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Patent code US10202330

Compile Data Set for Download or QSAR
Found 54 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM339419
PNG
(US10202330, Example 10)
Show SMILES COc1ccc2CCC(N[C@H]3CC3c3ccc(cc3)-c3ccc(Cl)cc3)c2c1
Show InChI InChI=1S/C25H24ClNO/c1-28-21-12-8-19-9-13-24(22(19)14-21)27-25-15-23(25)18-4-2-16(3-5-18)17-6-10-20(26)11-7-17/h2-8,10-12,14,23-25,27H,9,13,15H2,1H3/t23?,24?,25-/m0/s1
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50n/an/an/an/an/an/an/an/a



ORYZON GENOMICS, SA

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US10202330 (2019)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM339426
PNG
(US10202330, Example 18)
Show SMILES Clc1ccc(cc1)-c1ccc(cc1)C1C[C@@H]1NCCC1CCCCC1
Show InChI InChI=1S/C23H28ClN/c24-21-12-10-19(11-13-21)18-6-8-20(9-7-18)22-16-23(22)25-15-14-17-4-2-1-3-5-17/h6-13,17,22-23,25H,1-5,14-16H2/t22?,23-/m0/s1
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50n/an/an/an/an/an/an/an/a



ORYZON GENOMICS, SA

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US10202330 (2019)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM339420
PNG
(US10202330, Example 11)
Show SMILES COc1ccc2CCC(N[C@H]3CC3c3ccc(cc3)-c3cccc(OC)c3)c2c1
Show InChI InChI=1S/C26H27NO2/c1-28-21-5-3-4-20(14-21)17-6-8-18(9-7-17)24-16-26(24)27-25-13-11-19-10-12-22(29-2)15-23(19)25/h3-10,12,14-15,24-27H,11,13,16H2,1-2H3/t24?,25?,26-/m0/s1
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50n/an/an/an/an/an/an/an/a



ORYZON GENOMICS, SA

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US10202330 (2019)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM339416
PNG
(US10202330, Example 7)
Show SMILES FC(F)(F)c1ccc2CCC(N[C@H]3CC3c3ccccc3)c2c1
Show InChI InChI=1S/C19H18F3N/c20-19(21,22)14-8-6-13-7-9-17(15(13)10-14)23-18-11-16(18)12-4-2-1-3-5-12/h1-6,8,10,16-18,23H,7,9,11H2/t16?,17?,18-/m0/s1
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550n/an/an/an/an/an/an/an/a



ORYZON GENOMICS, SA

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US10202330 (2019)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM339425
PNG
(US10202330, Example 16)
Show SMILES COc1ccc2CCC(N[C@H]3CC3c3ccc(OCc4cccc(Br)c4)cc3)c2c1
Show InChI InChI=1S/C26H26BrNO2/c1-29-22-11-7-19-8-12-25(23(19)14-22)28-26-15-24(26)18-5-9-21(10-6-18)30-16-17-3-2-4-20(27)13-17/h2-7,9-11,13-14,24-26,28H,8,12,15-16H2,1H3/t24?,25?,26-/m0/s1
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550n/an/an/an/an/an/an/an/a



ORYZON GENOMICS, SA

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US10202330 (2019)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM339410
PNG
(US10202330, Example 1)
Show SMILES COc1ccc2CCC(N[C@H]3CC3c3ccc(OCc4ccccc4)cc3)c2c1
Show InChI InChI=1S/C26H27NO2/c1-28-22-13-9-20-10-14-25(23(20)15-22)27-26-16-24(26)19-7-11-21(12-8-19)29-17-18-5-3-2-4-6-18/h2-9,11-13,15,24-27H,10,14,16-17H2,1H3/t24?,25?,26-/m0/s1
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550n/an/an/an/an/an/an/an/a



ORYZON GENOMICS, SA

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US10202330 (2019)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM339411
PNG
(US10202330, Example 2)
Show SMILES COc1cc2CCC(N[C@H]3CC3c3ccc(OCc4ccccc4)cc3)c2cc1OC
Show InChI InChI=1S/C27H29NO3/c1-29-26-14-20-10-13-24(23(20)16-27(26)30-2)28-25-15-22(25)19-8-11-21(12-9-19)31-17-18-6-4-3-5-7-18/h3-9,11-12,14,16,22,24-25,28H,10,13,15,17H2,1-2H3/t22?,24?,25-/m0/s1
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ORYZON GENOMICS, SA

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US10202330 (2019)

More data for this
Ligand-Target Pair
Monoamine oxidase


(Homo sapiens (Human))
BDBM339410
PNG
(US10202330, Example 1)
Show SMILES COc1ccc2CCC(N[C@H]3CC3c3ccc(OCc4ccccc4)cc3)c2c1
Show InChI InChI=1S/C26H27NO2/c1-28-22-13-9-20-10-14-25(23(20)15-22)27-26-16-24(26)19-7-11-21(12-8-19)29-17-18-5-3-2-4-6-18/h2-9,11-13,15,24-27H,10,14,16-17H2,1H3/t24?,25?,26-/m0/s1
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ORYZON GENOMICS, SA

US Patent


Assay Description
Briefly, a fixed amount of MAO (0.25 μg for MAO-A and 0.5 μg for MAO-B) was incubated on ice for 15 minutes in the reaction buffer, in the ...


US Patent US10202330 (2019)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM339423
PNG
(US10202330, Example 14)
Show SMILES C(CC1CCCCCC1)N[C@H]1CC1c1ccccc1
Show InChI InChI=1S/C18H27N/c1-2-5-9-15(8-4-1)12-13-19-18-14-17(18)16-10-6-3-7-11-16/h3,6-7,10-11,15,17-19H,1-2,4-5,8-9,12-14H2/t17?,18-/m0/s1
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ORYZON GENOMICS, SA

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US10202330 (2019)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM339422
PNG
(US10202330, Example 13)
Show SMILES C(CN[C@H]1CC1c1ccccc1)CC1CCCCC1
Show InChI InChI=1S/C18H27N/c1-3-8-15(9-4-1)10-7-13-19-18-14-17(18)16-11-5-2-6-12-16/h2,5-6,11-12,15,17-19H,1,3-4,7-10,13-14H2/t17?,18-/m0/s1
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ORYZON GENOMICS, SA

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US10202330 (2019)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM339421
PNG
(US10202330, Example 12)
Show SMILES C(CC1CCCCC1)N[C@H]1CC1c1ccccc1
Show InChI InChI=1S/C17H25N/c1-3-7-14(8-4-1)11-12-18-17-13-16(17)15-9-5-2-6-10-15/h2,5-6,9-10,14,16-18H,1,3-4,7-8,11-13H2/t16?,17-/m0/s1
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550n/an/an/an/an/an/an/an/a



ORYZON GENOMICS, SA

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US10202330 (2019)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM339415
PNG
(US10202330, Example 6)
Show SMILES Clc1ccc2CCC(N[C@H]3CC3c3ccccc3)c2c1
Show InChI InChI=1S/C18H18ClN/c19-14-8-6-13-7-9-17(15(13)10-14)20-18-11-16(18)12-4-2-1-3-5-12/h1-6,8,10,16-18,20H,7,9,11H2/t16?,17?,18-/m0/s1
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ORYZON GENOMICS, SA

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US10202330 (2019)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM339417
PNG
(US10202330, Example 8)
Show SMILES COc1ccc2CCCC(N[C@H]3CC3c3ccccc3)c2c1
Show InChI InChI=1S/C20H23NO/c1-22-16-11-10-15-8-5-9-19(17(15)12-16)21-20-13-18(20)14-6-3-2-4-7-14/h2-4,6-7,10-12,18-21H,5,8-9,13H2,1H3/t18?,19?,20-/m0/s1
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550n/an/an/an/an/an/an/an/a



ORYZON GENOMICS, SA

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US10202330 (2019)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM339414
PNG
(US10202330, Example 5)
Show SMILES COc1ccc2CCC(N[C@H]3CC3c3ccccc3)c2c1
Show InChI InChI=1S/C19H21NO/c1-21-15-9-7-14-8-10-18(16(14)11-15)20-19-12-17(19)13-5-3-2-4-6-13/h2-7,9,11,17-20H,8,10,12H2,1H3/t17?,18?,19-/m0/s1
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ORYZON GENOMICS, SA

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US10202330 (2019)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM339412
PNG
(US10202330, Example 3)
Show SMILES COc1ccc2C(CCc2c1OC)N[C@H]1CC1c1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C27H29NO3/c1-29-26-15-13-21-22(27(26)30-2)12-14-24(21)28-25-16-23(25)19-8-10-20(11-9-19)31-17-18-6-4-3-5-7-18/h3-11,13,15,23-25,28H,12,14,16-17H2,1-2H3/t23?,24?,25-/m0/s1
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550n/an/an/an/an/an/an/an/a



ORYZON GENOMICS, SA

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US10202330 (2019)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM339424
PNG
(US10202330, Example 15)
Show SMILES Brc1cccc(COc2ccc(cc2)C2C[C@@H]2NCCC2CCCCC2)c1
Show InChI InChI=1S/C24H30BrNO/c25-21-8-4-7-19(15-21)17-27-22-11-9-20(10-12-22)23-16-24(23)26-14-13-18-5-2-1-3-6-18/h4,7-12,15,18,23-24,26H,1-3,5-6,13-14,16-17H2/t23?,24-/m0/s1
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550n/an/an/an/an/an/an/an/a



ORYZON GENOMICS, SA

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US10202330 (2019)

More data for this
Ligand-Target Pair
Monoamine oxidase


(Homo sapiens (Human))
BDBM339424
PNG
(US10202330, Example 15)
Show SMILES Brc1cccc(COc2ccc(cc2)C2C[C@@H]2NCCC2CCCCC2)c1
Show InChI InChI=1S/C24H30BrNO/c25-21-8-4-7-19(15-21)17-27-22-11-9-20(10-12-22)23-16-24(23)26-14-13-18-5-2-1-3-6-18/h4,7-12,15,18,23-24,26H,1-3,5-6,13-14,16-17H2/t23?,24-/m0/s1
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550n/an/an/an/an/an/an/an/a



ORYZON GENOMICS, SA

US Patent


Assay Description
Briefly, a fixed amount of MAO (0.25 μg for MAO-A and 0.5 μg for MAO-B) was incubated on ice for 15 minutes in the reaction buffer, in the ...


US Patent US10202330 (2019)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM339418
PNG
(US10202330, Example 9)
Show SMILES COc1ccc2CCC(N[C@H]3CC3c3ccc(cc3)-c3cccc(Cl)c3)c2c1
Show InChI InChI=1S/C25H24ClNO/c1-28-21-11-9-18-10-12-24(22(18)14-21)27-25-15-23(25)17-7-5-16(6-8-17)19-3-2-4-20(26)13-19/h2-9,11,13-14,23-25,27H,10,12,15H2,1H3/t23?,24?,25-/m0/s1
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550n/an/an/an/an/an/an/an/a



ORYZON GENOMICS, SA

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US10202330 (2019)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM339427
PNG
(US10202330, Example 20)
Show SMILES COc1ccc2CCCC(CCN[C@H]3CC3c3ccc(OCc4ccccc4)cc3)c2c1
Show InChI InChI=1S/C29H33NO2/c1-31-26-15-12-22-8-5-9-23(27(22)18-26)16-17-30-29-19-28(29)24-10-13-25(14-11-24)32-20-21-6-3-2-4-7-21/h2-4,6-7,10-15,18,23,28-30H,5,8-9,16-17,19-20H2,1H3/t23?,28?,29-/m0/s1
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550n/an/an/an/an/an/an/an/a



ORYZON GENOMICS, SA

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US10202330 (2019)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM339413
PNG
(US10202330, Example 4)
Show SMILES C1[C@H](NC2CCc3ccccc23)C1c1ccccc1
Show InChI InChI=1S/C18H19N/c1-2-6-13(7-3-1)16-12-18(16)19-17-11-10-14-8-4-5-9-15(14)17/h1-9,16-19H,10-12H2/t16?,17?,18-/m0/s1
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550n/an/an/an/an/an/an/an/a



ORYZON GENOMICS, SA

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US10202330 (2019)

More data for this
Ligand-Target Pair
Monoamine oxidase


(Homo sapiens (Human))
BDBM339415
PNG
(US10202330, Example 6)
Show SMILES Clc1ccc2CCC(N[C@H]3CC3c3ccccc3)c2c1
Show InChI InChI=1S/C18H18ClN/c19-14-8-6-13-7-9-17(15(13)10-14)20-18-11-16(18)12-4-2-1-3-5-12/h1-6,8,10,16-18,20H,7,9,11H2/t16?,17?,18-/m0/s1
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2.05E+4n/an/an/an/an/an/an/an/a



ORYZON GENOMICS, SA

US Patent


Assay Description
Briefly, a fixed amount of MAO (0.25 μg for MAO-A and 0.5 μg for MAO-B) was incubated on ice for 15 minutes in the reaction buffer, in the ...


US Patent US10202330 (2019)

More data for this
Ligand-Target Pair
Monoamine oxidase


(Homo sapiens (Human))
BDBM339427
PNG
(US10202330, Example 20)
Show SMILES COc1ccc2CCCC(CCN[C@H]3CC3c3ccc(OCc4ccccc4)cc3)c2c1
Show InChI InChI=1S/C29H33NO2/c1-31-26-15-12-22-8-5-9-23(27(22)18-26)16-17-30-29-19-28(29)24-10-13-25(14-11-24)32-20-21-6-3-2-4-7-21/h2-4,6-7,10-15,18,23,28-30H,5,8-9,16-17,19-20H2,1H3/t23?,28?,29-/m0/s1
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2.05E+4n/an/an/an/an/an/an/an/a



ORYZON GENOMICS, SA

US Patent


Assay Description
Briefly, a fixed amount of MAO (0.25 μg for MAO-A and 0.5 μg for MAO-B) was incubated on ice for 15 minutes in the reaction buffer, in the ...


US Patent US10202330 (2019)

More data for this
Ligand-Target Pair
Monoamine oxidase


(Homo sapiens (Human))
BDBM339419
PNG
(US10202330, Example 10)
Show SMILES COc1ccc2CCC(N[C@H]3CC3c3ccc(cc3)-c3ccc(Cl)cc3)c2c1
Show InChI InChI=1S/C25H24ClNO/c1-28-21-12-8-19-9-13-24(22(19)14-21)27-25-15-23(25)18-4-2-16(3-5-18)17-6-10-20(26)11-7-17/h2-8,10-12,14,23-25,27H,9,13,15H2,1H3/t23?,24?,25-/m0/s1
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2.05E+4n/an/an/an/an/an/an/an/a



ORYZON GENOMICS, SA

US Patent


Assay Description
Briefly, a fixed amount of MAO (0.25 μg for MAO-A and 0.5 μg for MAO-B) was incubated on ice for 15 minutes in the reaction buffer, in the ...


US Patent US10202330 (2019)

More data for this
Ligand-Target Pair
Monoamine oxidase


(Homo sapiens (Human))
BDBM339417
PNG
(US10202330, Example 8)
Show SMILES COc1ccc2CCCC(N[C@H]3CC3c3ccccc3)c2c1
Show InChI InChI=1S/C20H23NO/c1-22-16-11-10-15-8-5-9-19(17(15)12-16)21-20-13-18(20)14-6-3-2-4-7-14/h2-4,6-7,10-12,18-21H,5,8-9,13H2,1H3/t18?,19?,20-/m0/s1
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ORYZON GENOMICS, SA

US Patent


Assay Description
Briefly, a fixed amount of MAO (0.25 μg for MAO-A and 0.5 μg for MAO-B) was incubated on ice for 15 minutes in the reaction buffer, in the ...


US Patent US10202330 (2019)

More data for this
Ligand-Target Pair
Monoamine oxidase


(Homo sapiens (Human))
BDBM339414
PNG
(US10202330, Example 5)
Show SMILES COc1ccc2CCC(N[C@H]3CC3c3ccccc3)c2c1
Show InChI InChI=1S/C19H21NO/c1-21-15-9-7-14-8-10-18(16(14)11-15)20-19-12-17(19)13-5-3-2-4-6-13/h2-7,9,11,17-20H,8,10,12H2,1H3/t17?,18?,19-/m0/s1
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ORYZON GENOMICS, SA

US Patent


Assay Description
Briefly, a fixed amount of MAO (0.25 μg for MAO-A and 0.5 μg for MAO-B) was incubated on ice for 15 minutes in the reaction buffer, in the ...


US Patent US10202330 (2019)

More data for this
Ligand-Target Pair
Monoamine oxidase


(Homo sapiens (Human))
BDBM339412
PNG
(US10202330, Example 3)
Show SMILES COc1ccc2C(CCc2c1OC)N[C@H]1CC1c1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C27H29NO3/c1-29-26-15-13-21-22(27(26)30-2)12-14-24(21)28-25-16-23(25)19-8-10-20(11-9-19)31-17-18-6-4-3-5-7-18/h3-11,13,15,23-25,28H,12,14,16-17H2,1-2H3/t23?,24?,25-/m0/s1
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ORYZON GENOMICS, SA

US Patent


Assay Description
Briefly, a fixed amount of MAO (0.25 μg for MAO-A and 0.5 μg for MAO-B) was incubated on ice for 15 minutes in the reaction buffer, in the ...


US Patent US10202330 (2019)

More data for this
Ligand-Target Pair
Monoamine oxidase


(Homo sapiens (Human))
BDBM339426
PNG
(US10202330, Example 18)
Show SMILES Clc1ccc(cc1)-c1ccc(cc1)C1C[C@@H]1NCCC1CCCCC1
Show InChI InChI=1S/C23H28ClN/c24-21-12-10-19(11-13-21)18-6-8-20(9-7-18)22-16-23(22)25-15-14-17-4-2-1-3-5-17/h6-13,17,22-23,25H,1-5,14-16H2/t22?,23-/m0/s1
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ORYZON GENOMICS, SA

US Patent


Assay Description
Briefly, a fixed amount of MAO (0.25 μg for MAO-A and 0.5 μg for MAO-B) was incubated on ice for 15 minutes in the reaction buffer, in the ...


US Patent US10202330 (2019)

More data for this
Ligand-Target Pair
Monoamine oxidase


(Homo sapiens (Human))
BDBM339422
PNG
(US10202330, Example 13)
Show SMILES C(CN[C@H]1CC1c1ccccc1)CC1CCCCC1
Show InChI InChI=1S/C18H27N/c1-3-8-15(9-4-1)10-7-13-19-18-14-17(18)16-11-5-2-6-12-16/h2,5-6,11-12,15,17-19H,1,3-4,7-10,13-14H2/t17?,18-/m0/s1
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2.05E+4n/an/an/an/an/an/an/an/a



ORYZON GENOMICS, SA

US Patent


Assay Description
Briefly, a fixed amount of MAO (0.25 μg for MAO-A and 0.5 μg for MAO-B) was incubated on ice for 15 minutes in the reaction buffer, in the ...


US Patent US10202330 (2019)

More data for this
Ligand-Target Pair
Monoamine oxidase


(Homo sapiens (Human))
BDBM339425
PNG
(US10202330, Example 16)
Show SMILES COc1ccc2CCC(N[C@H]3CC3c3ccc(OCc4cccc(Br)c4)cc3)c2c1
Show InChI InChI=1S/C26H26BrNO2/c1-29-22-11-7-19-8-12-25(23(19)14-22)28-26-15-24(26)18-5-9-21(10-6-18)30-16-17-3-2-4-20(27)13-17/h2-7,9-11,13-14,24-26,28H,8,12,15-16H2,1H3/t24?,25?,26-/m0/s1
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2.05E+4n/an/an/an/an/an/an/an/a



ORYZON GENOMICS, SA

US Patent


Assay Description
Briefly, a fixed amount of MAO (0.25 μg for MAO-A and 0.5 μg for MAO-B) was incubated on ice for 15 minutes in the reaction buffer, in the ...


US Patent US10202330 (2019)

More data for this
Ligand-Target Pair
Monoamine oxidase


(Homo sapiens (Human))
BDBM339415
PNG
(US10202330, Example 6)
Show SMILES Clc1ccc2CCC(N[C@H]3CC3c3ccccc3)c2c1
Show InChI InChI=1S/C18H18ClN/c19-14-8-6-13-7-9-17(15(13)10-14)20-18-11-16(18)12-4-2-1-3-5-12/h1-6,8,10,16-18,20H,7,9,11H2/t16?,17?,18-/m0/s1
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2.05E+4n/an/an/an/an/an/an/an/a



ORYZON GENOMICS, SA

US Patent


Assay Description
Briefly, a fixed amount of MAO (0.25 μg for MAO-A and 0.5 μg for MAO-B) was incubated on ice for 15 minutes in the reaction buffer, in the ...


US Patent US10202330 (2019)

More data for this
Ligand-Target Pair
Monoamine oxidase


(Homo sapiens (Human))
BDBM339412
PNG
(US10202330, Example 3)
Show SMILES COc1ccc2C(CCc2c1OC)N[C@H]1CC1c1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C27H29NO3/c1-29-26-15-13-21-22(27(26)30-2)12-14-24(21)28-25-16-23(25)19-8-10-20(11-9-19)31-17-18-6-4-3-5-7-18/h3-11,13,15,23-25,28H,12,14,16-17H2,1-2H3/t23?,24?,25-/m0/s1
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2.05E+4n/an/an/an/an/an/an/an/a



ORYZON GENOMICS, SA

US Patent


Assay Description
Briefly, a fixed amount of MAO (0.25 μg for MAO-A and 0.5 μg for MAO-B) was incubated on ice for 15 minutes in the reaction buffer, in the ...


US Patent US10202330 (2019)

More data for this
Ligand-Target Pair
Monoamine oxidase


(Homo sapiens (Human))
BDBM339410
PNG
(US10202330, Example 1)
Show SMILES COc1ccc2CCC(N[C@H]3CC3c3ccc(OCc4ccccc4)cc3)c2c1
Show InChI InChI=1S/C26H27NO2/c1-28-22-13-9-20-10-14-25(23(20)15-22)27-26-16-24(26)19-7-11-21(12-8-19)29-17-18-5-3-2-4-6-18/h2-9,11-13,15,24-27H,10,14,16-17H2,1H3/t24?,25?,26-/m0/s1
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2.05E+4n/an/an/an/an/an/an/an/a



ORYZON GENOMICS, SA

US Patent


Assay Description
Briefly, a fixed amount of MAO (0.25 μg for MAO-A and 0.5 μg for MAO-B) was incubated on ice for 15 minutes in the reaction buffer, in the ...


US Patent US10202330 (2019)

More data for this
Ligand-Target Pair
Monoamine oxidase


(Homo sapiens (Human))
BDBM339418
PNG
(US10202330, Example 9)
Show SMILES COc1ccc2CCC(N[C@H]3CC3c3ccc(cc3)-c3cccc(Cl)c3)c2c1
Show InChI InChI=1S/C25H24ClNO/c1-28-21-11-9-18-10-12-24(22(18)14-21)27-25-15-23(25)17-7-5-16(6-8-17)19-3-2-4-20(26)13-19/h2-9,11,13-14,23-25,27H,10,12,15H2,1H3/t23?,24?,25-/m0/s1
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2.05E+4n/an/an/an/an/an/an/an/a



ORYZON GENOMICS, SA

US Patent


Assay Description
Briefly, a fixed amount of MAO (0.25 μg for MAO-A and 0.5 μg for MAO-B) was incubated on ice for 15 minutes in the reaction buffer, in the ...


US Patent US10202330 (2019)

More data for this
Ligand-Target Pair
Monoamine oxidase


(Homo sapiens (Human))
BDBM339413
PNG
(US10202330, Example 4)
Show SMILES C1[C@H](NC2CCc3ccccc23)C1c1ccccc1
Show InChI InChI=1S/C18H19N/c1-2-6-13(7-3-1)16-12-18(16)19-17-11-10-14-8-4-5-9-15(14)17/h1-9,16-19H,10-12H2/t16?,17?,18-/m0/s1
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2.05E+4n/an/an/an/an/an/an/an/a



ORYZON GENOMICS, SA

US Patent


Assay Description
Briefly, a fixed amount of MAO (0.25 μg for MAO-A and 0.5 μg for MAO-B) was incubated on ice for 15 minutes in the reaction buffer, in the ...


US Patent US10202330 (2019)

More data for this
Ligand-Target Pair
Monoamine oxidase


(Homo sapiens (Human))
BDBM339425
PNG
(US10202330, Example 16)
Show SMILES COc1ccc2CCC(N[C@H]3CC3c3ccc(OCc4cccc(Br)c4)cc3)c2c1
Show InChI InChI=1S/C26H26BrNO2/c1-29-22-11-7-19-8-12-25(23(19)14-22)28-26-15-24(26)18-5-9-21(10-6-18)30-16-17-3-2-4-20(27)13-17/h2-7,9-11,13-14,24-26,28H,8,12,15-16H2,1H3/t24?,25?,26-/m0/s1
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2.05E+4n/an/an/an/an/an/an/an/a



ORYZON GENOMICS, SA

US Patent


Assay Description
Briefly, a fixed amount of MAO (0.25 μg for MAO-A and 0.5 μg for MAO-B) was incubated on ice for 15 minutes in the reaction buffer, in the ...


US Patent US10202330 (2019)

More data for this
Ligand-Target Pair
Monoamine oxidase


(Homo sapiens (Human))
BDBM339420
PNG
(US10202330, Example 11)
Show SMILES COc1ccc2CCC(N[C@H]3CC3c3ccc(cc3)-c3cccc(OC)c3)c2c1
Show InChI InChI=1S/C26H27NO2/c1-28-21-5-3-4-20(14-21)17-6-8-18(9-7-17)24-16-26(24)27-25-13-11-19-10-12-22(29-2)15-23(19)25/h3-10,12,14-15,24-27H,11,13,16H2,1-2H3/t24?,25?,26-/m0/s1
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2.05E+4n/an/an/an/an/an/an/an/a



ORYZON GENOMICS, SA

US Patent


Assay Description
Briefly, a fixed amount of MAO (0.25 μg for MAO-A and 0.5 μg for MAO-B) was incubated on ice for 15 minutes in the reaction buffer, in the ...


US Patent US10202330 (2019)

More data for this
Ligand-Target Pair
Monoamine oxidase


(Homo sapiens (Human))
BDBM339420
PNG
(US10202330, Example 11)
Show SMILES COc1ccc2CCC(N[C@H]3CC3c3ccc(cc3)-c3cccc(OC)c3)c2c1
Show InChI InChI=1S/C26H27NO2/c1-28-21-5-3-4-20(14-21)17-6-8-18(9-7-17)24-16-26(24)27-25-13-11-19-10-12-22(29-2)15-23(19)25/h3-10,12,14-15,24-27H,11,13,16H2,1-2H3/t24?,25?,26-/m0/s1
PDB

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2.05E+4n/an/an/an/an/an/an/an/a



ORYZON GENOMICS, SA

US Patent


Assay Description
Briefly, a fixed amount of MAO (0.25 μg for MAO-A and 0.5 μg for MAO-B) was incubated on ice for 15 minutes in the reaction buffer, in the ...


US Patent US10202330 (2019)

More data for this
Ligand-Target Pair
Monoamine oxidase


(Homo sapiens (Human))
BDBM339423
PNG
(US10202330, Example 14)
Show SMILES C(CC1CCCCCC1)N[C@H]1CC1c1ccccc1
Show InChI InChI=1S/C18H27N/c1-2-5-9-15(8-4-1)12-13-19-18-14-17(18)16-10-6-3-7-11-16/h3,6-7,10-11,15,17-19H,1-2,4-5,8-9,12-14H2/t17?,18-/m0/s1
PDB

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2.05E+4n/an/an/an/an/an/an/an/a



ORYZON GENOMICS, SA

US Patent


Assay Description
Briefly, a fixed amount of MAO (0.25 μg for MAO-A and 0.5 μg for MAO-B) was incubated on ice for 15 minutes in the reaction buffer, in the ...


US Patent US10202330 (2019)

More data for this
Ligand-Target Pair
Monoamine oxidase


(Homo sapiens (Human))
BDBM339421
PNG
(US10202330, Example 12)
Show SMILES C(CC1CCCCC1)N[C@H]1CC1c1ccccc1
Show InChI InChI=1S/C17H25N/c1-3-7-14(8-4-1)11-12-18-17-13-16(17)15-9-5-2-6-10-15/h2,5-6,9-10,14,16-18H,1,3-4,7-8,11-13H2/t16?,17-/m0/s1
PDB

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2.05E+4n/an/an/an/an/an/an/an/a



ORYZON GENOMICS, SA

US Patent


Assay Description
Briefly, a fixed amount of MAO (0.25 μg for MAO-A and 0.5 μg for MAO-B) was incubated on ice for 15 minutes in the reaction buffer, in the ...


US Patent US10202330 (2019)

More data for this
Ligand-Target Pair
Monoamine oxidase


(Homo sapiens (Human))
BDBM339417
PNG
(US10202330, Example 8)
Show SMILES COc1ccc2CCCC(N[C@H]3CC3c3ccccc3)c2c1
Show InChI InChI=1S/C20H23NO/c1-22-16-11-10-15-8-5-9-19(17(15)12-16)21-20-13-18(20)14-6-3-2-4-7-14/h2-4,6-7,10-12,18-21H,5,8-9,13H2,1H3/t18?,19?,20-/m0/s1
PDB

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2.05E+4n/an/an/an/an/an/an/an/a



ORYZON GENOMICS, SA

US Patent


Assay Description
Briefly, a fixed amount of MAO (0.25 μg for MAO-A and 0.5 μg for MAO-B) was incubated on ice for 15 minutes in the reaction buffer, in the ...


US Patent US10202330 (2019)

More data for this
Ligand-Target Pair
Monoamine oxidase


(Homo sapiens (Human))
BDBM339414
PNG
(US10202330, Example 5)
Show SMILES COc1ccc2CCC(N[C@H]3CC3c3ccccc3)c2c1
Show InChI InChI=1S/C19H21NO/c1-21-15-9-7-14-8-10-18(16(14)11-15)20-19-12-17(19)13-5-3-2-4-6-13/h2-7,9,11,17-20H,8,10,12H2,1H3/t17?,18?,19-/m0/s1
PDB

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2.05E+4n/an/an/an/an/an/an/an/a



ORYZON GENOMICS, SA

US Patent


Assay Description
Briefly, a fixed amount of MAO (0.25 μg for MAO-A and 0.5 μg for MAO-B) was incubated on ice for 15 minutes in the reaction buffer, in the ...


US Patent US10202330 (2019)

More data for this
Ligand-Target Pair
Monoamine oxidase


(Homo sapiens (Human))
BDBM339418
PNG
(US10202330, Example 9)
Show SMILES COc1ccc2CCC(N[C@H]3CC3c3ccc(cc3)-c3cccc(Cl)c3)c2c1
Show InChI InChI=1S/C25H24ClNO/c1-28-21-11-9-18-10-12-24(22(18)14-21)27-25-15-23(25)17-7-5-16(6-8-17)19-3-2-4-20(26)13-19/h2-9,11,13-14,23-25,27H,10,12,15H2,1H3/t23?,24?,25-/m0/s1
PDB

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2.05E+4n/an/an/an/an/an/an/an/a



ORYZON GENOMICS, SA

US Patent


Assay Description
Briefly, a fixed amount of MAO (0.25 μg for MAO-A and 0.5 μg for MAO-B) was incubated on ice for 15 minutes in the reaction buffer, in the ...


US Patent US10202330 (2019)

More data for this
Ligand-Target Pair
Monoamine oxidase


(Homo sapiens (Human))
BDBM339424
PNG
(US10202330, Example 15)
Show SMILES Brc1cccc(COc2ccc(cc2)C2C[C@@H]2NCCC2CCCCC2)c1
Show InChI InChI=1S/C24H30BrNO/c25-21-8-4-7-19(15-21)17-27-22-11-9-20(10-12-22)23-16-24(23)26-14-13-18-5-2-1-3-6-18/h4,7-12,15,18,23-24,26H,1-3,5-6,13-14,16-17H2/t23?,24-/m0/s1
PDB

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2.05E+4n/an/an/an/an/an/an/an/a



ORYZON GENOMICS, SA

US Patent


Assay Description
Briefly, a fixed amount of MAO (0.25 μg for MAO-A and 0.5 μg for MAO-B) was incubated on ice for 15 minutes in the reaction buffer, in the ...


US Patent US10202330 (2019)

More data for this
Ligand-Target Pair
Monoamine oxidase


(Homo sapiens (Human))
BDBM339421
PNG
(US10202330, Example 12)
Show SMILES C(CC1CCCCC1)N[C@H]1CC1c1ccccc1
Show InChI InChI=1S/C17H25N/c1-3-7-14(8-4-1)11-12-18-17-13-16(17)15-9-5-2-6-10-15/h2,5-6,9-10,14,16-18H,1,3-4,7-8,11-13H2/t16?,17-/m0/s1
PDB

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2.05E+4n/an/an/an/an/an/an/an/a



ORYZON GENOMICS, SA

US Patent


Assay Description
Briefly, a fixed amount of MAO (0.25 μg for MAO-A and 0.5 μg for MAO-B) was incubated on ice for 15 minutes in the reaction buffer, in the ...


US Patent US10202330 (2019)

More data for this
Ligand-Target Pair
Monoamine oxidase


(Homo sapiens (Human))
BDBM339423
PNG
(US10202330, Example 14)
Show SMILES C(CC1CCCCCC1)N[C@H]1CC1c1ccccc1
Show InChI InChI=1S/C18H27N/c1-2-5-9-15(8-4-1)12-13-19-18-14-17(18)16-10-6-3-7-11-16/h3,6-7,10-11,15,17-19H,1-2,4-5,8-9,12-14H2/t17?,18-/m0/s1
PDB

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2.05E+4n/an/an/an/an/an/an/an/a



ORYZON GENOMICS, SA

US Patent


Assay Description
Briefly, a fixed amount of MAO (0.25 μg for MAO-A and 0.5 μg for MAO-B) was incubated on ice for 15 minutes in the reaction buffer, in the ...


US Patent US10202330 (2019)

More data for this
Ligand-Target Pair
Monoamine oxidase


(Homo sapiens (Human))
BDBM339426
PNG
(US10202330, Example 18)
Show SMILES Clc1ccc(cc1)-c1ccc(cc1)C1C[C@@H]1NCCC1CCCCC1
Show InChI InChI=1S/C23H28ClN/c24-21-12-10-19(11-13-21)18-6-8-20(9-7-18)22-16-23(22)25-15-14-17-4-2-1-3-5-17/h6-13,17,22-23,25H,1-5,14-16H2/t22?,23-/m0/s1
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2.05E+4n/an/an/an/an/an/an/an/a



ORYZON GENOMICS, SA

US Patent


Assay Description
Briefly, a fixed amount of MAO (0.25 μg for MAO-A and 0.5 μg for MAO-B) was incubated on ice for 15 minutes in the reaction buffer, in the ...


US Patent US10202330 (2019)

More data for this
Ligand-Target Pair
Monoamine oxidase


(Homo sapiens (Human))
BDBM339427
PNG
(US10202330, Example 20)
Show SMILES COc1ccc2CCCC(CCN[C@H]3CC3c3ccc(OCc4ccccc4)cc3)c2c1
Show InChI InChI=1S/C29H33NO2/c1-31-26-15-12-22-8-5-9-23(27(22)18-26)16-17-30-29-19-28(29)24-10-13-25(14-11-24)32-20-21-6-3-2-4-7-21/h2-4,6-7,10-15,18,23,28-30H,5,8-9,16-17,19-20H2,1H3/t23?,28?,29-/m0/s1
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2.05E+4n/an/an/an/an/an/an/an/a



ORYZON GENOMICS, SA

US Patent


Assay Description
Briefly, a fixed amount of MAO (0.25 μg for MAO-A and 0.5 μg for MAO-B) was incubated on ice for 15 minutes in the reaction buffer, in the ...


US Patent US10202330 (2019)

More data for this
Ligand-Target Pair
Monoamine oxidase


(Homo sapiens (Human))
BDBM339411
PNG
(US10202330, Example 2)
Show SMILES COc1cc2CCC(N[C@H]3CC3c3ccc(OCc4ccccc4)cc3)c2cc1OC
Show InChI InChI=1S/C27H29NO3/c1-29-26-14-20-10-13-24(23(20)16-27(26)30-2)28-25-15-22(25)19-8-11-21(12-9-19)31-17-18-6-4-3-5-7-18/h3-9,11-12,14,16,22,24-25,28H,10,13,15,17H2,1-2H3/t22?,24?,25-/m0/s1
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2.05E+4n/an/an/an/an/an/an/an/a



ORYZON GENOMICS, SA

US Patent


Assay Description
Briefly, a fixed amount of MAO (0.25 μg for MAO-A and 0.5 μg for MAO-B) was incubated on ice for 15 minutes in the reaction buffer, in the ...


US Patent US10202330 (2019)

More data for this
Ligand-Target Pair
Monoamine oxidase


(Homo sapiens (Human))
BDBM339411
PNG
(US10202330, Example 2)
Show SMILES COc1cc2CCC(N[C@H]3CC3c3ccc(OCc4ccccc4)cc3)c2cc1OC
Show InChI InChI=1S/C27H29NO3/c1-29-26-14-20-10-13-24(23(20)16-27(26)30-2)28-25-15-22(25)19-8-11-21(12-9-19)31-17-18-6-4-3-5-7-18/h3-9,11-12,14,16,22,24-25,28H,10,13,15,17H2,1-2H3/t22?,24?,25-/m0/s1
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2.05E+4n/an/an/an/an/an/an/an/a



ORYZON GENOMICS, SA

US Patent


Assay Description
Briefly, a fixed amount of MAO (0.25 μg for MAO-A and 0.5 μg for MAO-B) was incubated on ice for 15 minutes in the reaction buffer, in the ...


US Patent US10202330 (2019)

More data for this
Ligand-Target Pair
Monoamine oxidase


(Homo sapiens (Human))
BDBM339413
PNG
(US10202330, Example 4)
Show SMILES C1[C@H](NC2CCc3ccccc23)C1c1ccccc1
Show InChI InChI=1S/C18H19N/c1-2-6-13(7-3-1)16-12-18(16)19-17-11-10-14-8-4-5-9-15(14)17/h1-9,16-19H,10-12H2/t16?,17?,18-/m0/s1
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2.05E+4n/an/an/an/an/an/an/an/a



ORYZON GENOMICS, SA

US Patent


Assay Description
Briefly, a fixed amount of MAO (0.25 μg for MAO-A and 0.5 μg for MAO-B) was incubated on ice for 15 minutes in the reaction buffer, in the ...


US Patent US10202330 (2019)

More data for this
Ligand-Target Pair
Monoamine oxidase


(Homo sapiens (Human))
BDBM339419
PNG
(US10202330, Example 10)
Show SMILES COc1ccc2CCC(N[C@H]3CC3c3ccc(cc3)-c3ccc(Cl)cc3)c2c1
Show InChI InChI=1S/C25H24ClNO/c1-28-21-12-8-19-9-13-24(22(19)14-21)27-25-15-23(25)18-4-2-16(3-5-18)17-6-10-20(26)11-7-17/h2-8,10-12,14,23-25,27H,9,13,15H2,1H3/t23?,24?,25-/m0/s1
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2.05E+4n/an/an/an/an/an/an/an/a



ORYZON GENOMICS, SA

US Patent


Assay Description
Briefly, a fixed amount of MAO (0.25 μg for MAO-A and 0.5 μg for MAO-B) was incubated on ice for 15 minutes in the reaction buffer, in the ...


US Patent US10202330 (2019)

More data for this
Ligand-Target Pair
Monoamine oxidase


(Homo sapiens (Human))
BDBM339422
PNG
(US10202330, Example 13)
Show SMILES C(CN[C@H]1CC1c1ccccc1)CC1CCCCC1
Show InChI InChI=1S/C18H27N/c1-3-8-15(9-4-1)10-7-13-19-18-14-17(18)16-11-5-2-6-12-16/h2,5-6,11-12,15,17-19H,1,3-4,7-10,13-14H2/t17?,18-/m0/s1
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2.05E+4n/an/an/an/an/an/an/an/a



ORYZON GENOMICS, SA

US Patent


Assay Description
Briefly, a fixed amount of MAO (0.25 μg for MAO-A and 0.5 μg for MAO-B) was incubated on ice for 15 minutes in the reaction buffer, in the ...


US Patent US10202330 (2019)

More data for this
Ligand-Target Pair
Monoamine oxidase


(Homo sapiens (Human))
BDBM339416
PNG
(US10202330, Example 7)
Show SMILES FC(F)(F)c1ccc2CCC(N[C@H]3CC3c3ccccc3)c2c1
Show InChI InChI=1S/C19H18F3N/c20-19(21,22)14-8-6-13-7-9-17(15(13)10-14)23-18-11-16(18)12-4-2-1-3-5-12/h1-6,8,10,16-18,23H,7,9,11H2/t16?,17?,18-/m0/s1
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>4.00E+4n/an/an/an/an/an/an/an/a



ORYZON GENOMICS, SA

US Patent


Assay Description
Briefly, a fixed amount of MAO (0.25 μg for MAO-A and 0.5 μg for MAO-B) was incubated on ice for 15 minutes in the reaction buffer, in the ...


US Patent US10202330 (2019)

More data for this
Ligand-Target Pair
Monoamine oxidase


(Homo sapiens (Human))
BDBM339416
PNG
(US10202330, Example 7)
Show SMILES FC(F)(F)c1ccc2CCC(N[C@H]3CC3c3ccccc3)c2c1
Show InChI InChI=1S/C19H18F3N/c20-19(21,22)14-8-6-13-7-9-17(15(13)10-14)23-18-11-16(18)12-4-2-1-3-5-12/h1-6,8,10,16-18,23H,7,9,11H2/t16?,17?,18-/m0/s1
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>4.00E+4n/an/an/an/an/an/an/an/a



ORYZON GENOMICS, SA

US Patent


Assay Description
Briefly, a fixed amount of MAO (0.25 μg for MAO-A and 0.5 μg for MAO-B) was incubated on ice for 15 minutes in the reaction buffer, in the ...


US Patent US10202330 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%