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Patent code US10196346

Compile Data Set for Download or QSAR
Found 26 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM332030
PNG
((E)-N'-[(2- hydroxynaphthalen-1- yl)methylene]-2-{...)
Show SMILES CN(CCN(C)Cc1cccc2ccccc12)CC(=O)N\N=C\c1c(O)ccc2ccccc12
Show InChI InChI=1S/C28H30N4O2/c1-31(19-23-11-7-10-21-8-3-5-12-24(21)23)16-17-32(2)20-28(34)30-29-18-26-25-13-6-4-9-22(25)14-15-27(26)33/h3-15,18,33H,16-17,19-20H2,1-2H3,(H,30,34)/b29-18+
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US Patent
n/an/an/an/a 830n/an/an/an/a



Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China

US Patent


Assay Description
The compounds were formulated with DMSO to form 30 mM stock solutions, and then formulated with analytical nutrient solution to form 2 working solut...


US Patent US10196346 (2019)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM332048
PNG
((E)-N'-(4-N,N-diethylamino- 2-hydroxybenzal)-2-{N-...)
Show SMILES CCN(CC)c1ccc(\C=N\NC(=O)CN(C)CCN(C)Cc2ccc(cc2)C#N)c(O)c1
Show InChI InChI=1S/C25H34N6O2/c1-5-31(6-2)23-12-11-22(24(32)15-23)17-27-28-25(33)19-30(4)14-13-29(3)18-21-9-7-20(16-26)8-10-21/h7-12,15,17,32H,5-6,13-14,18-19H2,1-4H3,(H,28,33)/b27-17+
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US Patent
n/an/an/an/a 530n/an/an/an/a



Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China

US Patent


Assay Description
The compounds were formulated with DMSO to form 30 mM stock solutions, and then formulated with analytical nutrient solution to form 2 working solut...


US Patent US10196346 (2019)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM332041
PNG
((E)-N'-(4-N,N- diethylamino-2- hydroxybenzal)-2-{N...)
Show SMILES CCN(CC)c1ccc(\C=N\NC(=O)CN(C)CCN(C)Cc2cccc(OC)c2)c(O)c1
Show InChI InChI=1S/C25H37N5O3/c1-6-30(7-2)22-12-11-21(24(31)16-22)17-26-27-25(32)19-29(4)14-13-28(3)18-20-9-8-10-23(15-20)33-5/h8-12,15-17,31H,6-7,13-14,18-19H2,1-5H3,(H,27,32)/b26-17+
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n/an/an/an/a 760n/an/an/an/a



Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China

US Patent


Assay Description
The compounds were formulated with DMSO to form 30 mM stock solutions, and then formulated with analytical nutrient solution to form 2 working solut...


US Patent US10196346 (2019)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM332044
PNG
((E)-N'-[(2- hydroxynaphthalen-1- yl)methylene]-2-{...)
Show SMILES CN(CCN(C)Cc1ccc(cc1)C#N)CC(=O)N\N=C\c1c(O)ccc2ccccc12
Show InChI InChI=1S/C25H27N5O2/c1-29(17-20-9-7-19(15-26)8-10-20)13-14-30(2)18-25(32)28-27-16-23-22-6-4-3-5-21(22)11-12-24(23)31/h3-12,16,31H,13-14,17-18H2,1-2H3,(H,28,32)/b27-16+
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n/an/an/an/a 980n/an/an/an/a



Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China

US Patent


Assay Description
The compounds were formulated with DMSO to form 30 mM stock solutions, and then formulated with analytical nutrient solution to form 2 working solut...


US Patent US10196346 (2019)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM332045
PNG
((E)-N'-(3,5-di-tert-butyl-2- hydroxybenzal)-2-{N-{...)
Show SMILES CN(CCN(C)Cc1ccc(cc1)C#N)CC(=O)N\N=C\c1cc(cc(c1O)C(C)(C)C)C(C)(C)C
Show InChI InChI=1S/C29H41N5O2/c1-28(2,3)24-15-23(27(36)25(16-24)29(4,5)6)18-31-32-26(35)20-34(8)14-13-33(7)19-22-11-9-21(17-30)10-12-22/h9-12,15-16,18,36H,13-14,19-20H2,1-8H3,(H,32,35)/b31-18+
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n/an/an/an/a 7.75E+3n/an/an/an/a



Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China

US Patent


Assay Description
The compounds were formulated with DMSO to form 30 mM stock solutions, and then formulated with analytical nutrient solution to form 2 working solut...


US Patent US10196346 (2019)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM332050
PNG
((E)-N'-(3-ethoxy-2- hydroxybenzal)-2-{N-{2-[N- (4-...)
Show SMILES CCOc1cccc(\C=N\NC(=O)CN(C)CCN(C)Cc2ccc(cc2)C(C)(C)C)c1O
Show InChI InChI=1S/C26H38N4O3/c1-7-33-23-10-8-9-21(25(23)32)17-27-28-24(31)19-30(6)16-15-29(5)18-20-11-13-22(14-12-20)26(2,3)4/h8-14,17,32H,7,15-16,18-19H2,1-6H3,(H,28,31)/b27-17+
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n/an/an/an/a 1.86E+3n/an/an/an/a



Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China

US Patent


Assay Description
The compounds were formulated with DMSO to form 30 mM stock solutions, and then formulated with analytical nutrient solution to form 2 working solut...


US Patent US10196346 (2019)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM332051
PNG
((E)-N'-(4-N,N-diethylamino- 2-hydroxybenzal)-2-{N-...)
Show SMILES CCN(CC)c1ccc(\C=N\NC(=O)CN(C)CCCN(C)Cc2ccc(cc2)C(C)(C)C)c(O)c1
Show InChI InChI=1S/C29H45N5O2/c1-8-34(9-2)26-16-13-24(27(35)19-26)20-30-31-28(36)22-33(7)18-10-17-32(6)21-23-11-14-25(15-12-23)29(3,4)5/h11-16,19-20,35H,8-10,17-18,21-22H2,1-7H3,(H,31,36)/b30-20+
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n/an/an/an/a 130n/an/an/an/a



Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China

US Patent


Assay Description
The compounds were formulated with DMSO to form 30 mM stock solutions, and then formulated with analytical nutrient solution to form 2 working solut...


US Patent US10196346 (2019)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM332028
PNG
((E)-N'-(3,5-di-tert-butyl-2- hydroxybenzal)-2-{N-{...)
Show SMILES CN(CCN(C)Cc1cccc2ccccc12)CC(=O)N\N=C\c1cc(cc(c1O)C(C)(C)C)C(C)(C)C
Show InChI InChI=1S/C32H44N4O2/c1-31(2,3)26-18-25(30(38)28(19-26)32(4,5)6)20-33-34-29(37)22-36(8)17-16-35(7)21-24-14-11-13-23-12-9-10-15-27(23)24/h9-15,18-20,38H,16-17,21-22H2,1-8H3,(H,34,37)/b33-20+
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n/an/an/an/a 1.78E+4n/an/an/an/a



Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China

US Patent


Assay Description
The compounds were formulated with DMSO to form 30 mM stock solutions, and then formulated with analytical nutrient solution to form 2 working solut...


US Patent US10196346 (2019)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM332038
PNG
((E)-N'-(2,3- dihydroxybenzal)-2-{N-{2- [N-(4-isopr...)
Show SMILES CC(C)c1ccc(CN(C)CCN(C)CC(=O)N\N=C\c2cccc(O)c2O)cc1
Show InChI InChI=1S/C23H32N4O3/c1-17(2)19-10-8-18(9-11-19)15-26(3)12-13-27(4)16-22(29)25-24-14-20-6-5-7-21(28)23(20)30/h5-11,14,17,28,30H,12-13,15-16H2,1-4H3,(H,25,29)/b24-14+
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n/an/an/an/a 560n/an/an/an/a



Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China

US Patent


Assay Description
The compounds were formulated with DMSO to form 30 mM stock solutions, and then formulated with analytical nutrient solution to form 2 working solut...


US Patent US10196346 (2019)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM332042
PNG
((E)-N'-(2,3- dihydroxybenzal)-2-{N-{2- [N-(3-metho...)
Show SMILES COc1cccc(CN(C)CCN(C)CC(=O)N\N=C\c2cccc(O)c2O)c1
Show InChI InChI=1S/C21H28N4O4/c1-24(14-16-6-4-8-18(12-16)29-3)10-11-25(2)15-20(27)23-22-13-17-7-5-9-19(26)21(17)28/h4-9,12-13,26,28H,10-11,14-15H2,1-3H3,(H,23,27)/b22-13+
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n/an/an/an/a 820n/an/an/an/a



Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China

US Patent


Assay Description
The compounds were formulated with DMSO to form 30 mM stock solutions, and then formulated with analytical nutrient solution to form 2 working solut...


US Patent US10196346 (2019)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM50042874
PNG
(2,2'-Bipyridin | 2,2'-bipyridine | 2,2'-bipyridyl ...)
Show SMILES c1ccc(nc1)-c1ccccn1
Show InChI InChI=1S/C10H8N2/c1-3-7-11-9(5-1)10-6-2-4-8-12-10/h1-8H
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US Patent
n/an/an/an/a 4.14E+4n/an/an/an/a



Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China

US Patent


Assay Description
The compounds were formulated with DMSO to form 30 mM stock solutions, and then formulated with analytical nutrient solution to form 2 working solut...


US Patent US10196346 (2019)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM332027
PNG
((E)-N'-(3-methoxy-2- hydroxybenzal)-2-{N-{2-[N- (n...)
Show SMILES COc1cccc(\C=N\NC(=O)CN(C)CCN(C)Cc2cccc3ccccc23)c1O
Show InChI InChI=1S/C25H30N4O3/c1-28(17-21-11-6-9-19-8-4-5-12-22(19)21)14-15-29(2)18-24(30)27-26-16-20-10-7-13-23(32-3)25(20)31/h4-13,16,31H,14-15,17-18H2,1-3H3,(H,27,30)/b26-16+
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n/an/an/an/a 2.29E+3n/an/an/an/a



Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China

US Patent


Assay Description
The compounds were formulated with DMSO to form 30 mM stock solutions, and then formulated with analytical nutrient solution to form 2 working solut...


US Patent US10196346 (2019)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM332034
PNG
((E)-N'-(2,3- dihydroxybenzal)-2-{N-{2- [N-(3- trif...)
Show SMILES CN(CCN(C)Cc1cccc(c1)C(F)(F)F)CC(=O)N\N=C\c1cccc(O)c1O
Show InChI InChI=1S/C21H25F3N4O3/c1-27(13-15-5-3-7-17(11-15)21(22,23)24)9-10-28(2)14-19(30)26-25-12-16-6-4-8-18(29)20(16)31/h3-8,11-12,29,31H,9-10,13-14H2,1-2H3,(H,26,30)/b25-12+
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n/an/an/an/a 170n/an/an/an/a



Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China

US Patent


Assay Description
The compounds were formulated with DMSO to form 30 mM stock solutions, and then formulated with analytical nutrient solution to form 2 working solut...


US Patent US10196346 (2019)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM332047
PNG
((E)-N'-(3-ethoxy-2- hydroxybenzal)-2-{N-{2- [N-(4-...)
Show SMILES CCOc1cccc(\C=N\NC(=O)CN(C)CCN(C)Cc2ccc(cc2)C#N)c1O
Show InChI InChI=1S/C23H29N5O3/c1-4-31-21-7-5-6-20(23(21)30)15-25-26-22(29)17-28(3)13-12-27(2)16-19-10-8-18(14-24)9-11-19/h5-11,15,30H,4,12-13,16-17H2,1-3H3,(H,26,29)/b25-15+
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n/an/an/an/a 2.77E+3n/an/an/an/a



Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China

US Patent


Assay Description
The compounds were formulated with DMSO to form 30 mM stock solutions, and then formulated with analytical nutrient solution to form 2 working solut...


US Patent US10196346 (2019)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM332029
PNG
((E)-N'-(3-ethoxy-2- hydroxybenzal)-2-{N-{2- [N-(na...)
Show SMILES CCOc1cccc(\C=N\NC(=O)CN(C)CCN(C)Cc2cccc3ccccc23)c1O
Show InChI InChI=1S/C26H32N4O3/c1-4-33-24-14-8-11-21(26(24)32)17-27-28-25(31)19-30(3)16-15-29(2)18-22-12-7-10-20-9-5-6-13-23(20)22/h5-14,17,32H,4,15-16,18-19H2,1-3H3,(H,28,31)/b27-17+
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n/an/an/an/a 2.11E+3n/an/an/an/a



Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China

US Patent


Assay Description
The compounds were formulated with DMSO to form 30 mM stock solutions, and then formulated with analytical nutrient solution to form 2 working solut...


US Patent US10196346 (2019)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM332031
PNG
((E)-N'-(4-N,N- diethylamino-2- hydroxybenzal)-2-{N...)
Show SMILES CCN(CC)c1ccc(\C=N\NC(=O)CN(C)CCN(C)Cc2cccc3ccccc23)c(O)c1
Show InChI InChI=1S/C28H37N5O2/c1-5-33(6-2)25-15-14-23(27(34)18-25)19-29-30-28(35)21-32(4)17-16-31(3)20-24-12-9-11-22-10-7-8-13-26(22)24/h7-15,18-19,34H,5-6,16-17,20-21H2,1-4H3,(H,30,35)/b29-19+
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n/an/an/an/a 780n/an/an/an/a



Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China

US Patent


Assay Description
The compounds were formulated with DMSO to form 30 mM stock solutions, and then formulated with analytical nutrient solution to form 2 working solut...


US Patent US10196346 (2019)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM332037
PNG
((E)-N'-(3,5-di-tert-butyl-2- hydroxybenzal)-2-{N-{...)
Show SMILES CC(C)c1ccc(CN(C)CCN(C)CC(=O)N\N=C\c2cc(cc(c2O)C(C)(C)C)C(C)(C)C)cc1
Show InChI InChI=1S/C31H48N4O2/c1-22(2)24-13-11-23(12-14-24)20-34(9)15-16-35(10)21-28(36)33-32-19-25-17-26(30(3,4)5)18-27(29(25)37)31(6,7)8/h11-14,17-19,22,37H,15-16,20-21H2,1-10H3,(H,33,36)/b32-19+
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n/an/an/an/a 1.12E+4n/an/an/an/a



Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China

US Patent


Assay Description
The compounds were formulated with DMSO to form 30 mM stock solutions, and then formulated with analytical nutrient solution to form 2 working solut...


US Patent US10196346 (2019)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM332032
PNG
((E)-N'-(3,5-di-tert-butyl-2- hydroxybenzal)-2-{N-{...)
Show SMILES CN(CCN(C)Cc1cccc(c1)C(F)(F)F)CC(=O)N\N=C\c1cc(cc(c1O)C(C)(C)C)C(C)(C)C
Show InChI InChI=1S/C29H41F3N4O2/c1-27(2,3)23-15-21(26(38)24(16-23)28(4,5)6)17-33-34-25(37)19-36(8)13-12-35(7)18-20-10-9-11-22(14-20)29(30,31)32/h9-11,14-17,38H,12-13,18-19H2,1-8H3,(H,34,37)/b33-17+
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n/an/an/an/a 5.23E+3n/an/an/an/a



Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China

US Patent


Assay Description
The compounds were formulated with DMSO to form 30 mM stock solutions, and then formulated with analytical nutrient solution to form 2 working solut...


US Patent US10196346 (2019)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM332036
PNG
((E)-N'-[(2- hydroxynaphthalen-1- yl)methylene]-2-{...)
Show SMILES CC(C)c1ccc(CN(C)CCN(C)CC(=O)N\N=C\c2c(O)ccc3ccccc23)cc1
Show InChI InChI=1S/C27H34N4O2/c1-20(2)22-11-9-21(10-12-22)18-30(3)15-16-31(4)19-27(33)29-28-17-25-24-8-6-5-7-23(24)13-14-26(25)32/h5-14,17,20,32H,15-16,18-19H2,1-4H3,(H,29,33)/b28-17+
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n/an/an/an/a 1.02E+3n/an/an/an/a



Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China

US Patent


Assay Description
The compounds were formulated with DMSO to form 30 mM stock solutions, and then formulated with analytical nutrient solution to form 2 working solut...


US Patent US10196346 (2019)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM332046
PNG
((E)-N'-(3-methoxy-2- hydroxybenzal)-2-{N-{2-[N- (4...)
Show SMILES COc1cccc(\C=N\NC(=O)CN(C)CCN(C)Cc2ccc(cc2)C#N)c1O
Show InChI InChI=1S/C22H27N5O3/c1-26(15-18-9-7-17(13-23)8-10-18)11-12-27(2)16-21(28)25-24-14-19-5-4-6-20(30-3)22(19)29/h4-10,14,29H,11-12,15-16H2,1-3H3,(H,25,28)/b24-14+
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n/an/an/an/a 8.42E+3n/an/an/an/a



Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China

US Patent


Assay Description
The compounds were formulated with DMSO to form 30 mM stock solutions, and then formulated with analytical nutrient solution to form 2 working solut...


US Patent US10196346 (2019)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM332039
PNG
((E)-N'-(3-bromo-6- hydroxybenzal)-2-{N-{2- [N-(4-i...)
Show SMILES CC(C)c1ccc(CN(C)CCN(C)CC(=O)N\N=C\c2cc(Br)ccc2O)cc1
Show InChI InChI=1S/C23H31BrN4O2/c1-17(2)19-7-5-18(6-8-19)15-27(3)11-12-28(4)16-23(30)26-25-14-20-13-21(24)9-10-22(20)29/h5-10,13-14,17,29H,11-12,15-16H2,1-4H3,(H,26,30)/b25-14+
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n/an/an/an/a 2.28E+3n/an/an/an/a



Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China

US Patent


Assay Description
The compounds were formulated with DMSO to form 30 mM stock solutions, and then formulated with analytical nutrient solution to form 2 working solut...


US Patent US10196346 (2019)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM332049
PNG
((E)-N'-(3-methoxy-2- hydroxybenzal)-2-{N-{2-[N- (4...)
Show SMILES COc1cccc(\C=N\NC(=O)CN(C)CCN(C)Cc2ccc(cc2)C(C)(C)C)c1O
Show InChI InChI=1S/C25H36N4O3/c1-25(2,3)21-12-10-19(11-13-21)17-28(4)14-15-29(5)18-23(30)27-26-16-20-8-7-9-22(32-6)24(20)31/h7-13,16,31H,14-15,17-18H2,1-6H3,(H,27,30)/b26-16+
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n/an/an/an/a 2.76E+3n/an/an/an/a



Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China

US Patent


Assay Description
The compounds were formulated with DMSO to form 30 mM stock solutions, and then formulated with analytical nutrient solution to form 2 working solut...


US Patent US10196346 (2019)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM332033
PNG
((E)-N'-(4-N,N- diethylamino-2- hydroxybenzal)-2-{N...)
Show SMILES CCN(CC)c1ccc(\C=N\NC(=O)CN(C)CCN(C)Cc2cccc(c2)C(F)(F)F)c(O)c1
Show InChI InChI=1S/C25H34F3N5O2/c1-5-33(6-2)22-11-10-20(23(34)15-22)16-29-30-24(35)18-32(4)13-12-31(3)17-19-8-7-9-21(14-19)25(26,27)28/h7-11,14-16,34H,5-6,12-13,17-18H2,1-4H3,(H,30,35)/b29-16+
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n/an/an/an/a 600n/an/an/an/a



Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China

US Patent


Assay Description
The compounds were formulated with DMSO to form 30 mM stock solutions, and then formulated with analytical nutrient solution to form 2 working solut...


US Patent US10196346 (2019)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM332040
PNG
((E)-N'-(3,5-di-tert-butyl-2- hydroxybenzal)-2-{N-{...)
Show SMILES COc1cccc(CN(C)CCN(C)CC(=O)N\N=C\c2cc(cc(c2O)C(C)(C)C)C(C)(C)C)c1
Show InChI InChI=1S/C29H44N4O3/c1-28(2,3)23-16-22(27(35)25(17-23)29(4,5)6)18-30-31-26(34)20-33(8)14-13-32(7)19-21-11-10-12-24(15-21)36-9/h10-12,15-18,35H,13-14,19-20H2,1-9H3,(H,31,34)/b30-18+
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n/an/an/an/a 2.77E+3n/an/an/an/a



Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China

US Patent


Assay Description
The compounds were formulated with DMSO to form 30 mM stock solutions, and then formulated with analytical nutrient solution to form 2 working solut...


US Patent US10196346 (2019)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM332043
PNG
((E)-N'-(3-bromo-6- hydroxybenzal)-2-{N-{2- [N-(3-m...)
Show SMILES COc1cccc(CN(C)CCN(C)CC(=O)N\N=C\c2cc(Br)ccc2O)c1
Show InChI InChI=1S/C21H27BrN4O3/c1-25(14-16-5-4-6-19(11-16)29-3)9-10-26(2)15-21(28)24-23-13-17-12-18(22)7-8-20(17)27/h4-8,11-13,27H,9-10,14-15H2,1-3H3,(H,24,28)/b23-13+
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n/an/an/an/a 7.19E+3n/an/an/an/a



Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China

US Patent


Assay Description
The compounds were formulated with DMSO to form 30 mM stock solutions, and then formulated with analytical nutrient solution to form 2 working solut...


US Patent US10196346 (2019)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM332035
PNG
((E)-N'-[(3-ethoxy-2- hydroxybenzal)methylene]- 2-{...)
Show SMILES CCOc1cccc(\C=N\NC(=O)CN(C)CCN(C)Cc2ccc(cc2)C(C)C)c1O
Show InChI InChI=1S/C25H36N4O3/c1-6-32-23-9-7-8-22(25(23)31)16-26-27-24(30)18-29(5)15-14-28(4)17-20-10-12-21(13-11-20)19(2)3/h7-13,16,19,31H,6,14-15,17-18H2,1-5H3,(H,27,30)/b26-16+
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n/an/an/an/a 800n/an/an/an/a



Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China

US Patent


Assay Description
The compounds were formulated with DMSO to form 30 mM stock solutions, and then formulated with analytical nutrient solution to form 2 working solut...


US Patent US10196346 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%