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Patent code US10196382

Compile Data Set for Download or QSAR
Found 6 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM332752
PNG
((2S)-2-[3-(Difluoromethoxy)phenyl]-2-methoxy-N-[6-...)
Show SMILES CO[C@H](C(=O)Nc1ccc(nn1)N1CC[C@H](C1)Nc1cccnn1)c1cccc(OC(F)F)c1
Show InChI InChI=1S/C22H23F2N7O3/c1-33-20(14-4-2-5-16(12-14)34-22(23)24)21(32)27-18-7-8-19(30-29-18)31-11-9-15(13-31)26-17-6-3-10-25-28-17/h2-8,10,12,15,20,22H,9,11,13H2,1H3,(H,26,28)(H,27,29,32)/t15-,20+/m1/s1
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PC cid
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UniChem
US Patent
n/an/a 24.7n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
GLS Enzyme Potency AssayA Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity ...


US Patent US10196382 (2019)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM332757
PNG
(N-[6-[(3R)-3-(Pyridazin-3-ylamino)pyrrolidin-1-yl]...)
Show SMILES FC(F)(F)Oc1ccccc1CC(=O)Nc1ccc(nn1)N1CC[C@H](C1)Nc1cccnn1
Show InChI InChI=1S/C21H20F3N7O2/c22-21(23,24)33-16-5-2-1-4-14(16)12-20(32)27-18-7-8-19(30-29-18)31-11-9-15(13-31)26-17-6-3-10-25-28-17/h1-8,10,15H,9,11-13H2,(H,26,28)(H,27,29,32)/t15-/m1/s1
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US Patent
n/an/a 25.2n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
GLS Enzyme Potency AssayA Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity ...


US Patent US10196382 (2019)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM332754
PNG
((2S)-2-Methoxy-2-(3-methoxyphenyl)-N-[6-[(3R)-3-(p...)
Show SMILES CO[C@H](C(=O)Nc1ccc(nn1)N1CC[C@H](C1)Nc1cccnn1)c1cccc(OC)c1
Show InChI InChI=1S/C22H25N7O3/c1-31-17-6-3-5-15(13-17)21(32-2)22(30)25-19-8-9-20(28-27-19)29-12-10-16(14-29)24-18-7-4-11-23-26-18/h3-9,11,13,16,21H,10,12,14H2,1-2H3,(H,24,26)(H,25,27,30)/t16-,21+/m1/s1
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US Patent
n/an/a 29.8n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
GLS Enzyme Potency AssayA Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity ...


US Patent US10196382 (2019)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM332756
PNG
(N-[6-[(3R)-3-(Pyridazin-3-ylamino)pyrrolidin-1-yl]...)
Show SMILES FC(F)(F)c1ccccc1CC(=O)Nc1ccc(nn1)N1CC[C@H](C1)Nc1cccnn1
Show InChI InChI=1S/C21H20F3N7O/c22-21(23,24)16-5-2-1-4-14(16)12-20(32)27-18-7-8-19(30-29-18)31-11-9-15(13-31)26-17-6-3-10-25-28-17/h1-8,10,15H,9,11-13H2,(H,26,28)(H,27,29,32)/t15-/m1/s1
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n/an/a 30.6n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
GLS Enzyme Potency AssayA Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity ...


US Patent US10196382 (2019)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM332755
PNG
(2-(2-Methoxyphenyl)-N-[6-[(3R)-3-(pyridazin-3-ylam...)
Show SMILES COc1ccccc1CC(=O)Nc1ccc(nn1)N1CC[C@H](C1)Nc1cccnn1
Show InChI InChI=1S/C21H23N7O2/c1-30-17-6-3-2-5-15(17)13-21(29)24-19-8-9-20(27-26-19)28-12-10-16(14-28)23-18-7-4-11-22-25-18/h2-9,11,16H,10,12-14H2,1H3,(H,23,25)(H,24,26,29)/t16-/m1/s1
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US Patent
n/an/a 30.9n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
GLS Enzyme Potency AssayA Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity ...


US Patent US10196382 (2019)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens)
BDBM332753
PNG
((2S)-2-[3-(Trifluoromethoxy)phenyl]-2-methoxy-N-[6...)
Show SMILES CO[C@H](C(=O)Nc1ccc(nn1)N1CC[C@H](C1)Nc1cccnn1)c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C22H22F3N7O3/c1-34-20(14-4-2-5-16(12-14)35-22(23,24)25)21(33)28-18-7-8-19(31-30-18)32-11-9-15(13-32)27-17-6-3-10-26-29-17/h2-8,10,12,15,20H,9,11,13H2,1H3,(H,27,29)(H,28,30,33)/t15-,20+/m1/s1
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PC cid
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US Patent
n/an/a 95.7n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
GLS Enzyme Potency AssayA Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity ...


US Patent US10196382 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%