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Patent code US10201527

Compile Data Set for Download or QSAR
Found 144 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histone deacetylase 1


(Homo sapiens (Human))
BDBM50248570
PNG
(3-(1-(3-(dimethylamino)-2,2-dimethylpropyl)-2-phen...)
Show SMILES CN(C)CC(C)(C)Cn1c(CCc2ccccc2)nc2cc(\C=C\C(=O)NO)ccc12
Show InChI InChI=1S/C25H32N4O2/c1-25(2,17-28(3)4)18-29-22-13-10-20(12-15-24(30)27-31)16-21(22)26-23(29)14-11-19-8-6-5-7-9-19/h5-10,12-13,15-16,31H,11,14,17-18H2,1-4H3,(H,27,30)/b15-12+
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US Patent
n/an/a 24n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM50248375
PNG
(CHEMBL491688 | N-hydroxy-3-(2-phenethyl-1-(3,4,5-t...)
Show SMILES COc1cc(Cn2c(CCc3ccccc3)nc3cc(\C=C\C(=O)NO)ccc23)cc(OC)c1OC
Show InChI InChI=1S/C28H29N3O5/c1-34-24-16-21(17-25(35-2)28(24)36-3)18-31-23-12-9-20(11-14-27(32)30-33)15-22(23)29-26(31)13-10-19-7-5-4-6-8-19/h4-9,11-12,14-17,33H,10,13,18H2,1-3H3,(H,30,32)/b14-11+
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n/an/a 26n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM338996
PNG
(US10201527, Compound 91)
Show SMILES CN(C)CC(C)(C)Cn1c(nc2cc(\C=C\C(=O)NO)ccc12)S(=O)Cc1ccccc1
Show InChI InChI=1S/C24H30N4O3S/c1-24(2,16-27(3)4)17-28-21-12-10-18(11-13-22(29)26-30)14-20(21)25-23(28)32(31)15-19-8-6-5-7-9-19/h5-14,30H,15-17H2,1-4H3,(H,26,29)/b13-11+
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n/an/a 30n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM50248522
PNG
(CHEMBL489332 | N-hydroxy-3-(2-phenethyl-1-(2-(pipe...)
Show SMILES ONC(=O)\C=C\c1ccc2n(CCN3CCCCC3)c(CCc3ccccc3)nc2c1
Show InChI InChI=1S/C25H30N4O2/c30-25(27-31)14-11-21-9-12-23-22(19-21)26-24(13-10-20-7-3-1-4-8-20)29(23)18-17-28-15-5-2-6-16-28/h1,3-4,7-9,11-12,14,19,31H,2,5-6,10,13,15-18H2,(H,27,30)/b14-11+
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n/an/a 39n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM50248314
PNG
(CHEMBL474746 | N-hydroxy-3-(1-(3-hydroxypropyl)-2-...)
Show SMILES CC(Cc1nc2cc(\C=C\C(=O)NO)ccc2n1CCCO)c1ccccc1
Show InChI InChI=1S/C22H25N3O3/c1-16(18-6-3-2-4-7-18)14-21-23-19-15-17(9-11-22(27)24-28)8-10-20(19)25(21)12-5-13-26/h2-4,6-11,15-16,26,28H,5,12-14H2,1H3,(H,24,27)/b11-9+
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n/an/a 51n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM103600
PNG
(US10201527, Compound 94 | US8551988, 94)
Show SMILES COc1cccc(CCc2nc3cc(\C=C\C(=O)NO)ccc3n2CC(C)(C)CN(C)C)c1
Show InChI InChI=1S/C26H34N4O3/c1-26(2,17-29(3)4)18-30-23-12-9-20(11-14-25(31)28-32)16-22(23)27-24(30)13-10-19-7-6-8-21(15-19)33-5/h6-9,11-12,14-16,32H,10,13,17-18H2,1-5H3,(H,28,31)/b14-11+
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n/an/a 52n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM50248476
PNG
(CHEMBL491316 | N-hydroxy-3-(2-phenethyl-1-(2-(pyrr...)
Show SMILES ONC(=O)\C=C\c1ccc2n(CCN3CCCC3)c(CCc3ccccc3)nc2c1
Show InChI InChI=1S/C24H28N4O2/c29-24(26-30)13-10-20-8-11-22-21(18-20)25-23(12-9-19-6-2-1-3-7-19)28(22)17-16-27-14-4-5-15-27/h1-3,6-8,10-11,13,18,30H,4-5,9,12,14-17H2,(H,26,29)/b13-10+
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n/an/a 52n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM103590
PNG
(US10201527, Compound 84 | US8551988, 84)
Show SMILES CN(C)CC(C)(C)Cn1c(CCc2ccc(F)cc2)nc2cc(\C=C\C(=O)NO)ccc12
Show InChI InChI=1S/C25H31FN4O2/c1-25(2,16-29(3)4)17-30-22-12-7-19(9-14-24(31)28-32)15-21(22)27-23(30)13-8-18-5-10-20(26)11-6-18/h5-7,9-12,14-15,32H,8,13,16-17H2,1-4H3,(H,28,31)/b14-9+
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n/an/a 54n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM339000
PNG
(US10201527, Compound 95)
Show SMILES COc1cccc(CCc2nc3cc(\C=C\C(=O)NO)ccc3[nH]2)c1
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n/an/a 61n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM338970
PNG
(US10201527, Compound 65)
Show SMILES Cn1c(Cc2ccccc2)n(=O)c2cc(\C=C\C(=O)NO)ccc12
Show InChI InChI=1S/C18H17N3O3/c1-20-15-9-7-14(8-10-17(22)19-23)11-16(15)21(24)18(20)12-13-5-3-2-4-6-13/h2-11,23H,12H2,1H3,(H,19,22)/b10-8+
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n/an/a 62n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM50248261
PNG
(CHEMBL475145 | N-hydroxy-3-(1-(3-hydroxypropyl)-2-...)
Show SMILES CC(C)Cc1nc2cc(\C=C\C(=O)NO)ccc2n1CCCO
Show InChI InChI=1S/C17H23N3O3/c1-12(2)10-16-18-14-11-13(5-7-17(22)19-23)4-6-15(14)20(16)8-3-9-21/h4-7,11-12,21,23H,3,8-10H2,1-2H3,(H,19,22)/b7-5+
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n/an/a 64n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM103599
PNG
(US10201527, Compound 93 | US8551988, 93)
Show SMILES CCn1c(CCCc2c[nH]c3ccccc23)nc2cc(\C=C\C(=O)NO)ccc12
Show InChI InChI=1S/C23H24N4O2/c1-2-27-21-12-10-16(11-13-23(28)26-29)14-20(21)25-22(27)9-5-6-17-15-24-19-8-4-3-7-18(17)19/h3-4,7-8,10-15,24,29H,2,5-6,9H2,1H3,(H,26,28)/b13-11+
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n/an/a 65n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM103589
PNG
(US10201527, Compound 83 | US8551988, 83)
Show SMILES CN(C)CC(C)(C)Cn1c(CCCc2ccccc2)nc2cc(\C=C\C(=O)NO)ccc12
Show InChI InChI=1S/C26H34N4O2/c1-26(2,18-29(3)4)19-30-23-15-13-21(14-16-25(31)28-32)17-22(23)27-24(30)12-8-11-20-9-6-5-7-10-20/h5-7,9-10,13-17,32H,8,11-12,18-19H2,1-4H3,(H,28,31)/b16-14+
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n/an/a 71n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM50248475
PNG
(3-(1-(2-(diethylamino)ethyl)-2-phenethyl-1H-benzo[...)
Show SMILES CCN(CC)CCn1c(CCc2ccccc2)nc2cc(\C=C\C(=O)NO)ccc12
Show InChI InChI=1S/C24H30N4O2/c1-3-27(4-2)16-17-28-22-13-10-20(12-15-24(29)26-30)18-21(22)25-23(28)14-11-19-8-6-5-7-9-19/h5-10,12-13,15,18,30H,3-4,11,14,16-17H2,1-2H3,(H,26,29)/b15-12+
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n/an/a 72n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM103547
PNG
(US10201527, Compound 27 | US8551988, 27)
Show SMILES ONC(=O)\C=C\c1ccc2n(CCc3cccnc3)c(CCc3ccccc3)nc2c1
Show InChI InChI=1S/C25H24N4O2/c30-25(28-31)13-10-20-8-11-23-22(17-20)27-24(12-9-19-5-2-1-3-6-19)29(23)16-14-21-7-4-15-26-18-21/h1-8,10-11,13,15,17-18,31H,9,12,14,16H2,(H,28,30)/b13-10+
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n/an/a 92n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM338959
PNG
(US10201527, Compound 54)
Show SMILES Cn1c(CNC(=O)Cc2ccccc2)nc2cc(\C=C\C(=O)NO)ccc12
Show InChI InChI=1S/C20H20N4O3/c1-24-17-9-7-15(8-10-19(25)23-27)11-16(17)22-18(24)13-21-20(26)12-14-5-3-2-4-6-14/h2-11,27H,12-13H2,1H3,(H,21,26)(H,23,25)/b10-8+
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n/an/a 100n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM235
PNG
(US10201527, Compound 60 | US8551988, 60)
Show SMILES Cn1c(CNCc2ccccc2)nc2cc(\C=C\C(=O)NO)ccc12
Show InChI InChI=1S/C19H20N4O2/c1-23-17-9-7-14(8-10-19(24)22-25)11-16(17)21-18(23)13-20-12-15-5-3-2-4-6-15/h2-11,20,25H,12-13H2,1H3,(H,22,24)/b10-8+
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n/an/a 116n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM103595
PNG
(US10201527, Compound 89 | US8551988, 89)
Show SMILES CN(C)CC(C)(C)Cn1c(SCc2ccccc2)nc2cc(\C=C\C(=O)NO)ccc12
Show InChI InChI=1S/C24H30N4O2S/c1-24(2,16-27(3)4)17-28-21-12-10-18(11-13-22(29)26-30)14-20(21)25-23(28)31-15-19-8-6-5-7-9-19/h5-14,30H,15-17H2,1-4H3,(H,26,29)/b13-11+
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n/an/a 116n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM50248314
PNG
(CHEMBL474746 | N-hydroxy-3-(1-(3-hydroxypropyl)-2-...)
Show SMILES CC(Cc1nc2cc(\C=C\C(=O)NO)ccc2n1CCCO)c1ccccc1
Show InChI InChI=1S/C22H25N3O3/c1-16(18-6-3-2-4-7-18)14-21-23-19-15-17(9-11-22(27)24-28)8-10-20(19)25(21)12-5-13-26/h2-4,6-11,15-16,26,28H,5,12-14H2,1H3,(H,24,27)/b11-9+
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n/an/a 119n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
To determine EC50 where acetylated histone 3 was induced by 50%, Colo205 cells was cultivated in 96 well plate at 1.5105 cells/well for 24 h. Colo20...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM103602
PNG
(US10201527, Compound 96 | US8551988, 96)
Show SMILES CCn1c(CCCOc2ccccc2)nc2cc(\C=C\C(=O)NO)ccc12
Show InChI InChI=1S/C21H23N3O3/c1-2-24-19-12-10-16(11-13-21(25)23-26)15-18(19)22-20(24)9-6-14-27-17-7-4-3-5-8-17/h3-5,7-8,10-13,15,26H,2,6,9,14H2,1H3,(H,23,25)/b13-11+
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n/an/a 125n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM338990
PNG
(US10201527, Compound 85)
Show SMILES ONC(=O)\C=C\c1ccc2[nH]c(CCc3ccc(F)cc3)nc2c1
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n/an/a 131n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM103542
PNG
(US10201527, Compound 12 | US8551988, 12)
Show SMILES ONC(=O)\C=C\c1ccc2n(Cc3cccnc3)c(CCc3ccccc3)nc2c1
Show InChI InChI=1S/C24H22N4O2/c29-24(27-30)13-10-19-8-11-22-21(15-19)26-23(12-9-18-5-2-1-3-6-18)28(22)17-20-7-4-14-25-16-20/h1-8,10-11,13-16,30H,9,12,17H2,(H,27,29)/b13-10+
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n/an/a 131n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM338960
PNG
(US10201527, Compound 55)
Show SMILES Cn1c(CNC(=O)c2ccncc2)nc2cc(\C=C\C(=O)NO)ccc12
Show InChI InChI=1S/C18H17N5O3/c1-23-15-4-2-12(3-5-17(24)22-26)10-14(15)21-16(23)11-20-18(25)13-6-8-19-9-7-13/h2-10,26H,11H2,1H3,(H,20,25)(H,22,24)/b5-3+
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n/an/a 137n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM103543
PNG
(US10201527, Compound 13 | US8551988, 13)
Show SMILES OCCCn1c(nc2cc(\C=C\C(=O)NO)ccc12)-c1ccccn1
Show InChI InChI=1S/C18H18N4O3/c23-11-3-10-22-16-7-5-13(6-8-17(24)21-25)12-15(16)20-18(22)14-4-1-2-9-19-14/h1-2,4-9,12,23,25H,3,10-11H2,(H,21,24)/b8-6+
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n/an/a 141n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
To determine EC50 where acetylated histone 3 was induced by 50%, Colo205 cells was cultivated in 96 well plate at 1.5105 cells/well for 24 h. Colo20...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM50248315
PNG
(3-(2-(benzyloxymethyl)-1-(3-hydroxypropyl)-1H-benz...)
Show SMILES OCCCn1c(COCc2ccccc2)nc2cc(\C=C\C(=O)NO)ccc12
Show InChI InChI=1S/C21H23N3O4/c25-12-4-11-24-19-9-7-16(8-10-21(26)23-27)13-18(19)22-20(24)15-28-14-17-5-2-1-3-6-17/h1-3,5-10,13,25,27H,4,11-12,14-15H2,(H,23,26)/b10-8+
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n/an/a 145n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
To determine EC50 where acetylated histone 3 was induced by 50%, Colo205 cells was cultivated in 96 well plate at 1.5105 cells/well for 24 h. Colo20...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM240
PNG
(US10201527, Compound 69 | US8551988, 69)
Show SMILES Cn1c(CNC(=O)Cc2ccc(F)cc2)nc2cc(\C=C\C(=O)NO)ccc12
Show InChI InChI=1S/C20H19FN4O3/c1-25-17-8-4-13(5-9-19(26)24-28)10-16(17)23-18(25)12-22-20(27)11-14-2-6-15(21)7-3-14/h2-10,28H,11-12H2,1H3,(H,22,27)(H,24,26)/b9-5+
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n/an/a 146n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM50248376
PNG
(3-(1-ethyl-2-phenethyl-1H-benzo[d]imidazol-5-yl)-N...)
Show SMILES CCn1c(CCc2ccccc2)nc2cc(\C=C\C(=O)NO)ccc12
Show InChI InChI=1S/C20H21N3O2/c1-2-23-18-11-8-16(10-13-20(24)22-25)14-17(18)21-19(23)12-9-15-6-4-3-5-7-15/h3-8,10-11,13-14,25H,2,9,12H2,1H3,(H,22,24)/b13-10+
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n/an/a 148n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
To determine EC50 where acetylated histone 3 was induced by 50%, Colo205 cells was cultivated in 96 well plate at 1.5105 cells/well for 24 h. Colo20...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM50248256
PNG
(3-(1-(4-(dimethylamino)butyl)-2-phenethyl-1H-benzo...)
Show SMILES CN(C)CCCCn1c(CCc2ccccc2)nc2cc(\C=C\C(=O)NO)ccc12
Show InChI InChI=1S/C24H30N4O2/c1-27(2)16-6-7-17-28-22-13-10-20(12-15-24(29)26-30)18-21(22)25-23(28)14-11-19-8-4-3-5-9-19/h3-5,8-10,12-13,15,18,30H,6-7,11,14,16-17H2,1-2H3,(H,26,29)/b15-12+
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n/an/a 153n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM50248524
PNG
(3-(1-(3-(1H-imidazol-1-yl)propyl)-2-phenethyl-1H-b...)
Show SMILES ONC(=O)\C=C\c1ccc2n(CCCn3ccnc3)c(CCc3ccccc3)nc2c1
Show InChI InChI=1S/C24H25N5O2/c30-24(27-31)12-9-20-7-10-22-21(17-20)26-23(11-8-19-5-2-1-3-6-19)29(22)15-4-14-28-16-13-25-18-28/h1-3,5-7,9-10,12-13,16-18,31H,4,8,11,14-15H2,(H,27,30)/b12-9+
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n/an/a 158n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM338946
PNG
(US10201527, Compound 41)
Show SMILES CC(Cc1nc2cc(\C=C\C(=O)NO)ccc2n1CCc1cccnc1)c1ccccc1
Show InChI InChI=1S/C26H26N4O2/c1-19(22-7-3-2-4-8-22)16-25-28-23-17-20(10-12-26(31)29-32)9-11-24(23)30(25)15-13-21-6-5-14-27-18-21/h2-12,14,17-19,32H,13,15-16H2,1H3,(H,29,31)/b12-10+
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n/an/a 159n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
To determine EC50 where acetylated histone 3 was induced by 50%, Colo205 cells was cultivated in 96 well plate at 1.5105 cells/well for 24 h. Colo20...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM338957
PNG
(US10201527, Compound 52)
Show SMILES Cn1c(CCCc2ccccc2)nc2cc(\C=C\C(=O)NO)ccc12
Show InChI InChI=1S/C20H21N3O2/c1-23-18-12-10-16(11-13-20(24)22-25)14-17(18)21-19(23)9-5-8-15-6-3-2-4-7-15/h2-4,6-7,10-14,25H,5,8-9H2,1H3,(H,22,24)/b13-11+
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n/an/a 160n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM103541
PNG
(US10201527, Compound 11 | US8551988, 11)
Show SMILES OCCCn1c(nc2cc(\C=C\C(=O)NO)ccc12)-c1ccncc1
Show InChI InChI=1S/C18H18N4O3/c23-11-1-10-22-16-4-2-13(3-5-17(24)21-25)12-15(16)20-18(22)14-6-8-19-9-7-14/h2-9,12,23,25H,1,10-11H2,(H,21,24)/b5-3+
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n/an/a 161n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
To determine EC50 where acetylated histone 3 was induced by 50%, Colo205 cells was cultivated in 96 well plate at 1.5105 cells/well for 24 h. Colo20...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM50248525
PNG
(3-(1-(3-(dimethylamino)propyl)-2-phenethyl-1H-benz...)
Show SMILES CN(C)CCCn1c(CCc2ccccc2)nc2cc(\C=C\C(=O)NO)ccc12
Show InChI InChI=1S/C23H28N4O2/c1-26(2)15-6-16-27-21-12-9-19(11-14-23(28)25-29)17-20(21)24-22(27)13-10-18-7-4-3-5-8-18/h3-5,7-9,11-12,14,17,29H,6,10,13,15-16H2,1-2H3,(H,25,28)/b14-11+
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n/an/a 162n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM50248315
PNG
(3-(2-(benzyloxymethyl)-1-(3-hydroxypropyl)-1H-benz...)
Show SMILES OCCCn1c(COCc2ccccc2)nc2cc(\C=C\C(=O)NO)ccc12
Show InChI InChI=1S/C21H23N3O4/c25-12-4-11-24-19-9-7-16(8-10-21(26)23-27)13-18(19)22-20(24)15-28-14-17-5-2-1-3-6-17/h1-3,5-10,13,25,27H,4,11-12,14-15H2,(H,23,26)/b10-8+
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n/an/a 165n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM103596
PNG
(US10201527, Compound 90 | US8551988, 90)
Show SMILES ONC(=O)\C=C\c1ccc2n(CCN3CCCCC3)cnc2c1
Show InChI InChI=1S/C17H22N4O2/c22-17(19-23)7-5-14-4-6-16-15(12-14)18-13-21(16)11-10-20-8-2-1-3-9-20/h4-7,12-13,23H,1-3,8-11H2,(H,19,22)/b7-5+
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n/an/a 166n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM245
PNG
(US10201527, Compound 71 | US8551988, 71)
Show SMILES CCn1c(CCNS(=O)(=O)c2ccccc2)nc2cc(\C=C\C(=O)NO)ccc12
Show InChI InChI=1S/C20H22N4O4S/c1-2-24-18-10-8-15(9-11-20(25)23-26)14-17(18)22-19(24)12-13-21-29(27,28)16-6-4-3-5-7-16/h3-11,14,21,26H,2,12-13H2,1H3,(H,23,25)/b11-9+
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n/an/a 167n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM50248573
PNG
(CHEMBL464719 | N-hydroxy-3-(2-phenethyl-1-(3,4,5-t...)
Show SMILES COc1cc(Cn2c(CCc3ccccc3)nc3cc(CCC(=O)NO)ccc23)cc(OC)c1OC
Show InChI InChI=1S/C28H31N3O5/c1-34-24-16-21(17-25(35-2)28(24)36-3)18-31-23-12-9-20(11-14-27(32)30-33)15-22(23)29-26(31)13-10-19-7-5-4-6-8-19/h4-9,12,15-17,33H,10-11,13-14,18H2,1-3H3,(H,30,32)
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n/an/a 167n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM103598
PNG
(US10201527, Compound 92 | US8551988, 92)
Show SMILES CCn1c(Cc2ccccc2)nc2cc(\C=C\C(=O)NO)ccc12
Show InChI InChI=1S/C19H19N3O2/c1-2-22-17-10-8-15(9-11-19(23)21-24)12-16(17)20-18(22)13-14-6-4-3-5-7-14/h3-12,24H,2,13H2,1H3,(H,21,23)/b11-9+
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n/an/a 168n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM103534
PNG
(CHEMBL474152 | US10201527, Compound 40 | US8551988...)
Show SMILES OCCCn1c(CCc2ccccc2)nc2cc(\C=C\C(=O)NO)ccc12
Show InChI InChI=1S/C21H23N3O3/c25-14-4-13-24-19-10-7-17(9-12-21(26)23-27)15-18(19)22-20(24)11-8-16-5-2-1-3-6-16/h1-3,5-7,9-10,12,15,25,27H,4,8,11,13-14H2,(H,23,26)/b12-9+
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n/an/a 171n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM338955
PNG
(US10201527, Compound 50)
Show SMILES ONC(=O)\C=C\c1ccc2[nH]c(CCc3ccccc3)nc2c1
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n/an/a 173n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM246
PNG
(US10201527, Compound 43 | US8551988, 43)
Show SMILES CCn1c(C)nc2cc(\C=C\C(=O)NO)ccc12
Show InChI InChI=1S/C13H15N3O2/c1-3-16-9(2)14-11-8-10(4-6-12(11)16)5-7-13(17)15-18/h4-8,18H,3H2,1-2H3,(H,15,17)/b7-5+
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n/an/a 192n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
To determine EC50 where acetylated histone 3 was induced by 50%, Colo205 cells was cultivated in 96 well plate at 1.5105 cells/well for 24 h. Colo20...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM50247927
PNG
(CHEMBL489706 | N-hydroxy-3-(2-phenethyl-1-(pyridin...)
Show SMILES ONC(=O)\C=C\c1ccc2n(Cc3ccccn3)c(CCc3ccccc3)nc2c1
Show InChI InChI=1S/C24H22N4O2/c29-24(27-30)14-11-19-9-12-22-21(16-19)26-23(13-10-18-6-2-1-3-7-18)28(22)17-20-8-4-5-15-25-20/h1-9,11-12,14-16,30H,10,13,17H2,(H,27,29)/b14-11+
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n/an/a 194n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM338946
PNG
(US10201527, Compound 41)
Show SMILES CC(Cc1nc2cc(\C=C\C(=O)NO)ccc2n1CCc1cccnc1)c1ccccc1
Show InChI InChI=1S/C26H26N4O2/c1-19(22-7-3-2-4-8-22)16-25-28-23-17-20(10-12-26(31)29-32)9-11-24(23)30(25)15-13-21-6-5-14-27-18-21/h2-12,14,17-19,32H,13,15-16H2,1H3,(H,29,31)/b12-10+
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n/an/a 195n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM50248473
PNG
(CHEMBL523646 | N-hydroxy-3-(1-(3-(2-oxopyrrolidin-...)
Show SMILES ONC(=O)\C=C\c1ccc2n(CCCN3CCCC3=O)c(CCc3ccccc3)nc2c1
Show InChI InChI=1S/C25H28N4O3/c30-24(27-32)14-11-20-9-12-22-21(18-20)26-23(13-10-19-6-2-1-3-7-19)29(22)17-5-16-28-15-4-8-25(28)31/h1-3,6-7,9,11-12,14,18,32H,4-5,8,10,13,15-17H2,(H,27,30)/b14-11+
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n/an/a 195n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM645
PNG
(US10201527, Compound 61 | US8551988, 61)
Show SMILES Cn1c(CN(Cc2ccccc2)Cc2ccccc2)nc2cc(\C=C\C(=O)NO)ccc12
Show InChI InChI=1S/C26H26N4O2/c1-29-24-14-12-20(13-15-26(31)28-32)16-23(24)27-25(29)19-30(17-21-8-4-2-5-9-21)18-22-10-6-3-7-11-22/h2-16,32H,17-19H2,1H3,(H,28,31)/b15-13+
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n/an/a 196n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM338944
PNG
(US10201527, Compound 39)
Show SMILES CCn1cnc2cc(\C=C\C(=O)NO)ccc12
Show InChI InChI=1S/C12H13N3O2/c1-2-15-8-13-10-7-9(3-5-11(10)15)4-6-12(16)14-17/h3-8,17H,2H2,1H3,(H,14,16)/b6-4+
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n/an/a 201n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
To determine EC50 where acetylated histone 3 was induced by 50%, Colo205 cells was cultivated in 96 well plate at 1.5105 cells/well for 24 h. Colo20...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM103542
PNG
(US10201527, Compound 12 | US8551988, 12)
Show SMILES ONC(=O)\C=C\c1ccc2n(Cc3cccnc3)c(CCc3ccccc3)nc2c1
Show InChI InChI=1S/C24H22N4O2/c29-24(27-30)13-10-19-8-11-22-21(15-19)26-23(12-9-18-5-2-1-3-6-18)28(22)17-20-7-4-14-25-16-20/h1-8,10-11,13-16,30H,9,12,17H2,(H,27,29)/b13-10+
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n/an/a 202n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
To determine EC50 where acetylated histone 3 was induced by 50%, Colo205 cells was cultivated in 96 well plate at 1.5105 cells/well for 24 h. Colo20...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM50248258
PNG
(3-(2-cyclohexyl-1-(3-hydroxypropyl)-1H-benzo[d]imi...)
Show SMILES OCCCn1c(nc2cc(\C=C\C(=O)NO)ccc12)C1CCCCC1
Show InChI InChI=1S/C19H25N3O3/c23-12-4-11-22-17-9-7-14(8-10-18(24)21-25)13-16(17)20-19(22)15-5-2-1-3-6-15/h7-10,13,15,23,25H,1-6,11-12H2,(H,21,24)/b10-8+
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n/an/a 203n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
To determine EC50 where acetylated histone 3 was induced by 50%, Colo205 cells was cultivated in 96 well plate at 1.5105 cells/well for 24 h. Colo20...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM50248432
PNG
(CHEMBL521909 | N-hydroxy-3-(1-(3-methoxypropyl)-2-...)
Show SMILES COCCCn1c(CCc2ccccc2)nc2cc(\C=C\C(=O)NO)ccc12
Show InChI InChI=1S/C22H25N3O3/c1-28-15-5-14-25-20-11-8-18(10-13-22(26)24-27)16-19(20)23-21(25)12-9-17-6-3-2-4-7-17/h2-4,6-8,10-11,13,16,27H,5,9,12,14-15H2,1H3,(H,24,26)/b13-10+
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n/an/a 206n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM103548
PNG
(US10201527, Compound 28 | US8551988, 28)
Show SMILES ONC(=O)\C=C\c1ccc2n(CCc3cccnc3)c(COCc3ccccc3)nc2c1
Show InChI InChI=1S/C25H24N4O3/c30-25(28-31)11-9-19-8-10-23-22(15-19)27-24(18-32-17-21-5-2-1-3-6-21)29(23)14-12-20-7-4-13-26-16-20/h1-11,13,15-16,31H,12,14,17-18H2,(H,28,30)/b11-9+
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n/an/a 206n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM50248376
PNG
(3-(1-ethyl-2-phenethyl-1H-benzo[d]imidazol-5-yl)-N...)
Show SMILES CCn1c(CCc2ccccc2)nc2cc(\C=C\C(=O)NO)ccc12
Show InChI InChI=1S/C20H21N3O2/c1-2-23-18-11-8-16(10-13-20(24)22-25)14-17(18)21-19(23)12-9-15-6-4-3-5-7-15/h3-8,10-11,13-14,25H,2,9,12H2,1H3,(H,22,24)/b13-10+
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n/an/a 218n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM50248431
PNG
(CHEMBL489125 | N-hydroxy-3-(2-phenethyl-1-propyl-1...)
Show SMILES CCCn1c(CCc2ccccc2)nc2cc(\C=C\C(=O)NO)ccc12
Show InChI InChI=1S/C21H23N3O2/c1-2-14-24-19-11-8-17(10-13-21(25)23-26)15-18(19)22-20(24)12-9-16-6-4-3-5-7-16/h3-8,10-11,13,15,26H,2,9,12,14H2,1H3,(H,23,25)/b13-10+
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n/an/a 227n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM338969
PNG
(US10201527, Compound 64)
Show SMILES CCn1c(CNCc2ccccc2)nc2cc(\C=C\C(=O)NO)ccc12
Show InChI InChI=1S/C20H22N4O2/c1-2-24-18-10-8-15(9-11-20(25)23-26)12-17(18)22-19(24)14-21-13-16-6-4-3-5-7-16/h3-12,21,26H,2,13-14H2,1H3,(H,23,25)/b11-9+
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n/an/a 230n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM667
PNG
(US10201527, Compound 62 | US8551988, 62)
Show SMILES COc1ccc(CNCc2nc3cc(\C=C\C(=O)NO)ccc3n2C)cc1
Show InChI InChI=1S/C20H22N4O3/c1-24-18-9-5-14(6-10-20(25)23-26)11-17(18)22-19(24)13-21-12-15-3-7-16(27-2)8-4-15/h3-11,21,26H,12-13H2,1-2H3,(H,23,25)/b10-6+
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n/an/a 234n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM103545
PNG
(US10201527, Compound 22 | US8551988, 22)
Show SMILES CC(C)Cc1nc2cc(\C=C\C(=O)NO)ccc2n1CCc1ccccn1
Show InChI InChI=1S/C21H24N4O2/c1-15(2)13-20-23-18-14-16(7-9-21(26)24-27)6-8-19(18)25(20)12-10-17-5-3-4-11-22-17/h3-9,11,14-15,27H,10,12-13H2,1-2H3,(H,24,26)/b9-7+
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n/an/a 234n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
To determine EC50 where acetylated histone 3 was induced by 50%, Colo205 cells was cultivated in 96 well plate at 1.5105 cells/well for 24 h. Colo20...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM338947
PNG
(US10201527, Compound 42)
Show SMILES ONC(=O)\C=C\c1ccc2n(CCc3ccccn3)cnc2c1
Show InChI InChI=1S/C17H16N4O2/c22-17(20-23)7-5-13-4-6-16-15(11-13)19-12-21(16)10-8-14-3-1-2-9-18-14/h1-7,9,11-12,23H,8,10H2,(H,20,22)/b7-5+
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n/an/a 237n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
To determine EC50 where acetylated histone 3 was induced by 50%, Colo205 cells was cultivated in 96 well plate at 1.5105 cells/well for 24 h. Colo20...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM50248261
PNG
(CHEMBL475145 | N-hydroxy-3-(1-(3-hydroxypropyl)-2-...)
Show SMILES CC(C)Cc1nc2cc(\C=C\C(=O)NO)ccc2n1CCCO
Show InChI InChI=1S/C17H23N3O3/c1-12(2)10-16-18-14-11-13(5-7-17(22)19-23)4-6-15(14)20(16)8-3-9-21/h4-7,11-12,21,23H,3,8-10H2,1-2H3,(H,19,22)/b7-5+
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n/an/a 238n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
To determine EC50 where acetylated histone 3 was induced by 50%, Colo205 cells was cultivated in 96 well plate at 1.5105 cells/well for 24 h. Colo20...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM50248474
PNG
(CHEMBL491490 | N-hydroxy-3-(1-(3-morpholinopropyl)...)
Show SMILES ONC(=O)\C=C\c1ccc2n(CCCN3CCOCC3)c(CCc3ccccc3)nc2c1
Show InChI InChI=1S/C25H30N4O3/c30-25(27-31)12-9-21-7-10-23-22(19-21)26-24(11-8-20-5-2-1-3-6-20)29(23)14-4-13-28-15-17-32-18-16-28/h1-3,5-7,9-10,12,19,31H,4,8,11,13-18H2,(H,27,30)/b12-9+
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n/an/a 246n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM103534
PNG
(CHEMBL474152 | US10201527, Compound 40 | US8551988...)
Show SMILES OCCCn1c(CCc2ccccc2)nc2cc(\C=C\C(=O)NO)ccc12
Show InChI InChI=1S/C21H23N3O3/c25-14-4-13-24-19-10-7-17(9-12-21(26)23-27)15-18(19)22-20(24)11-8-16-5-2-1-3-6-16/h1-3,5-7,9-10,12,15,25,27H,4,8,11,13-14H2,(H,23,26)/b12-9+
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n/an/a 251n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
To determine EC50 where acetylated histone 3 was induced by 50%, Colo205 cells was cultivated in 96 well plate at 1.5105 cells/well for 24 h. Colo20...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM50248522
PNG
(CHEMBL489332 | N-hydroxy-3-(2-phenethyl-1-(2-(pipe...)
Show SMILES ONC(=O)\C=C\c1ccc2n(CCN3CCCCC3)c(CCc3ccccc3)nc2c1
Show InChI InChI=1S/C25H30N4O2/c30-25(27-31)14-11-21-9-12-23-22(19-21)26-24(13-10-20-7-3-1-4-8-20)29(23)18-17-28-15-5-2-6-16-28/h1,3-4,7-9,11-12,14,19,31H,2,5-6,10,13,15-18H2,(H,27,30)/b14-11+
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n/an/a 254n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
To determine EC50 where acetylated histone 3 was induced by 50%, Colo205 cells was cultivated in 96 well plate at 1.5105 cells/well for 24 h. Colo20...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM50248475
PNG
(3-(1-(2-(diethylamino)ethyl)-2-phenethyl-1H-benzo[...)
Show SMILES CCN(CC)CCn1c(CCc2ccccc2)nc2cc(\C=C\C(=O)NO)ccc12
Show InChI InChI=1S/C24H30N4O2/c1-3-27(4-2)16-17-28-22-13-10-20(12-15-24(29)26-30)18-21(22)25-23(28)14-11-19-8-6-5-7-9-19/h5-10,12-13,15,18,30H,3-4,11,14,16-17H2,1-2H3,(H,26,29)/b15-12+
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n/an/a 255n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
To determine EC50 where acetylated histone 3 was induced by 50%, Colo205 cells was cultivated in 96 well plate at 1.5105 cells/well for 24 h. Colo20...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM103536
PNG
(US10201527, Compound 6 | US8551988, 6)
Show SMILES COc1ccc(cc1)-c1nc2cc(\C=C\C(=O)NO)ccc2n1CC(O)CO
Show InChI InChI=1S/C20H21N3O5/c1-28-16-6-4-14(5-7-16)20-21-17-10-13(3-9-19(26)22-27)2-8-18(17)23(20)11-15(25)12-24/h2-10,15,24-25,27H,11-12H2,1H3,(H,22,26)/b9-3+
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n/an/a 262n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
To determine EC50 where acetylated histone 3 was induced by 50%, Colo205 cells was cultivated in 96 well plate at 1.5105 cells/well for 24 h. Colo20...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM50248429
PNG
(CHEMBL489709 | N-hydroxy-3-(1-(2-morpholinoethyl)-...)
Show SMILES ONC(=O)\C=C\c1ccc2n(CCN3CCOCC3)c(CCc3ccccc3)nc2c1
Show InChI InChI=1S/C24H28N4O3/c29-24(26-30)11-8-20-6-9-22-21(18-20)25-23(10-7-19-4-2-1-3-5-19)28(22)13-12-27-14-16-31-17-15-27/h1-6,8-9,11,18,30H,7,10,12-17H2,(H,26,29)/b11-8+
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n/an/a 268n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM103538
PNG
(US10201527, Compound 8 | US8551988, 8)
Show SMILES OCC(O)Cn1c(CCc2ccccc2)nc2cc(\C=C\C(=O)NO)ccc12
Show InChI InChI=1S/C21H23N3O4/c25-14-17(26)13-24-19-9-6-16(8-11-21(27)23-28)12-18(19)22-20(24)10-7-15-4-2-1-3-5-15/h1-6,8-9,11-12,17,25-26,28H,7,10,13-14H2,(H,23,27)/b11-8+
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n/an/a 286n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM103544
PNG
(US10201527, Compound 18 | US8551988, 18)
Show SMILES ONC(=O)\C=C\c1ccc2n(CCc3ccccn3)c(CCc3ccccc3)nc2c1
Show InChI InChI=1S/C25H24N4O2/c30-25(28-31)14-11-20-9-12-23-22(18-20)27-24(13-10-19-6-2-1-3-7-19)29(23)17-15-21-8-4-5-16-26-21/h1-9,11-12,14,16,18,31H,10,13,15,17H2,(H,28,30)/b14-11+
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n/an/a 290n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
To determine EC50 where acetylated histone 3 was induced by 50%, Colo205 cells was cultivated in 96 well plate at 1.5105 cells/well for 24 h. Colo20...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM338980
PNG
(US10201527, Compound 75)
Show SMILES CC(C)(C)Cn1c(CCc2ccccc2)nc2cc(\C=C\C(=O)NO)ccc12
Show InChI InChI=1S/C23H27N3O2/c1-23(2,3)16-26-20-12-9-18(11-14-22(27)25-28)15-19(20)24-21(26)13-10-17-7-5-4-6-8-17/h4-9,11-12,14-15,28H,10,13,16H2,1-3H3,(H,25,27)/b14-11+
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n/an/a 290n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM38236
PNG
(CHEMBL522269 | US10201527, Compound 48 | US8551988...)
Show SMILES Cn1c(CCc2ccccc2)nc2cc(\C=C\C(=O)NO)ccc12
Show InChI InChI=1S/C19H19N3O2/c1-22-17-10-7-15(9-12-19(23)21-24)13-16(17)20-18(22)11-8-14-5-3-2-4-6-14/h2-7,9-10,12-13,24H,8,11H2,1H3,(H,21,23)/b12-9+
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n/an/a 291n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
To determine EC50 where acetylated histone 3 was induced by 50%, Colo205 cells was cultivated in 96 well plate at 1.5105 cells/well for 24 h. Colo20...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM1103
PNG
(US10201527, Compound 68 | US8551988, 68)
Show SMILES CCn1c(CN(Cc2ccccc2)Cc2ccccc2)nc2cc(\C=C\C(=O)NO)ccc12
Show InChI InChI=1S/C27H28N4O2/c1-2-31-25-15-13-21(14-16-27(32)29-33)17-24(25)28-26(31)20-30(18-22-9-5-3-6-10-22)19-23-11-7-4-8-12-23/h3-17,33H,2,18-20H2,1H3,(H,29,32)/b16-14+
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n/an/a 294n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM103594
PNG
(US10201527, Compound 88 | US8551988, 88)
Show SMILES COc1cc(Cn2c(CCc3ccccc3)nc3cc(ccc23)C2CC2C(=O)NO)cc(OC)c1OC
Show InChI InChI=1S/C29H31N3O5/c1-35-25-13-19(14-26(36-2)28(25)37-3)17-32-24-11-10-20(21-16-22(21)29(33)31-34)15-23(24)30-27(32)12-9-18-7-5-4-6-8-18/h4-8,10-11,13-15,21-22,34H,9,12,16-17H2,1-3H3,(H,31,33)
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n/an/a 297n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM103548
PNG
(US10201527, Compound 28 | US8551988, 28)
Show SMILES ONC(=O)\C=C\c1ccc2n(CCc3cccnc3)c(COCc3ccccc3)nc2c1
Show InChI InChI=1S/C25H24N4O3/c30-25(28-31)11-9-19-8-10-23-22(15-19)27-24(18-32-17-21-5-2-1-3-6-21)29(23)14-12-20-7-4-13-26-16-20/h1-11,13,15-16,31H,12,14,17-18H2,(H,28,30)/b11-9+
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n/an/a 300n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
To determine EC50 where acetylated histone 3 was induced by 50%, Colo205 cells was cultivated in 96 well plate at 1.5105 cells/well for 24 h. Colo20...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM50248523
PNG
(CHEMBL489330 | N-hydroxy-3-(2-phenethyl-1-(3-(pyrr...)
Show SMILES ONC(=O)\C=C\c1ccc2n(CCCN3CCCC3)c(CCc3ccccc3)nc2c1
Show InChI InChI=1S/C25H30N4O2/c30-25(27-31)14-11-21-9-12-23-22(19-21)26-24(13-10-20-7-2-1-3-8-20)29(23)18-6-17-28-15-4-5-16-28/h1-3,7-9,11-12,14,19,31H,4-6,10,13,15-18H2,(H,27,30)/b14-11+
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n/an/a 304n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM50248432
PNG
(CHEMBL521909 | N-hydroxy-3-(1-(3-methoxypropyl)-2-...)
Show SMILES COCCCn1c(CCc2ccccc2)nc2cc(\C=C\C(=O)NO)ccc12
Show InChI InChI=1S/C22H25N3O3/c1-28-15-5-14-25-20-11-8-18(10-13-22(26)24-27)16-19(20)23-21(25)12-9-17-6-3-2-4-7-17/h2-4,6-8,10-11,13,16,27H,5,9,12,14-15H2,1H3,(H,24,26)/b13-10+
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n/an/a 313n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
To determine EC50 where acetylated histone 3 was induced by 50%, Colo205 cells was cultivated in 96 well plate at 1.5105 cells/well for 24 h. Colo20...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM103547
PNG
(US10201527, Compound 27 | US8551988, 27)
Show SMILES ONC(=O)\C=C\c1ccc2n(CCc3cccnc3)c(CCc3ccccc3)nc2c1
Show InChI InChI=1S/C25H24N4O2/c30-25(28-31)13-10-20-8-11-23-22(17-20)27-24(12-9-19-5-2-1-3-6-19)29(23)16-14-21-7-4-15-26-18-21/h1-8,10-11,13,15,17-18,31H,9,12,14,16H2,(H,28,30)/b13-10+
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n/an/a 329n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
To determine EC50 where acetylated histone 3 was induced by 50%, Colo205 cells was cultivated in 96 well plate at 1.5105 cells/well for 24 h. Colo20...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM103537
PNG
(US10201527, Compound 7 | US8551988, 7)
Show SMILES COc1cc(ccc1OCc1ccccc1)-c1nc2cc(\C=C\C(=O)NO)ccc2n1CC(O)CO
Show InChI InChI=1S/C27H27N3O6/c1-35-25-14-20(9-11-24(25)36-17-19-5-3-2-4-6-19)27-28-22-13-18(8-12-26(33)29-34)7-10-23(22)30(27)15-21(32)16-31/h2-14,21,31-32,34H,15-17H2,1H3,(H,29,33)/b12-8+
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n/an/a 336n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
To determine EC50 where acetylated histone 3 was induced by 50%, Colo205 cells was cultivated in 96 well plate at 1.5105 cells/well for 24 h. Colo20...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM103539
PNG
(US10201527, Compound 9 | US8551988, 9)
Show SMILES OCC(O)Cn1c(nc2cc(\C=C\C(=O)NO)ccc12)-c1ccccn1
Show InChI InChI=1S/C18H18N4O4/c23-11-13(24)10-22-16-6-4-12(5-7-17(25)21-26)9-15(16)20-18(22)14-3-1-2-8-19-14/h1-9,13,23-24,26H,10-11H2,(H,21,25)/b7-5+
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n/an/a 344n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
To determine EC50 where acetylated histone 3 was induced by 50%, Colo205 cells was cultivated in 96 well plate at 1.5105 cells/well for 24 h. Colo20...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM50248429
PNG
(CHEMBL489709 | N-hydroxy-3-(1-(2-morpholinoethyl)-...)
Show SMILES ONC(=O)\C=C\c1ccc2n(CCN3CCOCC3)c(CCc3ccccc3)nc2c1
Show InChI InChI=1S/C24H28N4O3/c29-24(26-30)11-8-20-6-9-22-21(18-20)25-23(10-7-19-4-2-1-3-5-19)28(22)13-12-27-14-16-31-17-15-27/h1-6,8-9,11,18,30H,7,10,12-17H2,(H,26,29)/b11-8+
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n/an/a 345n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
To determine EC50 where acetylated histone 3 was induced by 50%, Colo205 cells was cultivated in 96 well plate at 1.5105 cells/well for 24 h. Colo20...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM50248570
PNG
(3-(1-(3-(dimethylamino)-2,2-dimethylpropyl)-2-phen...)
Show SMILES CN(C)CC(C)(C)Cn1c(CCc2ccccc2)nc2cc(\C=C\C(=O)NO)ccc12
Show InChI InChI=1S/C25H32N4O2/c1-25(2,17-28(3)4)18-29-22-13-10-20(12-15-24(30)27-31)16-21(22)26-23(29)14-11-19-8-6-5-7-9-19/h5-10,12-13,15-16,31H,11,14,17-18H2,1-4H3,(H,27,30)/b15-12+
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n/an/a 353n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
To determine EC50 where acetylated histone 3 was induced by 50%, Colo205 cells was cultivated in 96 well plate at 1.5105 cells/well for 24 h. Colo20...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM50248375
PNG
(CHEMBL491688 | N-hydroxy-3-(2-phenethyl-1-(3,4,5-t...)
Show SMILES COc1cc(Cn2c(CCc3ccccc3)nc3cc(\C=C\C(=O)NO)ccc23)cc(OC)c1OC
Show InChI InChI=1S/C28H29N3O5/c1-34-24-16-21(17-25(35-2)28(24)36-3)18-31-23-12-9-20(11-14-27(32)30-33)15-22(23)29-26(31)13-10-19-7-5-4-6-8-19/h4-9,11-12,14-17,33H,10,13,18H2,1-3H3,(H,30,32)/b14-11+
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n/an/a 355n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
To determine EC50 where acetylated histone 3 was induced by 50%, Colo205 cells was cultivated in 96 well plate at 1.5105 cells/well for 24 h. Colo20...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM38236
PNG
(CHEMBL522269 | US10201527, Compound 48 | US8551988...)
Show SMILES Cn1c(CCc2ccccc2)nc2cc(\C=C\C(=O)NO)ccc12
Show InChI InChI=1S/C19H19N3O2/c1-22-17-10-7-15(9-12-19(23)21-24)13-16(17)20-18(22)11-8-14-5-3-2-4-6-14/h2-7,9-10,12-13,24H,8,11H2,1H3,(H,21,23)/b12-9+
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n/an/a 356n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM50247927
PNG
(CHEMBL489706 | N-hydroxy-3-(2-phenethyl-1-(pyridin...)
Show SMILES ONC(=O)\C=C\c1ccc2n(Cc3ccccn3)c(CCc3ccccc3)nc2c1
Show InChI InChI=1S/C24H22N4O2/c29-24(27-30)14-11-19-9-12-22-21(16-19)26-23(13-10-18-6-2-1-3-7-18)28(22)17-20-8-4-5-15-25-20/h1-9,11-12,14-16,30H,10,13,17H2,(H,27,29)/b14-11+
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n/an/a 366n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
To determine EC50 where acetylated histone 3 was induced by 50%, Colo205 cells was cultivated in 96 well plate at 1.5105 cells/well for 24 h. Colo20...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM1438
PNG
(US10201527, Compound 74 | US8551988, 74)
Show SMILES CCn1c(CCNCc2ccccc2)nc2cc(\C=C\C(=O)NO)ccc12
Show InChI InChI=1S/C21H24N4O2/c1-2-25-19-10-8-16(9-11-21(26)24-27)14-18(19)23-20(25)12-13-22-15-17-6-4-3-5-7-17/h3-11,14,22,27H,2,12-13,15H2,1H3,(H,24,26)/b11-9+
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n/an/a 371n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM103551
PNG
(US10201527, Compound 35 | US8551988, 35)
Show SMILES ONC(=O)\C=C\c1ccc2n(Cc3ccccc3)cnc2c1
Show InChI InChI=1S/C17H15N3O2/c21-17(19-22)9-7-13-6-8-16-15(10-13)18-12-20(16)11-14-4-2-1-3-5-14/h1-10,12,22H,11H2,(H,19,21)/b9-7+
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n/an/a 371n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM338964
PNG
(US10201527, Compound 59)
Show SMILES Cn1c(CCc2ccccc2)nc2ccc(\C=C\C(=O)NO)cc12
Show InChI InChI=1S/C19H19N3O2/c1-22-17-13-15(9-12-19(23)21-24)7-10-16(17)20-18(22)11-8-14-5-3-2-4-6-14/h2-7,9-10,12-13,24H,8,11H2,1H3,(H,21,23)/b12-9+
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n/an/a 382n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM103543
PNG
(US10201527, Compound 13 | US8551988, 13)
Show SMILES OCCCn1c(nc2cc(\C=C\C(=O)NO)ccc12)-c1ccccn1
Show InChI InChI=1S/C18H18N4O3/c23-11-3-10-22-16-7-5-13(6-8-17(24)21-25)12-15(16)20-18(22)14-4-1-2-9-19-14/h1-2,4-9,12,23,25H,3,10-11H2,(H,21,24)/b8-6+
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n/an/a 385n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM103592
PNG
(US10201527, Compound 86 | US8551988, 86)
Show SMILES CN(C)CC(C)(C)Cn1c(CCc2cccnc2)nc2cc(\C=C\C(=O)NO)ccc12
Show InChI InChI=1S/C24H31N5O2/c1-24(2,16-28(3)4)17-29-21-10-7-18(9-12-23(30)27-31)14-20(21)26-22(29)11-8-19-6-5-13-25-15-19/h5-7,9-10,12-15,31H,8,11,16-17H2,1-4H3,(H,27,30)/b12-9+
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n/an/a 400n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM103535
PNG
(US10201527, Compound 5 | US8551988, 5)
Show SMILES COc1ccc(cc1)-c1nc2cc(\C=C\C(=O)NO)ccc2n1CCO
Show InChI InChI=1S/C19H19N3O4/c1-26-15-6-4-14(5-7-15)19-20-16-12-13(3-9-18(24)21-25)2-8-17(16)22(19)10-11-23/h2-9,12,23,25H,10-11H2,1H3,(H,21,24)/b9-3+
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n/an/a 401n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
To determine EC50 where acetylated histone 3 was induced by 50%, Colo205 cells was cultivated in 96 well plate at 1.5105 cells/well for 24 h. Colo20...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM50248312
PNG
(CHEMBL474151 | N-hydroxy-3-(1-(3-hydroxypropyl)-2-...)
Show SMILES CCCCCCCCc1nc2cc(\C=C\C(=O)NO)ccc2n1CCCO
Show InChI InChI=1S/C21H31N3O3/c1-2-3-4-5-6-7-9-20-22-18-16-17(11-13-21(26)23-27)10-12-19(18)24(20)14-8-15-25/h10-13,16,25,27H,2-9,14-15H2,1H3,(H,23,26)/b13-11+
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n/an/a 402n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
To determine EC50 where acetylated histone 3 was induced by 50%, Colo205 cells was cultivated in 96 well plate at 1.5105 cells/well for 24 h. Colo20...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM103551
PNG
(US10201527, Compound 35 | US8551988, 35)
Show SMILES ONC(=O)\C=C\c1ccc2n(Cc3ccccc3)cnc2c1
Show InChI InChI=1S/C17H15N3O2/c21-17(19-22)9-7-13-6-8-16-15(10-13)18-12-20(16)11-14-4-2-1-3-5-14/h1-10,12,22H,11H2,(H,19,21)/b9-7+
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n/an/a 412n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
To determine EC50 where acetylated histone 3 was induced by 50%, Colo205 cells was cultivated in 96 well plate at 1.5105 cells/well for 24 h. Colo20...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM103544
PNG
(US10201527, Compound 18 | US8551988, 18)
Show SMILES ONC(=O)\C=C\c1ccc2n(CCc3ccccn3)c(CCc3ccccc3)nc2c1
Show InChI InChI=1S/C25H24N4O2/c30-25(28-31)14-11-20-9-12-23-22(18-20)27-24(13-10-19-6-2-1-3-7-19)29(23)17-15-21-8-4-5-16-26-21/h1-9,11-12,14,16,18,31H,10,13,15,17H2,(H,28,30)/b14-11+
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n/an/a 438n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM103534
PNG
(CHEMBL474152 | US10201527, Compound 40 | US8551988...)
Show SMILES OCCCn1c(CCc2ccccc2)nc2cc(\C=C\C(=O)NO)ccc12
Show InChI InChI=1S/C21H23N3O3/c25-14-4-13-24-19-10-7-17(9-12-21(26)23-27)15-18(19)22-20(24)11-8-16-5-2-1-3-6-16/h1-3,5-7,9-10,12,15,25,27H,4,8,11,13-14H2,(H,23,26)/b12-9+
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n/an/a 441n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
To determine EC50 where acetylated histone 3 was induced by 50%, Colo205 cells was cultivated in 96 well plate at 1.5105 cells/well for 24 h. Colo20...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM38237
PNG
(CHEMBL491687 | US10201527, Compound 33 | US8551988...)
Show SMILES ONC(=O)\C=C\c1ccc2n(Cc3ccccc3)c(CCc3ccccc3)nc2c1
Show InChI InChI=1S/C25H23N3O2/c29-25(27-30)16-13-20-11-14-23-22(17-20)26-24(15-12-19-7-3-1-4-8-19)28(23)18-21-9-5-2-6-10-21/h1-11,13-14,16-17,30H,12,15,18H2,(H,27,29)/b16-13+
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n/an/a 449n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM103538
PNG
(US10201527, Compound 8 | US8551988, 8)
Show SMILES OCC(O)Cn1c(CCc2ccccc2)nc2cc(\C=C\C(=O)NO)ccc12
Show InChI InChI=1S/C21H23N3O4/c25-14-17(26)13-24-19-9-6-16(8-11-21(27)23-28)12-18(19)22-20(24)10-7-15-4-2-1-3-5-15/h1-6,8-9,11-12,17,25-26,28H,7,10,13-14H2,(H,23,27)/b11-8+
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n/an/a 454n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
To determine EC50 where acetylated histone 3 was induced by 50%, Colo205 cells was cultivated in 96 well plate at 1.5105 cells/well for 24 h. Colo20...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM338947
PNG
(US10201527, Compound 42)
Show SMILES ONC(=O)\C=C\c1ccc2n(CCc3ccccn3)cnc2c1
Show InChI InChI=1S/C17H16N4O2/c22-17(20-23)7-5-13-4-6-16-15(11-13)19-12-21(16)10-8-14-3-1-2-9-18-14/h1-7,9,11-12,23H,8,10H2,(H,20,22)/b7-5+
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n/an/a 479n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM338992
PNG
(US10201527, Compound 87)
Show SMILES ONC(=O)\C=C\c1ccc2[nH]c(CCc3cccnc3)nc2c1
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n/an/a 517n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM50248312
PNG
(CHEMBL474151 | N-hydroxy-3-(1-(3-hydroxypropyl)-2-...)
Show SMILES CCCCCCCCc1nc2cc(\C=C\C(=O)NO)ccc2n1CCCO
Show InChI InChI=1S/C21H31N3O3/c1-2-3-4-5-6-7-9-20-22-18-16-17(11-13-21(26)23-27)10-12-19(18)24(20)14-8-15-25/h10-13,16,25,27H,2-9,14-15H2,1H3,(H,23,26)/b13-11+
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n/an/a 529n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM50248259
PNG
(CHEMBL474546 | N-hydroxy-3-(1-(3-hydroxypropyl)-2-...)
Show SMILES OCCCn1c(nc2cc(\C=C\C(=O)NO)ccc12)-c1ccsc1
Show InChI InChI=1S/C17H17N3O3S/c21-8-1-7-20-15-4-2-12(3-5-16(22)19-23)10-14(15)18-17(20)13-6-9-24-11-13/h2-6,9-11,21,23H,1,7-8H2,(H,19,22)/b5-3+
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n/an/a 537n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
To determine EC50 where acetylated histone 3 was induced by 50%, Colo205 cells was cultivated in 96 well plate at 1.5105 cells/well for 24 h. Colo20...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM1447
PNG
(US10201527, Compound 73 | US8551988, 73)
Show SMILES CCn1c(CCNC(=O)COc2ccccc2)nc2cc(\C=C\C(=O)NO)ccc12
Show InChI InChI=1S/C22H24N4O4/c1-2-26-19-10-8-16(9-11-21(27)25-29)14-18(19)24-20(26)12-13-23-22(28)15-30-17-6-4-3-5-7-17/h3-11,14,29H,2,12-13,15H2,1H3,(H,23,28)(H,25,27)/b11-9+
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n/an/a 560n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM1456
PNG
(US10201527, Compound 77 | US8551988, 77)
Show SMILES OCCn1c(CCc2ccccc2)nc2cc(\C=C\C(=O)NO)ccc12
Show InChI InChI=1S/C20H21N3O3/c24-13-12-23-18-9-6-16(8-11-20(25)22-26)14-17(18)21-19(23)10-7-15-4-2-1-3-5-15/h1-6,8-9,11,14,24,26H,7,10,12-13H2,(H,22,25)/b11-8+
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n/an/a 570n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM103546
PNG
(US10201527, Compound 25 | US8551988, 25)
Show SMILES CC(C)Cc1nc2cc(\C=C\C(=O)NO)ccc2n1CCc1ccccc1
Show InChI InChI=1S/C22H25N3O2/c1-16(2)14-21-23-19-15-18(9-11-22(26)24-27)8-10-20(19)25(21)13-12-17-6-4-3-5-7-17/h3-11,15-16,27H,12-14H2,1-2H3,(H,24,26)/b11-9+
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n/an/a 601n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
To determine EC50 where acetylated histone 3 was induced by 50%, Colo205 cells was cultivated in 96 well plate at 1.5105 cells/well for 24 h. Colo20...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM50248473
PNG
(CHEMBL523646 | N-hydroxy-3-(1-(3-(2-oxopyrrolidin-...)
Show SMILES ONC(=O)\C=C\c1ccc2n(CCCN3CCCC3=O)c(CCc3ccccc3)nc2c1
Show InChI InChI=1S/C25H28N4O3/c30-24(27-32)14-11-20-9-12-22-21(18-20)26-23(13-10-19-6-2-1-3-7-19)29(22)17-5-16-28-15-4-8-25(28)31/h1-3,6-7,9,11-12,14,18,32H,4-5,8,10,13,15-17H2,(H,27,30)/b14-11+
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n/an/a 724n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
To determine EC50 where acetylated histone 3 was induced by 50%, Colo205 cells was cultivated in 96 well plate at 1.5105 cells/well for 24 h. Colo20...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM38233
PNG
(US10201527, Compound 4 | US8551988, 4)
Show SMILES COc1cc(ccc1OCc1ccccc1)-c1nc2cc(\C=C\C(=O)NO)ccc2n1CCCO
Show InChI InChI=1S/C27H27N3O5/c1-34-25-17-21(10-12-24(25)35-18-20-6-3-2-4-7-20)27-28-22-16-19(9-13-26(32)29-33)8-11-23(22)30(27)14-5-15-31/h2-4,6-13,16-17,31,33H,5,14-15,18H2,1H3,(H,29,32)/b13-9+
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n/an/a 790n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
To determine EC50 where acetylated histone 3 was induced by 50%, Colo205 cells was cultivated in 96 well plate at 1.5105 cells/well for 24 h. Colo20...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM103550
PNG
(US10201527, Compound 34 | US8551988, 34)
Show SMILES CC(C)Cc1nc2cc(\C=C\C(=O)NO)ccc2n1Cc1ccccc1
Show InChI InChI=1S/C21H23N3O2/c1-15(2)12-20-22-18-13-16(9-11-21(25)23-26)8-10-19(18)24(20)14-17-6-4-3-5-7-17/h3-11,13,15,26H,12,14H2,1-2H3,(H,23,25)/b11-9+
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n/an/a 846n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
To determine EC50 where acetylated histone 3 was induced by 50%, Colo205 cells was cultivated in 96 well plate at 1.5105 cells/well for 24 h. Colo20...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM103541
PNG
(US10201527, Compound 11 | US8551988, 11)
Show SMILES OCCCn1c(nc2cc(\C=C\C(=O)NO)ccc12)-c1ccncc1
Show InChI InChI=1S/C18H18N4O3/c23-11-1-10-22-16-4-2-13(3-5-17(24)21-25)12-15(16)20-18(22)14-6-8-19-9-7-14/h2-9,12,23,25H,1,10-11H2,(H,21,24)/b5-3+
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n/an/a 846n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM50248430
PNG
(3-(1,2-diphenethyl-1H-benzo[d]imidazol-5-yl)-N-hyd...)
Show SMILES ONC(=O)\C=C\c1ccc2n(CCc3ccccc3)c(CCc3ccccc3)nc2c1
Show InChI InChI=1S/C26H25N3O2/c30-26(28-31)16-13-22-11-14-24-23(19-22)27-25(15-12-20-7-3-1-4-8-20)29(24)18-17-21-9-5-2-6-10-21/h1-11,13-14,16,19,31H,12,15,17-18H2,(H,28,30)/b16-13+
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n/an/a 876n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM103540
PNG
(US10201527, Compound 10 | US8551988, 10)
Show SMILES OCCn1c(nc2cc(\C=C\C(=O)NO)ccc12)-c1ccncc1
Show InChI InChI=1S/C17H16N4O3/c22-10-9-21-15-3-1-12(2-4-16(23)20-24)11-14(15)19-17(21)13-5-7-18-8-6-13/h1-8,11,22,24H,9-10H2,(H,20,23)/b4-2+
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n/an/a 883n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
To determine EC50 where acetylated histone 3 was induced by 50%, Colo205 cells was cultivated in 96 well plate at 1.5105 cells/well for 24 h. Colo20...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM338956
PNG
(US10201527, Compound 51)
Show SMILES ONC(=O)\C=C\c1ccc2[nH]cnc2c1
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n/an/a 896n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM103552
PNG
(US10201527, Compound 37 | US8551988, 37)
Show SMILES CCCn1cnc2cc(\C=C\C(=O)NO)ccc12
Show InChI InChI=1S/C13H15N3O2/c1-2-7-16-9-14-11-8-10(3-5-12(11)16)4-6-13(17)15-18/h3-6,8-9,18H,2,7H2,1H3,(H,15,17)/b6-4+
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n/an/a 897n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM338975
PNG
(US10201527, Compound 70)
Show SMILES CCn1c(CCNC(=O)Cc2ccccc2)nc2cc(\C=C\C(=O)NO)ccc12
Show InChI InChI=1S/C22H24N4O3/c1-2-26-19-10-8-17(9-11-21(27)25-29)14-18(19)24-20(26)12-13-23-22(28)15-16-6-4-3-5-7-16/h3-11,14,29H,2,12-13,15H2,1H3,(H,23,28)(H,25,27)/b11-9+
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n/an/a 923n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM246
PNG
(US10201527, Compound 43 | US8551988, 43)
Show SMILES CCn1c(C)nc2cc(\C=C\C(=O)NO)ccc12
Show InChI InChI=1S/C13H15N3O2/c1-3-16-9(2)14-11-8-10(4-6-12(11)16)5-7-13(17)15-18/h4-8,18H,3H2,1-2H3,(H,15,17)/b7-5+
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n/an/a 947n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM50248430
PNG
(3-(1,2-diphenethyl-1H-benzo[d]imidazol-5-yl)-N-hyd...)
Show SMILES ONC(=O)\C=C\c1ccc2n(CCc3ccccc3)c(CCc3ccccc3)nc2c1
Show InChI InChI=1S/C26H25N3O2/c30-26(28-31)16-13-22-11-14-24-23(19-22)27-25(15-12-20-7-3-1-4-8-20)29(24)18-17-21-9-5-2-6-10-21/h1-11,13-14,16,19,31H,12,15,17-18H2,(H,28,30)/b16-13+
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US Patent
n/an/a 1.01E+3n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
To determine EC50 where acetylated histone 3 was induced by 50%, Colo205 cells was cultivated in 96 well plate at 1.5105 cells/well for 24 h. Colo20...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM1576
PNG
(US10201527, Compound 76 | US8551988, 76)
Show SMILES ONC(=O)\C=C\c1ccc2n(C3CCN(Cc4ccccc4)CC3)c(CCc3ccccc3)nc2c1
Show InChI InChI=1S/C30H32N4O2/c35-30(32-36)16-13-24-11-14-28-27(21-24)31-29(15-12-23-7-3-1-4-8-23)34(28)26-17-19-33(20-18-26)22-25-9-5-2-6-10-25/h1-11,13-14,16,21,26,36H,12,15,17-20,22H2,(H,32,35)/b16-13+
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n/an/a 1.03E+3n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM50248474
PNG
(CHEMBL491490 | N-hydroxy-3-(1-(3-morpholinopropyl)...)
Show SMILES ONC(=O)\C=C\c1ccc2n(CCCN3CCOCC3)c(CCc3ccccc3)nc2c1
Show InChI InChI=1S/C25H30N4O3/c30-25(27-31)12-9-21-7-10-23-22(19-21)26-24(11-8-20-5-2-1-3-6-20)29(23)14-4-13-28-15-17-32-18-16-28/h1-3,5-7,9-10,12,19,31H,4,8,11,13-18H2,(H,27,30)/b12-9+
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n/an/a 1.09E+3n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
To determine EC50 where acetylated histone 3 was induced by 50%, Colo205 cells was cultivated in 96 well plate at 1.5105 cells/well for 24 h. Colo20...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM50248257
PNG
((E)-N-hydroxy-3-(1-(3-hydroxypropyl)-1H-benzo[d]im...)
Show SMILES OCCCn1cnc2cc(\C=C\C(=O)NO)ccc12
Show InChI InChI=1S/C13H15N3O3/c17-7-1-6-16-9-14-11-8-10(2-4-12(11)16)3-5-13(18)15-19/h2-5,8-9,17,19H,1,6-7H2,(H,15,18)/b5-3+
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n/an/a 1.09E+3n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM50247926
PNG
(3-(1-benzyl-2-phenethyl-1H-benzo[d]imidazol-6-yl)-...)
Show SMILES ONC(=O)\C=C\c1ccc2nc(CCc3ccccc3)n(Cc3ccccc3)c2c1
Show InChI InChI=1S/C25H23N3O2/c29-25(27-30)16-13-20-11-14-22-23(17-20)28(18-21-9-5-2-6-10-21)24(26-22)15-12-19-7-3-1-4-8-19/h1-11,13-14,16-17,30H,12,15,18H2,(H,27,29)/b16-13+
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US Patent
n/an/a 1.14E+3n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM338944
PNG
(US10201527, Compound 39)
Show SMILES CCn1cnc2cc(\C=C\C(=O)NO)ccc12
Show InChI InChI=1S/C12H13N3O2/c1-2-15-8-13-10-7-9(3-5-11(10)15)4-6-12(16)14-17/h3-8,17H,2H2,1H3,(H,14,16)/b6-4+
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n/an/a 1.22E+3n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM103586
PNG
(US10201527, Compound 79 | US8551988, 79)
Show SMILES ONC(=O)\C=C\c1ccc2n(CC=C)c(CCc3ccccc3)nc2c1
Show InChI InChI=1S/C21H21N3O2/c1-2-14-24-19-11-8-17(10-13-21(25)23-26)15-18(19)22-20(24)12-9-16-6-4-3-5-7-16/h2-8,10-11,13,15,26H,1,9,12,14H2,(H,23,25)/b13-10+
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n/an/a 1.26E+3n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM103546
PNG
(US10201527, Compound 25 | US8551988, 25)
Show SMILES CC(C)Cc1nc2cc(\C=C\C(=O)NO)ccc2n1CCc1ccccc1
Show InChI InChI=1S/C22H25N3O2/c1-16(2)14-21-23-19-15-18(9-11-22(26)24-27)8-10-20(19)25(21)13-12-17-6-4-3-5-7-17/h3-11,15-16,27H,12-14H2,1-2H3,(H,24,26)/b11-9+
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n/an/a 1.32E+3n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM103545
PNG
(US10201527, Compound 22 | US8551988, 22)
Show SMILES CC(C)Cc1nc2cc(\C=C\C(=O)NO)ccc2n1CCc1ccccn1
Show InChI InChI=1S/C21H24N4O2/c1-15(2)13-20-23-18-14-16(7-9-21(26)24-27)6-8-19(18)25(20)12-10-17-5-3-4-11-22-17/h3-9,11,14-15,27H,10,12-13H2,1-2H3,(H,24,26)/b9-7+
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n/an/a 1.33E+3n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM103539
PNG
(US10201527, Compound 9 | US8551988, 9)
Show SMILES OCC(O)Cn1c(nc2cc(\C=C\C(=O)NO)ccc12)-c1ccccn1
Show InChI InChI=1S/C18H18N4O4/c23-11-13(24)10-22-16-6-4-12(5-7-17(25)21-26)9-15(16)20-18(22)14-3-1-2-8-19-14/h1-9,13,23-24,26H,10-11H2,(H,21,25)/b7-5+
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n/an/a 1.34E+3n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM38233
PNG
(US10201527, Compound 4 | US8551988, 4)
Show SMILES COc1cc(ccc1OCc1ccccc1)-c1nc2cc(\C=C\C(=O)NO)ccc2n1CCCO
Show InChI InChI=1S/C27H27N3O5/c1-34-25-17-21(10-12-24(25)35-18-20-6-3-2-4-7-20)27-28-22-16-19(9-13-26(32)29-33)8-11-23(22)30(27)14-5-15-31/h2-4,6-13,16-17,31,33H,5,14-15,18H2,1H3,(H,29,32)/b13-9+
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n/an/a 1.34E+3n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM103533
PNG
(US10201527, Compound 3 | US8551988, 3)
Show SMILES COc1cc(ccc1OCc1ccccc1)-c1nc2cc(\C=C\C(=O)NO)ccc2n1C
Show InChI InChI=1S/C25H23N3O4/c1-28-21-11-8-17(9-13-24(29)27-30)14-20(21)26-25(28)19-10-12-22(23(15-19)31-2)32-16-18-6-4-3-5-7-18/h3-15,30H,16H2,1-2H3,(H,27,29)/b13-9+
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n/an/a 1.37E+3n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM103536
PNG
(US10201527, Compound 6 | US8551988, 6)
Show SMILES COc1ccc(cc1)-c1nc2cc(\C=C\C(=O)NO)ccc2n1CC(O)CO
Show InChI InChI=1S/C20H21N3O5/c1-28-16-6-4-14(5-7-16)20-21-17-10-13(3-9-19(26)22-27)2-8-18(17)23(20)11-15(25)12-24/h2-10,15,24-25,27H,11-12H2,1H3,(H,22,26)/b9-3+
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n/an/a 1.38E+3n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM38234
PNG
(US10201527, Compound 49 | US8551988, 39)
Show SMILES Cn1cnc2cc(\C=C\C(=O)NO)ccc12
Show InChI InChI=1S/C11H11N3O2/c1-14-7-12-9-6-8(2-4-10(9)14)3-5-11(15)13-16/h2-7,16H,1H3,(H,13,15)/b5-3+
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n/an/a 1.40E+3n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM38237
PNG
(CHEMBL491687 | US10201527, Compound 33 | US8551988...)
Show SMILES ONC(=O)\C=C\c1ccc2n(Cc3ccccc3)c(CCc3ccccc3)nc2c1
Show InChI InChI=1S/C25H23N3O2/c29-25(27-30)16-13-20-11-14-23-22(17-20)26-24(15-12-19-7-3-1-4-8-19)28(23)18-21-9-5-2-6-10-21/h1-11,13-14,16-17,30H,12,15,18H2,(H,27,29)/b16-13+
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n/an/a 1.45E+3n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
To determine EC50 where acetylated histone 3 was induced by 50%, Colo205 cells was cultivated in 96 well plate at 1.5105 cells/well for 24 h. Colo20...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM103550
PNG
(US10201527, Compound 34 | US8551988, 34)
Show SMILES CC(C)Cc1nc2cc(\C=C\C(=O)NO)ccc2n1Cc1ccccc1
Show InChI InChI=1S/C21H23N3O2/c1-15(2)12-20-22-18-13-16(9-11-21(25)23-26)8-10-19(18)24(20)14-17-6-4-3-5-7-17/h3-11,13,15,26H,12,14H2,1-2H3,(H,23,25)/b11-9+
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n/an/a 1.46E+3n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM103537
PNG
(US10201527, Compound 7 | US8551988, 7)
Show SMILES COc1cc(ccc1OCc1ccccc1)-c1nc2cc(\C=C\C(=O)NO)ccc2n1CC(O)CO
Show InChI InChI=1S/C27H27N3O6/c1-35-25-14-20(9-11-24(25)36-17-19-5-3-2-4-6-19)27-28-22-13-18(8-12-26(33)29-34)7-10-23(22)30(27)15-21(32)16-31/h2-14,21,31-32,34H,15-17H2,1H3,(H,29,33)/b12-8+
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n/an/a 1.52E+3n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM103588
PNG
(US10201527, Compound 81 | US8551988, 81)
Show SMILES CN1CCN(CCCn2c(CCc3ccccc3)nc3cc(\C=C\C(=O)NO)ccc23)CC1
Show InChI InChI=1S/C26H33N5O2/c1-29-16-18-30(19-17-29)14-5-15-31-24-11-8-22(10-13-26(32)28-33)20-23(24)27-25(31)12-9-21-6-3-2-4-7-21/h2-4,6-8,10-11,13,20,33H,5,9,12,14-19H2,1H3,(H,28,32)/b13-10+
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n/an/a 1.60E+3n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM50248260
PNG
(CHEMBL474547 | N-hydroxy-3-(1-(3-hydroxypropyl)-2-...)
Show SMILES CC(C)c1nc2cc(\C=C\C(=O)NO)ccc2n1CCCO
Show InChI InChI=1S/C16H21N3O3/c1-11(2)16-17-13-10-12(5-7-15(21)18-22)4-6-14(13)19(16)8-3-9-20/h4-7,10-11,20,22H,3,8-9H2,1-2H3,(H,18,21)/b7-5+
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n/an/a 1.67E+3n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM103587
PNG
(US10201527, Compound 80 | US8551988, 80)
Show SMILES CC(C)OCCCn1c(CCc2ccccc2)nc2cc(\C=C\C(=O)NO)ccc12
Show InChI InChI=1S/C24H29N3O3/c1-18(2)30-16-6-15-27-22-12-9-20(11-14-24(28)26-29)17-21(22)25-23(27)13-10-19-7-4-3-5-8-19/h3-5,7-9,11-12,14,17-18,29H,6,10,13,15-16H2,1-2H3,(H,26,28)/b14-11+
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n/an/a 1.69E+3n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM103533
PNG
(US10201527, Compound 3 | US8551988, 3)
Show SMILES COc1cc(ccc1OCc1ccccc1)-c1nc2cc(\C=C\C(=O)NO)ccc2n1C
Show InChI InChI=1S/C25H23N3O4/c1-28-21-11-8-17(9-13-24(29)27-30)14-20(21)26-25(28)19-10-12-22(23(15-19)31-2)32-16-18-6-4-3-5-7-18/h3-15,30H,16H2,1-2H3,(H,27,29)/b13-9+
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n/an/a 1.71E+3n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
To determine EC50 where acetylated histone 3 was induced by 50%, Colo205 cells was cultivated in 96 well plate at 1.5105 cells/well for 24 h. Colo20...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM338958
PNG
(US10201527, Compound 53)
Show SMILES Cc1nc2cc(\C=C\C(=O)NO)ccc2n1C
Show InChI InChI=1S/C12H13N3O2/c1-8-13-10-7-9(4-6-12(16)14-17)3-5-11(10)15(8)2/h3-7,17H,1-2H3,(H,14,16)/b6-4+
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n/an/a 1.85E+3n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM50248377
PNG
(3-(5-(3-(hydroxyamino)-3-oxoprop-1-enyl)-2-pheneth...)
Show SMILES ONC(=O)\C=C\c1ccc2n(CCC(O)=O)c(CCc3ccccc3)nc2c1
Show InChI InChI=1S/C21H21N3O4/c25-20(23-28)11-8-16-6-9-18-17(14-16)22-19(24(18)13-12-21(26)27)10-7-15-4-2-1-3-5-15/h1-6,8-9,11,14,28H,7,10,12-13H2,(H,23,25)(H,26,27)/b11-8+
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n/an/a 1.89E+3n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
To determine EC50 where acetylated histone 3 was induced by 50%, Colo205 cells was cultivated in 96 well plate at 1.5105 cells/well for 24 h. Colo20...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM50248259
PNG
(CHEMBL474546 | N-hydroxy-3-(1-(3-hydroxypropyl)-2-...)
Show SMILES OCCCn1c(nc2cc(\C=C\C(=O)NO)ccc12)-c1ccsc1
Show InChI InChI=1S/C17H17N3O3S/c21-8-1-7-20-15-4-2-12(3-5-16(22)19-23)10-14(15)18-17(20)13-6-9-24-11-13/h2-6,9-11,21,23H,1,7-8H2,(H,19,22)/b5-3+
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n/an/a 1.91E+3n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM50248377
PNG
(3-(5-(3-(hydroxyamino)-3-oxoprop-1-enyl)-2-pheneth...)
Show SMILES ONC(=O)\C=C\c1ccc2n(CCC(O)=O)c(CCc3ccccc3)nc2c1
Show InChI InChI=1S/C21H21N3O4/c25-20(23-28)11-8-16-6-9-18-17(14-16)22-19(24(18)13-12-21(26)27)10-7-15-4-2-1-3-5-15/h1-6,8-9,11,14,28H,7,10,12-13H2,(H,23,25)(H,26,27)/b11-8+
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n/an/a 2.21E+3n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM103540
PNG
(US10201527, Compound 10 | US8551988, 10)
Show SMILES OCCn1c(nc2cc(\C=C\C(=O)NO)ccc12)-c1ccncc1
Show InChI InChI=1S/C17H16N4O3/c22-10-9-21-15-3-1-12(2-4-16(23)20-24)11-14(15)19-17(21)13-5-7-18-8-6-13/h1-8,11,22,24H,9-10H2,(H,20,23)/b4-2+
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n/an/a 2.66E+3n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM50248258
PNG
(3-(2-cyclohexyl-1-(3-hydroxypropyl)-1H-benzo[d]imi...)
Show SMILES OCCCn1c(nc2cc(\C=C\C(=O)NO)ccc12)C1CCCCC1
Show InChI InChI=1S/C19H25N3O3/c23-12-4-11-22-17-9-7-14(8-10-18(24)21-25)13-16(17)20-19(22)15-5-2-1-3-6-15/h7-10,13,15,23,25H,1-6,11-12H2,(H,21,24)/b10-8+
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n/an/a 3.24E+3n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM103534
PNG
(CHEMBL474152 | US10201527, Compound 40 | US8551988...)
Show SMILES OCCCn1c(CCc2ccccc2)nc2cc(\C=C\C(=O)NO)ccc12
Show InChI InChI=1S/C21H23N3O3/c25-14-4-13-24-19-10-7-17(9-12-21(26)23-27)15-18(19)22-20(24)11-8-16-5-2-1-3-6-16/h1-3,5-7,9-10,12,15,25,27H,4,8,11,13-14H2,(H,23,26)/b12-9+
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n/an/a 3.30E+3n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM103535
PNG
(US10201527, Compound 5 | US8551988, 5)
Show SMILES COc1ccc(cc1)-c1nc2cc(\C=C\C(=O)NO)ccc2n1CCO
Show InChI InChI=1S/C19H19N3O4/c1-26-15-6-4-14(5-7-15)19-20-16-12-13(3-9-18(24)21-25)2-8-17(16)22(19)10-11-23/h2-9,12,23,25H,10-11H2,1H3,(H,21,24)/b9-3+
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n/an/a 4.32E+3n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM50248571
PNG
(CHEMBL461173 | N-hydroxy-3-(1-(3-hydroxypropyl)-2-...)
Show SMILES CC(C)Cc1nc2cc(CCC(=O)NO)ccc2n1CCCO
Show InChI InChI=1S/C17H25N3O3/c1-12(2)10-16-18-14-11-13(5-7-17(22)19-23)4-6-15(14)20(16)8-3-9-21/h4,6,11-12,21,23H,3,5,7-10H2,1-2H3,(H,19,22)
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n/an/a 3.40E+4n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
To determine EC50 where acetylated histone 3 was induced by 50%, Colo205 cells was cultivated in 96 well plate at 1.5105 cells/well for 24 h. Colo20...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM50248571
PNG
(CHEMBL461173 | N-hydroxy-3-(1-(3-hydroxypropyl)-2-...)
Show SMILES CC(C)Cc1nc2cc(CCC(=O)NO)ccc2n1CCCO
Show InChI InChI=1S/C17H25N3O3/c1-12(2)10-16-18-14-11-13(5-7-17(22)19-23)4-6-15(14)20(16)8-3-9-21/h4,6,11-12,21,23H,3,5,7-10H2,1-2H3,(H,19,22)
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n/an/a 4.91E+4n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM1662
PNG
(US10201527, Compound 78 | US8551988, 78)
Show SMILES OCCCCCn1c(CCc2ccccc2)nc2cc(\C=C\C(=O)NO)ccc12
Show InChI InChI=1S/C23H27N3O3/c27-16-6-2-5-15-26-21-12-9-19(11-14-23(28)25-29)17-20(21)24-22(26)13-10-18-7-3-1-4-8-18/h1,3-4,7-9,11-12,14,17,27,29H,2,5-6,10,13,15-16H2,(H,25,28)/b14-11+
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n/an/a>1.00E+5n/an/an/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone H3.1


(Homo sapiens (Human))
BDBM50248570
PNG
(3-(1-(3-(dimethylamino)-2,2-dimethylpropyl)-2-phen...)
Show SMILES CN(C)CC(C)(C)Cn1c(CCc2ccccc2)nc2cc(\C=C\C(=O)NO)ccc12
Show InChI InChI=1S/C25H32N4O2/c1-25(2,17-28(3)4)18-29-22-13-10-20(12-15-24(30)27-31)16-21(22)26-23(29)14-11-19-8-6-5-7-9-19/h5-10,12-13,15-16,31H,11,14,17-18H2,1-4H3,(H,27,30)/b15-12+
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n/an/an/an/a 1.10E+3n/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
To determine EC50 where acetylated histone 3 was induced by 50%, Colo205 cells was cultivated in 96 well plate at 1.5105 cells/well for 24 h. Colo20...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone H3.1


(Homo sapiens (Human))
BDBM50248375
PNG
(CHEMBL491688 | N-hydroxy-3-(2-phenethyl-1-(3,4,5-t...)
Show SMILES COc1cc(Cn2c(CCc3ccccc3)nc3cc(\C=C\C(=O)NO)ccc23)cc(OC)c1OC
Show InChI InChI=1S/C28H29N3O5/c1-34-24-16-21(17-25(35-2)28(24)36-3)18-31-23-12-9-20(11-14-27(32)30-33)15-22(23)29-26(31)13-10-19-7-5-4-6-8-19/h4-9,11-12,14-17,33H,10,13,18H2,1-3H3,(H,30,32)/b14-11+
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n/an/an/an/a 1.70E+3n/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
To determine EC50 where acetylated histone 3 was induced by 50%, Colo205 cells was cultivated in 96 well plate at 1.5105 cells/well for 24 h. Colo20...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
Histone H3.1


(Homo sapiens (Human))
BDBM50248522
PNG
(CHEMBL489332 | N-hydroxy-3-(2-phenethyl-1-(2-(pipe...)
Show SMILES ONC(=O)\C=C\c1ccc2n(CCN3CCCCC3)c(CCc3ccccc3)nc2c1
Show InChI InChI=1S/C25H30N4O2/c30-25(27-31)14-11-21-9-12-23-22(19-21)26-24(13-10-20-7-3-1-4-8-20)29(23)18-17-28-15-5-2-6-16-28/h1,3-4,7-9,11-12,14,19,31H,2,5-6,10,13,15-18H2,(H,27,30)/b14-11+
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n/an/an/an/a 500n/an/an/an/a



MEI PHARMA, INC.

US Patent


Assay Description
To determine EC50 where acetylated histone 3 was induced by 50%, Colo205 cells was cultivated in 96 well plate at 1.5105 cells/well for 24 h. Colo20...


US Patent US10201527 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%