BindingDB logo
myBDB logout

Patent code US10196390

Compile Data Set for Download or QSAR

Found 466 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM332935
PNG
(US10196390, Compound I-224)
Show SMILES CN1CCN[C@@](C)(C1=O)c1ccc(Nc2cc(nc3CNC(=O)c23)-c2c(F)cccc2F)nc1
Show InChI InChI=1S/C24H22F2N6O2/c1-24(23(34)32(2)9-8-29-24)13-6-7-19(27-11-13)31-17-10-16(20-14(25)4-3-5-15(20)26)30-18-12-28-22(33)21(17)18/h3-7,10-11,29H,8-9,12H2,1-2H3,(H,28,33)(H,27,30,31)/t24-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent




US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332967
PNG
(US10196390, Compound I-256)
Show SMILES CC(C)N1CCN(CC1)c1ccc(Nc2cc(nc3CNC(=O)c23)-c2c(F)cccc2F)nc1
Show InChI InChI=1S/C25H26F2N6O/c1-15(2)32-8-10-33(11-9-32)16-6-7-22(28-13-16)31-20-12-19(23-17(26)4-3-5-18(23)27)30-21-14-29-25(34)24(20)21/h3-7,12-13,15H,8-11,14H2,1-2H3,(H,29,34)(H,28,30,31)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332973
PNG
(US10196390, Compound I-262)
Show SMILES Fc1cccc(F)c1-c1cc(Nc2ccc(cn2)N2CCN(CCC(F)(F)F)CC2)c2C(=O)NCc2n1
Show InChI InChI=1S/C25H23F5N6O/c26-16-2-1-3-17(27)22(16)18-12-19(23-20(33-18)14-32-24(23)37)34-21-5-4-15(13-31-21)36-10-8-35(9-11-36)7-6-25(28,29)30/h1-5,12-13H,6-11,14H2,(H,32,37)(H,31,33,34)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM332977
PNG
(US10196390, Compound I-266)
Show SMILES CC1(C)CN(CCC1O)c1ccc(Nc2cc(nc3CNC(=O)c23)-c2c(F)cccc2F)nc1
Show InChI InChI=1S/C25H25F2N5O2/c1-25(2)13-32(9-8-20(25)33)14-6-7-21(28-11-14)31-18-10-17(22-15(26)4-3-5-16(22)27)30-19-12-29-24(34)23(18)19/h3-7,10-11,20,33H,8-9,12-13H2,1-2H3,(H,29,34)(H,28,30,31)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent




US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332980
PNG
(US10196390, Compound I-269)
Show SMILES OC1CCCN(C1)c1ccc(Nc2cc(nc3CNC(=O)c23)-c2c(F)cccc2F)nc1
Show InChI InChI=1S/C23H21F2N5O2/c24-15-4-1-5-16(25)21(15)17-9-18(22-19(28-17)11-27-23(22)32)29-20-7-6-13(10-26-20)30-8-2-3-14(31)12-30/h1,4-7,9-10,14,31H,2-3,8,11-12H2,(H,27,32)(H,26,28,29)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM332981
PNG
(US10196390, Compound I-270)
Show SMILES O[C@H]1CCCN(C1)c1ccc(Nc2cc(nc3CNC(=O)c23)-c2c(F)cccc2F)nc1
Show InChI InChI=1S/C23H21F2N5O2/c24-15-4-1-5-16(25)21(15)17-9-18(22-19(28-17)11-27-23(22)32)29-20-7-6-13(10-26-20)30-8-2-3-14(31)12-30/h1,4-7,9-10,14,31H,2-3,8,11-12H2,(H,27,32)(H,26,28,29)/t14-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent




US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332987
PNG
(US10196390, Compound I-276)
Show SMILES Fc1cccc(F)c1-c1cc(Nc2ccc(NC3CCC3)cn2)c2C(=O)NCc2n1
Show InChI InChI=1S/C22H19F2N5O/c23-14-5-2-6-15(24)20(14)16-9-17(21-18(28-16)11-26-22(21)30)29-19-8-7-13(10-25-19)27-12-3-1-4-12/h2,5-10,12,27H,1,3-4,11H2,(H,26,30)(H,25,28,29)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332995
PNG
(US10196390, Compound I-284)
Show SMILES CC1(C)CCCC(=O)N1c1ccc(Nc2cc(nc3CNC(=O)c23)-c2c(F)cccc2F)nc1
Show InChI InChI=1S/C25H23F2N5O2/c1-25(2)10-4-7-21(33)32(25)14-8-9-20(28-12-14)31-18-11-17(22-15(26)5-3-6-16(22)27)30-19-13-29-24(34)23(18)19/h3,5-6,8-9,11-12H,4,7,10,13H2,1-2H3,(H,29,34)(H,28,30,31)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332769
PNG
(US10196390, Compound I-5)
Show SMILES CCOC(=O)Cc1ccc(Nc2nc(nc3CNC(=O)c23)-c2c(Cl)cccc2Cl)cc1
Show InChI InChI=1S/C22H18Cl2N4O3/c1-2-31-17(29)10-12-6-8-13(9-7-12)26-21-19-16(11-25-22(19)30)27-20(28-21)18-14(23)4-3-5-15(18)24/h3-9H,2,10-11H2,1H3,(H,25,30)(H,26,27,28)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332780
PNG
(US10196390, Compound I-16)
Show SMILES OC[C@@H]1CCCN1C(=O)Cc1ccc(Nc2nc(nc3CNC(=O)c23)-c2c(F)cccc2F)cc1
Show InChI InChI=1S/C25H23F2N5O3/c26-17-4-1-5-18(27)21(17)23-30-19-12-28-25(35)22(19)24(31-23)29-15-8-6-14(7-9-15)11-20(34)32-10-2-3-16(32)13-33/h1,4-9,16,33H,2-3,10-13H2,(H,28,35)(H,29,30,31)/t16-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332805
PNG
(US10196390, Compound I-78)
Show SMILES FC(F)CN1CCN(CC1)C(=O)Cc1ccc(Nc2nc(nc3CNC(=O)c23)-c2c(F)cccc2F)cc1
Show InChI InChI=1S/C26H24F4N6O2/c27-17-2-1-3-18(28)22(17)24-33-19-13-31-26(38)23(19)25(34-24)32-16-6-4-15(5-7-16)12-21(37)36-10-8-35(9-11-36)14-20(29)30/h1-7,20H,8-14H2,(H,31,38)(H,32,33,34)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332806
PNG
(US10196390, Compound I-79)
Show SMILES OCCNC(=O)Cc1ccc(Nc2nc(nc3CNC(=O)c23)-c2c(F)cccc2F)cc1
Show InChI InChI=1S/C22H19F2N5O3/c23-14-2-1-3-15(24)18(14)20-28-16-11-26-22(32)19(16)21(29-20)27-13-6-4-12(5-7-13)10-17(31)25-8-9-30/h1-7,30H,8-11H2,(H,25,31)(H,26,32)(H,27,28,29)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332815
PNG
(US10196390, Compound I-87)
Show SMILES Fc1cccc(F)c1-c1nc2CNC(=O)c2c(Nc2ccc(cc2)[C@@H]2CCNC2=O)n1
Show InChI InChI=1S/C22H17F2N5O2/c23-14-2-1-3-15(24)17(14)19-28-16-10-26-22(31)18(16)20(29-19)27-12-6-4-11(5-7-12)13-8-9-25-21(13)30/h1-7,13H,8-10H2,(H,25,30)(H,26,31)(H,27,28,29)/t13-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332832
PNG
(US10196390, Compound I-122)
Show SMILES Fc1cccc(F)c1-c1nc2CNC(=O)c2c(Nc2ccc(cc2)[C@H]2CCN(CCN3CCOCC3)C2=O)n1
Show InChI InChI=1S/C28H28F2N6O3/c29-20-2-1-3-21(30)23(20)25-33-22-16-31-27(37)24(22)26(34-25)32-18-6-4-17(5-7-18)19-8-9-36(28(19)38)11-10-35-12-14-39-15-13-35/h1-7,19H,8-16H2,(H,31,37)(H,32,33,34)/t19-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332838
PNG
(US10196390, Compound I-128)
Show SMILES Fc1cccc(F)c1-c1nc2CNC(=O)c2c(Nc2ccc(Cn3ccnn3)cc2)n1
Show InChI InChI=1S/C21H15F2N7O/c22-14-2-1-3-15(23)17(14)19-27-16-10-24-21(31)18(16)20(28-19)26-13-6-4-12(5-7-13)11-30-9-8-25-29-30/h1-9H,10-11H2,(H,24,31)(H,26,27,28)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332849
PNG
(US10196390, Compound I-138)
Show SMILES CC(C)NC(=O)c1ccc(Nc2cc(nc3CNC(=O)c23)-c2c(F)cccc2F)nc1
Show InChI InChI=1S/C22H19F2N5O2/c1-11(2)27-21(30)12-6-7-18(25-9-12)29-16-8-15(19-13(23)4-3-5-14(19)24)28-17-10-26-22(31)20(16)17/h3-9,11H,10H2,1-2H3,(H,26,31)(H,27,30)(H,25,28,29)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332860
PNG
(US10196390, Compound I-149)
Show SMILES OCCN1CCC(C1=O)c1ccc(Nc2nc(nc3CNC(=O)c23)-c2c(F)cccc2F)cc1
Show InChI InChI=1S/C24H21F2N5O3/c25-16-2-1-3-17(26)19(16)21-29-18-12-27-23(33)20(18)22(30-21)28-14-6-4-13(5-7-14)15-8-9-31(10-11-32)24(15)34/h1-7,15,32H,8-12H2,(H,27,33)(H,28,29,30)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332864
PNG
(US10196390, Compound I-153)
Show SMILES Fc1cccc(F)c1-c1nc2CNC(=O)c2c(Nc2ccc(cc2)C2CCCNC2=O)n1
Show InChI InChI=1S/C23H19F2N5O2/c24-15-4-1-5-16(25)18(15)20-29-17-11-27-23(32)19(17)21(30-20)28-13-8-6-12(7-9-13)14-3-2-10-26-22(14)31/h1,4-9,14H,2-3,10-11H2,(H,26,31)(H,27,32)(H,28,29,30)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332876
PNG
(US10196390, Compound I-165)
Show SMILES CC(C)(C)NC(=O)c1ccc(Nc2cc(nc3CNC(=O)c23)-c2c(F)cccc2F)nc1
Show InChI InChI=1S/C23H21F2N5O2/c1-23(2,3)30-21(31)12-7-8-18(26-10-12)29-16-9-15(19-13(24)5-4-6-14(19)25)28-17-11-27-22(32)20(16)17/h4-10H,11H2,1-3H3,(H,27,32)(H,30,31)(H,26,28,29)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332904
PNG
(US10196390, Compound I-193)
Show SMILES CN(CC(C)(C)O)C(=O)Cc1ccc(Nc2nc(nc3CNC(=O)c23)-c2c(F)cccc2F)cc1
Show InChI InChI=1S/C25H25F2N5O3/c1-25(2,35)13-32(3)19(33)11-14-7-9-15(10-8-14)29-23-21-18(12-28-24(21)34)30-22(31-23)20-16(26)5-4-6-17(20)27/h4-10,35H,11-13H2,1-3H3,(H,28,34)(H,29,30,31)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332910
PNG
(US10196390, Compound I-199)
Show SMILES CCNC(=O)Cc1ccc(Nc2cc(nc3CNC(=O)c23)-c2c(F)cccc2Cl)nc1
Show InChI InChI=1S/C22H19ClFN5O2/c1-2-25-19(30)8-12-6-7-18(26-10-12)29-16-9-15(20-13(23)4-3-5-14(20)24)28-17-11-27-22(31)21(16)17/h3-7,9-10H,2,8,11H2,1H3,(H,25,30)(H,27,31)(H,26,28,29)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332913
PNG
(US10196390, Compound I-202)
Show SMILES OC(=O)C1COCCN1C(=O)Cc1ccc(Nc2nc(nc3CNC(=O)c23)-c2c(F)cccc2F)cc1
Show InChI InChI=1S/C25H21F2N5O5/c26-15-2-1-3-16(27)20(15)22-30-17-11-28-24(34)21(17)23(31-22)29-14-6-4-13(5-7-14)10-19(33)32-8-9-37-12-18(32)25(35)36/h1-7,18H,8-12H2,(H,28,34)(H,35,36)(H,29,30,31)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332921
PNG
(US10196390, Compound I-210)
Show SMILES CN1CCN(C)[C@@](C)(C1=O)c1ccc(Nc2nc(nc3CNC(=O)c23)-c2c(F)cccc2F)cc1
Show InChI InChI=1S/C25H24F2N6O2/c1-25(24(35)32(2)11-12-33(25)3)14-7-9-15(10-8-14)29-22-20-18(13-28-23(20)34)30-21(31-22)19-16(26)5-4-6-17(19)27/h4-10H,11-13H2,1-3H3,(H,28,34)(H,29,30,31)/t25-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332923
PNG
(US10196390, Compound I-212)
Show SMILES Fc1cccc(F)c1-c1cc(Nc2ccc(cn2)C(=O)N2CCOCC2)c2C(=O)NCc2n1
Show InChI InChI=1S/C23H19F2N5O3/c24-14-2-1-3-15(25)20(14)16-10-17(21-18(28-16)12-27-22(21)31)29-19-5-4-13(11-26-19)23(32)30-6-8-33-9-7-30/h1-5,10-11H,6-9,12H2,(H,27,31)(H,26,28,29)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332936
PNG
(US10196390, Compound I-225)
Show SMILES CN1CCN[C@](C)(C1=O)c1ccc(Nc2cc(nc3CNC(=O)c23)-c2c(F)cccc2F)nc1
Show InChI InChI=1S/C24H22F2N6O2/c1-24(23(34)32(2)9-8-29-24)13-6-7-19(27-11-13)31-17-10-16(20-14(25)4-3-5-15(20)26)30-18-12-28-22(33)21(17)18/h3-7,10-11,29H,8-9,12H2,1-2H3,(H,28,33)(H,27,30,31)/t24-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM332967
PNG
(US10196390, Compound I-256)
Show SMILES CC(C)N1CCN(CC1)c1ccc(Nc2cc(nc3CNC(=O)c23)-c2c(F)cccc2F)nc1
Show InChI InChI=1S/C25H26F2N6O/c1-15(2)32-8-10-33(11-9-32)16-6-7-22(28-13-16)31-20-12-19(23-17(26)4-3-5-18(23)27)30-21-14-29-25(34)24(20)21/h3-7,12-13,15H,8-11,14H2,1-2H3,(H,29,34)(H,28,30,31)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent




US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM332969
PNG
(US10196390, Compound I-258)
Show SMILES COc1ccc(Nc2cc(nc3CNC(=O)c23)-c2c(F)cccc2C#N)nc1
Show InChI InChI=1S/C20H14FN5O2/c1-28-12-5-6-17(23-9-12)26-15-7-14(25-16-10-24-20(27)19(15)16)18-11(8-22)3-2-4-13(18)21/h2-7,9H,10H2,1H3,(H,24,27)(H,23,25,26)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent




US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332970
PNG
(US10196390, Compound I-259)
Show SMILES CCN(CC)C(=O)c1ccc(Nc2cc(nc3CNC(=O)c23)-c2c(F)cccc2F)cc1
Show InChI InChI=1S/C24H22F2N4O2/c1-3-30(4-2)24(32)14-8-10-15(11-9-14)28-19-12-18(21-16(25)6-5-7-17(21)26)29-20-13-27-23(31)22(19)20/h5-12H,3-4,13H2,1-2H3,(H,27,31)(H,28,29)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332974
PNG
(US10196390, Compound I-263)
Show SMILES C[C@@H]1COC[C@@H](C)N1c1ccc(Nc2cc(nc3CNC(=O)c23)-c2c(F)cccc2F)nc1
Show InChI InChI=1S/C24H23F2N5O2/c1-13-11-33-12-14(2)31(13)15-6-7-21(27-9-15)30-19-8-18(22-16(25)4-3-5-17(22)26)29-20-10-28-24(32)23(19)20/h3-9,13-14H,10-12H2,1-2H3,(H,28,32)(H,27,29,30)/t13-,14-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM332993
PNG
(US10196390, Compound I-282)
Show SMILES CCNC(=O)c1ccc(Nc2cc(nc3CNC(=O)c23)-c2c(F)cccc2C#N)nc1
Show InChI InChI=1S/C22H17FN6O2/c1-2-25-21(30)13-6-7-18(26-10-13)29-16-8-15(28-17-11-27-22(31)20(16)17)19-12(9-24)4-3-5-14(19)23/h3-8,10H,2,11H2,1H3,(H,25,30)(H,27,31)(H,26,28,29)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent




US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM332996
PNG
(US10196390, Compound I-285)
Show SMILES C[C@@H]1COC[C@@H](C)N1C(=O)c1ccc(Nc2cc(nc3CNC(=O)c23)-c2c(F)cccc2F)cc1
Show InChI InChI=1S/C26H24F2N4O3/c1-14-12-35-13-15(2)32(14)26(34)16-6-8-17(9-7-16)30-21-10-20(23-18(27)4-3-5-19(23)28)31-22-11-29-25(33)24(21)22/h3-10,14-15H,11-13H2,1-2H3,(H,29,33)(H,30,31)/t14-,15-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent




US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM332999
PNG
(US10196390, Compound I-288)
Show SMILES CC1CC(O)CC(C)N1c1ccc(Nc2cc(nc3CNC(=O)c23)-c2c(F)cccc2F)nc1
Show InChI InChI=1S/C25H25F2N5O2/c1-13-8-16(33)9-14(2)32(13)15-6-7-22(28-11-15)31-20-10-19(23-17(26)4-3-5-18(23)27)30-21-12-29-25(34)24(20)21/h3-7,10-11,13-14,16,33H,8-9,12H2,1-2H3,(H,29,34)(H,28,30,31)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent




US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332885
PNG
(US10196390, Compound I-174)
Show SMILES C[C@@]1(NC(=O)NC1=O)c1ccc(Nc2nc(nc3CNC(=O)c23)-c2c(F)cccc2F)cc1
Show InChI InChI=1S/C22H16F2N6O3/c1-22(20(32)29-21(33)30-22)10-5-7-11(8-6-10)26-18-16-14(9-25-19(16)31)27-17(28-18)15-12(23)3-2-4-13(15)24/h2-8H,9H2,1H3,(H,25,31)(H,26,27,28)(H2,29,30,32,33)/t22-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332889
PNG
(US10196390, Compound I-178)
Show SMILES CCOC(=O)C(C)(C)c1ccc(Nc2nc(nc3CNC(=O)c23)-c2c(F)cccc2F)cc1
Show InChI InChI=1S/C24H22F2N4O3/c1-4-33-23(32)24(2,3)13-8-10-14(11-9-13)28-21-19-17(12-27-22(19)31)29-20(30-21)18-15(25)6-5-7-16(18)26/h5-11H,4,12H2,1-3H3,(H,27,31)(H,28,29,30)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332894
PNG
(US10196390, Compound I-183)
Show SMILES COc1ccc(Nc2nc(nc3CNC(=O)c23)N2[C@@H](C)CCC[C@H]2C)cc1
Show InChI InChI=1S/C20H25N5O2/c1-12-5-4-6-13(2)25(12)20-23-16-11-21-19(26)17(16)18(24-20)22-14-7-9-15(27-3)10-8-14/h7-10,12-13H,4-6,11H2,1-3H3,(H,21,26)(H,22,23,24)/t12-,13+
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332896
PNG
(US10196390, Compound I-185)
Show SMILES COCCOc1ccc(Nc2nc(nc3CNC(=O)c23)-c2c(F)cccc2F)cc1
Show InChI InChI=1S/C21H18F2N4O3/c1-29-9-10-30-13-7-5-12(6-8-13)25-20-18-16(11-24-21(18)28)26-19(27-20)17-14(22)3-2-4-15(17)23/h2-8H,9-11H2,1H3,(H,24,28)(H,25,26,27)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332911
PNG
(US10196390, Compound I-200)
Show SMILES COC(=O)Cc1ccc(Nc2cc(nc3CNC(=O)c23)-c2c(F)cccc2Cl)nc1
Show InChI InChI=1S/C21H16ClFN4O3/c1-30-18(28)7-11-5-6-17(24-9-11)27-15-8-14(19-12(22)3-2-4-13(19)23)26-16-10-25-21(29)20(15)16/h2-6,8-9H,7,10H2,1H3,(H,25,29)(H,24,26,27)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332917
PNG
(US10196390, Compound I-206)
Show SMILES C[C@H](C(=O)N1CCCCC1)c1ccc(Nc2nc(nc3CNC(=O)c23)-c2c(F)cccc2F)cc1
Show InChI InChI=1S/C26H25F2N5O2/c1-15(26(35)33-12-3-2-4-13-33)16-8-10-17(11-9-16)30-24-22-20(14-29-25(22)34)31-23(32-24)21-18(27)6-5-7-19(21)28/h5-11,15H,2-4,12-14H2,1H3,(H,29,34)(H,30,31,32)/t15-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM332938
PNG
(US10196390, Compound I-227)
Show SMILES CC(C)(C)N1CCN(CC1)c1ccc(Nc2cc(nc3CNC(=O)c23)-c2c(F)cccc2F)nc1
Show InChI InChI=1S/C26H28F2N6O/c1-26(2,3)34-11-9-33(10-12-34)16-7-8-22(29-14-16)32-20-13-19(23-17(27)5-4-6-18(23)28)31-21-15-30-25(35)24(20)21/h4-8,13-14H,9-12,15H2,1-3H3,(H,30,35)(H,29,31,32)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent




US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332948
PNG
(US10196390, Compound I-237)
Show SMILES CC(=O)Nc1ccc(Nc2cc(nc3CNC(=O)c23)-c2c(F)cccc2F)nc1
Show InChI InChI=1S/C20H15F2N5O2/c1-10(28)25-11-5-6-17(23-8-11)27-15-7-14(18-12(21)3-2-4-13(18)22)26-16-9-24-20(29)19(15)16/h2-8H,9H2,1H3,(H,24,29)(H,25,28)(H,23,26,27)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM332957
PNG
(US10196390, Compound I-246)
Show SMILES C[C@@H]1COCCN1c1ccc(Nc2cc(nc3CNC(=O)c23)-c2c(F)cccc2F)nc1
Show InChI InChI=1S/C23H21F2N5O2/c1-13-12-32-8-7-30(13)14-5-6-20(26-10-14)29-18-9-17(21-15(24)3-2-4-16(21)25)28-19-11-27-23(31)22(18)19/h2-6,9-10,13H,7-8,11-12H2,1H3,(H,27,31)(H,26,28,29)/t13-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent




US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332958
PNG
(US10196390, Compound I-247)
Show SMILES FC(F)CN1CCN(CC1)c1ccc(Nc2cc(nc3CNC(=O)c23)-c2c(F)cccc2F)nc1
Show InChI InChI=1S/C24H22F4N6O/c25-15-2-1-3-16(26)22(15)17-10-18(23-19(31-17)12-30-24(23)35)32-21-5-4-14(11-29-21)34-8-6-33(7-9-34)13-20(27)28/h1-5,10-11,20H,6-9,12-13H2,(H,30,35)(H,29,31,32)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332960
PNG
(US10196390, Compound I-249)
Show SMILES Fc1cccc(F)c1-c1cc(Nc2ccc(cn2)C2=CCOCC2)c2C(=O)NCc2n1
Show InChI InChI=1S/C23H18F2N4O2/c24-15-2-1-3-16(25)21(15)17-10-18(22-19(28-17)12-27-23(22)30)29-20-5-4-14(11-26-20)13-6-8-31-9-7-13/h1-6,10-11H,7-9,12H2,(H,27,30)(H,26,28,29)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332962
PNG
(US10196390, Compound I-251)
Show SMILES OC1(CCOCC1)c1ccc(Nc2cc(nc3CNC(=O)c23)-c2c(F)cccc2F)nc1
Show InChI InChI=1S/C23H20F2N4O3/c24-14-2-1-3-15(25)20(14)16-10-17(21-18(28-16)12-27-22(21)30)29-19-5-4-13(11-26-19)23(31)6-8-32-9-7-23/h1-5,10-11,31H,6-9,12H2,(H,27,30)(H,26,28,29)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332975
PNG
(US10196390, Compound I-264)
Show SMILES C[C@H]1COC[C@H](C)N1c1ccc(Nc2cc(nc3CNC(=O)c23)-c2c(F)cccc2F)nc1
Show InChI InChI=1S/C24H23F2N5O2/c1-13-11-33-12-14(2)31(13)15-6-7-21(27-9-15)30-19-8-18(22-16(25)4-3-5-17(22)26)29-20-10-28-24(32)23(19)20/h3-9,13-14H,10-12H2,1-2H3,(H,28,32)(H,27,29,30)/t13-,14-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332984
PNG
(US10196390, Compound I-273)
Show SMILES CC1(C)OCCN(C1=O)c1ccc(Nc2cc(nc3CNC(=O)c23)-c2c(F)cccc2F)nc1
Show InChI InChI=1S/C24H21F2N5O3/c1-24(2)23(33)31(8-9-34-24)13-6-7-19(27-11-13)30-17-10-16(20-14(25)4-3-5-15(20)26)29-18-12-28-22(32)21(17)18/h3-7,10-11H,8-9,12H2,1-2H3,(H,28,32)(H,27,29,30)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM332985
PNG
(US10196390, Compound I-274)
Show SMILES CN(c1ccc(Nc2cc(nc3CNC(=O)c23)-c2c(F)cccc2F)nc1)C(C)(C)C
Show InChI InChI=1S/C23H23F2N5O/c1-23(2,3)30(4)13-8-9-19(26-11-13)29-17-10-16(20-14(24)6-5-7-15(20)25)28-18-12-27-22(31)21(17)18/h5-11H,12H2,1-4H3,(H,27,31)(H,26,28,29)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent




US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM332989
PNG
(US10196390, Compound I-278)
Show SMILES CC(C)(C)Nc1ccc(Nc2cc(nc3CNC(=O)c23)-c2c(F)cccc2F)nc1
Show InChI InChI=1S/C22H21F2N5O/c1-22(2,3)29-12-7-8-18(25-10-12)28-16-9-15(19-13(23)5-4-6-14(19)24)27-17-11-26-21(30)20(16)17/h4-10,29H,11H2,1-3H3,(H,26,30)(H,25,27,28)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent




US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332993
PNG
(US10196390, Compound I-282)
Show SMILES CCNC(=O)c1ccc(Nc2cc(nc3CNC(=O)c23)-c2c(F)cccc2C#N)nc1
Show InChI InChI=1S/C22H17FN6O2/c1-2-25-21(30)13-6-7-18(26-10-13)29-16-8-15(28-17-11-27-22(31)20(16)17)19-12(9-24)4-3-5-14(19)23/h3-8,10H,2,11H2,1H3,(H,25,30)(H,27,31)(H,26,28,29)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332768
PNG
(US10196390, Compound I-4)
Show SMILES CCOC(=O)Cc1ccc(Nc2nc(nc3CNC(=O)c23)-c2c(F)cccc2Cl)cc1
Show InChI InChI=1S/C22H18ClFN4O3/c1-2-31-17(29)10-12-6-8-13(9-7-12)26-21-19-16(11-25-22(19)30)27-20(28-21)18-14(23)4-3-5-15(18)24/h3-9H,2,10-11H2,1H3,(H,25,30)(H,26,27,28)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 466 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%