Compile Data Set for Download or QSAR
maximum 50k data
Found 6 Enz. Inhib. hit(s) with all data for entry = 1611
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM332752((2S)-2-[3-(Difluoromethoxy)phenyl]-2-methoxy-N-[6-...)
Affinity DataIC50:  24.7nMAssay Description:GLS Enzyme Potency AssayA Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM332757(N-[6-[(3R)-3-(Pyridazin-3-ylamino)pyrrolidin-1-yl]...)
Affinity DataIC50:  25.2nMAssay Description:GLS Enzyme Potency AssayA Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM332754((2S)-2-Methoxy-2-(3-methoxyphenyl)-N-[6-[(3R)-3-(p...)
Affinity DataIC50:  29.8nMAssay Description:GLS Enzyme Potency AssayA Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM332756(N-[6-[(3R)-3-(Pyridazin-3-ylamino)pyrrolidin-1-yl]...)
Affinity DataIC50:  30.6nMAssay Description:GLS Enzyme Potency AssayA Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM332755(2-(2-Methoxyphenyl)-N-[6-[(3R)-3-(pyridazin-3-ylam...)
Affinity DataIC50:  30.9nMAssay Description:GLS Enzyme Potency AssayA Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM332753((2S)-2-[3-(Trifluoromethoxy)phenyl]-2-methoxy-N-[6...)
Affinity DataIC50:  95.7nMAssay Description:GLS Enzyme Potency AssayA Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent