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Patent code US10196436

Compile Data Set for Download or QSAR
Found 116 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM333198
PNG
(US10196436, Compound 48)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(Nc4c(C)cccc4NC(=O)C=C)nc3N(C)C2=O)c1Cl
Show InChI InChI=1S/C25H24Cl2N6O4/c1-6-18(34)29-15-9-7-8-13(2)21(15)30-24-28-11-14-12-33(25(35)32(3)23(14)31-24)22-19(26)16(36-4)10-17(37-5)20(22)27/h6-11H,1,12H2,2-5H3,(H,29,34)(H,28,30,31)
PDB

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US Patent
n/an/a<10n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM333203
PNG
(US10196436, Compound 52)
Show SMILES CCN(CC)CCCCN(C(=O)C=C)c1ncc2cc(c(NC(=O)NC(C)(C)C)nc2n1)-c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C31H43N7O4/c1-9-26(39)38(15-13-12-14-37(10-2)11-3)29-32-20-22-18-25(21-16-23(41-7)19-24(17-21)42-8)28(33-27(22)34-29)35-30(40)36-31(4,5)6/h9,16-20H,1,10-15H2,2-8H3,(H2,32,33,34,35,36,40)
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n/an/a<10n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM333185
PNG
(US10196436, Compound 35)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2nc(Nc3c(Cl)cccc3NC(=O)C=C)ncc2c1
Show InChI InChI=1S/C25H19Cl3N4O3/c1-4-20(33)30-17-7-5-6-15(26)24(17)32-25-29-12-14-10-13(8-9-16(14)31-25)21-22(27)18(34-2)11-19(35-3)23(21)28/h4-12H,1H2,2-3H3,(H,30,33)(H,29,31,32)
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n/an/a<10n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM333160
PNG
(US10196436, Compound 12)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(nc2n(C)c1=O)N(C)C(=O)C=C
Show InChI InChI=1S/C20H18Cl2N4O4/c1-6-14(27)25(2)20-23-9-10-7-11(19(28)26(3)18(10)24-20)15-16(21)12(29-4)8-13(30-5)17(15)22/h6-9H,1H2,2-5H3
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n/an/a<10n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM333195
PNG
(US10196436, Compound 45)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1nc2cnc(Nc3c(C)cccc3NC(=O)C=C)nc2n(C)c1=O
Show InChI InChI=1S/C25H22Cl2N6O4/c1-6-17(34)29-13-9-7-8-12(2)21(13)31-25-28-11-14-23(32-25)33(3)24(35)22(30-14)18-19(26)15(36-4)10-16(37-5)20(18)27/h6-11H,1H2,2-5H3,(H,29,34)(H,28,31,32)
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n/an/a<10n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM333187
PNG
(US10196436, Compound 37)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2nc(Nc3c(F)c(F)ccc3NC(=O)C=C)ncc2c1
Show InChI InChI=1S/C25H18Cl2F2N4O3/c1-4-19(34)31-16-8-6-14(28)23(29)24(16)33-25-30-11-13-9-12(5-7-15(13)32-25)20-21(26)17(35-2)10-18(36-3)22(20)27/h4-11H,1H2,2-3H3,(H,31,34)(H,30,32,33)
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n/an/a<10n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM333189
PNG
(US10196436, Compound 39)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(Nc3c(C)cccc3NC(=O)C=C)cc2n(C)c1=O
Show InChI InChI=1S/C27H24Cl2N4O4/c1-6-22(34)31-17-9-7-8-14(2)26(17)32-21-11-18-15(13-30-21)10-16(27(35)33(18)3)23-24(28)19(36-4)12-20(37-5)25(23)29/h6-13H,1H2,2-5H3,(H,30,32)(H,31,34)
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n/an/a<10n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM333181
PNG
(US10196436, Compound 31)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(Nc3ccccc3NC(=O)C=C)cc2n(C)c1=O
Show InChI InChI=1S/C26H22Cl2N4O4/c1-5-22(33)31-17-9-7-6-8-16(17)30-21-11-18-14(13-29-21)10-15(26(34)32(18)2)23-24(27)19(35-3)12-20(36-4)25(23)28/h5-13H,1H2,2-4H3,(H,29,30)(H,31,33)
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n/an/a<10n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM333177
PNG
(US10196436, Compound 27 | US10196436, Compound 51)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2nc(Nc3c(F)cccc3NC(=O)C=C)ncc2c1
Show InChI InChI=1S/C25H19Cl2FN4O3/c1-4-20(33)30-17-7-5-6-15(28)24(17)32-25-29-12-14-10-13(8-9-16(14)31-25)21-22(26)18(34-2)11-19(35-3)23(21)27/h4-12H,1H2,2-3H3,(H,30,33)(H,29,31,32)
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n/an/a<10n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM333206
PNG
(US10196436, Compound 55)
Show SMILES CCN(CC)CCCCN(C(=O)C=C)c1ncc2cc(c(NC(=O)NC(C)(C)C)nc2n1)-c1c(Cl)c(OC)cc(OC)c1Cl
Show InChI InChI=1S/C31H41Cl2N7O4/c1-9-23(41)40(15-13-12-14-39(10-2)11-3)29-34-18-19-16-20(24-25(32)21(43-7)17-22(44-8)26(24)33)28(35-27(19)36-29)37-30(42)38-31(4,5)6/h9,16-18H,1,10-15H2,2-8H3,(H2,34,35,36,37,38,42)
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n/an/a<10n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM333204
PNG
(US10196436, Compound 53)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2nc(Nc3c(C)cc(cc3NC(=O)C=C)N3CCOCC3)ncc2c1
Show InChI InChI=1S/C30H29Cl2N5O4/c1-5-25(38)34-22-14-20(37-8-10-41-11-9-37)12-17(2)29(22)36-30-33-16-19-13-18(6-7-21(19)35-30)26-27(31)23(39-3)15-24(40-4)28(26)32/h5-7,12-16H,1,8-11H2,2-4H3,(H,34,38)(H,33,35,36)
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n/an/a<10n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM333192
PNG
(US10196436, Compound 42)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(Nc3c(C)cccc3NC(=O)C=C)nc2cc1OC
Show InChI InChI=1S/C27H24Cl2N4O4/c1-6-22(34)31-17-9-7-8-14(2)26(17)33-27-30-13-15-10-16(19(35-3)11-18(15)32-27)23-24(28)20(36-4)12-21(37-5)25(23)29/h6-13H,1H2,2-5H3,(H,31,34)(H,30,32,33)
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n/an/a<10n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM333176
PNG
(US10196436, Compound 26)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cnc2nc(Nc3c(C)cccc3NC(=O)C=C)ncc2c1
Show InChI InChI=1S/C25H21Cl2N5O3/c1-5-19(33)30-16-8-6-7-13(2)23(16)31-25-29-12-15-9-14(11-28-24(15)32-25)20-21(26)17(34-3)10-18(35-4)22(20)27/h5-12H,1H2,2-4H3,(H,30,33)(H,28,29,31,32)
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n/an/a<10n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM333155
PNG
(US10196436, Compound 7)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2nc(ncc2c1)N(C)C(=O)C=C
Show InChI InChI=1S/C20H17Cl2N3O3/c1-5-16(26)25(2)20-23-10-12-8-11(6-7-13(12)24-20)17-18(21)14(27-3)9-15(28-4)19(17)22/h5-10H,1H2,2-4H3
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n/an/a<10n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM333196
PNG
(US10196436, Compound 46)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(Nc3c(F)cccc3NC(=O)C=C)cc2n(C)c1=O
Show InChI InChI=1S/C26H21Cl2FN4O4/c1-5-21(34)31-16-8-6-7-15(29)25(16)32-20-10-17-13(12-30-20)9-14(26(35)33(17)2)22-23(27)18(36-3)11-19(37-4)24(22)28/h5-12H,1H2,2-4H3,(H,30,32)(H,31,34)
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n/an/a<10n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM333193
PNG
(US10196436, Compound 43)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(Nc3c(C)cccc3NC(=O)C=C)nc2n(C)c1=O
Show InChI InChI=1S/C26H23Cl2N5O4/c1-6-19(34)30-16-9-7-8-13(2)23(16)31-26-29-12-14-10-15(25(35)33(3)24(14)32-26)20-21(27)17(36-4)11-18(37-5)22(20)28/h6-12H,1H2,2-5H3,(H,30,34)(H,29,31,32)
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n/an/a<10n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM333184
PNG
(US10196436, Compound 34)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc(F)c2nc(Nc3c(C)cccc3NC(=O)C=C)ncc2c1
Show InChI InChI=1S/C26H21Cl2FN4O3/c1-5-20(34)31-17-8-6-7-13(2)24(17)32-26-30-12-15-9-14(10-16(29)25(15)33-26)21-22(27)18(35-3)11-19(36-4)23(21)28/h5-12H,1H2,2-4H3,(H,31,34)(H,30,32,33)
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n/an/a<10n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM333182
PNG
(US10196436, Compound 32)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2nc(Nc3c(C)cc(F)cc3NC(=O)C=C)ncc2c1
Show InChI InChI=1S/C26H21Cl2FN4O3/c1-5-21(34)31-18-10-16(29)8-13(2)25(18)33-26-30-12-15-9-14(6-7-17(15)32-26)22-23(27)19(35-3)11-20(36-4)24(22)28/h5-12H,1H2,2-4H3,(H,31,34)(H,30,32,33)
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n/an/a<10n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM50233461
PNG
(CHEMBL4068896)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2nc(Nc3c(C)cccc3NC(=O)C=C)ncc2c1
Show InChI InChI=1S/C26H22Cl2N4O3/c1-5-21(33)30-18-8-6-7-14(2)25(18)32-26-29-13-16-11-15(9-10-17(16)31-26)22-23(27)19(34-3)12-20(35-4)24(22)28/h5-13H,1H2,2-4H3,(H,30,33)(H,29,31,32)
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US Patent
n/an/a<10n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM333197
PNG
(US10196436, Compound 47)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc(OC)c2nc(Nc3c(F)cccc3NC(=O)C=C)ncc2c1
Show InChI InChI=1S/C26H21Cl2FN4O4/c1-5-20(34)31-16-8-6-7-15(29)25(16)33-26-30-12-14-9-13(10-19(37-4)24(14)32-26)21-22(27)17(35-2)11-18(36-3)23(21)28/h5-12H,1H2,2-4H3,(H,31,34)(H,30,32,33)
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n/an/a<10n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM333191
PNG
(US10196436, Compound 41)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc(OC)c2nc(Nc3c(C)cccc3NC(=O)C=C)ncc2c1
Show InChI InChI=1S/C27H24Cl2N4O4/c1-6-21(34)31-17-9-7-8-14(2)25(17)32-27-30-13-16-10-15(11-20(37-5)26(16)33-27)22-23(28)18(35-3)12-19(36-4)24(22)29/h6-13H,1H2,2-5H3,(H,31,34)(H,30,32,33)
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US Patent
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM333180
PNG
(US10196436, Compound 30)
Show SMILES COc1cccc(NC(=O)C=C)c1Nc1ncc2cc(ccc2n1)-c1c(Cl)c(OC)cc(OC)c1Cl
Show InChI InChI=1S/C26H22Cl2N4O4/c1-5-21(33)30-17-7-6-8-18(34-2)25(17)32-26-29-13-15-11-14(9-10-16(15)31-26)22-23(27)19(35-3)12-20(36-4)24(22)28/h5-13H,1H2,2-4H3,(H,30,33)(H,29,31,32)
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n/an/a<10n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM333156
PNG
(US10196436, Compound 8)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cnc2nc(ncc2c1)N(C)C(=O)C=C
Show InChI InChI=1S/C19H16Cl2N4O3/c1-5-14(26)25(2)19-23-9-11-6-10(8-22-18(11)24-19)15-16(20)12(27-3)7-13(28-4)17(15)21/h5-9H,1H2,2-4H3
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US Patent
n/an/a<10n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM333161
PNG
(US10196436, Compound 13)
Show SMILES Cc1cccc(NC(=O)C=C)c1Nc1ncc2cc(ccc2n1)-c1c(Cl)cccc1Cl
Show InChI InChI=1S/C24H18Cl2N4O/c1-3-21(31)28-20-9-4-6-14(2)23(20)30-24-27-13-16-12-15(10-11-19(16)29-24)22-17(25)7-5-8-18(22)26/h3-13H,1H2,2H3,(H,28,31)(H,27,29,30)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM333166
PNG
(US10196436, Compound 17A)
Show SMILES COc1ccc(Cl)c(c1F)-c1ccc2nc(Nc3c(C)cccc3NC(=O)C=C)ncc2c1
Show InChI InChI=1S/C25H20ClFN4O2/c1-4-21(32)29-19-7-5-6-14(2)24(19)31-25-28-13-16-12-15(8-10-18(16)30-25)22-17(26)9-11-20(33-3)23(22)27/h4-13H,1H2,2-3H3,(H,29,32)(H,28,30,31)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM333171
PNG
(US10196436, Compound 22)
Show SMILES Cc1cccc(NC(=O)C=C)c1Nc1ncc2cc(-c3c(Cl)cccc3Cl)c(=O)n(C)c2n1
Show InChI InChI=1S/C24H19Cl2N5O2/c1-4-19(32)28-18-10-5-7-13(2)21(18)29-24-27-12-14-11-15(23(33)31(3)22(14)30-24)20-16(25)8-6-9-17(20)26/h4-12H,1H2,2-3H3,(H,28,32)(H,27,29,30)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM333199
PNG
(US10196436, Compound 49)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2nc(Nc3c(C)cc(Cl)cc3NC(=O)C=C)ncc2c1
Show InChI InChI=1S/C26H21Cl3N4O3/c1-5-21(34)31-18-10-16(27)8-13(2)25(18)33-26-30-12-15-9-14(6-7-17(15)32-26)22-23(28)19(35-3)11-20(36-4)24(22)29/h5-12H,1H2,2-4H3,(H,31,34)(H,30,32,33)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM333197
PNG
(US10196436, Compound 47)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc(OC)c2nc(Nc3c(F)cccc3NC(=O)C=C)ncc2c1
Show InChI InChI=1S/C26H21Cl2FN4O4/c1-5-20(34)31-16-8-6-7-15(29)25(16)33-26-30-12-14-9-13(10-19(37-4)24(14)32-26)21-22(27)17(35-2)11-18(36-3)23(21)28/h5-12H,1H2,2-4H3,(H,31,34)(H,30,32,33)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.1 ng/ul of wild type FGFR-1 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM333160
PNG
(US10196436, Compound 12)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(nc2n(C)c1=O)N(C)C(=O)C=C
Show InChI InChI=1S/C20H18Cl2N4O4/c1-6-14(27)25(2)20-23-9-10-7-11(19(28)26(3)18(10)24-20)15-16(21)12(29-4)8-13(30-5)17(15)22/h6-9H,1H2,2-5H3
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.1 ng/ul of wild type FGFR-1 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM333192
PNG
(US10196436, Compound 42)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(Nc3c(C)cccc3NC(=O)C=C)nc2cc1OC
Show InChI InChI=1S/C27H24Cl2N4O4/c1-6-22(34)31-17-9-7-8-14(2)26(17)33-27-30-13-15-10-16(19(35-3)11-18(15)32-27)23-24(28)20(36-4)12-21(37-5)25(23)29/h6-13H,1H2,2-5H3,(H,31,34)(H,30,32,33)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.1 ng/ul of wild type FGFR-1 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM333151
PNG
(US10196436, Compound 3)
Show SMILES COc1cc(OC)cc(c1)N1CN(C)c2nc(SC)ncc2C1
Show InChI InChI=1S/C16H20N4O2S/c1-19-10-20(9-11-8-17-16(23-4)18-15(11)19)12-5-13(21-2)7-14(6-12)22-3/h5-8H,9-10H2,1-4H3
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM333205
PNG
(US10196436, Compound 54)
Show SMILES CN1CCC(CC1)NC(=O)c1ccc(Nc2ncc(C)c(n2)N2CCN(CC2)C(=O)Nc2ccc(cc2)C#N)c(NC(=O)C=C)c1
Show InChI InChI=1S/C33H38N10O3/c1-4-29(44)38-28-19-24(31(45)36-26-11-13-41(3)14-12-26)7-10-27(28)39-32-35-21-22(2)30(40-32)42-15-17-43(18-16-42)33(46)37-25-8-5-23(20-34)6-9-25/h4-10,19,21,26H,1,11-18H2,2-3H3,(H,36,45)(H,37,46)(H,38,44)(H,35,39,40)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM333177
PNG
(US10196436, Compound 27 | US10196436, Compound 51)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2nc(Nc3c(F)cccc3NC(=O)C=C)ncc2c1
Show InChI InChI=1S/C25H19Cl2FN4O3/c1-4-20(33)30-17-7-5-6-15(28)24(17)32-25-29-12-14-10-13(8-9-16(14)31-25)21-22(26)18(34-2)11-19(35-3)23(21)27/h4-12H,1H2,2-3H3,(H,30,33)(H,29,31,32)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM333203
PNG
(US10196436, Compound 52)
Show SMILES CCN(CC)CCCCN(C(=O)C=C)c1ncc2cc(c(NC(=O)NC(C)(C)C)nc2n1)-c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C31H43N7O4/c1-9-26(39)38(15-13-12-14-37(10-2)11-3)29-32-20-22-18-25(21-16-23(41-7)19-24(17-21)42-8)28(33-27(22)34-29)35-30(40)36-31(4,5)6/h9,16-20H,1,10-15H2,2-8H3,(H2,32,33,34,35,36,40)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.1 ng/ul of wild type FGFR-1 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM333200
PNG
(US10196436, Compound 49A)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2nc(Nc3c(C)cccc3NS(=O)(=O)C=C)ncc2c1
Show InChI InChI=1S/C25H22Cl2N4O4S/c1-5-36(32,33)31-18-8-6-7-14(2)24(18)30-25-28-13-16-11-15(9-10-17(16)29-25)21-22(26)19(34-3)12-20(35-4)23(21)27/h5-13,31H,1H2,2-4H3,(H,28,29,30)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM333183
PNG
(US10196436, Compound 33)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2nc(Nc3c(C)c(F)ccc3NC(=O)C=C)ncc2c1
Show InChI InChI=1S/C26H21Cl2FN4O3/c1-5-21(34)31-18-9-7-16(29)13(2)25(18)33-26-30-12-15-10-14(6-8-17(15)32-26)22-23(27)19(35-3)11-20(36-4)24(22)28/h5-12H,1H2,2-4H3,(H,31,34)(H,30,32,33)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM333181
PNG
(US10196436, Compound 31)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(Nc3ccccc3NC(=O)C=C)cc2n(C)c1=O
Show InChI InChI=1S/C26H22Cl2N4O4/c1-5-22(33)31-17-9-7-6-8-16(17)30-21-11-18-14(13-29-21)10-15(26(34)32(18)2)23-24(27)19(35-3)12-20(36-4)25(23)28/h5-13H,1H2,2-4H3,(H,29,30)(H,31,33)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.1 ng/ul of wild type FGFR-1 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM333178
PNG
(US10196436, Compound 28)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2nc(Nc3c(C)cc(C)cc3NC(=O)C=C)ncc2c1
Show InChI InChI=1S/C27H24Cl2N4O3/c1-6-22(34)31-19-10-14(2)9-15(3)26(19)33-27-30-13-17-11-16(7-8-18(17)32-27)23-24(28)20(35-4)12-21(36-5)25(23)29/h6-13H,1H2,2-5H3,(H,31,34)(H,30,32,33)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM333167
PNG
(US10196436, Compound 18)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(Nc3c(C)cccc3NC(=O)C=C)cc2n(C)c1=O
Show InChI InChI=1S/C27H26N4O4/c1-6-25(32)29-22-9-7-8-16(2)26(22)30-24-14-23-18(15-28-24)12-21(27(33)31(23)3)17-10-19(34-4)13-20(11-17)35-5/h6-15H,1H2,2-5H3,(H,28,30)(H,29,32)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM333169
PNG
(US10196436, Compound 20)
Show SMILES CC(C)Oc1cc(NC(=O)NCC(F)(F)F)cc(c1)-c1cnc2c(CNC(=O)C#C)cccn12
Show InChI InChI=1S/C23H22F3N5O3/c1-4-20(32)27-11-15-6-5-7-31-19(12-28-21(15)31)16-8-17(10-18(9-16)34-14(2)3)30-22(33)29-13-23(24,25)26/h1,5-10,12,14H,11,13H2,2-3H3,(H,27,32)(H2,29,30,33)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM333162
PNG
(US10196436, Compound 14)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(nc3N(C)C2=O)N(C)C(=O)C=C)c1Cl
Show InChI InChI=1S/C19H19Cl2N5O4/c1-6-13(27)24(2)18-22-8-10-9-26(19(28)25(3)17(10)23-18)16-14(20)11(29-4)7-12(30-5)15(16)21/h6-8H,1,9H2,2-5H3
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n/an/a 55n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM333206
PNG
(US10196436, Compound 55)
Show SMILES CCN(CC)CCCCN(C(=O)C=C)c1ncc2cc(c(NC(=O)NC(C)(C)C)nc2n1)-c1c(Cl)c(OC)cc(OC)c1Cl
Show InChI InChI=1S/C31H41Cl2N7O4/c1-9-23(41)40(15-13-12-14-39(10-2)11-3)29-34-18-19-16-20(24-25(32)21(43-7)17-22(44-8)26(24)33)28(35-27(19)36-29)37-30(42)38-31(4,5)6/h9,16-18H,1,10-15H2,2-8H3,(H2,34,35,36,37,38,42)
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n/an/a 55n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.1 ng/ul of wild type FGFR-1 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM333177
PNG
(US10196436, Compound 27 | US10196436, Compound 51)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2nc(Nc3c(F)cccc3NC(=O)C=C)ncc2c1
Show InChI InChI=1S/C25H19Cl2FN4O3/c1-4-20(33)30-17-7-5-6-15(28)24(17)32-25-29-12-14-10-13(8-9-16(14)31-25)21-22(26)18(34-2)11-19(35-3)23(21)27/h4-12H,1H2,2-3H3,(H,30,33)(H,29,31,32)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.1 ng/ul of wild type FGFR-1 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM333168
PNG
(US10196436, Compound 19)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(Nc3c(C)cccc3NC(=O)C=C)nc2n(C)c1=O
Show InChI InChI=1S/C26H25N5O4/c1-6-22(32)28-21-9-7-8-15(2)23(21)29-26-27-14-17-12-20(25(33)31(3)24(17)30-26)16-10-18(34-4)13-19(11-16)35-5/h6-14H,1H2,2-5H3,(H,28,32)(H,27,29,30)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM333173
PNG
(US10196436, Compound 24)
Show SMILES COc1cc(OC)c(Cl)c(C#Cc2cnc(Nc3c(C)cccc3NC(=O)C=C)nc2)c1Cl
Show InChI InChI=1S/C24H20Cl2N4O3/c1-5-20(31)29-17-8-6-7-14(2)23(17)30-24-27-12-15(13-28-24)9-10-16-21(25)18(32-3)11-19(33-4)22(16)26/h5-8,11-13H,1H2,2-4H3,(H,29,31)(H,27,28,30)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM333165
PNG
(US10196436, Compound 17)
Show SMILES Cc1ccc(cc1-c1ccc2nc(Nc3c(Cl)cccc3NC(=O)C=C)ncc2c1)C(N)=O
Show InChI InChI=1S/C25H20ClN5O2/c1-3-22(32)29-21-6-4-5-19(26)23(21)31-25-28-13-17-11-15(9-10-20(17)30-25)18-12-16(24(27)33)8-7-14(18)2/h3-13H,1H2,2H3,(H2,27,33)(H,29,32)(H,28,30,31)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM333153
PNG
(US10196436, Compound 5)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc(nc2N(C)C1=O)N(C)C(=O)C=C
Show InChI InChI=1S/C19H21N5O4/c1-6-16(25)22(2)18-20-10-12-11-24(19(26)23(3)17(12)21-18)13-7-14(27-4)9-15(8-13)28-5/h6-10H,1,11H2,2-5H3
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM333163
PNG
(US10196436, Compound 15)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(Nc3ccccc3NC(=O)C=C)cc2n(C)c1=O
Show InChI InChI=1S/C26H24N4O4/c1-5-25(31)29-22-9-7-6-8-21(22)28-24-14-23-17(15-27-24)12-20(26(32)30(23)2)16-10-18(33-3)13-19(11-16)34-4/h5-15H,1H2,2-4H3,(H,27,28)(H,29,31)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM333149
PNG
(US10196436, Compound 1)
Show SMILES COc1cc(OC)cc(c1)-c1ccc2nc(ncc2c1)N(C)C(=O)C=C
Show InChI InChI=1S/C20H19N3O3/c1-5-19(24)23(2)20-21-12-15-8-13(6-7-18(15)22-20)14-9-16(25-3)11-17(10-14)26-4/h5-12H,1H2,2-4H3
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM50233461
PNG
(CHEMBL4068896)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2nc(Nc3c(C)cccc3NC(=O)C=C)ncc2c1
Show InChI InChI=1S/C26H22Cl2N4O3/c1-5-21(33)30-18-8-6-7-14(2)25(18)32-26-29-13-16-11-15(9-10-17(16)31-26)22-23(27)19(34-3)12-20(35-4)24(22)28/h5-13H,1H2,2-4H3,(H,30,33)(H,29,31,32)
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n/an/a 550n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.1 ng/ul of wild type FGFR-1 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM333152
PNG
(US10196436, Compound 4)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc(SC)nc2N(C)C1=O
Show InChI InChI=1S/C16H18N4O3S/c1-19-14-10(8-17-15(18-14)24-4)9-20(16(19)21)11-5-12(22-2)7-13(6-11)23-3/h5-8H,9H2,1-4H3
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM333175
PNG
(US10196436, Compound 25A)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2nc(Oc3c(C)cccc3NC(=O)C=C)ncc2c1
Show InChI InChI=1S/C26H21Cl2N3O4/c1-5-21(32)30-18-8-6-7-14(2)25(18)35-26-29-13-16-11-15(9-10-17(16)31-26)22-23(27)19(33-3)12-20(34-4)24(22)28/h5-13H,1H2,2-4H3,(H,30,32)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM333176
PNG
(US10196436, Compound 26)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cnc2nc(Nc3c(C)cccc3NC(=O)C=C)ncc2c1
Show InChI InChI=1S/C25H21Cl2N5O3/c1-5-19(33)30-16-8-6-7-13(2)23(16)31-25-29-12-15-9-14(11-28-24(15)32-25)20-21(26)17(34-3)10-18(35-4)22(20)27/h5-12H,1H2,2-4H3,(H,30,33)(H,28,29,31,32)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.1 ng/ul of wild type FGFR-1 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM333179
PNG
(US10196436, Compound 29)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2nc(Nc3c(C)cccc3NC(=O)C(C)=C)ncc2c1
Show InChI InChI=1S/C27H24Cl2N4O3/c1-14(2)26(34)31-19-8-6-7-15(3)25(19)33-27-30-13-17-11-16(9-10-18(17)32-27)22-23(28)20(35-4)12-21(36-5)24(22)29/h6-13H,1H2,2-5H3,(H,31,34)(H,30,32,33)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM333194
PNG
(US10196436, Compound 44)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(Nc3ccccc3NC(=O)C=C)cc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C30H32N6O4/c1-7-27(37)33-24-11-9-8-10-23(24)32-26-16-25-19(17-31-26)14-22(18-12-20(39-5)15-21(13-18)40-6)28(34-25)35-29(38)36-30(2,3)4/h7-17H,1H2,2-6H3,(H,31,32)(H,33,37)(H2,34,35,36,38)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM333198
PNG
(US10196436, Compound 48)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(Nc4c(C)cccc4NC(=O)C=C)nc3N(C)C2=O)c1Cl
Show InChI InChI=1S/C25H24Cl2N6O4/c1-6-18(34)29-15-9-7-8-13(2)21(15)30-24-28-11-14-12-33(25(35)32(3)23(14)31-24)22-19(26)16(36-4)10-17(37-5)20(22)27/h6-11H,1,12H2,2-5H3,(H,29,34)(H,28,30,31)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.1 ng/ul of wild type FGFR-1 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM333159
PNG
(US10196436, Compound 11)
Show SMILES CCCS(=O)(=O)NC1CCCN(C1)c1ccnc(Nc2ccccc2NC(=O)C=C)n1
Show InChI InChI=1S/C21H28N6O3S/c1-3-14-31(29,30)26-16-8-7-13-27(15-16)19-11-12-22-21(25-19)24-18-10-6-5-9-17(18)23-20(28)4-2/h4-6,9-12,16,26H,2-3,7-8,13-15H2,1H3,(H,23,28)(H,22,24,25)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM333184
PNG
(US10196436, Compound 34)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc(F)c2nc(Nc3c(C)cccc3NC(=O)C=C)ncc2c1
Show InChI InChI=1S/C26H21Cl2FN4O3/c1-5-20(34)31-17-8-6-7-13(2)24(17)32-26-30-12-15-9-14(10-16(29)25(15)33-26)21-22(27)18(35-3)11-19(36-4)23(21)28/h5-12H,1H2,2-4H3,(H,31,34)(H,30,32,33)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.1 ng/ul of wild type FGFR-1 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM333185
PNG
(US10196436, Compound 35)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2nc(Nc3c(Cl)cccc3NC(=O)C=C)ncc2c1
Show InChI InChI=1S/C25H19Cl3N4O3/c1-4-20(33)30-17-7-5-6-15(26)24(17)32-25-29-12-14-10-13(8-9-16(14)31-25)21-22(27)18(34-2)11-19(35-3)23(21)28/h4-12H,1H2,2-3H3,(H,30,33)(H,29,31,32)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.1 ng/ul of wild type FGFR-1 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM333204
PNG
(US10196436, Compound 53)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2nc(Nc3c(C)cc(cc3NC(=O)C=C)N3CCOCC3)ncc2c1
Show InChI InChI=1S/C30H29Cl2N5O4/c1-5-25(38)34-22-14-20(37-8-10-41-11-9-37)12-17(2)29(22)36-30-33-16-19-13-18(6-7-21(19)35-30)26-27(31)23(39-3)15-24(40-4)28(26)32/h5-7,12-16H,1,8-11H2,2-4H3,(H,34,38)(H,33,35,36)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.1 ng/ul of wild type FGFR-1 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM333162
PNG
(US10196436, Compound 14)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(nc3N(C)C2=O)N(C)C(=O)C=C)c1Cl
Show InChI InChI=1S/C19H19Cl2N5O4/c1-6-13(27)24(2)18-22-8-10-9-26(19(28)25(3)17(10)23-18)16-14(20)11(29-4)7-12(30-5)15(16)21/h6-8H,1,9H2,2-5H3
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n/an/a 550n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.1 ng/ul of wild type FGFR-1 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM333180
PNG
(US10196436, Compound 30)
Show SMILES COc1cccc(NC(=O)C=C)c1Nc1ncc2cc(ccc2n1)-c1c(Cl)c(OC)cc(OC)c1Cl
Show InChI InChI=1S/C26H22Cl2N4O4/c1-5-21(33)30-17-7-6-8-18(34-2)25(17)32-26-29-13-15-11-14(9-10-16(15)31-26)22-23(27)19(35-3)12-20(36-4)24(22)28/h5-13H,1H2,2-4H3,(H,30,33)(H,29,31,32)
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n/an/a 550n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.1 ng/ul of wild type FGFR-1 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM333191
PNG
(US10196436, Compound 41)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc(OC)c2nc(Nc3c(C)cccc3NC(=O)C=C)ncc2c1
Show InChI InChI=1S/C27H24Cl2N4O4/c1-6-21(34)31-17-9-7-8-14(2)25(17)32-27-30-13-16-10-15(11-20(37-5)26(16)33-27)22-23(28)18(35-3)12-19(36-4)24(22)29/h6-13H,1H2,2-5H3,(H,31,34)(H,30,32,33)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.1 ng/ul of wild type FGFR-1 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM333156
PNG
(US10196436, Compound 8)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cnc2nc(ncc2c1)N(C)C(=O)C=C
Show InChI InChI=1S/C19H16Cl2N4O3/c1-5-14(26)25(2)19-23-9-11-6-10(8-22-18(11)24-19)15-16(20)12(27-3)7-13(28-4)17(15)21/h5-9H,1H2,2-4H3
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.1 ng/ul of wild type FGFR-1 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM333170
PNG
(US10196436, Compound 21)
Show SMILES FC(F)(F)CNC(=O)Nc1cccc(c1)-c1cnc2cc(ccn12)-c1ccccc1NC(=O)C=C
Show InChI InChI=1S/C25H20F3N5O2/c1-2-23(34)32-20-9-4-3-8-19(20)16-10-11-33-21(14-29-22(33)13-16)17-6-5-7-18(12-17)31-24(35)30-15-25(26,27)28/h2-14H,1,15H2,(H,32,34)(H2,30,31,35)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM333179
PNG
(US10196436, Compound 29)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2nc(Nc3c(C)cccc3NC(=O)C(C)=C)ncc2c1
Show InChI InChI=1S/C27H24Cl2N4O3/c1-14(2)26(34)31-19-8-6-7-15(3)25(19)33-27-30-13-17-11-16(9-10-18(17)32-27)22-23(28)20(35-4)12-21(36-5)24(22)29/h6-13H,1H2,2-5H3,(H,31,34)(H,30,32,33)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.1 ng/ul of wild type FGFR-1 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM333186
PNG
(US10196436, Compound 36)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2nc(Nc3c(F)cc(F)cc3NC(=O)C=C)ncc2c1
Show InChI InChI=1S/C25H18Cl2F2N4O3/c1-4-20(34)31-17-9-14(28)8-15(29)24(17)33-25-30-11-13-7-12(5-6-16(13)32-25)21-22(26)18(35-2)10-19(36-3)23(21)27/h4-11H,1H2,2-3H3,(H,31,34)(H,30,32,33)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM333188
PNG
(Synthesis of N-(2-(3-(3-isopropoxy-5-(3-(2,2,2-tri...)
Show SMILES CC(C)Oc1cc(NC(=O)NCC(F)(F)F)cc(c1)-c1cnc2cc(ccn12)-c1ccccc1NC(=O)C=C
Show InChI InChI=1S/C28H26F3N5O3/c1-4-26(37)35-23-8-6-5-7-22(23)18-9-10-36-24(15-32-25(36)13-18)19-11-20(14-21(12-19)39-17(2)3)34-27(38)33-16-28(29,30)31/h4-15,17H,1,16H2,2-3H3,(H,35,37)(H2,33,34,38)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM333193
PNG
(US10196436, Compound 43)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(Nc3c(C)cccc3NC(=O)C=C)nc2n(C)c1=O
Show InChI InChI=1S/C26H23Cl2N5O4/c1-6-19(34)30-16-9-7-8-13(2)23(16)31-26-29-12-14-10-15(25(35)33(3)24(14)32-26)20-21(27)17(36-4)11-18(37-5)22(20)28/h6-12H,1H2,2-5H3,(H,30,34)(H,29,31,32)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.1 ng/ul of wild type FGFR-1 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM333196
PNG
(US10196436, Compound 46)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(Nc3c(F)cccc3NC(=O)C=C)cc2n(C)c1=O
Show InChI InChI=1S/C26H21Cl2FN4O4/c1-5-21(34)31-16-8-6-7-15(29)25(16)32-20-10-17-13(12-30-20)9-14(26(35)33(17)2)22-23(27)18(36-3)11-19(37-4)24(22)28/h5-12H,1H2,2-4H3,(H,30,32)(H,31,34)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.1 ng/ul of wild type FGFR-1 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM333164
PNG
(US10196436, Compound 16)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(Nc3ccccc3NC(=O)C=C)nc2n(C)c1=O
Show InChI InChI=1S/C25H23N5O4/c1-5-22(31)27-20-8-6-7-9-21(20)28-25-26-14-16-12-19(24(32)30(2)23(16)29-25)15-10-17(33-3)13-18(11-15)34-4/h5-14H,1H2,2-4H3,(H,27,31)(H,26,28,29)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM333187
PNG
(US10196436, Compound 37)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2nc(Nc3c(F)c(F)ccc3NC(=O)C=C)ncc2c1
Show InChI InChI=1S/C25H18Cl2F2N4O3/c1-4-19(34)31-16-8-6-14(28)23(29)24(16)33-25-30-11-13-9-12(5-7-15(13)32-25)20-21(26)17(35-2)10-18(36-3)22(20)27/h4-11H,1H2,2-3H3,(H,31,34)(H,30,32,33)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.1 ng/ul of wild type FGFR-1 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM333200
PNG
(US10196436, Compound 49A)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2nc(Nc3c(C)cccc3NS(=O)(=O)C=C)ncc2c1
Show InChI InChI=1S/C25H22Cl2N4O4S/c1-5-36(32,33)31-18-8-6-7-14(2)24(18)30-25-28-13-16-11-15(9-10-17(16)29-25)21-22(26)19(34-3)12-20(35-4)23(21)27/h5-13,31H,1H2,2-4H3,(H,28,29,30)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.1 ng/ul of wild type FGFR-1 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM333201
PNG
(US10196436, Compound 50)
Show SMILES FC(F)(F)c1cccc(NC(=O)N2CCN(CC2)c2nc(Nc3ccccc3NC(=O)C=C)ncc2Cl)c1
Show InChI InChI=1S/C25H23ClF3N7O2/c1-2-21(37)32-19-8-3-4-9-20(19)33-23-30-15-18(26)22(34-23)35-10-12-36(13-11-35)24(38)31-17-7-5-6-16(14-17)25(27,28)29/h2-9,14-15H,1,10-13H2,(H,31,38)(H,32,37)(H,30,33,34)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM333150
PNG
(US10196436, Compound 2)
Show SMILES CN(C(=O)C=C)c1ncc2cc(ccc2n1)-c1c(Cl)cccc1Cl
Show InChI InChI=1S/C18H13Cl2N3O/c1-3-16(24)23(2)18-21-10-12-9-11(7-8-15(12)22-18)17-13(19)5-4-6-14(17)20/h3-10H,1H2,2H3
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM333154
PNG
(US10196436, Compound 6)
Show SMILES COc1cc(OC)cc(c1)C#Cc1cnc(Nc2c(C)cccc2NC(=O)C=C)nc1
Show InChI InChI=1S/C24H22N4O3/c1-5-22(29)27-21-8-6-7-16(2)23(21)28-24-25-14-18(15-26-24)10-9-17-11-19(30-3)13-20(12-17)31-4/h5-8,11-15H,1H2,2-4H3,(H,27,29)(H,25,26,28)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM333157
PNG
(US10196436, Compound 9)
Show SMILES Cc1cccc(NC(=O)C=C)c1Nc1ncc2cc(ccc2n1)-c1cc(ccc1F)C(N)=O
Show InChI InChI=1S/C25H20FN5O2/c1-3-22(32)29-21-6-4-5-14(2)23(21)31-25-28-13-17-11-15(8-10-20(17)30-25)18-12-16(24(27)33)7-9-19(18)26/h3-13H,1H2,2H3,(H2,27,33)(H,29,32)(H,28,30,31)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM333172
PNG
(US10196436, Compound 23)
Show SMILES Cc1cnc(Nc2ccccc2NC(=O)C=C)nc1N1CCN(CC1)C(=O)Nc1ccc(cc1)C#N
Show InChI InChI=1S/C26H26N8O2/c1-3-23(35)30-21-6-4-5-7-22(21)31-25-28-17-18(2)24(32-25)33-12-14-34(15-13-33)26(36)29-20-10-8-19(16-27)9-11-20/h3-11,17H,1,12-15H2,2H3,(H,29,36)(H,30,35)(H,28,31,32)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM333190
PNG
(US10196436, Compound 40)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(Nc3ccccc3NC(=O)C=C)c(C)c2n(C)c1=O
Show InChI InChI=1S/C27H24Cl2N4O4/c1-6-21(34)31-17-9-7-8-10-18(17)32-26-14(2)25-15(13-30-26)11-16(27(35)33(25)3)22-23(28)19(36-4)12-20(37-5)24(22)29/h6-13H,1H2,2-5H3,(H,30,32)(H,31,34)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM333159
PNG
(US10196436, Compound 11)
Show SMILES CCCS(=O)(=O)NC1CCCN(C1)c1ccnc(Nc2ccccc2NC(=O)C=C)n1
Show InChI InChI=1S/C21H28N6O3S/c1-3-14-31(29,30)26-16-8-7-13-27(15-16)19-11-12-22-21(25-19)24-18-10-6-5-9-17(18)23-20(28)4-2/h4-6,9-12,16,26H,2-3,7-8,13-15H2,1H3,(H,23,28)(H,22,24,25)
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n/an/a>1.00E+3n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.1 ng/ul of wild type FGFR-1 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM333201
PNG
(US10196436, Compound 50)
Show SMILES FC(F)(F)c1cccc(NC(=O)N2CCN(CC2)c2nc(Nc3ccccc3NC(=O)C=C)ncc2Cl)c1
Show InChI InChI=1S/C25H23ClF3N7O2/c1-2-21(37)32-19-8-3-4-9-20(19)33-23-30-15-18(26)22(34-23)35-10-12-36(13-11-35)24(38)31-17-7-5-6-16(14-17)25(27,28)29/h2-9,14-15H,1,10-13H2,(H,31,38)(H,32,37)(H,30,33,34)
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n/an/a>1.00E+3n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.1 ng/ul of wild type FGFR-1 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM333172
PNG
(US10196436, Compound 23)
Show SMILES Cc1cnc(Nc2ccccc2NC(=O)C=C)nc1N1CCN(CC1)C(=O)Nc1ccc(cc1)C#N
Show InChI InChI=1S/C26H26N8O2/c1-3-23(35)30-21-6-4-5-7-22(21)31-25-28-17-18(2)24(32-25)33-12-14-34(15-13-33)26(36)29-20-10-8-19(16-27)9-11-20/h3-11,17H,1,12-15H2,2H3,(H,29,36)(H,30,35)(H,28,31,32)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.1 ng/ul of wild type FGFR-1 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM333199
PNG
(US10196436, Compound 49)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2nc(Nc3c(C)cc(Cl)cc3NC(=O)C=C)ncc2c1
Show InChI InChI=1S/C26H21Cl3N4O3/c1-5-21(34)31-18-10-16(27)8-13(2)25(18)33-26-30-12-15-9-14(6-7-17(15)32-26)22-23(28)19(35-3)11-20(36-4)24(22)29/h5-12H,1H2,2-4H3,(H,31,34)(H,30,32,33)
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n/an/a>1.00E+3n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.1 ng/ul of wild type FGFR-1 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM333149
PNG
(US10196436, Compound 1)
Show SMILES COc1cc(OC)cc(c1)-c1ccc2nc(ncc2c1)N(C)C(=O)C=C
Show InChI InChI=1S/C20H19N3O3/c1-5-19(24)23(2)20-21-12-15-8-13(6-7-18(15)22-20)14-9-16(25-3)11-17(10-14)26-4/h5-12H,1H2,2-4H3
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.1 ng/ul of wild type FGFR-1 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM333165
PNG
(US10196436, Compound 17)
Show SMILES Cc1ccc(cc1-c1ccc2nc(Nc3c(Cl)cccc3NC(=O)C=C)ncc2c1)C(N)=O
Show InChI InChI=1S/C25H20ClN5O2/c1-3-22(32)29-21-6-4-5-19(26)23(21)31-25-28-13-17-11-15(9-10-20(17)30-25)18-12-16(24(27)33)8-7-14(18)2/h3-13H,1H2,2H3,(H2,27,33)(H,29,32)(H,28,30,31)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.1 ng/ul of wild type FGFR-1 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM333175
PNG
(US10196436, Compound 25A)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2nc(Oc3c(C)cccc3NC(=O)C=C)ncc2c1
Show InChI InChI=1S/C26H21Cl2N3O4/c1-5-21(32)30-18-8-6-7-14(2)25(18)35-26-29-13-16-11-15(9-10-17(16)31-26)22-23(27)19(33-3)12-20(34-4)24(22)28/h5-13H,1H2,2-4H3,(H,30,32)
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n/an/a>1.00E+3n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.1 ng/ul of wild type FGFR-1 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM333189
PNG
(US10196436, Compound 39)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(Nc3c(C)cccc3NC(=O)C=C)cc2n(C)c1=O
Show InChI InChI=1S/C27H24Cl2N4O4/c1-6-22(34)31-17-9-7-8-14(2)26(17)32-21-11-18-15(13-30-21)10-16(27(35)33(18)3)23-24(28)19(36-4)12-20(37-5)25(23)29/h6-13H,1H2,2-5H3,(H,30,32)(H,31,34)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.1 ng/ul of wild type FGFR-1 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM333195
PNG
(US10196436, Compound 45)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1nc2cnc(Nc3c(C)cccc3NC(=O)C=C)nc2n(C)c1=O
Show InChI InChI=1S/C25H22Cl2N6O4/c1-6-17(34)29-13-9-7-8-12(2)21(13)31-25-28-11-14-23(32-25)33(3)24(35)22(30-14)18-19(26)15(36-4)10-16(37-5)20(18)27/h6-11H,1H2,2-5H3,(H,29,34)(H,28,31,32)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.1 ng/ul of wild type FGFR-1 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM333151
PNG
(US10196436, Compound 3)
Show SMILES COc1cc(OC)cc(c1)N1CN(C)c2nc(SC)ncc2C1
Show InChI InChI=1S/C16H20N4O2S/c1-19-10-20(9-11-8-17-16(23-4)18-15(11)19)12-5-13(21-2)7-14(6-12)22-3/h5-8H,9-10H2,1-4H3
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.1 ng/ul of wild type FGFR-1 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM333153
PNG
(US10196436, Compound 5)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc(nc2N(C)C1=O)N(C)C(=O)C=C
Show InChI InChI=1S/C19H21N5O4/c1-6-16(25)22(2)18-20-10-12-11-24(19(26)23(3)17(12)21-18)13-7-14(27-4)9-15(8-13)28-5/h6-10H,1,11H2,2-5H3
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.1 ng/ul of wild type FGFR-1 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM333154
PNG
(US10196436, Compound 6)
Show SMILES COc1cc(OC)cc(c1)C#Cc1cnc(Nc2c(C)cccc2NC(=O)C=C)nc1
Show InChI InChI=1S/C24H22N4O3/c1-5-22(29)27-21-8-6-7-16(2)23(21)28-24-25-14-18(15-26-24)10-9-17-11-19(30-3)13-20(12-17)31-4/h5-8,11-15H,1H2,2-4H3,(H,27,29)(H,25,26,28)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.1 ng/ul of wild type FGFR-1 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM333155
PNG
(US10196436, Compound 7)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2nc(ncc2c1)N(C)C(=O)C=C
Show InChI InChI=1S/C20H17Cl2N3O3/c1-5-16(26)25(2)20-23-10-12-8-11(6-7-13(12)24-20)17-18(21)14(27-3)9-15(28-4)19(17)22/h5-10H,1H2,2-4H3
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.1 ng/ul of wild type FGFR-1 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM333166
PNG
(US10196436, Compound 17A)
Show SMILES COc1ccc(Cl)c(c1F)-c1ccc2nc(Nc3c(C)cccc3NC(=O)C=C)ncc2c1
Show InChI InChI=1S/C25H20ClFN4O2/c1-4-21(32)29-19-7-5-6-14(2)24(19)31-25-28-13-16-12-15(8-10-18(16)30-25)22-17(26)9-11-20(33-3)23(22)27/h4-13H,1H2,2-3H3,(H,29,32)(H,28,30,31)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.1 ng/ul of wild type FGFR-1 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM333167
PNG
(US10196436, Compound 18)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(Nc3c(C)cccc3NC(=O)C=C)cc2n(C)c1=O
Show InChI InChI=1S/C27H26N4O4/c1-6-25(32)29-22-9-7-8-16(2)26(22)30-24-14-23-18(15-28-24)12-21(27(33)31(23)3)17-10-19(34-4)13-20(11-17)35-5/h6-15H,1H2,2-5H3,(H,28,30)(H,29,32)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.1 ng/ul of wild type FGFR-1 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM333178
PNG
(US10196436, Compound 28)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2nc(Nc3c(C)cc(C)cc3NC(=O)C=C)ncc2c1
Show InChI InChI=1S/C27H24Cl2N4O3/c1-6-22(34)31-19-10-14(2)9-15(3)26(19)33-27-30-13-17-11-16(7-8-18(17)32-27)23-24(28)20(35-4)12-21(36-5)25(23)29/h6-13H,1H2,2-5H3,(H,31,34)(H,30,32,33)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.1 ng/ul of wild type FGFR-1 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM333182
PNG
(US10196436, Compound 32)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2nc(Nc3c(C)cc(F)cc3NC(=O)C=C)ncc2c1
Show InChI InChI=1S/C26H21Cl2FN4O3/c1-5-21(34)31-18-10-16(29)8-13(2)25(18)33-26-30-12-15-9-14(6-7-17(15)32-26)22-23(27)19(35-3)11-20(36-4)24(22)28/h5-12H,1H2,2-4H3,(H,31,34)(H,30,32,33)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.1 ng/ul of wild type FGFR-1 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM333205
PNG
(US10196436, Compound 54)
Show SMILES CN1CCC(CC1)NC(=O)c1ccc(Nc2ncc(C)c(n2)N2CCN(CC2)C(=O)Nc2ccc(cc2)C#N)c(NC(=O)C=C)c1
Show InChI InChI=1S/C33H38N10O3/c1-4-29(44)38-28-19-24(31(45)36-26-11-13-41(3)14-12-26)7-10-27(28)39-32-35-21-22(2)30(40-32)42-15-17-43(18-16-42)33(46)37-25-8-5-23(20-34)6-9-25/h4-10,19,21,26H,1,11-18H2,2-3H3,(H,36,45)(H,37,46)(H,38,44)(H,35,39,40)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.1 ng/ul of wild type FGFR-1 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM333158
PNG
(US10196436, Compound 10)
Show SMILES COc1cc(OC)cc(c1)-c1cnc2nc(Nc3c(C)cccc3NC(=O)C=C)ncc2c1
Show InChI InChI=1S/C25H23N5O3/c1-5-22(31)28-21-8-6-7-15(2)23(21)29-25-27-14-18-9-17(13-26-24(18)30-25)16-10-19(32-3)12-20(11-16)33-4/h5-14H,1H2,2-4H3,(H,28,31)(H,26,27,29,30)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.1 ng/ul of wild type FGFR-1 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM333171
PNG
(US10196436, Compound 22)
Show SMILES Cc1cccc(NC(=O)C=C)c1Nc1ncc2cc(-c3c(Cl)cccc3Cl)c(=O)n(C)c2n1
Show InChI InChI=1S/C24H19Cl2N5O2/c1-4-19(32)28-18-10-5-7-13(2)21(18)29-24-27-12-14-11-15(23(33)31(3)22(14)30-24)20-16(25)8-6-9-17(20)26/h4-12H,1H2,2-3H3,(H,28,32)(H,27,29,30)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.1 ng/ul of wild type FGFR-1 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM333190
PNG
(US10196436, Compound 40)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(Nc3ccccc3NC(=O)C=C)c(C)c2n(C)c1=O
Show InChI InChI=1S/C27H24Cl2N4O4/c1-6-21(34)31-17-9-7-8-10-18(17)32-26-14(2)25-15(13-30-26)11-16(27(35)33(25)3)22-23(28)19(36-4)12-20(37-5)24(22)29/h6-13H,1H2,2-5H3,(H,30,32)(H,31,34)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.1 ng/ul of wild type FGFR-1 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM333150
PNG
(US10196436, Compound 2)
Show SMILES CN(C(=O)C=C)c1ncc2cc(ccc2n1)-c1c(Cl)cccc1Cl
Show InChI InChI=1S/C18H13Cl2N3O/c1-3-16(24)23(2)18-21-10-12-9-11(7-8-15(12)22-18)17-13(19)5-4-6-14(17)20/h3-10H,1H2,2H3
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.1 ng/ul of wild type FGFR-1 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM333158
PNG
(US10196436, Compound 10)
Show SMILES COc1cc(OC)cc(c1)-c1cnc2nc(Nc3c(C)cccc3NC(=O)C=C)ncc2c1
Show InChI InChI=1S/C25H23N5O3/c1-5-22(31)28-21-8-6-7-15(2)23(21)29-25-27-14-18-9-17(13-26-24(18)30-25)16-10-19(32-3)12-20(11-16)33-4/h5-14H,1H2,2-4H3,(H,28,31)(H,26,27,29,30)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM333168
PNG
(US10196436, Compound 19)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(Nc3c(C)cccc3NC(=O)C=C)nc2n(C)c1=O
Show InChI InChI=1S/C26H25N5O4/c1-6-22(32)28-21-9-7-8-15(2)23(21)29-26-27-14-17-12-20(25(33)31(3)24(17)30-26)16-10-18(34-4)13-19(11-16)35-5/h6-14H,1H2,2-5H3,(H,28,32)(H,27,29,30)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.1 ng/ul of wild type FGFR-1 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM333169
PNG
(US10196436, Compound 20)
Show SMILES CC(C)Oc1cc(NC(=O)NCC(F)(F)F)cc(c1)-c1cnc2c(CNC(=O)C#C)cccn12
Show InChI InChI=1S/C23H22F3N5O3/c1-4-20(32)27-11-15-6-5-7-31-19(12-28-21(15)31)16-8-17(10-18(9-16)34-14(2)3)30-22(33)29-13-23(24,25)26/h1,5-10,12,14H,11,13H2,2-3H3,(H,27,32)(H2,29,30,33)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.1 ng/ul of wild type FGFR-1 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM333183
PNG
(US10196436, Compound 33)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2nc(Nc3c(C)c(F)ccc3NC(=O)C=C)ncc2c1
Show InChI InChI=1S/C26H21Cl2FN4O3/c1-5-21(34)31-18-9-7-16(29)13(2)25(18)33-26-30-12-15-10-14(6-8-17(15)32-26)22-23(27)19(35-3)11-20(36-4)24(22)28/h5-12H,1H2,2-4H3,(H,31,34)(H,30,32,33)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.1 ng/ul of wild type FGFR-1 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM333186
PNG
(US10196436, Compound 36)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2nc(Nc3c(F)cc(F)cc3NC(=O)C=C)ncc2c1
Show InChI InChI=1S/C25H18Cl2F2N4O3/c1-4-20(34)31-17-9-14(28)8-15(29)24(17)33-25-30-11-13-7-12(5-6-16(13)32-25)21-22(26)18(35-2)10-19(36-3)23(21)27/h4-11H,1H2,2-3H3,(H,31,34)(H,30,32,33)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.1 ng/ul of wild type FGFR-1 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM333152
PNG
(US10196436, Compound 4)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc(SC)nc2N(C)C1=O
Show InChI InChI=1S/C16H18N4O3S/c1-19-14-10(8-17-15(18-14)24-4)9-20(16(19)21)11-5-12(22-2)7-13(6-11)23-3/h5-8H,9H2,1-4H3
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.1 ng/ul of wild type FGFR-1 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM333173
PNG
(US10196436, Compound 24)
Show SMILES COc1cc(OC)c(Cl)c(C#Cc2cnc(Nc3c(C)cccc3NC(=O)C=C)nc2)c1Cl
Show InChI InChI=1S/C24H20Cl2N4O3/c1-5-20(31)29-17-8-6-7-14(2)23(17)30-24-27-12-15(13-28-24)9-10-16-21(25)18(32-3)11-19(33-4)22(16)26/h5-8,11-13H,1H2,2-4H3,(H,29,31)(H,27,28,30)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.1 ng/ul of wild type FGFR-1 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM333194
PNG
(US10196436, Compound 44)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(Nc3ccccc3NC(=O)C=C)cc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C30H32N6O4/c1-7-27(37)33-24-11-9-8-10-23(24)32-26-16-25-19(17-31-26)14-22(18-12-20(39-5)15-21(13-18)40-6)28(34-25)35-29(38)36-30(2,3)4/h7-17H,1H2,2-6H3,(H,31,32)(H,33,37)(H2,34,35,36,38)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.1 ng/ul of wild type FGFR-1 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM333157
PNG
(US10196436, Compound 9)
Show SMILES Cc1cccc(NC(=O)C=C)c1Nc1ncc2cc(ccc2n1)-c1cc(ccc1F)C(N)=O
Show InChI InChI=1S/C25H20FN5O2/c1-3-22(32)29-21-6-4-5-14(2)23(21)31-25-28-13-17-11-15(8-10-20(17)30-25)18-12-16(24(27)33)7-9-19(18)26/h3-13H,1H2,2H3,(H2,27,33)(H,29,32)(H,28,30,31)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.1 ng/ul of wild type FGFR-1 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM333177
PNG
(US10196436, Compound 27 | US10196436, Compound 51)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2nc(Nc3c(F)cccc3NC(=O)C=C)ncc2c1
Show InChI InChI=1S/C25H19Cl2FN4O3/c1-4-20(33)30-17-7-5-6-15(28)24(17)32-25-29-12-14-10-13(8-9-16(14)31-25)21-22(26)18(34-2)11-19(35-3)23(21)27/h4-12H,1H2,2-3H3,(H,30,33)(H,29,31,32)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.1 ng/ul of wild type FGFR-1 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM333161
PNG
(US10196436, Compound 13)
Show SMILES Cc1cccc(NC(=O)C=C)c1Nc1ncc2cc(ccc2n1)-c1c(Cl)cccc1Cl
Show InChI InChI=1S/C24H18Cl2N4O/c1-3-21(31)28-20-9-4-6-14(2)23(20)30-24-27-13-16-12-15(10-11-19(16)29-24)22-17(25)7-5-8-18(22)26/h3-13H,1H2,2H3,(H,28,31)(H,27,29,30)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.1 ng/ul of wild type FGFR-1 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM333163
PNG
(US10196436, Compound 15)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(Nc3ccccc3NC(=O)C=C)cc2n(C)c1=O
Show InChI InChI=1S/C26H24N4O4/c1-5-25(31)29-22-9-7-6-8-21(22)28-24-14-23-17(15-27-24)12-20(26(32)30(23)2)16-10-18(33-3)13-19(11-16)34-4/h5-15H,1H2,2-4H3,(H,27,28)(H,29,31)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.1 ng/ul of wild type FGFR-1 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM333164
PNG
(US10196436, Compound 16)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(Nc3ccccc3NC(=O)C=C)nc2n(C)c1=O
Show InChI InChI=1S/C25H23N5O4/c1-5-22(31)27-20-8-6-7-9-21(20)28-25-26-14-16-12-19(24(32)30(2)23(16)29-25)15-10-17(33-3)13-18(11-15)34-4/h5-14H,1H2,2-4H3,(H,27,31)(H,26,28,29)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.1 ng/ul of wild type FGFR-1 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM333188
PNG
(Synthesis of N-(2-(3-(3-isopropoxy-5-(3-(2,2,2-tri...)
Show SMILES CC(C)Oc1cc(NC(=O)NCC(F)(F)F)cc(c1)-c1cnc2cc(ccn12)-c1ccccc1NC(=O)C=C
Show InChI InChI=1S/C28H26F3N5O3/c1-4-26(37)35-23-8-6-5-7-22(23)18-9-10-36-24(15-32-25(36)13-18)19-11-20(14-21(12-19)39-17(2)3)34-27(38)33-16-28(29,30)31/h4-15,17H,1,16H2,2-3H3,(H,35,37)(H2,33,34,38)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.1 ng/ul of wild type FGFR-1 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM333170
PNG
(US10196436, Compound 21)
Show SMILES FC(F)(F)CNC(=O)Nc1cccc(c1)-c1cnc2cc(ccn12)-c1ccccc1NC(=O)C=C
Show InChI InChI=1S/C25H20F3N5O2/c1-2-23(34)32-20-9-4-3-8-19(20)16-10-11-33-21(14-29-22(33)13-16)17-6-5-7-18(12-17)31-24(35)30-15-25(26,27)28/h2-14H,1,15H2,(H,32,34)(H2,30,31,35)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.1 ng/ul of wild type FGFR-1 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...


US Patent US10196436 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%