3,(H,23,24,26)/t9-/m0/s1
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46n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)

More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM331967
PNG
(US10195201, Example 6 | US10195201, Example 7)
Show SMILES C[C@H](c1nnc(s1)-c1cc(=O)[nH]c(C)n1)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C16H13F3N4OS/c1-8(10-3-5-11(6-4-10)16(17,18)19)14-22-23-15(25-14)12-7-13(24)21-9(2)20-12/h3-8H,1-2H3,(H,20,21,24)/t8-/m0/s1
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57n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)

More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM331961
PNG
(US10195201, Example 1)
Show SMILES CC(c1cnc(s1)-c1cc(=O)[nH]c(C)n1)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C17H14F3N3OS/c1-9(11-3-5-12(6-4-11)17(18,19)20)14-8-21-16(25-14)13-7-15(24)23-10(2)22-13/h3-9H,1-2H3,(H,22,23,24)
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60n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)

More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM331967
PNG
(US10195201, Example 6 | US10195201, Example 7)
Show SMILES C[C@H](c1nnc(s1)-c1cc(=O)[nH]c(C)n1)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C16H13F3N4OS/c1-8(10-3-5-11(6-4-10)16(17,18)19)14-22-23-15(25-14)12-7-13(24)21-9(2)20-12/h3-8H,1-2H3,(H,20,21,24)/t8-/m0/s1
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62n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
TBD


US Patent US10195201 (2019)

More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM332010
PNG
((R)- or (S)-2- methyl-6''-(1-(4- (trifluoromethyl)...)
Show SMILES CC(c1ccc(cc1)C(F)(F)F)c1cc(ncn1)-c1cc(=O)[nH]c(C)n1
Show InChI InChI=1S/C18H15F3N4O/c1-10(12-3-5-13(6-4-12)18(19,20)21)14-7-15(23-9-22-14)16-8-17(26)25-11(2)24-16/h3-10H,1-2H3,(H,24,25,26)
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64n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
TBD


US Patent US10195201 (2019)

More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM332014
PNG
((R)- or (S)-6''- (1-(4-(1,1- difluoro- ethyl)pheny...)
Show SMILES CC(c1ccc(cc1)C(C)(F)F)c1cc(ncn1)-c1cc(=O)[nH]c(C)n1
Show InChI InChI=1S/C19H18F2N4O/c1-11(13-4-6-14(7-5-13)19(3,20)21)15-8-16(23-10-22-15)17-9-18(26)25-12(2)24-17/h4-11H,1-3H3,(H,24,25,26)
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65n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
TBD


US Patent US10195201 (2019)

More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM331977
PNG
((R)- or (S)-2- methyl-6-(1-(1- (4-(trifluoro- meth...)
Show SMILES CC(c1ccc(cc1)C(F)(F)F)n1cnc(c1)-c1cc(=O)[nH]c(C)n1
Show InChI InChI=1S/C17H15F3N4O/c1-10(12-3-5-13(6-4-12)17(18,19)20)24-8-15(21-9-24)14-7-16(25)23-11(2)22-14/h3-10H,1-2H3,(H,22,23,25)
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76n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)

More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM331970
PNG
(US10195201, Example 10 | US10195201, Example 9)
Show SMILES C[C@H](c1nnc(o1)-c1cc(=O)[nH]c(C)n1)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C16H13F3N4O2/c1-8(10-3-5-11(6-4-10)16(17,18)19)14-22-23-15(25-14)12-7-13(24)21-9(2)20-12/h3-8H,1-2H3,(H,20,21,24)/t8-/m0/s1
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79n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)

More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM331970
PNG
(US10195201, Example 10 | US10195201, Example 9)
Show SMILES C[C@H](c1nnc(o1)-c1cc(=O)[nH]c(C)n1)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C16H13F3N4O2/c1-8(10-3-5-11(6-4-10)16(17,18)19)14-22-23-15(25-14)12-7-13(24)21-9(2)20-12/h3-8H,1-2H3,(H,20,21,24)/t8-/m0/s1
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86n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)

More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM331961
PNG
(US10195201, Example 1)
Show SMILES CC(c1cnc(s1)-c1cc(=O)[nH]c(C)n1)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C17H14F3N3OS/c1-9(11-3-5-12(6-4-11)17(18,19)20)14-8-21-16(25-14)13-7-15(24)23-10(2)22-13/h3-9H,1-2H3,(H,22,23,24)
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96n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)

More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM331977
PNG
((R)- or (S)-2- methyl-6-(1-(1- (4-(trifluoro- meth...)
Show SMILES CC(c1ccc(cc1)C(F)(F)F)n1cnc(c1)-c1cc(=O)[nH]c(C)n1
Show InChI InChI=1S/C17H15F3N4O/c1-10(12-3-5-13(6-4-12)17(18,19)20)24-8-15(21-9-24)14-7-16(25)23-11(2)22-14/h3-10H,1-2H3,(H,22,23,25)
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106n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)

More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM331982
PNG
(US10195201, Example 21)
Show SMILES CC(C)C(c1ccc(cc1F)C(F)(F)F)n1cnc(c1)-c1cc(=O)[nH]c(C)n1
Show InChI InChI=1S/C19H18F4N4O/c1-10(2)18(13-5-4-12(6-14(13)20)19(21,22)23)27-8-16(24-9-27)15-7-17(28)26-11(3)25-15/h4-10,18H,1-3H3,(H,25,26,28)
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110n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)

More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM331981
PNG
(US10195201, Example 20)
Show SMILES CCC(c1ccc(cc1F)C(F)(F)F)n1cnc(c1)-c1cc(=O)[nH]c(C)n1
Show InChI InChI=1S/C18H16F4N4O/c1-3-16(12-5-4-11(6-13(12)19)18(20,21)22)26-8-15(23-9-26)14-7-17(27)25-10(2)24-14/h4-9,16H,3H2,1-2H3,(H,24,25,27)
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123n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)

More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM331970
PNG
(US10195201, Example 10 | US10195201, Example 9)
Show SMILES C[C@H](c1nnc(o1)-c1cc(=O)[nH]c(C)n1)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C16H13F3N4O2/c1-8(10-3-5-11(6-4-10)16(17,18)19)14-22-23-15(25-14)12-7-13(24)21-9(2)20-12/h3-8H,1-2H3,(H,20,21,24)/t8-/m0/s1
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159n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)

More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM332016
PNG
((R)- or (S)-6''- (1-(4-(difluoro- methyl)-3- fluor...)
Show SMILES CC(c1ccc(C(F)F)c(F)c1)c1cc(ncn1)-c1cc(=O)[nH]c(C)n1
Show InChI InChI=1S/C18H15F3N4O/c1-9(11-3-4-12(18(20)21)13(19)5-11)14-6-15(23-8-22-14)16-7-17(26)25-10(2)24-16/h3-9,18H,1-2H3,(H,24,25,26)
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174n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
TBD


US Patent US10195201 (2019)

More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM332022
PNG
((R)- or (S)-2- methyl-6''-(1- (4-(trifluoro- metho...)
Show SMILES CC(c1ccc(OC(F)(F)F)cc1)c1cc(ncn1)-c1cc(=O)[nH]c(C)n1
Show InChI InChI=1S/C18H15F3N4O2/c1-10(12-3-5-13(6-4-12)27-18(19,20)21)14-7-15(23-9-22-14)16-8-17(26)25-11(2)24-16/h3-10H,1-2H3,(H,24,25,26)
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194n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
TBD


US Patent US10195201 (2019)

More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM332018
PNG
((R)- or (S)-6''- (1-(3-fluoro- 4-(trifluoro- metho...)
Show SMILES CC(c1ccc(OC(F)(F)F)c(F)c1)c1cc(ncn1)-c1cc(=O)[nH]c(C)n1
Show InChI InChI=1S/C18H14F4N4O2/c1-9(11-3-4-16(12(19)5-11)28-18(20,21)22)13-6-14(24-8-23-13)15-7-17(27)26-10(2)25-15/h3-9H,1-2H3,(H,25,26,27)
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212n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
TBD


US Patent US10195201 (2019)

More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM332012
PNG
((R)- or (S)-6''- (1-(4-(difluoro- methoxy)-3- fluo...)
Show SMILES CC(c1ccc(OC(F)F)c(F)c1)c1cc(ncn1)-c1cc(=O)[nH]c(C)n1
Show InChI InChI=1S/C18H15F3N4O2/c1-9(11-3-4-16(12(19)5-11)27-18(20)21)13-6-14(23-8-22-13)15-7-17(26)25-10(2)24-15/h3-9,18H,1-2H3,(H,24,25,26)
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232n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
TBD


US Patent US10195201 (2019)

More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM331975
PNG
(US10195201, Example 14 | US10195201, Example 15)
Show SMILES C[C@@H](c1ccc(cc1F)C(F)(F)F)n1cnc(c1)-c1cc(=O)[nH]c(C)n1
Show InChI InChI=1S/C17H14F4N4O/c1-9(12-4-3-11(5-13(12)18)17(19,20)21)25-7-15(22-8-25)14-6-16(26)24-10(2)23-14/h3-9H,1-2H3,(H,23,24,26)/t9-/m0/s1
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298n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)

More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM332026
PNG
(US10195201, Example 48)
Show SMILES CC(c1ccc(cc1)C(F)(F)F)c1cc(nc(C)n1)-c1cc(=O)[nH]c(C)n1
Show InChI InChI=1S/C19H17F3N4O/c1-10(13-4-6-14(7-5-13)19(20,21)22)15-8-16(24-11(2)23-15)17-9-18(27)26-12(3)25-17/h4-10H,1-3H3,(H,25,26,27)
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312n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)

More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM331977
PNG
((R)- or (S)-2- methyl-6-(1-(1- (4-(trifluoro- meth...)
Show SMILES CC(c1ccc(cc1)C(F)(F)F)n1cnc(c1)-c1cc(=O)[nH]c(C)n1
Show InChI InChI=1S/C17H15F3N4O/c1-10(12-3-5-13(6-4-12)17(18,19)20)24-8-15(21-9-24)14-7-16(25)23-11(2)22-14/h3-10H,1-2H3,(H,22,23,25)
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340n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)

More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM331969
PNG
(US10195201, Example 8)
Show SMILES CC(c1cnc(o1)-c1cc(=O)[nH]c(C)n1)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C17H14F3N3O2/c1-9(11-3-5-12(6-4-11)17(18,19)20)14-8-21-16(25-14)13-7-15(24)23-10(2)22-13/h3-9H,1-2H3,(H,22,23,24)
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352n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)

More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM331969
PNG
(US10195201, Example 8)
Show SMILES CC(c1cnc(o1)-c1cc(=O)[nH]c(C)n1)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C17H14F3N3O2/c1-9(11-3-5-12(6-4-11)17(18,19)20)14-8-21-16(25-14)13-7-15(24)23-10(2)22-13/h3-9H,1-2H3,(H,22,23,24)
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403n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)

More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM331970
PNG
(US10195201, Example 10 | US10195201, Example 9)
Show SMILES C[C@H](c1nnc(o1)-c1cc(=O)[nH]c(C)n1)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C16H13F3N4O2/c1-8(10-3-5-11(6-4-10)16(17,18)19)14-22-23-15(25-14)12-7-13(24)21-9(2)20-12/h3-8H,1-2H3,(H,20,21,24)/t8-/m0/s1
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470n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)

More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM331961
PNG
(US10195201, Example 1)
Show SMILES CC(c1cnc(s1)-c1cc(=O)[nH]c(C)n1)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C17H14F3N3OS/c1-9(11-3-5-12(6-4-11)17(18,19)20)14-8-21-16(25-14)13-7-15(24)23-10(2)22-13/h3-9H,1-2H3,(H,22,23,24)
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481n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)

More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM332026
PNG
(US10195201, Example 48)
Show SMILES CC(c1ccc(cc1)C(F)(F)F)c1cc(nc(C)n1)-c1cc(=O)[nH]c(C)n1
Show InChI InChI=1S/C19H17F3N4O/c1-10(13-4-6-14(7-5-13)19(20,21)22)15-8-16(24-11(2)23-15)17-9-18(27)26-12(3)25-17/h4-10H,1-3H3,(H,25,26,27)
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516n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)

More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM331963
PNG
(US10195201, Example 3)
Show SMILES CC(c1csc(n1)-c1cc(=O)[nH]c(C)n1)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C17H14F3N3OS/c1-9(11-3-5-12(6-4-11)17(18,19)20)14-8-25-16(23-14)13-7-15(24)22-10(2)21-13/h3-9H,1-2H3,(H,21,22,24)
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532n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)

More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM331974
PNG
(US10195201, Example 13)
Show SMILES CC(c1cnc([nH]1)-c1cc(=O)[nH]c(C)n1)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C17H15F3N4O/c1-9(11-3-5-12(6-4-11)17(18,19)20)14-8-21-16(24-14)13-7-15(25)23-10(2)22-13/h3-9H,1-2H3,(H,21,24)(H,22,23,25)
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631n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)

More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM331970
PNG
(US10195201, Example 10 | US10195201, Example 9)
Show SMILES C[C@H](c1nnc(o1)-c1cc(=O)[nH]c(C)n1)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C16H13F3N4O2/c1-8(10-3-5-11(6-4-10)16(17,18)19)14-22-23-15(25-14)12-7-13(24)21-9(2)20-12/h3-8H,1-2H3,(H,20,21,24)/t8-/m0/s1
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699n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)

More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM331994
PNG
(US10195201, Example 23 | US10195201, Example 24)
Show SMILES C[C@H](c1ccc(cc1)C(F)(F)F)c1cncc(c1)-c1cc(=O)[nH]c(C)n1
Show InChI InChI=1S/C19H16F3N3O/c1-11(13-3-5-16(6-4-13)19(20,21)22)14-7-15(10-23-9-14)17-8-18(26)25-12(2)24-17/h3-11H,1-2H3,(H,24,25,26)/t11-/m1/s1
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826n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)

More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM331974
PNG
(US10195201, Example 13)
Show SMILES CC(c1cnc([nH]1)-c1cc(=O)[nH]c(C)n1)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C17H15F3N4O/c1-9(11-3-5-12(6-4-11)17(18,19)20)14-8-21-16(24-14)13-7-15(25)23-10(2)22-13/h3-9H,1-2H3,(H,21,24)(H,22,23,25)
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868n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)

More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM331985
PNG
(US10195201, Example 22)
Show SMILES CC(c1ccc(cc1)C(F)(F)F)c1ccnc(c1)-c1cc(=O)[nH]c(C)n1
Show InChI InChI=1S/C19H16F3N3O/c1-11(13-3-5-15(6-4-13)19(20,21)22)14-7-8-23-16(9-14)17-10-18(26)25-12(2)24-17/h3-11H,1-2H3,(H,24,25,26)
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868n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)

More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM332024
PNG
(US10195201, Example 46 | US10195201, Example 47)
Show SMILES C[C@H](c1ccc(cc1)C(C)(C)O)c1cc(ncn1)-c1cc(=O)[nH]c(C)n1
Show InChI InChI=1S/C20H22N4O2/c1-12(14-5-7-15(8-6-14)20(3,4)26)16-9-17(22-11-21-16)18-10-19(25)24-13(2)23-18/h5-12,26H,1-4H3,(H,23,24,25)/t12-/m1/s1
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890n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
TBD


US Patent US10195201 (2019)

More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM331985
PNG
(US10195201, Example 22)
Show SMILES CC(c1ccc(cc1)C(F)(F)F)c1ccnc(c1)-c1cc(=O)[nH]c(C)n1
Show InChI InChI=1S/C19H16F3N3O/c1-11(13-3-5-15(6-4-13)19(20,21)22)14-7-8-23-16(9-14)17-10-18(26)25-12(2)24-17/h3-11H,1-2H3,(H,24,25,26)
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920n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)

More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM331994
PNG
(US10195201, Example 23 | US10195201, Example 24)
Show SMILES C[C@H](c1ccc(cc1)C(F)(F)F)c1cncc(c1)-c1cc(=O)[nH]c(C)n1
Show InChI InChI=1S/C19H16F3N3O/c1-11(13-3-5-16(6-4-13)19(20,21)22)14-7-15(10-23-9-14)17-8-18(26)25-12(2)24-17/h3-11H,1-2H3,(H,24,25,26)/t11-/m1/s1
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>1.00E+3n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)

More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM331972
PNG
(US10195201, Example 11)
Show SMILES CC(c1nc(no1)-c1cc(=O)[nH]c(C)n1)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C16H13F3N4O2/c1-8(10-3-5-11(6-4-10)16(17,18)19)15-22-14(23-25-15)12-7-13(24)21-9(2)20-12/h3-8H,1-2H3,(H,20,21,24)
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1.08E+3n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)

More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM331962
PNG
(US10195201, Example 2)
Show SMILES CC(C1=[S]C=C(N1)c1cc(=O)[nH]c(C)n1)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C17H15F3N3OS/c1-9(11-3-5-12(6-4-11)17(18,19)20)16-23-14(8-25-16)13-7-15(24)22-10(2)21-13/h3-9,23H,1-2H3,(H,21,22,24)
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1.24E+3n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)

More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM331999
PNG
(US10195201, Example 27)
Show SMILES CC(c1ccc(cc1)C(F)(F)F)c1cc(ccn1)-c1cc(=O)[nH]c(C)n1
Show InChI InChI=1S/C19H16F3N3O/c1-11(13-3-5-15(6-4-13)19(20,21)22)16-9-14(7-8-23-16)17-10-18(26)25-12(2)24-17/h3-11H,1-2H3,(H,24,25,26)
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1.27E+3n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)

More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM332003
PNG
(US10195201, Example 29)
Show SMILES CC(c1ccc(cc1)C(F)(F)F)c1cncc(n1)-c1cc(=O)[nH]c(C)n1
Show InChI InChI=1S/C18H15F3N4O/c1-10(12-3-5-13(6-4-12)18(19,20)21)15-8-22-9-16(25-15)14-7-17(26)24-11(2)23-14/h3-10H,1-2H3,(H,23,24,26)
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1.66E+3n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)

More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM332003
PNG
(US10195201, Example 29)
Show SMILES CC(c1ccc(cc1)C(F)(F)F)c1cncc(n1)-c1cc(=O)[nH]c(C)n1
Show InChI InChI=1S/C18H15F3N4O/c1-10(12-3-5-13(6-4-12)18(19,20)21)15-8-22-9-16(25-15)14-7-17(26)24-11(2)23-14/h3-10H,1-2H3,(H,23,24,26)
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1.71E+3n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)

More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM332024
PNG
(US10195201, Example 46 | US10195201, Example 47)
Show SMILES C[C@H](c1ccc(cc1)C(C)(C)O)c1cc(ncn1)-c1cc(=O)[nH]c(C)n1
Show InChI InChI=1S/C20H22N4O2/c1-12(14-5-7-15(8-6-14)20(3,4)26)16-9-17(22-11-21-16)18-10-19(25)24-13(2)23-18/h5-12,26H,1-4H3,(H,23,24,25)/t12-/m1/s1
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1.72E+3n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
TBD


US Patent US10195201 (2019)

More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM331972
PNG
(US10195201, Example 11)
Show SMILES CC(c1nc(no1)-c1cc(=O)[nH]c(C)n1)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C16H13F3N4O2/c1-8(10-3-5-11(6-4-10)16(17,18)19)15-22-14(23-25-15)12-7-13(24)21-9(2)20-12/h3-8H,1-2H3,(H,20,21,24)
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1.75E+3n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)

More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM331998
PNG
(US10195201, Example 26)
Show SMILES Cc1nc(cc(=O)[nH]1)-c1cncc(c1)C(C)(O)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C19H16F3N3O2/c1-11-24-16(8-17(26)25-11)12-7-15(10-23-9-12)18(2,27)13-3-5-14(6-4-13)19(20,21)22/h3-10,27H,1-2H3,(H,24,25,26)
PDB

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US Patent
1.81E+3n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)

More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM331973
PNG
(US10195201, Example 12)
Show SMILES CC(c1noc(n1)-c1cc(=O)[nH]c(C)n1)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C16H13F3N4O2/c1-8(10-3-5-11(6-4-10)16(17,18)19)14-22-15(25-23-14)12-7-13(24)21-9(2)20-12/h3-8H,1-2H3,(H,20,21,24)
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US Patent
1.87E+3n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)

More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM331973
PNG
(US10195201, Example 12)
Show SMILES CC(c1noc(n1)-c1cc(=O)[nH]c(C)n1)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C16H13F3N4O2/c1-8(10-3-5-11(6-4-10)16(17,18)19)14-22-15(25-23-14)12-7-13(24)21-9(2)20-12/h3-8H,1-2H3,(H,20,21,24)
PDB

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US Patent
2.41E+3n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)

More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM332000
PNG
(US10195201, Example 28)
Show SMILES Cc1nc(cc(=O)[nH]1)-c1ccnc(c1)C(C)(O)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C19H16F3N3O2/c1-11-24-15(10-17(26)25-11)12-7-8-23-16(9-12)18(2,27)13-3-5-14(6-4-13)19(20,21)22/h3-10,27H,1-2H3,(H,24,25,26)
PDB

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US Patent
2.88E+3n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)

More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM331996
PNG
(US10195201, Example 25)
Show SMILES Cc1nc(cc(=O)[nH]1)-c1cncc(c1)C(O)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C18H14F3N3O2/c1-10-23-15(7-16(25)24-10)12-6-13(9-22-8-12)17(26)11-2-4-14(5-3-11)18(19,20)21/h2-9,17,26H,1H3,(H,23,24,25)
PDB

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1.29E+4n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US10195201 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%