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Patent code US10196374

Compile Data Set for Download or QSAR
Found 50 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM332676
PNG
(US10196374, Example 4)
Show SMILES CC(C)[C@H](NC(=O)C(F)(F)F)[C@H](Oc1ccc2n(ncc2c1)-c1ccc(=O)n(C)c1)c1cc(F)cc(F)c1
Show InChI InChI=1S/C26H23F5N4O3/c1-14(2)23(33-25(37)26(29,30)31)24(15-8-17(27)11-18(28)9-15)38-20-5-6-21-16(10-20)12-32-35(21)19-4-7-22(36)34(3)13-19/h4-14,23-24H,1-3H3,(H,33,37)/t23-,24+/m0/s1
PDB

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US Patent
n/an/a 1.58n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A reporter cell line (ChagoK1 18:7:2 s4/GRE) was established by stable transfection of the human bronchogenic carcinoma celline, ChaGo K1 (ATCC: HTB ...


US Patent US10196374 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM332690
PNG
(US10196374, Example 18)
Show SMILES CC(C)[C@H](NC(=O)C(F)(F)F)[C@H](Oc1ccc2n(ncc2c1)-c1ccc(=O)n(C)c1)c1cc(F)cc(Cl)c1
Show InChI InChI=1S/C26H23ClF4N4O3/c1-14(2)23(33-25(37)26(29,30)31)24(15-8-17(27)11-18(28)9-15)38-20-5-6-21-16(10-20)12-32-35(21)19-4-7-22(36)34(3)13-19/h4-14,23-24H,1-3H3,(H,33,37)/t23-,24+/m0/s1
PDB

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n/an/a 25.1n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A reporter cell line (ChagoK1 18:7:2 s4/GRE) was established by stable transfection of the human bronchogenic carcinoma celline, ChaGo K1 (ATCC: HTB ...


US Patent US10196374 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM332669
PNG
(US10196374, Example 3)
Show SMILES CC(C)[C@H](NC(=O)C(C)(F)F)[C@H](Oc1ccc2n(ncc2c1)-c1ccc(=O)n(C)c1)c1cc(F)cc(F)c1
Show InChI InChI=1S/C27H26F4N4O3/c1-15(2)24(33-26(37)27(3,30)31)25(16-9-18(28)12-19(29)10-16)38-21-6-7-22-17(11-21)13-32-35(22)20-5-8-23(36)34(4)14-20/h5-15,24-25H,1-4H3,(H,33,37)/t24-,25+/m0/s1
PDB

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n/an/a 25.1n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A reporter cell line (ChagoK1 18:7:2 s4/GRE) was established by stable transfection of the human bronchogenic carcinoma celline, ChaGo K1 (ATCC: HTB ...


US Patent US10196374 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM332691
PNG
(US10196374, Example 19)
Show SMILES CC(C)[C@H](NC(=O)C(C)(F)F)[C@H](Oc1ccc2n(ncc2c1)-c1ccc(=O)n(C)c1)c1cc(F)cc(Cl)c1
Show InChI InChI=1S/C27H26ClF3N4O3/c1-15(2)24(33-26(37)27(3,30)31)25(16-9-18(28)12-19(29)10-16)38-21-6-7-22-17(11-21)13-32-35(22)20-5-8-23(36)34(4)14-20/h5-15,24-25H,1-4H3,(H,33,37)/t24-,25+/m0/s1
PDB

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n/an/a 25.1n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A reporter cell line (ChagoK1 18:7:2 s4/GRE) was established by stable transfection of the human bronchogenic carcinoma celline, ChaGo K1 (ATCC: HTB ...


US Patent US10196374 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM332689
PNG
(US10196374, Example 17)
Show SMILES CC(C)[C@H](NC(=O)C(F)(F)F)[C@H](Oc1ccc2n(ncc2c1)-c1ccc(=O)n(C)c1)c1ccc(Cl)c(F)c1
Show InChI InChI=1S/C26H23ClF4N4O3/c1-14(2)23(33-25(37)26(29,30)31)24(15-4-7-19(27)20(28)11-15)38-18-6-8-21-16(10-18)12-32-35(21)17-5-9-22(36)34(3)13-17/h4-14,23-24H,1-3H3,(H,33,37)/t23-,24+/m0/s1
PDB

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n/an/a 39.8n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A reporter cell line (ChagoK1 18:7:2 s4/GRE) was established by stable transfection of the human bronchogenic carcinoma celline, ChaGo K1 (ATCC: HTB ...


US Patent US10196374 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM332692
PNG
(US10196374, Example 20)
Show SMILES CC(C)[C@H](NC(=O)C(C)(F)F)[C@H](Oc1ccc2n(ncc2c1)-c1ccc(=O)n(C)c1)c1ccc(Cl)c(F)c1
Show InChI InChI=1S/C27H26ClF3N4O3/c1-15(2)24(33-26(37)27(3,30)31)25(16-5-8-20(28)21(29)12-16)38-19-7-9-22-17(11-19)13-32-35(22)18-6-10-23(36)34(4)14-18/h5-15,24-25H,1-4H3,(H,33,37)/t24-,25+/m0/s1
PDB

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n/an/a 50.1n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A reporter cell line (ChagoK1 18:7:2 s4/GRE) was established by stable transfection of the human bronchogenic carcinoma celline, ChaGo K1 (ATCC: HTB ...


US Patent US10196374 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM332696
PNG
(US10196374, Example 22)
Show SMILES CC(C)[C@H](NC(=O)C(F)(F)F)[C@H](Oc1cc2cnn(-c3ccc(=O)n(C)c3)c2cc1Cl)c1ccccc1
Show InChI InChI=1S/C26H24ClF3N4O3/c1-15(2)23(32-25(36)26(28,29)30)24(16-7-5-4-6-8-16)37-21-11-17-13-31-34(20(17)12-19(21)27)18-9-10-22(35)33(3)14-18/h4-15,23-24H,1-3H3,(H,32,36)/t23-,24+/m0/s1
PDB

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AstraZeneca AB

US Patent


Assay Description
A reporter cell line (ChagoK1 18:7:2 s4/GRE) was established by stable transfection of the human bronchogenic carcinoma celline, ChaGo K1 (ATCC: HTB ...


US Patent US10196374 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM332693
PNG
(US10196374, Example 21)
Show SMILES CC(C)[C@H](NC(=O)C(C)(F)F)[C@H](Oc1cc2cnn(-c3ccc(=O)n(C)c3)c2cc1Cl)c1ccccc1
Show InChI InChI=1S/C27H27ClF2N4O3/c1-16(2)24(32-26(36)27(3,29)30)25(17-8-6-5-7-9-17)37-22-12-18-14-31-34(21(18)13-20(22)28)19-10-11-23(35)33(4)15-19/h5-16,24-25H,1-4H3,(H,32,36)/t24-,25+/m0/s1
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AstraZeneca AB

US Patent


Assay Description
A reporter cell line (ChagoK1 18:7:2 s4/GRE) was established by stable transfection of the human bronchogenic carcinoma celline, ChaGo K1 (ATCC: HTB ...


US Patent US10196374 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM332687
PNG
(US10196374, Example 15)
Show SMILES CC(C)[C@H](NC(=O)C(F)(F)F)[C@H](Oc1ccc2n(ncc2c1)-c1ccc(=O)n(C)c1)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C27H24F6N4O3/c1-15(2)23(35-25(39)27(31,32)33)24(16-4-6-18(7-5-16)26(28,29)30)40-20-9-10-21-17(12-20)13-34-37(21)19-8-11-22(38)36(3)14-19/h4-15,23-24H,1-3H3,(H,35,39)/t23-,24+/m0/s1
PDB

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AstraZeneca AB

US Patent


Assay Description
A reporter cell line (ChagoK1 18:7:2 s4/GRE) was established by stable transfection of the human bronchogenic carcinoma celline, ChaGo K1 (ATCC: HTB ...


US Patent US10196374 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM332678
PNG
(US10196374, Example 6)
Show SMILES CC(C)[C@H](NC(=O)C(F)(F)F)[C@H](Oc1ccc2n(ncc2c1)-c1ccc(=O)n(C)c1)c1cccc(Cl)c1
Show InChI InChI=1S/C26H24ClF3N4O3/c1-15(2)23(32-25(36)26(28,29)30)24(16-5-4-6-18(27)11-16)37-20-8-9-21-17(12-20)13-31-34(21)19-7-10-22(35)33(3)14-19/h4-15,23-24H,1-3H3,(H,32,36)/t23-,24+/m0/s1
PDB

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AstraZeneca AB

US Patent


Assay Description
A reporter cell line (ChagoK1 18:7:2 s4/GRE) was established by stable transfection of the human bronchogenic carcinoma celline, ChaGo K1 (ATCC: HTB ...


US Patent US10196374 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM332684
PNG
(US10196374, Example 12)
Show SMILES CC(C)[C@H](NC(=O)C(C)(F)F)[C@H](Oc1cc2cnn(-c3ccc(=O)n(C)c3)c2cc1C)c1ccccc1
Show InChI InChI=1S/C28H30F2N4O3/c1-17(2)25(32-27(36)28(4,29)30)26(19-9-7-6-8-10-19)37-23-14-20-15-31-34(22(20)13-18(23)3)21-11-12-24(35)33(5)16-21/h6-17,25-26H,1-5H3,(H,32,36)/t25-,26+/m0/s1
PDB

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AstraZeneca AB

US Patent


Assay Description
A reporter cell line (ChagoK1 18:7:2 s4/GRE) was established by stable transfection of the human bronchogenic carcinoma celline, ChaGo K1 (ATCC: HTB ...


US Patent US10196374 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM332679
PNG
(US10196374, Example 7)
Show SMILES CC(C)[C@H](NC(=O)C(C)(F)F)[C@H](Oc1ccc2n(ncc2c1)-c1ccc(=O)n(C)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C27H27ClF2N4O3/c1-16(2)24(32-26(36)27(3,29)30)25(17-5-7-19(28)8-6-17)37-21-10-11-22-18(13-21)14-31-34(22)20-9-12-23(35)33(4)15-20/h5-16,24-25H,1-4H3,(H,32,36)/t24-,25+/m0/s1
PDB

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AstraZeneca AB

US Patent


Assay Description
A reporter cell line (ChagoK1 18:7:2 s4/GRE) was established by stable transfection of the human bronchogenic carcinoma celline, ChaGo K1 (ATCC: HTB ...


US Patent US10196374 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM332661
PNG
(Preparation of 2,2,2-trifluoro-N-[(1R,2S)-3-methyl...)
Show SMILES CC(C)[C@H](NC(=O)C(F)(F)F)[C@H](Oc1ccc2n(ncc2c1)-c1ccc(=O)n(C)c1)c1ccccc1
Show InChI InChI=1S/C26H25F3N4O3/c1-16(2)23(31-25(35)26(27,28)29)24(17-7-5-4-6-8-17)36-20-10-11-21-18(13-20)14-30-33(21)19-9-12-22(34)32(3)15-19/h4-16,23-24H,1-3H3,(H,31,35)/t23-,24+/m0/s1
PDB

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AstraZeneca AB

US Patent


Assay Description
A reporter cell line (ChagoK1 18:7:2 s4/GRE) was established by stable transfection of the human bronchogenic carcinoma celline, ChaGo K1 (ATCC: HTB ...


US Patent US10196374 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM332682
PNG
(US10196374, Example 10)
Show SMILES CC(C)[C@H](NC(=O)C(C)(F)F)[C@H](Oc1ccc2n(ncc2c1)C1=C[N](C)=[C](=O)C=C1)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C28H27F5N4O3/c1-16(2)24(35-26(39)27(3,29)30)25(17-5-7-19(8-6-17)28(31,32)33)40-21-10-11-22-18(13-21)14-34-37(22)20-9-12-23(38)36(4)15-20/h5-16,24-25H,1-4H3,(H,35,39)/t24-,25+/m0/s1
PDB

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AstraZeneca AB

US Patent


Assay Description
A reporter cell line (ChagoK1 18:7:2 s4/GRE) was established by stable transfection of the human bronchogenic carcinoma celline, ChaGo K1 (ATCC: HTB ...


US Patent US10196374 (2019)

More data for this
Ligand-Target Pair
Tumor necrosis factor


(Homo sapiens (Human))
BDBM332669
PNG
(US10196374, Example 3)
Show SMILES CC(C)[C@H](NC(=O)C(C)(F)F)[C@H](Oc1ccc2n(ncc2c1)-c1ccc(=O)n(C)c1)c1cc(F)cc(F)c1
Show InChI InChI=1S/C27H26F4N4O3/c1-15(2)24(33-26(37)27(3,30)31)25(16-9-18(28)12-19(29)10-16)38-21-6-7-22-17(11-21)13-32-35(22)20-5-8-23(36)34(4)14-20/h5-15,24-25H,1-4H3,(H,33,37)/t24-,25+/m0/s1
PDB
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AstraZeneca AB

US Patent


Assay Description
TNFα protein levels were determined using an AlphaLISA hTNFa kit (Perkin Elmer) according to the manufacturer's instructions. Briefly, the s...


US Patent US10196374 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM332685
PNG
(US10196374, Example 13)
Show SMILES CC(C)[C@H](NC(=O)C(F)(F)F)[C@H](Oc1ccc2n(ncc2c1)-c1ccc(=O)n(C)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C26H24ClF3N4O3/c1-15(2)23(32-25(36)26(28,29)30)24(16-4-6-18(27)7-5-16)37-20-9-10-21-17(12-20)13-31-34(21)19-8-11-22(35)33(3)14-19/h4-15,23-24H,1-3H3,(H,32,36)/t23-,24+/m0/s1
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AstraZeneca AB

US Patent


Assay Description
A reporter cell line (ChagoK1 18:7:2 s4/GRE) was established by stable transfection of the human bronchogenic carcinoma celline, ChaGo K1 (ATCC: HTB ...


US Patent US10196374 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM332681
PNG
(US10196374, Example 9)
Show SMILES CC(C)[C@H](NC(=O)C(C)(F)F)[C@H](Oc1ccc2n(ncc2c1)-c1ccc(=O)n(C)c1)c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C28H27F5N4O4/c1-16(2)24(35-26(39)27(3,29)30)25(17-5-8-20(9-6-17)41-28(31,32)33)40-21-10-11-22-18(13-21)14-34-37(22)19-7-12-23(38)36(4)15-19/h5-16,24-25H,1-4H3,(H,35,39)/t24-,25+/m0/s1
PDB

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AstraZeneca AB

US Patent


Assay Description
A reporter cell line (ChagoK1 18:7:2 s4/GRE) was established by stable transfection of the human bronchogenic carcinoma celline, ChaGo K1 (ATCC: HTB ...


US Patent US10196374 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM332686
PNG
(US10196374, Example 14)
Show SMILES CC(C)[C@H](NC(=O)C(F)(F)F)[C@H](Oc1ccc2n(ncc2c1)-c1ccc(=O)n(C)c1)c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C26H23Cl2F3N4O3/c1-14(2)23(33-25(37)26(29,30)31)24(15-8-17(27)11-18(28)9-15)38-20-5-6-21-16(10-20)12-32-35(21)19-4-7-22(36)34(3)13-19/h4-14,23-24H,1-3H3,(H,33,37)/t23-,24+/m0/s1
PDB

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n/an/a 126n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A reporter cell line (ChagoK1 18:7:2 s4/GRE) was established by stable transfection of the human bronchogenic carcinoma celline, ChaGo K1 (ATCC: HTB ...


US Patent US10196374 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM332659
PNG
(US10196374, Example 1)
Show SMILES CC(C)[C@H](NC(=O)C(C)(F)F)[C@H](Oc1ccc2n(ncc2c1)-c1ccc(=O)n(C)c1)c1ccccc1
Show InChI InChI=1S/C27H28F2N4O3/c1-17(2)24(31-26(35)27(3,28)29)25(18-8-6-5-7-9-18)36-21-11-12-22-19(14-21)15-30-33(22)20-10-13-23(34)32(4)16-20/h5-17,24-25H,1-4H3,(H,31,35)/t24-,25+/m0/s1
PDB

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n/an/a 158n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A reporter cell line (ChagoK1 18:7:2 s4/GRE) was established by stable transfection of the human bronchogenic carcinoma celline, ChaGo K1 (ATCC: HTB ...


US Patent US10196374 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM332680
PNG
(US10196374, Example 8)
Show SMILES CC(C)[C@H](NC(=O)C(C)(F)F)[C@H](Oc1ccc2n(ncc2c1)-c1ccc(=O)n(C)c1)c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C27H26Cl2F2N4O3/c1-15(2)24(33-26(37)27(3,30)31)25(16-9-18(28)12-19(29)10-16)38-21-6-7-22-17(11-21)13-32-35(22)20-5-8-23(36)34(4)14-20/h5-15,24-25H,1-4H3,(H,33,37)/t24-,25+/m0/s1
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n/an/a 158n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A reporter cell line (ChagoK1 18:7:2 s4/GRE) was established by stable transfection of the human bronchogenic carcinoma celline, ChaGo K1 (ATCC: HTB ...


US Patent US10196374 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM332677
PNG
(US10196374, Example 5)
Show SMILES CC(C)[C@H](NC(=O)C(C)(F)F)[C@H](Oc1ccc2n(ncc2c1)-c1ccc(=O)n(C)c1)c1cccc(Cl)c1
Show InChI InChI=1S/C27H27ClF2N4O3/c1-16(2)24(32-26(36)27(3,29)30)25(17-6-5-7-19(28)12-17)37-21-9-10-22-18(13-21)14-31-34(22)20-8-11-23(35)33(4)15-20/h5-16,24-25H,1-4H3,(H,32,36)/t24-,25+/m0/s1
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AstraZeneca AB

US Patent


Assay Description
A reporter cell line (ChagoK1 18:7:2 s4/GRE) was established by stable transfection of the human bronchogenic carcinoma celline, ChaGo K1 (ATCC: HTB ...


US Patent US10196374 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM332683
PNG
(US10196374, Example 11)
Show SMILES CC(C)[C@H](NC(=O)C(C)(F)F)[C@H](Oc1ccc2n(ncc2c1)C1=C[N](C)=[C](=O)C=C1)c1ccc(OC(F)F)cc1
Show InChI InChI=1S/C28H28F4N4O4/c1-16(2)24(34-26(38)28(3,31)32)25(17-5-8-20(9-6-17)40-27(29)30)39-21-10-11-22-18(13-21)14-33-36(22)19-7-12-23(37)35(4)15-19/h5-16,24-25,27H,1-4H3,(H,34,38)/t24-,25+/m0/s1
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AstraZeneca AB

US Patent


Assay Description
A reporter cell line (ChagoK1 18:7:2 s4/GRE) was established by stable transfection of the human bronchogenic carcinoma celline, ChaGo K1 (ATCC: HTB ...


US Patent US10196374 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM332688
PNG
(US10196374, Example 16)
Show SMILES CC(C)[C@H](NC(=O)C(F)(F)F)[C@H](Oc1ccc2n(ncc2c1)-c1ccc(=O)n(C)c1)c1ccc(OC(F)F)cc1
Show InChI InChI=1S/C27H25F5N4O4/c1-15(2)23(34-25(38)27(30,31)32)24(16-4-7-19(8-5-16)40-26(28)29)39-20-9-10-21-17(12-20)13-33-36(21)18-6-11-22(37)35(3)14-18/h4-15,23-24,26H,1-3H3,(H,34,38)/t23-,24+/m0/s1
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AstraZeneca AB

US Patent


Assay Description
A reporter cell line (ChagoK1 18:7:2 s4/GRE) was established by stable transfection of the human bronchogenic carcinoma celline, ChaGo K1 (ATCC: HTB ...


US Patent US10196374 (2019)

More data for this
Ligand-Target Pair
Tumor necrosis factor


(Homo sapiens (Human))
BDBM19190
PNG
((1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-...)
Show SMILES C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)C=C[C@]34C)[C@@H]1CC[C@]2(O)C(=O)CO
Show InChI InChI=1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-16,18,22,24,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
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US Patent
n/an/a 251n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
TNFα protein levels were determined using an AlphaLISA hTNFa kit (Perkin Elmer) according to the manufacturer's instructions. Briefly, the s...


US Patent US10196374 (2019)

More data for this
Ligand-Target Pair
Tumor necrosis factor


(Homo sapiens (Human))
BDBM332678
PNG
(US10196374, Example 6)
Show SMILES CC(C)[C@H](NC(=O)C(F)(F)F)[C@H](Oc1ccc2n(ncc2c1)-c1ccc(=O)n(C)c1)c1cccc(Cl)c1
Show InChI InChI=1S/C26H24ClF3N4O3/c1-15(2)23(32-25(36)26(28,29)30)24(16-5-4-6-18(27)11-16)37-20-8-9-21-17(12-20)13-31-34(21)19-7-10-22(35)33(3)14-19/h4-15,23-24H,1-3H3,(H,32,36)/t23-,24+/m0/s1
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AstraZeneca AB

US Patent


Assay Description
TNFα protein levels were determined using an AlphaLISA hTNFa kit (Perkin Elmer) according to the manufacturer's instructions. Briefly, the s...


US Patent US10196374 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM332697
PNG
(US10196374, Example 23)
Show SMILES CCn1cc(ccc1=O)-n1ncc2cc(O[C@@H]([C@@H](NC(=O)C(C)(F)F)C(C)C)c3ccccc3)ccc12
Show InChI InChI=1S/C28H30F2N4O3/c1-5-33-17-21(11-14-24(33)35)34-23-13-12-22(15-20(23)16-31-34)37-26(19-9-7-6-8-10-19)25(18(2)3)32-27(36)28(4,29)30/h6-18,25-26H,5H2,1-4H3,(H,32,36)/t25-,26+/m0/s1
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AstraZeneca AB

US Patent


Assay Description
A reporter cell line (ChagoK1 18:7:2 s4/GRE) was established by stable transfection of the human bronchogenic carcinoma celline, ChaGo K1 (ATCC: HTB ...


US Patent US10196374 (2019)

More data for this
Ligand-Target Pair
Tumor necrosis factor


(Homo sapiens (Human))
BDBM332659
PNG
(US10196374, Example 1)
Show SMILES CC(C)[C@H](NC(=O)C(C)(F)F)[C@H](Oc1ccc2n(ncc2c1)-c1ccc(=O)n(C)c1)c1ccccc1
Show InChI InChI=1S/C27H28F2N4O3/c1-17(2)24(31-26(35)27(3,28)29)25(18-8-6-5-7-9-18)36-21-11-12-22-19(14-21)15-30-33(22)20-10-13-23(34)32(4)16-20/h5-17,24-25H,1-4H3,(H,31,35)/t24-,25+/m0/s1
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AstraZeneca AB

US Patent


Assay Description
TNFα protein levels were determined using an AlphaLISA hTNFa kit (Perkin Elmer) according to the manufacturer's instructions. Briefly, the s...


US Patent US10196374 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM332690
PNG
(US10196374, Example 18)
Show SMILES CC(C)[C@H](NC(=O)C(F)(F)F)[C@H](Oc1ccc2n(ncc2c1)-c1ccc(=O)n(C)c1)c1cc(F)cc(Cl)c1
Show InChI InChI=1S/C26H23ClF4N4O3/c1-14(2)23(33-25(37)26(29,30)31)24(15-8-17(27)11-18(28)9-15)38-20-5-6-21-16(10-20)12-32-35(21)19-4-7-22(36)34(3)13-19/h4-14,23-24H,1-3H3,(H,33,37)/t23-,24+/m0/s1
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AstraZeneca AB

US Patent


Assay Description
A reporter cell line (ChagoK1 18:7:2 s4/GRE) was established by stable transfection of the human bronchogenic carcinoma cell line, ChaGo K1 (ATCC: HT...


US Patent US10196374 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM332688
PNG
(US10196374, Example 16)
Show SMILES CC(C)[C@H](NC(=O)C(F)(F)F)[C@H](Oc1ccc2n(ncc2c1)-c1ccc(=O)n(C)c1)c1ccc(OC(F)F)cc1
Show InChI InChI=1S/C27H25F5N4O4/c1-15(2)23(34-25(38)27(30,31)32)24(16-4-7-19(8-5-16)40-26(28)29)39-20-9-10-21-17(12-20)13-33-36(21)18-6-11-22(37)35(3)14-18/h4-15,23-24,26H,1-3H3,(H,34,38)/t23-,24+/m0/s1
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AstraZeneca AB

US Patent


Assay Description
A reporter cell line (ChagoK1 18:7:2 s4/GRE) was established by stable transfection of the human bronchogenic carcinoma cell line, ChaGo K1 (ATCC: HT...


US Patent US10196374 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM332687
PNG
(US10196374, Example 15)
Show SMILES CC(C)[C@H](NC(=O)C(F)(F)F)[C@H](Oc1ccc2n(ncc2c1)-c1ccc(=O)n(C)c1)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C27H24F6N4O3/c1-15(2)23(35-25(39)27(31,32)33)24(16-4-6-18(7-5-16)26(28,29)30)40-20-9-10-21-17(12-20)13-34-37(21)19-8-11-22(38)36(3)14-19/h4-15,23-24H,1-3H3,(H,35,39)/t23-,24+/m0/s1
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AstraZeneca AB

US Patent


Assay Description
A reporter cell line (ChagoK1 18:7:2 s4/GRE) was established by stable transfection of the human bronchogenic carcinoma cell line, ChaGo K1 (ATCC: HT...


US Patent US10196374 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM332684
PNG
(US10196374, Example 12)
Show SMILES CC(C)[C@H](NC(=O)C(C)(F)F)[C@H](Oc1cc2cnn(-c3ccc(=O)n(C)c3)c2cc1C)c1ccccc1
Show InChI InChI=1S/C28H30F2N4O3/c1-17(2)25(32-27(36)28(4,29)30)26(19-9-7-6-8-10-19)37-23-14-20-15-31-34(22(20)13-18(23)3)21-11-12-24(35)33(5)16-21/h6-17,25-26H,1-5H3,(H,32,36)/t25-,26+/m0/s1
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AstraZeneca AB

US Patent


Assay Description
A reporter cell line (ChagoK1 18:7:2 s4/GRE) was established by stable transfection of the human bronchogenic carcinoma cell line, ChaGo K1 (ATCC: HT...


US Patent US10196374 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM332659
PNG
(US10196374, Example 1)
Show SMILES CC(C)[C@H](NC(=O)C(C)(F)F)[C@H](Oc1ccc2n(ncc2c1)-c1ccc(=O)n(C)c1)c1ccccc1
Show InChI InChI=1S/C27H28F2N4O3/c1-17(2)24(31-26(35)27(3,28)29)25(18-8-6-5-7-9-18)36-21-11-12-22-19(14-21)15-30-33(22)20-10-13-23(34)32(4)16-20/h5-17,24-25H,1-4H3,(H,31,35)/t24-,25+/m0/s1
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AstraZeneca AB

US Patent


Assay Description
A reporter cell line (ChagoK1 18:7:2 s4/GRE) was established by stable transfection of the human bronchogenic carcinoma cell line, ChaGo K1 (ATCC: HT...


US Patent US10196374 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM332696
PNG
(US10196374, Example 22)
Show SMILES CC(C)[C@H](NC(=O)C(F)(F)F)[C@H](Oc1cc2cnn(-c3ccc(=O)n(C)c3)c2cc1Cl)c1ccccc1
Show InChI InChI=1S/C26H24ClF3N4O3/c1-15(2)23(32-25(36)26(28,29)30)24(16-7-5-4-6-8-16)37-21-11-17-13-31-34(20(17)12-19(21)27)18-9-10-22(35)33(3)14-18/h4-15,23-24H,1-3H3,(H,32,36)/t23-,24+/m0/s1
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AstraZeneca AB

US Patent


Assay Description
A reporter cell line (ChagoK1 18:7:2 s4/GRE) was established by stable transfection of the human bronchogenic carcinoma cell line, ChaGo K1 (ATCC: HT...


US Patent US10196374 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM332689
PNG
(US10196374, Example 17)
Show SMILES CC(C)[C@H](NC(=O)C(F)(F)F)[C@H](Oc1ccc2n(ncc2c1)-c1ccc(=O)n(C)c1)c1ccc(Cl)c(F)c1
Show InChI InChI=1S/C26H23ClF4N4O3/c1-14(2)23(33-25(37)26(29,30)31)24(15-4-7-19(27)20(28)11-15)38-18-6-8-21-16(10-18)12-32-35(21)17-5-9-22(36)34(3)13-17/h4-14,23-24H,1-3H3,(H,33,37)/t23-,24+/m0/s1
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AstraZeneca AB

US Patent


Assay Description
A reporter cell line (ChagoK1 18:7:2 s4/GRE) was established by stable transfection of the human bronchogenic carcinoma cell line, ChaGo K1 (ATCC: HT...


US Patent US10196374 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM332676
PNG
(US10196374, Example 4)
Show SMILES CC(C)[C@H](NC(=O)C(F)(F)F)[C@H](Oc1ccc2n(ncc2c1)-c1ccc(=O)n(C)c1)c1cc(F)cc(F)c1
Show InChI InChI=1S/C26H23F5N4O3/c1-14(2)23(33-25(37)26(29,30)31)24(15-8-17(27)11-18(28)9-15)38-20-5-6-21-16(10-20)12-32-35(21)19-4-7-22(36)34(3)13-19/h4-14,23-24H,1-3H3,(H,33,37)/t23-,24+/m0/s1
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AstraZeneca AB

US Patent


Assay Description
A reporter cell line (ChagoK1 18:7:2 s4/GRE) was established by stable transfection of the human bronchogenic carcinoma cell line, ChaGo K1 (ATCC: HT...


US Patent US10196374 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM332693
PNG
(US10196374, Example 21)
Show SMILES CC(C)[C@H](NC(=O)C(C)(F)F)[C@H](Oc1cc2cnn(-c3ccc(=O)n(C)c3)c2cc1Cl)c1ccccc1
Show InChI InChI=1S/C27H27ClF2N4O3/c1-16(2)24(32-26(36)27(3,29)30)25(17-8-6-5-7-9-17)37-22-12-18-14-31-34(21(18)13-20(22)28)19-10-11-23(35)33(4)15-19/h5-16,24-25H,1-4H3,(H,32,36)/t24-,25+/m0/s1
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AstraZeneca AB

US Patent


Assay Description
A reporter cell line (ChagoK1 18:7:2 s4/GRE) was established by stable transfection of the human bronchogenic carcinoma cell line, ChaGo K1 (ATCC: HT...


US Patent US10196374 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM332680
PNG
(US10196374, Example 8)
Show SMILES CC(C)[C@H](NC(=O)C(C)(F)F)[C@H](Oc1ccc2n(ncc2c1)-c1ccc(=O)n(C)c1)c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C27H26Cl2F2N4O3/c1-15(2)24(33-26(37)27(3,30)31)25(16-9-18(28)12-19(29)10-16)38-21-6-7-22-17(11-21)13-32-35(22)20-5-8-23(36)34(4)14-20/h5-15,24-25H,1-4H3,(H,33,37)/t24-,25+/m0/s1
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AstraZeneca AB

US Patent


Assay Description
A reporter cell line (ChagoK1 18:7:2 s4/GRE) was established by stable transfection of the human bronchogenic carcinoma cell line, ChaGo K1 (ATCC: HT...


US Patent US10196374 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM332697
PNG
(US10196374, Example 23)
Show SMILES CCn1cc(ccc1=O)-n1ncc2cc(O[C@@H]([C@@H](NC(=O)C(C)(F)F)C(C)C)c3ccccc3)ccc12
Show InChI InChI=1S/C28H30F2N4O3/c1-5-33-17-21(11-14-24(33)35)34-23-13-12-22(15-20(23)16-31-34)37-26(19-9-7-6-8-10-19)25(18(2)3)32-27(36)28(4,29)30/h6-18,25-26H,5H2,1-4H3,(H,32,36)/t25-,26+/m0/s1
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AstraZeneca AB

US Patent


Assay Description
A reporter cell line (ChagoK1 18:7:2 s4/GRE) was established by stable transfection of the human bronchogenic carcinoma cell line, ChaGo K1 (ATCC: HT...


US Patent US10196374 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM332682
PNG
(US10196374, Example 10)
Show SMILES CC(C)[C@H](NC(=O)C(C)(F)F)[C@H](Oc1ccc2n(ncc2c1)C1=C[N](C)=[C](=O)C=C1)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C28H27F5N4O3/c1-16(2)24(35-26(39)27(3,29)30)25(17-5-7-19(8-6-17)28(31,32)33)40-21-10-11-22-18(13-21)14-34-37(22)20-9-12-23(38)36(4)15-20/h5-16,24-25H,1-4H3,(H,35,39)/t24-,25+/m0/s1
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n/an/an/an/a 7.94n/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A reporter cell line (ChagoK1 18:7:2 s4/GRE) was established by stable transfection of the human bronchogenic carcinoma cell line, ChaGo K1 (ATCC: HT...


US Patent US10196374 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM332678
PNG
(US10196374, Example 6)
Show SMILES CC(C)[C@H](NC(=O)C(F)(F)F)[C@H](Oc1ccc2n(ncc2c1)-c1ccc(=O)n(C)c1)c1cccc(Cl)c1
Show InChI InChI=1S/C26H24ClF3N4O3/c1-15(2)23(32-25(36)26(28,29)30)24(16-5-4-6-18(27)11-16)37-20-8-9-21-17(12-20)13-31-34(21)19-7-10-22(35)33(3)14-19/h4-15,23-24H,1-3H3,(H,32,36)/t23-,24+/m0/s1
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n/an/an/an/a 2.51n/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A reporter cell line (ChagoK1 18:7:2 s4/GRE) was established by stable transfection of the human bronchogenic carcinoma cell line, ChaGo K1 (ATCC: HT...


US Patent US10196374 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM332685
PNG
(US10196374, Example 13)
Show SMILES CC(C)[C@H](NC(=O)C(F)(F)F)[C@H](Oc1ccc2n(ncc2c1)-c1ccc(=O)n(C)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C26H24ClF3N4O3/c1-15(2)23(32-25(36)26(28,29)30)24(16-4-6-18(27)7-5-16)37-20-9-10-21-17(12-20)13-31-34(21)19-8-11-22(35)33(3)14-19/h4-15,23-24H,1-3H3,(H,32,36)/t23-,24+/m0/s1
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n/an/an/an/a 5.01n/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A reporter cell line (ChagoK1 18:7:2 s4/GRE) was established by stable transfection of the human bronchogenic carcinoma cell line, ChaGo K1 (ATCC: HT...


US Patent US10196374 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM332683
PNG
(US10196374, Example 11)
Show SMILES CC(C)[C@H](NC(=O)C(C)(F)F)[C@H](Oc1ccc2n(ncc2c1)C1=C[N](C)=[C](=O)C=C1)c1ccc(OC(F)F)cc1
Show InChI InChI=1S/C28H28F4N4O4/c1-16(2)24(34-26(38)28(3,31)32)25(17-5-8-20(9-6-17)40-27(29)30)39-21-10-11-22-18(13-21)14-33-36(22)19-7-12-23(37)35(4)15-19/h5-16,24-25,27H,1-4H3,(H,34,38)/t24-,25+/m0/s1
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n/an/an/an/a 7.94n/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A reporter cell line (ChagoK1 18:7:2 s4/GRE) was established by stable transfection of the human bronchogenic carcinoma cell line, ChaGo K1 (ATCC: HT...


US Patent US10196374 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM332679
PNG
(US10196374, Example 7)
Show SMILES CC(C)[C@H](NC(=O)C(C)(F)F)[C@H](Oc1ccc2n(ncc2c1)-c1ccc(=O)n(C)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C27H27ClF2N4O3/c1-16(2)24(32-26(36)27(3,29)30)25(17-5-7-19(28)8-6-17)37-21-10-11-22-18(13-21)14-31-34(22)20-9-12-23(35)33(4)15-20/h5-16,24-25H,1-4H3,(H,32,36)/t24-,25+/m0/s1
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n/an/an/an/a 7.94n/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A reporter cell line (ChagoK1 18:7:2 s4/GRE) was established by stable transfection of the human bronchogenic carcinoma cell line, ChaGo K1 (ATCC: HT...


US Patent US10196374 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM332669
PNG
(US10196374, Example 3)
Show SMILES CC(C)[C@H](NC(=O)C(C)(F)F)[C@H](Oc1ccc2n(ncc2c1)-c1ccc(=O)n(C)c1)c1cc(F)cc(F)c1
Show InChI InChI=1S/C27H26F4N4O3/c1-15(2)24(33-26(37)27(3,30)31)25(16-9-18(28)12-19(29)10-16)38-21-6-7-22-17(11-21)13-32-35(22)20-5-8-23(36)34(4)14-20/h5-15,24-25H,1-4H3,(H,33,37)/t24-,25+/m0/s1
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n/an/an/an/a 2.51n/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A reporter cell line (ChagoK1 18:7:2 s4/GRE) was established by stable transfection of the human bronchogenic carcinoma cell line, ChaGo K1 (ATCC: HT...


US Patent US10196374 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM332691
PNG
(US10196374, Example 19)
Show SMILES CC(C)[C@H](NC(=O)C(C)(F)F)[C@H](Oc1ccc2n(ncc2c1)-c1ccc(=O)n(C)c1)c1cc(F)cc(Cl)c1
Show InChI InChI=1S/C27H26ClF3N4O3/c1-15(2)24(33-26(37)27(3,30)31)25(16-9-18(28)12-19(29)10-16)38-21-6-7-22-17(11-21)13-32-35(22)20-5-8-23(36)34(4)14-20/h5-15,24-25H,1-4H3,(H,33,37)/t24-,25+/m0/s1
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AstraZeneca AB

US Patent


Assay Description
A reporter cell line (ChagoK1 18:7:2 s4/GRE) was established by stable transfection of the human bronchogenic carcinoma cell line, ChaGo K1 (ATCC: HT...


US Patent US10196374 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM332681
PNG
(US10196374, Example 9)
Show SMILES CC(C)[C@H](NC(=O)C(C)(F)F)[C@H](Oc1ccc2n(ncc2c1)-c1ccc(=O)n(C)c1)c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C28H27F5N4O4/c1-16(2)24(35-26(39)27(3,29)30)25(17-5-8-20(9-6-17)41-28(31,32)33)40-21-10-11-22-18(13-21)14-34-37(22)19-7-12-23(38)36(4)15-19/h5-16,24-25H,1-4H3,(H,35,39)/t24-,25+/m0/s1
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AstraZeneca AB

US Patent


Assay Description
A reporter cell line (ChagoK1 18:7:2 s4/GRE) was established by stable transfection of the human bronchogenic carcinoma cell line, ChaGo K1 (ATCC: HT...


US Patent US10196374 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM332677
PNG
(US10196374, Example 5)
Show SMILES CC(C)[C@H](NC(=O)C(C)(F)F)[C@H](Oc1ccc2n(ncc2c1)-c1ccc(=O)n(C)c1)c1cccc(Cl)c1
Show InChI InChI=1S/C27H27ClF2N4O3/c1-16(2)24(32-26(36)27(3,29)30)25(17-6-5-7-19(28)12-17)37-21-9-10-22-18(13-21)14-31-34(22)20-8-11-23(35)33(4)15-20/h5-16,24-25H,1-4H3,(H,32,36)/t24-,25+/m0/s1
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AstraZeneca AB

US Patent


Assay Description
A reporter cell line (ChagoK1 18:7:2 s4/GRE) was established by stable transfection of the human bronchogenic carcinoma cell line, ChaGo K1 (ATCC: HT...


US Patent US10196374 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM332661
PNG
(Preparation of 2,2,2-trifluoro-N-[(1R,2S)-3-methyl...)
Show SMILES CC(C)[C@H](NC(=O)C(F)(F)F)[C@H](Oc1ccc2n(ncc2c1)-c1ccc(=O)n(C)c1)c1ccccc1
Show InChI InChI=1S/C26H25F3N4O3/c1-16(2)23(31-25(35)26(27,28)29)24(17-7-5-4-6-8-17)36-20-10-11-21-18(13-20)14-30-33(21)19-9-12-22(34)32(3)15-19/h4-16,23-24H,1-3H3,(H,31,35)/t23-,24+/m0/s1
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AstraZeneca AB

US Patent


Assay Description
A reporter cell line (ChagoK1 18:7:2 s4/GRE) was established by stable transfection of the human bronchogenic carcinoma cell line, ChaGo K1 (ATCC: HT...


US Patent US10196374 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM332692
PNG
(US10196374, Example 20)
Show SMILES CC(C)[C@H](NC(=O)C(C)(F)F)[C@H](Oc1ccc2n(ncc2c1)-c1ccc(=O)n(C)c1)c1ccc(Cl)c(F)c1
Show InChI InChI=1S/C27H26ClF3N4O3/c1-15(2)24(33-26(37)27(3,30)31)25(16-5-8-20(28)21(29)12-16)38-19-7-9-22-17(11-19)13-32-35(22)18-6-10-23(36)34(4)14-18/h5-15,24-25H,1-4H3,(H,33,37)/t24-,25+/m0/s1
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AstraZeneca AB

US Patent


Assay Description
A reporter cell line (ChagoK1 18:7:2 s4/GRE) was established by stable transfection of the human bronchogenic carcinoma cell line, ChaGo K1 (ATCC: HT...


US Patent US10196374 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM332686
PNG
(US10196374, Example 14)
Show SMILES CC(C)[C@H](NC(=O)C(F)(F)F)[C@H](Oc1ccc2n(ncc2c1)-c1ccc(=O)n(C)c1)c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C26H23Cl2F3N4O3/c1-14(2)23(33-25(37)26(29,30)31)24(15-8-17(27)11-18(28)9-15)38-20-5-6-21-16(10-20)12-32-35(21)19-4-7-22(36)34(3)13-19/h4-14,23-24H,1-3H3,(H,33,37)/t23-,24+/m0/s1
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AstraZeneca AB

US Patent


Assay Description
A reporter cell line (ChagoK1 18:7:2 s4/GRE) was established by stable transfection of the human bronchogenic carcinoma cell line, ChaGo K1 (ATCC: HT...


US Patent US10196374 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%