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Patent code US10196385

Compile Data Set for Download or QSAR
Found 3 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Probable G-protein coupled receptor 142


(Homo sapiens)		BDBM332762
PNG
(Cis-(chiral)-N-[(2-[5-(1,4-Dimethyl-1H-imidazol-5-...)
Show SMILES CN([C@@H]1CCO[C@@H](C1)c1nnc([nH]1)-c1c(C)ncn1C)C(=O)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C21H23F3N6O2/c1-12-17(29(2)11-25-12)19-26-18(27-28-19)16-10-15(7-8-32-16)30(3)20(31)13-5-4-6-14(9-13)21(22,23)24/h4-6,9,11,15-16H,7-8,10H2,1-3H3,(H,26,27,28)/t15-,16+/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 43.5n/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
HEK293 cells expressing human GPR142 are maintained in DMEM supplemented with 10% FBS and 800 μg/ml G418 (Geneticin) at 37° C. and 5% CO2. The c...

US Patent US10196385 (2019)

More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens)		BDBM332764
PNG
(Cis-(chiral)-3-Chloro-N-[2- [5-(1,4-dimethyl-1H- i...)
Show SMILES CN([C@@H]1CCO[C@@H](C1)c1nnc([nH]1)-c1c(C)ncn1C)C(=O)c1cccc(Cl)c1
Show InChI InChI=1S/C20H23ClN6O2/c1-12-17(26(2)11-22-12)19-23-18(24-25-19)16-10-15(7-8-29-16)27(3)20(28)13-5-4-6-14(21)9-13/h4-6,9,11,15-16H,7-8,10H2,1-3H3,(H,23,24,25)/t15-,16+/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 27.2n/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
HEK293 cells expressing human GPR142 are maintained in DMEM supplemented with 10% FBS and 800 μg/ml G418 (Geneticin) at 37° C. and 5% CO2. The c...

US Patent US10196385 (2019)

More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens)		BDBM332763
PNG
(Cis-(chiral)-N-[2-[5-(1,4- Dimethyl-1H-imidazol-5-...)
Show SMILES CN([C@@H]1CCO[C@@H](C1)c1nnc([nH]1)-c1c(C)ncn1C)C(=O)c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C21H23F3N6O3/c1-12-17(29(2)11-25-12)19-26-18(27-28-19)16-10-14(7-8-32-16)30(3)20(31)13-5-4-6-15(9-13)33-21(22,23)24/h4-6,9,11,14,16H,7-8,10H2,1-3H3,(H,26,27,28)/t14-,16+/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 30.1n/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
HEK293 cells expressing human GPR142 are maintained in DMEM supplemented with 10% FBS and 800 μg/ml G418 (Geneticin) at 37° C. and 5% CO2. The c...

US Patent US10196385 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%