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Patent code US10196391

Compile Data Set for Download or QSAR
Found 120 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333026
PNG
(US10196391, Example 26)
Show SMILES COc1cc(cc(F)c1F)N1CCc2nc(ncc2C1)-c1ncccn1
Show InChI InChI=1S/C18H15F2N5O/c1-26-15-8-12(7-13(19)16(15)20)25-6-3-14-11(10-25)9-23-18(24-14)17-21-4-2-5-22-17/h2,4-5,7-9H,3,6,10H2,1H3
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333095
PNG
(US10196391, Example 95)
Show SMILES COc1cc(cc(F)c1F)N1CCc2cc(ncc2C1)-c1ncccn1
Show InChI InChI=1S/C19H16F2N4O/c1-26-17-9-14(8-15(20)18(17)21)25-6-3-12-7-16(24-10-13(12)11-25)19-22-4-2-5-23-19/h2,4-5,7-10H,3,6,11H2,1H3
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333099
PNG
(US10196391, Example 99)
Show SMILES COc1cc(F)nc(c1)N1CCc2nc(ncc2C1)-c1ncccn1
Show InChI InChI=1S/C17H15FN6O/c1-25-12-7-14(18)23-15(8-12)24-6-3-13-11(10-24)9-21-17(22-13)16-19-4-2-5-20-16/h2,4-5,7-9H,3,6,10H2,1H3
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333017
PNG
(6-(3,4-difluoro-5-methoxy-phenyl)-2-(2-pyridyl)-7,...)
Show SMILES COc1cc(cc(F)c1F)N1CCc2nc(ncc2C1)-c1ccccn1
Show InChI InChI=1S/C19H16F2N4O/c1-26-17-9-13(8-14(20)18(17)21)25-7-5-15-12(11-25)10-23-19(24-15)16-4-2-3-6-22-16/h2-4,6,8-10H,5,7,11H2,1H3
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333117
PNG
(US10196391, Example 117)
Show SMILES COc1cc(F)cc(c1)N1CCc2nc(ncc2C1)-c1ncccn1
Show InChI InChI=1S/C18H16FN5O/c1-25-15-8-13(19)7-14(9-15)24-6-3-16-12(11-24)10-22-18(23-16)17-20-4-2-5-21-17/h2,4-5,7-10H,3,6,11H2,1H3
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
TBD


(Hepatitis GB virus B)
BDBM333080
PNG
(US10196391, Example 80)
Show SMILES CS(=O)(=O)c1ccc(cc1)N1CCc2nc(nc(O)c2C1)-c1ccccn1
Show InChI InChI=1S/C19H18N4O3S/c1-27(25,26)14-7-5-13(6-8-14)23-11-9-16-15(12-23)19(24)22-18(21-16)17-4-2-3-10-20-17/h2-8,10H,9,11-12H2,1H3,(H,21,22,24)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
The assay employs real-time qPCR (TaqMan) to directly measure extracellular HBV DNA copy number. HepG2.2.15 cells were plated in 96-well microtiter p...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333113
PNG
(US10196391, Example 113)
Show SMILES Clc1cc(Cl)nc(c1)N1CCc2nc(ncc2C1)-c1ncccn1
Show InChI InChI=1S/C16H12Cl2N6/c17-11-6-13(18)23-14(7-11)24-5-2-12-10(9-24)8-21-16(22-12)15-19-3-1-4-20-15/h1,3-4,6-8H,2,5,9H2
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333096
PNG
(US10196391, Example 96)
Show SMILES COc1cc(cc(F)c1F)N1CCc2cc(ncc2C1)-c1ccccn1
Show InChI InChI=1S/C20H17F2N3O/c1-26-19-10-15(9-16(21)20(19)22)25-7-5-13-8-18(24-11-14(13)12-25)17-4-2-3-6-23-17/h2-4,6,8-11H,5,7,12H2,1H3
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333091
PNG
(US10196391, Example 91)
Show SMILES COc1cc(F)cc(c1)N1CCc2nc(ncc2C1)-c1ccccn1
Show InChI InChI=1S/C19H17FN4O/c1-25-16-9-14(20)8-15(10-16)24-7-5-17-13(12-24)11-22-19(23-17)18-4-2-3-6-21-18/h2-4,6,8-11H,5,7,12H2,1H3
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333108
PNG
(US10196391, Example 108)
Show SMILES COc1cc(Cl)nc(c1)N1CCc2nc(ncc2C1)-c1ncccn1
Show InChI InChI=1S/C17H15ClN6O/c1-25-12-7-14(18)23-15(8-12)24-6-3-13-11(10-24)9-21-17(22-13)16-19-4-2-5-20-16/h2,4-5,7-9H,3,6,10H2,1H3
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333077
PNG
(US10196391, Example 77)
Show SMILES COc1cc(cc(F)c1C#N)N1CCc2nc(ncc2C1)-c1ncccn1
Show InChI InChI=1S/C19H15FN6O/c1-27-17-8-13(7-15(20)14(17)9-21)26-6-3-16-12(11-26)10-24-19(25-16)18-22-4-2-5-23-18/h2,4-5,7-8,10H,3,6,11H2,1H3
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333098
PNG
(US10196391, Example 98)
Show SMILES COc1cc(Cl)cc(c1)N1CCc2nc(ncc2C1)-c1ncccn1
Show InChI InChI=1S/C18H16ClN5O/c1-25-15-8-13(19)7-14(9-15)24-6-3-16-12(11-24)10-22-18(23-16)17-20-4-2-5-21-17/h2,4-5,7-10H,3,6,11H2,1H3
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333100
PNG
(US10196391, Example 100)
Show SMILES COc1cc(cc(c1)C(F)(F)F)N1CCc2nc(ncc2C1)-c1ncccn1
Show InChI InChI=1S/C19H16F3N5O/c1-28-15-8-13(19(20,21)22)7-14(9-15)27-6-3-16-12(11-27)10-25-18(26-16)17-23-4-2-5-24-17/h2,4-5,7-10H,3,6,11H2,1H3
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333079
PNG
(US10196391, Example 79)
Show SMILES COc1cc(cc(Cl)c1F)N1CCc2nc(ncc2C1)-c1ncccn1
Show InChI InChI=1S/C18H15ClFN5O/c1-26-15-8-12(7-13(19)16(15)20)25-6-3-14-11(10-25)9-23-18(24-14)17-21-4-2-5-22-17/h2,4-5,7-9H,3,6,10H2,1H3
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333093
PNG
(US10196391, Example 93)
Show SMILES OCCCOc1cc(cc(F)c1F)N1CCc2nc(ncc2C1)-c1ccccn1
Show InChI InChI=1S/C21H20F2N4O2/c22-16-10-15(11-19(20(16)23)29-9-3-8-28)27-7-5-17-14(13-27)12-25-21(26-17)18-4-1-2-6-24-18/h1-2,4,6,10-12,28H,3,5,7-9,13H2
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333021
PNG
(US10196391, Example 21)
Show SMILES CCOc1cc(cc(F)c1F)N1CCc2nc(ncc2C1)-c1ccccn1
Show InChI InChI=1S/C20H18F2N4O/c1-2-27-18-10-14(9-15(21)19(18)22)26-8-6-16-13(12-26)11-24-20(25-16)17-5-3-4-7-23-17/h3-5,7,9-11H,2,6,8,12H2,1H3
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333071
PNG
(6-(3-fluoro-4-methoxy-2-pyridyl)-2-(2-pyridyl)-7,8...)
Show SMILES COc1cc(ncc1F)N1CCc2nc(ncc2C1)-c1ccccn1
Show InChI InChI=1S/C18H16FN5O/c1-25-16-8-17(21-10-13(16)19)24-7-5-14-12(11-24)9-22-18(23-14)15-4-2-3-6-20-15/h2-4,6,8-10H,5,7,11H2,1H3
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333115
PNG
(6-(4-chloro-6-methoxy-2-pyridyl)-2-pyrimidin-2-yl-...)
Show SMILES COc1cc(Cl)cc(n1)N1CCc2nc(ncc2C1)-c1ncccn1
Show InChI InChI=1S/C17H15ClN6O/c1-25-15-8-12(18)7-14(23-15)24-6-3-13-11(10-24)9-21-17(22-13)16-19-4-2-5-20-16/h2,4-5,7-9H,3,6,10H2,1H3
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333111
PNG
(US10196391, Example 111)
Show SMILES COc1cc(F)cc(n1)N1CCc2nc(ncc2C1)-c1ncccn1
Show InChI InChI=1S/C17H15FN6O/c1-25-15-8-12(18)7-14(23-15)24-6-3-13-11(10-24)9-21-17(22-13)16-19-4-2-5-20-16/h2,4-5,7-9H,3,6,10H2,1H3
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333060
PNG
(US10196391, Example 60)
Show SMILES COc1cc(ccc1C#N)N1CCc2nc(ncc2C1)-c1ccccn1
Show InChI InChI=1S/C20H17N5O/c1-26-19-10-16(6-5-14(19)11-21)25-9-7-17-15(13-25)12-23-20(24-17)18-4-2-3-8-22-18/h2-6,8,10,12H,7,9,13H2,1H3
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333033
PNG
(US10196391, Example 33)
Show SMILES [O-][N+](=O)c1ccccc1N1CCc2nc(ncc2C1)-c1ccccn1
Show InChI InChI=1S/C18H15N5O2/c24-23(25)17-7-2-1-6-16(17)22-10-8-14-13(12-22)11-20-18(21-14)15-5-3-4-9-19-15/h1-7,9,11H,8,10,12H2
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333028
PNG
(US10196391, Example 28)
Show SMILES COc1cc(cc(F)c1F)N1CCc2nc(ncc2C1)-c1cnccn1
Show InChI InChI=1S/C18H15F2N5O/c1-26-16-7-12(6-13(19)17(16)20)25-5-2-14-11(10-25)8-23-18(24-14)15-9-21-3-4-22-15/h3-4,6-9H,2,5,10H2,1H3
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333019
PNG
(US10196391, Example 19)
Show SMILES COCCCOc1cc(cc(F)c1F)N1CCc2nc(ncc2C1)-c1ccccn1
Show InChI InChI=1S/C22H22F2N4O2/c1-29-9-4-10-30-20-12-16(11-17(23)21(20)24)28-8-6-18-15(14-28)13-26-22(27-18)19-5-2-3-7-25-19/h2-3,5,7,11-13H,4,6,8-10,14H2,1H3
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333041
PNG
(US10196391, Example 41)
Show SMILES Fc1cc(Br)cc(c1)N1CCc2nc(ncc2C1)-c1ncccn1
Show InChI InChI=1S/C17H13BrFN5/c18-12-6-13(19)8-14(7-12)24-5-2-15-11(10-24)9-22-17(23-15)16-20-3-1-4-21-16/h1,3-4,6-9H,2,5,10H2
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333116
PNG
(6-(2-chloro-6-methoxy-4-pyridyl)-2-pyrimidin-2-yl-...)
Show SMILES COc1cc(cc(Cl)n1)N1CCc2nc(ncc2C1)-c1ncccn1
Show InChI InChI=1S/C17H15ClN6O/c1-25-15-8-12(7-14(18)23-15)24-6-3-13-11(10-24)9-21-17(22-13)16-19-4-2-5-20-16/h2,4-5,7-9H,3,6,10H2,1H3
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333023
PNG
(US10196391, Example 23)
Show SMILES COCCOc1cc(cc(F)c1F)N1CCc2nc(ncc2C1)-c1ccccn1
Show InChI InChI=1S/C21H20F2N4O2/c1-28-8-9-29-19-11-15(10-16(22)20(19)23)27-7-5-17-14(13-27)12-25-21(26-17)18-4-2-3-6-24-18/h2-4,6,10-12H,5,7-9,13H2,1H3
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333112
PNG
(US10196391, Example 112)
Show SMILES COc1cc(cc(F)n1)N1CCc2nc(ncc2C1)-c1ncccn1
Show InChI InChI=1S/C17H15FN6O/c1-25-15-8-12(7-14(18)23-15)24-6-3-13-11(10-24)9-21-17(22-13)16-19-4-2-5-20-16/h2,4-5,7-9H,3,6,10H2,1H3
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333042
PNG
(US10196391, Example 42)
Show SMILES Fc1cc(cc(c1)N1CCc2nc(ncc2C1)-c1ncccn1)C1CC1
Show InChI InChI=1S/C20H18FN5/c21-16-8-14(13-2-3-13)9-17(10-16)26-7-4-18-15(12-26)11-24-20(25-18)19-22-5-1-6-23-19/h1,5-6,8-11,13H,2-4,7,12H2
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333094
PNG
(US10196391, Example 94)
Show SMILES OCCOc1cc(cc(F)c1F)N1CCc2nc(ncc2C1)-c1ccccn1
Show InChI InChI=1S/C20H18F2N4O2/c21-15-9-14(10-18(19(15)22)28-8-7-27)26-6-4-16-13(12-26)11-24-20(25-16)17-3-1-2-5-23-17/h1-3,5,9-11,27H,4,6-8,12H2
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333040
PNG
(US10196391, Example 40)
Show SMILES Cc1cc(F)cc(c1)N1CCc2nc(ncc2C1)-c1ccccn1
Show InChI InChI=1S/C19H17FN4/c1-13-8-15(20)10-16(9-13)24-7-5-17-14(12-24)11-22-19(23-17)18-4-2-3-6-21-18/h2-4,6,8-11H,5,7,12H2,1H3
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333101
PNG
(US10196391, Example 101)
Show SMILES Fc1cc(cc(c1)N1CCc2nc(ncc2C1)-c1ncccn1)C#N
Show InChI InChI=1S/C18H13FN6/c19-14-6-12(9-20)7-15(8-14)25-5-2-16-13(11-25)10-23-18(24-16)17-21-3-1-4-22-17/h1,3-4,6-8,10H,2,5,11H2
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333022
PNG
(US10196391, Example 22)
Show SMILES CCCOc1cc(cc(F)c1F)N1CCc2nc(ncc2C1)-c1ccccn1
Show InChI InChI=1S/C21H20F2N4O/c1-2-9-28-19-11-15(10-16(22)20(19)23)27-8-6-17-14(13-27)12-25-21(26-17)18-5-3-4-7-24-18/h3-5,7,10-12H,2,6,8-9,13H2,1H3
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333034
PNG
(US10196391, Example 34)
Show SMILES COc1cc(ccc1N1CCc2nc(ncc2C1)-c1ccccn1)[N+]([O-])=O
Show InChI InChI=1S/C19H17N5O3/c1-27-18-10-14(24(25)26)5-6-17(18)23-9-7-15-13(12-23)11-21-19(22-15)16-4-2-3-8-20-16/h2-6,8,10-11H,7,9,12H2,1H3
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333090
PNG
(US10196391, Example 90)
Show SMILES COc1cc(ccc1F)N1CCc2nc(ncc2C1)-c1ccccn1
Show InChI InChI=1S/C19H17FN4O/c1-25-18-10-14(5-6-15(18)20)24-9-7-16-13(12-24)11-22-19(23-16)17-4-2-3-8-21-17/h2-6,8,10-11H,7,9,12H2,1H3
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333069
PNG
(6-(5-chloro-2-methoxy-pyrimidin-4-yl)-2-(2-pyridyl...)
Show SMILES COc1ncc(Cl)c(n1)N1CCc2nc(ncc2C1)-c1ccccn1
Show InChI InChI=1S/C17H15ClN6O/c1-25-17-21-9-12(18)16(23-17)24-7-5-13-11(10-24)8-20-15(22-13)14-4-2-3-6-19-14/h2-4,6,8-9H,5,7,10H2,1H3
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333013
PNG
(US10196391, Example 13)
Show SMILES Fc1cc(F)cc(c1)N1CCc2nc(ncc2C1)-c1ccccn1
Show InChI InChI=1S/C18H14F2N4/c19-13-7-14(20)9-15(8-13)24-6-4-16-12(11-24)10-22-18(23-16)17-3-1-2-5-21-17/h1-3,5,7-10H,4,6,11H2
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333049
PNG
(US10196391, Example 49)
Show SMILES Clc1ccc(cc1Cl)N1CCc2nc(ncc2C1)-c1ccccn1
Show InChI InChI=1S/C18H14Cl2N4/c19-14-5-4-13(9-15(14)20)24-8-6-16-12(11-24)10-22-18(23-16)17-3-1-2-7-21-17/h1-5,7,9-10H,6,8,11H2
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333114
PNG
(US10196391, Example 114)
Show SMILES Clc1cc(cc(Cl)n1)N1CCc2nc(ncc2C1)-c1ncccn1
Show InChI InChI=1S/C16H12Cl2N6/c17-13-6-11(7-14(18)23-13)24-5-2-12-10(9-24)8-21-16(22-12)15-19-3-1-4-20-15/h1,3-4,6-8H,2,5,9H2
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333055
PNG
(US10196391, Example 55)
Show SMILES CCCOc1ccc(cc1F)N1CCc2nc(ncc2C1)-c1ccccn1
Show InChI InChI=1S/C21H21FN4O/c1-2-11-27-20-7-6-16(12-17(20)22)26-10-8-18-15(14-26)13-24-21(25-18)19-5-3-4-9-23-19/h3-7,9,12-13H,2,8,10-11,14H2,1H3
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333104
PNG
(US10196391, Example 104)
Show SMILES Fc1cc(cc(c1)C(=O)NCC(F)(F)F)N1CCc2nc(ncc2C1)-c1ncccn1
Show InChI InChI=1S/C20H16F4N6O/c21-14-6-12(19(31)28-11-20(22,23)24)7-15(8-14)30-5-2-16-13(10-30)9-27-18(29-16)17-25-3-1-4-26-17/h1,3-4,6-9H,2,5,10-11H2,(H,28,31)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333062
PNG
(US10196391, Example 62)
Show SMILES COc1cc(ccc1Cl)N1CCc2nc(ncc2C1)-c1ccccn1
Show InChI InChI=1S/C19H17ClN4O/c1-25-18-10-14(5-6-15(18)20)24-9-7-16-13(12-24)11-22-19(23-16)17-4-2-3-8-21-17/h2-6,8,10-11H,7,9,12H2,1H3
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333106
PNG
(US10196391, Example 106)
Show SMILES COCCCNC(=O)c1cc(F)cc(c1)N1CCc2nc(ncc2C1)-c1ncccn1
Show InChI InChI=1S/C22H23FN6O2/c1-31-9-3-7-26-22(30)15-10-17(23)12-18(11-15)29-8-4-19-16(14-29)13-27-21(28-19)20-24-5-2-6-25-20/h2,5-6,10-13H,3-4,7-9,14H2,1H3,(H,26,30)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333048
PNG
(US10196391, Example 48)
Show SMILES CC1CN(Cc2cnc(nc12)-c1ccccn1)c1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C19H17N5O2/c1-13-11-23(15-5-7-16(8-6-15)24(25)26)12-14-10-21-19(22-18(13)14)17-4-2-3-9-20-17/h2-10,13H,11-12H2,1H3
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333072
PNG
(US10196391, Example 72)
Show SMILES COc1nc(ccc1F)N1CCc2nc(ncc2C1)-c1ncccn1
Show InChI InChI=1S/C17H15FN6O/c1-25-17-12(18)3-4-14(23-17)24-8-5-13-11(10-24)9-21-16(22-13)15-19-6-2-7-20-15/h2-4,6-7,9H,5,8,10H2,1H3
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333110
PNG
(6-(4,6-difluoro-2-pyridyl)-2-pyrimidin-2-yl-7,8-di...)
Show SMILES Fc1cc(F)nc(c1)N1CCc2nc(ncc2C1)-c1ncccn1
Show InChI InChI=1S/C16H12F2N6/c17-11-6-13(18)23-14(7-11)24-5-2-12-10(9-24)8-21-16(22-12)15-19-3-1-4-20-15/h1,3-4,6-8H,2,5,9H2
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333068
PNG
(6-(5-chloro-4-methoxy-pyrimidin-2-yl)-2-(2-pyridyl...)
Show SMILES COc1nc(ncc1Cl)N1CCc2nc(ncc2C1)-c1ccccn1
Show InChI InChI=1S/C17H15ClN6O/c1-25-16-12(18)9-21-17(23-16)24-7-5-13-11(10-24)8-20-15(22-13)14-4-2-3-6-19-14/h2-4,6,8-9H,5,7,10H2,1H3
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333076
PNG
(US10196391, Example 76)
Show SMILES COc1cc(cc(c1)N1CCc2nc(ncc2C1)-c1ncccn1)C#N
Show InChI InChI=1S/C19H16N6O/c1-26-16-8-13(10-20)7-15(9-16)25-6-3-17-14(12-25)11-23-19(24-17)18-21-4-2-5-22-18/h2,4-5,7-9,11H,3,6,12H2,1H3
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333036
PNG
(US10196391, Example 36)
Show SMILES Clc1ccc(nc1)N1CCc2nc(ncc2C1)-c1ccccn1
Show InChI InChI=1S/C17H14ClN5/c18-13-4-5-16(20-10-13)23-8-6-14-12(11-23)9-21-17(22-14)15-3-1-2-7-19-15/h1-5,7,9-10H,6,8,11H2
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333070
PNG
(6-(5-fluoro-4-methoxy-2-pyridyl)-2-(2-pyridyl)-7,8...)
Show SMILES COc1ccnc(N2CCc3nc(ncc3C2)-c2ccccn2)c1F
Show InChI InChI=1S/C18H16FN5O/c1-25-15-5-8-21-18(16(15)19)24-9-6-13-12(11-24)10-22-17(23-13)14-4-2-3-7-20-14/h2-5,7-8,10H,6,9,11H2,1H3
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333053
PNG
(US10196391, Example 53)
Show SMILES Fc1cc(ccc1OCc1ccccc1)N1CCc2nc(ncc2C1)-c1ccccn1
Show InChI InChI=1S/C25H21FN4O/c26-21-14-20(9-10-24(21)31-17-18-6-2-1-3-7-18)30-13-11-22-19(16-30)15-28-25(29-22)23-8-4-5-12-27-23/h1-10,12,14-15H,11,13,16-17H2
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333064
PNG
(US10196391, Example 64)
Show SMILES Fc1cc(cc(F)c1OCc1ccccc1)N1CCc2nc(ncc2C1)-c1ccccn1
Show InChI InChI=1S/C25H20F2N4O/c26-20-12-19(13-21(27)24(20)32-16-17-6-2-1-3-7-17)31-11-9-22-18(15-31)14-29-25(30-22)23-8-4-5-10-28-23/h1-8,10,12-14H,9,11,15-16H2
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333056
PNG
(US10196391, Example 56)
Show SMILES COCCCOc1ccc(cc1F)N1CCc2nc(ncc2C1)-c1ccccn1
Show InChI InChI=1S/C22H23FN4O2/c1-28-11-4-12-29-21-7-6-17(13-18(21)23)27-10-8-19-16(15-27)14-25-22(26-19)20-5-2-3-9-24-20/h2-3,5-7,9,13-14H,4,8,10-12,15H2,1H3
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333043
PNG
(US10196391, Example 43)
Show SMILES FC(F)(F)Oc1cccc(c1)N1CCc2nc(ncc2C1)-c1ncccn1
Show InChI InChI=1S/C18H14F3N5O/c19-18(20,21)27-14-4-1-3-13(9-14)26-8-5-15-12(11-26)10-24-17(25-15)16-22-6-2-7-23-16/h1-4,6-7,9-10H,5,8,11H2
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333024
PNG
(US10196391, Example 24)
Show SMILES COc1ccnc(c1)-c1ncc2CN(CCc2n1)c1cc(F)c(F)c(OC)c1
Show InChI InChI=1S/C20H18F2N4O2/c1-27-14-3-5-23-17(9-14)20-24-10-12-11-26(6-4-16(12)25-20)13-7-15(21)19(22)18(8-13)28-2/h3,5,7-10H,4,6,11H2,1-2H3
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333063
PNG
(US10196391, Example 63)
Show SMILES FC(F)Oc1cccc(c1)N1CCc2nc(ncc2C1)-c1ncccn1
Show InChI InChI=1S/C18H15F2N5O/c19-18(20)26-14-4-1-3-13(9-14)25-8-5-15-12(11-25)10-23-17(24-15)16-21-6-2-7-22-16/h1-4,6-7,9-10,18H,5,8,11H2
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333073
PNG
(US10196391, Example 73)
Show SMILES COc1cc(OC)cc(c1)N1CCc2nc(ncc2C1)-c1ncccn1
Show InChI InChI=1S/C19H19N5O2/c1-25-15-8-14(9-16(10-15)26-2)24-7-4-17-13(12-24)11-22-19(23-17)18-20-5-3-6-21-18/h3,5-6,8-11H,4,7,12H2,1-2H3
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333052
PNG
(US10196391, Example 52)
Show SMILES Fc1cc(ccc1Br)N1CCc2nc(ncc2C1)-c1ccccn1
Show InChI InChI=1S/C18H14BrFN4/c19-14-5-4-13(9-15(14)20)24-8-6-16-12(11-24)10-22-18(23-16)17-3-1-2-7-21-17/h1-5,7,9-10H,6,8,11H2
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333075
PNG
(US10196391, Example 75)
Show SMILES COc1ccc2ccc(cc2n1)N1CCc2nc(ncc2C1)-c1ncccn1
Show InChI InChI=1S/C21H18N6O/c1-28-19-6-4-14-3-5-16(11-18(14)25-19)27-10-7-17-15(13-27)12-24-21(26-17)20-22-8-2-9-23-20/h2-6,8-9,11-12H,7,10,13H2,1H3
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333074
PNG
(US10196391, Example 74)
Show SMILES COc1ccc2ccc(nc2c1)N1CCc2nc(ncc2C1)-c1ncccn1
Show InChI InChI=1S/C21H18N6O/c1-28-16-5-3-14-4-6-19(25-18(14)11-16)27-10-7-17-15(13-27)12-24-21(26-17)20-22-8-2-9-23-20/h2-6,8-9,11-12H,7,10,13H2,1H3
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333057
PNG
(US10196391, Example 57)
Show SMILES COCCOc1ccc(cc1OC)N1CCc2nc(ncc2C1)-c1ccccn1
Show InChI InChI=1S/C22H24N4O3/c1-27-11-12-29-20-7-6-17(13-21(20)28-2)26-10-8-18-16(15-26)14-24-22(25-18)19-5-3-4-9-23-19/h3-7,9,13-14H,8,10-12,15H2,1-2H3
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333010
PNG
(US10196391, Example 10)
Show SMILES Fc1ccc(cc1F)N1CCc2nc(ncc2C1)-c1ccccn1
Show InChI InChI=1S/C18H14F2N4/c19-14-5-4-13(9-15(14)20)24-8-6-16-12(11-24)10-22-18(23-16)17-3-1-2-7-21-17/h1-5,7,9-10H,6,8,11H2
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333103
PNG
(US10196391, Example 103)
Show SMILES CNC(=O)c1cc(F)cc(c1)N1CCc2nc(ncc2C1)-c1ncccn1
Show InChI InChI=1S/C19H17FN6O/c1-21-19(27)12-7-14(20)9-15(8-12)26-6-3-16-13(11-26)10-24-18(25-16)17-22-4-2-5-23-17/h2,4-5,7-10H,3,6,11H2,1H3,(H,21,27)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333020
PNG
(US10196391, Example 20)
Show SMILES Fc1cc(cc(OCc2ccccc2)c1F)N1CCc2nc(ncc2C1)-c1ccccn1
Show InChI InChI=1S/C25H20F2N4O/c26-20-12-19(13-23(24(20)27)32-16-17-6-2-1-3-7-17)31-11-9-21-18(15-31)14-29-25(30-21)22-8-4-5-10-28-22/h1-8,10,12-14H,9,11,15-16H2
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333092
PNG
(US10196391, Example 92)
Show SMILES COc1cccc(c1)N1CCc2nc(ncc2C1)-c1ccccn1
Show InChI InChI=1S/C19H18N4O/c1-24-16-6-4-5-15(11-16)23-10-8-17-14(13-23)12-21-19(22-17)18-7-2-3-9-20-18/h2-7,9,11-12H,8,10,13H2,1H3
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333061
PNG
(US10196391, Example 61)
Show SMILES COc1ccc(N2CCc3nc(ncc3C2)-c2ccccn2)c(F)c1F
Show InChI InChI=1S/C19H16F2N4O/c1-26-16-6-5-15(17(20)18(16)21)25-9-7-13-12(11-25)10-23-19(24-13)14-4-2-3-8-22-14/h2-6,8,10H,7,9,11H2,1H3
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333027
PNG
(US10196391, Example 27)
Show SMILES COc1cc(F)c(F)cc1N1CCc2nc(ncc2C1)-c1ccccn1
Show InChI InChI=1S/C19H16F2N4O/c1-26-18-9-14(21)13(20)8-17(18)25-7-5-15-12(11-25)10-23-19(24-15)16-4-2-3-6-22-16/h2-4,6,8-10H,5,7,11H2,1H3
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333045
PNG
(US10196391, Example 45)
Show SMILES Clc1ccc(cc1)N1CCc2nc(ncc2C1)-c1ccccn1
Show InChI InChI=1S/C18H15ClN4/c19-14-4-6-15(7-5-14)23-10-8-16-13(12-23)11-21-18(22-16)17-3-1-2-9-20-17/h1-7,9,11H,8,10,12H2
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333082
PNG
(US10196391, Example 82)
Show SMILES CCOc1nc(nc2CCN(Cc12)c1ccc(cc1)S(C)(=O)=O)-c1ccccn1
Show InChI InChI=1S/C21H22N4O3S/c1-3-28-21-17-14-25(15-7-9-16(10-8-15)29(2,26)27)13-11-18(17)23-20(24-21)19-6-4-5-12-22-19/h4-10,12H,3,11,13-14H2,1-2H3
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333054
PNG
(US10196391, Example 54)
Show SMILES CCOc1ccc(cc1F)N1CCc2nc(ncc2C1)-c1ccccn1
Show InChI InChI=1S/C20H19FN4O/c1-2-26-19-7-6-15(11-16(19)21)25-10-8-17-14(13-25)12-23-20(24-17)18-5-3-4-9-22-18/h3-7,9,11-12H,2,8,10,13H2,1H3
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333109
PNG
(6-(2,6-difluoro-4-pyridyl)-2-pyrimidin-2-yl-7,8-di...)
Show SMILES Fc1cc(cc(F)n1)N1CCc2nc(ncc2C1)-c1ncccn1
Show InChI InChI=1S/C16H12F2N6/c17-13-6-11(7-14(18)23-13)24-5-2-12-10(9-24)8-21-16(22-12)15-19-3-1-4-20-15/h1,3-4,6-8H,2,5,9H2
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333029
PNG
(US10196391, Example 29)
Show SMILES COc1cc(cc(F)c1F)N1CCc2nc(ncc2C1)-c1ccncn1
Show InChI InChI=1S/C18H15F2N5O/c1-26-16-7-12(6-13(19)17(16)20)25-5-3-14-11(9-25)8-22-18(24-14)15-2-4-21-10-23-15/h2,4,6-8,10H,3,5,9H2,1H3
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333008
PNG
(US10196391, Example 8)
Show SMILES CNS(=O)(=O)c1ccc(cc1)N1CCc2nc(ncc2C1)-c1ccccn1
Show InChI InChI=1S/C19H19N5O2S/c1-20-27(25,26)16-7-5-15(6-8-16)24-11-9-17-14(13-24)12-22-19(23-17)18-4-2-3-10-21-18/h2-8,10,12,20H,9,11,13H2,1H3
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333001
PNG
(US10196391, Example 1)
Show SMILES CS(=O)(=O)c1ccc(cc1)N1CCc2nc(ncc2C1)-c1ccccn1
Show InChI InChI=1S/C19H18N4O2S/c1-26(24,25)16-7-5-15(6-8-16)23-11-9-17-14(13-23)12-21-19(22-17)18-4-2-3-10-20-18/h2-8,10,12H,9,11,13H2,1H3
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333037
PNG
(US10196391, Example 37)
Show SMILES C1Cc2nc(ncc2CN1c1ncccn1)-c1ccccn1
Show InChI InChI=1S/C16H14N6/c1-2-6-17-14(4-1)15-20-10-12-11-22(9-5-13(12)21-15)16-18-7-3-8-19-16/h1-4,6-8,10H,5,9,11H2
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333118
PNG
(US10196391, Example 118)
Show SMILES Fc1cc(OC(F)(F)F)cc(c1)N1CCc2nc(ncc2C1)-c1ncccn1
Show InChI InChI=1S/C18H13F4N5O/c19-12-6-13(8-14(7-12)28-18(20,21)22)27-5-2-15-11(10-27)9-25-17(26-15)16-23-3-1-4-24-16/h1,3-4,6-9H,2,5,10H2
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333007
PNG
(US10196391, Example 7)
Show SMILES CCC1CN(Cc2cnc(nc12)-c1ccccn1)c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C21H22N4O2S/c1-3-15-13-25(17-7-9-18(10-8-17)28(2,26)27)14-16-12-23-21(24-20(15)16)19-6-4-5-11-22-19/h4-12,15H,3,13-14H2,1-2H3
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333051
PNG
(US10196391, Example 51)
Show SMILES Fc1ccc(cc1Br)N1CCc2nc(ncc2C1)-c1ccccn1
Show InChI InChI=1S/C18H14BrFN4/c19-14-9-13(4-5-15(14)20)24-8-6-16-12(11-24)10-22-18(23-16)17-3-1-2-7-21-17/h1-5,7,9-10H,6,8,11H2
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333080
PNG
(US10196391, Example 80)
Show SMILES CS(=O)(=O)c1ccc(cc1)N1CCc2nc(nc(O)c2C1)-c1ccccn1
Show InChI InChI=1S/C19H18N4O3S/c1-27(25,26)14-7-5-13(6-8-14)23-11-9-16-15(12-23)19(24)22-18(21-16)17-4-2-3-10-20-17/h2-8,10H,9,11-12H2,1H3,(H,21,22,24)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333119
PNG
(US10196391, Example 119)
Show SMILES C1Cc2nc(ncc2CN1c1nccs1)-c1ncccn1
Show InChI InChI=1S/C14H12N6S/c1-3-15-12(16-4-1)13-18-8-10-9-20(6-2-11(10)19-13)14-17-5-7-21-14/h1,3-5,7-8H,2,6,9H2
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333089
PNG
(US10196391, Example 89)
Show SMILES CS(=O)(=O)c1ccc(cc1)N1CCc2nc(ccc2C1)-c1ccccn1
Show InChI InChI=1S/C20H19N3O2S/c1-26(24,25)17-8-6-16(7-9-17)23-13-11-18-15(14-23)5-10-20(22-18)19-4-2-3-12-21-19/h2-10,12H,11,13-14H2,1H3
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333107
PNG
(US10196391, Example 107)
Show SMILES OCCCCCNC(=O)c1cc(F)cc(c1)N1CCc2nc(ncc2C1)-c1ncccn1
Show InChI InChI=1S/C23H25FN6O2/c24-18-11-16(23(32)27-6-2-1-3-10-31)12-19(13-18)30-9-5-20-17(15-30)14-28-22(29-20)21-25-7-4-8-26-21/h4,7-8,11-14,31H,1-3,5-6,9-10,15H2,(H,27,32)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333067
PNG
(US10196391, Example 67)
Show SMILES CCCCOc1cc(ccc1C(O)=O)N1CCc2nc(ncc2C1)-c1ccccn1
Show InChI InChI=1S/C23H24N4O3/c1-2-3-12-30-21-13-17(7-8-18(21)23(28)29)27-11-9-19-16(15-27)14-25-22(26-19)20-6-4-5-10-24-20/h4-8,10,13-14H,2-3,9,11-12,15H2,1H3,(H,28,29)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333035
PNG
(US10196391, Example 35)
Show SMILES C1Cc2nc(ncc2CN1c1ccccn1)-c1ccccn1
Show InChI InChI=1S/C17H15N5/c1-3-8-18-15(5-1)17-20-11-13-12-22(10-7-14(13)21-17)16-6-2-4-9-19-16/h1-6,8-9,11H,7,10,12H2
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333085
PNG
(US10196391, Example 85)
Show SMILES CCCc1nc(nc2CCN(Cc12)c1ccc(cc1)S(C)(=O)=O)-c1ccccn1
Show InChI InChI=1S/C22H24N4O2S/c1-3-6-19-18-15-26(16-8-10-17(11-9-16)29(2,27)28)14-12-20(18)25-22(24-19)21-7-4-5-13-23-21/h4-5,7-11,13H,3,6,12,14-15H2,1-2H3
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333084
PNG
(US10196391, Example 84)
Show SMILES C\C=C\c1nc(nc2CCN(Cc12)c1ccc(cc1)S(C)(=O)=O)-c1ccccn1
Show InChI InChI=1S/C22H22N4O2S/c1-3-6-19-18-15-26(16-8-10-17(11-9-16)29(2,27)28)14-12-20(18)25-22(24-19)21-7-4-5-13-23-21/h3-11,13H,12,14-15H2,1-2H3/b6-3+
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333046
PNG
(US10196391, Example 46)
Show SMILES C(Oc1ccc(cc1)N1CCc2nc(ncc2C1)-c1ccccn1)c1ccccc1
Show InChI InChI=1S/C25H22N4O/c1-2-6-19(7-3-1)18-30-22-11-9-21(10-12-22)29-15-13-23-20(17-29)16-27-25(28-23)24-8-4-5-14-26-24/h1-12,14,16H,13,15,17-18H2
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333059
PNG
(US10196391, Example 59)
Show SMILES COc1ccc(cc1OC)N1CCc2nc(ncc2C1)-c1ccccn1
Show InChI InChI=1S/C20H20N4O2/c1-25-18-7-6-15(11-19(18)26-2)24-10-8-16-14(13-24)12-22-20(23-16)17-5-3-4-9-21-17/h3-7,9,11-12H,8,10,13H2,1-2H3
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333039
PNG
(US10196391, Example 39)
Show SMILES C1Cc2nc(ncc2CN1c1cccnc1)-c1ccccn1
Show InChI InChI=1S/C17H15N5/c1-2-8-19-16(5-1)17-20-10-13-12-22(9-6-15(13)21-17)14-4-3-7-18-11-14/h1-5,7-8,10-11H,6,9,12H2
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333003
PNG
(US10196391, Example 3)
Show SMILES Cc1ccc(nc1)-c1ncc2CN(CCc2n1)c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C20H20N4O2S/c1-14-3-8-19(21-11-14)20-22-12-15-13-24(10-9-18(15)23-20)16-4-6-17(7-5-16)27(2,25)26/h3-8,11-12H,9-10,13H2,1-2H3
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333015
PNG
(US10196391, Example 15)
Show SMILES COC(=O)c1ccc(cc1F)N1CCc2nc(ncc2C1)-c1ccccn1
Show InChI InChI=1S/C20H17FN4O2/c1-27-20(26)15-6-5-14(10-16(15)21)25-9-7-17-13(12-25)11-23-19(24-17)18-4-2-3-8-22-18/h2-6,8,10-11H,7,9,12H2,1H3
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333030
PNG
(US10196391, Example 30)
Show SMILES COc1c(F)c(F)ccc1N1CCc2nc(ncc2C1)-c1ncccn1
Show InChI InChI=1S/C18H15F2N5O/c1-26-16-14(4-3-12(19)15(16)20)25-8-5-13-11(10-25)9-23-18(24-13)17-21-6-2-7-22-17/h2-4,6-7,9H,5,8,10H2,1H3
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n/an/a 9.49E+3n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333014
PNG
(US10196391, Example 14)
Show SMILES Fc1ccc(N2CCc3nc(ncc3C2)-c2ccccn2)c(F)c1
Show InChI InChI=1S/C18H14F2N4/c19-13-4-5-17(14(20)9-13)24-8-6-15-12(11-24)10-22-18(23-15)16-3-1-2-7-21-16/h1-5,7,9-10H,6,8,11H2
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333032
PNG
(US10196391, Example 32)
Show SMILES OC(=O)c1ccc(cc1)N1CCc2nc(ncc2C1)-c1ccccn1
Show InChI InChI=1S/C19H16N4O2/c24-19(25)13-4-6-15(7-5-13)23-10-8-16-14(12-23)11-21-18(22-16)17-3-1-2-9-20-17/h1-7,9,11H,8,10,12H2,(H,24,25)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333002
PNG
(US10196391, Example 2)
Show SMILES CS(=O)(=O)c1ccc(cc1)N1CCc2nc(ncc2C1)-c1ccc(F)cn1
Show InChI InChI=1S/C19H17FN4O2S/c1-27(25,26)16-5-3-15(4-6-16)24-9-8-17-13(12-24)10-22-19(23-17)18-7-2-14(20)11-21-18/h2-7,10-11H,8-9,12H2,1H3
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333087
PNG
(US10196391, Example 87)
Show SMILES Cc1nc(nc2CCN(Cc12)c1ccc(cc1)S(C)(=O)=O)-c1ccccn1
Show InChI InChI=1S/C20H20N4O2S/c1-14-17-13-24(15-6-8-16(9-7-15)27(2,25)26)12-10-18(17)23-20(22-14)19-5-3-4-11-21-19/h3-9,11H,10,12-13H2,1-2H3
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333081
PNG
(US10196391, Example 81)
Show SMILES COc1nc(nc2CCN(Cc12)c1ccc(cc1)S(C)(=O)=O)-c1ccccn1
Show InChI InChI=1S/C20H20N4O3S/c1-27-20-16-13-24(14-6-8-15(9-7-14)28(2,25)26)12-10-17(16)22-19(23-20)18-5-3-4-11-21-18/h3-9,11H,10,12-13H2,1-2H3
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333047
PNG
(US10196391, Example 47)
Show SMILES Cc1ccc(cc1)N1CCc2nc(ncc2C1)-c1ccccn1
Show InChI InChI=1S/C19H18N4/c1-14-5-7-16(8-6-14)23-11-9-17-15(13-23)12-21-19(22-17)18-4-2-3-10-20-18/h2-8,10,12H,9,11,13H2,1H3
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333102
PNG
(US10196391, Example 102)
Show SMILES COC(=O)c1cc(F)cc(c1)N1CCc2nc(ncc2C1)-c1ncccn1
Show InChI InChI=1S/C19H16FN5O2/c1-27-19(26)12-7-14(20)9-15(8-12)25-6-3-16-13(11-25)10-23-18(24-16)17-21-4-2-5-22-17/h2,4-5,7-10H,3,6,11H2,1H3
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333066
PNG
(US10196391, Example 66)
Show SMILES CCOc1cc(ccc1C(O)=O)N1CCc2nc(ncc2C1)-c1ccccn1
Show InChI InChI=1S/C21H20N4O3/c1-2-28-19-11-15(6-7-16(19)21(26)27)25-10-8-17-14(13-25)12-23-20(24-17)18-5-3-4-9-22-18/h3-7,9,11-12H,2,8,10,13H2,1H3,(H,26,27)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333012
PNG
(US10196391, Example 12)
Show SMILES FC(F)(F)S(=O)(=O)c1ccc(cc1)N1CCc2nc(ncc2C1)-c1ccccn1
Show InChI InChI=1S/C19H15F3N4O2S/c20-19(21,22)29(27,28)15-6-4-14(5-7-15)26-10-8-16-13(12-26)11-24-18(25-16)17-3-1-2-9-23-17/h1-7,9,11H,8,10,12H2
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333016
PNG
(US10196391, Example 16 | methyl 5-bromo-2-[2-(2-py...)
Show SMILES COC(=O)c1cc(Br)ccc1N1CCc2nc(ncc2C1)-c1ccccn1
Show InChI InChI=1S/C20H17BrN4O2/c1-27-20(26)15-10-14(21)5-6-18(15)25-9-7-16-13(12-25)11-23-19(24-16)17-4-2-3-8-22-17/h2-6,8,10-11H,7,9,12H2,1H3
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333025
PNG
(US10196391, Example 25)
Show SMILES COc1cccc(n1)-c1ncc2CN(CCc2n1)c1cc(F)c(F)c(OC)c1
Show InChI InChI=1S/C20H18F2N4O2/c1-27-17-9-13(8-14(21)19(17)22)26-7-6-15-12(11-26)10-23-20(25-15)16-4-3-5-18(24-16)28-2/h3-5,8-10H,6-7,11H2,1-2H3
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333097
PNG
(US10196391, Example 97)
Show SMILES COc1cc(cc(F)c1F)N1CCc2nc(ccc2C1)-c1ncccn1
Show InChI InChI=1S/C19H16F2N4O/c1-26-17-10-13(9-14(20)18(17)21)25-8-5-15-12(11-25)3-4-16(24-15)19-22-6-2-7-23-19/h2-4,6-7,9-10H,5,8,11H2,1H3
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333009
PNG
(US10196391, Example 9)
Show SMILES CN(C)S(=O)(=O)c1ccc(cc1)N1CCc2nc(ncc2C1)-c1ccccn1
Show InChI InChI=1S/C20H21N5O2S/c1-24(2)28(26,27)17-8-6-16(7-9-17)25-12-10-18-15(14-25)13-22-20(23-18)19-5-3-4-11-21-19/h3-9,11,13H,10,12,14H2,1-2H3
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333031
PNG
(US10196391, Example 31)
Show SMILES CCOC(=O)c1ccc(cc1)N1CCc2nc(ncc2C1)-c1ccccn1
Show InChI InChI=1S/C21H20N4O2/c1-2-27-21(26)15-6-8-17(9-7-15)25-12-10-18-16(14-25)13-23-20(24-18)19-5-3-4-11-22-19/h3-9,11,13H,2,10,12,14H2,1H3
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333011
PNG
(US10196391, Example 11)
Show SMILES CS(=O)(=O)c1cccc(c1)N1CCc2nc(ncc2C1)-c1ccccn1
Show InChI InChI=1S/C19H18N4O2S/c1-26(24,25)16-6-4-5-15(11-16)23-10-8-17-14(13-23)12-21-19(22-17)18-7-2-3-9-20-18/h2-7,9,11-12H,8,10,13H2,1H3
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333038
PNG
(US10196391, Example 38)
Show SMILES Fc1ccc(N2CCc3nc(ncc3C2)-c2ccccn2)c(OCc2ccccc2)c1
Show InChI InChI=1S/C25H21FN4O/c26-20-9-10-23(24(14-20)31-17-18-6-2-1-3-7-18)30-13-11-21-19(16-30)15-28-25(29-21)22-8-4-5-12-27-22/h1-10,12,14-15H,11,13,16-17H2
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333004
PNG
(US10196391, Example 4)
Show SMILES Cc1cccnc1-c1ncc2CN(CCc2n1)c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C20H20N4O2S/c1-14-4-3-10-21-19(14)20-22-12-15-13-24(11-9-18(15)23-20)16-5-7-17(8-6-16)27(2,25)26/h3-8,10,12H,9,11,13H2,1-2H3
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333105
PNG
(US10196391, Example 105)
Show SMILES NC(=O)c1cc(F)cc(c1)N1CCc2nc(ncc2C1)-c1ncccn1
Show InChI InChI=1S/C18H15FN6O/c19-13-6-11(16(20)26)7-14(8-13)25-5-2-15-12(10-25)9-23-18(24-15)17-21-3-1-4-22-17/h1,3-4,6-9H,2,5,10H2,(H2,20,26)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333065
PNG
(US10196391, Example 65)
Show SMILES COc1cc(ccc1C(O)=O)N1CCc2nc(ncc2C1)-c1ccccn1
Show InChI InChI=1S/C20H18N4O3/c1-27-18-10-14(5-6-15(18)20(25)26)24-9-7-16-13(12-24)11-22-19(23-16)17-4-2-3-8-21-17/h2-6,8,10-11H,7,9,12H2,1H3,(H,25,26)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333006
PNG
(US10196391, Example 6)
Show SMILES CS(=O)(=O)c1ccc(cc1)N1CCc2nc(ncc2C1)-c1ccc(Cl)cn1
Show InChI InChI=1S/C19H17ClN4O2S/c1-27(25,26)16-5-3-15(4-6-16)24-9-8-17-13(12-24)10-22-19(23-17)18-7-2-14(20)11-21-18/h2-7,10-11H,8-9,12H2,1H3
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333044
PNG
(US10196391, Example 44)
Show SMILES COCCCOc1ccc(cc1OC)N1CCc2nc(ncc2C1)-c1ccccn1
Show InChI InChI=1S/C23H26N4O3/c1-28-12-5-13-30-21-8-7-18(14-22(21)29-2)27-11-9-19-17(16-27)15-25-23(26-19)20-6-3-4-10-24-20/h3-4,6-8,10,14-15H,5,9,11-13,16H2,1-2H3
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333078
PNG
(US10196391, Example 78)
Show SMILES COc1cc(cc(F)c1Cl)N1CCc2nc(ncc2C1)-c1ncccn1
Show InChI InChI=1S/C18H15ClFN5O/c1-26-15-8-12(7-13(20)16(15)19)25-6-3-14-11(10-25)9-23-18(24-14)17-21-4-2-5-22-17/h2,4-5,7-9H,3,6,10H2,1H3
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333083
PNG
(US10196391, Example 83)
Show SMILES CS(=O)(=O)c1ccc(cc1)N1CCc2nc(nc(OCc3ccccc3)c2C1)-c1ccccn1
Show InChI InChI=1S/C26H24N4O3S/c1-34(31,32)21-12-10-20(11-13-21)30-16-14-23-22(17-30)26(33-18-19-7-3-2-4-8-19)29-25(28-23)24-9-5-6-15-27-24/h2-13,15H,14,16-18H2,1H3
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333058
PNG
(US10196391, Example 58)
Show SMILES COCCOc1cc(ccc1OC)N1CCc2nc(ncc2C1)-c1ccccn1
Show InChI InChI=1S/C22H24N4O3/c1-27-11-12-29-21-13-17(6-7-20(21)28-2)26-10-8-18-16(15-26)14-24-22(25-18)19-5-3-4-9-23-19/h3-7,9,13-14H,8,10-12,15H2,1-2H3
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333050
PNG
(US10196391, Example 50)
Show SMILES COc1ccc(cc1)N1CCc2nc(ncc2C1)-c1ccccn1
Show InChI InChI=1S/C19H18N4O/c1-24-16-7-5-15(6-8-16)23-11-9-17-14(13-23)12-21-19(22-17)18-4-2-3-10-20-18/h2-8,10,12H,9,11,13H2,1H3
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333018
PNG
(2,3-difluoro-5-[2-(2-pyridyl)-7,8-dihydro-5H-pyrid...)
Show SMILES Oc1cc(cc(F)c1F)N1CCc2nc(ncc2C1)-c1ccccn1
Show InChI InChI=1S/C18H14F2N4O/c19-13-7-12(8-16(25)17(13)20)24-6-4-14-11(10-24)9-22-18(23-14)15-3-1-2-5-21-15/h1-3,5,7-9,25H,4,6,10H2
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333086
PNG
(US10196391, Example 86)
Show SMILES CCc1nc(nc2CCN(Cc12)c1ccc(cc1)S(C)(=O)=O)-c1ccccn1
Show InChI InChI=1S/C21H22N4O2S/c1-3-18-17-14-25(15-7-9-16(10-8-15)28(2,26)27)13-11-19(17)24-21(23-18)20-6-4-5-12-22-20/h4-10,12H,3,11,13-14H2,1-2H3
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.21E+4n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333088
PNG
(US10196391, Example 88)
Show SMILES CNc1nc(nc2CCN(Cc12)c1ccc(cc1)S(C)(=O)=O)-c1ccccn1
Show InChI InChI=1S/C20H21N5O2S/c1-21-19-16-13-25(14-6-8-15(9-7-14)28(2,26)27)12-10-17(16)23-20(24-19)18-5-3-4-11-22-18/h3-9,11H,10,12-13H2,1-2H3,(H,21,23,24)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.64E+4n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
Hepatitis GB virus B NS5B RNA-dependent RNA polymerase


(Hepatitis GB virus B)
BDBM333005
PNG
(US10196391, Example 5)
Show SMILES COc1ccc(nc1)-c1ncc2CN(CCc2n1)c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C20H20N4O3S/c1-27-16-5-8-19(21-12-16)20-22-11-14-13-24(10-9-18(14)23-20)15-3-6-17(7-4-15)28(2,25)26/h3-8,11-12H,9-10,13H2,1-2H3
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4.21E+4n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5104 cells/well. The cells were treated with a three-fold serial dilution ...


US Patent US10196391 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%