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Patent code US10202350

Compile Data Set for Download or QSAR
Found 187 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345281
PNG
(2-[[1-[(2-Chlorophenyl)methyl]-5-(3- isobutoxyphe...)
Show SMILES CC(C)COc1cccc(c1)-c1cc(COC(C)(C)C(O)=O)nn1Cc1ccccc1Cl
Show InChI InChI=1S/C25H29ClN2O4/c1-17(2)15-31-21-10-7-9-18(12-21)23-13-20(16-32-25(3,4)24(29)30)27-28(23)14-19-8-5-6-11-22(19)26/h5-13,17H,14-16H2,1-4H3,(H,29,30)
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Vettore, LLC

US Patent


Assay Description
MDA-MB-231 breast cancer cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known to ...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345298
PNG
(2-[[1-[(2-Chlorophenyl)methyl]-5-[3- (cyclopentyl...)
Show SMILES CC(C)(OCc1cc(-c2cccc(OCC3CCCC3)c2)n(Cc2ccccc2Cl)n1)C(O)=O
Show InChI InChI=1S/C27H31ClN2O4/c1-27(2,26(31)32)34-18-22-15-25(30(29-22)16-21-10-5-6-13-24(21)28)20-11-7-12-23(14-20)33-17-19-8-3-4-9-19/h5-7,10-15,19H,3-4,8-9,16-18H2,1-2H3,(H,31,32)
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Vettore, LLC

US Patent


Assay Description
MDA-MB-231 breast cancer cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known to ...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345296
PNG
(2-[[1-[(2-Chlorophenyl)methyl]-5-[3- (cyclobutylm...)
Show SMILES CC(C)(OCc1cc(-c2cccc(OCC3CCC3)c2)n(Cc2ccccc2Cl)n1)C(O)=O
Show InChI InChI=1S/C26H29ClN2O4/c1-26(2,25(30)31)33-17-21-14-24(29(28-21)15-20-9-3-4-12-23(20)27)19-10-6-11-22(13-19)32-16-18-7-5-8-18/h3-4,6,9-14,18H,5,7-8,15-17H2,1-2H3,(H,30,31)
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US Patent


Assay Description
MDA-MB-231 breast cancer cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known to ...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345315
PNG
(2-([1-[(2-methoxyphenyl)methyl]-5-[3-(2- methylpr...)
Show SMILES COc1ccccc1Cn1nc(COC(C)(C)C(O)=O)cc1-c1cccc(OCC(C)C)c1
Show InChI InChI=1S/C26H32N2O5/c1-18(2)16-32-22-11-8-10-19(13-22)23-14-21(17-33-26(3,4)25(29)30)27-28(23)15-20-9-6-7-12-24(20)31-5/h6-14,18H,15-17H2,1-5H3,(H,29,30)
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US Patent


Assay Description
MDA-MB-231 breast cancer cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known to ...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345287
PNG
(2-[[1-[(2-Chlorophenyl)methyl]-5-[3- (cyclopropyl...)
Show SMILES CC(C)(OCc1cc(-c2cccc(OCC3CC3)c2)n(Cc2ccccc2Cl)n1)C(O)=O
Show InChI InChI=1S/C25H27ClN2O4/c1-25(2,24(29)30)32-16-20-13-23(28(27-20)14-19-6-3-4-9-22(19)26)18-7-5-8-21(12-18)31-15-17-10-11-17/h3-9,12-13,17H,10-11,14-16H2,1-2H3,(H,29,30)
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US Patent


Assay Description
MDA-MB-231 breast cancer cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known to ...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345283
PNG
(2-[[1-[(2-Bromophenyl)methyl]-5-(3- isopropoxyphe...)
Show SMILES CC(C)Oc1cccc(c1)-c1cc(COC(C)(C)C(O)=O)nn1Cc1ccccc1Br
Show InChI InChI=1S/C24H27BrN2O4/c1-16(2)31-20-10-7-9-17(12-20)22-13-19(15-30-24(3,4)23(28)29)26-27(22)14-18-8-5-6-11-21(18)25/h5-13,16H,14-15H2,1-4H3,(H,28,29)
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US Patent


Assay Description
MDA-MB-231 breast cancer cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known to ...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345289
PNG
(2-[[1-[(2-Chlorophenyl)methyl]-5-(3- isopropoxyph...)
Show SMILES CC(C)Oc1cccc(c1)-c1cc(COC(C)(C)C(O)=O)nn1Cc1ccccc1Cl
Show InChI InChI=1S/C24H27ClN2O4/c1-16(2)31-20-10-7-9-17(12-20)22-13-19(15-30-24(3,4)23(28)29)26-27(22)14-18-8-5-6-11-21(18)25/h5-13,16H,14-15H2,1-4H3,(H,28,29)
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US Patent


Assay Description
MDA-MB-231 breast cancer cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known to ...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345293
PNG
(2-[[1-[(2-Chlorophenyl)methyl]-5-[3- (cyclopropox...)
Show SMILES CC(C)(OCc1cc(-c2cccc(OC3CC3)c2)n(Cc2ccccc2Cl)n1)C(O)=O
Show InChI InChI=1S/C24H25ClN2O4/c1-24(2,23(28)29)30-15-18-13-22(16-7-5-8-20(12-16)31-19-10-11-19)27(26-18)14-17-6-3-4-9-21(17)25/h3-9,12-13,19H,10-11,14-15H2,1-2H3,(H,28,29)
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Assay Description
MDA-MB-231 breast cancer cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known to ...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345291
PNG
(2-[[1-[(2-Chlorophenyl)methyl]-5-[3- (cyclobutoxy...)
Show SMILES CC(C)(OCc1cc(-c2cccc(OC3CCC3)c2)n(Cc2ccccc2Cl)n1)C(O)=O
Show InChI InChI=1S/C25H27ClN2O4/c1-25(2,24(29)30)31-16-19-14-23(28(27-19)15-18-7-3-4-12-22(18)26)17-8-5-11-21(13-17)32-20-9-6-10-20/h3-5,7-8,11-14,20H,6,9-10,15-16H2,1-2H3,(H,29,30)
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US Patent


Assay Description
MDA-MB-231 breast cancer cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known to ...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345320
PNG
(2-([1-[(2-chlorophenyl)methyl]-5-(5-methoxythiophe...)
Show SMILES COc1cc(cs1)-c1cc(COC(C)(C)C(O)=O)nn1Cc1ccccc1Cl
Show InChI InChI=1S/C20H21ClN2O4S/c1-20(2,19(24)25)27-11-15-9-17(14-8-18(26-3)28-12-14)23(22-15)10-13-6-4-5-7-16(13)21/h4-9,12H,10-11H2,1-3H3,(H,24,25)
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Assay Description
MDA-MB-231 breast cancer cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known to ...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345319
PNG
(US10202350, Example 65)
Show SMILES COc1csc(c1)-c1cc(COC(C)(C)C(O)=O)nn1Cc1ccccc1Cl
Show InChI InChI=1S/C20H21ClN2O4S/c1-20(2,19(24)25)27-11-14-8-17(18-9-15(26-3)12-28-18)23(22-14)10-13-6-4-5-7-16(13)21/h4-9,12H,10-11H2,1-3H3,(H,24,25)
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US Patent


Assay Description
MDA-MB-231 breast cancer cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known to ...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345318
PNG
(US10202350, Example 64)
Show SMILES COc1ccc(s1)-c1cc(COC(C)(C)C(O)=O)nn1Cc1ccccc1Cl
Show InChI InChI=1S/C20H21ClN2O4S/c1-20(2,19(24)25)27-12-14-10-16(17-8-9-18(26-3)28-17)23(22-14)11-13-6-4-5-7-15(13)21/h4-10H,11-12H2,1-3H3,(H,24,25)
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US Patent


Assay Description
MDA-MB-231 breast cancer cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known to ...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345284
PNG
(2-[[1-[(2-Bromophenyl)methyl]-5-(3- methoxyphenyl...)
Show SMILES COc1cccc(c1)-c1cc(COC(C)(C)C(O)=O)nn1Cc1ccccc1Br
Show InChI InChI=1S/C22H23BrN2O4/c1-22(2,21(26)27)29-14-17-12-20(15-8-6-9-18(11-15)28-3)25(24-17)13-16-7-4-5-10-19(16)23/h4-12H,13-14H2,1-3H3,(H,26,27)
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US Patent


Assay Description
MDA-MB-231 breast cancer cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known to ...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345322
PNG
(2-([1-[(2-Chlorophenyl)methyl]-5-(3-methoxyphenyl)...)
Show SMILES CCC(C)(OCc1cc(-c2cccc(OC)c2)n(Cc2ccccc2Cl)n1)C(O)=O
Show InChI InChI=1S/C23H25ClN2O4/c1-4-23(2,22(27)28)30-15-18-13-21(16-9-7-10-19(12-16)29-3)26(25-18)14-17-8-5-6-11-20(17)24/h5-13H,4,14-15H2,1-3H3,(H,27,28)
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US Patent


Assay Description
MDA-MB-231 breast cancer cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known to ...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345288
PNG
(2-[[1-[(2-Chlorophenyl)methyl]-5-[3- (trifluorome...)
Show SMILES CC(C)(OCc1cc(-c2cccc(OC(F)(F)F)c2)n(Cc2ccccc2Cl)n1)C(O)=O
Show InChI InChI=1S/C22H20ClF3N2O4/c1-21(2,20(29)30)31-13-16-11-19(14-7-5-8-17(10-14)32-22(24,25)26)28(27-16)12-15-6-3-4-9-18(15)23/h3-11H,12-13H2,1-2H3,(H,29,30)
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Assay Description
MDA-MB-231 breast cancer cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known to ...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345280
PNG
(2-[[1-[(2-Fluorophenyl)methyl]-5-(3- isobutoxyphe...)
Show SMILES CC(C)COc1cccc(c1)-c1cc(COC(C)(C)C(O)=O)nn1Cc1ccccc1F
Show InChI InChI=1S/C25H29FN2O4/c1-17(2)15-31-21-10-7-9-18(12-21)23-13-20(16-32-25(3,4)24(29)30)27-28(23)14-19-8-5-6-11-22(19)26/h5-13,17H,14-16H2,1-4H3,(H,29,30)
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Assay Description
MDA-MB-231 breast cancer cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known to ...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345321
PNG
(2-([1-(o-Chlorophenyl)methyl]-5-(m-methoxyphenyl)-...)
Show SMILES CCC(CC)(OCc1cc(-c2cccc(OC)c2)n(Cc2ccccc2Cl)n1)C(O)=O
Show InChI InChI=1S/C24H27ClN2O4/c1-4-24(5-2,23(28)29)31-16-19-14-22(17-10-8-11-20(13-17)30-3)27(26-19)15-18-9-6-7-12-21(18)25/h6-14H,4-5,15-16H2,1-3H3,(H,28,29)
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Assay Description
MDA-MB-231 breast cancer cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known to ...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345282
PNG
(2-[[1-[(2-Chlorophenyl)methyl]-5-(3- ethoxyphenyl...)
Show SMILES CCOc1cccc(c1)-c1cc(COC(C)(C)C(O)=O)nn1Cc1ccccc1Cl
Show InChI InChI=1S/C23H25ClN2O4/c1-4-29-19-10-7-9-16(12-19)21-13-18(15-30-23(2,3)22(27)28)25-26(21)14-17-8-5-6-11-20(17)24/h5-13H,4,14-15H2,1-3H3,(H,27,28)
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US Patent


Assay Description
MDA-MB-231 breast cancer cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known to ...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345297
PNG
(2-[[1-[(2-Chlorophenyl)methyl]-5-[3- (2,2,2-trifl...)
Show SMILES CC(C)(OCc1cc(-c2cccc(OCC(F)(F)F)c2)n(Cc2ccccc2Cl)n1)C(O)=O
Show InChI InChI=1S/C23H22ClF3N2O4/c1-22(2,21(30)31)33-13-17-11-20(29(28-17)12-16-6-3-4-9-19(16)24)15-7-5-8-18(10-15)32-14-23(25,26)27/h3-11H,12-14H2,1-2H3,(H,30,31)
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US Patent


Assay Description
MDA-MB-231 breast cancer cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known to ...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345314
PNG
(US10202350, Example 60)
Show SMILES CC(C)COc1cccc(c1)-c1cc(COC(C)(C)C(O)=O)nn1Cc1ccccc1
Show InChI InChI=1S/C25H30N2O4/c1-18(2)16-30-22-12-8-11-20(13-22)23-14-21(17-31-25(3,4)24(28)29)26-27(23)15-19-9-6-5-7-10-19/h5-14,18H,15-17H2,1-4H3,(H,28,29)
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US Patent


Assay Description
MDA-MB-231 breast cancer cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known to ...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345305
PNG
(US10202350, Example 51)
Show SMILES CC(C)c1cccc(c1)-c1cc(COC(C)(C)C(O)=O)nn1Cc1ccccc1Cl
Show InChI InChI=1S/C24H27ClN2O3/c1-16(2)17-9-7-10-18(12-17)22-13-20(15-30-24(3,4)23(28)29)26-27(22)14-19-8-5-6-11-21(19)25/h5-13,16H,14-15H2,1-4H3,(H,28,29)
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US Patent


Assay Description
MDA-MB-231 breast cancer cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known to ...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345299
PNG
(2-[[1-[(2-Chlorophenyl)methyl]-5-[3- (tetrahydrop...)
Show SMILES CC(C)(OCc1cc(-c2cccc(OCC3CCOCC3)c2)n(Cc2ccccc2Cl)n1)C(O)=O
Show InChI InChI=1S/C27H31ClN2O5/c1-27(2,26(31)32)35-18-22-15-25(30(29-22)16-21-6-3-4-9-24(21)28)20-7-5-8-23(14-20)34-17-19-10-12-33-13-11-19/h3-9,14-15,19H,10-13,16-18H2,1-2H3,(H,31,32)
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Vettore, LLC

US Patent


Assay Description
MDA-MB-231 breast cancer cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known to ...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345267
PNG
(2-[[1-[(2-Chlorophenyl)methyl]-5-[3- (trifluorome...)
Show SMILES CC(C)(OCc1cc(-c2cccc(c2)C(F)(F)F)n(Cc2ccccc2Cl)n1)C(O)=O
Show InChI InChI=1S/C22H20ClF3N2O3/c1-21(2,20(29)30)31-13-17-11-19(14-7-5-8-16(10-14)22(24,25)26)28(27-17)12-15-6-3-4-9-18(15)23/h3-11H,12-13H2,1-2H3,(H,29,30)
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Vettore, LLC

US Patent


Assay Description
MCT4 may be stably expressed in MDA-MB-453 breast cancer cells that do not express native MCT1 or MCT4. MCT4 activity may be assessed by monitoring t...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345264
PNG
(2-[[5-(3-Chlorophenyl)-1-[(2- chlorophenyl)methyl...)
Show SMILES CC(C)(OCc1cc(-c2cccc(Cl)c2)n(Cc2ccccc2Cl)n1)C(O)=O
Show InChI InChI=1S/C21H20Cl2N2O3/c1-21(2,20(26)27)28-13-17-11-19(14-7-5-8-16(22)10-14)25(24-17)12-15-6-3-4-9-18(15)23/h3-11H,12-13H2,1-2H3,(H,26,27)
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Vettore, LLC

US Patent


Assay Description
MCT4 may be stably expressed in MDA-MB-453 breast cancer cells that do not express native MCT1 or MCT4. MCT4 activity may be assessed by monitoring t...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345327
PNG
(2-([1-[(2-chlorophenyl)methyl]-5-[3-[(2-methylprop...)
Show SMILES CC(C)CNc1cccc(c1)-c1cc(COC(C)(C)C(O)=O)nn1Cc1ccccc1Cl
Show InChI InChI=1S/C25H30ClN3O3/c1-17(2)14-27-20-10-7-9-18(12-20)23-13-21(16-32-25(3,4)24(30)31)28-29(23)15-19-8-5-6-11-22(19)26/h5-13,17,27H,14-16H2,1-4H3,(H,30,31)
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Vettore, LLC

US Patent


Assay Description
MDA-MB-231 breast cancer cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known to ...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345267
PNG
(2-[[1-[(2-Chlorophenyl)methyl]-5-[3- (trifluorome...)
Show SMILES CC(C)(OCc1cc(-c2cccc(c2)C(F)(F)F)n(Cc2ccccc2Cl)n1)C(O)=O
Show InChI InChI=1S/C22H20ClF3N2O3/c1-21(2,20(29)30)31-13-17-11-19(14-7-5-8-16(10-14)22(24,25)26)28(27-17)12-15-6-3-4-9-18(15)23/h3-11H,12-13H2,1-2H3,(H,29,30)
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Vettore, LLC

US Patent


Assay Description
NCI-H358 lung adenocarcinoma cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345265
PNG
(2-[[1-[(2-Chlorophenyl)methyl]-5-(m- tolyl)pyrazo...)
Show SMILES Cc1cccc(c1)-c1cc(COC(C)(C)C(O)=O)nn1Cc1ccccc1Cl
Show InChI InChI=1S/C22H23ClN2O3/c1-15-7-6-9-16(11-15)20-12-18(14-28-22(2,3)21(26)27)24-25(20)13-17-8-4-5-10-19(17)23/h4-12H,13-14H2,1-3H3,(H,26,27)
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Vettore, LLC

US Patent


Assay Description
NCI-H358 lung adenocarcinoma cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345268
PNG
(2-[[1-[(2-Chlorophenyl)methyl]-5-(3- methoxypheny...)
Show SMILES COc1cccc(c1)-c1cc(COC(C)(C)C(O)=O)nn1Cc1ccccc1Cl
Show InChI InChI=1S/C22H23ClN2O4/c1-22(2,21(26)27)29-14-17-12-20(15-8-6-9-18(11-15)28-3)25(24-17)13-16-7-4-5-10-19(16)23/h4-12H,13-14H2,1-3H3,(H,26,27)
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Vettore, LLC

US Patent


Assay Description
MCT4 may be stably expressed in MDA-MB-453 breast cancer cells that do not express native MCT1 or MCT4. MCT4 activity may be assessed by monitoring t...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345268
PNG
(2-[[1-[(2-Chlorophenyl)methyl]-5-(3- methoxypheny...)
Show SMILES COc1cccc(c1)-c1cc(COC(C)(C)C(O)=O)nn1Cc1ccccc1Cl
Show InChI InChI=1S/C22H23ClN2O4/c1-22(2,21(26)27)29-14-17-12-20(15-8-6-9-18(11-15)28-3)25(24-17)13-16-7-4-5-10-19(16)23/h4-12H,13-14H2,1-3H3,(H,26,27)
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Vettore, LLC

US Patent


Assay Description
MDA-MB-231 breast cancer cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known to ...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345278
PNG
(2-[[1-[(2-Chlorophenyl)methyl]-5-(3- thienyl)pyra...)
Show SMILES CC(C)(OCc1cc(-c2ccsc2)n(Cc2ccccc2Cl)n1)C(O)=O
Show InChI InChI=1S/C19H19ClN2O3S/c1-19(2,18(23)24)25-11-15-9-17(14-7-8-26-12-14)22(21-15)10-13-5-3-4-6-16(13)20/h3-9,12H,10-11H2,1-2H3,(H,23,24)
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Vettore, LLC

US Patent


Assay Description
MDA-MB-231 breast cancer cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known to ...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345264
PNG
(2-[[5-(3-Chlorophenyl)-1-[(2- chlorophenyl)methyl...)
Show SMILES CC(C)(OCc1cc(-c2cccc(Cl)c2)n(Cc2ccccc2Cl)n1)C(O)=O
Show InChI InChI=1S/C21H20Cl2N2O3/c1-21(2,20(26)27)28-13-17-11-19(14-7-5-8-16(22)10-14)25(24-17)12-15-6-3-4-9-18(15)23/h3-11H,12-13H2,1-2H3,(H,26,27)
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Vettore, LLC

US Patent


Assay Description
NCI-H358 lung adenocarcinoma cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345279
PNG
(2-[[1-[(2-Chlorophenyl)methyl]-5-(2- thienyl)pyra...)
Show SMILES CC(C)(OCc1cc(-c2cccs2)n(Cc2ccccc2Cl)n1)C(O)=O
Show InChI InChI=1S/C19H19ClN2O3S/c1-19(2,18(23)24)25-12-14-10-16(17-8-5-9-26-17)22(21-14)11-13-6-3-4-7-15(13)20/h3-10H,11-12H2,1-2H3,(H,23,24)
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Vettore, LLC

US Patent


Assay Description
MDA-MB-231 breast cancer cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known to ...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345316
PNG
(2-([1-[(3-methoxyphenyl)methyl]-5-[3-(2- methylpr...)
Show SMILES COc1cccc(Cn2nc(COC(C)(C)C(O)=O)cc2-c2cccc(OCC(C)C)c2)c1
Show InChI InChI=1S/C26H32N2O5/c1-18(2)16-32-23-11-7-9-20(13-23)24-14-21(17-33-26(3,4)25(29)30)27-28(24)15-19-8-6-10-22(12-19)31-5/h6-14,18H,15-17H2,1-5H3,(H,29,30)
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Vettore, LLC

US Patent


Assay Description
MDA-MB-231 breast cancer cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known to ...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345308
PNG
(2-({1-[(o-Chlorophenyl)methyl]-5-(m- methoxypheny...)
Show SMILES COc1cccc(c1)-c1c(C)c(COC(C)(C)C(O)=O)nn1Cc1ccccc1Cl
Show InChI InChI=1S/C23H25ClN2O4/c1-15-20(14-30-23(2,3)22(27)28)25-26(13-17-8-5-6-11-19(17)24)21(15)16-9-7-10-18(12-16)29-4/h5-12H,13-14H2,1-4H3,(H,27,28)
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Vettore, LLC

US Patent


Assay Description
MDA-MB-231 breast cancer cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known to ...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345317
PNG
(2-([1-[(4-methoxyphenyl)methyl]-5-[3-(2- methylpr...)
Show SMILES COc1ccc(Cn2nc(COC(C)(C)C(O)=O)cc2-c2cccc(OCC(C)C)c2)cc1
Show InChI InChI=1S/C26H32N2O5/c1-18(2)16-32-23-8-6-7-20(13-23)24-14-21(17-33-26(3,4)25(29)30)27-28(24)15-19-9-11-22(31-5)12-10-19/h6-14,18H,15-17H2,1-5H3,(H,29,30)
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Vettore, LLC

US Patent


Assay Description
MDA-MB-231 breast cancer cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known to ...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345266
PNG
(2-[[1-[(2-Chlorophenyl)methyl]-5-(3- fluorophenyl...)
Show SMILES CC(C)(OCc1cc(-c2cccc(F)c2)n(Cc2ccccc2Cl)n1)C(O)=O
Show InChI InChI=1S/C21H20ClFN2O3/c1-21(2,20(26)27)28-13-17-11-19(14-7-5-8-16(23)10-14)25(24-17)12-15-6-3-4-9-18(15)22/h3-11H,12-13H2,1-2H3,(H,26,27)
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Vettore, LLC

US Patent


Assay Description
MCT4 may be stably expressed in MDA-MB-453 breast cancer cells that do not express native MCT1 or MCT4. MCT4 activity may be assessed by monitoring t...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345268
PNG
(2-[[1-[(2-Chlorophenyl)methyl]-5-(3- methoxypheny...)
Show SMILES COc1cccc(c1)-c1cc(COC(C)(C)C(O)=O)nn1Cc1ccccc1Cl
Show InChI InChI=1S/C22H23ClN2O4/c1-22(2,21(26)27)29-14-17-12-20(15-8-6-9-18(11-15)28-3)25(24-17)13-16-7-4-5-10-19(16)23/h4-12H,13-14H2,1-3H3,(H,26,27)
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Vettore, LLC

US Patent


Assay Description
NCI-H358 lung adenocarcinoma cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345265
PNG
(2-[[1-[(2-Chlorophenyl)methyl]-5-(m- tolyl)pyrazo...)
Show SMILES Cc1cccc(c1)-c1cc(COC(C)(C)C(O)=O)nn1Cc1ccccc1Cl
Show InChI InChI=1S/C22H23ClN2O3/c1-15-7-6-9-16(11-15)20-12-18(14-28-22(2,3)21(26)27)24-25(20)13-17-8-4-5-10-19(17)23/h4-12H,13-14H2,1-3H3,(H,26,27)
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Vettore, LLC

US Patent


Assay Description
MCT4 may be stably expressed in MDA-MB-453 breast cancer cells that do not express native MCT1 or MCT4. MCT4 activity may be assessed by monitoring t...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345292
PNG
(2-[[1-[[2-(Dimethylamino)phenyl]methyl]- 5-(3-met...)
Show SMILES COc1cccc(c1)-c1cc(COC(C)(C)C(O)=O)nn1Cc1ccccc1N(C)C
Show InChI InChI=1S/C24H29N3O4/c1-24(2,23(28)29)31-16-19-14-22(17-10-8-11-20(13-17)30-5)27(25-19)15-18-9-6-7-12-21(18)26(3)4/h6-14H,15-16H2,1-5H3,(H,28,29)
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Vettore, LLC

US Patent


Assay Description
MDA-MB-231 breast cancer cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known to ...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345266
PNG
(2-[[1-[(2-Chlorophenyl)methyl]-5-(3- fluorophenyl...)
Show SMILES CC(C)(OCc1cc(-c2cccc(F)c2)n(Cc2ccccc2Cl)n1)C(O)=O
Show InChI InChI=1S/C21H20ClFN2O3/c1-21(2,20(26)27)28-13-17-11-19(14-7-5-8-16(23)10-14)25(24-17)12-15-6-3-4-9-18(15)22/h3-11H,12-13H2,1-2H3,(H,26,27)
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Vettore, LLC

US Patent


Assay Description
NCI-H358 lung adenocarcinoma cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345277
PNG
(2-[[5-(4-Chlorophenyl)-1-(3- pyridylmethyl)pyrazo...)
Show SMILES CC(C)(OCc1cc(-c2ccc(Cl)cc2)n(Cc2cccnc2)n1)C(O)=O
Show InChI InChI=1S/C20H20ClN3O3/c1-20(2,19(25)26)27-13-17-10-18(15-5-7-16(21)8-6-15)24(23-17)12-14-4-3-9-22-11-14/h3-11H,12-13H2,1-2H3,(H,25,26)
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Vettore, LLC

US Patent


Assay Description
NCI-H358 lung adenocarcinoma cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345285
PNG
(2-[[1-[(2-Isopropylphenyl)methyl]-5-(3- methoxyph...)
Show SMILES COc1cccc(c1)-c1cc(COC(C)(C)C(O)=O)nn1Cc1ccccc1C(C)C
Show InChI InChI=1S/C25H30N2O4/c1-17(2)22-12-7-6-9-19(22)15-27-23(18-10-8-11-21(13-18)30-5)14-20(26-27)16-31-25(3,4)24(28)29/h6-14,17H,15-16H2,1-5H3,(H,28,29)
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Vettore, LLC

US Patent


Assay Description
MDA-MB-231 breast cancer cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known to ...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345258
PNG
(2-[[1-[(2-Chlorophenyl)methyl]-5-(4- fluorophenyl...)
Show SMILES CC(C)(OCc1cc(-c2ccc(F)cc2)n(Cc2ccccc2Cl)n1)C(O)=O
Show InChI InChI=1S/C21H20ClFN2O3/c1-21(2,20(26)27)28-13-17-11-19(14-7-9-16(23)10-8-14)25(24-17)12-15-5-3-4-6-18(15)22/h3-11H,12-13H2,1-2H3,(H,26,27)
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Vettore, LLC

US Patent


Assay Description
NCI-H358 lung adenocarcinoma cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345287
PNG
(2-[[1-[(2-Chlorophenyl)methyl]-5-[3- (cyclopropyl...)
Show SMILES CC(C)(OCc1cc(-c2cccc(OCC3CC3)c2)n(Cc2ccccc2Cl)n1)C(O)=O
Show InChI InChI=1S/C25H27ClN2O4/c1-25(2,24(29)30)32-16-20-13-23(28(27-20)14-19-6-3-4-9-22(19)26)18-7-5-8-21(12-18)31-15-17-10-11-17/h3-9,12-13,17H,10-11,14-16H2,1-2H3,(H,29,30)
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Vettore, LLC

US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345295
PNG
(1-[[1-[(2-Chlorophenyl)methyl]-5-(3- methoxypheny...)
Show SMILES COc1cccc(c1)-c1cc(COC2(CCC2)C(O)=O)nn1Cc1ccccc1Cl
Show InChI InChI=1S/C23H23ClN2O4/c1-29-19-8-4-7-16(12-19)21-13-18(15-30-23(22(27)28)10-5-11-23)25-26(21)14-17-6-2-3-9-20(17)24/h2-4,6-9,12-13H,5,10-11,14-15H2,1H3,(H,27,28)
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Vettore, LLC

US Patent


Assay Description
MDA-MB-231 breast cancer cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known to ...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345332
PNG
(2-[[1-[(2-Chlorophenyl)methyl]-5-(3-hydroxyphenyl)...)
Show SMILES CC(C)(OCc1cc(-c2cccc(O)c2)n(Cc2ccccc2Cl)n1)C(O)=O
Show InChI InChI=1S/C21H21ClN2O4/c1-21(2,20(26)27)28-13-16-11-19(14-7-5-8-17(25)10-14)24(23-16)12-15-6-3-4-9-18(15)22/h3-11,25H,12-13H2,1-2H3,(H,26,27)
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Vettore, LLC

US Patent


Assay Description
MDA-MB-231 breast cancer cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known to ...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345257
PNG
(2-[[5-(4-Chlorophenyl)-1-[(2- chlorophenyl)methyl...)
Show SMILES CC(C)(OCc1cc(-c2ccc(Cl)cc2)n(Cc2ccccc2Cl)n1)C(O)=O
Show InChI InChI=1S/C21H20Cl2N2O3/c1-21(2,20(26)27)28-13-17-11-19(14-7-9-16(22)10-8-14)25(24-17)12-15-5-3-4-6-18(15)23/h3-11H,12-13H2,1-2H3,(H,26,27)
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Vettore, LLC

US Patent


Assay Description
NCI-H358 lung adenocarcinoma cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345259
PNG
(2-[[5-(4-Chlorophenyl)-1-[(2,4- dichlorophenyl)me...)
Show SMILES CC(C)(OCc1cc(-c2ccc(Cl)cc2)n(Cc2ccc(Cl)cc2Cl)n1)C(O)=O
Show InChI InChI=1S/C21H19Cl3N2O3/c1-21(2,20(27)28)29-12-17-10-19(13-3-6-15(22)7-4-13)26(25-17)11-14-5-8-16(23)9-18(14)24/h3-10H,11-12H2,1-2H3,(H,27,28)
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Vettore, LLC

US Patent


Assay Description
NCI-H358 lung adenocarcinoma cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345258
PNG
(2-[[1-[(2-Chlorophenyl)methyl]-5-(4- fluorophenyl...)
Show SMILES CC(C)(OCc1cc(-c2ccc(F)cc2)n(Cc2ccccc2Cl)n1)C(O)=O
Show InChI InChI=1S/C21H20ClFN2O3/c1-21(2,20(26)27)28-13-17-11-19(14-7-9-16(23)10-8-14)25(24-17)12-15-5-3-4-6-18(15)22/h3-11H,12-13H2,1-2H3,(H,26,27)
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Vettore, LLC

US Patent


Assay Description
MCT4 may be stably expressed in MDA-MB-453 breast cancer cells that do not express native MCT1 or MCT4. MCT4 activity may be assessed by monitoring t...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345262
PNG
(2-[[1-[(2-Chlorophenyl)methyl]-5-phenyl- pyrazol-...)
Show SMILES CC(C)(OCc1cc(-c2ccccc2)n(Cc2ccccc2Cl)n1)C(O)=O
Show InChI InChI=1S/C21H21ClN2O3/c1-21(2,20(25)26)27-14-17-12-19(15-8-4-3-5-9-15)24(23-17)13-16-10-6-7-11-18(16)22/h3-12H,13-14H2,1-2H3,(H,25,26)
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Vettore, LLC

US Patent


Assay Description
MCT4 may be stably expressed in MDA-MB-453 breast cancer cells that do not express native MCT1 or MCT4. MCT4 activity may be assessed by monitoring t...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345304
PNG
(2-([1-[(o-Chlorophenyl)methyl]-5-[m- (dimethylami...)
Show SMILES CN(C)c1cccc(c1)-c1cc(COC(C)(C)C(O)=O)nn1Cc1ccccc1Cl
Show InChI InChI=1S/C23H26ClN3O3/c1-23(2,22(28)29)30-15-18-13-21(16-9-7-10-19(12-16)26(3)4)27(25-18)14-17-8-5-6-11-20(17)24/h5-13H,14-15H2,1-4H3,(H,28,29)
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Vettore, LLC

US Patent


Assay Description
MDA-MB-231 breast cancer cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known to ...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345257
PNG
(2-[[5-(4-Chlorophenyl)-1-[(2- chlorophenyl)methyl...)
Show SMILES CC(C)(OCc1cc(-c2ccc(Cl)cc2)n(Cc2ccccc2Cl)n1)C(O)=O
Show InChI InChI=1S/C21H20Cl2N2O3/c1-21(2,20(26)27)28-13-17-11-19(14-7-9-16(22)10-8-14)25(24-17)12-15-5-3-4-6-18(15)23/h3-11H,12-13H2,1-2H3,(H,26,27)
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Vettore, LLC

US Patent


Assay Description
MCT4 may be stably expressed in MDA-MB-453 breast cancer cells that do not express native MCT1 or MCT4. MCT4 activity may be assessed by monitoring t...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345286
PNG
(2-[[5-(3-Methoxyphenyl)-1-(o- tolylmethyl)pyrazol...)
Show SMILES COc1cccc(c1)-c1cc(COC(C)(C)C(O)=O)nn1Cc1ccccc1C
Show InChI InChI=1S/C23H26N2O4/c1-16-8-5-6-9-18(16)14-25-21(17-10-7-11-20(12-17)28-4)13-19(24-25)15-29-23(2,3)22(26)27/h5-13H,14-15H2,1-4H3,(H,26,27)
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Vettore, LLC

US Patent


Assay Description
MDA-MB-231 breast cancer cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known to ...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345333
PNG
(US10202350, Example 80)
Show SMILES CC(C)(OCc1cc(-c2cccc(OCC3COC3)c2)n(Cc2ccccc2Cl)n1)C(O)=O
Show InChI InChI=1S/C25H27ClN2O5/c1-25(2,24(29)30)33-16-20-11-23(28(27-20)12-19-6-3-4-9-22(19)26)18-7-5-8-21(10-18)32-15-17-13-31-14-17/h3-11,17H,12-16H2,1-2H3,(H,29,30)
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Vettore, LLC

US Patent


Assay Description
MDA-MB-231 breast cancer cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known to ...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345262
PNG
(2-[[1-[(2-Chlorophenyl)methyl]-5-phenyl- pyrazol-...)
Show SMILES CC(C)(OCc1cc(-c2ccccc2)n(Cc2ccccc2Cl)n1)C(O)=O
Show InChI InChI=1S/C21H21ClN2O3/c1-21(2,20(25)26)27-14-17-12-19(15-8-4-3-5-9-15)24(23-17)13-16-10-6-7-11-18(16)22/h3-12H,13-14H2,1-2H3,(H,25,26)
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Vettore, LLC

US Patent


Assay Description
NCI-H358 lung adenocarcinoma cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345290
PNG
(2-[[5-(3-Methoxyphenyl)-1-[(2- methoxyphenyl)meth...)
Show SMILES COc1cccc(c1)-c1cc(COC(C)(C)C(O)=O)nn1Cc1ccccc1OC
Show InChI InChI=1S/C23H26N2O5/c1-23(2,22(26)27)30-15-18-13-20(16-9-7-10-19(12-16)28-3)25(24-18)14-17-8-5-6-11-21(17)29-4/h5-13H,14-15H2,1-4H3,(H,26,27)
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Vettore, LLC

US Patent


Assay Description
MDA-MB-231 breast cancer cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known to ...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345302
PNG
(2-([1-[(o-Chlorophenyl)methyl]-5-(m- cyanophenyl)...)
Show SMILES CC(C)(OCc1cc(-c2cccc(c2)C#N)n(Cc2ccccc2Cl)n1)C(O)=O
Show InChI InChI=1S/C22H20ClN3O3/c1-22(2,21(27)28)29-14-18-11-20(16-8-5-6-15(10-16)12-24)26(25-18)13-17-7-3-4-9-19(17)23/h3-11H,13-14H2,1-2H3,(H,27,28)
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Vettore, LLC

US Patent


Assay Description
MDA-MB-231 breast cancer cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known to ...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345295
PNG
(1-[[1-[(2-Chlorophenyl)methyl]-5-(3- methoxypheny...)
Show SMILES COc1cccc(c1)-c1cc(COC2(CCC2)C(O)=O)nn1Cc1ccccc1Cl
Show InChI InChI=1S/C23H23ClN2O4/c1-29-19-8-4-7-16(12-19)21-13-18(15-30-23(22(27)28)10-5-11-23)25-26(21)14-17-6-2-3-9-20(17)24/h2-4,6-9,12-13H,5,10-11,14-15H2,1H3,(H,27,28)
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Vettore, LLC

US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345271
PNG
(1-[[5-(4-Chlorophenyl)-1-[(2- chlorophenyl)methyl...)
Show SMILES OC(=O)C1(CC1)OCc1cc(-c2ccc(Cl)cc2)n(Cc2ccccc2Cl)n1
Show InChI InChI=1S/C21H18Cl2N2O3/c22-16-7-5-14(6-8-16)19-11-17(13-28-21(9-10-21)20(26)27)24-25(19)12-15-3-1-2-4-18(15)23/h1-8,11H,9-10,12-13H2,(H,26,27)
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Vettore, LLC

US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345272
PNG
(2-[[1-[(2-Chlorophenyl)methyl]-5-thiazol- 2-yl-py...)
Show SMILES CC(C)(OCc1cc(-c2nccs2)n(Cc2ccccc2Cl)n1)C(O)=O
Show InChI InChI=1S/C18H18ClN3O3S/c1-18(2,17(23)24)25-11-13-9-15(16-20-7-8-26-16)22(21-13)10-12-5-3-4-6-14(12)19/h3-9H,10-11H2,1-2H3,(H,23,24)
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Vettore, LLC

US Patent


Assay Description
NCI-H358 lung adenocarcinoma cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345311
PNG
(2-[[1-(2-chlorophenyl)-5-(3-methoxyphenyl)- 1H-py...)
Show SMILES COc1cccc(c1)-c1cc(COC(C)(C)C(O)=O)nn1-c1ccccc1Cl
Show InChI InChI=1S/C21H21ClN2O4/c1-21(2,20(25)26)28-13-15-12-19(14-7-6-8-16(11-14)27-3)24(23-15)18-10-5-4-9-17(18)22/h4-12H,13H2,1-3H3,(H,25,26)
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Vettore, LLC

US Patent


Assay Description
MDA-MB-231 breast cancer cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known to ...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345273
PNG
(2-[[5-(4-Chlorophenyl)-1-[(2- fluorophenyl)methyl...)
Show SMILES CC(C)(OCc1cc(-c2ccc(Cl)cc2)n(Cc2ccccc2F)n1)C(O)=O
Show InChI InChI=1S/C21H20ClFN2O3/c1-21(2,20(26)27)28-13-17-11-19(14-7-9-16(22)10-8-14)25(24-17)12-15-5-3-4-6-18(15)23/h3-11H,12-13H2,1-2H3,(H,26,27)
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Vettore, LLC

US Patent


Assay Description
MCT4 may be stably expressed in MDA-MB-453 breast cancer cells that do not express native MCT1 or MCT4. MCT4 activity may be assessed by monitoring t...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345255
PNG
(US10202350, Example 1)
Show SMILES CC(C)(OCc1cc(-c2ccccc2)n(Cc2cccc(Cl)c2)n1)C(O)=O
Show InChI InChI=1S/C21H21ClN2O3/c1-21(2,20(25)26)27-14-18-12-19(16-8-4-3-5-9-16)24(23-18)13-15-7-6-10-17(22)11-15/h3-12H,13-14H2,1-2H3,(H,25,26)
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Vettore, LLC

US Patent


Assay Description
NCI-H358 lung adenocarcinoma cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345300
PNG
(2-[[1-[(2-Chlorophenyl)methyl]-5-(3- morpholinoph...)
Show SMILES CC(C)(OCc1cc(-c2cccc(c2)N2CCOCC2)n(Cc2ccccc2Cl)n1)C(O)=O
Show InChI InChI=1S/C25H28ClN3O4/c1-25(2,24(30)31)33-17-20-15-23(29(27-20)16-19-6-3-4-9-22(19)26)18-7-5-8-21(14-18)28-10-12-32-13-11-28/h3-9,14-15H,10-13,16-17H2,1-2H3,(H,30,31)
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US Patent


Assay Description
MDA-MB-231 breast cancer cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known to ...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345312
PNG
(2-[[1-(3-chlorophenyl)-5-(3-methoxyphenyl)- 1H-py...)
Show SMILES COc1cccc(c1)-c1cc(COC(C)(C)C(O)=O)nn1-c1cccc(Cl)c1
Show InChI InChI=1S/C21H21ClN2O4/c1-21(2,20(25)26)28-13-16-12-19(14-6-4-9-18(10-14)27-3)24(23-16)17-8-5-7-15(22)11-17/h4-12H,13H2,1-3H3,(H,25,26)
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US Patent


Assay Description
MDA-MB-231 breast cancer cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known to ...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345272
PNG
(2-[[1-[(2-Chlorophenyl)methyl]-5-thiazol- 2-yl-py...)
Show SMILES CC(C)(OCc1cc(-c2nccs2)n(Cc2ccccc2Cl)n1)C(O)=O
Show InChI InChI=1S/C18H18ClN3O3S/c1-18(2,17(23)24)25-11-13-9-15(16-20-7-8-26-16)22(21-13)10-12-5-3-4-6-14(12)19/h3-9H,10-11H2,1-2H3,(H,23,24)
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Vettore, LLC

US Patent


Assay Description
MCT4 may be stably expressed in MDA-MB-453 breast cancer cells that do not express native MCT1 or MCT4. MCT4 activity may be assessed by monitoring t...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345334
PNG
(US10202350, Example 81)
Show SMILES COc1cccc(c1)-c1cc(COC(C)(C)C(=O)NS(C)(=O)=O)nn1Cc1ccccc1Cl
Show InChI InChI=1S/C23H26ClN3O5S/c1-23(2,22(28)26-33(4,29)30)32-15-18-13-21(16-9-7-10-19(12-16)31-3)27(25-18)14-17-8-5-6-11-20(17)24/h5-13H,14-15H2,1-4H3,(H,26,28)
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Vettore, LLC

US Patent


Assay Description
MDA-MB-231 breast cancer cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known to ...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345324
PNG
(US10202350, Example 70)
Show SMILES CC(C)(OCc1cc(-c2cccc(c2)S(C)(=O)=O)n(Cc2ccccc2Cl)n1)C(O)=O
Show InChI InChI=1S/C22H23ClN2O5S/c1-22(2,21(26)27)30-14-17-12-20(15-8-6-9-18(11-15)31(3,28)29)25(24-17)13-16-7-4-5-10-19(16)23/h4-12H,13-14H2,1-3H3,(H,26,27)
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Vettore, LLC

US Patent


Assay Description
MDA-MB-231 breast cancer cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known to ...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345307
PNG
(2-[[1-benzyl-5-(3-methoxyphenyl)-1H- pyrazol-3-yl...)
Show SMILES COc1cccc(c1)-c1cc(COC(C)(C)C(O)=O)nn1Cc1ccccc1
Show InChI InChI=1S/C22H24N2O4/c1-22(2,21(25)26)28-15-18-13-20(17-10-7-11-19(12-17)27-3)24(23-18)14-16-8-5-4-6-9-16/h4-13H,14-15H2,1-3H3,(H,25,26)
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Vettore, LLC

US Patent


Assay Description
MDA-MB-231 breast cancer cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known to ...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345259
PNG
(2-[[5-(4-Chlorophenyl)-1-[(2,4- dichlorophenyl)me...)
Show SMILES CC(C)(OCc1cc(-c2ccc(Cl)cc2)n(Cc2ccc(Cl)cc2Cl)n1)C(O)=O
Show InChI InChI=1S/C21H19Cl3N2O3/c1-21(2,20(27)28)29-12-17-10-19(13-3-6-15(22)7-4-13)26(25-17)11-14-5-8-16(23)9-18(14)24/h3-10H,11-12H2,1-2H3,(H,27,28)
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Vettore, LLC

US Patent


Assay Description
MCT4 may be stably expressed in MDA-MB-453 breast cancer cells that do not express native MCT1 or MCT4. MCT4 activity may be assessed by monitoring t...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345273
PNG
(2-[[5-(4-Chlorophenyl)-1-[(2- fluorophenyl)methyl...)
Show SMILES CC(C)(OCc1cc(-c2ccc(Cl)cc2)n(Cc2ccccc2F)n1)C(O)=O
Show InChI InChI=1S/C21H20ClFN2O3/c1-21(2,20(26)27)28-13-17-11-19(14-7-9-16(22)10-8-14)25(24-17)12-15-5-3-4-6-18(15)23/h3-11H,12-13H2,1-2H3,(H,26,27)
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Vettore, LLC

US Patent


Assay Description
NCI-H358 lung adenocarcinoma cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345306
PNG
(2-([1-[(2-chlorophenyl)methyl]-5-[3- (methoxymethy...)
Show SMILES COCc1cccc(c1)-c1cc(COC(C)(C)C(O)=O)nn1Cc1ccccc1Cl
Show InChI InChI=1S/C23H25ClN2O4/c1-23(2,22(27)28)30-15-19-12-21(17-9-6-7-16(11-17)14-29-3)26(25-19)13-18-8-4-5-10-20(18)24/h4-12H,13-15H2,1-3H3,(H,27,28)
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Vettore, LLC

US Patent


Assay Description
MDA-MB-231 breast cancer cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known to ...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345260
PNG
(2-[[5-(4-Chlorophenyl)-1-[(2,4- dichlorophenyl)me...)
Show SMILES OC(=O)COCc1cc(-c2ccc(Cl)cc2)n(Cc2ccc(Cl)cc2Cl)n1
Show InChI InChI=1S/C19H15Cl3N2O3/c20-14-4-1-12(2-5-14)18-8-16(10-27-11-19(25)26)23-24(18)9-13-3-6-15(21)7-17(13)22/h1-8H,9-11H2,(H,25,26)
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Vettore, LLC

US Patent


Assay Description
MCT4 may be stably expressed in MDA-MB-453 breast cancer cells that do not express native MCT1 or MCT4. MCT4 activity may be assessed by monitoring t...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345328
PNG
(US10202350, Example 74)
Show SMILES CC(C)NC(=O)c1cccc(c1)-c1cc(COC(C)(C)C(O)=O)nn1Cc1ccccc1Cl
Show InChI InChI=1S/C25H28ClN3O4/c1-16(2)27-23(30)18-10-7-9-17(12-18)22-13-20(15-33-25(3,4)24(31)32)28-29(22)14-19-8-5-6-11-21(19)26/h5-13,16H,14-15H2,1-4H3,(H,27,30)(H,31,32)
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Vettore, LLC

US Patent


Assay Description
MDA-MB-231 breast cancer cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known to ...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345298
PNG
(2-[[1-[(2-Chlorophenyl)methyl]-5-[3- (cyclopentyl...)
Show SMILES CC(C)(OCc1cc(-c2cccc(OCC3CCCC3)c2)n(Cc2ccccc2Cl)n1)C(O)=O
Show InChI InChI=1S/C27H31ClN2O4/c1-27(2,26(31)32)34-18-22-15-25(30(29-22)16-21-10-5-6-13-24(21)28)20-11-7-12-23(14-20)33-17-19-8-3-4-9-19/h5-7,10-15,19H,3-4,8-9,16-18H2,1-2H3,(H,31,32)
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Vettore, LLC

US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345291
PNG
(2-[[1-[(2-Chlorophenyl)methyl]-5-[3- (cyclobutoxy...)
Show SMILES CC(C)(OCc1cc(-c2cccc(OC3CCC3)c2)n(Cc2ccccc2Cl)n1)C(O)=O
Show InChI InChI=1S/C25H27ClN2O4/c1-25(2,24(29)30)31-16-19-14-23(28(27-19)15-18-7-3-4-12-22(18)26)17-8-5-11-21(13-17)32-20-9-6-10-20/h3-5,7-8,11-14,20H,6,9-10,15-16H2,1-2H3,(H,29,30)
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Vettore, LLC

US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345326
PNG
(US10202350, Example 72)
Show SMILES CNc1cccc(c1)-c1cc(COC(C)(C)C(O)=O)nn1Cc1ccccc1Cl
Show InChI InChI=1S/C22H24ClN3O3/c1-22(2,21(27)28)29-14-18-12-20(15-8-6-9-17(11-15)24-3)26(25-18)13-16-7-4-5-10-19(16)23/h4-12,24H,13-14H2,1-3H3,(H,27,28)
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US Patent


Assay Description
MDA-MB-231 breast cancer cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known to ...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345303
PNG
(2-([1-[(o-Chlorophenyl)methyl]-5-(1,3- thiazol-5-...)
Show SMILES CC(C)(OCc1cc(-c2cncs2)n(Cc2ccccc2Cl)n1)C(O)=O
Show InChI InChI=1S/C18H18ClN3O3S/c1-18(2,17(23)24)25-10-13-7-15(16-8-20-11-26-16)22(21-13)9-12-5-3-4-6-14(12)19/h3-8,11H,9-10H2,1-2H3,(H,23,24)
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Vettore, LLC

US Patent


Assay Description
MDA-MB-231 breast cancer cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known to ...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345256
PNG
(2-[[5-(4-Chlorophenyl)-1-[(4- chlorophenyl)methyl...)
Show SMILES CC(C)(OCc1cc(-c2ccc(Cl)cc2)n(Cc2ccc(Cl)cc2)n1)C(O)=O
Show InChI InChI=1S/C21H20Cl2N2O3/c1-21(2,20(26)27)28-13-18-11-19(15-5-9-17(23)10-6-15)25(24-18)12-14-3-7-16(22)8-4-14/h3-11H,12-13H2,1-2H3,(H,26,27)
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Vettore, LLC

US Patent


Assay Description
NCI-H358 lung adenocarcinoma cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345277
PNG
(2-[[5-(4-Chlorophenyl)-1-(3- pyridylmethyl)pyrazo...)
Show SMILES CC(C)(OCc1cc(-c2ccc(Cl)cc2)n(Cc2cccnc2)n1)C(O)=O
Show InChI InChI=1S/C20H20ClN3O3/c1-20(2,19(25)26)27-13-17-10-18(15-5-7-16(21)8-6-15)24(23-17)12-14-4-3-9-22-11-14/h3-11H,12-13H2,1-2H3,(H,25,26)
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Vettore, LLC

US Patent


Assay Description
MCT4 may be stably expressed in MDA-MB-453 breast cancer cells that do not express native MCT1 or MCT4. MCT4 activity may be assessed by monitoring t...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345309
PNG
(2-[[5-(3-methoxyphenyl)-1-phenyl-1H- pyrazol-3-yl...)
Show SMILES COc1cccc(c1)-c1cc(COC(C)(C)C(O)=O)nn1-c1ccccc1
Show InChI InChI=1S/C21H22N2O4/c1-21(2,20(24)25)27-14-16-13-19(15-8-7-11-18(12-15)26-3)23(22-16)17-9-5-4-6-10-17/h4-13H,14H2,1-3H3,(H,24,25)
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Vettore, LLC

US Patent


Assay Description
MDA-MB-231 breast cancer cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known to ...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345260
PNG
(2-[[5-(4-Chlorophenyl)-1-[(2,4- dichlorophenyl)me...)
Show SMILES OC(=O)COCc1cc(-c2ccc(Cl)cc2)n(Cc2ccc(Cl)cc2Cl)n1
Show InChI InChI=1S/C19H15Cl3N2O3/c20-14-4-1-12(2-5-14)18-8-16(10-27-11-19(25)26)23-24(18)9-13-3-6-15(21)7-17(13)22/h1-8H,9-11H2,(H,25,26)
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US Patent


Assay Description
NCI-H358 lung adenocarcinoma cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345281
PNG
(2-[[1-[(2-Chlorophenyl)methyl]-5-(3- isobutoxyphe...)
Show SMILES CC(C)COc1cccc(c1)-c1cc(COC(C)(C)C(O)=O)nn1Cc1ccccc1Cl
Show InChI InChI=1S/C25H29ClN2O4/c1-17(2)15-31-21-10-7-9-18(12-21)23-13-20(16-32-25(3,4)24(29)30)27-28(23)14-19-8-5-6-11-22(19)26/h5-13,17H,14-16H2,1-4H3,(H,29,30)
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US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345260
PNG
(2-[[5-(4-Chlorophenyl)-1-[(2,4- dichlorophenyl)me...)
Show SMILES OC(=O)COCc1cc(-c2ccc(Cl)cc2)n(Cc2ccc(Cl)cc2Cl)n1
Show InChI InChI=1S/C19H15Cl3N2O3/c20-14-4-1-12(2-5-14)18-8-16(10-27-11-19(25)26)23-24(18)9-13-3-6-15(21)7-17(13)22/h1-8H,9-11H2,(H,25,26)
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US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345334
PNG
(US10202350, Example 81)
Show SMILES COc1cccc(c1)-c1cc(COC(C)(C)C(=O)NS(C)(=O)=O)nn1Cc1ccccc1Cl
Show InChI InChI=1S/C23H26ClN3O5S/c1-23(2,22(28)26-33(4,29)30)32-15-18-13-21(16-9-7-10-19(12-16)31-3)27(25-18)14-17-8-5-6-11-20(17)24/h5-13H,14-15H2,1-4H3,(H,26,28)
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Vettore, LLC

US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345263
PNG
(2-[[5-(2-Chlorophenyl)-1-[(2- chlorophenyl)methyl...)
Show SMILES CC(C)(OCc1cc(-c2ccccc2Cl)n(Cc2ccccc2Cl)n1)C(O)=O
Show InChI InChI=1S/C21H20Cl2N2O3/c1-21(2,20(26)27)28-13-15-11-19(16-8-4-6-10-18(16)23)25(24-15)12-14-7-3-5-9-17(14)22/h3-11H,12-13H2,1-2H3,(H,26,27)
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US Patent


Assay Description
MCT4 may be stably expressed in MDA-MB-453 breast cancer cells that do not express native MCT1 or MCT4. MCT4 activity may be assessed by monitoring t...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345255
PNG
(US10202350, Example 1)
Show SMILES CC(C)(OCc1cc(-c2ccccc2)n(Cc2cccc(Cl)c2)n1)C(O)=O
Show InChI InChI=1S/C21H21ClN2O3/c1-21(2,20(25)26)27-14-18-12-19(16-8-4-3-5-9-16)24(23-18)13-15-7-6-10-17(22)11-15/h3-12H,13-14H2,1-2H3,(H,25,26)
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Vettore, LLC

US Patent


Assay Description
MCT4 may be stably expressed in MDA-MB-453 breast cancer cells that do not express native MCT1 or MCT4. MCT4 activity may be assessed by monitoring t...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345331
PNG
(US10202350, Example 77)
Show SMILES CC(C)(OCc1cc(Cc2ccccc2)n(Cc2ccccc2Cl)n1)C(O)=O
Show InChI InChI=1S/C22H23ClN2O3/c1-22(2,21(26)27)28-15-18-13-19(12-16-8-4-3-5-9-16)25(24-18)14-17-10-6-7-11-20(17)23/h3-11,13H,12,14-15H2,1-2H3,(H,26,27)
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Vettore, LLC

US Patent


Assay Description
MDA-MB-231 breast cancer cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known to ...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345313
PNG
(2-[[1-(4-chlorophenyl)-5-(3-methoxyphenyl)- 1H-py...)
Show SMILES COc1cccc(c1)-c1cc(COC(C)(C)C(O)=O)nn1-c1ccc(Cl)cc1
Show InChI InChI=1S/C21H21ClN2O4/c1-21(2,20(25)26)28-13-16-12-19(14-5-4-6-18(11-14)27-3)24(23-16)17-9-7-15(22)8-10-17/h4-12H,13H2,1-3H3,(H,25,26)
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Vettore, LLC

US Patent


Assay Description
MDA-MB-231 breast cancer cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known to ...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345263
PNG
(2-[[5-(2-Chlorophenyl)-1-[(2- chlorophenyl)methyl...)
Show SMILES CC(C)(OCc1cc(-c2ccccc2Cl)n(Cc2ccccc2Cl)n1)C(O)=O
Show InChI InChI=1S/C21H20Cl2N2O3/c1-21(2,20(26)27)28-13-15-11-19(16-8-4-6-10-18(16)23)25(24-15)12-14-7-3-5-9-17(14)22/h3-11H,12-13H2,1-2H3,(H,26,27)
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Vettore, LLC

US Patent


Assay Description
NCI-H358 lung adenocarcinoma cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345329
PNG
(US10202350, Example 75)
Show SMILES CC(C)(OCc1cc(Nc2ccccc2)n(Cc2ccccc2Cl)n1)C(O)=O
Show InChI InChI=1S/C21H22ClN3O3/c1-21(2,20(26)27)28-14-17-12-19(23-16-9-4-3-5-10-16)25(24-17)13-15-8-6-7-11-18(15)22/h3-12,23H,13-14H2,1-2H3,(H,26,27)
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Vettore, LLC

US Patent


Assay Description
MDA-MB-231 breast cancer cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known to ...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345259
PNG
(2-[[5-(4-Chlorophenyl)-1-[(2,4- dichlorophenyl)me...)
Show SMILES CC(C)(OCc1cc(-c2ccc(Cl)cc2)n(Cc2ccc(Cl)cc2Cl)n1)C(O)=O
Show InChI InChI=1S/C21H19Cl3N2O3/c1-21(2,20(27)28)29-12-17-10-19(13-3-6-15(22)7-4-13)26(25-17)11-14-5-8-16(23)9-18(14)24/h3-10H,11-12H2,1-2H3,(H,27,28)
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Vettore, LLC

US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345330
PNG
(US10202350, Example 76)
Show SMILES CC(C)(OCc1cc(Oc2ccccc2)n(Cc2ccccc2Cl)n1)C(O)=O
Show InChI InChI=1S/C21H21ClN2O4/c1-21(2,20(25)26)27-14-16-12-19(28-17-9-4-3-5-10-17)24(23-16)13-15-8-6-7-11-18(15)22/h3-12H,13-14H2,1-2H3,(H,25,26)
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Vettore, LLC

US Patent


Assay Description
MDA-MB-231 breast cancer cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known to ...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345323
PNG
(US10202350, Example 69)
Show SMILES CC(C)C(=O)Nc1cccc(c1)-c1cc(COC(C)(C)C(O)=O)nn1Cc1ccccc1Cl
Show InChI InChI=1S/C25H28ClN3O4/c1-16(2)23(30)27-19-10-7-9-17(12-19)22-13-20(15-33-25(3,4)24(31)32)28-29(22)14-18-8-5-6-11-21(18)26/h5-13,16H,14-15H2,1-4H3,(H,27,30)(H,31,32)
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Vettore, LLC

US Patent


Assay Description
MDA-MB-231 breast cancer cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known to ...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345264
PNG
(2-[[5-(3-Chlorophenyl)-1-[(2- chlorophenyl)methyl...)
Show SMILES CC(C)(OCc1cc(-c2cccc(Cl)c2)n(Cc2ccccc2Cl)n1)C(O)=O
Show InChI InChI=1S/C21H20Cl2N2O3/c1-21(2,20(26)27)28-13-17-11-19(14-7-5-8-16(22)10-14)25(24-17)12-15-6-3-4-9-18(15)23/h3-11H,12-13H2,1-2H3,(H,26,27)
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Vettore, LLC

US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345296
PNG
(2-[[1-[(2-Chlorophenyl)methyl]-5-[3- (cyclobutylm...)
Show SMILES CC(C)(OCc1cc(-c2cccc(OCC3CCC3)c2)n(Cc2ccccc2Cl)n1)C(O)=O
Show InChI InChI=1S/C26H29ClN2O4/c1-26(2,25(30)31)33-17-21-14-24(29(28-21)15-20-9-3-4-12-23(20)27)19-10-6-11-22(13-19)32-16-18-7-5-8-18/h3-4,6,9-14,18H,5,7-8,15-17H2,1-2H3,(H,30,31)
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Vettore, LLC

US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345301
PNG
(2-([1-[(o-Chlorophenyl)methyl]-5-(1,3- thiazol-4-...)
Show SMILES CC(C)(OCc1cc(-c2cscn2)n(Cc2ccccc2Cl)n1)C(O)=O
Show InChI InChI=1S/C18H18ClN3O3S/c1-18(2,17(23)24)25-9-13-7-16(15-10-26-11-20-15)22(21-13)8-12-5-3-4-6-14(12)19/h3-7,10-11H,8-9H2,1-2H3,(H,23,24)
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Vettore, LLC

US Patent


Assay Description
MDA-MB-231 breast cancer cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known to ...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345271
PNG
(1-[[5-(4-Chlorophenyl)-1-[(2- chlorophenyl)methyl...)
Show SMILES OC(=O)C1(CC1)OCc1cc(-c2ccc(Cl)cc2)n(Cc2ccccc2Cl)n1
Show InChI InChI=1S/C21H18Cl2N2O3/c22-16-7-5-14(6-8-16)19-11-17(13-28-21(9-10-21)20(26)27)24-25(19)12-15-3-1-2-4-18(15)23/h1-8,11H,9-10,12-13H2,(H,26,27)
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Vettore, LLC

US Patent


Assay Description
MCT4 may be stably expressed in MDA-MB-453 breast cancer cells that do not express native MCT1 or MCT4. MCT4 activity may be assessed by monitoring t...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345269
PNG
(2-[[1-[(2-Chlorophenyl)methyl]-5- cyclohexyl-pyra...)
Show SMILES CC(C)(OCc1cc(C2CCCCC2)n(Cc2ccccc2Cl)n1)C(O)=O
Show InChI InChI=1S/C21H27ClN2O3/c1-21(2,20(25)26)27-14-17-12-19(15-8-4-3-5-9-15)24(23-17)13-16-10-6-7-11-18(16)22/h6-7,10-12,15H,3-5,8-9,13-14H2,1-2H3,(H,25,26)
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Vettore, LLC

US Patent


Assay Description
NCI-H358 lung adenocarcinoma cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345256
PNG
(2-[[5-(4-Chlorophenyl)-1-[(4- chlorophenyl)methyl...)
Show SMILES CC(C)(OCc1cc(-c2ccc(Cl)cc2)n(Cc2ccc(Cl)cc2)n1)C(O)=O
Show InChI InChI=1S/C21H20Cl2N2O3/c1-21(2,20(26)27)28-13-18-11-19(15-5-9-17(23)10-6-15)25(24-18)12-14-3-7-16(22)8-4-14/h3-11H,12-13H2,1-2H3,(H,26,27)
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Vettore, LLC

US Patent


Assay Description
MCT4 may be stably expressed in MDA-MB-453 breast cancer cells that do not express native MCT1 or MCT4. MCT4 activity may be assessed by monitoring t...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345274
PNG
(2-[[5-(4-Chlorophenyl)-1-[(2- chlorophenyl)methyl...)
Show SMILES CC(C)(OCc1cc(-c2ccc(Cl)cc2)n(Cc2ccccc2Cl)n1)C(N)=O
Show InChI InChI=1S/C21H21Cl2N3O2/c1-21(2,20(24)27)28-13-17-11-19(14-7-9-16(22)10-8-14)26(25-17)12-15-5-3-4-6-18(15)23/h3-11H,12-13H2,1-2H3,(H2,24,27)
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Vettore, LLC

US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345261
PNG
(2-[[1-Benzyl-5-(4-Chlorophenyl)pyrazol- 3-yl]meth...)
Show SMILES CC(C)(OCc1cc(-c2ccc(Cl)cc2)n(Cc2ccccc2)n1)C(O)=O
Show InChI InChI=1S/C21H21ClN2O3/c1-21(2,20(25)26)27-14-18-12-19(16-8-10-17(22)11-9-16)24(23-18)13-15-6-4-3-5-7-15/h3-12H,13-14H2,1-2H3,(H,25,26)
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Vettore, LLC

US Patent


Assay Description
NCI-H358 lung adenocarcinoma cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345335
PNG
(Methyl 2-[[1-[(2-chlorophenyl)methyl]-5-(3-methoxy...)
Show SMILES COC(=O)C(C)(C)OCc1cc(-c2cccc(OC)c2)n(Cc2ccccc2Cl)n1
Show InChI InChI=1S/C23H25ClN2O4/c1-23(2,22(27)29-4)30-15-18-13-21(16-9-7-10-19(12-16)28-3)26(25-18)14-17-8-5-6-11-20(17)24/h5-13H,14-15H2,1-4H3
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Vettore, LLC

US Patent


Assay Description
MDA-MB-231 breast cancer cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known to ...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345294
PNG
(2-[[1-[(2-Chlorophenyl)methyl]-5-[3- (morpholinom...)
Show SMILES CC(C)(OCc1cc(-c2cccc(CN3CCOCC3)c2)n(Cc2ccccc2Cl)n1)C(O)=O
Show InChI InChI=1S/C26H30ClN3O4/c1-26(2,25(31)32)34-18-22-15-24(30(28-22)17-21-7-3-4-9-23(21)27)20-8-5-6-19(14-20)16-29-10-12-33-13-11-29/h3-9,14-15H,10-13,16-18H2,1-2H3,(H,31,32)
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Vettore, LLC

US Patent


Assay Description
MDA-MB-231 breast cancer cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known to ...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345270
PNG
(2-[[1-[(2-Chlorophenyl)methyl]-5- cyclopentyl-pyr...)
Show SMILES CC(C)(OCc1cc(C2CCCC2)n(Cc2ccccc2Cl)n1)C(O)=O
Show InChI InChI=1S/C20H25ClN2O3/c1-20(2,19(24)25)26-13-16-11-18(14-7-3-4-8-14)23(22-16)12-15-9-5-6-10-17(15)21/h5-6,9-11,14H,3-4,7-8,12-13H2,1-2H3,(H,24,25)
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Vettore, LLC

US Patent


Assay Description
NCI-H358 lung adenocarcinoma cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345261
PNG
(2-[[1-Benzyl-5-(4-Chlorophenyl)pyrazol- 3-yl]meth...)
Show SMILES CC(C)(OCc1cc(-c2ccc(Cl)cc2)n(Cc2ccccc2)n1)C(O)=O
Show InChI InChI=1S/C21H21ClN2O3/c1-21(2,20(25)26)27-14-18-12-19(16-8-10-17(22)11-9-16)24(23-18)13-15-6-4-3-5-7-15/h3-12H,13-14H2,1-2H3,(H,25,26)
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Vettore, LLC

US Patent


Assay Description
MCT4 may be stably expressed in MDA-MB-453 breast cancer cells that do not express native MCT1 or MCT4. MCT4 activity may be assessed by monitoring t...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345271
PNG
(1-[[5-(4-Chlorophenyl)-1-[(2- chlorophenyl)methyl...)
Show SMILES OC(=O)C1(CC1)OCc1cc(-c2ccc(Cl)cc2)n(Cc2ccccc2Cl)n1
Show InChI InChI=1S/C21H18Cl2N2O3/c22-16-7-5-14(6-8-16)19-11-17(13-28-21(9-10-21)20(26)27)24-25(19)12-15-3-1-2-4-18(15)23/h1-8,11H,9-10,12-13H2,(H,26,27)
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Vettore, LLC

US Patent


Assay Description
NCI-H358 lung adenocarcinoma cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345269
PNG
(2-[[1-[(2-Chlorophenyl)methyl]-5- cyclohexyl-pyra...)
Show SMILES CC(C)(OCc1cc(C2CCCCC2)n(Cc2ccccc2Cl)n1)C(O)=O
Show InChI InChI=1S/C21H27ClN2O3/c1-21(2,20(25)26)27-14-17-12-19(15-8-4-3-5-9-15)24(23-17)13-16-10-6-7-11-18(16)22/h6-7,10-12,15H,3-5,8-9,13-14H2,1-2H3,(H,25,26)
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US Patent


Assay Description
MCT4 may be stably expressed in MDA-MB-453 breast cancer cells that do not express native MCT1 or MCT4. MCT4 activity may be assessed by monitoring t...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345270
PNG
(2-[[1-[(2-Chlorophenyl)methyl]-5- cyclopentyl-pyr...)
Show SMILES CC(C)(OCc1cc(C2CCCC2)n(Cc2ccccc2Cl)n1)C(O)=O
Show InChI InChI=1S/C20H25ClN2O3/c1-20(2,19(24)25)26-13-16-11-18(14-7-3-4-8-14)23(22-16)12-15-9-5-6-10-17(15)21/h5-6,9-11,14H,3-4,7-8,12-13H2,1-2H3,(H,24,25)
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Vettore, LLC

US Patent


Assay Description
MCT4 may be stably expressed in MDA-MB-453 breast cancer cells that do not express native MCT1 or MCT4. MCT4 activity may be assessed by monitoring t...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345305
PNG
(US10202350, Example 51)
Show SMILES CC(C)c1cccc(c1)-c1cc(COC(C)(C)C(O)=O)nn1Cc1ccccc1Cl
Show InChI InChI=1S/C24H27ClN2O3/c1-16(2)17-9-7-10-18(12-17)22-13-20(15-30-24(3,4)23(28)29)26-27(22)14-19-8-5-6-11-21(19)25/h5-13,16H,14-15H2,1-4H3,(H,28,29)
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Vettore, LLC

US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345310
PNG
(2-[[5-(3-methoxyphenyl)-1-(pyridin-2-yl)- 1H-pyra...)
Show SMILES COc1cccc(c1)-c1cc(COC(C)(C)C(O)=O)nn1-c1ccccn1
Show InChI InChI=1S/C20H21N3O4/c1-20(2,19(24)25)27-13-15-12-17(14-7-6-8-16(11-14)26-3)23(22-15)18-9-4-5-10-21-18/h4-12H,13H2,1-3H3,(H,24,25)
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Vettore, LLC

US Patent


Assay Description
MDA-MB-231 breast cancer cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known to ...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345331
PNG
(US10202350, Example 77)
Show SMILES CC(C)(OCc1cc(Cc2ccccc2)n(Cc2ccccc2Cl)n1)C(O)=O
Show InChI InChI=1S/C22H23ClN2O3/c1-22(2,21(26)27)28-15-18-13-19(12-16-8-4-3-5-9-16)25(24-18)14-17-10-6-7-11-20(17)23/h3-11,13H,12,14-15H2,1-2H3,(H,26,27)
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Vettore, LLC

US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345293
PNG
(2-[[1-[(2-Chlorophenyl)methyl]-5-[3- (cyclopropox...)
Show SMILES CC(C)(OCc1cc(-c2cccc(OC3CC3)c2)n(Cc2ccccc2Cl)n1)C(O)=O
Show InChI InChI=1S/C24H25ClN2O4/c1-24(2,23(28)29)30-15-18-13-22(16-7-5-8-20(12-16)31-19-10-11-19)27(26-18)14-17-6-3-4-9-21(17)25/h3-9,12-13,19H,10-11,14-15H2,1-2H3,(H,28,29)
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Vettore, LLC

US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345327
PNG
(2-([1-[(2-chlorophenyl)methyl]-5-[3-[(2-methylprop...)
Show SMILES CC(C)CNc1cccc(c1)-c1cc(COC(C)(C)C(O)=O)nn1Cc1ccccc1Cl
Show InChI InChI=1S/C25H30ClN3O3/c1-17(2)14-27-20-10-7-9-18(12-20)23-13-21(16-32-25(3,4)24(30)31)28-29(23)15-19-8-5-6-11-22(19)26/h5-13,17,27H,14-16H2,1-4H3,(H,30,31)
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Vettore, LLC

US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345315
PNG
(2-([1-[(2-methoxyphenyl)methyl]-5-[3-(2- methylpr...)
Show SMILES COc1ccccc1Cn1nc(COC(C)(C)C(O)=O)cc1-c1cccc(OCC(C)C)c1
Show InChI InChI=1S/C26H32N2O5/c1-18(2)16-32-22-11-8-10-19(13-22)23-14-21(17-33-26(3,4)25(29)30)27-28(23)15-20-9-6-7-12-24(20)31-5/h6-14,18H,15-17H2,1-5H3,(H,29,30)
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Vettore, LLC

US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345288
PNG
(2-[[1-[(2-Chlorophenyl)methyl]-5-[3- (trifluorome...)
Show SMILES CC(C)(OCc1cc(-c2cccc(OC(F)(F)F)c2)n(Cc2ccccc2Cl)n1)C(O)=O
Show InChI InChI=1S/C22H20ClF3N2O4/c1-21(2,20(29)30)31-13-16-11-19(14-7-5-8-17(10-14)32-22(24,25)26)28(27-16)12-15-6-3-4-9-18(15)23/h3-11H,12-13H2,1-2H3,(H,29,30)
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Vettore, LLC

US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345299
PNG
(2-[[1-[(2-Chlorophenyl)methyl]-5-[3- (tetrahydrop...)
Show SMILES CC(C)(OCc1cc(-c2cccc(OCC3CCOCC3)c2)n(Cc2ccccc2Cl)n1)C(O)=O
Show InChI InChI=1S/C27H31ClN2O5/c1-27(2,26(31)32)35-18-22-15-25(30(29-22)16-21-6-3-4-9-24(21)28)20-7-5-8-23(14-20)34-17-19-10-12-33-13-11-19/h3-9,14-15,19H,10-13,16-18H2,1-2H3,(H,31,32)
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Vettore, LLC

US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345319
PNG
(US10202350, Example 65)
Show SMILES COc1csc(c1)-c1cc(COC(C)(C)C(O)=O)nn1Cc1ccccc1Cl
Show InChI InChI=1S/C20H21ClN2O4S/c1-20(2,19(24)25)27-11-14-8-17(18-9-15(26-3)12-28-18)23(22-14)10-13-6-4-5-7-16(13)21/h4-9,12H,10-11H2,1-3H3,(H,24,25)
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Vettore, LLC

US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345276
PNG
(2-[[5-(4-Chlorophenyl)-1-(2- pyridylmethyl)pyrazo...)
Show SMILES CC(C)(OCc1cc(-c2ccc(Cl)cc2)n(Cc2ccccn2)n1)C(O)=O
Show InChI InChI=1S/C20H20ClN3O3/c1-20(2,19(25)26)27-13-17-11-18(14-6-8-15(21)9-7-14)24(23-17)12-16-5-3-4-10-22-16/h3-11H,12-13H2,1-2H3,(H,25,26)
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Vettore, LLC

US Patent


Assay Description
MCT4 may be stably expressed in MDA-MB-453 breast cancer cells that do not express native MCT1 or MCT4. MCT4 activity may be assessed by monitoring t...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345282
PNG
(2-[[1-[(2-Chlorophenyl)methyl]-5-(3- ethoxyphenyl...)
Show SMILES CCOc1cccc(c1)-c1cc(COC(C)(C)C(O)=O)nn1Cc1ccccc1Cl
Show InChI InChI=1S/C23H25ClN2O4/c1-4-29-19-10-7-9-16(12-19)21-13-18(15-30-23(2,3)22(27)28)25-26(21)14-17-8-5-6-11-20(17)24/h5-13H,4,14-15H2,1-3H3,(H,27,28)
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Vettore, LLC

US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345332
PNG
(2-[[1-[(2-Chlorophenyl)methyl]-5-(3-hydroxyphenyl)...)
Show SMILES CC(C)(OCc1cc(-c2cccc(O)c2)n(Cc2ccccc2Cl)n1)C(O)=O
Show InChI InChI=1S/C21H21ClN2O4/c1-21(2,20(26)27)28-13-16-11-19(14-7-5-8-17(25)10-14)24(23-16)12-15-6-3-4-9-18(15)22/h3-11,25H,12-13H2,1-2H3,(H,26,27)
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Vettore, LLC

US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345335
PNG
(Methyl 2-[[1-[(2-chlorophenyl)methyl]-5-(3-methoxy...)
Show SMILES COC(=O)C(C)(C)OCc1cc(-c2cccc(OC)c2)n(Cc2ccccc2Cl)n1
Show InChI InChI=1S/C23H25ClN2O4/c1-23(2,22(27)29-4)30-15-18-13-21(16-9-7-10-19(12-16)28-3)26(25-18)14-17-8-5-6-11-20(17)24/h5-13H,14-15H2,1-4H3
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Vettore, LLC

US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345283
PNG
(2-[[1-[(2-Bromophenyl)methyl]-5-(3- isopropoxyphe...)
Show SMILES CC(C)Oc1cccc(c1)-c1cc(COC(C)(C)C(O)=O)nn1Cc1ccccc1Br
Show InChI InChI=1S/C24H27BrN2O4/c1-16(2)31-20-10-7-9-17(12-20)22-13-19(15-30-24(3,4)23(28)29)26-27(22)14-18-8-5-6-11-21(18)25/h5-13,16H,14-15H2,1-4H3,(H,28,29)
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Vettore, LLC

US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345317
PNG
(2-([1-[(4-methoxyphenyl)methyl]-5-[3-(2- methylpr...)
Show SMILES COc1ccc(Cn2nc(COC(C)(C)C(O)=O)cc2-c2cccc(OCC(C)C)c2)cc1
Show InChI InChI=1S/C26H32N2O5/c1-18(2)16-32-23-8-6-7-20(13-23)24-14-21(17-33-26(3,4)25(29)30)27-28(24)15-19-9-11-22(31-5)12-10-19/h6-14,18H,15-17H2,1-5H3,(H,29,30)
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Vettore, LLC

US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345274
PNG
(2-[[5-(4-Chlorophenyl)-1-[(2- chlorophenyl)methyl...)
Show SMILES CC(C)(OCc1cc(-c2ccc(Cl)cc2)n(Cc2ccccc2Cl)n1)C(N)=O
Show InChI InChI=1S/C21H21Cl2N3O2/c1-21(2,20(24)27)28-13-17-11-19(14-7-9-16(22)10-8-14)26(25-17)12-15-5-3-4-6-18(15)23/h3-11H,12-13H2,1-2H3,(H2,24,27)
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Vettore, LLC

US Patent


Assay Description
MCT4 may be stably expressed in MDA-MB-453 breast cancer cells that do not express native MCT1 or MCT4. MCT4 activity may be assessed by monitoring t...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345321
PNG
(2-([1-(o-Chlorophenyl)methyl]-5-(m-methoxyphenyl)-...)
Show SMILES CCC(CC)(OCc1cc(-c2cccc(OC)c2)n(Cc2ccccc2Cl)n1)C(O)=O
Show InChI InChI=1S/C24H27ClN2O4/c1-4-24(5-2,23(28)29)31-16-19-14-22(17-10-8-11-20(13-17)30-3)27(26-19)15-18-9-6-7-12-21(18)25/h6-14H,4-5,15-16H2,1-3H3,(H,28,29)
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US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345267
PNG
(2-[[1-[(2-Chlorophenyl)methyl]-5-[3- (trifluorome...)
Show SMILES CC(C)(OCc1cc(-c2cccc(c2)C(F)(F)F)n(Cc2ccccc2Cl)n1)C(O)=O
Show InChI InChI=1S/C22H20ClF3N2O3/c1-21(2,20(29)30)31-13-17-11-19(14-7-5-8-16(10-14)22(24,25)26)28(27-17)12-15-6-3-4-9-18(15)23/h3-11H,12-13H2,1-2H3,(H,29,30)
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US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345274
PNG
(2-[[5-(4-Chlorophenyl)-1-[(2- chlorophenyl)methyl...)
Show SMILES CC(C)(OCc1cc(-c2ccc(Cl)cc2)n(Cc2ccccc2Cl)n1)C(N)=O
Show InChI InChI=1S/C21H21Cl2N3O2/c1-21(2,20(24)27)28-13-17-11-19(14-7-9-16(22)10-8-14)26(25-17)12-15-5-3-4-6-18(15)23/h3-11H,12-13H2,1-2H3,(H2,24,27)
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Vettore, LLC

US Patent


Assay Description
NCI-H358 lung adenocarcinoma cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345257
PNG
(2-[[5-(4-Chlorophenyl)-1-[(2- chlorophenyl)methyl...)
Show SMILES CC(C)(OCc1cc(-c2ccc(Cl)cc2)n(Cc2ccccc2Cl)n1)C(O)=O
Show InChI InChI=1S/C21H20Cl2N2O3/c1-21(2,20(26)27)28-13-17-11-19(14-7-9-16(22)10-8-14)25(24-17)12-15-5-3-4-6-18(15)23/h3-11H,12-13H2,1-2H3,(H,26,27)
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US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345322
PNG
(2-([1-[(2-Chlorophenyl)methyl]-5-(3-methoxyphenyl)...)
Show SMILES CCC(C)(OCc1cc(-c2cccc(OC)c2)n(Cc2ccccc2Cl)n1)C(O)=O
Show InChI InChI=1S/C23H25ClN2O4/c1-4-23(2,22(27)28)30-15-18-13-21(16-9-7-10-19(12-16)29-3)26(25-18)14-17-8-5-6-11-20(17)24/h5-13H,4,14-15H2,1-3H3,(H,27,28)
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US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345284
PNG
(2-[[1-[(2-Bromophenyl)methyl]-5-(3- methoxyphenyl...)
Show SMILES COc1cccc(c1)-c1cc(COC(C)(C)C(O)=O)nn1Cc1ccccc1Br
Show InChI InChI=1S/C22H23BrN2O4/c1-22(2,21(26)27)29-14-17-12-20(15-8-6-9-18(11-15)28-3)25(24-17)13-16-7-4-5-10-19(16)23/h4-12H,13-14H2,1-3H3,(H,26,27)
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Vettore, LLC

US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345308
PNG
(2-({1-[(o-Chlorophenyl)methyl]-5-(m- methoxypheny...)
Show SMILES COc1cccc(c1)-c1c(C)c(COC(C)(C)C(O)=O)nn1Cc1ccccc1Cl
Show InChI InChI=1S/C23H25ClN2O4/c1-15-20(14-30-23(2,3)22(27)28)25-26(13-17-8-5-6-11-19(17)24)21(15)16-9-7-10-18(12-16)29-4/h5-12H,13-14H2,1-4H3,(H,27,28)
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US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345280
PNG
(2-[[1-[(2-Fluorophenyl)methyl]-5-(3- isobutoxyphe...)
Show SMILES CC(C)COc1cccc(c1)-c1cc(COC(C)(C)C(O)=O)nn1Cc1ccccc1F
Show InChI InChI=1S/C25H29FN2O4/c1-17(2)15-31-21-10-7-9-18(12-21)23-13-20(16-32-25(3,4)24(29)30)27-28(23)14-19-8-5-6-11-22(19)26/h5-13,17H,14-16H2,1-4H3,(H,29,30)
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Vettore, LLC

US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345316
PNG
(2-([1-[(3-methoxyphenyl)methyl]-5-[3-(2- methylpr...)
Show SMILES COc1cccc(Cn2nc(COC(C)(C)C(O)=O)cc2-c2cccc(OCC(C)C)c2)c1
Show InChI InChI=1S/C26H32N2O5/c1-18(2)16-32-23-11-7-9-20(13-23)24-14-21(17-33-26(3,4)25(29)30)27-28(24)15-19-8-6-10-22(12-19)31-5/h6-14,18H,15-17H2,1-5H3,(H,29,30)
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Vettore, LLC

US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345265
PNG
(2-[[1-[(2-Chlorophenyl)methyl]-5-(m- tolyl)pyrazo...)
Show SMILES Cc1cccc(c1)-c1cc(COC(C)(C)C(O)=O)nn1Cc1ccccc1Cl
Show InChI InChI=1S/C22H23ClN2O3/c1-15-7-6-9-16(11-15)20-12-18(14-28-22(2,3)21(26)27)24-25(20)13-17-8-4-5-10-19(17)23/h4-12H,13-14H2,1-3H3,(H,26,27)
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Vettore, LLC

US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345256
PNG
(2-[[5-(4-Chlorophenyl)-1-[(4- chlorophenyl)methyl...)
Show SMILES CC(C)(OCc1cc(-c2ccc(Cl)cc2)n(Cc2ccc(Cl)cc2)n1)C(O)=O
Show InChI InChI=1S/C21H20Cl2N2O3/c1-21(2,20(26)27)28-13-18-11-19(15-5-9-17(23)10-6-15)25(24-18)12-14-3-7-16(22)8-4-14/h3-11H,12-13H2,1-2H3,(H,26,27)
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Vettore, LLC

US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345297
PNG
(2-[[1-[(2-Chlorophenyl)methyl]-5-[3- (2,2,2-trifl...)
Show SMILES CC(C)(OCc1cc(-c2cccc(OCC(F)(F)F)c2)n(Cc2ccccc2Cl)n1)C(O)=O
Show InChI InChI=1S/C23H22ClF3N2O4/c1-22(2,21(30)31)33-13-17-11-20(29(28-17)12-16-6-3-4-9-19(16)24)15-7-5-8-18(10-15)32-14-23(25,26)27/h3-11H,12-14H2,1-2H3,(H,30,31)
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Vettore, LLC

US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345258
PNG
(2-[[1-[(2-Chlorophenyl)methyl]-5-(4- fluorophenyl...)
Show SMILES CC(C)(OCc1cc(-c2ccc(F)cc2)n(Cc2ccccc2Cl)n1)C(O)=O
Show InChI InChI=1S/C21H20ClFN2O3/c1-21(2,20(26)27)28-13-17-11-19(14-7-9-16(23)10-8-14)25(24-17)12-15-5-3-4-6-18(15)22/h3-11H,12-13H2,1-2H3,(H,26,27)
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Vettore, LLC

US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345269
PNG
(2-[[1-[(2-Chlorophenyl)methyl]-5- cyclohexyl-pyra...)
Show SMILES CC(C)(OCc1cc(C2CCCCC2)n(Cc2ccccc2Cl)n1)C(O)=O
Show InChI InChI=1S/C21H27ClN2O3/c1-21(2,20(25)26)27-14-17-12-19(15-8-4-3-5-9-15)24(23-17)13-16-10-6-7-11-18(16)22/h6-7,10-12,15H,3-5,8-9,13-14H2,1-2H3,(H,25,26)
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Vettore, LLC

US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345304
PNG
(2-([1-[(o-Chlorophenyl)methyl]-5-[m- (dimethylami...)
Show SMILES CN(C)c1cccc(c1)-c1cc(COC(C)(C)C(O)=O)nn1Cc1ccccc1Cl
Show InChI InChI=1S/C23H26ClN3O3/c1-23(2,22(28)29)30-15-18-13-21(16-9-7-10-19(12-16)26(3)4)27(25-18)14-17-8-5-6-11-20(17)24/h5-13H,14-15H2,1-4H3,(H,28,29)
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Vettore, LLC

US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345325
PNG
(US10202350, Example 71)
Show SMILES CC(C)(OCc1cc(-c2cccc(NS(C)(=O)=O)c2)n(Cc2ccccc2Cl)n1)C(O)=O
Show InChI InChI=1S/C22H24ClN3O5S/c1-22(2,21(27)28)31-14-18-12-20(15-8-6-9-17(11-15)25-32(3,29)30)26(24-18)13-16-7-4-5-10-19(16)23/h4-12,25H,13-14H2,1-3H3,(H,27,28)
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Vettore, LLC

US Patent


Assay Description
MDA-MB-231 breast cancer cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known to ...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345275
PNG
(2-[[5-(4-chlorophenyl)-1-(4- pyridylmethyl)pyrazo...)
Show SMILES CC(C)(OCc1cc(-c2ccc(Cl)cc2)n(Cc2ccncc2)n1)C(O)=O
Show InChI InChI=1S/C20H20ClN3O3/c1-20(2,19(25)26)27-13-17-11-18(15-3-5-16(21)6-4-15)24(23-17)12-14-7-9-22-10-8-14/h3-11H,12-13H2,1-2H3,(H,25,26)
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Vettore, LLC

US Patent


Assay Description
MCT4 may be stably expressed in MDA-MB-453 breast cancer cells that do not express native MCT1 or MCT4. MCT4 activity may be assessed by monitoring t...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345330
PNG
(US10202350, Example 76)
Show SMILES CC(C)(OCc1cc(Oc2ccccc2)n(Cc2ccccc2Cl)n1)C(O)=O
Show InChI InChI=1S/C21H21ClN2O4/c1-21(2,20(25)26)27-14-16-12-19(28-17-9-4-3-5-10-17)24(23-16)13-15-8-6-7-11-18(15)22/h3-12H,13-14H2,1-2H3,(H,25,26)
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Vettore, LLC

US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345263
PNG
(2-[[5-(2-Chlorophenyl)-1-[(2- chlorophenyl)methyl...)
Show SMILES CC(C)(OCc1cc(-c2ccccc2Cl)n(Cc2ccccc2Cl)n1)C(O)=O
Show InChI InChI=1S/C21H20Cl2N2O3/c1-21(2,20(26)27)28-13-15-11-19(16-8-4-6-10-18(16)23)25(24-15)12-14-7-3-5-9-17(14)22/h3-11H,12-13H2,1-2H3,(H,26,27)
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Vettore, LLC

US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345276
PNG
(2-[[5-(4-Chlorophenyl)-1-(2- pyridylmethyl)pyrazo...)
Show SMILES CC(C)(OCc1cc(-c2ccc(Cl)cc2)n(Cc2ccccn2)n1)C(O)=O
Show InChI InChI=1S/C20H20ClN3O3/c1-20(2,19(25)26)27-13-17-11-18(14-6-8-15(21)9-7-14)24(23-17)12-16-5-3-4-10-22-16/h3-11H,12-13H2,1-2H3,(H,25,26)
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Vettore, LLC

US Patent


Assay Description
NCI-H358 lung adenocarcinoma cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345285
PNG
(2-[[1-[(2-Isopropylphenyl)methyl]-5-(3- methoxyph...)
Show SMILES COc1cccc(c1)-c1cc(COC(C)(C)C(O)=O)nn1Cc1ccccc1C(C)C
Show InChI InChI=1S/C25H30N2O4/c1-17(2)22-12-7-6-9-19(22)15-27-23(18-10-8-11-21(13-18)30-5)14-20(26-27)16-31-25(3,4)24(28)29/h6-14,17H,15-16H2,1-5H3,(H,28,29)
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Vettore, LLC

US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345314
PNG
(US10202350, Example 60)
Show SMILES CC(C)COc1cccc(c1)-c1cc(COC(C)(C)C(O)=O)nn1Cc1ccccc1
Show InChI InChI=1S/C25H30N2O4/c1-18(2)16-30-22-12-8-11-20(13-22)23-14-21(17-31-25(3,4)24(28)29)26-27(23)15-19-9-6-5-7-10-19/h5-14,18H,15-17H2,1-4H3,(H,28,29)
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Vettore, LLC

US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345318
PNG
(US10202350, Example 64)
Show SMILES COc1ccc(s1)-c1cc(COC(C)(C)C(O)=O)nn1Cc1ccccc1Cl
Show InChI InChI=1S/C20H21ClN2O4S/c1-20(2,19(24)25)27-12-14-10-16(17-8-9-18(26-3)28-17)23(22-14)11-13-6-4-5-7-15(13)21/h4-10H,11-12H2,1-3H3,(H,24,25)
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Vettore, LLC

US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345272
PNG
(2-[[1-[(2-Chlorophenyl)methyl]-5-thiazol- 2-yl-py...)
Show SMILES CC(C)(OCc1cc(-c2nccs2)n(Cc2ccccc2Cl)n1)C(O)=O
Show InChI InChI=1S/C18H18ClN3O3S/c1-18(2,17(23)24)25-11-13-9-15(16-20-7-8-26-16)22(21-13)10-12-5-3-4-6-14(12)19/h3-9H,10-11H2,1-2H3,(H,23,24)
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Vettore, LLC

US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345320
PNG
(2-([1-[(2-chlorophenyl)methyl]-5-(5-methoxythiophe...)
Show SMILES COc1cc(cs1)-c1cc(COC(C)(C)C(O)=O)nn1Cc1ccccc1Cl
Show InChI InChI=1S/C20H21ClN2O4S/c1-20(2,19(24)25)27-11-15-9-17(14-8-18(26-3)28-12-14)23(22-15)10-13-6-4-5-7-16(13)21/h4-9,12H,10-11H2,1-3H3,(H,24,25)
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Vettore, LLC

US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345326
PNG
(US10202350, Example 72)
Show SMILES CNc1cccc(c1)-c1cc(COC(C)(C)C(O)=O)nn1Cc1ccccc1Cl
Show InChI InChI=1S/C22H24ClN3O3/c1-22(2,21(27)28)29-14-18-12-20(15-8-6-9-17(11-15)24-3)26(25-18)13-16-7-4-5-10-19(16)23/h4-12,24H,13-14H2,1-3H3,(H,27,28)
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Vettore, LLC

US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345262
PNG
(2-[[1-[(2-Chlorophenyl)methyl]-5-phenyl- pyrazol-...)
Show SMILES CC(C)(OCc1cc(-c2ccccc2)n(Cc2ccccc2Cl)n1)C(O)=O
Show InChI InChI=1S/C21H21ClN2O3/c1-21(2,20(25)26)27-14-17-12-19(15-8-4-3-5-9-15)24(23-17)13-16-10-6-7-11-18(16)22/h3-12H,13-14H2,1-2H3,(H,25,26)
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Vettore, LLC

US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345300
PNG
(2-[[1-[(2-Chlorophenyl)methyl]-5-(3- morpholinoph...)
Show SMILES CC(C)(OCc1cc(-c2cccc(c2)N2CCOCC2)n(Cc2ccccc2Cl)n1)C(O)=O
Show InChI InChI=1S/C25H28ClN3O4/c1-25(2,24(30)31)33-17-20-15-23(29(27-20)16-19-6-3-4-9-22(19)26)18-7-5-8-21(14-18)28-10-12-32-13-11-28/h3-9,14-15H,10-13,16-17H2,1-2H3,(H,30,31)
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US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 4


(Homo sapiens (Human))
BDBM345275
PNG
(2-[[5-(4-chlorophenyl)-1-(4- pyridylmethyl)pyrazo...)
Show SMILES CC(C)(OCc1cc(-c2ccc(Cl)cc2)n(Cc2ccncc2)n1)C(O)=O
Show InChI InChI=1S/C20H20ClN3O3/c1-20(2,19(25)26)27-13-17-11-18(15-3-5-16(21)6-4-15)24(23-17)12-14-7-9-22-10-8-14/h3-11H,12-13H2,1-2H3,(H,25,26)
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Vettore, LLC

US Patent


Assay Description
NCI-H358 lung adenocarcinoma cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345255
PNG
(US10202350, Example 1)
Show SMILES CC(C)(OCc1cc(-c2ccccc2)n(Cc2cccc(Cl)c2)n1)C(O)=O
Show InChI InChI=1S/C21H21ClN2O3/c1-21(2,20(25)26)27-14-18-12-19(16-8-4-3-5-9-16)24(23-18)13-15-7-6-10-17(22)11-15/h3-12H,13-14H2,1-2H3,(H,25,26)
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n/an/a 5.00E+4n/an/an/an/an/an/a



Vettore, LLC

US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345290
PNG
(2-[[5-(3-Methoxyphenyl)-1-[(2- methoxyphenyl)meth...)
Show SMILES COc1cccc(c1)-c1cc(COC(C)(C)C(O)=O)nn1Cc1ccccc1OC
Show InChI InChI=1S/C23H26N2O5/c1-23(2,22(26)27)30-15-18-13-20(16-9-7-10-19(12-16)28-3)25(24-18)14-17-8-5-6-11-21(17)29-4/h5-13H,14-15H2,1-4H3,(H,26,27)
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US Patent
n/an/a 5.00E+4n/an/an/an/an/an/a



Vettore, LLC

US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345302
PNG
(2-([1-[(o-Chlorophenyl)methyl]-5-(m- cyanophenyl)...)
Show SMILES CC(C)(OCc1cc(-c2cccc(c2)C#N)n(Cc2ccccc2Cl)n1)C(O)=O
Show InChI InChI=1S/C22H20ClN3O3/c1-22(2,21(27)28)29-14-18-11-20(16-8-5-6-15(10-16)12-24)26(25-18)13-17-7-3-4-9-19(17)23/h3-11H,13-14H2,1-2H3,(H,27,28)
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n/an/a 5.50E+4n/an/an/an/an/an/a



Vettore, LLC

US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345273
PNG
(2-[[5-(4-Chlorophenyl)-1-[(2- fluorophenyl)methyl...)
Show SMILES CC(C)(OCc1cc(-c2ccc(Cl)cc2)n(Cc2ccccc2F)n1)C(O)=O
Show InChI InChI=1S/C21H20ClFN2O3/c1-21(2,20(26)27)28-13-17-11-19(14-7-9-16(22)10-8-14)25(24-17)12-15-5-3-4-6-18(15)23/h3-11H,12-13H2,1-2H3,(H,26,27)
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n/an/a 5.70E+4n/an/an/an/an/an/a



Vettore, LLC

US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345266
PNG
(2-[[1-[(2-Chlorophenyl)methyl]-5-(3- fluorophenyl...)
Show SMILES CC(C)(OCc1cc(-c2cccc(F)c2)n(Cc2ccccc2Cl)n1)C(O)=O
Show InChI InChI=1S/C21H20ClFN2O3/c1-21(2,20(26)27)28-13-17-11-19(14-7-5-8-16(23)10-14)25(24-17)12-15-6-3-4-9-18(15)22/h3-11H,12-13H2,1-2H3,(H,26,27)
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n/an/a 5.80E+4n/an/an/an/an/an/a



Vettore, LLC

US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345289
PNG
(2-[[1-[(2-Chlorophenyl)methyl]-5-(3- isopropoxyph...)
Show SMILES CC(C)Oc1cccc(c1)-c1cc(COC(C)(C)C(O)=O)nn1Cc1ccccc1Cl
Show InChI InChI=1S/C24H27ClN2O4/c1-16(2)31-20-10-7-9-17(12-20)22-13-19(15-30-24(3,4)23(28)29)26-27(22)14-18-8-5-6-11-21(18)25/h5-13,16H,14-15H2,1-4H3,(H,28,29)
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n/an/a 5.90E+4n/an/an/an/an/an/a



Vettore, LLC

US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345292
PNG
(2-[[1-[[2-(Dimethylamino)phenyl]methyl]- 5-(3-met...)
Show SMILES COc1cccc(c1)-c1cc(COC(C)(C)C(O)=O)nn1Cc1ccccc1N(C)C
Show InChI InChI=1S/C24H29N3O4/c1-24(2,23(28)29)31-16-19-14-22(17-10-8-11-20(13-17)30-5)27(25-19)15-18-9-6-7-12-21(18)26(3)4/h6-14H,15-16H2,1-5H3,(H,28,29)
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n/an/a 6.00E+4n/an/an/an/an/an/a



Vettore, LLC

US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345333
PNG
(US10202350, Example 80)
Show SMILES CC(C)(OCc1cc(-c2cccc(OCC3COC3)c2)n(Cc2ccccc2Cl)n1)C(O)=O
Show InChI InChI=1S/C25H27ClN2O5/c1-25(2,24(29)30)33-16-20-11-23(28(27-20)12-19-6-3-4-9-22(19)26)18-7-5-8-21(10-18)32-15-17-13-31-14-17/h3-11,17H,12-16H2,1-2H3,(H,29,30)
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n/an/a 6.10E+4n/an/an/an/an/an/a



Vettore, LLC

US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345325
PNG
(US10202350, Example 71)
Show SMILES CC(C)(OCc1cc(-c2cccc(NS(C)(=O)=O)c2)n(Cc2ccccc2Cl)n1)C(O)=O
Show InChI InChI=1S/C22H24ClN3O5S/c1-22(2,21(27)28)31-14-18-12-20(15-8-6-9-17(11-15)25-32(3,29)30)26(24-18)13-16-7-4-5-10-19(16)23/h4-12,25H,13-14H2,1-3H3,(H,27,28)
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n/an/a 6.40E+4n/an/an/an/an/an/a



Vettore, LLC

US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345261
PNG
(2-[[1-Benzyl-5-(4-Chlorophenyl)pyrazol- 3-yl]meth...)
Show SMILES CC(C)(OCc1cc(-c2ccc(Cl)cc2)n(Cc2ccccc2)n1)C(O)=O
Show InChI InChI=1S/C21H21ClN2O3/c1-21(2,20(25)26)27-14-18-12-19(16-8-10-17(22)11-9-16)24(23-18)13-15-6-4-3-5-7-15/h3-12H,13-14H2,1-2H3,(H,25,26)
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Vettore, LLC

US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345270
PNG
(2-[[1-[(2-Chlorophenyl)methyl]-5- cyclopentyl-pyr...)
Show SMILES CC(C)(OCc1cc(C2CCCC2)n(Cc2ccccc2Cl)n1)C(O)=O
Show InChI InChI=1S/C20H25ClN2O3/c1-20(2,19(24)25)26-13-16-11-18(14-7-3-4-8-14)23(22-16)12-15-9-5-6-10-17(15)21/h5-6,9-11,14H,3-4,7-8,12-13H2,1-2H3,(H,24,25)
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n/an/a 7.30E+4n/an/an/an/an/an/a



Vettore, LLC

US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345279
PNG
(2-[[1-[(2-Chlorophenyl)methyl]-5-(2- thienyl)pyra...)
Show SMILES CC(C)(OCc1cc(-c2cccs2)n(Cc2ccccc2Cl)n1)C(O)=O
Show InChI InChI=1S/C19H19ClN2O3S/c1-19(2,18(23)24)25-12-14-10-16(17-8-5-9-26-17)22(21-14)11-13-6-3-4-7-15(13)20/h3-10H,11-12H2,1-2H3,(H,23,24)
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Vettore, LLC

US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345312
PNG
(2-[[1-(3-chlorophenyl)-5-(3-methoxyphenyl)- 1H-py...)
Show SMILES COc1cccc(c1)-c1cc(COC(C)(C)C(O)=O)nn1-c1cccc(Cl)c1
Show InChI InChI=1S/C21H21ClN2O4/c1-21(2,20(25)26)28-13-16-12-19(14-6-4-9-18(10-14)27-3)24(23-16)17-8-5-7-15(22)11-17/h4-12H,13H2,1-3H3,(H,25,26)
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n/an/a 7.80E+4n/an/an/an/an/an/a



Vettore, LLC

US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345313
PNG
(2-[[1-(4-chlorophenyl)-5-(3-methoxyphenyl)- 1H-py...)
Show SMILES COc1cccc(c1)-c1cc(COC(C)(C)C(O)=O)nn1-c1ccc(Cl)cc1
Show InChI InChI=1S/C21H21ClN2O4/c1-21(2,20(25)26)28-13-16-12-19(14-5-4-6-18(11-14)27-3)24(23-16)17-9-7-15(22)8-10-17/h4-12H,13H2,1-3H3,(H,25,26)
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Vettore, LLC

US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345286
PNG
(2-[[5-(3-Methoxyphenyl)-1-(o- tolylmethyl)pyrazol...)
Show SMILES COc1cccc(c1)-c1cc(COC(C)(C)C(O)=O)nn1Cc1ccccc1C
Show InChI InChI=1S/C23H26N2O4/c1-16-8-5-6-9-18(16)14-25-21(17-10-7-11-20(12-17)28-4)13-19(24-25)15-29-23(2,3)22(26)27/h5-13H,14-15H2,1-4H3,(H,26,27)
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Vettore, LLC

US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345306
PNG
(2-([1-[(2-chlorophenyl)methyl]-5-[3- (methoxymethy...)
Show SMILES COCc1cccc(c1)-c1cc(COC(C)(C)C(O)=O)nn1Cc1ccccc1Cl
Show InChI InChI=1S/C23H25ClN2O4/c1-23(2,22(27)28)30-15-19-12-21(17-9-6-7-16(11-17)14-29-3)26(25-19)13-18-8-4-5-10-20(18)24/h4-12H,13-15H2,1-3H3,(H,27,28)
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n/an/a 8.40E+4n/an/an/an/an/an/a



Vettore, LLC

US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345278
PNG
(2-[[1-[(2-Chlorophenyl)methyl]-5-(3- thienyl)pyra...)
Show SMILES CC(C)(OCc1cc(-c2ccsc2)n(Cc2ccccc2Cl)n1)C(O)=O
Show InChI InChI=1S/C19H19ClN2O3S/c1-19(2,18(23)24)25-11-15-9-17(14-7-8-26-12-14)22(21-15)10-13-5-3-4-6-16(13)20/h3-9,12H,10-11H2,1-2H3,(H,23,24)
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n/an/a 1.00E+5n/an/an/an/an/an/a



Vettore, LLC

US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345307
PNG
(2-[[1-benzyl-5-(3-methoxyphenyl)-1H- pyrazol-3-yl...)
Show SMILES COc1cccc(c1)-c1cc(COC(C)(C)C(O)=O)nn1Cc1ccccc1
Show InChI InChI=1S/C22H24N2O4/c1-22(2,21(25)26)28-15-18-13-20(17-10-7-11-19(12-17)27-3)24(23-18)14-16-8-5-4-6-9-16/h4-13H,14-15H2,1-3H3,(H,25,26)
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n/an/a 1.00E+5n/an/an/an/an/an/a



Vettore, LLC

US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345324
PNG
(US10202350, Example 70)
Show SMILES CC(C)(OCc1cc(-c2cccc(c2)S(C)(=O)=O)n(Cc2ccccc2Cl)n1)C(O)=O
Show InChI InChI=1S/C22H23ClN2O5S/c1-22(2,21(26)27)30-14-17-12-20(15-8-6-9-18(11-15)31(3,28)29)25(24-17)13-16-7-4-5-10-19(16)23/h4-12H,13-14H2,1-3H3,(H,26,27)
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Vettore, LLC

US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345309
PNG
(2-[[5-(3-methoxyphenyl)-1-phenyl-1H- pyrazol-3-yl...)
Show SMILES COc1cccc(c1)-c1cc(COC(C)(C)C(O)=O)nn1-c1ccccc1
Show InChI InChI=1S/C21H22N2O4/c1-21(2,20(24)25)27-14-16-13-19(15-8-7-11-18(12-15)26-3)23(22-16)17-9-5-4-6-10-17/h4-13H,14H2,1-3H3,(H,24,25)
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Vettore, LLC

US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345329
PNG
(US10202350, Example 75)
Show SMILES CC(C)(OCc1cc(Nc2ccccc2)n(Cc2ccccc2Cl)n1)C(O)=O
Show InChI InChI=1S/C21H22ClN3O3/c1-21(2,20(26)27)28-14-17-12-19(23-16-9-4-3-5-10-16)25(24-17)13-15-8-6-7-11-18(15)22/h3-12,23H,13-14H2,1-2H3,(H,26,27)
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Vettore, LLC

US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345301
PNG
(2-([1-[(o-Chlorophenyl)methyl]-5-(1,3- thiazol-4-...)
Show SMILES CC(C)(OCc1cc(-c2cscn2)n(Cc2ccccc2Cl)n1)C(O)=O
Show InChI InChI=1S/C18H18ClN3O3S/c1-18(2,17(23)24)25-9-13-7-16(15-10-26-11-20-15)22(21-13)8-12-5-3-4-6-14(12)19/h3-7,10-11H,8-9H2,1-2H3,(H,23,24)
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n/an/a 1.00E+5n/an/an/an/an/an/a



Vettore, LLC

US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345268
PNG
(2-[[1-[(2-Chlorophenyl)methyl]-5-(3- methoxypheny...)
Show SMILES COc1cccc(c1)-c1cc(COC(C)(C)C(O)=O)nn1Cc1ccccc1Cl
Show InChI InChI=1S/C22H23ClN2O4/c1-22(2,21(26)27)29-14-17-12-20(15-8-6-9-18(11-15)28-3)25(24-17)13-16-7-4-5-10-19(16)23/h4-12H,13-14H2,1-3H3,(H,26,27)
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Vettore, LLC

US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345323
PNG
(US10202350, Example 69)
Show SMILES CC(C)C(=O)Nc1cccc(c1)-c1cc(COC(C)(C)C(O)=O)nn1Cc1ccccc1Cl
Show InChI InChI=1S/C25H28ClN3O4/c1-16(2)23(30)27-19-10-7-9-17(12-19)22-13-20(15-33-25(3,4)24(31)32)28-29(22)14-18-8-5-6-11-21(18)26/h5-13,16H,14-15H2,1-4H3,(H,27,30)(H,31,32)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.00E+5n/an/an/an/an/an/a



Vettore, LLC

US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345294
PNG
(2-[[1-[(2-Chlorophenyl)methyl]-5-[3- (morpholinom...)
Show SMILES CC(C)(OCc1cc(-c2cccc(CN3CCOCC3)c2)n(Cc2ccccc2Cl)n1)C(O)=O
Show InChI InChI=1S/C26H30ClN3O4/c1-26(2,25(31)32)34-18-22-15-24(30(28-22)17-21-7-3-4-9-23(21)27)20-8-5-6-19(14-20)16-29-10-12-33-13-11-29/h3-9,14-15H,10-13,16-18H2,1-2H3,(H,31,32)
PDB

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GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.00E+5n/an/an/an/an/an/a



Vettore, LLC

US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345328
PNG
(US10202350, Example 74)
Show SMILES CC(C)NC(=O)c1cccc(c1)-c1cc(COC(C)(C)C(O)=O)nn1Cc1ccccc1Cl
Show InChI InChI=1S/C25H28ClN3O4/c1-16(2)27-23(30)18-10-7-9-17(12-18)22-13-20(15-33-25(3,4)24(31)32)28-29(22)14-19-8-5-6-11-21(19)26/h5-13,16H,14-15H2,1-4H3,(H,27,30)(H,31,32)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.00E+5n/an/an/an/an/an/a



Vettore, LLC

US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345268
PNG
(2-[[1-[(2-Chlorophenyl)methyl]-5-(3- methoxypheny...)
Show SMILES COc1cccc(c1)-c1cc(COC(C)(C)C(O)=O)nn1Cc1ccccc1Cl
Show InChI InChI=1S/C22H23ClN2O4/c1-22(2,21(26)27)29-14-17-12-20(15-8-6-9-18(11-15)28-3)25(24-17)13-16-7-4-5-10-19(16)23/h4-12H,13-14H2,1-3H3,(H,26,27)
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 1.00E+5n/an/an/an/an/an/a



Vettore, LLC

US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345303
PNG
(2-([1-[(o-Chlorophenyl)methyl]-5-(1,3- thiazol-5-...)
Show SMILES CC(C)(OCc1cc(-c2cncs2)n(Cc2ccccc2Cl)n1)C(O)=O
Show InChI InChI=1S/C18H18ClN3O3S/c1-18(2,17(23)24)25-10-13-7-15(16-8-20-11-26-16)22(21-13)9-12-5-3-4-6-14(12)19/h3-8,11H,9-10H2,1-2H3,(H,23,24)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.30E+5n/an/an/an/an/an/a



Vettore, LLC

US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345310
PNG
(2-[[5-(3-methoxyphenyl)-1-(pyridin-2-yl)- 1H-pyra...)
Show SMILES COc1cccc(c1)-c1cc(COC(C)(C)C(O)=O)nn1-c1ccccn1
Show InChI InChI=1S/C20H21N3O4/c1-20(2,19(24)25)27-13-15-12-17(14-7-6-8-16(11-14)26-3)23(22-15)18-9-4-5-10-21-18/h4-12H,13H2,1-3H3,(H,24,25)
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/a 1.33E+5n/an/an/an/an/an/a



Vettore, LLC

US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345311
PNG
(2-[[1-(2-chlorophenyl)-5-(3-methoxyphenyl)- 1H-py...)
Show SMILES COc1cccc(c1)-c1cc(COC(C)(C)C(O)=O)nn1-c1ccccc1Cl
Show InChI InChI=1S/C21H21ClN2O4/c1-21(2,20(25)26)28-13-15-12-19(14-7-6-8-16(11-14)27-3)24(23-15)18-10-5-4-9-17(18)22/h4-12H,13H2,1-3H3,(H,25,26)
PDB

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GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.33E+5n/an/an/an/an/an/a



Vettore, LLC

US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345276
PNG
(2-[[5-(4-Chlorophenyl)-1-(2- pyridylmethyl)pyrazo...)
Show SMILES CC(C)(OCc1cc(-c2ccc(Cl)cc2)n(Cc2ccccn2)n1)C(O)=O
Show InChI InChI=1S/C20H20ClN3O3/c1-20(2,19(25)26)27-13-17-11-18(14-6-8-15(21)9-7-14)24(23-17)12-16-5-3-4-10-22-16/h3-11H,12-13H2,1-2H3,(H,25,26)
PDB

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GoogleScholar
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UniChem
US Patent
n/an/a 1.50E+5n/an/an/an/an/an/a



Vettore, LLC

US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345275
PNG
(2-[[5-(4-chlorophenyl)-1-(4- pyridylmethyl)pyrazo...)
Show SMILES CC(C)(OCc1cc(-c2ccc(Cl)cc2)n(Cc2ccncc2)n1)C(O)=O
Show InChI InChI=1S/C20H20ClN3O3/c1-20(2,19(25)26)27-13-17-11-18(15-3-5-16(21)6-4-15)24(23-17)12-14-7-9-22-10-8-14/h3-11H,12-13H2,1-2H3,(H,25,26)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3.00E+5n/an/an/an/an/an/a



Vettore, LLC

US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
Malignant T-cell-amplified sequence 1


(Homo sapiens (human))
BDBM345277
PNG
(2-[[5-(4-Chlorophenyl)-1-(3- pyridylmethyl)pyrazo...)
Show SMILES CC(C)(OCc1cc(-c2ccc(Cl)cc2)n(Cc2cccnc2)n1)C(O)=O
Show InChI InChI=1S/C20H20ClN3O3/c1-20(2,19(25)26)27-13-17-10-18(15-5-7-16(21)8-6-15)24(23-17)12-14-4-3-9-22-11-14/h3-11H,12-13H2,1-2H3,(H,25,26)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3.00E+5n/an/an/an/an/an/a



Vettore, LLC

US Patent


Assay Description
MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...


US Patent US10202350 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%