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Patent code US10196383

Compile Data Set for Download or QSAR
Found 8 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Orexin receptor


(Homo sapiens (Human))
BDBM332759
PNG
(US10196383, Example 2)
Show SMILES CC1CCN(CCN1C(=O)c1cc(C)ccc1-n1nccn1)c1nc2ccc(F)cc2c(=O)[nH]1
Show InChI InChI=1S/C24H24FN7O2/c1-15-3-6-21(32-26-8-9-27-32)19(13-15)23(34)31-12-11-30(10-7-16(31)2)24-28-20-5-4-17(25)14-18(20)22(33)29-24/h3-6,8-9,13-14,16H,7,10-12H2,1-2H3,(H,28,29,33)
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US Patent
n/an/a 169n/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The capability of the compounds to antagonism of humanized OX2 receptor transfected by the HEK-293 cells was evaluated by the method of fluorescence ...


US Patent US10196383 (2019)

More data for this
Ligand-Target Pair
Orexin receptor


(Homo sapiens (Human))
BDBM332761
PNG
(US10196383, Example 6)
Show SMILES CC1CCN(CCN1C(=O)c1cc(C)ccc1-n1nccn1)c1nc2ccc(Cl)cc2c(=O)[nH]1
Show InChI InChI=1S/C24H24ClN7O2/c1-15-3-6-21(32-26-8-9-27-32)19(13-15)23(34)31-12-11-30(10-7-16(31)2)24-28-20-5-4-17(25)14-18(20)22(33)29-24/h3-6,8-9,13-14,16H,7,10-12H2,1-2H3,(H,28,29,33)
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n/an/a 221n/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The capability of the compounds to antagonism of humanized OX2 receptor transfected by the HEK-293 cells was evaluated by the method of fluorescence ...


US Patent US10196383 (2019)

More data for this
Ligand-Target Pair
Orexin receptor


(Homo sapiens (Human))
BDBM332760
PNG
(US10196383, Example 5)
Show SMILES Cc1ccc(c(c1)C(=O)N1CCCN(CC1)c1nc2ccc(Cl)cc2c(=O)[nH]1)-n1nccn1
Show InChI InChI=1S/C23H22ClN7O2/c1-15-3-6-20(31-25-7-8-26-31)18(13-15)22(33)29-9-2-10-30(12-11-29)23-27-19-5-4-16(24)14-17(19)21(32)28-23/h3-8,13-14H,2,9-12H2,1H3,(H,27,28,32)
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n/an/a 263n/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The capability of the compounds to antagonism of humanized OX2 receptor transfected by the HEK-293 cells was evaluated by the method of fluorescence ...


US Patent US10196383 (2019)

More data for this
Ligand-Target Pair
Orexin receptor


(Homo sapiens (Human))
BDBM332760
PNG
(US10196383, Example 5)
Show SMILES Cc1ccc(c(c1)C(=O)N1CCCN(CC1)c1nc2ccc(Cl)cc2c(=O)[nH]1)-n1nccn1
Show InChI InChI=1S/C23H22ClN7O2/c1-15-3-6-20(31-25-7-8-26-31)18(13-15)22(33)29-9-2-10-30(12-11-29)23-27-19-5-4-16(24)14-17(19)21(32)28-23/h3-8,13-14H,2,9-12H2,1H3,(H,27,28,32)
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n/an/a 276n/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The capability of the compounds to the antagonism of humanized OX1 receptor transfected to the Chinese hamster ovary (CHO) cells was evaluated by the...


US Patent US10196383 (2019)

More data for this
Ligand-Target Pair
Orexin receptor


(Homo sapiens (Human))
BDBM332758
PNG
(US10196383, Example 1)
Show SMILES Cc1ccc(c(c1)C(=O)N1CCCN(CC1)c1nc2ccc(F)cc2c(=O)[nH]1)-n1nccn1
Show InChI InChI=1S/C23H22FN7O2/c1-15-3-6-20(31-25-7-8-26-31)18(13-15)22(33)29-9-2-10-30(12-11-29)23-27-19-5-4-16(24)14-17(19)21(32)28-23/h3-8,13-14H,2,9-12H2,1H3,(H,27,28,32)
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US Patent
n/an/a 300n/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The capability of the compounds to antagonism of humanized OX2 receptor transfected by the HEK-293 cells was evaluated by the method of fluorescence ...


US Patent US10196383 (2019)

More data for this
Ligand-Target Pair
Orexin receptor


(Homo sapiens (Human))
BDBM332758
PNG
(US10196383, Example 1)
Show SMILES Cc1ccc(c(c1)C(=O)N1CCCN(CC1)c1nc2ccc(F)cc2c(=O)[nH]1)-n1nccn1
Show InChI InChI=1S/C23H22FN7O2/c1-15-3-6-20(31-25-7-8-26-31)18(13-15)22(33)29-9-2-10-30(12-11-29)23-27-19-5-4-16(24)14-17(19)21(32)28-23/h3-8,13-14H,2,9-12H2,1H3,(H,27,28,32)
PDB

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n/an/a 322n/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The capability of the compounds to the antagonism of humanized OX1 receptor transfected to the Chinese hamster ovary (CHO) cells was evaluated by the...


US Patent US10196383 (2019)

More data for this
Ligand-Target Pair
Orexin receptor


(Homo sapiens (Human))
BDBM332761
PNG
(US10196383, Example 6)
Show SMILES CC1CCN(CCN1C(=O)c1cc(C)ccc1-n1nccn1)c1nc2ccc(Cl)cc2c(=O)[nH]1
Show InChI InChI=1S/C24H24ClN7O2/c1-15-3-6-21(32-26-8-9-27-32)19(13-15)23(34)31-12-11-30(10-7-16(31)2)24-28-20-5-4-17(25)14-18(20)22(33)29-24/h3-6,8-9,13-14,16H,7,10-12H2,1-2H3,(H,28,29,33)
PDB

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US Patent
n/an/a 367n/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The capability of the compounds to the antagonism of humanized OX1 receptor transfected to the Chinese hamster ovary (CHO) cells was evaluated by the...


US Patent US10196383 (2019)

More data for this
Ligand-Target Pair
Orexin receptor


(Homo sapiens (Human))
BDBM332759
PNG
(US10196383, Example 2)
Show SMILES CC1CCN(CCN1C(=O)c1cc(C)ccc1-n1nccn1)c1nc2ccc(F)cc2c(=O)[nH]1
Show InChI InChI=1S/C24H24FN7O2/c1-15-3-6-21(32-26-8-9-27-32)19(13-15)23(34)31-12-11-30(10-7-16(31)2)24-28-20-5-4-17(25)14-18(20)22(33)29-24/h3-6,8-9,13-14,16H,7,10-12H2,1-2H3,(H,28,29,33)
PDB

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US Patent
n/an/a 543n/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The capability of the compounds to the antagonism of humanized OX1 receptor transfected to the Chinese hamster ovary (CHO) cells was evaluated by the...


US Patent US10196383 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%