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Patent code US10202354

Compile Data Set for Download or QSAR
Found 120 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345367
PNG
(1-cyclobutyl-4-(1-tetralin-6-ylsulfonyl-4,5-dihydr...)
Show SMILES O=S(=O)(N1CCN=C1N1CCN(CC1)C1CCC1)c1ccc2CCCCc2c1
Show InChI InChI=1S/C21H30N4O2S/c26-28(27,20-9-8-17-4-1-2-5-18(17)16-20)25-11-10-22-21(25)24-14-12-23(13-15-24)19-6-3-7-19/h8-9,16,19H,1-7,10-15H2
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0160n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345355
PNG
(1-cyclobutyl-4-[1-[4-(3-thienyl)phenyl]sulfonyl-4,...)
Show SMILES O=S(=O)(N1CCN=C1N1CCN(CC1)C1CCC1)c1ccc(cc1)-c1ccsc1
Show InChI InChI=1S/C21H26N4O2S2/c26-29(27,20-6-4-17(5-7-20)18-8-15-28-16-18)25-10-9-22-21(25)24-13-11-23(12-14-24)19-2-1-3-19/h4-8,15-16,19H,1-3,9-14H2
PDB

UniProtKB/SwissProt

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UniChem
US Patent
n/an/a 0.0210n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345352
PNG
(4-[4-[[2-(4-cyclobutylpiperazin-1-yl)-4,5-dihydroi...)
Show SMILES Oc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C23H28N4O3S/c28-21-8-4-18(5-9-21)19-6-10-22(11-7-19)31(29,30)27-13-12-24-23(27)26-16-14-25(15-17-26)20-2-1-3-20/h4-11,20,28H,1-3,12-17H2
PDB

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PC sid
UniChem
US Patent
n/an/a 0.0210n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345354
PNG
(1-cyclobutyl-4-[1-[4-(2-thienyl)phenyl]sulfonyl-4,...)
Show SMILES O=S(=O)(N1CCN=C1N1CCN(CC1)C1CCC1)c1ccc(cc1)-c1cccs1
Show InChI InChI=1S/C21H26N4O2S2/c26-29(27,19-8-6-17(7-9-19)20-5-2-16-28-20)25-11-10-22-21(25)24-14-12-23(13-15-24)18-3-1-4-18/h2,5-9,16,18H,1,3-4,10-15H2
PDB

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PC sid
UniChem
US Patent
n/an/a 0.0270n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345410
PNG
(1-cyclobutyl-4-(1-indan-5-ylsulfonyl-4,5-dihydroim...)
Show SMILES O=S(=O)(N1CCN=C1N1CCN(CC1)C1CCC1)c1ccc2CCCc2c1
Show InChI InChI=1S/C20H28N4O2S/c25-27(26,19-8-7-16-3-1-4-17(16)15-19)24-10-9-21-20(24)23-13-11-22(12-14-23)18-5-2-6-18/h7-8,15,18H,1-6,9-14H2
PDB

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PC sid
UniChem
US Patent
n/an/a 0.0310n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345351
PNG
(3-[4-[[2-(4-cyclobutylpiperazin-1-yl)-4,5-dihydroi...)
Show SMILES Oc1cccc(c1)-c1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C23H28N4O3S/c28-21-6-1-3-19(17-21)18-7-9-22(10-8-18)31(29,30)27-12-11-24-23(27)26-15-13-25(14-16-26)20-4-2-5-20/h1,3,6-10,17,20,28H,2,4-5,11-16H2
PDB

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UniChem
US Patent
n/an/a 0.0340n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345393
PNG
(1-cyclobutyl-4-[1-[4-(1,1-dimethylpropyl)phenyl]su...)
Show SMILES CCC(C)(C)c1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C22H34N4O2S/c1-4-22(2,3)18-8-10-20(11-9-18)29(27,28)26-13-12-23-21(26)25-16-14-24(15-17-25)19-6-5-7-19/h8-11,19H,4-7,12-17H2,1-3H3
PDB

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UniChem
US Patent
n/an/a 0.0350n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345350
PNG
(2-[4-[[2-(4-cyclobutylpiperazin-1-yl)-4,5-dihydroi...)
Show SMILES Oc1ccccc1-c1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C23H28N4O3S/c28-22-7-2-1-6-21(22)18-8-10-20(11-9-18)31(29,30)27-13-12-24-23(27)26-16-14-25(15-17-26)19-4-3-5-19/h1-2,6-11,19,28H,3-5,12-17H2
PDB

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PC sid
UniChem
US Patent
n/an/a 0.0370n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345376
PNG
(US10202354, Example 41)
Show SMILES CC(C)c1ccc(cc1)S(=O)(=O)N1C[C@H](N=C1N1CCN(CC1)C1CCC1)C1CC1
Show InChI InChI=1S/C23H34N4O2S/c1-17(2)18-8-10-21(11-9-18)30(28,29)27-16-22(19-6-7-19)24-23(27)26-14-12-25(13-15-26)20-4-3-5-20/h8-11,17,19-20,22H,3-7,12-16H2,1-2H3/t22-/m0/s1
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PC sid
UniChem
US Patent
n/an/a 0.0390n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345408
PNG
(1-cyclobutyl-4-[1-[(6-methoxy-2-naphthyl)sulfonyl]...)
Show SMILES COc1ccc2cc(ccc2c1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C22H28N4O3S/c1-29-20-7-5-18-16-21(8-6-17(18)15-20)30(27,28)26-10-9-23-22(26)25-13-11-24(12-14-25)19-3-2-4-19/h5-8,15-16,19H,2-4,9-14H2,1H3
PDB

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PC sid
UniChem
US Patent
n/an/a 0.0410n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345409
PNG
(1-[1-[(6-chloro-2-naphthyl)sulfonyl]-4,5-dihydroim...)
Show SMILES Clc1ccc2cc(ccc2c1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C21H25ClN4O2S/c22-18-6-4-17-15-20(7-5-16(17)14-18)29(27,28)26-9-8-23-21(26)25-12-10-24(11-13-25)19-2-1-3-19/h4-7,14-15,19H,1-3,8-13H2
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/a 0.0410n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345366
PNG
(1-cyclobutyl-4-(1-((4-isopropylphenyl)sulfonyl)-4,...)
Show SMILES CC(C)c1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C20H30N4O2S/c1-16(2)17-6-8-19(9-7-17)27(25,26)24-11-10-21-20(24)23-14-12-22(13-15-23)18-4-3-5-18/h6-9,16,18H,3-5,10-15H2,1-2H3
PDB

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PC sid
UniChem
US Patent
n/an/a 0.0430n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345360
PNG
(1-cyclobutyl-4-[1-[4-(2-fluorophenyl)phe-nyl]sulfo...)
Show SMILES Fc1ccccc1-c1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C23H27FN4O2S/c24-22-7-2-1-6-21(22)18-8-10-20(11-9-18)31(29,30)28-13-12-25-23(28)27-16-14-26(15-17-27)19-4-3-5-19/h1-2,6-11,19H,3-5,12-17H2
PDB

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PC sid
UniChem
US Patent
n/an/a 0.0460n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345377
PNG
(US10202354, Example 42)
Show SMILES CC(C)c1ccc(cc1)S(=O)(=O)N1C[C@@H](N=C1N1CCN(CC1)C1CCC1)C1CC1
Show InChI InChI=1S/C23H34N4O2S/c1-17(2)18-8-10-21(11-9-18)30(28,29)27-16-22(19-6-7-19)24-23(27)26-14-12-25(13-15-26)20-4-3-5-20/h8-11,17,19-20,22H,3-7,12-16H2,1-2H3/t22-/m1/s1
PDB

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UniChem
US Patent
n/an/a 0.0470n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345349
PNG
(1-cyclobutyl-4-[1-(4-phenylphenyl)sulfonyl-4,5-dih...)
Show SMILES O=S(=O)(N1CCN=C1N1CCN(CC1)C1CCC1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C23H28N4O2S/c28-30(29,22-11-9-20(10-12-22)19-5-2-1-3-6-19)27-14-13-24-23(27)26-17-15-25(16-18-26)21-7-4-8-21/h1-3,5-6,9-12,21H,4,7-8,13-18H2
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/a 0.0480n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345380
PNG
(2-(4-cyclobutylpiperazin-1-yl)-3-(4-isopropylpheny...)
Show SMILES CC(C)c1ccc(cc1)S(=O)(=O)N1CC2(CCCC2)N=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C24H36N4O2S/c1-19(2)20-8-10-22(11-9-20)31(29,30)28-18-24(12-3-4-13-24)25-23(28)27-16-14-26(15-17-27)21-6-5-7-21/h8-11,19,21H,3-7,12-18H2,1-2H3
PDB

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PC sid
UniChem
US Patent
n/an/a 0.0490n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345364
PNG
(1-cyclobutyl-4-[1-[4-(2-methylpyrazol-3-yl)phenyl]...)
Show SMILES Cn1nccc1-c1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C21H28N6O2S/c1-24-20(9-10-23-24)17-5-7-19(8-6-17)30(28,29)27-12-11-22-21(27)26-15-13-25(14-16-26)18-3-2-4-18/h5-10,18H,2-4,11-16H2,1H3
PDB

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PC sid
UniChem
US Patent
n/an/a 0.0490n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345363
PNG
(1-cyclobutyl-4-[1-[4-(1-methylpyrazol-3-yl)phenyl]...)
Show SMILES Cn1ccc(n1)-c1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C21H28N6O2S/c1-24-11-9-20(23-24)17-5-7-19(8-6-17)30(28,29)27-12-10-22-21(27)26-15-13-25(14-16-26)18-3-2-4-18/h5-9,11,18H,2-4,10,12-16H2,1H3
PDB

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PC sid
UniChem
US Patent
n/an/a 0.0490n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345389
PNG
(1-cyclobutyl-4-[1-(3-phenylphenyl)sulfonyl-4,5-dih...)
Show SMILES O=S(=O)(N1CCN=C1N1CCN(CC1)C1CCC1)c1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C23H28N4O2S/c28-30(29,22-11-4-8-20(18-22)19-6-2-1-3-7-19)27-13-12-24-23(27)26-16-14-25(15-17-26)21-9-5-10-21/h1-4,6-8,11,18,21H,5,9-10,12-17H2
PDB

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PC sid
UniChem
US Patent
n/an/a 0.0490n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345400
PNG
(1-cyclobutyl-4-[1-(4-phenoxyphenyl)sulfonyl-4,5-di...)
Show SMILES O=S(=O)(N1CCN=C1N1CCN(CC1)C1CCC1)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C23H28N4O3S/c28-31(29,22-11-9-21(10-12-22)30-20-7-2-1-3-8-20)27-14-13-24-23(27)26-17-15-25(16-18-26)19-5-4-6-19/h1-3,7-12,19H,4-6,13-18H2
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/a 0.0500n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345359
PNG
(1-cyclobutyl-4-[1-[4- | US10202354, Example 24)
Show SMILES COc1ccccc1-c1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C24H30N4O3S/c1-31-23-8-3-2-7-22(23)19-9-11-21(12-10-19)32(29,30)28-14-13-25-24(28)27-17-15-26(16-18-27)20-5-4-6-20/h2-3,7-12,20H,4-6,13-18H2,1H3
PDB

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UniChem
US Patent
n/an/a 0.0500n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345336
PNG
(2-[4-[[2-(4-cyclobutylpiperazin-1-yl)-4,5-dihydroi...)
Show SMILES O=S(=O)(N1CCN=C1N1CCN(CC1)C1CCC1)c1ccc(cc1)-c1ccccc1C#N
Show InChI InChI=1S/C24H27N5O2S/c25-18-20-4-1-2-7-23(20)19-8-10-22(11-9-19)32(30,31)29-13-12-26-24(29)28-16-14-27(15-17-28)21-5-3-6-21/h1-2,4,7-11,21H,3,5-6,12-17H2
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US Patent
n/an/a 0.0530n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345381
PNG
((R)-1-cyclobutyl-4-[1-(4-isopropylphenyl)sulfonyl-...)
Show SMILES CC(C)c1ccc(cc1)S(=O)(=O)N1C[C@@H](C)N=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C21H32N4O2S/c1-16(2)18-7-9-20(10-8-18)28(26,27)25-15-17(3)22-21(25)24-13-11-23(12-14-24)19-5-4-6-19/h7-10,16-17,19H,4-6,11-15H2,1-3H3/t17-/m1/s1
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US Patent
n/an/a 0.0540n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345369
PNG
(1-cyclobutyl-4-[1-(4-cyclopropylphenyl)sulfonyl-4,...)
Show SMILES O=S(=O)(N1CCN=C1N1CCN(CC1)C1CCC1)c1ccc(cc1)C1CC1
Show InChI InChI=1S/C20H28N4O2S/c25-27(26,19-8-6-17(7-9-19)16-4-5-16)24-11-10-21-20(24)23-14-12-22(13-15-23)18-2-1-3-18/h6-9,16,18H,1-5,10-15H2
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US Patent
n/an/a 0.0580n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345365
PNG
(5-[4-[[2-(4-cyclobutylpiperazin-1-yl)-4,5-dihydroi...)
Show SMILES O=S(=O)(N1CCN=C1N1CCN(CC1)C1CCC1)c1ccc(cc1)-c1cncnc1
Show InChI InChI=1S/C21H26N6O2S/c28-30(29,20-6-4-17(5-7-20)18-14-22-16-23-15-18)27-9-8-24-21(27)26-12-10-25(11-13-26)19-2-1-3-19/h4-7,14-16,19H,1-3,8-13H2
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n/an/a 0.0600n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345414
PNG
(5-[[2-(4-cyclobutylpiperazin-1-yl)-4,5-dihydroimid...)
Show SMILES Cn1ccc2cc(ccc12)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C20H27N5O2S/c1-22-9-7-16-15-18(5-6-19(16)22)28(26,27)25-10-8-21-20(25)24-13-11-23(12-14-24)17-3-2-4-17/h5-7,9,15,17H,2-4,8,10-14H2,1H3
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US Patent
n/an/a 0.0620n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345396
PNG
(1-cyclobutyl-4-[1-(2-naphthylsulfonyl)-4,5-dihydro...)
Show SMILES O=S(=O)(N1CCN=C1N1CCN(CC1)C1CCC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C21H26N4O2S/c26-28(27,20-9-8-17-4-1-2-5-18(17)16-20)25-11-10-22-21(25)24-14-12-23(13-15-24)19-6-3-7-19/h1-2,4-5,8-9,16,19H,3,6-7,10-15H2
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n/an/a 0.0620n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345362
PNG
(1-cyclobutyl-4-[1-[4-(4-fluorophenyl)phe-nyl]sulfo...)
Show SMILES Fc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C23H27FN4O2S/c24-20-8-4-18(5-9-20)19-6-10-22(11-7-19)31(29,30)28-13-12-25-23(28)27-16-14-26(15-17-27)21-2-1-3-21/h4-11,21H,1-3,12-17H2
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n/an/a 0.0710n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345344
PNG
(1-cyclobutyl-4-[1-[4-(m-tolyl)phenyl]sulfonyl-4,5-...)
Show SMILES Cc1cccc(c1)-c1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C24H30N4O2S/c1-19-4-2-5-21(18-19)20-8-10-23(11-9-20)31(29,30)28-13-12-25-24(28)27-16-14-26(15-17-27)22-6-3-7-22/h2,4-5,8-11,18,22H,3,6-7,12-17H2,1H3
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n/an/a 0.0740n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345343
PNG
(1-cyclobutyl-4-[1-[4-(o-tolyl)phenyl]sulfonyl-4,5-...)
Show SMILES Cc1ccccc1-c1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C24H30N4O2S/c1-19-5-2-3-8-23(19)20-9-11-22(12-10-20)31(29,30)28-14-13-25-24(28)27-17-15-26(16-18-27)21-6-4-7-21/h2-3,5,8-12,21H,4,6-7,13-18H2,1H3
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n/an/a 0.0770n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345413
PNG
(1-cyclobutyl-4-[1-[(6-methyl-2-naphthyl)sulfonyl]-...)
Show SMILES Cc1ccc2cc(ccc2c1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C22H28N4O2S/c1-17-5-6-19-16-21(8-7-18(19)15-17)29(27,28)26-10-9-23-22(26)25-13-11-24(12-14-25)20-3-2-4-20/h5-8,15-16,20H,2-4,9-14H2,1H3
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n/an/a 0.0770n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345338
PNG
(1-cyclobutyl-4-[1-[4-(4-methoxyphenyl)phe-nyl]sulf...)
Show SMILES COc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C24H30N4O3S/c1-31-22-9-5-19(6-10-22)20-7-11-23(12-8-20)32(29,30)28-14-13-25-24(28)27-17-15-26(16-18-27)21-3-2-4-21/h5-12,21H,2-4,13-18H2,1H3
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n/an/a 0.0800n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345388
PNG
(1-[4-tert-butylphenyl)sulfonyl-4,5-dihydroimidazol...)
Show SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C21H32N4O2S/c1-21(2,3)17-7-9-19(10-8-17)28(26,27)25-12-11-22-20(25)24-15-13-23(14-16-24)18-5-4-6-18/h7-10,18H,4-6,11-16H2,1-3H3
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n/an/a 0.0810n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345356
PNG
(1-[1-[4-(2-chlorophenyl)phe-nyl]sulfonyl-4,5-dihyd...)
Show SMILES Clc1ccccc1-c1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C23H27ClN4O2S/c24-22-7-2-1-6-21(22)18-8-10-20(11-9-18)31(29,30)28-13-12-25-23(28)27-16-14-26(15-17-27)19-4-3-5-19/h1-2,6-11,19H,3-5,12-17H2
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n/an/a 0.0840n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345370
PNG
(1-cyclobutyl-4-[1-(3-cyclopropylphenyl)sulfonyl-4,...)
Show SMILES O=S(=O)(N1CCN=C1N1CCN(CC1)C1CCC1)c1cccc(c1)C1CC1
Show InChI InChI=1S/C20H28N4O2S/c25-27(26,19-6-1-3-17(15-19)16-7-8-16)24-10-9-21-20(24)23-13-11-22(12-14-23)18-4-2-5-18/h1,3,6,15-16,18H,2,4-5,7-14H2
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n/an/a 0.0870n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345391
PNG
(1-cyclobutyl-4-[1-(3,5-dimethylphenyl)sulfonyl-4,5...)
Show SMILES Cc1cc(C)cc(c1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C19H28N4O2S/c1-15-12-16(2)14-18(13-15)26(24,25)23-7-6-20-19(23)22-10-8-21(9-11-22)17-4-3-5-17/h12-14,17H,3-11H2,1-2H3
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n/an/a 0.0880n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345405
PNG
(N-[4-[[2-(4-cyclobutylpiperazin-1-yl)-4,5-dihydroi...)
Show SMILES CC(=O)Nc1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C19H27N5O3S/c1-15(25)21-16-5-7-18(8-6-16)28(26,27)24-10-9-20-19(24)23-13-11-22(12-14-23)17-3-2-4-17/h5-8,17H,2-4,9-14H2,1H3,(H,21,25)
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n/an/a 0.0940n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345353
PNG
(1-cyclobutyl-4-[1-[4-(4-pyridyl)phenyl]sulfonyl-4,...)
Show SMILES O=S(=O)(N1CCN=C1N1CCN(CC1)C1CCC1)c1ccc(cc1)-c1ccncc1
Show InChI InChI=1S/C22H27N5O2S/c28-30(29,21-6-4-18(5-7-21)19-8-10-23-11-9-19)27-13-12-24-22(27)26-16-14-25(15-17-26)20-2-1-3-20/h4-11,20H,1-3,12-17H2
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n/an/a 0.0950n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345340
PNG
(4-[4-[[2-(4-cyclobutylpiperazin-1-yl)-4,5-dihydroi...)
Show SMILES O=S(=O)(N1CCN=C1N1CCN(CC1)C1CCC1)c1ccc(cc1)-c1ccc(cc1)C#N
Show InChI InChI=1S/C24H27N5O2S/c25-18-19-4-6-20(7-5-19)21-8-10-23(11-9-21)32(30,31)29-13-12-26-24(29)28-16-14-27(15-17-28)22-2-1-3-22/h4-11,22H,1-3,12-17H2
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n/an/a 0.0970n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345337
PNG
(1-cyclobutyl-4-[1-[4-(3-methoxyphenyl)phe-nyl]sulf...)
Show SMILES COc1cccc(c1)-c1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C24H30N4O3S/c1-31-22-7-2-4-20(18-22)19-8-10-23(11-9-19)32(29,30)28-13-12-25-24(28)27-16-14-26(15-17-27)21-5-3-6-21/h2,4,7-11,18,21H,3,5-6,12-17H2,1H3
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n/an/a 0.0980n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345341
PNG
(1-cyclobutyl-4-[1-[4-(2-pyridyl)phenyl]sulfonyl-4,...)
Show SMILES O=S(=O)(N1CCN=C1N1CCN(CC1)C1CCC1)c1ccc(cc1)-c1ccccn1
Show InChI InChI=1S/C22H27N5O2S/c28-30(29,20-9-7-18(8-10-20)21-6-1-2-11-23-21)27-13-12-24-22(27)26-16-14-25(15-17-26)19-4-3-5-19/h1-2,6-11,19H,3-5,12-17H2
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n/an/a 0.102n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345339
PNG
(1-cyclobutyl-4-[1-[4-[2-(trifluoromethyl)phe-nyl]p...)
Show SMILES FC(F)(F)c1ccccc1-c1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C24H27F3N4O2S/c25-24(26,27)22-7-2-1-6-21(22)18-8-10-20(11-9-18)34(32,33)31-13-12-28-23(31)30-16-14-29(15-17-30)19-4-3-5-19/h1-2,6-11,19H,3-5,12-17H2
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US Patent
n/an/a 0.102n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345415
PNG
(6-[[2-(4-cyclobutylpiperazin-1-yl)-4,5-dihydroimid...)
Show SMILES Cc1nc2ccc(cc2s1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C19H25N5O2S2/c1-14-21-17-6-5-16(13-18(17)27-14)28(25,26)24-8-7-20-19(24)23-11-9-22(10-12-23)15-3-2-4-15/h5-6,13,15H,2-4,7-12H2,1H3
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US Patent
n/an/a 0.112n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345382
PNG
((S)-1-cyclobutyl-4-[1-(4-isopropylphenyl)sulfonyl-...)
Show SMILES CC(C)c1ccc(cc1)S(=O)(=O)N1C[C@H](C)N=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C21H32N4O2S/c1-16(2)18-7-9-20(10-8-18)28(26,27)25-15-17(3)22-21(25)24-13-11-23(12-14-24)19-5-4-6-19/h7-10,16-17,19H,4-6,11-15H2,1-3H3/t17-/m0/s1
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US Patent
n/an/a 0.114n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345357
PNG
(1-[1-[4-(3-chlorophenyl)phe-nyl]sulfonyl-4,5-dihyd...)
Show SMILES Clc1cccc(c1)-c1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C23H27ClN4O2S/c24-20-4-1-3-19(17-20)18-7-9-22(10-8-18)31(29,30)28-12-11-25-23(28)27-15-13-26(14-16-27)21-5-2-6-21/h1,3-4,7-10,17,21H,2,5-6,11-16H2
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US Patent
n/an/a 0.120n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345416
PNG
(N-[2-chloro-4-[[2-(4-cyclobutylpiperazin-1-yl)-4,5...)
Show SMILES CC(=O)Nc1ccc(cc1Cl)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C19H26ClN5O3S/c1-14(26)22-18-6-5-16(13-17(18)20)29(27,28)25-8-7-21-19(25)24-11-9-23(10-12-24)15-3-2-4-15/h5-6,13,15H,2-4,7-12H2,1H3,(H,22,26)
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n/an/a 0.127n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345371
PNG
(6-[[2-(4-cyclobutylpiperazin-1-yl)-4,5-dihydroimid...)
Show SMILES O=S(=O)(N1CCN=C1N1CCN(CC1)C1CCC1)c1ccc2cc(ccc2c1)C#N
Show InChI InChI=1S/C22H25N5O2S/c23-16-17-4-5-19-15-21(7-6-18(19)14-17)30(28,29)27-9-8-24-22(27)26-12-10-25(11-13-26)20-2-1-3-20/h4-7,14-15,20H,1-3,8-13H2
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US Patent
n/an/a 0.130n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345346
PNG
(1-cyclobutyl-4-[1-[4-[3-(trifluoromethyl)phe-nyl]p...)
Show SMILES FC(F)(F)c1cccc(c1)-c1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C24H27F3N4O2S/c25-24(26,27)20-4-1-3-19(17-20)18-7-9-22(10-8-18)34(32,33)31-12-11-28-23(31)30-15-13-29(14-16-30)21-5-2-6-21/h1,3-4,7-10,17,21H,2,5-6,11-16H2
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US Patent
n/an/a 0.134n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345402
PNG
(1-cyclobutyl-4-[1-(3,4-dichlorophenyl)sulfonyl-4,5...)
Show SMILES Clc1ccc(cc1Cl)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C17H22Cl2N4O2S/c18-15-5-4-14(12-16(15)19)26(24,25)23-7-6-20-17(23)22-10-8-21(9-11-22)13-2-1-3-13/h4-5,12-13H,1-3,6-11H2
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US Patent
n/an/a 0.136n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345398
PNG
(1-[4-[[2-(4-cyclobutylpiperazin-1-yl)-4,5-dihydroi...)
Show SMILES CNC(=O)Nc1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C19H28N6O3S/c1-20-18(26)22-15-5-7-17(8-6-15)29(27,28)25-10-9-21-19(25)24-13-11-23(12-14-24)16-3-2-4-16/h5-8,16H,2-4,9-14H2,1H3,(H2,20,22,26)
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US Patent
n/an/a 0.138n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345361
PNG
(1-cyclobutyl-4-[1-[4-(3-fluorophenyl)phe-nyl]sulfo...)
Show SMILES Fc1cccc(c1)-c1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C23H27FN4O2S/c24-20-4-1-3-19(17-20)18-7-9-22(10-8-18)31(29,30)28-12-11-25-23(28)27-15-13-26(14-16-27)21-5-2-6-21/h1,3-4,7-10,17,21H,2,5-6,11-16H2
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US Patent
n/an/a 0.138n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345392
PNG
(1-cyclobutyl-4-[1-(2,4-dimethylphenyl)sulfonyl-4,5...)
Show SMILES Cc1ccc(c(C)c1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C19H28N4O2S/c1-15-6-7-18(16(2)14-15)26(24,25)23-9-8-20-19(23)22-12-10-21(11-13-22)17-4-3-5-17/h6-7,14,17H,3-5,8-13H2,1-2H3
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US Patent
n/an/a 0.139n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345401
PNG
(4-[[2-(4-cyclobutylpiperazin-1-yl)-4,5-dihydroimid...)
Show SMILES O=S(=O)(N1CCN=C1N1CCN(CC1)C1CCC1)c1cccc2nsnc12
Show InChI InChI=1S/C17H22N6O2S2/c24-27(25,15-6-2-5-14-16(15)20-26-19-14)23-8-7-18-17(23)22-11-9-21(10-12-22)13-3-1-4-13/h2,5-6,13H,1,3-4,7-12H2
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US Patent
n/an/a 0.141n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345345
PNG
(1-cyclobutyl-4-[1-[4-(p-tolyl)phenyl]sulfonyl-4,5-...)
Show SMILES Cc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C24H30N4O2S/c1-19-5-7-20(8-6-19)21-9-11-23(12-10-21)31(29,30)28-14-13-25-24(28)27-17-15-26(16-18-27)22-3-2-4-22/h5-12,22H,2-4,13-18H2,1H3
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n/an/a 0.145n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345348
PNG
(3-[4-[[2-(4-cyclobutylpiperazin-1-y])-4,5-dihydroi...)
Show SMILES O=S(=O)(N1CCN=C1N1CCN(CC1)C1CCC1)c1ccc(cc1)-c1cccc(c1)C#N
Show InChI InChI=1S/C24H27N5O2S/c25-18-19-3-1-4-21(17-19)20-7-9-23(10-8-20)32(30,31)29-12-11-26-24(29)28-15-13-27(14-16-28)22-5-2-6-22/h1,3-4,7-10,17,22H,2,5-6,11-16H2
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n/an/a 0.145n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345394
PNG
(1-cyclobutyl-4-[1-(m-tolylsulfonyl)-4,5-dihydroimi...)
Show SMILES Cc1cccc(c1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C18H26N4O2S/c1-15-4-2-7-17(14-15)25(23,24)22-9-8-19-18(22)21-12-10-20(11-13-21)16-5-3-6-16/h2,4,7,14,16H,3,5-6,8-13H2,1H3
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US Patent
n/an/a 0.146n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345427
PNG
(1-[1-(4-isopropylphenyl)sulfonyl-4,5-dihydroimidaz...)
Show SMILES CCCN1CCN(CC1)C1=NCCN1S(=O)(=O)c1ccc(cc1)C(C)C
Show InChI InChI=1S/C19H30N4O2S/c1-4-10-21-12-14-22(15-13-21)19-20-9-11-23(19)26(24,25)18-7-5-17(6-8-18)16(2)3/h5-8,16H,4,9-15H2,1-3H3
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n/an/a 0.150n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345342
PNG
(1-cyclobutyl-4-[1-[4-(3-pyridyl)phenyl]sulfonyl-4,...)
Show SMILES O=S(=O)(N1CCN=C1N1CCN(CC1)C1CCC1)c1ccc(cc1)-c1cccnc1
Show InChI InChI=1S/C22H27N5O2S/c28-30(29,21-8-6-18(7-9-21)19-3-2-10-23-17-19)27-12-11-24-22(27)26-15-13-25(14-16-26)20-4-1-5-20/h2-3,6-10,17,20H,1,4-5,11-16H2
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n/an/a 0.151n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345411
PNG
(6-[[2-(4-cyclobutylpiperazin-1-yl)-4,5-dihydroimid...)
Show SMILES O=S(=O)(N1CCN=C1N1CCN(CC1)C1CCC1)c1ccc2ncccc2c1
Show InChI InChI=1S/C20H25N5O2S/c26-28(27,18-6-7-19-16(15-18)3-2-8-21-19)25-10-9-22-20(25)24-13-11-23(12-14-24)17-4-1-5-17/h2-3,6-8,15,17H,1,4-5,9-14H2
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n/an/a 0.174n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345412
PNG
(5-[[2-(4-cyclobutylpiperazin-1-yl)-4,5-dihydroimid...)
Show SMILES Cn1cnc2cc(ccc12)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C19H26N6O2S/c1-22-14-21-17-13-16(5-6-18(17)22)28(26,27)25-8-7-20-19(25)24-11-9-23(10-12-24)15-3-2-4-15/h5-6,13-15H,2-4,7-12H2,1H3
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n/an/a 0.195n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345387
PNG
(1-(cyclopropylmethyl)-4-[1-(4-isopropylphenyl)sulf...)
Show SMILES CC(C)c1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(CC2CC2)CC1
Show InChI InChI=1S/C20H30N4O2S/c1-16(2)18-5-7-19(8-6-18)27(25,26)24-10-9-21-20(24)23-13-11-22(12-14-23)15-17-3-4-17/h5-8,16-17H,3-4,9-15H2,1-2H3
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n/an/a 0.198n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345403
PNG
(1-[1-(4-tert-butylphenyl)sulfonyl-4,5-dihydroimida...)
Show SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(CC2CC2)CC1
Show InChI InChI=1S/C21H32N4O2S/c1-21(2,3)18-6-8-19(9-7-18)28(26,27)25-11-10-22-20(25)24-14-12-23(13-15-24)16-17-4-5-17/h6-9,17H,4-5,10-16H2,1-3H3
PDB

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n/an/a 0.201n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345407
PNG
(N-[4-[[2-(4-cyclobutylpiperazin-1-yl)-4,5-dihydroi...)
Show SMILES CN(C(C)=O)c1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C20H29N5O3S/c1-16(26)22(2)17-6-8-19(9-7-17)29(27,28)25-11-10-21-20(25)24-14-12-23(13-15-24)18-4-3-5-18/h6-9,18H,3-5,10-15H2,1-2H3
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n/an/a 0.209n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345358
PNG
(1-[1-[4-(4-chlorophenyl)phe-nyl]sulfonyl-4,5-dihyd...)
Show SMILES Clc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C23H27ClN4O2S/c24-20-8-4-18(5-9-20)19-6-10-22(11-7-19)31(29,30)28-13-12-25-23(28)27-16-14-26(15-17-27)21-2-1-3-21/h4-11,21H,1-3,12-17H2
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US Patent
n/an/a 0.275n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345395
PNG
(1-cyclobutyl-4-[1-[3-(trifluoromethyl)phenyl]sulfo...)
Show SMILES FC(F)(F)c1cccc(c1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C18H23F3N4O2S/c19-18(20,21)14-3-1-6-16(13-14)28(26,27)25-8-7-22-17(25)24-11-9-23(10-12-24)15-4-2-5-15/h1,3,6,13,15H,2,4-5,7-12H2
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US Patent
n/an/a 0.278n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345397
PNG
(1-cyclobutyl-4-[1-(3,5-dichlorophenyl)sulfonyl-4,5...)
Show SMILES Clc1cc(Cl)cc(c1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C17H22Cl2N4O2S/c18-13-10-14(19)12-16(11-13)26(24,25)23-5-4-20-17(23)22-8-6-21(7-9-22)15-2-1-3-15/h10-12,15H,1-9H2
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US Patent
n/an/a 0.306n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345386
PNG
(1-cyclopropyl-4-[1-(4-isopropylphenyl)sulfonyl-4,5...)
Show SMILES CC(C)c1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CC1
Show InChI InChI=1S/C19H28N4O2S/c1-15(2)16-3-7-18(8-4-16)26(24,25)23-10-9-20-19(23)22-13-11-21(12-14-22)17-5-6-17/h3-4,7-8,15,17H,5-6,9-14H2,1-2H3
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US Patent
n/an/a 0.321n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345390
PNG
(6-[[2-(4-cyclobutylpiperazin-1-yl)-4,5-dihydroimid...)
Show SMILES Cn1c2ccc(cc2oc1=O)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C19H25N5O4S/c1-21-16-6-5-15(13-17(16)28-19(21)25)29(26,27)24-8-7-20-18(24)23-11-9-22(10-12-23)14-3-2-4-14/h5-6,13-14H,2-4,7-12H2,1H3
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US Patent
n/an/a 0.360n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345347
PNG
(1-cyclobutyl-4-[1-[4-[4-(trifluoromethyl)phe-nyl]p...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C24H27F3N4O2S/c25-24(26,27)20-8-4-18(5-9-20)19-6-10-22(11-7-19)34(32,33)31-13-12-28-23(31)30-16-14-29(15-17-30)21-2-1-3-21/h4-11,21H,1-3,12-17H2
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n/an/a 0.380n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345375
PNG
(1-(3-fluorocyclobutyl)-4-[1-(4-isopropylphenyl)sul...)
Show SMILES CC(C)c1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CC(F)C1
Show InChI InChI=1S/C20H29FN4O2S/c1-15(2)16-3-5-19(6-4-16)28(26,27)25-8-7-22-20(25)24-11-9-23(10-12-24)18-13-17(21)14-18/h3-6,15,17-18H,7-14H2,1-2H3
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US Patent
n/an/a 0.391n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345373
PNG
(1-[1-(4-isopropylphenyl)sulfonyl-4,5-dihydroimidaz...)
Show SMILES CC(C)c1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(CC2CC2C)CC1
Show InChI InChI=1S/C21H32N4O2S/c1-16(2)18-4-6-20(7-5-18)28(26,27)25-9-8-22-21(25)24-12-10-23(11-13-24)15-19-14-17(19)3/h4-7,16-17,19H,8-15H2,1-3H3
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n/an/a 0.492n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345399
PNG
(4-[[2-(4-cyclobutylpiperazin-1-yl)-4,5-dihydroimid...)
Show SMILES O=S(=O)(N1CCN=C1N1CCN(CC1)C1CCC1)c1cccc2nonc12
Show InChI InChI=1S/C17H22N6O3S/c24-27(25,15-6-2-5-14-16(15)20-26-19-14)23-8-7-18-17(23)22-11-9-21(10-12-22)13-3-1-4-13/h2,5-6,13H,1,3-4,7-12H2
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n/an/a 0.5n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345379
PNG
((S)-1-ethyl-4-[1-(4-isopropylphenyl)sulfonyl-4-met...)
Show SMILES CCN1CCN(CC1)C1=N[C@@H](C)CN1S(=O)(=O)c1ccc(cc1)C(C)C
Show InChI InChI=1S/C19H30N4O2S/c1-5-21-10-12-22(13-11-21)19-20-16(4)14-23(19)26(24,25)18-8-6-17(7-9-18)15(2)3/h6-9,15-16H,5,10-14H2,1-4H3/t16-/m0/s1
PDB

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n/an/a 0.519n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345430
PNG
(1-[1-(4-isopropylphenyl)sulfonyl-4,5-dihydroimidaz...)
Show SMILES CCC(C)CN1CCN(CC1)C1=NCCN1S(=O)(=O)c1ccc(cc1)C(C)C
Show InChI InChI=1S/C21H34N4O2S/c1-5-18(4)16-23-12-14-24(15-13-23)21-22-10-11-25(21)28(26,27)20-8-6-19(7-9-20)17(2)3/h6-9,17-18H,5,10-16H2,1-4H3
PDB

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US Patent
n/an/a 0.585n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345372
PNG
(1-cyclobutyl-4-[1-(4-isopropylphenyl)sulfonyl-4,5-...)
Show SMILES CC(C)c1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(C2CCC2)[C@@H](C)C1
Show InChI InChI=1S/C21H32N4O2S/c1-16(2)18-7-9-20(10-8-18)28(26,27)25-12-11-22-21(25)23-13-14-24(17(3)15-23)19-5-4-6-19/h7-10,16-17,19H,4-6,11-15H2,1-3H3/t17-/m0/s1
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n/an/a 0.689n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345374
PNG
(1-[1-(4-isopropylphenyl)sulfonyl-4,5-dihydroimidaz...)
Show SMILES CC(C)c1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CC(C)C1
Show InChI InChI=1S/C21H32N4O2S/c1-16(2)18-4-6-20(7-5-18)28(26,27)25-9-8-22-21(25)24-12-10-23(11-13-24)19-14-17(3)15-19/h4-7,16-17,19H,8-15H2,1-3H3
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n/an/a 0.860n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345445
PNG
(1-ethyl-4-[1-(2-naphthylsulfonyl)-4,5-dihydroimida...)
Show SMILES CCN1CCN(CC1)C1=NCCN1S(=O)(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C19H24N4O2S/c1-2-21-11-13-22(14-12-21)19-20-9-10-23(19)26(24,25)18-8-7-16-5-3-4-6-17(16)15-18/h3-8,15H,2,9-14H2,1H3
PDB

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n/an/a 0.998n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345433
PNG
(1-ethyl-4-[1-[4-(4-fluorophenyl)phenyl]sulfonyl-4,...)
Show SMILES CCN1CCN(CC1)C1=NCCN1S(=O)(=O)c1ccc(cc1)-c1ccc(F)cc1
Show InChI InChI=1S/C21H25FN4O2S/c1-2-24-13-15-25(16-14-24)21-23-11-12-26(21)29(27,28)20-9-5-18(6-10-20)17-3-7-19(22)8-4-17/h3-10H,2,11-16H2,1H3
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n/an/a 1.02n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345453
PNG
(1-[1-(2,6-dichlorophenyl)sulfonyl-4,5-dihydroimida...)
Show SMILES CCN1CCN(CC1)C1=NCCN1S(=O)(=O)c1c(Cl)cccc1Cl
Show InChI InChI=1S/C15H20Cl2N4O2S/c1-2-19-8-10-20(11-9-19)15-18-6-7-21(15)24(22,23)14-12(16)4-3-5-13(14)17/h3-5H,2,6-11H2,1H3
PDB

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n/an/a 1.02n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345436
PNG
(1-ethyl-4-[1-(4-methylsulfonylphenyl)sulfonyl-4,5-...)
Show SMILES CCN1CCN(CC1)C1=NCCN1S(=O)(=O)c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C16H24N4O4S2/c1-3-18-10-12-19(13-11-18)16-17-8-9-20(16)26(23,24)15-6-4-14(5-7-15)25(2,21)22/h4-7H,3,8-13H2,1-2H3
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n/an/a 1.12n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345383
PNG
(3-cyclobutyl-8-[1-(4-isopropylphenyl)sulfonyl-4,5-...)
Show SMILES CC(C)c1ccc(cc1)S(=O)(=O)N1CCN=C1N1C2CCC1CN(C2)C1CCC1
Show InChI InChI=1S/C22H32N4O2S/c1-16(2)17-6-10-21(11-7-17)29(27,28)25-13-12-23-22(25)26-19-8-9-20(26)15-24(14-19)18-4-3-5-18/h6-7,10-11,16,18-20H,3-5,8-9,12-15H2,1-2H3
PDB

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n/an/a 1.19n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345429
PNG
(US10202354, Example 94)
Show SMILES CC(C)c1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC(C)C1
Show InChI InChI=1S/C22H34N4O2S/c1-17(2)19-5-8-21(9-6-19)29(27,28)26-11-10-23-22(26)25-14-12-24(13-15-25)20-7-4-18(3)16-20/h5-6,8-9,17-18,20H,4,7,10-16H2,1-3H3
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n/an/a 1.42n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345437
PNG
(1-ethyl-4-[1-[4-(trifluoromethoxy)phenyl]sulfonyl-...)
Show SMILES CCN1CCN(CC1)C1=NCCN1S(=O)(=O)c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C16H21F3N4O3S/c1-2-21-9-11-22(12-10-21)15-20-7-8-23(15)27(24,25)14-5-3-13(4-6-14)26-16(17,18)19/h3-6H,2,7-12H2,1H3
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n/an/a 1.66n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345421
PNG
((3-chlorophenyl)-[2-(4-cyclobutylpiperazin-1-yl)-4...)
Show SMILES Clc1cccc(c1)C(=O)N1CCN=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C18H23ClN4O/c19-15-4-1-3-14(13-15)17(24)23-8-7-20-18(23)22-11-9-21(10-12-22)16-5-2-6-16/h1,3-4,13,16H,2,5-12H2
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n/an/a 2.04n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345423
PNG
((4-chlorophenyl)-[2-(4-cyclobutylpiperazin-1-yl)-4...)
Show SMILES Clc1ccc(cc1)C(=O)N1CCN=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C18H23ClN4O/c19-15-6-4-14(5-7-15)17(24)23-9-8-20-18(23)22-12-10-21(11-13-22)16-2-1-3-16/h4-7,16H,1-3,8-13H2
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n/an/a 2.21n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345422
PNG
((2-chlorophenyl)-[2-(4-cyclobutylpiperazin-1-yl)-4...)
Show SMILES Clc1ccccc1C(=O)N1CCN=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C18H23ClN4O/c19-16-7-2-1-6-15(16)17(24)23-9-8-20-18(23)22-12-10-21(11-13-22)14-4-3-5-14/h1-2,6-7,14H,3-5,8-13H2
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n/an/a 2.23n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345428
PNG
(1-[1-(4-isopropylphenyl)sulfonyl-4,5-dihydroimidaz...)
Show SMILES CC(C)c1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC(C)CC1
Show InChI InChI=1S/C23H36N4O2S/c1-18(2)20-6-10-22(11-7-20)30(28,29)27-13-12-24-23(27)26-16-14-25(15-17-26)21-8-4-19(3)5-9-21/h6-7,10-11,18-19,21H,4-5,8-9,12-17H2,1-3H3
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n/an/a 2.26n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345425
PNG
(US10202354, Example 90 | [2-(4-cyclobutylpiperazin...)
Show SMILES COc1cccc(c1)C(=O)N1CCN=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C19H26N4O2/c1-25-17-7-2-4-15(14-17)18(24)23-9-8-20-19(23)22-12-10-21(11-13-22)16-5-3-6-16/h2,4,7,14,16H,3,5-6,8-13H2,1H3
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n/an/a 2.29n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345419
PNG
(US10202354, Example 84 | [2-(4-cyclobutylpiperazin...)
Show SMILES Cc1ccc(cc1)C(=O)N1CCN=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C19H26N4O/c1-15-5-7-16(8-6-15)18(24)23-10-9-20-19(23)22-13-11-21(12-14-22)17-3-2-4-17/h5-8,17H,2-4,9-14H2,1H3
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n/an/a 2.70n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345449
PNG
(1-[1-(2-chlorophenyl)sulfonyl-4,5-dihydroimidazol-...)
Show SMILES CCN1CCN(CC1)C1=NCCN1S(=O)(=O)c1ccccc1Cl
Show InChI InChI=1S/C15H21ClN4O2S/c1-2-18-9-11-19(12-10-18)15-17-7-8-20(15)23(21,22)14-6-4-3-5-13(14)16/h3-6H,2,7-12H2,1H3
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n/an/a 2.81n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345435
PNG
(1-[1-(2,4-dichlorophenyl)sulfonyl-4,5-dihydroimida...)
Show SMILES CCN1CCN(CC1)C1=NCCN1S(=O)(=O)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C15H20Cl2N4O2S/c1-2-19-7-9-20(10-8-19)15-18-5-6-21(15)24(22,23)14-4-3-12(16)11-13(14)17/h3-4,11H,2,5-10H2,1H3
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n/an/a 2.83n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345385
PNG
(1-[1-(4-isopropylphenyl)sulfonyl-4,5-dihydroimidaz...)
Show SMILES COCCN1CCN(CC1)C1=NCCN1S(=O)(=O)c1ccc(cc1)C(C)C
Show InChI InChI=1S/C19H30N4O3S/c1-16(2)17-4-6-18(7-5-17)27(24,25)23-9-8-20-19(23)22-12-10-21(11-13-22)14-15-26-3/h4-7,16H,8-15H2,1-3H3
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n/an/a 2.91n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345418
PNG
(US10202354, Example 83 | [2-(4-cyclobutylpiperazin...)
Show SMILES Cc1ccccc1C(=O)N1CCN=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C19H26N4O/c1-15-5-2-3-8-17(15)18(24)23-10-9-20-19(23)22-13-11-21(12-14-22)16-6-4-7-16/h2-3,5,8,16H,4,6-7,9-14H2,1H3
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n/an/a 3.07n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345420
PNG
(US10202354, Example 85 | [2-(4-cyclobutylpiperazin...)
Show SMILES Cc1cccc(c1)C(=O)N1CCN=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C19H26N4O/c1-15-4-2-5-16(14-15)18(24)23-9-8-20-19(23)22-12-10-21(11-13-22)17-6-3-7-17/h2,4-5,14,17H,3,6-13H2,1H3
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n/an/a 3.12n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345431
PNG
(1-[1-(4-isopropylphenyl)sulfonyl-4,5-dihydroimidaz...)
Show SMILES CCCCC(C)N1CCN(CC1)C1=NCCN1S(=O)(=O)c1ccc(cc1)C(C)C
Show InChI InChI=1S/C22H36N4O2S/c1-5-6-7-19(4)24-14-16-25(17-15-24)22-23-12-13-26(22)29(27,28)21-10-8-20(9-11-21)18(2)3/h8-11,18-19H,5-7,12-17H2,1-4H3
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n/an/a 3.25n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345440
PNG
(1-[1-[4-(difluoromethoxy)phenyl]sulfonyl-4,5-dihyd...)
Show SMILES CCN1CCN(CC1)C1=NCCN1S(=O)(=O)c1ccc(OC(F)F)cc1
Show InChI InChI=1S/C16H22F2N4O3S/c1-2-20-9-11-21(12-10-20)16-19-7-8-22(16)26(23,24)14-5-3-13(4-6-14)25-15(17)18/h3-6,15H,2,7-12H2,1H3
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n/an/a 3.31n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345450
PNG
(1-ethyl-4-[1-(3-methoxyphenyl)sulfonyl-4,5-dihydro...)
Show SMILES CCN1CCN(CC1)C1=NCCN1S(=O)(=O)c1cccc(OC)c1
Show InChI InChI=1S/C16H24N4O3S/c1-3-18-9-11-19(12-10-18)16-17-7-8-20(16)24(21,22)15-6-4-5-14(13-15)23-2/h4-6,13H,3,7-12H2,1-2H3
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n/an/a 3.57n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345441
PNG
(1-[1-(2,5-dichlorophenyl)sulfonyl-4,5-dihydroimida...)
Show SMILES CCN1CCN(CC1)C1=NCCN1S(=O)(=O)c1cc(Cl)ccc1Cl
Show InChI InChI=1S/C15H20Cl2N4O2S/c1-2-19-7-9-20(10-8-19)15-18-5-6-21(15)24(22,23)14-11-12(16)3-4-13(14)17/h3-4,11H,2,5-10H2,1H3
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n/an/a 3.57n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345452
PNG
(1-ethyl-4-[1-(p-tolylsulfonyl)-4,5-dihydroimidazol...)
Show SMILES CCN1CCN(CC1)C1=NCCN1S(=O)(=O)c1ccc(C)cc1
Show InChI InChI=1S/C16H24N4O2S/c1-3-18-10-12-19(13-11-18)16-17-8-9-20(16)23(21,22)15-6-4-14(2)5-7-15/h4-7H,3,8-13H2,1-2H3
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n/an/a 3.76n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345442
PNG
(1-ethyl-4-[1-[4-(trifluoromethyl)phenyl]sulfonyl-4...)
Show SMILES CCN1CCN(CC1)C1=NCCN1S(=O)(=O)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C16H21F3N4O2S/c1-2-21-9-11-22(12-10-21)15-20-7-8-23(15)26(24,25)14-5-3-13(4-6-14)16(17,18)19/h3-6H,2,7-12H2,1H3
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n/an/a 3.92n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345384
PNG
(4-[1-[1-(4-isopropylphenyl)sulfonyl-4,5-dihydroimi...)
Show SMILES CC(C)c1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCC(CC1)N1CCOCC1
Show InChI InChI=1S/C21H32N4O3S/c1-17(2)18-3-5-20(6-4-18)29(26,27)25-12-9-22-21(25)24-10-7-19(8-11-24)23-13-15-28-16-14-23/h3-6,17,19H,7-16H2,1-2H3
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n/an/a 4.22n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345424
PNG
(US10202354, Example 89 | [2-(4-cyclobutylpiperazin...)
Show SMILES COc1ccc(cc1)C(=O)N1CCN=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C19H26N4O2/c1-25-17-7-5-15(6-8-17)18(24)23-10-9-20-19(23)22-13-11-21(12-14-22)16-3-2-4-16/h5-8,16H,2-4,9-14H2,1H3
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n/an/a 4.38n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345451
PNG
(1-ethyl-4-[1-(4-methoxyphenyl)sulfonyl-4,5-dihydro...)
Show SMILES CCN1CCN(CC1)C1=NCCN1S(=O)(=O)c1ccc(OC)cc1
Show InChI InChI=1S/C16H24N4O3S/c1-3-18-10-12-19(13-11-18)16-17-8-9-20(16)24(21,22)15-6-4-14(23-2)5-7-15/h4-7H,3,8-13H2,1-2H3
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n/an/a 5.45n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345406
PNG
(5-[[2-(4-cyclobutylpiperazin-1-yl)-4,5-dihydroimid...)
Show SMILES CN1C(=O)Cc2cc(ccc12)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C20H27N5O3S/c1-22-18-6-5-17(13-15(18)14-19(22)26)29(27,28)25-8-7-21-20(25)24-11-9-23(10-12-24)16-3-2-4-16/h5-6,13,16H,2-4,7-12,14H2,1H3
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n/an/a 5.70n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345434
PNG
(1-ethyl-4-[1-[3-(trifluoromethoxy)phenyl]sulfonyl-...)
Show SMILES CCN1CCN(CC1)C1=NCCN1S(=O)(=O)c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C16H21F3N4O3S/c1-2-21-8-10-22(11-9-21)15-20-6-7-23(15)27(24,25)14-5-3-4-13(12-14)26-16(17,18)19/h3-5,12H,2,6-11H2,1H3
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n/an/a 6.22n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345444
PNG
(1-[1-(2,4-difluorophenyl)sulfonyl-4,5-dihydroimida...)
Show SMILES CCN1CCN(CC1)C1=NCCN1S(=O)(=O)c1ccc(F)cc1F
Show InChI InChI=1S/C15H20F2N4O2S/c1-2-19-7-9-20(10-8-19)15-18-5-6-21(15)24(22,23)14-4-3-12(16)11-13(14)17/h3-4,11H,2,5-10H2,1H3
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n/an/a 6.33n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345438
PNG
(1-ethyl-4-[1-[3-(trifluoromethyl)phenyl]sulfonyl-4...)
Show SMILES CCN1CCN(CC1)C1=NCCN1S(=O)(=O)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C16H21F3N4O2S/c1-2-21-8-10-22(11-9-21)15-20-6-7-23(15)26(24,25)14-5-3-4-13(12-14)16(17,18)19/h3-5,12H,2,6-11H2,1H3
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n/an/a 6.99n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345417
PNG
(US10202354, Example 82 | [2-(4-cyclobutylpiperazin...)
Show SMILES O=C(N1CCN=C1N1CCN(CC1)C1CCC1)c1ccccc1
Show InChI InChI=1S/C18H24N4O/c23-17(15-5-2-1-3-6-15)22-10-9-19-18(22)21-13-11-20(12-14-21)16-7-4-8-16/h1-3,5-6,16H,4,7-14H2
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n/an/a 7n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345439
PNG
(1-[1-[3-(difluoromethoxy)phenyl]sulfonyl-4,5-dihyd...)
Show SMILES CCN1CCN(CC1)C1=NCCN1S(=O)(=O)c1cccc(OC(F)F)c1
Show InChI InChI=1S/C16H22F2N4O3S/c1-2-20-8-10-21(11-9-20)16-19-6-7-22(16)26(23,24)14-5-3-4-13(12-14)25-15(17)18/h3-5,12,15H,2,6-11H2,1H3
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n/an/a 7.76n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345368
PNG
(1-ethyl-4-[1-[2-(trifluoromethoxy)phenyl]sulfonyl-...)
Show SMILES CCN1CCN(CC1)C1=NCCN1S(=O)(=O)c1ccccc1OC(F)(F)F
Show InChI InChI=1S/C16H21F3N4O3S/c1-2-21-9-11-22(12-10-21)15-20-7-8-23(15)27(24,25)14-6-4-3-5-13(14)26-16(17,18)19/h3-6H,2,7-12H2,1H3
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US Patent
n/an/a 8.51n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345378
PNG
((R)-1-ethyl-4-[1-(4-isopropylphenyl)sulfonyl-4-met...)
Show SMILES CCN1CCN(CC1)C1=N[C@H](C)CN1S(=O)(=O)c1ccc(cc1)C(C)C
Show InChI InChI=1S/C19H30N4O2S/c1-5-21-10-12-22(13-11-21)19-20-16(4)14-23(19)26(24,25)18-8-6-17(7-9-18)15(2)3/h6-9,15-16H,5,10-14H2,1-4H3/t16-/m1/s1
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n/an/a 8.76n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345448
PNG
(1-[1-(3-chlorophenyl)sulfonyl-4,5-dihydroimidazol-...)
Show SMILES CCN1CCN(CC1)C1=NCCN1S(=O)(=O)c1cccc(Cl)c1
Show InChI InChI=1S/C15H21ClN4O2S/c1-2-18-8-10-19(11-9-18)15-17-6-7-20(15)23(21,22)14-5-3-4-13(16)12-14/h3-5,12H,2,6-11H2,1H3
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n/an/a 9.06n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345447
PNG
(2-[[2-(4-ethylpiperazin-1-yl)-4,5-dihydroimidazol-...)
Show SMILES CCN1CCN(CC1)C1=NCCN1S(=O)(=O)c1ccccc1C#N
Show InChI InChI=1S/C16H21N5O2S/c1-2-19-9-11-20(12-10-19)16-18-7-8-21(16)24(22,23)15-6-4-3-5-14(15)13-17/h3-6H,2,7-12H2,1H3
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n/an/a 9.81n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345432
PNG
(1-(3,3-dimethylcyclopentyl)-4-[1-(4-isopropylpheny...)
Show SMILES CC(C)c1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC(C)(C)C1
Show InChI InChI=1S/C23H36N4O2S/c1-18(2)19-5-7-21(8-6-19)30(28,29)27-12-11-24-22(27)26-15-13-25(14-16-26)20-9-10-23(3,4)17-20/h5-8,18,20H,9-17H2,1-4H3
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n/an/a 10.5n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345454
PNG
(1-ethyl-4-[1-(1-ethyl-5-methyl-pyrazol-4-yl)sulfon...)
Show SMILES CCN1CCN(CC1)C1=NCCN1S(=O)(=O)c1cnn(CC)c1C
Show InChI InChI=1S/C15H26N6O2S/c1-4-18-8-10-19(11-9-18)15-16-6-7-21(15)24(22,23)14-12-17-20(5-2)13(14)3/h12H,4-11H2,1-3H3
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n/an/a 11.4n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345404
PNG
(1-[1-(3,4-dichlorophenyl)sulfonyl-4,5-dihydroimida...)
Show SMILES CCN1CCN(CC1)C1=NCCN1S(=O)(=O)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C15H20Cl2N4O2S/c1-2-19-7-9-20(10-8-19)15-18-5-6-21(15)24(22,23)12-3-4-13(16)14(17)11-12/h3-4,11H,2,5-10H2,1H3
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n/an/a 11.5n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345426
PNG
(US10202354, Example 91 | [2-(4-cyclobutylpiperazin...)
Show SMILES Oc1ccccc1C(=O)N1CCN=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C18H24N4O2/c23-16-7-2-1-6-15(16)17(24)22-9-8-19-18(22)21-12-10-20(11-13-21)14-4-3-5-14/h1-2,6-7,14,23H,3-5,8-13H2
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n/an/a 11.5n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345443
PNG
(1-[1-(2,6-difluorophenyl)sulfonyl-4,5-dihydroimida...)
Show SMILES CCN1CCN(CC1)C1=NCCN1S(=O)(=O)c1c(F)cccc1F
Show InChI InChI=1S/C15H20F2N4O2S/c1-2-19-8-10-20(11-9-19)15-18-6-7-21(15)24(22,23)14-12(16)4-3-5-13(14)17/h3-5H,2,6-11H2,1H3
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n/an/a 12.8n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345455
PNG
(4-[[2-(4-ethylpiperazin-1-yl)-4,5-dihydroimidazol-...)
Show SMILES CCN1CCN(CC1)C1=NCCN1S(=O)(=O)c1cccc2nonc12
Show InChI InChI=1S/C15H20N6O3S/c1-2-19-8-10-20(11-9-19)15-16-6-7-21(15)25(22,23)13-5-3-4-12-14(13)18-24-17-12/h3-5H,2,6-11H2,1H3
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n/an/a 13.3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345446
PNG
(1-ethyl-4-[1-(2-methoxyphenyl)sulfonyl-4,5-dihydro...)
Show SMILES CCN1CCN(CC1)C1=NCCN1S(=O)(=O)c1ccccc1OC
Show InChI InChI=1S/C16H24N4O3S/c1-3-18-10-12-19(13-11-18)16-17-8-9-20(16)24(21,22)15-7-5-4-6-14(15)23-2/h4-7H,3,8-13H2,1-2H3
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n/an/a 13.3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%