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Patent code US10196369

Compile Data Set for Download or QSAR
Found 103 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332580
PNG
((2E)-1-{2-[(2E)-3-(3,4-dichlorophenyl)prop-2-enoyl...)
Show SMILES Clc1ccc(\C=C\C(=O)N2CC3(C2)CCN(CC3)C(=O)\C=C\c2ccc(Cl)c(Cl)c2)cc1Cl
Show InChI InChI=1S/C25H22Cl4N2O2/c26-19-5-1-17(13-21(19)28)3-7-23(32)30-11-9-25(10-12-30)15-31(16-25)24(33)8-4-18-2-6-20(27)22(29)14-18/h1-8,13-14H,9-12,15-16H2/b7-3+,8-4+
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332546
PNG
((2E)-1-{7-[(2E)-3-(4-bromophenyl)prop-2-enoyl]-2,7...)
Show SMILES Brc1ccc(\C=C\C(=O)N2CC3(C2)CCN(CC3)C(=O)\C=C\c2ccc(Br)cc2)cc1
Show InChI InChI=1S/C25H24Br2N2O2/c26-21-7-1-19(2-8-21)5-11-23(30)28-15-13-25(14-16-28)17-29(18-25)24(31)12-6-20-3-9-22(27)10-4-20/h1-12H,13-18H2/b11-5+,12-6+
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332555
PNG
((2E)-1-{2-[(3,5-dichlorophenyl)carbonyl]-2,7-diaza...)
Show SMILES Clc1cc(Cl)cc(c1)C(=O)N1CC2(C1)CCN(CC2)C(=O)\C=C\c1ccc(Br)cc1
Show InChI InChI=1S/C23H21BrCl2N2O2/c24-18-4-1-16(2-5-18)3-6-21(29)27-9-7-23(8-10-27)14-28(15-23)22(30)17-11-19(25)13-20(26)12-17/h1-6,11-13H,7-10,14-15H2/b6-3+
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332614
PNG
(3-(4-bromophenyl)-1-{2-[(4-chlorophenyl)methyl]-2,...)
Show SMILES Clc1ccc(CN2CC3(C2)CCN(CC3)C(=O)C#Cc2ccc(Br)cc2)cc1
Show InChI InChI=1S/C23H22BrClN2O/c24-20-6-1-18(2-7-20)5-10-22(28)27-13-11-23(12-14-27)16-26(17-23)15-19-3-8-21(25)9-4-19/h1-4,6-9H,11-17H2
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332636
PNG
(3-(4-chlorophenyl)-1-{7-[(4-methoxyphenyl)carbonyl...)
Show SMILES COc1ccc(cc1)C(=O)N1CCC2(CN(C2)C(=O)C#Cc2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C24H23ClN2O3/c1-30-21-9-5-19(6-10-21)23(29)26-14-12-24(13-15-26)16-27(17-24)22(28)11-4-18-2-7-20(25)8-3-18/h2-3,5-10H,12-17H2,1H3
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332641
PNG
(3-(4-fluorophenyl)-1-(7-{[4-(trifluoromethyl)pheny...)
Show SMILES Fc1ccc(cc1)C#CC(=O)N1CC2(C1)CCN(CC2)C(=O)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C24H20F4N2O2/c25-20-8-1-17(2-9-20)3-10-21(31)30-15-23(16-30)11-13-29(14-12-23)22(32)18-4-6-19(7-5-18)24(26,27)28/h1-2,4-9H,11-16H2
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332646
PNG
(5-bromoindol-2-yl 7-{[4-(trifluoromethyl)phenyl]ca...)
Show SMILES FC(F)(F)c1ccc(cc1)C(=O)N1CCC2(CN(C2)C(=O)c2cc3cc(Br)ccc3[nH]2)CC1
Show InChI InChI=1S/C24H21BrF3N3O2/c25-18-5-6-19-16(11-18)12-20(29-19)22(33)31-13-23(14-31)7-9-30(10-8-23)21(32)15-1-3-17(4-2-15)24(26,27)28/h1-6,11-12,29H,7-10,13-14H2
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332550
PNG
(5-chloroindol-2-yl 2-[(4-fluorophenyl)carbonyl]-2,...)
Show SMILES Fc1ccc(cc1)C(=O)N1CC2(C1)CCN(CC2)C(=O)c1cc2cc(Cl)ccc2[nH]1
Show InChI InChI=1S/C23H21ClFN3O2/c24-17-3-6-19-16(11-17)12-20(26-19)22(30)27-9-7-23(8-10-27)13-28(14-23)21(29)15-1-4-18(25)5-2-15/h1-6,11-12,26H,7-10,13-14H2
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332567
PNG
((2E)-3-(4-bromophenyl)-1-(7-{[4-fluoro-3-(trifluor...)
Show SMILES Fc1ccc(cc1C(F)(F)F)C(=O)N1CCC2(CN(C2)C(=O)\C=C\c2ccc(Br)cc2)CC1
Show InChI InChI=1S/C24H21BrF4N2O2/c25-18-5-1-16(2-6-18)3-8-21(32)31-14-23(15-31)9-11-30(12-10-23)22(33)17-4-7-20(26)19(13-17)24(27,28)29/h1-8,13H,9-12,14-15H2/b8-3+
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332588
PNG
(4-({2-[(2E)-3-(4-bromophenyl)prop-2-enoyl]-2,7-dia...)
Show SMILES Fc1cc(ccc1C#N)C(=O)N1CCC2(CN(C2)C(=O)\C=C\c2ccc(Br)cc2)CC1
Show InChI InChI=1S/C24H21BrFN3O2/c25-20-6-1-17(2-7-20)3-8-22(30)29-15-24(16-29)9-11-28(12-10-24)23(31)18-4-5-19(14-27)21(26)13-18/h1-8,13H,9-12,15-16H2/b8-3+
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332589
PNG
((2E)-1-{7-[(3,5-difluorophenyl)carbonyl]-2,7-diaza...)
Show SMILES Fc1cc(F)cc(c1)C(=O)N1CCC2(CN(C2)C(=O)\C=C\c2ccc(Br)cc2)CC1
Show InChI InChI=1S/C23H21BrF2N2O2/c24-18-4-1-16(2-5-18)3-6-21(29)28-14-23(15-28)7-9-27(10-8-23)22(30)17-11-19(25)13-20(26)12-17/h1-6,11-13H,7-10,14-15H2/b6-3+
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332616
PNG
(3-(4-bromophenyl)-1-(2-{[4-(trifluoromethyl)phenyl...)
Show SMILES FC(F)(F)c1ccc(cc1)C(=O)N1CC2(C1)CCN(CC2)C(=O)C#Cc1ccc(Br)cc1
Show InChI InChI=1S/C24H20BrF3N2O2/c25-20-8-1-17(2-9-20)3-10-21(31)29-13-11-23(12-14-29)15-30(16-23)22(32)18-4-6-19(7-5-18)24(26,27)28/h1-2,4-9H,11-16H2
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332618
PNG
(3-(4-bromophenyl)-1-(2-{[4-(trifluoromethyl)phenyl...)
Show SMILES FC(F)(F)c1ccc(CN2CC3(C2)CCN(CC3)C(=O)C#Cc2ccc(Br)cc2)cc1
Show InChI InChI=1S/C24H22BrF3N2O/c25-21-8-3-18(4-9-21)5-10-22(31)30-13-11-23(12-14-30)16-29(17-23)15-19-1-6-20(7-2-19)24(26,27)28/h1-4,6-9H,11-17H2
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332624
PNG
(3-(4-chlorophenyl)-1-(2-{[4-(trifluoromethyl)pheny...)
Show SMILES FC(F)(F)c1ccc(cc1)C(=O)N1CC2(C1)CCN(CC2)C(=O)C#Cc1ccc(Cl)cc1
Show InChI InChI=1S/C24H20ClF3N2O2/c25-20-8-1-17(2-9-20)3-10-21(31)29-13-11-23(12-14-29)15-30(16-23)22(32)18-4-6-19(7-5-18)24(26,27)28/h1-2,4-9H,11-16H2
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332648
PNG
((2E)-3-(4-bromophenyl)-1-{2-[(4-chlorophenyl)carbo...)
Show SMILES Clc1ccc(cc1)C(=O)N1CC2(C1)CCN(CC2)C(=O)\C=C\c1ccc(Br)cc1
Show InChI InChI=1S/C23H22BrClN2O2/c24-19-6-1-17(2-7-19)3-10-21(28)26-13-11-23(12-14-26)15-27(16-23)22(29)18-4-8-20(25)9-5-18/h1-10H,11-16H2/b10-3+
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332552
PNG
((2E)-3-(4-bromophenyl)-1-[2-(phenylcarbonyl)-2,7-d...)
Show SMILES Brc1ccc(\C=C\C(=O)N2CCC3(CN(C3)C(=O)c3ccccc3)CC2)cc1
Show InChI InChI=1S/C23H23BrN2O2/c24-20-9-6-18(7-10-20)8-11-21(27)25-14-12-23(13-15-25)16-26(17-23)22(28)19-4-2-1-3-5-19/h1-11H,12-17H2/b11-8+
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332557
PNG
((2E)-3-(4-bromophenyl)-1-{2-[(3-methylphenyl)carbo...)
Show SMILES Cc1cccc(c1)C(=O)N1CC2(C1)CCN(CC2)C(=O)\C=C\c1ccc(Br)cc1
Show InChI InChI=1S/C24H25BrN2O2/c1-18-3-2-4-20(15-18)23(29)27-16-24(17-27)11-13-26(14-12-24)22(28)10-7-19-5-8-21(25)9-6-19/h2-10,15H,11-14,16-17H2,1H3/b10-7+
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332575
PNG
((2E)-3-(3,4-dichlorophenyl)-1-(7-{[4-(trifluoromet...)
Show SMILES FC(F)(F)c1ccc(cc1)C(=O)N1CCC2(CN(C2)C(=O)\C=C\c2ccc(Cl)c(Cl)c2)CC1
Show InChI InChI=1S/C24H21Cl2F3N2O2/c25-19-7-1-16(13-20(19)26)2-8-21(32)31-14-23(15-31)9-11-30(12-10-23)22(33)17-3-5-18(6-4-17)24(27,28)29/h1-8,13H,9-12,14-15H2/b8-2+
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332598
PNG
((2E)-3-(4-bromophenyl)-1-{2-[(4-fluorophenyl)carbo...)
Show SMILES Fc1ccc(cc1)C(=O)N1CC2(C1)CCN(CC2)C(=O)\C=C\c1ccc(Br)cc1
Show InChI InChI=1S/C23H22BrFN2O2/c24-19-6-1-17(2-7-19)3-10-21(28)26-13-11-23(12-14-26)15-27(16-23)22(29)18-4-8-20(25)9-5-18/h1-10H,11-16H2/b10-3+
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332633
PNG
(3-(4-fluorophenyl)-1-(2-{[4-(trifluoromethyl)pheny...)
Show SMILES Fc1ccc(cc1)C#CC(=O)N1CCC2(CN(C2)C(=O)c2ccc(cc2)C(F)(F)F)CC1
Show InChI InChI=1S/C24H20F4N2O2/c25-20-8-1-17(2-9-20)3-10-21(31)29-13-11-23(12-14-29)15-30(16-23)22(32)18-4-6-19(7-5-18)24(26,27)28/h1-2,4-9H,11-16H2
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332547
PNG
((2E)-3-(4-bromophenyl)-1-{7-[(3-bromophenyl)carbon...)
Show SMILES Brc1ccc(\C=C\C(=O)N2CC3(C2)CCN(CC3)C(=O)c2cccc(Br)c2)cc1
Show InChI InChI=1S/C23H22Br2N2O2/c24-19-7-4-17(5-8-19)6-9-21(28)27-15-23(16-27)10-12-26(13-11-23)22(29)18-2-1-3-20(25)14-18/h1-9,14H,10-13,15-16H2/b9-6+
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332562
PNG
(5-chloroindol-2-yl 2-[(4-fluorophenyl)methyl]-2,7-...)
Show SMILES Fc1ccc(CN2CC3(C2)CCN(CC3)C(=O)c2cc3cc(Cl)ccc3[nH]2)cc1
Show InChI InChI=1S/C23H23ClFN3O/c24-18-3-6-20-17(11-18)12-21(26-20)22(29)28-9-7-23(8-10-28)14-27(15-23)13-16-1-4-19(25)5-2-16/h1-6,11-12,26H,7-10,13-15H2
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332565
PNG
((2E)-3-(4-bromophenyl)-1-{7-[(4-fluorophenyl)carbo...)
Show SMILES Fc1ccc(cc1)C(=O)N1CCC2(CN(C2)C(=O)\C=C\c2ccc(Br)cc2)CC1
Show InChI InChI=1S/C23H22BrFN2O2/c24-19-6-1-17(2-7-19)3-10-21(28)27-15-23(16-27)11-13-26(14-12-23)22(29)18-4-8-20(25)9-5-18/h1-10H,11-16H2/b10-3+
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332574
PNG
((2E)-3-(3,4-dichlorophenyl)-1-{7-[(4-chlorophenyl)...)
Show SMILES Clc1ccc(cc1)C(=O)N1CCC2(CN(C2)C(=O)\C=C\c2ccc(Cl)c(Cl)c2)CC1
Show InChI InChI=1S/C23H21Cl3N2O2/c24-18-5-3-17(4-6-18)22(30)27-11-9-23(10-12-27)14-28(15-23)21(29)8-2-16-1-7-19(25)20(26)13-16/h1-8,13H,9-12,14-15H2/b8-2+
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332585
PNG
(5-chloroindol-2-yl 7-[(4-chlorophenyl)carbonyl]-2,...)
Show SMILES Clc1ccc(cc1)C(=O)N1CCC2(CN(C2)C(=O)c2cc3cc(Cl)ccc3[nH]2)CC1
Show InChI InChI=1S/C23H21Cl2N3O2/c24-17-3-1-15(2-4-17)21(29)27-9-7-23(8-10-27)13-28(14-23)22(30)20-12-16-11-18(25)5-6-19(16)26-20/h1-6,11-12,26H,7-10,13-14H2
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332591
PNG
(5-bromoindol-2-yl 7-[(4-bromophenyl)carbonyl]-2,7-...)
Show SMILES Brc1ccc(cc1)C(=O)N1CCC2(CN(C2)C(=O)c2cc3cc(Br)ccc3[nH]2)CC1
Show InChI InChI=1S/C23H21Br2N3O2/c24-17-3-1-15(2-4-17)21(29)27-9-7-23(8-10-27)13-28(14-23)22(30)20-12-16-11-18(25)5-6-19(16)26-20/h1-6,11-12,26H,7-10,13-14H2
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332597
PNG
((2E)-3-(4-bromophenyl)-1-(2-{[4-fluoro-2-(trifluor...)
Show SMILES Fc1ccc(C(=O)N2CC3(C2)CCN(CC3)C(=O)\C=C\c2ccc(Br)cc2)c(c1)C(F)(F)F
Show InChI InChI=1S/C24H21BrF4N2O2/c25-17-4-1-16(2-5-17)3-8-21(32)30-11-9-23(10-12-30)14-31(15-23)22(33)19-7-6-18(26)13-20(19)24(27,28)29/h1-8,13H,9-12,14-15H2/b8-3+
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332625
PNG
(3-(4-chlorophenyl)-1-(7-{[4-(trifluoromethyl)pheny...)
Show SMILES FC(F)(F)c1ccc(cc1)C(=O)N1CCC2(CN(C2)C(=O)C#Cc2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C24H20ClF3N2O2/c25-20-8-1-17(2-9-20)3-10-21(31)30-15-23(16-30)11-13-29(14-12-23)22(32)18-4-6-19(7-5-18)24(26,27)28/h1-2,4-9H,11-16H2
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332629
PNG
(3-(4-chlorophenyl)-1-{7-[(4-chlorophenyl)carbonyl]...)
Show SMILES Clc1ccc(cc1)C#CC(=O)N1CC2(C1)CCN(CC2)C(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H20Cl2N2O2/c24-19-6-1-17(2-7-19)3-10-21(28)27-15-23(16-27)11-13-26(14-12-23)22(29)18-4-8-20(25)9-5-18/h1-2,4-9H,11-16H2
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332632
PNG
(1-{2-[(4-chlorophenyl)carbonyl]-2,7-diazaspiro[3.5...)
Show SMILES Fc1ccc(cc1)C#CC(=O)N1CCC2(CN(C2)C(=O)c2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C23H20ClFN2O2/c24-19-6-4-18(5-7-19)22(29)27-15-23(16-27)11-13-26(14-12-23)21(28)10-3-17-1-8-20(25)9-2-17/h1-2,4-9H,11-16H2
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332553
PNG
((2E)-3-(4-bromophenyl)-1-{2-[(4-fluorophenyl)methy...)
Show SMILES Fc1ccc(CN2CC3(C2)CCN(CC3)C(=O)\C=C\c2ccc(Br)cc2)cc1
Show InChI InChI=1S/C23H24BrFN2O/c24-20-6-1-18(2-7-20)5-10-22(28)27-13-11-23(12-14-27)16-26(17-23)15-19-3-8-21(25)9-4-19/h1-10H,11-17H2/b10-5+
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332556
PNG
((2E)-1-{2-[(2,6-dichlorophenyl)methyl]-2,7-diazasp...)
Show SMILES Clc1cccc(Cl)c1CN1CC2(C1)CCN(CC2)C(=O)\C=C\c1ccc(Br)cc1
Show InChI InChI=1S/C23H23BrCl2N2O/c24-18-7-4-17(5-8-18)6-9-22(29)28-12-10-23(11-13-28)15-27(16-23)14-19-20(25)2-1-3-21(19)26/h1-9H,10-16H2/b9-6+
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332564
PNG
((2E)-3-(4-bromophenyl)-1-{7-[(4-chlorophenyl)carbo...)
Show SMILES Clc1ccc(cc1)C(=O)N1CCC2(CN(C2)C(=O)\C=C\c2ccc(Br)cc2)CC1
Show InChI InChI=1S/C23H22BrClN2O2/c24-19-6-1-17(2-7-19)3-10-21(28)27-15-23(16-27)11-13-26(14-12-23)22(29)18-4-8-20(25)9-5-18/h1-10H,11-16H2/b10-3+
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332573
PNG
((2E)-3-(3,4-dichlorophenyl)-1-{7-[(4-fluorophenyl)...)
Show SMILES Fc1ccc(cc1)C(=O)N1CCC2(CN(C2)C(=O)\C=C\c2ccc(Cl)c(Cl)c2)CC1
Show InChI InChI=1S/C23H21Cl2FN2O2/c24-19-7-1-16(13-20(19)25)2-8-21(29)28-14-23(15-28)9-11-27(12-10-23)22(30)17-3-5-18(26)6-4-17/h1-8,13H,9-12,14-15H2/b8-2+
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332584
PNG
(5-chloroindol-2-yl 7-{[4-(trifluoromethyl)phenyl]c...)
Show SMILES FC(F)(F)c1ccc(cc1)C(=O)N1CCC2(CN(C2)C(=O)c2cc3cc(Cl)ccc3[nH]2)CC1
Show InChI InChI=1S/C24H21ClF3N3O2/c25-18-5-6-19-16(11-18)12-20(29-19)22(33)31-13-23(14-31)7-9-30(10-8-23)21(32)15-1-3-17(4-2-15)24(26,27)28/h1-6,11-12,29H,7-10,13-14H2
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332593
PNG
(5-bromoindol-2-yl 7-{[4-fluoro-2-(trifluoromethyl)...)
Show SMILES Fc1ccc(C(=O)N2CCC3(CN(C3)C(=O)c3cc4cc(Br)ccc4[nH]3)CC2)c(c1)C(F)(F)F
Show InChI InChI=1S/C24H20BrF4N3O2/c25-15-1-4-19-14(9-15)10-20(30-19)22(34)32-12-23(13-32)5-7-31(8-6-23)21(33)17-3-2-16(26)11-18(17)24(27,28)29/h1-4,9-11,30H,5-8,12-13H2
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332613
PNG
(3-(4-bromophenyl)-1-{2-[(4-fluorophenyl)methyl]-2,...)
Show SMILES Fc1ccc(CN2CC3(C2)CCN(CC3)C(=O)C#Cc2ccc(Br)cc2)cc1
Show InChI InChI=1S/C23H22BrFN2O/c24-20-6-1-18(2-7-20)5-10-22(28)27-13-11-23(12-14-27)16-26(17-23)15-19-3-8-21(25)9-4-19/h1-4,6-9H,11-17H2
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332617
PNG
(3-(4-bromophenyl)-1-{2-[(4-bromophenyl)methyl]-2,7...)
Show SMILES Brc1ccc(CN2CC3(C2)CCN(CC3)C(=O)C#Cc2ccc(Br)cc2)cc1
Show InChI InChI=1S/C23H22Br2N2O/c24-20-6-1-18(2-7-20)5-10-22(28)27-13-11-23(12-14-27)16-26(17-23)15-19-3-8-21(25)9-4-19/h1-4,6-9H,11-17H2
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332619
PNG
(3-(4-bromophenyl)-1-{2-[(4-methoxyphenyl)carbonyl]...)
Show SMILES COc1ccc(cc1)C(=O)N1CC2(C1)CCN(CC2)C(=O)C#Cc1ccc(Br)cc1
Show InChI InChI=1S/C24H23BrN2O3/c1-30-21-9-5-19(6-10-21)23(29)27-16-24(17-27)12-14-26(15-13-24)22(28)11-4-18-2-7-20(25)8-3-18/h2-3,5-10H,12-17H2,1H3
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332622
PNG
(3-(4-chlorophenyl)-1-{2-[(4-fluorophenyl)carbonyl]...)
Show SMILES Fc1ccc(cc1)C(=O)N1CC2(C1)CCN(CC2)C(=O)C#Cc1ccc(Cl)cc1
Show InChI InChI=1S/C23H20ClFN2O2/c24-19-6-1-17(2-7-19)3-10-21(28)26-13-11-23(12-14-26)15-27(16-23)22(29)18-4-8-20(25)9-5-18/h1-2,4-9H,11-16H2
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332554
PNG
((2E)-1-{2-[(3,4-dimethoxyphenyl)carbonyl]-2,7-diaz...)
Show SMILES COc1ccc(cc1OC)C(=O)N1CC2(C1)CCN(CC2)C(=O)\C=C\c1ccc(Br)cc1
Show InChI InChI=1S/C25H27BrN2O4/c1-31-21-9-6-19(15-22(21)32-2)24(30)28-16-25(17-28)11-13-27(14-12-25)23(29)10-5-18-3-7-20(26)8-4-18/h3-10,15H,11-14,16-17H2,1-2H3/b10-5+
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332563
PNG
(5-chloroindol-2-yl 7-{[3-fluoro-4-(trifluoromethyl...)
Show SMILES Fc1cc(ccc1C(F)(F)F)C(=O)N1CCC2(CN(C2)C(=O)c2cc3cc(Cl)ccc3[nH]2)CC1
Show InChI InChI=1S/C24H20ClF4N3O2/c25-16-2-4-19-15(9-16)11-20(30-19)22(34)32-12-23(13-32)5-7-31(8-6-23)21(33)14-1-3-17(18(26)10-14)24(27,28)29/h1-4,9-11,30H,5-8,12-13H2
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332621
PNG
(3-(4-chlorophenyl)-1-{2-[(4-chlorophenyl)carbonyl]...)
Show SMILES Clc1ccc(cc1)C#CC(=O)N1CCC2(CN(C2)C(=O)c2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C23H20Cl2N2O2/c24-19-6-1-17(2-7-19)3-10-21(28)26-13-11-23(12-14-26)15-27(16-23)22(29)18-4-8-20(25)9-5-18/h1-2,4-9H,11-16H2
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332623
PNG
(3-(4-chlorophenyl)-1-(2-{[4-(trifluoromethyl)pheny...)
Show SMILES FC(F)(F)c1ccc(CN2CC3(C2)CCN(CC3)C(=O)C#Cc2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C24H22ClF3N2O/c25-21-8-3-18(4-9-21)5-10-22(31)30-13-11-23(12-14-30)16-29(17-23)15-19-1-6-20(7-2-19)24(26,27)28/h1-4,6-9H,11-17H2
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332645
PNG
(5-chloroindol-2-yl 9-{[3-fluoro-4-(trifluoromethyl...)
Show SMILES Fc1cc(ccc1C(F)(F)F)C(=O)N1CCC2(CCN(CC2)C(=O)c2cc3cc(Cl)ccc3[nH]2)CC1
Show InChI InChI=1S/C26H24ClF4N3O2/c27-18-2-4-21-17(13-18)15-22(32-21)24(36)34-11-7-25(8-12-34)5-9-33(10-6-25)23(35)16-1-3-19(20(28)14-16)26(29,30)31/h1-4,13-15,32H,5-12H2
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332549
PNG
(5-chloroindol-2-yl 2-[(3-fluorophenyl)methyl]-2,7-...)
Show SMILES Fc1cccc(CN2CC3(C2)CCN(CC3)C(=O)c2cc3cc(Cl)ccc3[nH]2)c1
Show InChI InChI=1S/C23H23ClFN3O/c24-18-4-5-20-17(11-18)12-21(26-20)22(29)28-8-6-23(7-9-28)14-27(15-23)13-16-2-1-3-19(25)10-16/h1-5,10-12,26H,6-9,13-15H2
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332551
PNG
((2E)-3-(4-bromophenyl)-1-{2-[(4-chlorophenyl)methy...)
Show SMILES Clc1ccc(CN2CC3(C2)CCN(CC3)C(=O)\C=C\c2ccc(Br)cc2)cc1
Show InChI InChI=1S/C23H24BrClN2O/c24-20-6-1-18(2-7-20)5-10-22(28)27-13-11-23(12-14-27)16-26(17-23)15-19-3-8-21(25)9-4-19/h1-10H,11-17H2/b10-5+
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332566
PNG
((2E)-3-(4-bromophenyl)-1-(7-{[4-(trifluoromethyl)p...)
Show SMILES FC(F)(F)c1ccc(cc1)C(=O)N1CCC2(CN(C2)C(=O)\C=C\c2ccc(Br)cc2)CC1
Show InChI InChI=1S/C24H22BrF3N2O2/c25-20-8-1-17(2-9-20)3-10-21(31)30-15-23(16-30)11-13-29(14-12-23)22(32)18-4-6-19(7-5-18)24(26,27)28/h1-10H,11-16H2/b10-3+
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332590
PNG
((2E)-3-(4-bromophenyl)-1-(7-{[4-fluoro-2-(trifluor...)
Show SMILES Fc1ccc(C(=O)N2CCC3(CN(C3)C(=O)\C=C\c3ccc(Br)cc3)CC2)c(c1)C(F)(F)F
Show InChI InChI=1S/C24H21BrF4N2O2/c25-17-4-1-16(2-5-17)3-8-21(32)31-14-23(15-31)9-11-30(12-10-23)22(33)19-7-6-18(26)13-20(19)24(27,28)29/h1-8,13H,9-12,14-15H2/b8-3+
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332596
PNG
((2E)-1-{7-[(4-aminophenyl)carbonyl]-2,7-diazaspiro...)
Show SMILES Nc1ccc(cc1)C(=O)N1CCC2(CN(C2)C(=O)\C=C\c2ccc(Br)cc2)CC1
Show InChI InChI=1S/C23H24BrN3O2/c24-19-6-1-17(2-7-19)3-10-21(28)27-15-23(16-27)11-13-26(14-12-23)22(29)18-4-8-20(25)9-5-18/h1-10H,11-16,25H2/b10-3+
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332599
PNG
((2E)-3-(4-bromophenyl)-1-(2-{[4-(trifluoromethyl)p...)
Show SMILES FC(F)(F)c1ccc(cc1)C(=O)N1CC2(C1)CCN(CC2)C(=O)\C=C\c1ccc(Br)cc1
Show InChI InChI=1S/C24H22BrF3N2O2/c25-20-8-1-17(2-9-20)3-10-21(31)29-13-11-23(12-14-29)15-30(16-23)22(32)18-4-6-19(7-5-18)24(26,27)28/h1-10H,11-16H2/b10-3+
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332627
PNG
(3-(4-chlorophenyl)-1-{2-[(4-chlorophenyl)methyl]-2...)
Show SMILES Clc1ccc(CN2CC3(C2)CCN(CC3)C(=O)C#Cc2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C23H22Cl2N2O/c24-20-6-1-18(2-7-20)5-10-22(28)27-13-11-23(12-14-27)16-26(17-23)15-19-3-8-21(25)9-4-19/h1-4,6-9H,11-17H2
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332640
PNG
(1-{7-[(4-bromophenyl)carbonyl]-2,7-diazaspiro[3.5]...)
Show SMILES Fc1ccc(cc1)C#CC(=O)N1CC2(C1)CCN(CC2)C(=O)c1ccc(Br)cc1
Show InChI InChI=1S/C23H20BrFN2O2/c24-19-6-4-18(5-7-19)22(29)26-13-11-23(12-14-26)15-27(16-23)21(28)10-3-17-1-8-20(25)9-2-17/h1-2,4-9H,11-16H2
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332548
PNG
(3-(4-chlorophenyl)-1-{7-[(4-fluorophenyl)carbonyl]...)
Show SMILES Fc1ccc(cc1)C(=O)N1CCC2(CN(C2)C(=O)C#Cc2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C23H20ClFN2O2/c24-19-6-1-17(2-7-19)3-10-21(28)27-15-23(16-27)11-13-26(14-12-23)22(29)18-4-8-20(25)9-5-18/h1-2,4-9H,11-16H2
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332630
PNG
(3-(4-chlorophenyl)-1-{7-[(4-chlorophenyl)methyl]-2...)
Show SMILES Clc1ccc(CN2CCC3(CN(C3)C(=O)C#Cc3ccc(Cl)cc3)CC2)cc1
Show InChI InChI=1S/C23H22Cl2N2O/c24-20-6-1-18(2-7-20)5-10-22(28)27-16-23(17-27)11-13-26(14-12-23)15-19-3-8-21(25)9-4-19/h1-4,6-9H,11-17H2
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332570
PNG
((2E)-3-(4-bromophenyl)-1-{7-[(4-fluorophenyl)methy...)
Show SMILES Fc1ccc(CN2CCC3(CN(C3)C(=O)\C=C\c3ccc(Br)cc3)CC2)cc1
Show InChI InChI=1S/C23H24BrFN2O/c24-20-6-1-18(2-7-20)5-10-22(28)27-16-23(17-27)11-13-26(14-12-23)15-19-3-8-21(25)9-4-19/h1-10H,11-17H2/b10-5+
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332579
PNG
((2E)-3-(3,4-dichlorophenyl)-1-(7-{[3-fluoro-4-(tri...)
Show SMILES Fc1cc(CN2CCC3(CN(C3)C(=O)\C=C\c3ccc(Cl)c(Cl)c3)CC2)ccc1C(F)(F)F
Show InChI InChI=1S/C24H22Cl2F4N2O/c25-19-5-2-16(11-20(19)26)3-6-22(33)32-14-23(15-32)7-9-31(10-8-23)13-17-1-4-18(21(27)12-17)24(28,29)30/h1-6,11-12H,7-10,13-15H2/b6-3+
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332583
PNG
(5-chloroindol-2-yl 7-[(4-fluorophenyl)carbonyl]-2,...)
Show SMILES Fc1ccc(cc1)C(=O)N1CCC2(CN(C2)C(=O)c2cc3cc(Cl)ccc3[nH]2)CC1
Show InChI InChI=1S/C23H21ClFN3O2/c24-17-3-6-19-16(11-17)12-20(26-19)22(30)28-13-23(14-28)7-9-27(10-8-23)21(29)15-1-4-18(25)5-2-15/h1-6,11-12,26H,7-10,13-14H2
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332615
PNG
(3-(4-bromophenyl)-1-{2-[(4-chlorophenyl)carbonyl]-...)
Show SMILES Clc1ccc(cc1)C(=O)N1CC2(C1)CCN(CC2)C(=O)C#Cc1ccc(Br)cc1
Show InChI InChI=1S/C23H20BrClN2O2/c24-19-6-1-17(2-7-19)3-10-21(28)26-13-11-23(12-14-26)15-27(16-23)22(29)18-4-8-20(25)9-5-18/h1-2,4-9H,11-16H2
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332558
PNG
(5-chloroindol-2-yl 2-{[3-fluoro-4-(trifluoromethyl...)
Show SMILES Fc1cc(ccc1C(F)(F)F)C(=O)N1CC2(C1)CCN(CC2)C(=O)c1cc2cc(Cl)ccc2[nH]1
Show InChI InChI=1S/C24H20ClF4N3O2/c25-16-2-4-19-15(9-16)11-20(30-19)22(34)31-7-5-23(6-8-31)12-32(13-23)21(33)14-1-3-17(18(26)10-14)24(27,28)29/h1-4,9-11,30H,5-8,12-13H2
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332578
PNG
((2E)-3-(3,4-dichlorophenyl)-1-{7-[(4-chlorophenyl)...)
Show SMILES Clc1ccc(CN2CCC3(CN(C3)C(=O)\C=C\c3ccc(Cl)c(Cl)c3)CC2)cc1
Show InChI InChI=1S/C23H23Cl3N2O/c24-19-5-1-18(2-6-19)14-27-11-9-23(10-12-27)15-28(16-23)22(29)8-4-17-3-7-20(25)21(26)13-17/h1-8,13H,9-12,14-16H2/b8-4+
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332568
PNG
((2E)-3-(4-bromophenyl)-1-{7-[(4-(1H-1,2,3,4-tetraa...)
Show SMILES Brc1ccc(\C=C\C(=O)N2CC3(C2)CCN(CC3)C(=O)c2ccc(cc2)-c2nnn[nH]2)cc1
Show InChI InChI=1S/C24H23BrN6O2/c25-20-8-1-17(2-9-20)3-10-21(32)31-15-24(16-31)11-13-30(14-12-24)23(33)19-6-4-18(5-7-19)22-26-28-29-27-22/h1-10H,11-16H2,(H,26,27,28,29)/b10-3+
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332606
PNG
(6-bromoindol-2-yl 7-{[4-fluoro-2-(trifluoromethyl)...)
Show SMILES Fc1ccc(C(=O)N2CCC3(CN(C3)C(=O)c3cc4ccc(Br)cc4[nH]3)CC2)c(c1)C(F)(F)F
Show InChI InChI=1S/C24H20BrF4N3O2/c25-15-2-1-14-9-20(30-19(14)10-15)22(34)32-12-23(13-32)5-7-31(8-6-23)21(33)17-4-3-16(26)11-18(17)24(27,28)29/h1-4,9-11,30H,5-8,12-13H2
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332569
PNG
((2E)-1-(7-{[3,5-bis(trifluoromethyl)phenyl]methyl}...)
Show SMILES FC(F)(F)c1cc(CN2CCC3(CN(C3)C(=O)\C=C\c3ccc(Br)cc3)CC2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C25H23BrF6N2O/c26-21-4-1-17(2-5-21)3-6-22(35)34-15-23(16-34)7-9-33(10-8-23)14-18-11-19(24(27,28)29)13-20(12-18)25(30,31)32/h1-6,11-13H,7-10,14-16H2/b6-3+
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332639
PNG
(1-{7-[(4-chlorophenyl)carbonyl]-2,7-diazaspiro[3.5...)
Show SMILES Fc1ccc(cc1)C#CC(=O)N1CC2(C1)CCN(CC2)C(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H20ClFN2O2/c24-19-6-4-18(5-7-19)22(29)26-13-11-23(12-14-26)15-27(16-23)21(28)10-3-17-1-8-20(25)9-2-17/h1-2,4-9H,11-16H2
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332635
PNG
(3-(4-fluorophenyl)-1-(2-{[4-fluoro-2-(trifluoromet...)
Show SMILES Fc1ccc(cc1)C#CC(=O)N1CCC2(CN(Cc3ccc(F)cc3C(F)(F)F)C2)CC1
Show InChI InChI=1S/C24H21F5N2O/c25-19-5-1-17(2-6-19)3-8-22(32)31-11-9-23(10-12-31)15-30(16-23)14-18-4-7-20(26)13-21(18)24(27,28)29/h1-2,4-7,13H,9-12,14-16H2
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n/an/a 12.5n/an/an/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332626
PNG
(3-(4-chlorophenyl)-1-{7-[(4-fluorophenyl)methyl]-2...)
Show SMILES Fc1ccc(CN2CCC3(CN(C3)C(=O)C#Cc3ccc(Cl)cc3)CC2)cc1
Show InChI InChI=1S/C23H22ClFN2O/c24-20-6-1-18(2-7-20)5-10-22(28)27-16-23(17-27)11-13-26(14-12-23)15-19-3-8-21(25)9-4-19/h1-4,6-9H,11-17H2
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332620
PNG
(3-(4-bromophenyl)-1-{2-[(4-methoxyphenyl)methyl]-2...)
Show SMILES COc1ccc(CN2CC3(C2)CCN(CC3)C(=O)C#Cc2ccc(Br)cc2)cc1
Show InChI InChI=1S/C24H25BrN2O2/c1-29-22-9-4-20(5-10-22)16-26-17-24(18-26)12-14-27(15-13-24)23(28)11-6-19-2-7-21(25)8-3-19/h2-5,7-10H,12-18H2,1H3
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332611
PNG
(3-(4-bromophenyl)-1-{2-[(4-bromophenyl)carbonyl]-2...)
Show SMILES Brc1ccc(cc1)C#CC(=O)N1CCC2(CN(C2)C(=O)c2ccc(Br)cc2)CC1
Show InChI InChI=1S/C23H20Br2N2O2/c24-19-6-1-17(2-7-19)3-10-21(28)26-13-11-23(12-14-26)15-27(16-23)22(29)18-4-8-20(25)9-5-18/h1-2,4-9H,11-16H2
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332609
PNG
(3-(4-bromophenyl)-1-{7-[(4-chlorophenyl)carbonyl]-...)
Show SMILES Clc1ccc(cc1)C(=O)N1CCC2(CN(C2)C(=O)C#Cc2ccc(Br)cc2)CC1
Show InChI InChI=1S/C23H20BrClN2O2/c24-19-6-1-17(2-7-19)3-10-21(28)27-15-23(16-27)11-13-26(14-12-23)22(29)18-4-8-20(25)9-5-18/h1-2,4-9H,11-16H2
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332571
PNG
((2E)-3-(4-bromophenyl)-1-{7-[(4-chlorophenyl)methy...)
Show SMILES Clc1ccc(CN2CCC3(CN(C3)C(=O)\C=C\c3ccc(Br)cc3)CC2)cc1
Show InChI InChI=1S/C23H24BrClN2O/c24-20-6-1-18(2-7-20)5-10-22(28)27-16-23(17-27)11-13-26(14-12-23)15-19-3-8-21(25)9-4-19/h1-10H,11-17H2/b10-5+
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332610
PNG
(3-(4-bromophenyl)-1-(7-{[4-(trifluoromethyl)phenyl...)
Show SMILES FC(F)(F)c1ccc(cc1)C(=O)N1CCC2(CN(C2)C(=O)C#Cc2ccc(Br)cc2)CC1
Show InChI InChI=1S/C24H20BrF3N2O2/c25-20-8-1-17(2-9-20)3-10-21(31)30-15-23(16-30)11-13-29(14-12-23)22(32)18-4-6-19(7-5-18)24(26,27)28/h1-2,4-9H,11-16H2
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332592
PNG
(5-bromoindol-2-yl 7-[(4-fluorophenyl)carbonyl]-2,7...)
Show SMILES Fc1ccc(cc1)C(=O)N1CCC2(CN(C2)C(=O)c2cc3cc(Br)ccc3[nH]2)CC1
Show InChI InChI=1S/C23H21BrFN3O2/c24-17-3-6-19-16(11-17)12-20(26-19)22(30)28-13-23(14-28)7-9-27(10-8-23)21(29)15-1-4-18(25)5-2-15/h1-6,11-12,26H,7-10,13-14H2
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332631
PNG
(3-(4-fluorophenyl)-1-{2-[(4-fluorophenyl)carbonyl]...)
Show SMILES Fc1ccc(cc1)C#CC(=O)N1CCC2(CN(C2)C(=O)c2ccc(F)cc2)CC1
Show InChI InChI=1S/C23H20F2N2O2/c24-19-6-1-17(2-7-19)3-10-21(28)26-13-11-23(12-14-26)15-27(16-23)22(29)18-4-8-20(25)9-5-18/h1-2,4-9H,11-16H2
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332582
PNG
(4-(2-(5-chloro-1H-indole-2-carbonyl)-2,7-diazaspir...)
Show SMILES OB(O)c1ccc(cc1)C(=O)N1CCC2(CN(C2)C(=O)c2cc3cc(Cl)ccc3[nH]2)CC1
Show InChI InChI=1S/C23H23BClN3O4/c25-18-5-6-19-16(11-18)12-20(26-19)22(30)28-13-23(14-28)7-9-27(10-8-23)21(29)15-1-3-17(4-2-15)24(31)32/h1-6,11-12,26,31-32H,7-10,13-14H2
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332581
PNG
(5-chloroindol-2-yl 7-{[4-(trifluoromethoxy)phenyl]...)
Show SMILES FC(F)(F)Oc1ccc(CN2CCC3(CN(C3)C(=O)c3cc4cc(Cl)ccc4[nH]3)CC2)cc1
Show InChI InChI=1S/C24H23ClF3N3O2/c25-18-3-6-20-17(11-18)12-21(29-20)22(32)31-14-23(15-31)7-9-30(10-8-23)13-16-1-4-19(5-2-16)33-24(26,27)28/h1-6,11-12,29H,7-10,13-15H2
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332577
PNG
((2E)-3-(3,4-dichlorophenyl)-1-{7-[(4-fluorophenyl)...)
Show SMILES Fc1ccc(CN2CCC3(CN(C3)C(=O)\C=C\c3ccc(Cl)c(Cl)c3)CC2)cc1
Show InChI InChI=1S/C23H23Cl2FN2O/c24-20-7-3-17(13-21(20)25)4-8-22(29)28-15-23(16-28)9-11-27(12-10-23)14-18-1-5-19(26)6-2-18/h1-8,13H,9-12,14-16H2/b8-4+
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332560
PNG
(5-chloroindol-2-yl 2-{[4-(trifluoromethyl)phenyl]m...)
Show SMILES FC(F)(F)c1ccc(CN2CC3(C2)CCN(CC3)C(=O)c2cc3cc(Cl)ccc3[nH]2)cc1
Show InChI InChI=1S/C24H23ClF3N3O/c25-19-5-6-20-17(11-19)12-21(29-20)22(32)31-9-7-23(8-10-31)14-30(15-23)13-16-1-3-18(4-2-16)24(26,27)28/h1-6,11-12,29H,7-10,13-15H2
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332644
PNG
(1-{2-[(4-bromophenyl)carbonyl]-2,7-diazaspiro[3.5]...)
Show SMILES Fc1ccc(cc1)C#CC(=O)N1CCC2(CN(C2)C(=O)c2ccc(Br)cc2)CC1
Show InChI InChI=1S/C23H20BrFN2O2/c24-19-6-4-18(5-7-19)22(29)27-15-23(16-27)11-13-26(14-12-23)21(28)10-3-17-1-8-20(25)9-2-17/h1-2,4-9H,11-16H2
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332559
PNG
(5-chloroindol-2-yl 2-{[3-fluoro-4-(trifluoromethyl...)
Show SMILES Fc1cc(CN2CC3(C2)CCN(CC3)C(=O)c2cc3cc(Cl)ccc3[nH]2)ccc1C(F)(F)F
Show InChI InChI=1S/C24H22ClF4N3O/c25-17-2-4-20-16(10-17)11-21(30-20)22(33)32-7-5-23(6-8-32)13-31(14-23)12-15-1-3-18(19(26)9-15)24(27,28)29/h1-4,9-11,30H,5-8,12-14H2
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332572
PNG
((2E)-3-(4-bromophenyl)-1-(7-{[4-fluoro-3-(trifluor...)
Show SMILES Fc1ccc(CN2CCC3(CN(C3)C(=O)\C=C\c3ccc(Br)cc3)CC2)cc1C(F)(F)F
Show InChI InChI=1S/C24H23BrF4N2O/c25-19-5-1-17(2-6-19)4-8-22(32)31-15-23(16-31)9-11-30(12-10-23)14-18-3-7-21(26)20(13-18)24(27,28)29/h1-8,13H,9-12,14-16H2/b8-4+
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332607
PNG
(7-[(3,5-dimethoxyphenyl)methyl]-2,7-diazaspiro[3.5...)
Show SMILES COc1cc(CN2CCC3(CN(C3)C(=O)c3cc4cc(Br)ccc4[nH]3)CC2)cc(OC)c1
Show InChI InChI=1S/C25H28BrN3O3/c1-31-20-9-17(10-21(13-20)32-2)14-28-7-5-25(6-8-28)15-29(16-25)24(30)23-12-18-11-19(26)3-4-22(18)27-23/h3-4,9-13,27H,5-8,14-16H2,1-2H3
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332637
PNG
(3-(4-fluorophenyl)-1-{7-[(4-methoxyphenyl)carbonyl...)
Show SMILES COc1ccc(cc1)C(=O)N1CCC2(CN(C2)C(=O)C#Cc2ccc(F)cc2)CC1
Show InChI InChI=1S/C24H23FN2O3/c1-30-21-9-5-19(6-10-21)23(29)26-14-12-24(13-15-26)16-27(17-24)22(28)11-4-18-2-7-20(25)8-3-18/h2-3,5-10H,12-17H2,1H3
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332642
PNG
(3-(2,4-difluorophenyl)-1-{7-[(4-methoxyphenyl)carb...)
Show SMILES COc1ccc(cc1)C(=O)N1CCC2(CN(C2)C(=O)C#Cc2ccc(F)cc2F)CC1
Show InChI InChI=1S/C24H22F2N2O3/c1-31-20-7-3-18(4-8-20)23(30)27-12-10-24(11-13-27)15-28(16-24)22(29)9-5-17-2-6-19(25)14-21(17)26/h2-4,6-8,14H,10-13,15-16H2,1H3
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332643
PNG
(3-(2H-benzo[3,4-d]1,3-dioxolen-5-yl)-1-{2-[(4-chlo...)
Show SMILES Clc1ccc(cc1)C(=O)N1CC2(C1)CCN(CC2)C(=O)C#Cc1ccc2OCOc2c1
Show InChI InChI=1S/C24H21ClN2O4/c25-19-5-3-18(4-6-19)23(29)27-14-24(15-27)9-11-26(12-10-24)22(28)8-2-17-1-7-20-21(13-17)31-16-30-20/h1,3-7,13H,9-12,14-16H2
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332634
PNG
(3-(4-fluorophenyl)-1-{2-[(4-methoxyphenyl)carbonyl...)
Show SMILES COc1ccc(cc1)C(=O)N1CC2(C1)CCN(CC2)C(=O)C#Cc1ccc(F)cc1
Show InChI InChI=1S/C24H23FN2O3/c1-30-21-9-5-19(6-10-21)23(29)27-16-24(17-27)12-14-26(15-13-24)22(28)11-4-18-2-7-20(25)8-3-18/h2-3,5-10H,12-17H2,1H3
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332638
PNG
(3-(4-fluorophenyl)-1-{7-[(4-fluorophenyl)carbonyl]...)
Show SMILES Fc1ccc(cc1)C#CC(=O)N1CC2(C1)CCN(CC2)C(=O)c1ccc(F)cc1
Show InChI InChI=1S/C23H20F2N2O2/c24-19-6-1-17(2-7-19)3-10-21(28)27-15-23(16-27)11-13-26(14-12-23)22(29)18-4-8-20(25)9-5-18/h1-2,4-9H,11-16H2
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332605
PNG
(5-bromoindol-2-yl 7-{[4-fluoro-2-(trifluoromethyl)...)
Show SMILES Fc1ccc(CN2CCC3(CN(C3)C(=O)c3cc4cc(Br)ccc4[nH]3)CC2)c(c1)C(F)(F)F
Show InChI InChI=1S/C24H22BrF4N3O/c25-17-2-4-20-16(9-17)10-21(30-20)22(33)32-13-23(14-32)5-7-31(8-6-23)12-15-1-3-18(26)11-19(15)24(27,28)29/h1-4,9-11,30H,5-8,12-14H2
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n/an/a 35n/an/an/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332594
PNG
(5-bromoindol-2-yl 7-[(4-chlorophenyl)methyl]-2,7-d...)
Show SMILES Clc1ccc(CN2CCC3(CN(C3)C(=O)c3cc4cc(Br)ccc4[nH]3)CC2)cc1
Show InChI InChI=1S/C23H23BrClN3O/c24-18-3-6-20-17(11-18)12-21(26-20)22(29)28-14-23(15-28)7-9-27(10-8-23)13-16-1-4-19(25)5-2-16/h1-6,11-12,26H,7-10,13-15H2
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332647
PNG
(US10196369, Compound H1 | tert-butyl 7-(3-(benzo[d...)
Show SMILES CC(C)(C)OC(=O)N1CC2(C1)CCN(CC2)C(=O)C#Cc1ccc2OCOc2c1
Show InChI InChI=1S/C22H26N2O5/c1-21(2,3)29-20(26)24-13-22(14-24)8-10-23(11-9-22)19(25)7-5-16-4-6-17-18(12-16)28-15-27-17/h4,6,12H,8-11,13-15H2,1-3H3
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332595
PNG
(5-bromoindol-2-yl 7-{[4-(trifluoromethyl)phenyl]me...)
Show SMILES FC(F)(F)c1ccc(CN2CCC3(CN(C3)C(=O)c3cc4cc(Br)ccc4[nH]3)CC2)cc1
Show InChI InChI=1S/C24H23BrF3N3O/c25-19-5-6-20-17(11-19)12-21(29-20)22(32)31-14-23(15-31)7-9-30(10-8-23)13-16-1-3-18(4-2-16)24(26,27)28/h1-6,11-12,29H,7-10,13-15H2
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n/an/a 35n/an/an/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332608
PNG
(6-bromoindol-2-yl 7-{[4-(trifluoromethyl)phenyl]me...)
Show SMILES FC(F)(F)c1ccc(CN2CCC3(CN(C3)C(=O)c3cc4ccc(Br)cc4[nH]3)CC2)cc1
Show InChI InChI=1S/C24H23BrF3N3O/c25-19-6-3-17-11-21(29-20(17)12-19)22(32)31-14-23(15-31)7-9-30(10-8-23)13-16-1-4-18(5-2-16)24(26,27)28/h1-6,11-12,29H,7-10,13-15H2
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332604
PNG
(6-bromoindol-2-yl 7-[(4-chlorophenyl)carbonyl]-2,7...)
Show SMILES Clc1ccc(cc1)C(=O)N1CCC2(CN(C2)C(=O)c2cc3ccc(Br)cc3[nH]2)CC1
Show InChI InChI=1S/C23H21BrClN3O2/c24-17-4-1-16-11-20(26-19(16)12-17)22(30)28-13-23(14-28)7-9-27(10-8-23)21(29)15-2-5-18(25)6-3-15/h1-6,11-12,26H,7-10,13-14H2
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332602
PNG
(6-bromoindol-2-yl 7-[(4-fluorophenyl)carbonyl]-2,7...)
Show SMILES Fc1ccc(cc1)C(=O)N1CCC2(CN(C2)C(=O)c2cc3ccc(Br)cc3[nH]2)CC1
Show InChI InChI=1S/C23H21BrFN3O2/c24-17-4-1-16-11-20(26-19(16)12-17)22(30)28-13-23(14-28)7-9-27(10-8-23)21(29)15-2-5-18(25)6-3-15/h1-6,11-12,26H,7-10,13-14H2
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n/an/a 35n/an/an/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332600
PNG
(6-chloroindol-2-yl 7-[(4-fluorophenyl)carbonyl]-2,...)
Show SMILES Fc1ccc(cc1)C(=O)N1CCC2(CN(C2)C(=O)c2cc3ccc(Cl)cc3[nH]2)CC1
Show InChI InChI=1S/C23H21ClFN3O2/c24-17-4-1-16-11-20(26-19(16)12-17)22(30)28-13-23(14-28)7-9-27(10-8-23)21(29)15-2-5-18(25)6-3-15/h1-6,11-12,26H,7-10,13-14H2
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n/an/a 35n/an/an/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332603
PNG
(6-bromoindol-2-yl 7-{[4-(trifluoromethyl)phenyl]ca...)
Show SMILES FC(F)(F)c1ccc(cc1)C(=O)N1CCC2(CN(C2)C(=O)c2cc3ccc(Br)cc3[nH]2)CC1
Show InChI InChI=1S/C24H21BrF3N3O2/c25-18-6-3-16-11-20(29-19(16)12-18)22(33)31-13-23(14-31)7-9-30(10-8-23)21(32)15-1-4-17(5-2-15)24(26,27)28/h1-6,11-12,29H,7-10,13-14H2
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332628
PNG
(3-(4-chlorophenyl)-1-(7-{[4-(trifluoromethyl)pheny...)
Show SMILES FC(F)(F)c1ccc(CN2CCC3(CN(C3)C(=O)C#Cc3ccc(Cl)cc3)CC2)cc1
Show InChI InChI=1S/C24H22ClF3N2O/c25-21-8-3-18(4-9-21)5-10-22(31)30-16-23(17-30)11-13-29(14-12-23)15-19-1-6-20(7-2-19)24(26,27)28/h1-4,6-9H,11-17H2
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332601
PNG
(6-chloroindol-2-yl 7-[(4-chlorophenyl)carbonyl]-2,...)
Show SMILES Clc1ccc(cc1)C(=O)N1CCC2(CN(C2)C(=O)c2cc3ccc(Cl)cc3[nH]2)CC1
Show InChI InChI=1S/C23H21Cl2N3O2/c24-17-4-1-15(2-5-17)21(29)27-9-7-23(8-10-27)13-28(14-23)22(30)20-11-16-3-6-18(25)12-19(16)26-20/h1-6,11-12,26H,7-10,13-14H2
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332582
PNG
(4-(2-(5-chloro-1H-indole-2-carbonyl)-2,7-diazaspir...)
Show SMILES OB(O)c1ccc(cc1)C(=O)N1CCC2(CN(C2)C(=O)c2cc3cc(Cl)ccc3[nH]2)CC1
Show InChI InChI=1S/C23H23BClN3O4/c25-18-5-6-19-16(11-18)12-20(26-19)22(30)28-13-23(14-28)7-9-27(10-8-23)21(29)15-1-3-17(4-2-15)24(31)32/h1-6,11-12,26,31-32H,7-10,13-14H2
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332587
PNG
(5-chloroindol-2-yl 7-[(4-(1H-1,2,3,4-tetraazol-5-y...)
Show SMILES Clc1ccc2[nH]c(cc2c1)C(=O)N1CC2(C1)CCN(CC2)C(=O)c1ccc(cc1)-c1nnn[nH]1
Show InChI InChI=1S/C24H22ClN7O2/c25-18-5-6-19-17(11-18)12-20(26-19)23(34)32-13-24(14-32)7-9-31(10-8-24)22(33)16-3-1-15(2-4-16)21-27-29-30-28-21/h1-6,11-12,26H,7-10,13-14H2,(H,27,28,29,30)
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332561
PNG
(5-chloroindol-2-yl 2-[(4-(1H-1,2,3,4-tetraazol-5-y...)
Show SMILES Clc1ccc2[nH]c(cc2c1)C(=O)N1CCC2(CN(C2)C(=O)c2ccc(cc2)-c2nnn[nH]2)CC1
Show InChI InChI=1S/C24H22ClN7O2/c25-18-5-6-19-17(11-18)12-20(26-19)23(34)31-9-7-24(8-10-31)13-32(14-24)22(33)16-3-1-15(2-4-16)21-27-29-30-28-21/h1-6,11-12,26H,7-10,13-14H2,(H,27,28,29,30)
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332612
PNG
(3-(4-bromophenyl)-1-{2-[(4-fluorophenyl)carbonyl]-...)
Show SMILES Fc1ccc(cc1)C(=O)N1CC2(C1)CCN(CC2)C(=O)C#Cc1ccc(Br)cc1
Show InChI InChI=1S/C23H20BrFN2O2/c24-19-6-1-17(2-7-19)3-10-21(28)26-13-11-23(12-14-26)15-27(16-23)22(29)18-4-8-20(25)9-5-18/h1-2,4-9H,11-16H2
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332576
PNG
((2E)-3-(3,4-dichlorophenyl)-1-{7-[(4-(1H-1,2,3,4-t...)
Show SMILES Clc1ccc(\C=C\C(=O)N2CC3(C2)CCN(CC3)C(=O)c2ccc(cc2)-c2nnn[nH]2)cc1Cl
Show InChI InChI=1S/C24H22Cl2N6O2/c25-19-7-1-16(13-20(19)26)2-8-21(33)32-14-24(15-32)9-11-31(12-10-24)23(34)18-5-3-17(4-6-18)22-27-29-30-28-22/h1-8,13H,9-12,14-15H2,(H,27,28,29,30)/b8-2+
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n/an/a 35n/an/an/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%